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1. Comparison of Ampullary and Pancreatic Adenocarcinomas: Smaller Invasion, Common Adenomatous Components, Resectability, and Histology are Factors for Improved Survival for Patients with Ampullary Adenocarcinoma

Author

Memis, Bahar, Saka, Burcu, Pehlivanoglu, Burcin, Kim, Grace, Balci, Serdar, Tajiri, Takuma, Ohike, Nobuyuki, Bagci, Pelin, Akar, Kadriye Ebru, Muraki, Takashi, Jang, Kee-Taek, Maithel, Shishir K., Sarmiento, Juan, Kooby, David A., Esmer, Rohat, Tarcan, Zeynep Cagla, Goodman, Michael, Xue, Yue, Krasinskas, Alyssa, Reid, Michelle, Basturk, Olca, and Adsay, Volkan

Published
2024
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2. Subgrading of G2 Pancreatic Neuroendocrine Tumors as 2A (Ki67 3% to < 10%) Versus 2B (10% to ≤ 20%) Identifies Behaviorally Distinct Subsets in Keeping with the Evolving Management Protocols

Author

Eren, Ozgur Can, Bagci, Pelin, Balci, Serdar, Ohike, Nobuyuki, Saka, Burcu, Sokmensuer, Cenk, Leblebici, Can Berk, Xue, Yue, Reid, Michelle D., Krasinskas, Alyssa M., Kooby, David, Maithel, Shishir K., Sarmiento, Juan, Cheng, Jeanette D., Taskin, Orhun Cig, Kapran, Yersu, Tarcan, Zeynep Cagla, Luchini, Claudio, Scarpa, Aldo, Basturk, Olca, and Adsay, N. Volkan

Published
2024
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3. ASO Visual Abstract: Comparison of Ampullary and Pancreatic Adenocarcinomas—Smaller Invasion, Common Adenomatous Components, Resectability, and Histology are Factors for Improved Survival for Patients with Ampullary Adenocarcinoma

Author

Memis, Bahar, Saka, Burcu, Pehlivanoglu, Burcin, Kim, Grace, Balci, Serdar, Tajiri, Takuma, Ohike, Nobuyuki, Bagci, Pelin, Akar, Kadriye Ebru, Muraki, Takashi, Jang, Kee-Taek, Maithel, Shishir K., Sarmiento, Juan, Kooby, David A., Esmer, Rohat, Tarcan, Zeynep Cagla, Goodman, Michael, Xue, Yue, Krasinskas, Alyssa, Reid, Michelle, Basturk, Olca, and Adsay, Volkan

Published
2024
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4. ASO Author Reflections: Prognostic Value of Subgrading G2 Pancreatic Neuroendocrine Tumors as 2A versus 2B

Author

Eren, Ozgur Can, Bagci, Pelin, Balci, Serdar, Ohike, Nobuyuki, Saka, Burcu, Sokmensuer, Cenk, Leblebici, Can Berk, Xue, Yue, Reid, Michelle D., Krasinskas, Alyssa M., Kooby, David, Maithel, Shishir K., Sarmiento, Juan, Cheng, Jeanette D., Taskin, Orhun Cig, Kapran, Yersu, Tarcan, Zeynep, Luchini, Claudio, Scarpa, Aldo, Basturk, Olca, and Adsay, N. Volkan

Published
2024
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5. Pathologic Examination of Pancreatic Specimens Resected for Treated Pancreatic Ductal Adenocarcinoma

Author

Wang, Huamin, Chetty, Runjan, Hosseini, Mojgan, Allende, Daniela S, Esposito, Irene, Matsuda, Yoko, Deshpande, Vikram, Shi, Jiaqi, Dhall, Deepti, Jang, Kee-Taek, Kim, Grace E, Luchini, Claudio, Graham, Rondell P, Reid, Michelle D, Basturk, Olca, Hruban, Ralph H, Krasinskas, Alyssa, Klimstra, David S, Adsay, Volkan, and Society, for the Pancreatobiliary Pathology

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Pancreatic Cancer, Digestive Diseases, Rare Diseases, Artificial Intelligence, Carcinoma, Pancreatic Ductal, Humans, Neoadjuvant Therapy, Pancreatectomy, Pancreatic Ducts, Pancreatic Neoplasms, pancreatic ductal adenocarcinoma, neoadjuvant therapy, gross examination, mapping sections, tumor size, tumor response grade, survival, lymph node metastasis, Pancreatobiliary Pathology Society, Clinical Sciences, Pathology, Clinical sciences
Abstract

Currently, there are no internationally accepted consensus guidelines for pathologic evaluation of posttherapy pancreatectomy specimens. The Neoadjuvant Therapy Working Group of Pancreatobiliary Pathology Society was formed in 2018 to review grossing protocols, literature, and major issues and to develop recommendations for pathologic evaluation of posttherapy pancreatectomy specimens. The working group generated the following recommendations: (1) Systematic and standardized grossing and sampling protocols should be adopted for pancreatectomy specimens for treated pancreatic ductal adenocarcinoma (PDAC). (2) Consecutive mapping sections along the largest gross tumor dimension are recommended to validate tumor size by histology as required by the College of American Pathologists (CAP) cancer protocol. (3) Tumor size of treated PDACs should be measured microscopically as the largest dimension of tumor outer limits that is bound by viable tumor cells, including intervening stroma. (4) The MD Anderson grading system for tumor response has a better correlation with prognosis and better interobserver concordance among pathologists than does the CAP system. (5) A case should not be classified as a complete response unless the entire pancreas, peripancreatic tissues, ampulla of Vater, common bile duct, and duodenum adjacent to the pancreas are submitted for microscopic examination. (6) Future studies on tumor response of lymph node metastases, molecular and/or immunohistochemical markers, as well as application of artificial intelligence in grading tumor response of treated PDAC are needed. In summary, systematic, standardized pathologic evaluation, accurate tumor size measurement, and reproducible tumor response grading to neoadjuvant therapy are needed for optimal patient care. The criteria and discussions provided here may provide guidance towards these goals.

Published
2022

9. Amsterdam International Consensus Meeting: tumor response scoring in the pathology assessment of resected pancreatic cancer after neoadjuvant therapy

Author

Janssen, Boris V., Tutucu, Faik, van Roessel, Stijn, Adsay, Volkan, Basturk, Olca, Campbell, Fiona, Doglioni, Claudio, Esposito, Irene, Feakins, Roger, Fukushima, Noriyoshi, Gill, Anthony J., Hruban, Ralph H., Kaplan, Jeffrey, Koerkamp, Bas Groot, Hong, Seung-Mo, Krasinskas, Alyssa, Luchini, Claudio, Offerhaus, Johan, Sarasqueta, Arantza Fariña, Shi, Chanjuan, Singhi, Aatur, Stoop, Thomas F., Soer, Eline C., Thompson, Elizabeth, van Tienhoven, Geertjan, Velthuysen, Marie-Louise F., Wilmink, Johanna W., Besselink, Marc G., Brosens, Lodewijk A.A., Wang, Huamin, Verbeke, Caroline S., and Verheij, Joanne

Published
2021
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13. Intrapancreatic distal common bile duct carcinoma: Analysis, staging considerations, and comparison with pancreatic ductal and ampullary adenocarcinomas

Author

Gonzalez, Raul S, Bagci, Pelin, Basturk, Olca, Reid, Michelle D, Balci, Serdar, Knight, Jessica H, Kong, So Yeon, Memis, Bahar, Jang, Kee-Taek, Ohike, Nobuyuki, Tajiri, Takuma, Bandyopadhyay, Sudeshna, Krasinskas, Alyssa M, Kim, Grace E, Cheng, Jeanette D, and Adsay, N Volkan

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Pancreatic Cancer, Digestive Diseases, Rare Diseases, Cancer, Adenocarcinoma, Adult, Aged, Aged, 80 and over, Ampulla of Vater, Carcinoma, Pancreatic Ductal, Common Bile Duct Neoplasms, Female, Humans, Male, Middle Aged, Neoplasm Staging, Pancreatic Neoplasms, Medical and Health Sciences, Pathology, Clinical sciences
Abstract

Distal common bile duct carcinoma is a poorly characterized entity for reasons such as variable terminology and difficulty in determining site of origin of intrapancreatic lesions. We compared clinicopathologic features of pancreatobiliary-type adenocarcinomas within the pancreas, but arising from the distal common bile duct, with those of pancreatic and ampullary origin. Upon careful review of 1017 pancreatoduodenectomy specimens with primary adenocarcinoma, 52 (5%) qualified as intrapancreatic distal common bile duct carcinoma. Five associated with an intraductal papillary neoplasm were excluded; the remaining 47 were compared to 109 pancreatic ductal adenocarcinomas and 133 ampullary carcinomas. Distal common bile duct carcinoma patients had a younger median age (58 years) than pancreatic ductal adenocarcinoma patients (65 years) and ampullary carcinoma patients (68 years). Distal common bile duct carcinoma was intermediate between pancreatic ductal adenocarcinoma and ampullary carcinoma with regard to tumor size and rates of node metastases and margin positivity. Median survival was better than for pancreatic ductal adenocarcinoma (P=0.0010) but worse than for ampullary carcinoma (P=0.0006). Distal common bile duct carcinoma often formed an even band around the common bile duct and commonly showed intraglandular neutrophil-rich debris and a small tubular pattern. Poor prognostic indicators included node metastasis (P=0.0010), lymphovascular invasion (P=0.0299), and margin positivity (P=0.0069). Categorizing the tumors based on size also had prognostic relevance (P=0.0096), unlike categorization based on anatomic structures invaded. Primary distal common bile duct carcinoma is seen in younger patients than pancreatic ductal adenocarcinoma or ampullary carcinoma. Its prognosis is significantly better than pancreatic ductal adenocarcinoma and worse than ampullary carcinoma, at least partly because of differences in clinical presentation. Use of size-based criteria for staging appears to improve its prognostic relevance. Invasive pancreatobiliary-type distal common bile duct carcinomas are uncommon in the West and have substantial clinicopathologic differences from carcinomas arising from the pancreas and ampulla.

Published
2016

14. Pathologic Examination of Pancreatic Specimens Resected for Treated Pancreatic Ductal Adenocarcinoma: Recommendations From the Pancreatobiliary Pathology Society

Author

Wang, Huamin, Chetty, Runjan, Hosseini, Mojgan, Allende, Daniela S., Esposito, Irene, Matsuda, Yoko, Deshpande, Vikram, Shi, Jiaqi, Dhall, Deepti, Jang, Kee-Taek, Kim, Grace E., Luchini, Claudio, Graham, Rondell P., Reid, Michelle D., Basturk, Olca, Hruban, Ralph H., Krasinskas, Alyssa, Klimstra, David S., and Adsay, Volkan

Published
2021
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15. Suppressive myeloid cells are expanded by biliary tract cancer-derived cytokines in vitro and associate with aggressive disease

Author

Ware, Michael B., Zaidi, Mohammad Y., Yang, Jennifer, Turgeon, Michael K., Krasinskas, Alyssa, Mace, Thomas A., Keenan, Kaitlin, Farren, Matthew R., Ruggieri, Amanda N., Li, Yiman, Zhang, Chao, Chen, Zhengjia, Young, Gregory S., Elnaggar, Omar, Che, Zheng, Maithel, Shishir K., Bekaii-Saab, Tanios, El-Rayes, Bassel, and Lesinski, Gregory B.

Published
2020
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16. Substaging Nodal Status in Ampullary Carcinomas has Significant Prognostic Value: Proposed Revised Staging Based on an Analysis of 313 Well-Characterized Cases

Author

Balci, Serdar, Basturk, Olca, Saka, Burcu, Bagci, Pelin, Postlewait, Lauren M, Tajiri, Takuma, Jang, Kee-Taek, Ohike, Nobuyuki, Kim, Grace E, Krasinskas, Alyssa, Choi, Hyejeong, Sarmiento, Juan M, Kooby, David A, El-Rayes, Bassel F, Knight, Jessica H, Goodman, Michael, Akkas, Gizem, Reid, Michelle D, Maithel, Shishir K, and Adsay, Volkan

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Adenocarcinoma, Adult, Aged, Aged, 80 and over, Ampulla of Vater, Common Bile Duct Neoplasms, Female, Follow-Up Studies, Humans, Lymph Nodes, Male, Middle Aged, Neoplasm Staging, Pancreatic Neoplasms, Prognosis, Survival Rate, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundCurrent nodal staging (N-staging) of ampullary carcinoma in the TNM staging system distinguishes between node-negative (N0) and node-positive (N1) disease but does not consider the metastatic lymph node (LN) number.MethodsOverall, 313 patients who underwent pancreatoduodenectomy for ampullary adenocarcinoma were categorized as N0, N1 (1-2 metastatic LNs), or N2 (≥3 metastatic LNs), as proposed by Kang et al. Clinicopathological features and overall survival (OS) of the three groups were compared.ResultsThe median number of LNs examined was 11, and LN metastasis was present in 142 cases (45 %). When LN-positive cases were re-classified according to the proposed staging system, 82 were N1 (26 %) and 60 were N2 (19 %). There was a significant correlation between proposed N-stage and lymphovascular invasion, perineural invasion, increased tumor size (each p < 0.001), and surgical margin positivity (p = 0.001). The median OS in LN-negative cases was significantly longer than that in LN-positive cases (107.5 vs. 32 months; p < 0.001). Patients with N1 and N2 disease had median survivals of 40 and 24.5 months, respectively (p < 0.0001). In addition, 1-, 3-, and 5-year survivals were 88, 76, 62 %, respectively, for N0; 90, 55, 31.5 %, respectively, for N1; and 68, 34, 30 %, respectively for N2 (p < 0.001). Even with multivariate modeling, the association between higher proposed N stage and shorter survival persisted (hazard ratio 1.6 for N1 and 1.9 for N2; p = 0.018).ConclusionsClassification of nodal status in ampullary carcinomas based on the number of metastatic LNs has a significant prognostic value. A revised N-staging classification system should be incorporated into the TNM staging of ampullary cancers.

Published
2015

17. Galectin-9 as a regulator of immune interactions in the tumor microenvironment and novel therapeutic target in biliary tract cancer.

Author

Warren, Emilie AK, primary, Hammons, Jacklyn, additional, Keilson, Jessica M., additional, Wyatt, Megan, additional, Medin, Caroline, additional, Henry, Curtis, additional, Kulkarni, Sarah, additional, Liu, Yuan, additional, Robinson, Brian, additional, Krasinskas, Alyssa, additional, Maithel, Shishir K., additional, Paulos, Chrystal M, additional, and Lesinski, Gregory B., additional

Published
2024
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18. Development of a Plasma Screening Panel for Pediatric Nonalcoholic Fatty Liver Disease Using Metabolomics

Author

Richard D. Khusial, Catherine E. Cioffi, Shelley A. Caltharp, Alyssa M. Krasinskas, Adina Alazraki, Jack Knight‐Scott, Rebecca Cleeton, Eduardo Castillo‐Leon, Dean P. Jones, Bridget Pierpont, Sonia Caprio, Nicola Santoro, Ayman Akil, and Miriam B. Vos

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children, but diagnosis is challenging due to limited availability of noninvasive biomarkers. Machine learning applied to high‐resolution metabolomics and clinical phenotype data offers a novel framework for developing a NAFLD screening panel in youth. Here, untargeted metabolomics by liquid chromatography–mass spectrometry was performed on plasma samples from a combined cross‐sectional sample of children and adolescents ages 2‐25 years old with NAFLD (n = 222) and without NAFLD (n = 337), confirmed by liver biopsy or magnetic resonance imaging. Anthropometrics, blood lipids, liver enzymes, and glucose and insulin metabolism were also assessed. A machine learning approach was applied to the metabolomics and clinical phenotype data sets, which were split into training and test sets, and included dimension reduction, feature selection, and classification model development. The selected metabolite features were the amino acids serine, leucine/isoleucine, and tryptophan; three putatively annotated compounds (dihydrothymine and two phospholipids); and two unknowns. The selected clinical phenotype variables were waist circumference, whole‐body insulin sensitivity index (WBISI) based on the oral glucose tolerance test, and blood triglycerides. The highest performing classification model was random forest, which had an area under the receiver operating characteristic curve (AUROC) of 0.94, sensitivity of 73%, and specificity of 97% for detecting NAFLD cases. A second classification model was developed using the homeostasis model assessment of insulin resistance substituted for the WBISI. Similarly, the highest performing classification model was random forest, which had an AUROC of 0.92, sensitivity of 73%, and specificity of 94%. Conclusion: The identified screening panel consisting of both metabolomics and clinical features has promising potential for screening for NAFLD in youth. Further development of this panel and independent validation testing in other cohorts are warranted.

Published
2019
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20. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

Author

Whitcomb, David C, LaRusch, Jessica, Krasinskas, Alyssa M, Klei, Lambertus, Smith, Jill P, Brand, Randall E, Neoptolemos, John P, Lerch, Markus M, Tector, Matt, Sandhu, Bimaljit S, Guda, Nalini M, Orlichenko, Lidiya, Alkaade, Samer, Amann, Stephen T, Anderson, Michelle A, Baillie, John, Banks, Peter A, Conwell, Darwin, Coté, Gregory A, Cotton, Peter B, DiSario, James, Farrer, Lindsay A, Forsmark, Chris E, Johnstone, Marianne, Gardner, Timothy B, Gelrud, Andres, Greenhalf, William, Haines, Jonathan L, Hartman, Douglas J, Hawes, Robert A, Lawrence, Christopher, Lewis, Michele, Mayerle, Julia, Mayeux, Richard, Melhem, Nadine M, Money, Mary E, Muniraj, Thiruvengadam, Papachristou, Georgios I, Pericak-Vance, Margaret A, Romagnuolo, Joseph, Schellenberg, Gerard D, Sherman, Stuart, Simon, Peter, Singh, Vijay P, Slivka, Adam, Stolz, Donna, Sutton, Robert, Weiss, Frank Ulrich, Wilcox, C Mel, Zarnescu, Narcis Octavian, Wisniewski, Stephen R, O'Connell, Michael R, Kienholz, Michelle L, Roeder, Kathryn, Barmada, M Michael, Yadav, Dhiraj, and Devlin, Bernie

Subjects
Biological Sciences, Genetics, Digestive Diseases, Prevention, Alcoholism, Alcohol Use and Health, Human Genome, Clinical Research, Substance Misuse, 2.1 Biological and endogenous factors, Cardiovascular, Stroke, Oral and gastrointestinal, Good Health and Well Being, Claudins, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Homozygote, Humans, Male, Mutation, Pancreatitis, Alcoholic, Sex Factors, Trypsin, Trypsinogen, Alzheimer's Disease Genetics Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 (P < 1 × 10(-12)) and X-linked CLDN2 (P < 1 × 10(-21)) through a two-stage genome-wide study (stage 1: 676 cases and 4,507 controls; stage 2: 910 cases and 4,170 controls). The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous (or hemizygous in males) CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men (male hemizygote frequency is 0.26, whereas female homozygote frequency is 0.07).

Published
2012

24. Non-ampullary–duodenal carcinomas: clinicopathologic analysis of 47 cases and comparison with ampullary and pancreatic adenocarcinomas

Author

Xue, Yue, Vanoli, Alessandro, Balci, Serdar, Reid, Michelle M, Saka, Burcu, Bagci, Pelin, Memis, Bahar, Choi, Hyejeong, Ohike, Nobuyike, Tajiri, Takuma, Muraki, Takashi, Quigley, Brian, El-Rayes, Bassel F, Shaib, Walid, Kooby, David, Sarmiento, Juan, Maithel, Shishir K, Knight, Jessica H, Goodman, Michael, Krasinskas, Alyssa M, and Adsay, Volkan

Published
2017
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26. Ampullary carcinoma is often of mixed or hybrid histologic type: an analysis of reproducibility and clinical relevance of classification as pancreatobiliary versus intestinal in 232 cases

Author

Reid, Michelle D, Balci, Serdar, Ohike, Nobuyuki, Xue, Yue, Kim, Grace E, Tajiri, Takuma, Memis, Bahar, Coban, Ipek, Dolgun, Anil, Krasinskas, Alyssa M, Basturk, Olca, Kooby, David A, Sarmiento, Juan M, Maithel, Shishir K, El-Rayes, Bassel F, and Adsay, Volkan

Published
2016
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27. Adenocarcinoma ex-goblet cell carcinoid (appendiceal-type crypt cell adenocarcinoma) is a morphologically distinct entity with highly aggressive behavior and frequent association with peritoneal/intra-abdominal dissemination: an analysis of 77 cases

Author

Reid, Michelle D, Basturk, Olca, Shaib, Walid L, Xue, Yue, Balci, Serdar, Choi, Hye-Jeong, Akkas, Gizem, Memis, Bahar, Robinson, Brian S, El-Rayes, Bassel F, Staley, Charles A, Staley, Christopher A, Winer, Joshua H, Russell, Maria C, Knight, Jessica H, Goodman, Michael, Krasinskas, Alyssa M, and Adsay, Volkan

Published
2016
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30. Histologic Variants of Kaposi Sarcoma in the Gastrointestinal Tract

Author

Wei Zheng, Rebecca C. Obeng, Rondell P. Graham, Shu Lui, Jerome Cheng, Borislav A. Alexiev, Brian Quigley, Alyssa Krasinskas, Guang-Yu Yang, David Escobar, Xiuli Liu, Pooja Navale, Michelle D. Reid, Maria Westerhoff, and Yue Xue

Subjects
Skin Neoplasms, Gastrointestinal Stromal Tumors, Herpesvirus 8, Human, Humans, Surgery, Anatomy, Sarcoma, Kaposi, Pathology and Forensic Medicine
Abstract

Kaposi sarcoma (KS) can pose diagnostic challenges in biopsy specimens. Multiple histologic variants of cutaneous KS have been described; however, the histomorphologic spectrum of gastrointestinal (GI) KS has not been systematically studied. This large series comprehensively evaluated 46 cases of KS involving the GI tract and identified 7 histomorphologic variants, some that have not been previously described. Five of them are inconspicuous but have unique morphologic patterns, including lymphangioma/lymphangiectatic-like (n=17), mucosal hemorrhage/telangiectatic-like (n=17), mucosal inflammation-like (n=15), granulation tissue-like (n=13), and mucosal prolapse-like (n=4) variants. These variants can be easily misdiagnosed or misinterpreted on routine examination if KS is not considered, and if the immunohistochemical stain for human herpesvirus-8 is not performed. The other 2 morphologic variants present as spindle cell proliferations and are the GI stromal tumor-like (n=8) and inflammatory myofibroblastic tumor-like (n=2). These variants raise a broad differential diagnosis of spindle cell tumors of the GI tract and could pose diagnostic challenges. In summary, GI KS lesions exhibit variable, often unconventional histomorphologic patterns. KS should be included in the differential diagnosis even if features of conventional KS are not seen, particularly in limited biopsies in immunocompromised patients, such as those with human immunodeficiency virus infection. Although the clinical significance of these morphologic variants is yet to be determined, they are nonetheless important from a diagnostic standpoint. Misdiagnosis and delay in appropriate management can be avoided by recognizing the morphologic diversity of GI KS and appropriately utilizing the human herpesvirus-8 immunohistochemical stain.

Published
2022
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33. Phase IB Study of Induction Chemotherapy With XELOX, Followed by Radiation Therapy, Carboplatin, and Everolimus in Patients With Locally Advanced Esophageal Cancer

Author

Saba, Nabil F., Force, Seth, Staley, Charley, Fernandez, Felix, Willingham, Field, Pickens, Allan, Cardona, Kenneth, Chen, Zhengjia, Goff, Laura, Cardin, Dana, Lambright, Eric, Nesbitt, Jon, Krasinskas, Alyssa, Higgins, Kristin, Harvey, R. Donald, Owonikoko, Taofeek, Ramalingam, Suresh S., Shin, Dong M., Beitler, Jonathan J., El-Rayes, Bassel F., Salaria, Safia, El-Rifai, Wael, Landry, Jerome, and Chakravarthy, A.B.

Published
2019
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38. Infiltrative Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis Treated With a Single High-Dose Y90 Radioembolization and Subsequent Liver Transplantation Without a Recurrence

Author

Meaghan S. Dendy, MD, Juan C. Camacho, MD, Johannes M. Ludwig, MD, Alyssa M. Krasinskas, MD, Stuart J. Knechtle, MD, and Hyun S. Kim, MD

Subjects
Surgery, RD1-811
Abstract

Background. Infiltrative hepatocellular carcinoma with macrovascular invasion is a relatively rare presentation and usually fatal disease. Methods. Both patients exceeded Milan and University of California-San Francisco (UCSF) criteria, and per Barcelona Clinic Liver Cancer group guidelines, they were enrolled in a prospective open-label radioembolization phase II trial that gave them optimized lobar doses of Yttrium-90 as solely the first-line therapy without concomitant or additional pharmacological or locoregional therapies. Results. Three months after radioembolization, the patients demonstrated no residual viable disease on surveillance imaging. The patients were then followed up with serial imaging for 2 years in 3-month intervals, without documenting recurrence or extrahepatic disease. Finally, both patients underwent transplantation and after more than 20 months of imaging surveillance, no locoregional or systemic recurrence have been observed. Conclusions. We present, to our knowledge, the first 2 reports of transplantation after successfully downstaging infiltrative disease with portal vein tumoral thrombosis, which traditionally poses as a relative contraindication for resection or transplantation.

Published
2017
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39. Pancreatic Ductal Adenocarcinoma is Spread to the Peripancreatic Soft Tissue in the Majority of Resected Cases, Rendering the AJCC T-Stage Protocol (7th Edition) Inapplicable and Insignificant: A Size-Based Staging System (pT1: ≤2, pT2: >2–≤4, pT3: >4 cm) is More Valid and Clinically Relevant

Author

Saka, Burcu, Balci, Serdar, Basturk, Olca, Bagci, Pelin, Postlewait, Lauren M., Maithel, Shishir, Knight, Jessica, El-Rayes, Bassel, Kooby, David, Sarmiento, Juan, Muraki, Takashi, Oliva, Irma, Bandyopadhyay, Sudeshna, Akkas, Gizem, Goodman, Michael, Reid, Michelle D., Krasinskas, Alyssa, Everett, Rhonda, and Adsay, Volkan

Published
2016
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46. Hepatobiliary Mucinous Cystic Neoplasms With Ovarian Type Stroma (So-Called “Hepatobiliary Cystadenoma/Cystadenocarcinoma”): Clinicopathologic Analysis of 36 Cases Illustrates Rarity of Carcinomatous Change

Author

Quigley, Brian, Reid, Michelle D., Pehlivanoglu, Burcin, Squires, Malcolm H., III, Maithel, Shishir, Xue, Yue, Hyejeong, Choi, Akkas, Gizem, Muraki, Takashi, Kooby, David A., Sarmiento, Juan M., Cardona, Ken, Sekhar, Aarti, Krasinskas, Alyssa, and Adsay, Volkan

Published
2018
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50. Reflux-Associated Cholecystopathy: Analysis of 76 Gallbladders From Patients With Supra-Oddi Union of the Pancreatic Duct and Common Bile Duct (Pancreatobiliary Maljunction) Elucidates a Specific Diagnostic Pattern of Mucosal Hyperplasia as a Prelude to Carcinoma

Author

Muraki, Takashi, Memis, Bahar, Reid, Michelle D., Uehara, Takeshi, Ito, Tetsuya, Hasebe, Osamu, Okaniwa, Shinji, Horigome, Naoto, Hisa, Takeshi, Mittal, Pardeep, Freedman, Alexa, Maithel, Shishir, Sarmiento, Juan M., Krasinskas, Alyssa, Koshiol, Jill, and Adsay, Volkan

Published
2017
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