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27 results on '"Kraev, Krasimir"'

3. Descending Necrotizing Mediastinitis in Healthy Young Adults: The Fatal Consequence of the Delayed Help

Author

Uchikov, Petar, primary, Kraeva, Maria, additional, Kraev, Krasimir, additional, Hristov, Bozhidar, additional, Chakarov, Dzhevdet, additional, Ali, Nedzhat, additional, Stefanov, Chavdar, additional, Mollova-Kyosebekirova, Angelina, additional, Tenchev, Tihomir, additional, Dragusheva, Snezhanka, additional, Dzhambazova, Elizabet, additional, and Dobreva-Yatseva, Bistra, additional

Published
2024
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5. Prognostic models of drug-induced neutralizing antibody formation in patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis treated with TNF-α blockersockers

Author

Kraev, Krasimir, primary, Hristov, Bozhidar, additional, Uchikov, Petar, additional, Kraeva, Mariya, additional, Geneva-Popova, Mariela, additional, Popova, Stanislava, additional, Basheva-Kraeva, Yordanka, additional, Stoyanova, Nina S., additional, and Mitkova-Hristova, Vesela, additional

Published
2024
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8. Rare case of enteric type of urachal adenocarcinoma: A case report

Author

Uchikov, Petar, primary, Ali, Nedzhat, additional, Kraev, Krasimir, additional, Hristov, Bozhidar, additional, Ivanov, Atanas, additional, Doykov, Mladen, additional, Koleva-Ivanova, Maria, additional, Mollova-Kyosebekirova, Angelina, additional, Kraeva, Maria, additional, Chakarov, Dzhevdet, additional, Sandeva, Milena, additional, Dobreva-Yatseva, Bistra, additional, and Antonov, Petar, additional

Published
2024
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10. Comprehensive Exploration of Antinuclear Antibodies (ANAs): Unveiling Clinical Significance, Associations with Cancer, and the Nuances of Differential Diagnosis in Positive ANA Patients

Author

Kraev, Krasimir, primary, Hristov, Bozhidar, additional, Uchikov, Petar, additional, Kraeva, Maria, additional, Basheva-Kraeva, Yordanka, additional, Valova, Siyana, additional, Koleva-Ivanova, Maria, additional, Popova-Belova, Stanislava, additional, Sandeva, Milena, additional, Chakarov, Dzhevdet, additional, and Geneva-Popova, Mariela, additional

Published
2024
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13. Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition.

Author

Todorova, Velislava, Ivanova, Stanislava, Chakarov, Dzhevdet, Kraev, Krasimir, and Ivanov, Kalin

Abstract

The naturally occurring compounds ecdysterone and turkesterone, which are present in plants, including Rhaponticum carthamoides Willd. (Iljin), Spinacia oleracea L., Chenopodium quinoa Willd., and Ajuga turkestanica (Regel) Briq, are widely recognized due to their possible advantages for both general health and athletic performance. The current review investigates the beneficial biological effects of ecdysterone and turkesterone in nutrition, highlighting their roles not only in enhancing athletic performance but also in the management of various health problems. Plant-based diets, associated with various health benefits and environmental sustainability, often include sources rich in phytoecdysteroids. However, the therapeutic potential of phytoecdysteroid-rich extracts extends beyond sports nutrition, with promising applications in treating chronic fatigue, cardiovascular diseases, and neurodegenerative disorders. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Coexistence of ankylosing spondylitis and Behçet's disease: Successful treatment with upadacitinib.

Author

Kraev, Krasimir, Uchikov, Petar, Hristov, Bozhidar, Kraeva, Maria, Basheva‐Kraeva, Yordanka, Popova‐Belova, Stanislava, Sandeva, Milena, Chakarov, Dzhevdet, Dragusheva, Snezhanka, and Geneva‐Popova, Mariela

Subjects
*BEHCET'S disease, *THERAPEUTICS, *TREATMENT effectiveness, *LUMBAR pain, *HEARING disorders, *ANKYLOSING spondylitis
Abstract

Background: Ankylosing spondylitis (AS) and Behçet's disease (BD) are distinct inflammatory disorders, but their coexistence is a rare clinical entity. This case sheds light on managing this complex scenario with Janus kinase (JAK) inhibitors. Case Presentation: A 42‐year‐old woman presented with a decade‐long history of lower back pain, nocturnal spinal discomfort, recurrent eye issues, oral and genital ulcers, hearing loss, pus formation in the left eye, and abdominal pain. Multidisciplinary consultations and diagnostic tests confirmed AS (HLA‐B27 positivity and sacroiliitis) and BD (HLA‐B51). Elevated acute‐phase markers were observed. Conclusion: This case fulfills diagnostic criteria for both AS and BD, emphasizing their coexistence. Notably, treatment with upadacitinib exhibited promising efficacy, underscoring its potential as a therapeutic option in patients with contraindications for conventional treatments. Our findings illuminate the intricate management of patients presenting with these two diverse systemic conditions and advocate for further exploration of JAK inhibitors in similar cases. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Examining the Safety Profile of Janus Kinase (JAK) Inhibitors in the Management of Immune-Mediated Diseases: A Comprehensive Review

Author

Kraev, Krasimir, primary, Geneva-Popova, Mariela Gencheva, additional, Hristov, Bozhidar Krasimirov, additional, Uchikov, Petar Angelov, additional, Belova-Popova, Stanislava Dimitrova, additional, Kraeva, Maria Ilieva, additional, Basheva-Kraeva, Yordanka Mincheva, additional, Stoyanova, Nina Staneva, additional, Mitkova-Hristova, Vesela Todorova, additional, Koleva-Ivanova, Maria Stoyanova, additional, Taneva, Daniela Ivova, additional, and Ivanov, Atanas Slavchev, additional

Published
2023
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18. Celebrating Versatility: Febuxostat’s Multifaceted Therapeutic Application

Author

Kraev, Krasimir Iliev, primary, Geneva-Popova, Mariela Gencheva, additional, Hristov, Bozhidar Krasimirov, additional, Uchikov, Petar Angelov, additional, Popova-Belova, Stanislava Dimitrova, additional, Kraeva, Maria Ilieva, additional, Basheva-Kraeva, Yordanka Mincheva, additional, Stoyanova, Nina Staneva, additional, and Mitkova-Hristova, Vesela Todorova, additional

Published
2023
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20. Surgical Innovations in Tracheal Reconstruction: A Review on Synthetic Material Fabrication.

Author

Khalid, Usman, Uchikov, Petar, Hristov, Bozhidar, Kraev, Krasimir, Koleva-Ivanova, Maria, Kraeva, Maria, Batashki, Atanas, Taneva, Daniela, Doykov, Mladen, and Uchikov, Angel

Subjects
THREE-dimensional printing, STEM cell treatment, HUMAN body, DATABASES, RESEARCH personnel, STEM cell transplantation
Abstract

Background and Objectives: The aim of this review is to explore the recent surgical innovations in tracheal reconstruction by evaluating the uses of synthetic material fabrication when dealing with tracheomalacia or stenotic pathologies, then discussing the challenges holding back these innovations. Materials and Methods: A targeted non-systematic review of published literature relating to tracheal reconstruction was performed within the PubMed database to help identify how synthetic materials are utilised to innovate tracheal reconstruction. Results: The advancements in 3D printing to aid synthetic material fabrication have unveiled promising alternatives to conventional approaches. Achieving successful tracheal reconstruction through this technology demands that the 3D models exhibit biocompatibility with neighbouring tracheal elements by encompassing vasculature, chondral foundation, and immunocompatibility. Tracheal reconstruction has employed grafts and scaffolds, showing a promising beginning in vivo. Concurrently, the integration of resorbable models and stem cell therapy serves to underscore their viability and application in the context of tracheal pathologies. Despite this, certain barriers hinder its advancement in surgery. The intricate tracheal structure has posed a challenge for researchers seeking novel approaches to support its growth and regeneration. Conclusions: The potential of synthetic material fabrication has shown promising outcomes in initial studies involving smaller animals. Yet, to fully realise the applicability of these innovative developments, research must progress toward clinical trials. These trials would ascertain the anatomical and physiological effects on the human body, enabling a thorough evaluation of post-operative outcomes and any potential complications linked to the materials or cells implanted in the trachea. [ABSTRACT FROM AUTHOR]

Published
2024
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