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1. Evidence for a toroidal magnetic field in the core of 3C 84

Author: Paraschos, G. F., Debbrecht, L. C., Kramer, J. A., Traianou, E., Liodakis, I., Krichbaum, T. P., Kim, J. -Y., Janssen, M., Nair, D. G., Savolainen, T., Ros, E., Bach, U., Hodgson, J. A., Lisakov, M., MacDonald, N. R., and Zensus, J. A.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies
Abstract: The spatial scales of relativistic radio jets, probed by relativistic magneto-hydrodynamic jet launching simulations (RMHDs) and by most very-long-baseline interferometry (VLBI) observations differ by an order of magnitude. Bridging the gap between these RMHD simulations and VLBI observations requires selecting nearby active galactic nuclei (AGN), the parsec-scale region of which can be resolved. 3C 84 is a nearby bright AGN fulfilling the necessary requirements: it is launching a powerful, relativistic jet powered by a central supermassive black hole, while also being very bright. Using 22 GHz global VLBI measurements of 3C 84 we aim to study its sub-parsec region in both total intensity and linear polarisation, to explore the properties of this jet, with a linear resolution of $\sim0.1$ parsec. We test different simulation setups by altering the bulk Lorentz factor $\Gamma$ of the jet, as well as the magnetic field configuration (toroidal, poloidal, helical). We confirm the persistence of a limb brightened structure, which reaches deep into the sub-parsec region. The corresponding electric vector position angles (EVPAs) follow the bulk jet flow inside but tend to be orthogonal to it near the edges. Our state-of-the-art RMHD simulations show that this geometry is consistent with a spine-sheath model, associated with a mildly relativistic flow and a toroidal magnetic field configuration., Comment: 10 pages, 8 figures, accepted for publication in Astronomy and Astrophysics
Published: 2024
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2. Ordered magnetic fields around the 3C 84 central black hole

Author: Paraschos, G. F., Kim, J. -Y., Wielgus, M., Röder, J., Krichbaum, T. P., Ros, E., Agudo, I., Myserlis, I., Moscibrodzka, M., Traianou, E., Zensus, J. A., Blackburn, L., Chan, C. -K., Issaoun, S., Janssen, M., Johnson, M. D., Fish, V. L., Akiyama, K., Alberdi, A., Alef, W., Algaba, J. C., Anantua, R., Asada, K., Azulay, R., Bach, U., Baczko, A. -K., Ball, D., Baloković, M., Barrett, J., Bauböck, M., Benson, B. A., Bintley, D., Blundell, R., Bouman, K. L., Bower, G. C., Boyce, H., Bremer, M., Brinkerink, C. D., Brissenden, R., Britzen, S., Broderick, A. E., Broguiere, D., Bronzwaer, T., Bustamante, S., Byun, D. -Y., Carlstrom, J. E., Ceccobello, C., Chael, A., Chang, D. O., Chatterjee, K., Chatterjee, S., Chen, M. T., Chen, Y., Cheng, X., Cho, I., Christian, P., Conroy, N. S., Conway, J. E., Cordes, J. M., Crawford, T. M., Crew, G. B., Cruz-Osorio, A., Cui, Y., Dahale, R., Davelaar, J., De Laurentis, M., Deane, R., Dempsey, J., Desvignes, G., Dexter, J., Dhruv, V., Doeleman, S. S., Dougal, S., Dzib, S. A., Eatough, R. P., Emami, R., Falcke, H., Farah, J., Fomalont, E., Ford, H. A., Foschi, M., Fraga-Encinas, R., Freeman, W. T., Friberg, P., Fromm, C. M., Fuentes, A., Galison, P., Gammie, C. F., García, R., Gentaz, O., Georgiev, B., Goddi, C., Gold, R., Gómez-Ruiz, A. I., Gómez, J. L., Gu, M., Gurwell, M., Hada, K., Haggard, D., Haworth, K., Hecht, M. H., Hesper, R., Heumann, D., Ho, L. C., Ho, P., Honma, M., Huang, C. L., Huang, L., Hughes, D. H., Ikeda, S., Impellizzeri, C. M. V., Inoue, M., James, D. J., Jannuzi, B. T., Jeter, B., Jaing, W., Jiménez-Rosales, A., Jorstad, S., Joshi, A. V., Jung, T., Karami, M., Karuppusamy, R., Kawashima, T., Keating, G. K., Kettenis, M., Kim, D. -J., Kim, J., Kino, M., Koay, J. Y., Kocherlakota, P., Kofuji, Y., Koch, P. M., Koyama, S., Kramer, C., Kramer, J. A., Kramer, M., Kuo, C. -Y., La Bella, N., Lauer, T. R., Lee, D., Lee, S. -S., Leung, P. K., Levis, A., Li, Z., Lico, R., Lindahl, G., Lindqvist, M., Lisakov, M., Liu, J., Liu, K., Liuzzo, E., Lo, W. -P., Lobanov, A. P., Loinard, L., Lonsdale, C. J., Lowitz, A. E., Lu, R. -S., MacDonald, N. R., Mao, J., Marchili, N., Markoff, S., Marrone, D. P., Marscher, A. P., Martí-Vidal, I., Matsushita, S., Matthews, L. D., Medeiros, L., Menten, K. M., Michalik, D., Mizuno, I., Mizuno, Y., Moran, J. M., Moriyama, K., Mulaudzi, W., Müller, C., Müller, H., Mus, A., Musoke, G., Nadolski, A., Nagai, H., Nagar, N. M., Nakamura, M., Narayanan, G., Natarajan, I., Nathanail, A., Fuentes, S. Navarro, Neilsen, J., Neri, R., Ni, C., Noutsos, A., Nowak, M. A., Oh, J., Okino, H., Olivares, H., Ortiz-León, G. N., Oyama, T., Özel, F., Palumbo, D. C. M., Park, J., Parsons, H., Patel, N., Pen, U. -L., Piétu, V., Plambeck, R., PopStefanija, A., Porth, O., Pötzl, F. M., Prather, B., Preciado-López, J. A., Psaltis, D., Pu, H. -Y., Ramakrishnan, V., Rao, R., Rawlings, M. G., Raymond, A. W., Rezzolla, L., Ricarte, A., Ripperda, B., Roelofs, F., Rogers, A., Romero-Cañizales, C., Roshanineshat, A., Rottmann, H., Roy, A. L., Ruiz, I., Ruszczyk, C., Rygl, K. L. J., Sánchez, S., Sánchez-Argüelles, D., Sánchez-Portal, M., Sasada, M., Satapathy, K., Savolainen, T., Schloerb, F. P., Schonfeld, J., Schuster, K., Shao, L., Shen, Z., Small, D., Sohn, B. W., SooHoo, J., Salas, L. D. Sosapanta, Souccar, K., Sun, H., Tazaki, F., Tetarenko, A. J., Tiede, P., Tilanus, R. P. J., Titus, M., Torne, P., Toscano, T., Trent, T., Trippe, S., Turk, M., van Bemmel, I., van Langevelde, H. J., van Rossum, D. R., Vos, J., Wagner, J., Ward-Thompson, D., Wardle, J., Washington, J. E., Weintroub, J., Wharton, R., Wiik, K., Witzel, G., Wondrak, M. F., Wong, G. N., Wu, Q., Yadlapalli, N., Yamaguchi, P., Yfantis, A., Yoon, D., Young, A., Young, K., Younsi, Z., Yu, W., Yuan, F., Yuan, Y. -F., Zhang, S., Zhao, G. Y., and Zhao, S. -S.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies
Abstract: 3C84 is a nearby radio source with a complex total intensity structure, showing linear polarisation and spectral patterns. A detailed investigation of the central engine region necessitates the use of VLBI above the hitherto available maximum frequency of 86GHz. Using ultrahigh resolution VLBI observations at the highest available frequency of 228GHz, we aim to directly detect compact structures and understand the physical conditions in the compact region of 3C84. We used EHT 228GHz observations and, given the limited (u,v)-coverage, applied geometric model fitting to the data. We also employed quasi-simultaneously observed, multi-frequency VLBI data for the source in order to carry out a comprehensive analysis of the core structure. We report the detection of a highly ordered, strong magnetic field around the central, SMBH of 3C84. The brightness temperature analysis suggests that the system is in equipartition. We determined a turnover frequency of $\nu_m=(113\pm4)$GHz, a corresponding synchrotron self-absorbed magnetic field of $B_{SSA}=(2.9\pm1.6)$G, and an equipartition magnetic field of $B_{eq}=(5.2\pm0.6)$G. Three components are resolved with the highest fractional polarisation detected for this object ($m_\textrm{net}=(17.0\pm3.9)$%). The positions of the components are compatible with those seen in low-frequency VLBI observations since 2017-2018. We report a steeply negative slope of the spectrum at 228GHz. We used these findings to test models of jet formation, propagation, and Faraday rotation in 3C84. The findings of our investigation into different flow geometries and black hole spins support an advection-dominated accretion flow in a magnetically arrested state around a rapidly rotating supermassive black hole as a model of the jet-launching system in the core of 3C84. However, systematic uncertainties due to the limited (u,v)-coverage, however, cannot be ignored., Comment: 15 pages, 6 figures, published in A&A
Published: 2024
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3. Multi-messenger characterization of Mrk 501 during historically low X-ray and $\gamma$-ray activity

Author: MAGIC collaboration, Abe, H., Abe, S., Acciari, V. A., Agudo, I., Aniello, T., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Arcaro, C., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., de Almeida, U. Barres, Barrio, J. A., Batković, I., Baxter, J., González, J. Becerra, Bednarek, W., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bošnjak, Ž., Burelli, I., Busetto, G., Carosi, R., Carretero-Castrillo, M., Castro-Tirado, A. J., Ceribella, G., Chai, Y., Chilingarian, A., Cikota, S., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Del Popolo, A., Delfino, M., Delgado, J., Mendez, C. Delgado, Depaoli, D., Di Pierro, F., Di Venere, L., Espiñeira, E. Do Souto, Prester, D. Dominis, Donini, A., Dorner, D., Doro, M., Elsaesser, D., Emery, G., Escudero, J., Ramazani, V. Fallah, Fariña, L., Fattorini, A., Foffano, L., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., López, R. J. García, Garczarczyk, M., Gasparyan, S., Gaug, M., Paiva, J. G. Giesbrecht, Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Grau, R., Green, D., Green, J. G., Hadasch, D., Hahn, A., Hassan, T., Heckmann, L., Herrera, J., Hrupec, D., Hütten, M., Imazawa, R., Inada, T., Iotov, R., Ishio, K., Martínez, I. Jiménez, Jormanainen, J., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Lorini, A., Lyard, E., Fraga, B. Machado de Oliveira, Majumdar, P., Makariev, M., Maneva, G., Mang, N., Manganaro, M., Mangano, S., Mannheim, K., Mariotti, M., Martínez, M., Mas-Aguilar, A., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Mondal, H. A., Moralejo, A., Morcuende, D., Moreno, V., Nakamori, T., Nanci, C., Nava, L., Neustroev, V., Rosillo, M. Nievas, Nigro, C., Nilsson, K., Nishijima, K., Ekoume, T. Njoh, Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Okumura, A., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Persic, M., Pihet, M., Pirola, G., Podobnik, F., Moroni, P. G. Prada, Prandini, E., Principe, G., Priyadarshi, C., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schmuckermaier, F., Schubert, J. L., Schweizer, T., Sitarek, J., Sliusar, V., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Tajima, H., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terauchi, K., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Acosta, M. Vazquez, Ventura, S., Verguilov, V., Viale, I., Vigorito, C. F., Vitale, V., Vovk, I., Walter, R., Will, M., Wunderlich, C., Yamamoto, T., Zarić, D., groups, Other, collaborations, Cerruti, M., Acosta-Pulido, J. A., Apolonio, G., Bachev, R., Baloković, M., Benítez, E., Björklund, I., Bozhilov, V., Brown, L. F., Bugg, A., Carbonell, W., Carnerero, M. I., Carosati, D., Casadio, C., Chamani, W., Chen, W. P., Chigladze, R. A., Damljanovic, G., Epps, K., Erkenov, A., Feige, M., Finke, J., Fuentes, A., Gazeas, K., Giroletti, M., Grishina, T. S., Gupta, A. C., Gurwell, M. A., Heidemann, E., Hiriart, D., Hou, W. J., Hovatta, T., Ibryamov, S., Joner, M. D., Jorstad, S. G., Kania, J., Kiehlmann, S., Kimeridze, G. N., Kopatskaya, E. N., Kopp, M., Korte, M., Kotas, B., Koyama, S., Kramer, J. A., Kunkel, L., Kurtanidze, S. O., Kurtanidze, O. M., Lähteenmäki, A., López, J. M., Larionov, V. M., Larionova, E. G., Larionova, L. V., Leto, C., Lorey, C., Mújica, R., Madejski, G. M., Marchili, N., Marscher, A. P., Minev, M., Modaressi, A., Morozova, D. A., Mufakharov, T., Myserlis, I., Nikiforova, A. A., Nikolashvili, M. G., Ovcharov, E., Perri, M., Raiteri, C. M., Readhead, A. C. S., Reimer, A., Reinhart, D., Righini, S., Rosenlehner, K., Sadun, A. C., Savchenko, S. S., Scherbantin, A., Schneider, L., Schoch, K., Seifert, D., Semkov, E., Sigua, L. A., Singh, C., Sola, P., Sotnikova, Y., Spencer, M., Steineke, R., Stojanovic, M., Strigachev, A., Tornikoski, M., Traianou, E., Tramacere, A., Troitskaya, Yu. V., Troitskiy, I. S., Trump, J. B., Tsai, A., Valcheva, A., Vasilyev, A. A., Verrecchia, F., Villata, M., Vince, O., Vrontaki, K., Weaver, Z. R., Zaharieva, E., and Zottmann, N.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We study the broadband emission of Mrk 501 using multi-wavelength observations from 2017 to 2020 performed with a multitude of instruments, involving, among others, MAGIC, Fermi-LAT, NuSTAR, Swift, GASP-WEBT, and OVRO. Mrk 501 showed an extremely low broadband activity, which may help to unravel its baseline emission. Nonetheless, significant flux variations are detected at all wavebands, with the highest occurring at X-rays and very-high-energy (VHE) $\gamma$-rays. A significant correlation ($>$3$\sigma$) between X-rays and VHE $\gamma$-rays is measured, supporting leptonic scenarios to explain the variable parts of the emission, also during low activity. This is further supported when we extend our data from 2008 to 2020, and identify, for the first time, significant correlations between Swift-XRT and Fermi-LAT. We additionally find correlations between high-energy $\gamma$-rays and radio, with the radio lagging by more than 100 days, placing the $\gamma$-ray emission zone upstream of the radio-bright regions in the jet. Furthermore, Mrk 501 showed a historically low activity in X-rays and VHE $\gamma$-rays from mid-2017 to mid-2019 with a stable VHE flux ($>$0.2 TeV) of 5% the emission of the Crab Nebula. The broadband spectral energy distribution (SED) of this 2-year-long low-state, the potential baseline emission of Mrk 501, can be characterized with one-zone leptonic models, and with (lepto)-hadronic models fulfilling neutrino flux constraints from IceCube. We explore the time evolution of the SED towards the low-state, revealing that the stable baseline emission may be ascribed to a standing shock, and the variable emission to an additional expanding or traveling shock., Comment: 55 pages, 30 figures, 14 tables, accepted by APJS. Corresponding authors are L. Heckmann, D. Paneque, S. Gasparyan, M. Cerruti, and N. Sahakyan
Published: 2022
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4. High Polygenic Risk Scores Are Associated With Early Age of Onset of Alcohol Use Disorder in Adolescents and Young Adults at Risk

Author: Nurnberger, John I, Wang, Yumin, Zang, Yong, Lai, Dongbing, Wetherill, Leah, Edenberg, Howard J, Aliev, Fazil, Plawecki, Martin H, Chorlian, David, Chan, Grace, Bucholz, Kathleen, Bauer, Lance, Kamarajan, Chella, Salvatore, Jessica E, Kapoor, Manav, Hesselbrock, Victor, Dick, Danielle, Bierut, Laura, McCutcheon, Vivia, Meyers, Jacquelyn L, Porjesz, Bernice, Kramer, John, Kuperman, Samuel, Kinreich, Sivan, Anokhin, Andrey P, Porjesz, B, Hesselbrock, V, Foroud, T, Agrawal, A, Dick, D, Edenberg, HJ, Nurnberger, J, Liu, Y, Kuperman, S, Kramer, J, Meyers, J, Kamarajan, C, Pandey, A, Bierut, L, Rice, J, Bucholz, K, Schuckit, M, Tischfield, J, Brooks, A, Hart, R, Almasy, L, Salvatore, J, Goate, A, Kapoor, M, Slesinger, P, Scott, D, Bauer, L, Wetherill, L, Xuei, X, Lai, D, O’Connor, S, Plawecki, M, Zang, Y, Acion, L, Chan, G, Chorlian, DB, Zhang, J, Kinreich, S, Pandey, G, Chao, M, Anokhin, A, McCutcheon, V, Saccone, S, Aliev, F, Barr, P, Chin, H, and Parsian, A
Subjects: Biological Sciences, Biomedical and Clinical Sciences, Genetics, Epidemiology, Health Sciences, Prevention, Substance Misuse, Underage Drinking, Alcoholism, Alcohol Use and Health, Pediatric, Clinical Research, Mental health, Good Health and Well Being, Collaborative Study on the Genetics of Alcoholism, Alcohol use disorder, Clinical variables, Polygenic risk scores, Prediction of illness, Receiver operating characteristics curves, Survival analysis
Abstract: BackgroundGenome-wide association studies have been conducted in alcohol use disorder (AUD), and they permit the use of polygenic risk scores (PRSs), in combination with clinical variables, to predict the onset of AUD in vulnerable populations.MethodsA total of 2794 adolescent/young adult subjects from the Collaborative Study on the Genetics of Alcoholism were followed, with clinical assessments every 2 years. Subjects were genotyped using a genome-wide chip. Separate PRS analyses were performed for subjects of European ancestry and African ancestry. Age of onset of DSM-5 AUD was evaluated using the Cox proportional hazard model. Predictive power was assessed using receiver operating characteristic curves and by analysis of the distribution of PRS.ResultsEuropean ancestry subjects with higher than median PRSs were at greater risk for onset of AUD than subjects with lower than median PRSs (p = 3 × 10-7). Area under the curve for the receiver operating characteristic analysis peaked at 0.88 to 0.95 using PRS plus sex, family history, comorbid disorders, age at first drink, and peer drinking; predictive power was primarily driven by clinical variables. In this high-risk sample, European ancestry subjects with a PRS score in the highest quartile showed a 72% risk for developing AUD and a 35% risk of developing severe AUD (compared with risks of 54% and 16%, respectively, in the lowest quartile).ConclusionsPredictive power for PRSs in the extremes of the distribution suggests that these may have future clinical utility. Uncertainties in interpretation at the individual level still preclude current application.
Published: 2022

5. Leveraging Color M-Mode to Diagnose Aorto-Atrial Fistula as a Complication of Infective Endocarditis

Author: Kramer J. Wahlberg, Matthew A. Kluge, and William E. Hopkins
Subjects: Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Aorto-atrial fistula is a rare and life-threatening complication of infective endocarditis, classically diagnosed by visualizing a connection between the aorta and atrium with associated continuous flow. A patient presented with bioprosthetic and native valve enterococcal endocarditis with multiple complications, including an aorto-atrial fistula that was diagnosed by color M-mode on transesophageal echocardiography. We review the features of aorto-atrial fistula and utilize this case to demonstrate how M-mode can be leveraged to provide improved temporal resolution in the setting of diagnostic uncertainty.
Published: 2024
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6. Effects of Continuous Accelerated Pacing on Cardiac Structure and Function in Patients With Heart Failure With Preserved Ejection Fraction: Insights From the myPACE Randomized Clinical Trial

Author: Kramer J. Wahlberg, Margaret Infeld, Timothy B. Plante, Alexandra E. Novelli, Nicole Habel, Daniel Burkhoff, Trace Barrett, Daniel Lustgarten, and Markus Meyer
Subjects: HFpEF, pacing, ventricular remodeling, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Background Heart failure with preserved ejection fraction ≥50% is prevalent with few evidence‐based therapies. In a trial of patients with heart failure with preserved ejection fraction with specialized pacemakers, treatment with accelerated personalized pacing averaging 75 bpm (myPACE) markedly improved quality of life, NT‐proBNP (N‐terminal pro–brain natriuretic peptide), physical activity, and atrial fibrillation burden compared with the standard lower rate setting of 60 bpm (usual care). Methods and Results In this exploratory study, provider‐initiated echocardiographic studies obtained before and after the trial were assessed for changes in left ventricular (LV) structure and function among participants who continued their pacing assignment. The analytic approach aimed to detect differences in standard and advanced echocardiographic parameters within and between study arms. Of the 100 participants, 16 myPACE and 20 usual care arm had a qualifying set of echocardiograms performed a mean (SD) 3 (2.0) years apart. Despite similar baseline echocardiogram measures, sustained exposure to moderately accelerated pacing resulted in reduced septal wall thickness (in cm: myPACE 1.1 [0.2] versus usual care 1.2 [0.2], P=0.008) and lower LV mass to systolic volume ratio (in g/mL: myPACE 4.8 [1.9] versus usual care 6.8 [3.1], P=0.038) accompanied by a minor reduction in LV ejection fraction (in %: myPACE 55 [5] versus usual care 60 [5], P=0.015). These changes were paralleled by improvements in heart failure‐related quality of life (myPACE Minnesota Living with Heart Failure Questionnaire improved by 16.1 [13.9] points, whereas usual care worsened by 6.9 [11.6] points, P
Published: 2024
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7. Development, Feasibility, and Initial Evaluation of an Active Learning Module for Teaching Pediatric ECG Interpretation and Entrustable Professional Activities to Clinical Medical Students

Author: Holland, Jennifer E., Rohwer, James K., O'Connor, Julia M., Wahlberg, Kramer J., DeSarno, Michael, Hopkins, William E., and Flyer, Jonathan N.
Published: 2023
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8. Abstract 17940: Effects of Continuous Accelerated Pacing on Clinical Outcomes in Patients With Heart Failure With Preserved Ejection Fraction: Three Year Follow Up of the myPACE Randomized Clinical Trial

Author: Infeld, Margaret, Cyr, Jamie, Novelli, Alexandra, Wahlberg, Kramer J, Rawlings, Rebecca, Plante, Tim B, and Meyer, Markus
Published: 2023
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9. Abstract 14093: Effects of Continuous Accelerated Pacing on Cardiac Structure and Function in Patients With Heart Failure With Preserved Ejection Fraction: Insights From the MyPACE Randomized Clinical Trial

Author: Wahlberg, Kramer J, Infeld, Margaret, Plante, Tim B, Novelli, Alexandra E, Habel, Nicole, Barrett, Trace, and Meyer, Markus
Published: 2023
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10. Towards a Transportable Aluminium Ion Quantum Logic Optical Clock

Author: Hannig, S., Pelzer, L., Scharnhorst, N., Kramer, J., Stepanova, M., Xu, Z. T., Spethmann, N., Leroux, I. D., Mehlstäubler, T. E., and Schmidt, P. O.
Subjects: Physics - Atomic Physics
Abstract: With the advent of optical clocks featuring fractional frequency uncertainties on the order of $10^{-17}$ and below, new applications such as chronometric levelling with few-cm height resolution emerge. We are developing a transportable optical clock based on a single trapped aluminium ion, which is interrogated via quantum logic spectroscopy. We employ singly-charged calcium as the logic ion for sympathetic cooling, state preparation and readout. Here we present a simple and compact physics and laser package for manipulation of $^{40}\mathrm{Ca}^+$. Important features are a segmented multi-layer trap with separate loading and probing zones, a compact titanium vacuum chamber, a near-diffraction-limited imaging system with high numerical aperture based on a single biaspheric lens, and an all-in-fiber $^{40}\mathrm{Ca}^+$ repump laser system. We present preliminary estimates of the trap-induced frequency shifts on $^{27}\mathrm{Al}^+$, derived from measurements with a single calcium ion. The micromotion-induced second-order Doppler shift for $^{27}\mathrm{Al}^+$ has been determined to be \sods and the black-body radiation shift is $\delta\nu_\mathrm{BBR}/\nu=(-4.0\pm0.4)\times10^{-18}$. Moreover, heating rates of 30 (7) quanta per second at trap frequencies of $\omega_\mathrm{rad,Ca+} \approx2\pi\times2.5\,\mathrm{MHz}$ ($\omega_\mathrm{ax,Ca+} \approx2\pi\times1.5\,\mathrm{MHz}$) in radial (axial) direction have been measured, enabling interrogation times of a few hundreds of milliseconds., Comment: 14 pages, 17 figures
Published: 2019
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11. Validation Of A Nonlinear Wave Decompistion Method Including Shoaling

Author: DE RIDDER, M.P., primary, KRAMER, J., additional, and DEN BIEMAN, J.P., additional
Published: 2024
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12. Risk assessment of SARS-CoV-2 transmission in hospitality employees in a highly frequented tourist area

Author: Thiessen, H., Käding, N., Gebel, B., Borsche, M., Graspeuntner, S., Kirchhoff, L., Ehlers, M., Rahmöller, J., Taube, S., Kramer, J., Klein, C., Katalinic, A., and Rupp, J.
Published: 2022
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13. Erratum.

Author: Schuckit, MA, Smith, TL, Danko, G, Kramer, J, Bucholz, KK, McCutcheon, V, Chan, G, Kuperman, S, Hesselbrock, V, Dick, DM, Hesselbrock, M, Porjesz, B, Edenberg, HJ, Jr, Nurnberger John I, Gregg, M, Schoen, L, Kawamura, M, and Mendoza, LA
Subjects: Substance Abuse, Clinical Sciences, Psychology, Neurosciences
Published: 2018

14. High Polygenic Risk Scores Are Associated With Early Age of Onset of Alcohol Use Disorder in Adolescents and Young Adults at Risk

Author: Porjesz, B., Hesselbrock, V., Foroud, T., Agrawal, A., Dick, D., Edenberg, H.J., Nurnberger, J., Jr., Liu, Y., Kuperman, S., Kramer, J., Meyers, J., Kamarajan, C., Pandey, A., Bierut, L., Rice, J., Bucholz, K., Schuckit, M., Tischfield, J., Brooks, A., Hart, R., Almasy, L., Salvatore, J., Goate, A., Kapoor, M., Slesinger, P., Scott, D., Bauer, L., Wetherill, L., Xuei, X., Lai, D., O’Connor, S., Plawecki, M., Zang, Y., Acion, L., Chan, G., Chorlian, D.B., Zhang, J., Kinreich, S., Pandey, G., Chao, M., Anokhin, A., McCutcheon, V., Saccone, S., Aliev, F., Barr, P., Chin, H., Parsian, A., Nurnberger, John I., Jr., Wang, Yumin, Zang, Yong, Lai, Dongbing, Wetherill, Leah, Edenberg, Howard J., Aliev, Fazil, Plawecki, Martin H., Chorlian, David, Chan, Grace, Bucholz, Kathleen, Bauer, Lance, Kamarajan, Chella, Salvatore, Jessica E., Kapoor, Manav, Hesselbrock, Victor, Dick, Danielle, Bierut, Laura, McCutcheon, Vivia, Meyers, Jacquelyn L., Porjesz, Bernice, Kramer, John, Kuperman, Samuel, Kinreich, Sivan, and Anokhin, Andrey P.
Published: 2022
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15. Improved acquisition of contact heat evoked potentials with increased heating ramp

Author: De Schoenmacker, I., Archibald, J., Kramer, J. L. K., and Hubli, M.
Published: 2022
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16. Assured automatic dynamic reconfiguration of business processes

Author: Nahabedian, L., Braberman, V., D’Ippolito, N., Kramer, J., and Uchitel, S.
Published: 2022
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17. Ordered magnetic fields around the 3C 84 central black hole

Author: Paraschos, G. F., primary, Kim, J.-Y., additional, Wielgus, M., additional, Röder, J., additional, Krichbaum, T. P., additional, Ros, E., additional, Agudo, I., additional, Myserlis, I., additional, Moscibrodzka, M., additional, Traianou, E., additional, Zensus, J. A., additional, Blackburn, L., additional, Chan, C.-K., additional, Issaoun, S., additional, Janssen, M., additional, Johnson, M. D., additional, Fish, V. L., additional, Akiyama, K., additional, Alberdi, A., additional, Alef, W., additional, Algaba, J. C., additional, Anantua, R., additional, Asada, K., additional, Azulay, R., additional, Bach, U., additional, Baczko, A.-K., additional, Ball, D., additional, Baloković, M., additional, Barrett, J., additional, Bauböck, M., additional, Benson, B. A., additional, Bintley, D., additional, Blundell, R., additional, Bouman, K. L., additional, Bower, G. C., additional, Boyce, H., additional, Bremer, M., additional, Brinkerink, C. D., additional, Brissenden, R., additional, Britzen, S., additional, Broderick, A. E., additional, Broguiere, D., additional, Bronzwaer, T., additional, Bustamante, S., additional, Byun, D.-Y., additional, Carlstrom, J. E., additional, Ceccobello, C., additional, Chael, A., additional, Chang, D. O., additional, Chatterjee, K., additional, Chatterjee, S., additional, Chen, M. T., additional, Chen, Y., additional, Cheng, X., additional, Cho, I., additional, Christian, P., additional, Conroy, N. S., additional, Conway, J. E., additional, Cordes, J. M., additional, Crawford, T. M., additional, Crew, G. B., additional, Cruz-Osorio, A., additional, Cui, Y., additional, Dahale, R., additional, Davelaar, J., additional, De Laurentis, M., additional, Deane, R., additional, Dempsey, J., additional, Desvignes, G., additional, Dexter, J., additional, Dhruv, V., additional, Doeleman, S. S., additional, Dougal, S., additional, Dzib, S. A., additional, Eatough, R. P., additional, Emami, R., additional, Falcke, H., additional, Farah, J., additional, Fomalont, E., additional, Ford, H. A., additional, Foschi, M., additional, Fraga-Encinas, R., additional, Freeman, W. T., additional, Friberg, P., additional, Fromm, C. M., additional, Fuentes, A., additional, Galison, P., additional, Gammie, C. F., additional, García, R., additional, Gentaz, O., additional, Georgiev, B., additional, Goddi, C., additional, Gold, R., additional, Gómez-Ruiz, A. I., additional, Gómez, J. L., additional, Gu, M., additional, Gurwell, M., additional, Hada, K., additional, Haggard, D., additional, Haworth, K., additional, Hecht, M. H., additional, Hesper, R., additional, Heumann, D., additional, Ho, L. C., additional, Ho, P., additional, Honma, M., additional, Huang, C. L., additional, Huang, L., additional, Hughes, D. H., additional, Ikeda, S., additional, Impellizzeri, C. M. V., additional, Inoue, M., additional, James, D. J., additional, Jannuzi, B. T., additional, Jeter, B., additional, Jaing, W., additional, Jiménez-Rosales, A., additional, Jorstad, S., additional, Joshi, A. V., additional, Jung, T., additional, Karami, M., additional, Karuppusamy, R., additional, Kawashima, T., additional, Keating, G. K., additional, Kettenis, M., additional, Kim, D.-J., additional, Kim, J., additional, Kino, M., additional, Koay, J. Y., additional, Kocherlakota, P., additional, Kofuji, Y., additional, Koch, P. M., additional, Koyama, S., additional, Kramer, C., additional, Kramer, J. A., additional, Kramer, M., additional, Kuo, C.-Y., additional, La Bella, N., additional, Lauer, T. R., additional, Lee, D., additional, Lee, S.-S., additional, Leung, P. K., additional, Levis, A., additional, Li, Z., additional, Lico, R., additional, Lindahl, G., additional, Lindqvist, M., additional, Lisakov, M., additional, Liu, J., additional, Liu, K., additional, Liuzzo, E., additional, Lo, W.-P., additional, Lobanov, A. P., additional, Loinard, L., additional, Lonsdale, C. J., additional, Lowitz, A. E., additional, Lu, R.-S., additional, MacDonald, N. R., additional, Mao, J., additional, Marchili, N., additional, Markoff, S., additional, Marrone, D. P., additional, Marscher, A. P., additional, Martí-Vidal, I., additional, Matsushita, S., additional, Matthews, L. D., additional, Medeiros, L., additional, Menten, K. M., additional, Michalik, D., additional, Mizuno, I., additional, Mizuno, Y., additional, Moran, J. M., additional, Moriyama, K., additional, Mulaudzi, W., additional, Müller, C., additional, Müller, H., additional, Mus, A., additional, Musoke, G., additional, Nadolski, A., additional, Nagai, H., additional, Nagar, N. M., additional, Nakamura, M., additional, Narayanan, G., additional, Natarajan, I., additional, Nathanail, A., additional, Navarro Fuentes, S., additional, Neilsen, J., additional, Neri, R., additional, Ni, C., additional, Noutsos, A., additional, Nowak, M. A., additional, Oh, J., additional, Okino, H., additional, Olivares, H., additional, Ortiz-León, G. N., additional, Oyama, T., additional, Özel, F., additional, Palumbo, D. C. M., additional, Park, J., additional, Parsons, H., additional, Patel, N., additional, Pen, U.-L., additional, Piétu, V., additional, Plambeck, R., additional, PopStefanija, A., additional, Porth, O., additional, Pötzl, F. M., additional, Prather, B., additional, Preciado-López, J. A., additional, Psaltis, D., additional, Pu, H.-Y., additional, Ramakrishnan, V., additional, Rao, R., additional, Rawlings, M. G., additional, Raymond, A. W., additional, Rezzolla, L., additional, Ricarte, A., additional, Ripperda, B., additional, Roelofs, F., additional, Rogers, A., additional, Romero-Cañizales, C., additional, Roshanineshat, A., additional, Rottmann, H., additional, Roy, A. L., additional, Ruiz, I., additional, Ruszczyk, C., additional, Rygl, K. L. J., additional, Sánchez, S., additional, Sánchez-Argüelles, D., additional, Sánchez-Portal, M., additional, Sasada, M., additional, Satapathy, K., additional, Savolainen, T., additional, Schloerb, F. P., additional, Schonfeld, J., additional, Schuster, K., additional, Shao, L., additional, Shen, Z., additional, Small, D., additional, Sohn, B. W., additional, SooHoo, J., additional, Sosapanta Salas, L. D., additional, Souccar, K., additional, Sun, H., additional, Tazaki, F., additional, Tetarenko, A. J., additional, Tiede, P., additional, Tilanus, R. P. J., additional, Titus, M., additional, Torne, P., additional, Toscano, T., additional, Trent, T., additional, Trippe, S., additional, Turk, M., additional, van Bemmel, I., additional, van Langevelde, H. J., additional, van Rossum, D. R., additional, Vos, J., additional, Wagner, J., additional, Ward-Thompson, D., additional, Wardle, J., additional, Washington, J. E., additional, Weintroub, J., additional, Wharton, R., additional, Wiik, K., additional, Witzel, G., additional, Wondrak, M. F., additional, Wong, G. N., additional, Wu, Q., additional, Yadlapalli, N., additional, Yamaguchi, P., additional, Yfantis, A., additional, Yoon, D., additional, Young, A., additional, Young, K., additional, Younsi, Z., additional, Yu, W., additional, Yuan, F., additional, Yuan, Y.-F., additional, Zhang, S., additional, Zhao, G. Y., additional, and Zhao, S.-S., additional
Published: 2024
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18. Impact of an institutional grant award on early career investigator applicants and peer reviewers

Author: Mughal, Amreen, Wahlberg, Kramer J., Li, Zhaojin, Flyer, Jonathan N., Olson, Nels C., and Cushman, Mary
Published: 2021
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19. How can we reach long-lasting inclusive participation for all? : A vision for the future

Author: Ullenhag, A., Imms, C., Anaby, D., Kramer, J. M., Girdler, S., Gorter, J. W., Ketelaar, M., Jahnsen, R. B., Elliott, C., Granlund, Mats, Ullenhag, A., Imms, C., Anaby, D., Kramer, J. M., Girdler, S., Gorter, J. W., Ketelaar, M., Jahnsen, R. B., Elliott, C., and Granlund, Mats
Abstract: In 2022, an international conference was held focusing on ‘participation’. We shared current evidence, identified knowledge gaps and worked together to understand what new knowledge and community and practice changes were needed. This brief communication is a summary of the conference delegates' discussions. We present the key assumptions we make about participation and propose what is needed to create change for societies, communities, families and individuals. While we have some robust evidence to support participation approaches, more is needed, and it is everyone's responsibility to build an inclusive society where participation for all is the reality.
Published: 2024
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20. The relationship between cognitive and behavioral measures of executive function in the context of elementary school.

Author: Kramer, J. and Kramer, J.
Subjects: Neuropsychology and rehabilitation psychology., Social Development., Neuro- en revalidatiepsychologie.
Published: 2024

21. Leveraging Color M-Mode to Diagnose Aorto-Atrial Fistula as a Complication of Infective Endocarditis.

Author: Wahlberg, Kramer J., Kluge, Matthew A., and Hopkins, William E.
Subjects: *INFECTIVE endocarditis, *FISTULA, *TRANSESOPHAGEAL echocardiography, *BIOPROSTHETIC heart valves, *DIAGNOSIS, *ATRIUMS (Architecture)
Abstract: Aorto-atrial fistula is a rare and life-threatening complication of infective endocarditis, classically diagnosed by visualizing a connection between the aorta and atrium with associated continuous flow. A patient presented with bioprosthetic and native valve enterococcal endocarditis with multiple complications, including an aorto-atrial fistula that was diagnosed by color M-mode on transesophageal echocardiography. We review the features of aorto-atrial fistula and utilize this case to demonstrate how M-mode can be leveraged to provide improved temporal resolution in the setting of diagnostic uncertainty. [ABSTRACT FROM AUTHOR]
Published: 2024
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22. Effect of Paced Heart Rate on Quality of Life and Natriuretic Peptides for Stage B or C HFpEF: A Secondary Analysis of the myPACE Trial

Author: de la Espriella, Rafael, primary, Wahlberg, Kramer J, additional, Infeld, Margaret, additional, Palau, Patricia, additional, Núñez, Eduardo, additional, Sanchis, Juan, additional, Meyer, Markus, additional, and Núñez, Julio, additional
Published: 2023
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23. Effective bounds for Faltings's delta function

Author: Jorgenson, J. and Kramer, J.
Subjects: Mathematics - Number Theory
Abstract: We obtain bounds for the Faltings's delta function for any Riemann surface of genus greater than one. The bounds are in terms of the genus of the surface and two basic quantities coming from hyperbolic geometry: The length of the shortest closed geodesic, and the smallest non-zero eigenvalue of the Laplacian which acts on smooth functions. In the case when the surface in question is a finite degree cover of a fixed base surface, then bounds are given in terms of the degree of the curve and data associated to the base surface.
Published: 2013

24. Genome-wide association data suggest ABCB1 and immune-related gene sets may be involved in adult antisocial behavior.

Author: Salvatore, JE, Edwards, AC, McClintick, JN, Bigdeli, TB, Adkins, A, Aliev, F, Edenberg, HJ, Foroud, T, Hesselbrock, V, Kramer, J, Nurnberger, JI, Schuckit, M, Tischfield, JA, Xuei, X, and Dick, DM
Subjects: Brain, Humans, Alcoholism, Cocaine-Related Disorders, Genetic Predisposition to Disease, P-Glycoproteins, Interferon Type I, Case-Control Studies, Antisocial Personality Disorder, Polymorphism, Single Nucleotide, Adult, Female, Male, Genome-Wide Association Study, ATP Binding Cassette Transporter, Subfamily B, Human Genome, Substance Abuse, Brain Disorders, Mental Health, Genetics, Violence Research, Polymorphism, Single Nucleotide, ATP Binding Cassette Transporter, Subfamily B, Psychology, Clinical Sciences, Public Health and Health Services
Abstract: Adult antisocial behavior (AAB) is moderately heritable, relatively common and has adverse consequences for individuals and society. We examined the molecular genetic basis of AAB in 1379 participants from a case-control study in which the cases met criteria for alcohol dependence. We also examined whether genes of interest were expressed in human brain. AAB was measured using a count of the number of Antisocial Personality Disorder criteria endorsed under criterion A from the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV). Participants were genotyped on the Illumina Human 1M BeadChip. In total, all single-nucleotide polymorphisms (SNPs) accounted for 25% of the variance in AAB, although this estimate was not significant (P=0.09). Enrichment tests indicated that more significantly associated genes were over-represented in seven gene sets, and most were immune related. Our most highly associated SNP (rs4728702, P=5.77 × 10(-7)) was located in the protein-coding adenosine triphosphate-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1). In a gene-based test, ABCB1 was genome-wide significant (q=0.03). Expression analyses indicated that ABCB1 was robustly expressed in the brain. ABCB1 has been implicated in substance use, and in post hoc tests we found that variation in ABCB1 was associated with DSM-IV alcohol and cocaine dependence criterion counts. These results suggest that ABCB1 may confer risk across externalizing behaviors, and are consistent with previous suggestions that immune pathways are associated with externalizing behaviors. The results should be tempered by the fact that we did not replicate the associations for ABCB1 or the gene sets in a less-affected independent sample.
Published: 2015

25. The Hot and Energetic Universe: The X-ray Integral Field Unit (X-IFU) for Athena+

Author: Barret, D., Herder, J. W. den, Piro, L., Ravera, L., Hartog, R. Den, Macculi, C., Barcons, X., Page, M., Paltani, S., Rauw, G., Wilms, J., Ceballos, M., Duband, L., Gottardi, L., Lotti, S., de Plaa, J., Pointecouteau, E., Schmid, C., Akamatsu, H., Bagliani, D., Bandler, S., Barbera, M., Bastia, P., Biasotti, M., Branco, M., Camon, A., Cara, C., Cobo, B., Colasanti, L., Costa-Kramer, J. L., Corcione, L., Doriese, W., Duval, J. M., Fabrega, L., Gatti, F., de Gerone, M., Guttridge, P., Kelley, R., Kilbourne, C., van der Kuur, J., Mineo, T., Mitsuda, K., Natalucci, L., Ohashi, T., Peille, P., Perinati, E., Pigot, C., Pizzigoni, G., Pobes, C., Porter, F., Renotte, E., Sauvageot, J. L., Sciortino, S., Torrioli, G., Valenziano, L., Willingale, D., de Vries, C., and van Weers, H.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The Athena+ mission concept is designed to implement the Hot and Energetic Universe science theme submitted to the European Space Agency in response to the call for White Papers for the definition of the L2 and L3 missions of its science program. The Athena+ science payload consists of a large aperture high angular resolution X-ray optics and twelve meters away, two interchangeable focal plane instruments: the X-ray Integral Field Unit (X-IFU) and the Wide Field Imager (WFI). The X-IFU is a cryogenic X-ray spectrometer, based on a large array of Transition Edge Sensors (TES), offering 2.5 eV spectral resolution, with ~5" pixels, over a field of view of 5 arc minutes in diameter. In this paper, we briefly describe the Athena+ mission concept and the X-IFU performance requirements. We then present the X-IFU detector and readout electronics principles, the current design of the focal plane assembly, the cooling chain and review the global architecture design. Finally, we describe the current performance estimates, in terms of effective area, particle background rejection, count rate capability and velocity measurements. Finally, we emphasize on the latest technology developments concerning TES array fabrication, spectral resolution and readout performance achieved to show that significant progresses are being accomplished towards the demanding X-IFU requirements., Comment: Supporting paper for the science theme "The Hot and Energetic Universe" to be implemented by the Athena+ X-ray observatory (http://www.the-athena-x-ray-observatory.eu). 17 pages, 19 figures
Published: 2013

26. Impact of an institutional grant award on early career investigator applicants and peer reviewers

Author: Amreen Mughal, Kramer J. Wahlberg, Zhaojin Li, Jonathan N. Flyer, Nels C. Olson, and Mary Cushman
Subjects: award, institute, peer review, surveys and questionnaires, writing, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Abstract Background Obtaining research funding support is integral to a successful career in science. Training and practice in grant writing, as well as engagement in peer review of grant applications may help lead to successful research funding. However, there is little evidence on the impact of institutional programs on the career development of early career investigators (ECIs). Objectives Understand the impact of participation in an institutional research award program on the career development of ECIs. Methods The Cardiovascular Research Institute of Vermont established an Early Career Research (ECR) award program in 2018. ECIs who participated as applicants or reviewers in the first 3 years of the program (2018‐2020) were surveyed to understand the impact of the ECR award program on their grant writing and professional development. Results Ninety‐four percent of 17 applicants and 90% of 19 reviewers completed the survey. Ninety‐two percent of funded and 75% of unfunded applicants, and 87% of reviewers reported that the program was beneficial to their professional development. Similarly, 85% of funded applicants, 75% of unfunded applicants, and 80% of reviewers reported improvement in their grant‐writing skills. All respondents reported they would recommend the ECR award program to their peers. Conclusions This single‐institution ECR award program had a positive impact on ECI’s professional development and grant‐writing skills and may lead to further extramural funding opportunities.
Published: 2021
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27. Nuclear spins, magnetic moments and quadrupole moments of Cu isotopes from N = 28 to N = 46: probes for core polarization effects

Author: Vingerhoets, P., Flanagan, K. T., Avgoulea, M., Billowes, J., Bissell, M. L., Blaum, K., Brown, B. A., Cheal, B., De Rydt, M., Forest, D. H., Geppert, Ch., Honma, M., Kowalska, M., Kramer, J., Krieger, A., Mane, E., Neugart, R., Neyens, G., Nortershauser, W., Otsuka, T., Schug, M., Stroke, H. H., Tungate, G., and Yordanov, D. T.
Subjects: Nuclear Experiment
Abstract: Measurements of the ground-state nuclear spins, magnetic and quadrupole moments of the copper isotopes from 61Cu up to 75Cu are reported. The experiments were performed at the ISOLDE facility, using the technique of collinear laser spectroscopy. The trend in the magnetic moments between the N=28 and N=50 shell closures is reasonably reproduced by large-scale shell-model calculations starting from a 56Ni core. The quadrupole moments reveal a strong polarization of the underlying Ni core when the neutron shell is opened, which is however strongly reduced at N=40 due to the parity change between the $pf$ and $g$ orbits. No enhanced core polarization is seen beyond N=40. Deviations between measured and calculated moments are attributed to the softness of the 56Ni core and weakening of the Z=28 and N=28 shell gaps., Comment: 13 pagers, 19 figures, accepted by Physical Review C
Published: 2010
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28. Room-temperature ferromagnetism in the mixtures of the TiO2 and Co3O4 powders

Author: Serrano, A., Pinel, E. Fernandez, Quesada, A., Lorite, I., Plaza, M., Perez, L., Jimenez-Villacorta, F., de la Venta, J., Martin-Gonzalez, M. S., Costa-Kramer, J. L., Fernandez, J. F., Llopis, J., and Garcia, M. A.
Subjects: Condensed Matter - Materials Science
Abstract: We report here the observation of ferromagnetism (FM) at 300 K in mixtures of TiO2 and Co3O4 powders despite the antiferromagnetic and diamagnetic character of both oxides respectively. The ferromagnetic behavior is found in the early stages of reaction and only for TiO2 in anatase structure; no FM is found for identical samples prepared with rutile-TiO2. Optical spectroscopy and X-ray absorption spectra confirm a surface reduction of octahedral Co+3->Co+2 in the mixtures which is in the origin of the observed magnetism, Comment: 17 pages, 8 figures
Published: 2009
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29. Insights into the room temperature magnetism of ZnO/Co3O4 mixtures

Author: Martin-Gonzalez, M. S., Fernandez, J. F., Rubio-Marcos, F., Lorite, I., Costa-Kramer, J. L., Quesada, A., Banares, M. A., and Fierro, J. L. G.
Subjects: Condensed Matter - Materials Science
Abstract: The origin of room temperature (RT) ferromagneticlike behavior in ZnO-based diluted magnetic semiconductors is still an unclear topic. The present work concentrates on the appearance of RT magnetic moments in just mixed ZnO/Co3O4 mixtures without thermal treatment. In this study, it is shown that the magnetism seems to be related to surface reduction of the Co3O4 nanoparticles, in which, an antiferromagnetic Co3O4 nanoparticle (core) is surrounded by a CoO-like shell. This singular superficial magnetism has also been found in other mixtures with semiconductors such as TiO2 and insulators such as Al2O3.
Published: 2009
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30. 228 Pediatric Point-of-Care Ultrasound Training in United States Emergency Medicine Residencies: Is Current Training Adequate?

Author: Shepherd, C., primary, Zang, R., additional, Panebianco, N., additional, Shofer, F., additional, Baraniecki-Zwil, G., additional, Chen, A., additional, Kramer, J., additional, and Rempell, R., additional
Published: 2023
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31. Microbiome modification and improvement of signs and symptoms of COVID-19: Ileocolonic-release nicotinamide in a prospective, double-blind, randomized, placebo-controlled trial

Author: Schreiber, S., additional, Waetzig, G. H., additional, Geisler, C., additional, Schlicht, K., additional, Franzenburg, S., additional, López-Agudelo, V. A., additional, di Giuseppe, R., additional, Pape, D., additional, Bahmer, T., additional, Krawczak, M., additional, Kokott, E., additional, Harzer, O., additional, Kramer, J., additional, von Schrenck, T., additional, Sommer, F., additional, Zacharias, H. U., additional, Heyckendorf, J., additional, Aden, K., additional, Hollweck, R., additional, Laudes, M., additional, and Rosenstiel, P., additional
Published: 2023
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32. Sources of experimental errors in the observation of nanoscale magnetism

Author: Garcia, M. A., Pinel, E. Fernandez, de la Venta, J, Quesada, A., Bouzas, V., Fernandez, J. F., Romero, J. J., Gonzalez, M. S. Martin, and Costa-Kramer, J. L.
Subjects: Condensed Matter - Materials Science
Abstract: It has been recently reported that some non-magnetic materials in bulk state, exhibit magnetic behavior at the nanscale due to surface and size effects. The experimental observation of these effects is based on the measurement of very small magnetic signals. Thus, some spurious effects that are not critical for bulk materials with large magnetic signals may become important when measuring small signals (typically below 0.0001 emu). Here, we summarize some sources of these small magnetic signals that should be considered when studying this new nanomagnetism, Comment: 16 pages, 10 figures
Published: 2008
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33. Partnering With Patients in a Quality Improvement Curriculum for Internal Medicine Residents

Author: Kramer J Wahlberg MD, Maria Burnett MD, Preetika Muthukrishnan MBBS, MS, Kate Purcell MS, Allen B Repp MD, MSc, Constance van Eeghen DrPh, MHSA, MBA, Elizabeth A Wahlberg MD, and Amanda G Kennedy PharmD, BCPS
Subjects: Medicine (General), R5-920
Abstract: Patient experience is a core component of the Institute for Healthcare Improvement Triple Aim for health care improvement. Although resident physicians must meet quality improvement (QI) competencies prior to graduation, QI training during residency may not adequately prepare residents to improve patient and family experience. We describe an active learning QI curriculum engaging 3 Patient and Family Advisors as partners alongside 15 resident physicians. This partnership proved to be a meaningful experience for both groups, with the development of mutual respect and insight into the contributions that patients and families bring to solving problems in health care quality.
Published: 2021
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34. Arithmetic characteristic classes of automorphic vector bundles

Author: Gil, J. I. Burgos, Kramer, J., and Kuehn, U.
Subjects: Mathematics - Algebraic Geometry, Mathematics - Number Theory, 14G40, 14G35, 14C17, 14C30, 11G18
Abstract: We develop a theory of arithmetic characteristic classes of (fully decomposed) automorphic vector bundles equipped with an invariant hermitian metric. These characteristic classes have values in an arithmetic Chow ring constructed by means of differential forms with certain log-log type singularities. We first study the cohomological properties of log-log differential forms, prove a Poincar\'e lemma for them and construct the corresponding arithmetic Chow groups. Then we introduce the notion of log-singular hermitian vector bundles, which is a variant of the good hermitian vector bundles introduced by Mumford, and we develop the theory of arithmetic characteristic classes. Finally we prove that the hermitian metrics of automorphic vector bundles considered by Mumford are not only good but also log-singular. The theory presented here provides the theoretical background which is required in the formulation of the conjectures of Maillot-Roessler in the semi-abelian case and which is needed to extend Kudla's program about arithmetic intersections on Shimura varieties to the non compact case., Comment: 104 pages
Published: 2005

35. Ballistic resistivity in aluminum nanocontacts

Author: Hasmy, A., Perez-Jimenez, A. J., Palacios, J. J., Garcia-Mochales, P., Costa-Kramer, J. L., Diaz, M., Medina, E., and Serena, P. A.
Subjects: Condensed Matter - Materials Science
Abstract: One of the major industrial challenges is to profit from some fascinating physical features present at the nanoscale. The production of dissipationless nanoswitches (or nanocontacts) is one of such attractive applications. Nevertheless, the lack of knowledge of the real efficiency of electronic ballistic/non dissipative transport limits future innovations. For multi-valent metallic nanosystems -where several transport channels per atom are involved- the only experimental technique available for statistical transport characterization is the conductance histogram. Unfortunately its interpretation is difficult because transport and mechanical properties are intrinsically interlaced. We perform a representative series of semiclassical molecular dynamics simulations of aluminum nanocontact breakages, coupled to full quantum conductance calculations, and put in evidence a linear relationship between the conductance and the contact minimum cross-section for the geometrically favored aluminum nanocontact configurations. Valid in a broad range of conductance values, such relation allows the definition of a transport parameter for nanomaterials, that represents the novel concept of ballistic resistivity.
Published: 2004
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36. Cohomological arithmetic Chow rings

Author: Gil, J. I. Burgos, Kramer, J., and Kuehn, U.
Subjects: Mathematics - Number Theory, Mathematics - Algebraic Geometry, 14G40 14G35 14C17 14C30 11G18
Abstract: We develop a theory of abstract arithmetic Chow rings where the role of the fibers at infinity is played by a complex of abelian groups that computes a suitable cohomology theory. This theory allows the construction of many variants of the arithmetic Chow groups with different properties. As particular cases of this formalism we recover the original arithmetic intersection theory of Gillet and Soul\'e for projective varieties, we introduce a theory of arithmetic Chow groups which are covariant with respect to arbitrary proper morphisms, and we develop a theory of arithmetic Chow rings using a complex of differential forms with log-log singularities along a fixed normal crossings divisor. This last theory is suitable for the study of automorphic line bundles. In particular, we generalize the classical Faltings height with respect to a logarithmically singular hermitian line bundle to higher dimensional cycles. As an application we compute the Faltings height of Hecke correspondences on a product of modular curves., Comment: Minor errors and typos corrected; extended introduction; references added
Published: 2004

37. Dezentrale Arbeitsplätze in der Anästhesiologie

Author: Kramer, J., Malsy, M., Sinner, B., and Graf, B. M.
Published: 2019
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38. ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry

Author: Bierut, LJ, Goate, AM, Breslau, N, Johnson, EO, Bertelsen, S, Fox, L, Agrawal, A, Bucholz, KK, Grucza, R, Hesselbrock, V, Kramer, J, Kuperman, S, Nurnberger, J, Porjesz, B, Saccone, NL, Schuckit, M, Tischfield, J, Wang, JC, Foroud, T, Rice, JP, and Edenberg, HJ
Subjects: Substance Misuse, Alcoholism, Alcohol Use and Health, Brain Disorders, Genetics, Mental health, Good Health and Well Being, Adolescent, Adult, Aged, Alcohol Dehydrogenase, Alcohol Drinking, Alcoholism, Alleles, Black People, Case-Control Studies, Female, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, White People, ADH1B, alcohol dehydrogenase, alcohol dependence, association study, genetics, protective allele, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract: A coding variant in alcohol dehydrogenase 1B (ADH1B) (rs1229984) that leads to the replacement of Arg48 with His48 is common in Asian populations and reduces their risk for alcoholism, but because of very low allele frequencies the effects in European or African populations have been difficult to detect. We genotyped and analyzed this variant in three large European and African-American case-control studies in which alcohol dependence was defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria, and demonstrated a strong protective effect of the His48 variant (odds ratio (OR) 0.34, 95% confidence interval (CI) 0.24, 0.48) on alcohol dependence, with genome-wide significance (6.6 × 10(-10)). The hypothesized mechanism of action involves an increased aversive reaction to alcohol; in keeping with this hypothesis, the same allele is strongly associated with a lower maximum number of drinks in a 24-hour period (lifetime), with P=3 × 10(-13). We also tested the effects of this allele on the development of alcoholism in adolescents and young adults, and demonstrated a significantly protective effect. This variant has the strongest effect on risk for alcohol dependence compared with any other tested variant in European populations.
Published: 2012

39. Metabolite activity in the anterior cingulate cortex during a painful stimulus using functional MRS

Author: Archibald, J., MacMillan, E. L., Graf, C., Kozlowski, P., Laule, C., and Kramer, J. L. K.
Published: 2020
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40. Multimessenger Characterization of Markarian 501 during Historically Low X-Ray and γ-Ray Activity

Author: Abe, H., primary, Abe, S., additional, Acciari, V. A., additional, Agudo, I., additional, Aniello, T., additional, Ansoldi, S., additional, Antonelli, L. A., additional, Arbet-Engels, A., additional, Arcaro, C., additional, Artero, M., additional, Asano, K., additional, Baack, D., additional, Babić, A., additional, Baquero, A., additional, de Almeida, U. Barres, additional, Barrio, J. A., additional, Batković, I., additional, Baxter, J., additional, Becerra González, J., additional, Bednarek, W., additional, Bernardini, E., additional, Bernardos, M., additional, Berti, A., additional, Besenrieder, J., additional, Bhattacharyya, W., additional, Bigongiari, C., additional, Biland, A., additional, Blanch, O., additional, Bonnoli, G., additional, Bošnjak, Ž., additional, Burelli, I., additional, Busetto, G., additional, Carosi, R., additional, Carretero-Castrillo, M., additional, Castro-Tirado, A. J., additional, Ceribella, G., additional, Chai, Y., additional, Chilingarian, A., additional, Cikota, S., additional, Colombo, E., additional, Contreras, J. L., additional, Cortina, J., additional, Covino, S., additional, D’Amico, G., additional, D’Elia, V., additional, Da Vela, P., additional, Dazzi, F., additional, De Angelis, A., additional, De Lotto, B., additional, Del Popolo, A., additional, Delfino, M., additional, Delgado, J., additional, Delgado Mendez, C., additional, Depaoli, D., additional, Di Pierro, F., additional, Di Venere, L., additional, Souto Espiñeira, E. Do, additional, Dominis Prester, D., additional, Donini, A., additional, Dorner, D., additional, Doro, M., additional, Elsaesser, D., additional, Emery, G., additional, Escudero, J., additional, Fallah Ramazani, V., additional, Fariña, L., additional, Fattorini, A., additional, Foffano, L., additional, Font, L., additional, Fruck, C., additional, Fukami, S., additional, Fukazawa, Y., additional, García López, R. J., additional, Garczarczyk, M., additional, Gasparyan, S., additional, Gaug, M., additional, Giesbrecht Paiva, J. G., additional, Giglietto, N., additional, Giordano, F., additional, Gliwny, P., additional, Godinović, N., additional, Grau, R., additional, Green, D., additional, Green, J. G., additional, Hadasch, D., additional, Hahn, A., additional, Hassan, T., additional, Heckmann, L., additional, Herrera, J., additional, Hrupec, D., additional, Hütten, M., additional, Imazawa, R., additional, Inada, T., additional, Iotov, R., additional, Ishio, K., additional, Jiménez Martínez, I., additional, Jormanainen, J., additional, Kerszberg, D., additional, Kobayashi, Y., additional, Kubo, H., additional, Kushida, J., additional, Lamastra, A., additional, Lelas, D., additional, Leone, F., additional, Lindfors, E., additional, Linhoff, L., additional, Lombardi, S., additional, Longo, F., additional, López-Coto, R., additional, López-Moya, M., additional, López-Oramas, A., additional, Loporchio, S., additional, Lorini, A., additional, Lyard, E., additional, Machado de Oliveira Fraga, B., additional, Majumdar, P., additional, Makariev, M., additional, Maneva, G., additional, Mang, N., additional, Manganaro, M., additional, Mangano, S., additional, Mannheim, K., additional, Mariotti, M., additional, Martínez, M., additional, Mas-Aguilar, A., additional, Mazin, D., additional, Menchiari, S., additional, Mender, S., additional, Mićanović, S., additional, Miceli, D., additional, Miener, T., additional, Miranda, J. M., additional, Mirzoyan, R., additional, Molina, E., additional, Mondal, H. A., additional, Moralejo, A., additional, Morcuende, D., additional, Moreno, V., additional, Nakamori, T., additional, Nanci, C., additional, Nava, L., additional, Neustroev, V., additional, Nievas Rosillo, M., additional, Nigro, C., additional, Nilsson, K., additional, Nishijima, K., additional, Njoh Ekoume, T., additional, Noda, K., additional, Nozaki, S., additional, Ohtani, Y., additional, Oka, T., additional, Okumura, A., additional, Otero-Santos, J., additional, Paiano, S., additional, Palatiello, M., additional, Paneque, D., additional, Paoletti, R., additional, Paredes, J. M., additional, Pavletić, L., additional, Persic, M., additional, Pihet, M., additional, Pirola, G., additional, Podobnik, F., additional, Moroni, P. G. Prada, additional, Prandini, E., additional, Principe, G., additional, Priyadarshi, C., additional, Rhode, W., additional, Ribó, M., additional, Rico, J., additional, Righi, C., additional, Rugliancich, A., additional, Sahakyan, N., additional, Saito, T., additional, Sakurai, S., additional, Satalecka, K., additional, Saturni, F. G., additional, Schleicher, B., additional, Schmidt, K., additional, Schmuckermaier, F., additional, Schubert, J. L., additional, Schweizer, T., additional, Sitarek, J., additional, Sliusar, V., additional, Sobczynska, D., additional, Spolon, A., additional, Stamerra, A., additional, Strišković, J., additional, Strom, D., additional, Strzys, M., additional, Suda, Y., additional, Surić, T., additional, Tajima, H., additional, Takahashi, M., additional, Takeishi, R., additional, Tavecchio, F., additional, Temnikov, P., additional, Terauchi, K., additional, Terzić, T., additional, Teshima, M., additional, Tosti, L., additional, Truzzi, S., additional, Tutone, A., additional, Ubach, S., additional, van Scherpenberg, J., additional, Acosta, M. Vazquez, additional, Ventura, S., additional, Verguilov, V., additional, Viale, I., additional, Vigorito, C. F., additional, Vitale, V., additional, Vovk, I., additional, Walter, R., additional, Will, M., additional, Wunderlich, C., additional, Yamamoto, T., additional, Zarić, D., additional, Cerruti, M., additional, Acosta-Pulido, J. A., additional, Apolonio, G., additional, Bachev, R., additional, Baloković, M., additional, Benítez, E., additional, Björklund, I., additional, Bozhilov, V., additional, Brown, L. F., additional, Bugg, A., additional, Carbonell, W., additional, Carnerero, M. I., additional, Carosati, D., additional, Casadio, C., additional, Chamani, W., additional, Chen, W. P., additional, Chigladze, R. A., additional, Damljanovic, G., additional, Epps, K., additional, Erkenov, A., additional, Feige, M., additional, Finke, J., additional, Fuentes, A., additional, Gazeas, K., additional, Giroletti, M., additional, Grishina, T. S., additional, Gupta, A. C., additional, Gurwell,, M. A., additional, Heidemann, E., additional, Hiriart, D., additional, Hou, W. J., additional, Hovatta, T., additional, Ibryamov, S., additional, Joner, M. D., additional, Jorstad, S. G., additional, Kania, J., additional, Kiehlmann, S., additional, Kimeridze, G. N., additional, Kopatskaya, E. N., additional, Kopp, M., additional, Korte, M., additional, Kotas, B., additional, Koyama, S., additional, Kramer, J. A., additional, Kunkel, L., additional, Kurtanidze, S. O., additional, Kurtanidze, O. M., additional, Lähteenmäki, A., additional, López, J. M., additional, Larionov, V. M., additional, Larionova, E. G., additional, Larionova, L. V., additional, Leto, C., additional, Lorey, C., additional, Mújica, R., additional, Madejski, G. M., additional, Marchili, N., additional, Marscher, A. P., additional, Minev, M., additional, Modaressi, A., additional, Morozova, D. A., additional, Mufakharov, T., additional, Myserlis, I., additional, Nikiforova, A. A., additional, Nikolashvili, M. G., additional, Ovcharov, E., additional, Perri, M., additional, Raiteri, C. M., additional, Readhead, A. C. S., additional, Reimer, A., additional, Reinhart, D., additional, Righini, S., additional, Rosenlehner, K., additional, Sadun, A. C., additional, Savchenko, S. S., additional, Scherbantin, A., additional, Schneider, L., additional, Schoch, K., additional, Seifert, D., additional, Semkov, E., additional, Sigua, L. A., additional, Singh, C., additional, Sola, P., additional, Sotnikova, Y., additional, Spencer, M., additional, Steineke, R., additional, Stojanovic, M., additional, Strigachev, A., additional, Tornikoski, M., additional, Traianou, E., additional, Tramacere, A., additional, Troitskaya, Yu. V., additional, Troitskiy, I. S., additional, Trump, J. B., additional, Tsai, A., additional, Valcheva, A., additional, Vasilyev, A. A., additional, Verrecchia, F., additional, Villata, M., additional, Vince, O., additional, Vrontaki, K., additional, Weaver, Z. R., additional, Zaharieva, E., additional, and Zottmann, N., additional
Published: 2023
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41. Free-electron Model for Mesoscopic Force Fluctuations in Nanowires

Author: Blom, S., Olin, H., Costa-Kramer, J. L., Garcia, N., Jonson, M., Serena, P. A., and Shekhter, R. I.
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics
Abstract: When two metal electrodes are separated, a nanometer sized wire (nanowire) is formed just before the contact breaks. The electrical conduction measured during this retraction process shows signs of quantized conductance in units of G_0=2e^2/h. Recent experiments show that the force acting on the wire during separation fluctuates, which has been interpreted as being due to atomic rearrangements. In this report we use a simple free electron model, for two simple geometries, and show that the electronic contribution to the force fluctuations is comparable to the experimentally found values, about 2 nN., Comment: 4 pages, 3 figures, reference corrected
Published: 1997
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42. Repeating flaring activity of the blazar AO 0235+164.

Author: Escudero Pedrosa, J., Agudo, I., Tramacere, A., Marscher, A. P., Jorstad, S., Weaver, Z. R., Casadio, C., Thum, C., Myserlis, I., Fuentes, A., Traianou, E., Kim, J.-Y., Kramer, J., López-Coto, R., D'Ammando, F., Bernardos, M., Bonnoli, G., Blinov, D. A., Borman, G. A., and Grishina, T. S.
Subjects: SPECTRAL energy distribution, STATISTICAL correlation, X-ray spectra, IMAGE analysis
Abstract: Context. Blazar AO 0235+164, located at a redshift of z = 0.94, has undergone several sharp multi-spectral-range flaring episodes over recent decades. In particular, the episodes that peaked in 2008 and 2015, which were subject to extensive multi-wavelength coverage, exhibited an interesting behavior. Aims. We study the actual origin of these two observed flares by constraining the properties of the observed photo-polarimetric variability as well as of the broadband spectral energy distribution and the observed time-evolution behavior of the source. We use ultra-high-resolution total-flux and polarimetric very-long-baseline interferometry (VLBI) imaging. Methods. The analysis of VLBI images allowed us to constrain kinematic and geometrical parameters of the 7 mm jet. We used the discrete correlation function to compute the statistical correlation and the delays between emission at different spectral ranges. The multi-epoch modeling of the spectral energy distributions allowed us to propose specific models of the emission; in particular, with the aim to model the unusual spectral features observed in this source in the X-ray region of the spectrum during strong multi spectral-range flares. Results. We find that these X-ray spectral features can be explained by an emission component originating in a separate particle distribution than the one responsible for the two standard blazar bumps. This is in agreement with the results of our correlation analysis, where we did not find a strong correlation between the X-ray and the remaining spectral ranges. We find that both external Compton-dominated and synchrotron self-Compton-dominated models are able to explain the observed spectral energy distributions. However, the synchrotron self-Compton models are strongly favored by the delays and geometrical parameters inferred from the observations. [ABSTRACT FROM AUTHOR]
Published: 2024
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43. Effects of Continuous Accelerated Pacing on Cardiac Structure and Function in Patients With Heart Failure With Preserved Ejection Fraction: Insights From the myPACE Randomized Clinical Trial.

Author: Wahlberg, Kramer J., Infeld, Margaret, Plante, Timothy B., Novelli, Alexandra E., Habel, Nicole, Burkhoff, Daniel, Barrett, Trace, Lustgarten, Daniel, and Meyer, Markus
Published: 2024
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44. Effect of paced heart rate on quality of life and natriuretic peptides for stage B or C heart failure with preserved ejection fraction: A secondary analysis of the myPACE trial.

Author: de la Espriella, Rafael, Wahlberg, Kramer J., Infeld, Margaret, Palau, Patricia, Núñez, Eduardo, Sanchis, Juan, Meyer, Markus, and Núñez, Julio
Subjects: *BRAIN natriuretic factor, *NATRIURETIC peptides, *HEART beat, *VENTRICULAR ejection fraction, *HEART failure, *HEART failure patients
Abstract: Aim: Emerging evidence suggests a beneficial effect of higher heart rates in some patients with heart failure with preserved ejection fraction (HFpEF). This study aimed to evaluate the impact of higher backup pacing rates in HFpEF patients with preexisting pacemaker systems that limit pacemaker‐mediated dyssynchrony across left ventricular (LV) volumes and LV ejection fraction (LVEF). Methods and results: This is a post‐hoc analysis of the myPACE clinical trial that evaluated the effects of personalized accelerated pacing setting (myPACE) versus standard of care on changes in Minnesota Living with Heart Failure Questionnaire (MLHFQ) score, N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), pacemaker‐detected activity levels, and atrial fibrillation (AF) burden in patients with HFpEF with preexisting pacemakers. Between‐treatment comparisons were performed using linear regression models adjusting for the baseline value of the exposure (ANCOVA design). This study included 93 patients with pre‐trial transthoracic echocardiograms available (usual care n = 49; myPACE n = 44). NT‐proBNP levels and MLHFQ scores improved in a higher magnitude in the myPACE group at lower indexed LV end‐diastolic volumes (iLVEDV) (NT‐proBNP–iLVEDV interaction p = 0.006; MLHFQ–iLVEDV interaction p = 0.068). In addition, personalized accelerated pacing led to improved changes in activity levels and NT‐proBNP, especially at higher LVEF (activity levels–LVEF interaction p = 0.009; NT‐proBNP–LVEF interaction p = 0.058). No evidence of heterogeneity was found across LV volumes or LVEF for pacemaker‐detected AF burden. Conclusions: In the post‐hoc analysis of the myPACE trial, we observed that the benefits of a personalized accelerated backup pacing on MLHFQ score, NT‐proBNP, and pacemaker‐detected activity levels appear to be more pronounced in patients with smaller iLVEDV and higher LVEF. [ABSTRACT FROM AUTHOR]
Published: 2024
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45. Phage Typing of Campylobacter jejuni and Campylobacter coli and Its Use as an Adjunct to Serotyping

Author: Frost, J. A. and Kramer, J. M.
Published: 1999

46. Sixteen years of lead poisoning in eagles, 1980-95: An epizootiologic view

Author: Kramer, J L, Redig, P T, and BioStor
Published: 1997

47. Effect of frailty on 6-month outcome after traumatic brain injury: a multicentre cohort study with external validation

Author: Galimberti, S, Graziano, F, Maas, A, Isernia, G, Lecky, F, Jain, S, Sun, X, Gardner, R, Taylor, S, Markowitz, A, Manley, G, Valsecchi, M, Bellelli, G, Citerio, G, Ackerlund, C, Adams, H, Amrein, K, Andelic, N, Andreassen, L, Anke, A, Antoni, A, Audibert, G, Azouvi, P, Azzolini, M, Bartels, R, Barzo, P, Beauvais, R, Beer, R, Bellander, B, Belli, A, Benali, H, Berardino, M, Beretta, L, Blaabjerg, M, Bragge, P, Brazinova, A, Brinck, V, Brooker, J, Brorsson, C, Buki, A, Bullinger, M, Cabeleira, M, Caccioppola, A, Calappi, E, Calvi, M, Cameron, P, Carbayo Lozano, G, Carbonara, M, Castano-Leon, A, Cavallo, S, Chevallard, G, Chieregato, A, Clusmann, H, Coburn, M, Coles, J, Cooper, J, Correia, M, Covic, A, Curry, N, Czeiter, E, Czosnyka, M, Dahyot-Fizelier, C, Dark, P, Dawes, H, De Keyser, V, Degos, V, Della Corte, F, den Boogert, H, Depreitere, B, Dilvesi, D, Dixit, A, Donoghue, E, Dreier, J, Duliere, G, Ercole, A, Esser, P, Ezer, E, Fabricius, M, Feigin, V, Foks, K, Frisvold, S, Furmanov, A, Gagliardo, P, Galanaud, D, Gantner, D, Gao, G, George, P, Ghuysen, A, Giga, L, Glocker, B, Golubovic, J, Gomez, P, Gratz, J, Gravesteijn, B, Grossi, F, Gruen, R, Gupta, D, Haagsma, J, Haitsma, I, Helbok, R, Helseth, E, Horton, L, Huijben, J, Hutchinson, P, Jacobs, B, Jankowski, S, Jarrett, M, Jiang, J, Johnson, F, Jones, K, Karan, M, Kolias, A, Kompanje, E, Kondziella, D, Koskinen, L, Kovacs, N, Kowark, A, Lagares, A, Lanyon, L, Laureys, S, Ledoux, D, Lefering, R, Legrand, V, Lejeune, A, Levi, L, Lightfoot, R, Lingsma, H, Maegele, M, Majdan, M, Manara, A, Marechal, H, Martino, C, Mattern, J, Mcfadyen, C, Mcmahon, C, Melegh, B, Menon, D, Menovsky, T, Mikolic, A, Misset, B, Muraleedharan, V, Murray, L, Negru, A, Nelson, D, Newcombe, V, Nieboer, D, Nyiradi, J, Oresic, M, Ortolano, F, Otesile, O, Palotie, A, Parizel, P, Payen, J, Perera, N, Perlbarg, V, Persona, P, Peul, W, Piippo-Karjalainen, A, Pirinen, M, Pisica, D, Ples, H, Polinder, S, Pomposo, I, Posti, J, Puybasset, L, Radoi, A, Ragauskas, A, Raj, R, Rambadagalla, M, Rehorcikova, V, Retel Helmrich, I, Rhodes, J, Richardson, S, Richter, S, Ripatti, S, Rocka, S, Roe, C, Roise, O, Rosenfeld, J, Rosenlund, C, Rosenthal, G, Rossaint, R, Rossi, S, Rueckert, D, Rusnak, M, Sahuquillo, J, Sakowitz, O, Sanchez-Porras, R, Sandor, J, Schafer, N, Schmidt, S, Schoechl, H, Schoonman, G, Schou, R, Schwendenwein, E, Sewalt, C, Singh, R, Skandsen, T, Smielewski, P, Sorinola, A, Stamatakis, E, Stanworth, S, Stevens, R, Stewart, W, Steyerberg, E, Stocchetti, N, Sundstrom, N, Takala, R, Tamas, V, Tamosuitis, T, Taylor, M, Te Ao, B, Tenovuo, O, Theadom, A, Thomas, M, Tibboel, D, Timmers, M, Tolias, C, Trapani, T, Tudora, C, Unterberg, A, Vajkoczy, P, Valeinis, E, Vallance, S, Vamos, Z, van der Jagt, M, van der Naalt, J, Van der Steen, G, van Dijck, J, van Erp, I, van Essen, T, Van Hecke, W, van Heugten, C, Van Praag, D, van Veen, E, van Wijk, R, Vande Vyvere, T, Vargiolu, A, Vega, E, Velt, K, Verheyden, J, Vespa, P, Vik, A, Vilcinis, R, Volovici, V, von Steinbuchel, N, Voormolen, D, Vulekovic, P, Wang, K, Wiegers, E, Williams, G, Wilson, L, Wolf, S, Yang, Z, Ylen, P, Younsi, A, Zeiler, F, Ziverte, A, Zoerle, T, Adeoye, O, Badjatia, N, Barber, J, Bergin, M, Boase, K, Bodien, Y, Chesnut, R, Corrigan, J, Crawford, K, Diaz-Arrastia, R, Dikmen, S, Duhaime, A, Ellenbogen, R, Feeser, V, Ferguson, A, Foreman, B, Gaudette, E, Giacino, J, Gonzalez, L, Gopinath, S, Grandhi, R, Gullapalli, R, Hemphill, C, Hotz, G, Huie, R, Jha, R, Keene, C, Kitagawa, R, Korley, F, Kramer, J, Kreitzer, N, Levin, H, Lindsell, C, Machamer, J, Madden, C, Martin, A, Mcallister, T, Mccrea, M, Merchant, R, Mukherjee, P, Nelson, L, Ngwenya, L, Noel, F, Nolan, A, Okonkwo, D, Palacios, E, Perl, D, Puccio, A, Rabinowitz, M, Robertson, C, Rodgers, R, Rosand, J, Rosenthal, E, Sander, A, Sandsmark, D, Sugar, G, Schneider, A, Schnyer, D, Seabury, S, Sherer, M, Stein, M, Temkin, N, Toga, A, Torres-Espin, A, Valadka, A, Vassar, M, Wang, V, Yue, J, Yuh, E, Zafonte, R, Galimberti S., Graziano F., Maas A. I. R., Isernia G., Lecky F., Jain S., Sun X., Gardner R. C., Taylor S. R., Markowitz A. J., Manley G. T., Valsecchi M. G., Bellelli G., Citerio G., Ackerlund C., Adams H., Amrein K., Andelic N., Andreassen L., Anke A., Antoni A., Audibert G., Azouvi P., Azzolini M. L., Bartels R., Barzo P., Beauvais R., Beer R., Bellander B. -M., Belli A., Benali H., Berardino M., Beretta L., Blaabjerg M., Bragge P., Brazinova A., Brinck V., Brooker J., Brorsson C., Buki A., Bullinger M., Cabeleira M., Caccioppola A., Calappi E., Calvi M. R., Cameron P., Carbayo Lozano G., Carbonara M., Castano-Leon A. M., Cavallo S., Chevallard G., Chieregato A., Clusmann H., Coburn M. S., Coles J., Cooper J. D., Correia M., Covic A., Curry N., Czeiter E., Czosnyka M., Dahyot-Fizelier C., Dark P., Dawes H., De Keyser V., Degos V., Della Corte F., den Boogert H., Depreitere B., Dilvesi D., Dixit A., Donoghue E., Dreier J., Duliere G. -L., Ercole A., Esser P., Ezer E., Fabricius M., Feigin V. L., Foks K., Frisvold S., Furmanov A., Gagliardo P., Galanaud D., Gantner D., Gao G., George P., Ghuysen A., Giga L., Glocker B., Golubovic J., Gomez P. A., Gratz J., Gravesteijn B., Grossi F., Gruen R. L., Gupta D., Haagsma J. A., Haitsma I., Helbok R., Helseth E., Horton L., Huijben J., Hutchinson P. J., Jacobs B., Jankowski S., Jarrett M., Jiang J. -Y., Johnson F., Jones K., Karan M., Kolias A. G., Kompanje E., Kondziella D., Koskinen L. -O., Kovacs N., Kowark A., Lagares A., Lanyon L., Laureys S., Ledoux D., Lefering R., Legrand V., Lejeune A., Levi L., Lightfoot R., Lingsma H., Maegele M., Majdan M., Manara A., Marechal H., Martino C., Mattern J., McFadyen C., McMahon C., Melegh B., Menon D., Menovsky T., Mikolic A., Misset B., Muraleedharan V., Murray L., Negru A., Nelson D., Newcombe V., Nieboer D., Nyiradi J., Oresic M., Ortolano F., Otesile O., Palotie A., Parizel P. M., Payen J. -F., Perera N., Perlbarg V., Persona P., Peul W., Piippo-Karjalainen A., Pirinen M., Pisica D., Ples H., Polinder S., Pomposo I., Posti J. P., Puybasset L., Radoi A., Ragauskas A., Raj R., Rambadagalla M., Rehorcikova V., Retel Helmrich I., Rhodes J., Richardson S., Richter S., Ripatti S., Rocka S., Roe C., Roise O., Rosenfeld J., Rosenlund C., Rosenthal G., Rossaint R., Rossi S., Rueckert D., Rusnak M., Sahuquillo J., Sakowitz O., Sanchez-Porras R., Sandor J., Schafer N., Schmidt S., Schoechl H., Schoonman G., Schou R. F., Schwendenwein E., Sewalt C., Singh R. D., Skandsen T., Smielewski P., Sorinola A., Stamatakis E., Stanworth S., Stevens R., Stewart W., Steyerberg E. W., Stocchetti N., Sundstrom N., Takala R., Tamas V., Tamosuitis T., Taylor M. S., Te Ao B., Tenovuo O., Theadom A., Thomas M., Tibboel D., Timmers M., Tolias C., Trapani T., Tudora C. M., Unterberg A., Vajkoczy P., Valeinis E., Vallance S., Vamos Z., van der Jagt M., van der Naalt J., Van der Steen G., van Dijck J. T. J. M., van Erp I. A., van Essen T. A., Van Hecke W., van Heugten C., Van Praag D., van Veen E., van Wijk R., Vande Vyvere T., Vargiolu A., Vega E., Velt K., Verheyden J., Vespa P. M., Vik A., Vilcinis R., Volovici V., von Steinbuchel N., Voormolen D., Vulekovic P., Wang K. K. W., Wiegers E., Williams G., Wilson L., Wolf S., Yang Z., Ylen P., Younsi A., Zeiler F. A., Ziverte A., Zoerle T., Adeoye O., Badjatia N., Barber J., Bergin M., Boase K., Bodien Y., Chesnut R., Corrigan J., Crawford K., Diaz-Arrastia R., Dikmen S., Duhaime A. -C., Ellenbogen R., Feeser V., Ferguson A. R., Foreman B., Gaudette E., Giacino J., Gonzalez L., Gopinath S., Grandhi R., Gullapalli R., Hemphill C., Hotz G., Huie R., Jha R., Keene C. D., Kitagawa R., Korley F., Kramer J., Kreitzer N., Levin H., Lindsell C., Machamer J., Madden C., Martin A., McAllister T., McCrea M., Merchant R., Mukherjee P., Nelson L., Ngwenya L. B., Noel F., Nolan A., Okonkwo D., Palacios E., Perl D., Puccio A., Rabinowitz M., Robertson C., Rodgers R. B., Rosand J., Rosenthal E., Sander A., Sandsmark D., Sugar G., Schneider A., Schnyer D., Seabury S., Sherer M., Stein M., Temkin N., Toga A., Torres-Espin A., Valadka A., Vassar M., Wang K., Wang V., Yue J. K., Yuh E., Zafonte R., Galimberti, S, Graziano, F, Maas, A, Isernia, G, Lecky, F, Jain, S, Sun, X, Gardner, R, Taylor, S, Markowitz, A, Manley, G, Valsecchi, M, Bellelli, G, Citerio, G, Ackerlund, C, Adams, H, Amrein, K, Andelic, N, Andreassen, L, Anke, A, Antoni, A, Audibert, G, Azouvi, P, Azzolini, M, Bartels, R, Barzo, P, Beauvais, R, Beer, R, Bellander, B, Belli, A, Benali, H, Berardino, M, Beretta, L, Blaabjerg, M, Bragge, P, Brazinova, A, Brinck, V, Brooker, J, Brorsson, C, Buki, A, Bullinger, M, Cabeleira, M, Caccioppola, A, Calappi, E, Calvi, M, Cameron, P, Carbayo Lozano, G, Carbonara, M, Castano-Leon, A, Cavallo, S, Chevallard, G, Chieregato, A, Clusmann, H, Coburn, M, Coles, J, Cooper, J, Correia, M, Covic, A, Curry, N, Czeiter, E, Czosnyka, M, Dahyot-Fizelier, C, Dark, P, Dawes, H, De Keyser, V, Degos, V, Della Corte, F, den Boogert, H, Depreitere, B, Dilvesi, D, Dixit, A, Donoghue, E, Dreier, J, Duliere, G, Ercole, A, Esser, P, Ezer, E, Fabricius, M, Feigin, V, Foks, K, Frisvold, S, Furmanov, A, Gagliardo, P, Galanaud, D, Gantner, D, Gao, G, George, P, Ghuysen, A, Giga, L, Glocker, B, Golubovic, J, Gomez, P, Gratz, J, Gravesteijn, B, Grossi, F, Gruen, R, Gupta, D, Haagsma, J, Haitsma, I, Helbok, R, Helseth, E, Horton, L, Huijben, J, Hutchinson, P, Jacobs, B, Jankowski, S, Jarrett, M, Jiang, J, Johnson, F, Jones, K, Karan, M, Kolias, A, Kompanje, E, Kondziella, D, Koskinen, L, Kovacs, N, Kowark, A, Lagares, A, Lanyon, L, Laureys, S, Ledoux, D, Lefering, R, Legrand, V, Lejeune, A, Levi, L, Lightfoot, R, Lingsma, H, Maegele, M, Majdan, M, Manara, A, Marechal, H, Martino, C, Mattern, J, Mcfadyen, C, Mcmahon, C, Melegh, B, Menon, D, Menovsky, T, Mikolic, A, Misset, B, Muraleedharan, V, Murray, L, Negru, A, Nelson, D, Newcombe, V, Nieboer, D, Nyiradi, J, Oresic, M, Ortolano, F, Otesile, O, Palotie, A, Parizel, P, Payen, J, Perera, N, Perlbarg, V, Persona, P, Peul, W, Piippo-Karjalainen, A, Pirinen, M, Pisica, D, Ples, H, Polinder, S, Pomposo, I, Posti, J, Puybasset, L, Radoi, A, Ragauskas, A, Raj, R, Rambadagalla, M, Rehorcikova, V, Retel Helmrich, I, Rhodes, J, Richardson, S, Richter, S, Ripatti, S, Rocka, S, Roe, C, Roise, O, Rosenfeld, J, Rosenlund, C, Rosenthal, G, Rossaint, R, Rossi, S, Rueckert, D, Rusnak, M, Sahuquillo, J, Sakowitz, O, Sanchez-Porras, R, Sandor, J, Schafer, N, Schmidt, S, Schoechl, H, Schoonman, G, Schou, R, Schwendenwein, E, Sewalt, C, Singh, R, Skandsen, T, Smielewski, P, Sorinola, A, Stamatakis, E, Stanworth, S, Stevens, R, Stewart, W, Steyerberg, E, Stocchetti, N, Sundstrom, N, Takala, R, Tamas, V, Tamosuitis, T, Taylor, M, Te Ao, B, Tenovuo, O, Theadom, A, Thomas, M, Tibboel, D, Timmers, M, Tolias, C, Trapani, T, Tudora, C, Unterberg, A, Vajkoczy, P, Valeinis, E, Vallance, S, Vamos, Z, van der Jagt, M, van der Naalt, J, Van der Steen, G, van Dijck, J, van Erp, I, van Essen, T, Van Hecke, W, van Heugten, C, Van Praag, D, van Veen, E, van Wijk, R, Vande Vyvere, T, Vargiolu, A, Vega, E, Velt, K, Verheyden, J, Vespa, P, Vik, A, Vilcinis, R, Volovici, V, von Steinbuchel, N, Voormolen, D, Vulekovic, P, Wang, K, Wiegers, E, Williams, G, Wilson, L, Wolf, S, Yang, Z, Ylen, P, Younsi, A, Zeiler, F, Ziverte, A, Zoerle, T, Adeoye, O, Badjatia, N, Barber, J, Bergin, M, Boase, K, Bodien, Y, Chesnut, R, Corrigan, J, Crawford, K, Diaz-Arrastia, R, Dikmen, S, Duhaime, A, Ellenbogen, R, Feeser, V, Ferguson, A, Foreman, B, Gaudette, E, Giacino, J, Gonzalez, L, Gopinath, S, Grandhi, R, Gullapalli, R, Hemphill, C, Hotz, G, Huie, R, Jha, R, Keene, C, Kitagawa, R, Korley, F, Kramer, J, Kreitzer, N, Levin, H, Lindsell, C, Machamer, J, Madden, C, Martin, A, Mcallister, T, Mccrea, M, Merchant, R, Mukherjee, P, Nelson, L, Ngwenya, L, Noel, F, Nolan, A, Okonkwo, D, Palacios, E, Perl, D, Puccio, A, Rabinowitz, M, Robertson, C, Rodgers, R, Rosand, J, Rosenthal, E, Sander, A, Sandsmark, D, Sugar, G, Schneider, A, Schnyer, D, Seabury, S, Sherer, M, Stein, M, Temkin, N, Toga, A, Torres-Espin, A, Valadka, A, Vassar, M, Wang, V, Yue, J, Yuh, E, Zafonte, R, Galimberti S., Graziano F., Maas A. I. R., Isernia G., Lecky F., Jain S., Sun X., Gardner R. C., Taylor S. R., Markowitz A. J., Manley G. T., Valsecchi M. G., Bellelli G., Citerio G., Ackerlund C., Adams H., Amrein K., Andelic N., Andreassen L., Anke A., Antoni A., Audibert G., Azouvi P., Azzolini M. L., Bartels R., Barzo P., Beauvais R., Beer R., Bellander B. -M., Belli A., Benali H., Berardino M., Beretta L., Blaabjerg M., Bragge P., Brazinova A., Brinck V., Brooker J., Brorsson C., Buki A., Bullinger M., Cabeleira M., Caccioppola A., Calappi E., Calvi M. R., Cameron P., Carbayo Lozano G., Carbonara M., Castano-Leon A. M., Cavallo S., Chevallard G., Chieregato A., Clusmann H., Coburn M. S., Coles J., Cooper J. D., Correia M., Covic A., Curry N., Czeiter E., Czosnyka M., Dahyot-Fizelier C., Dark P., Dawes H., De Keyser V., Degos V., Della Corte F., den Boogert H., Depreitere B., Dilvesi D., Dixit A., Donoghue E., Dreier J., Duliere G. -L., Ercole A., Esser P., Ezer E., Fabricius M., Feigin V. L., Foks K., Frisvold S., Furmanov A., Gagliardo P., Galanaud D., Gantner D., Gao G., George P., Ghuysen A., Giga L., Glocker B., Golubovic J., Gomez P. A., Gratz J., Gravesteijn B., Grossi F., Gruen R. L., Gupta D., Haagsma J. A., Haitsma I., Helbok R., Helseth E., Horton L., Huijben J., Hutchinson P. J., Jacobs B., Jankowski S., Jarrett M., Jiang J. -Y., Johnson F., Jones K., Karan M., Kolias A. G., Kompanje E., Kondziella D., Koskinen L. -O., Kovacs N., Kowark A., Lagares A., Lanyon L., Laureys S., Ledoux D., Lefering R., Legrand V., Lejeune A., Levi L., Lightfoot R., Lingsma H., Maegele M., Majdan M., Manara A., Marechal H., Martino C., Mattern J., McFadyen C., McMahon C., Melegh B., Menon D., Menovsky T., Mikolic A., Misset B., Muraleedharan V., Murray L., Negru A., Nelson D., Newcombe V., Nieboer D., Nyiradi J., Oresic M., Ortolano F., Otesile O., Palotie A., Parizel P. M., Payen J. -F., Perera N., Perlbarg V., Persona P., Peul W., Piippo-Karjalainen A., Pirinen M., Pisica D., Ples H., Polinder S., Pomposo I., Posti J. P., Puybasset L., Radoi A., Ragauskas A., Raj R., Rambadagalla M., Rehorcikova V., Retel Helmrich I., Rhodes J., Richardson S., Richter S., Ripatti S., Rocka S., Roe C., Roise O., Rosenfeld J., Rosenlund C., Rosenthal G., Rossaint R., Rossi S., Rueckert D., Rusnak M., Sahuquillo J., Sakowitz O., Sanchez-Porras R., Sandor J., Schafer N., Schmidt S., Schoechl H., Schoonman G., Schou R. F., Schwendenwein E., Sewalt C., Singh R. D., Skandsen T., Smielewski P., Sorinola A., Stamatakis E., Stanworth S., Stevens R., Stewart W., Steyerberg E. W., Stocchetti N., Sundstrom N., Takala R., Tamas V., Tamosuitis T., Taylor M. S., Te Ao B., Tenovuo O., Theadom A., Thomas M., Tibboel D., Timmers M., Tolias C., Trapani T., Tudora C. M., Unterberg A., Vajkoczy P., Valeinis E., Vallance S., Vamos Z., van der Jagt M., van der Naalt J., Van der Steen G., van Dijck J. T. J. M., van Erp I. A., van Essen T. A., Van Hecke W., van Heugten C., Van Praag D., van Veen E., van Wijk R., Vande Vyvere T., Vargiolu A., Vega E., Velt K., Verheyden J., Vespa P. M., Vik A., Vilcinis R., Volovici V., von Steinbuchel N., Voormolen D., Vulekovic P., Wang K. K. W., Wiegers E., Williams G., Wilson L., Wolf S., Yang Z., Ylen P., Younsi A., Zeiler F. A., Ziverte A., Zoerle T., Adeoye O., Badjatia N., Barber J., Bergin M., Boase K., Bodien Y., Chesnut R., Corrigan J., Crawford K., Diaz-Arrastia R., Dikmen S., Duhaime A. -C., Ellenbogen R., Feeser V., Ferguson A. R., Foreman B., Gaudette E., Giacino J., Gonzalez L., Gopinath S., Grandhi R., Gullapalli R., Hemphill C., Hotz G., Huie R., Jha R., Keene C. D., Kitagawa R., Korley F., Kramer J., Kreitzer N., Levin H., Lindsell C., Machamer J., Madden C., Martin A., McAllister T., McCrea M., Merchant R., Mukherjee P., Nelson L., Ngwenya L. B., Noel F., Nolan A., Okonkwo D., Palacios E., Perl D., Puccio A., Rabinowitz M., Robertson C., Rodgers R. B., Rosand J., Rosenthal E., Sander A., Sandsmark D., Sugar G., Schneider A., Schnyer D., Seabury S., Sherer M., Stein M., Temkin N., Toga A., Torres-Espin A., Valadka A., Vassar M., Wang K., Wang V., Yue J. K., Yuh E., and Zafonte R.
Abstract: Background: Frailty is known to be associated with poorer outcomes in individuals admitted to hospital for medical conditions requiring intensive care. However, little evidence is available for the effect of frailty on patients’ outcomes after traumatic brain injury. Many frailty indices have been validated for clinical practice and show good performance to predict clinical outcomes. However, each is specific to a particular clinical context. We aimed to develop a frailty index to predict 6-month outcomes in patients after a traumatic brain injury. Methods: A cumulative deficit approach was used to create a novel frailty index based on 30 items dealing with disease states, current medications, and laboratory values derived from data available from CENTER-TBI, a prospective, longitudinal observational study of patients with traumatic brain injury presenting within 24 h of injury and admitted to a ward or an intensive care unit at 65 centres in Europe between Dec 19, 2014, and Dec 17, 2017. From the individual cumulative CENTER-TBI frailty index (range 0–30), we obtained a standardised value (range 0–1), with high scores indicating higher levels of frailty. The effect of frailty on 6-month outcome evaluated with the extended Glasgow Outcome Scale (GOSE) was assessed through a proportional odds logistic model adjusted for known outcome predictors. An unfavourable outcome was defined as death or severe disability (GOSE score ≤4). External validation was performed on data from TRACK-TBI, a prospective observational study co-designed with CENTER-TBI, which enrolled patients with traumatic brain injury at 18 level I trauma centres in the USA from Feb 26, 2014, to July 27, 2018. CENTER-TBI is registered with ClinicalTrials.gov, NCT02210221; TRACK-TBI is registered at ClinicalTrials.gov, NCT02119182. Findings: 2993 participants (median age was 51 years [IQR 30–67], 2058 [69%] were men) were included in this analysis. The overall median CENTER-TBI frailty index score was 0·07
Published: 2022

48. Förderung der Work-Life-Balance-Kultur – Ein Thema der Betrieblichen Gesundheitsförderung am Beispiel einer High-Tech-Industrie

Author: Nitzsche, A., Kramer, J., Badura, Bernhard, editor, Ducki, Antje, editor, Schröder, Helmut, editor, Klose, Joachim, editor, and Meyer, Markus, editor
Published: 2015
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49. Comparisons of clinically based outcome measures and laboratory-based outcome measure for balance in patients following total hip and knee arthroplasty

Author: Jogi P, Overend TJ, and Kramer J
Subjects: total knee arthroplasty, total hip arthroplasty, force plate, clinical measures, balance, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935
Abstract: Pankaj Jogi, Tom Overend, John Kramer School of Physical Therapy, University of Western Ontario, London, ON, Canada Background: Information available in the literature on clinically based and laboratory-based outcome measures of balance is limited. How much information is provided by clinically based outcome measures compared to laboratory-based measure in patients with total hip (THA) and knee arthroplasty (TKA) is not known. Aim: The purpose of this study was to determine the relationship between selected clinically based outcome measures and laboratory-based force platform measure in patients following THA and TKA. Methods: Patients who underwent THA (n = 26) and TKA (n = 28) were evaluated at about 5–7 weeks following surgery. Participants were assessed using four clinically based outcome measures – 1) the Berg Balance Scale (BBS), 2) the Timed Up and Go test (TUG), 3) the Activities-specific Balance Confidence Scale (ABC), and 4) the Western Ontario McMaster Universities Osteoarthritis Index-function subscale (WOMAC-function) – and one laboratory-based force plate measure (95% ellipse area). Results: Moderate correlations were observed between the BBS and the 95% ellipse area of force plate (r = 0.46–0.51) for the two-legged stance, the anterior lean stance, and the posterior lean stance. Fair correlations were observed between TUG and the 95% ellipse area of force plate (r = 0.31–0.37) for all the three test conditions. Low correlations were observed for the ABC and the WOMAC-function with the 95% ellipse area of force plate (r = 0.11–0.25) for all the three test conditions. Conclusion: The BBS demonstrated the greatest correlations with the 95% ellipse area of the force plate measure and should be preferred by physical therapists over the TUG, the ABC, and the WOMAC-function to assess balance in patients with THA and TKA. Keywords: total knee arthroplasty, total hip arthroplasty, force plate, clinical measures, balance
Published: 2017

50. An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry

Author: Meyers, J L, Zhang, J, Wang, J C, Su, J, Kuo, S I, Kapoor, M, Wetherill, L, Bertelsen, S, Lai, D, Salvatore, J E, Kamarajan, C, Chorlian, D, Agrawal, A, Almasy, L, Bauer, L, Bucholz, K K, Chan, G, Hesselbrock, V, Koganti, L, Kramer, J, Kuperman, S, Manz, N, Pandey, A, Seay, M, Scott, D, Taylor, R E, Dick, D M, Edenberg, H J, Goate, A, Foroud, T, and Porjesz, B
Published: 2017
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