266 results on '"Kranc, Kamil"'
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2. The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia
3. Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death
4. Haematopoietic stem cell health in sickle cell disease and its implications for stem cell therapies and secondary haematological disorders
5. Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation
6. m6A RNA modifications: Key regulators of normal and malignant hematopoiesis
7. MYC sensitises cells to apoptosis by driving energetic demand
8. NANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells
9. JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells
10. A time- and single-cell-resolved model of murine bone marrow hematopoiesis
11. Author Correction: Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation
12. Hypoxia-inducible factor 1 (HIF-1) is a new therapeutic target in JAK2V617F-positive myeloproliferative neoplasms
13. Haematopoietic stem cell health in sickle cell disease and its implications for stem cell therapies and secondary haematological disorders
14. 3051 – SEQUENTIAL SPECIFICATION OF EMBRYO-LIKE HEMATOPOIETIC WAVES IN A HEMOGENIC GASTRULOID MODEL ABLE TO ENGRAFT HEMATOPOIETIC TISSUES
15. hsa-mir183/EGR1–mediated regulation of E2F1 is required for CML stem/progenitor cell survival
16. Systemic silencing of Phd2 causes reversible immune regulatory dysfunction
17. SCD inhibition eradicates AML displaying high de novo fatty acid desaturation and synergizes with chemotherapy
18. The role of Cited2 in cellular proliferation
19. Immunodeficient NBSGW mouse strain allows chemotherapy modeling in AML patient-derived xenografts.
20. Abstract 447: Genetic and pharmacological inhibition of TUT4 and TUT7 sensitizes AML cells to BCL-2 inhibition
21. CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells
22. 3173 – INTRAVITAL MICROSCOPY OF HIGHLY PURE HAEMATOPOIETIC STEM CELLS USING A NOVEL TRANSGENIC REPORTER STRATEGY UNCOVERS UNEXPECTED INTERACTION DYNAMICS WITHIN THE STEM CELL NICHE
23. HOXA9 and β-catenin safeguard HSC integrity
24. Inhibition of Stearoyl-CoA Desaturase Has Anti-Leukemic Properties in Acute Myeloid Leukemia
25. Genetic and Pharmacological Inhibition of TUT4/TUT7 Sensitizes AML Cells to BCL-2 Inhibition
26. Targeting HIF-Hydroxylases Compromises Disease Initiation and Propagation, and Synergises with Current Therapies to Eliminate Cancer Stem Cells in AML
27. Haemogenic Gastruloids Recapitulate Developmental Haematopoiesis and Provide an Ontogeny-Relevant Context to Dissect the Origins of Infant Leukemia
28. Dissecting infant leukemia developmental origins with a hemogenic gastruloid model
29. CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands
30. MYC sensitises cells to apoptosis by driving energetic demand
31. Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis
32. Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death.
33. A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells
34. Author response: A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells
35. Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence
36. 3009 – THERAPEUTIC TARGETING OF RNA DEGRADATION PATHWAYS- NEW AVENUES FOR INTERVENTION IN ACUTE MYELOID LEUKAEMIA
37. CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation
38. Elevated 2HG does not cause features of tumorigenesis
39. 3106 – A GAIN OF FUNCTION MUTATION IN DNMT3A IMPAIRS HAEMATOPOIESIS
40. Peptidylarginine deiminase IV (PADI4) is not essential for cell-autonomous HSC maintenance and normal haematopoiesis
41. The essential reading list for AML: the m6A transcripts
42. The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function
43. Divide and Rule: Mitochondrial Fission Regulates Quiescence in Hematopoietic Stem Cells
44. T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides
45. Control of autoimmunity by ‘epitope theft’
46. Metabolic and innate immune cues merge into a specific inflammatory response via unfolded proteinresponse (UPR)
47. Functional epistasis on a common MHC haplotype associated with multiple sclerosis
48. Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR
49. CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands
50. Catapulting HSCs into action
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