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828 results on '"Kraemer, D."'

3. New Physics at the International Facility for Antiproton and Ion Research (FAIR) Next to GSI

Author

Augustin, I., Gutbrod, H. H., Kraemer, D., Langanke, K., and Stoecker, H.

Subjects
High Energy Physics - Phenomenology, Nuclear Experiment
Abstract

The project of the international Facility for Antiproton and Ion Research (FAIR), co-located to the GSI facility in Darmstadt, has been officially started on November 7, 2007. The current plans of the facility and the planned research program will be described. An investment of about 1 billion euro will permit new physics programs in the areas of low and medium energy antiproton research, heavy ion physics complementary to LHC, as well as in nuclear structure and astrophysics. The facility will comprise about a dozen accelerators and storage rings, which will enable simultaneous operations of up to four different beams., Comment: 7 pages, 1 figure. Invited Talk presented at the "Fourth International Conference on Fission and Properties of Neutron-Rich nuclei", held at Sanibel Island, Florida, November 11-17, 2007

Published
2008
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5. Epidemiological, genetic, and clinical characterization by age of newly diagnosed acute myeloid leukemia based on an academic population-based registry study (AMLSG BiO)

Author

Nagel, Gabriele, Weber, D., Fromm, E., Erhardt, S., Lübbert, M., Fiedler, W., Kindler, T., Krauter, J., Brossart, P., Kündgen, A., Salih, H. R., Westermann, J., Wulf, G., Hertenstein, B., Wattad, M., Götze, K., Kraemer, D., Heinicke, T., Girschikofsky, M., Derigs, H.G., Horst, H. A., Rudolph, C., Heuser, M., Göhring, G., Teleanu, V., Bullinger, L., Thol, F., Gaidzik, V. I., Paschka, P., Döhner, K., Ganser, A., Döhner, Hartmut, Schlenk, R. F., and German-Austrian AML Study Group (AMLSG)

Published
2017
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6. Therapeutic drug monitoring-guided treatment versus standard dosing of voriconazole for invasive aspergillosis in haematological patients: a multicentre, prospective, cluster randomised, crossover clinical trial

Author

Veringa, A., Bruggemann, R.J., Span, L.F.R., Biemond, B.J., Boer, M.G.J. de, Heuvel, E.R. van den, Klein, S.K., Kraemer, D., Minnema, M.C., Prakken, N.H.J., Rijnders, B.J.A., Swen, J.J., Verweij, P.E., Wondergem, M.J., Ypma, P.F., Blijlevens, N., Kosterink, J.G.W., Werf, T.S. van der, Alffenaar, J.W.C., Voriconazole ZonMw Study Grp, Hematology, AII - Cancer immunology, CCA - Cancer Treatment and quality of life, CCA - Cancer biology and immunology, ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), PharmacoTherapy, -Epidemiology and -Economics, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Microbes in Health and Disease (MHD), Clinical Haematology, AII - Inflammatory diseases, CCA - Cancer Treatment and Quality of Life, Cardiology, Eindhoven MedTech Innovation Center, Statistics, EAISI Foundational, EAISI Health, ICMS Core, and Internal Medicine

Subjects
Microbiology (medical), Adult, Adolescent, Voriconazole/adverse effects, Invasive Fungal Infections/drug therapy, Antifungal Agents/adverse effects, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], General Medicine, Haematological malignancy, Therapeutic drug monitoring, SDG 3 – Goede gezondheid en welzijn, All institutes and research themes of the Radboud University Medical Center, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Infectious Diseases, Invasive fungal infection, SDG 3 - Good Health and Well-being, Aspergillosis/drug therapy, Humans, Pharmacology (medical), Prospective Studies, Voriconazole, Drug Monitoring, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9], Retrospective Studies
Abstract

Objectives: Voriconazole therapeutic drug monitoring (TDM) is recommended based on retrospective data and limited prospective studies. This study aimed to investigate whether TDM-guided voriconazole treat-ment is superior to standard treatment for invasive aspergillosis.Methods: A multicentre ( n = 10), prospective, cluster randomised, crossover clinical trial was performed in haematological patients aged >= 18 years treated with voriconazole. All patients received standard voriconazole dose at the start of treatment. Blood/serum/plasma was periodically collected after treat-ment initiation of voriconazole and repeated during treatment in both groups. The TDM group had mea-sured voriconazole concentrations reported back, with dose adjustments made as appropriate, while the non-TDM group had voriconazole concentrations measured only after study completion. The composite primary endpoint included response to treatment and voriconazole treatment discontinuation due to an adverse drug reaction related to voriconazole within 28 days after treatment initiation. Results: In total, 189 patients were enrolled in the study. For the composite primary endpoint, 74 patients were included in the non-TDM group and 68 patients in the TDM group. Here, no significant difference was found between both groups ( P = 0.678). However, more trough concentrations were found within the generally accepted range of 1-6 mg/L for the TDM group (74.0%) compared with the non-TDM group (64.0%) ( P < 0.001). Conclusions: In this trial, TDM-guided dosing of voriconazole did not show improved treatment outcome compared with standard dosing. We believe that these findings should open up the discussion for an approach to voriconazole TDM that includes drug exposure, pathogen susceptibility and host defence. Clinical trial registration: ClinicalTrials.gov registration no. NCT00893555.(c) 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )

Published
2023

7. Acute myeloid leukemia derived from lympho-myeloid clonal hematopoiesis

Author

Thol, F, Klesse, S, Köhler, L, Gabdoulline, R, Kloos, A, Liebich, A, Wichmann, M, Chaturvedi, A, Fabisch, J, Gaidzik, V I, Paschka, P, Bullinger, L, Bug, G, Serve, H, Göhring, G, Schlegelberger, B, Lübbert, M, Kirchner, H, Wattad, M, Kraemer, D, Hertenstein, B, Heil, G, Fiedler, W, Krauter, J, Schlenk, R F, Döhner, K, Döhner, H, Ganser, A, and Heuser, M

Published
2017
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13. 2D-IR Photon Echo Spectroscopy of Liquid H2O — Combination of Novel Nanofluidics and Diffractive Optics Deciphers Ultrafast Structural Dynamics

Author

Paarmann, A., Kraemer, D., Cowan, M. L., Huse, N., Harb, M., Bruner, B. D., Dwyer, J. R., Nibbering, E. T. J., Elsaesser, T., Miller, R. J. D., Castleman, A. W., Jr., editor, Toennies, J. P., editor, Zinth, W., editor, Yamanouchi, K., editor, Corkum, Paul, editor, Jonas, David M., editor, Miller, R. J. Dwayne., editor, and Weiner, Andrew M., editor

Published
2007
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20. Butanol in the Frozen Spin Mode

Author

Dutz, H., Goertz, S., Krämer, D., Meyer, W., Reichertz, L., Reicherz, G., Thiel, W., Thomas, A., Weber, J., Meyer, Werner, editor, Steffens, Erhard, editor, and Thiel, Werner, editor

Published
1991
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33. Regional variations in fluid formation and metal sources in MVT mineralization in the Pennine Orefield, UK: Implications from rare earth element and yttrium distribution, Sr-Nd isotopes and fluid inclusion compositions of vein fluorites

Author

Kraemer, D, Viehmann, S, Banks, D, Sumoondur, AD, Koeberl, C, and Bau, M

Abstract

The Pennine Orefield is one of the most important ore fields for Pb-Zn-Ba-F mineralization in Great Britain. It is subdivided into the Northern Pennine Orefield (NPO), consisting of the Alston and Askrigg Blocks, and the Southern Pennine Orefield (SPO). The Alston Block is underlain by the early Devonian Weardale Granite and the Askrigg Block by the coeval Wensleydale Granite. The potential relationship between the batholiths and the mineralization is a matter of debate. We here studied the rare earth elements and Y (REY) geochemistry, Sr-Nd isotopes and fluid inclusion (FI) compositions of fluorites from the two structural blocks in the NPO and found that the fluorite mineralization in these blocks differ substantially. The REY in Askrigg fluorites show features that are characteristic for leaching of adjacent Lower Carboniferous limestones. In contrast, Alston fluorites have significantly higher REY concentrations, lack REYSN limestone signatures and show a decoupling of redox-sensitive Eu from its trivalent REY ‘neighbours’. Neodymium isotopes indicate a similar crustal source of REY in both blocks, but higher REY concentrations and lower Y/Ho ratios suggest Lower Carboniferous shales as potential REY source in the Alston Block. The fluids that precipitated the Alston fluorites experienced temperatures > 250 °C prior to mineral formation, as evidenced by Eu geothermometry. Fluorite formation, however, occurred at much lower temperatures, as suggested by homogenization temperatures in FI, that fall within ranges of 105–159 °C in Alston and 99–160 °C in Askrigg fluorites. Mineralization of the Mississippi- Valley Type usually lack association with igneous activity. We show that some of the fluids responsible for the NPO mineralization were influenced by magmatic sources. The REY systematics in Alston fluorites may be linked to an interaction of the Permian-age Whin Sill dolerite with the basement granite, which heated fluids and focussed fluid flow into the overlying sedimentary rocks. In the Askrigg Block, where such a dolerite intrusion was not described, fluorites lack any positive EuSN anomalies, indicating that these fluids had never been subjected to temperatures exceeding 200–250 °C.

Published
2019

34. Radiative equilibrium temperatures in the stratosphere and mesosphere ‐ A comparison for the stellar occultation and BUV ozone data

Author

Kuhn, WR, Kraemer, D, Cicerone, RJ, and Liu, S

Subjects
Meteorology & Atmospheric Sciences
Abstract

Recently published ozone densities in the equatorial stratosphere and mesosphere from satellite stellar occultation measurements are appreciably larger than previous independent midlatitude measurements and ozone densities predicted by photochemical theory. We have calculated radiative equilibrium temperature profiles with a stratosphere‐mesosphere optimized model for each of these ozone profiles and find that the stellar occultation studies cannot be discounted on energy balance grounds. Copyright 1978 by the American Geophysical Union.

Published
1978

39. Characterization of the electron source at the photo injector test facility at DESY Zeuthen

Author

Abrahamyan, K, Ackermann, W, Bähr, J, Bohnet, I, Carneiro, J.P, Cee, R, Flöttmann, K, Gensch, U, Grabosch, H.-J, Han, J.H, Hartrott, M.V, Jaeschke, E, Krämer, D, Krasilnikov, M, Lipka, D, Michelato, P, Miltchev, V, Müller, W.F.O, Oppelt, A, Pagani, C, Petrossyan, B, Roßbach, J, Sandner, W, Schreiber, S, Sertore, D, Setzer, S, Staykov, L, Stephan, F, Tsakov, I, Weiland, T, and Will, I

Published
2004
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45. First beam measurements at the photo injector test facility at DESY Zeuthen

Author

Bakker, R., Hartrott, M.v., Jaeschke, E., Krämer, D., Carneiro, J.P., Flöttmann, K., Piot, P., Roßbach, J., Schreiber, S., Abrahamyan, K., Bähr, J., Bohnet, I., Djordjadze, V., Gensch, U., Graboschi, H.J., Li, Z., Lipka, D., Oppelt, A., Petrossyan, B., Stephan, F., Michelato, P., Pagani, C., Sertore, D., Miltchev, V., Tsakov, I., Liero, A., Redlin, H., Sandner, W., Schumann, R., Will, I., Cee, R., Krassilnikov, M., Setzer, S., and Weiland, T.

Published
2003
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47. Gunter Blobel: Pioneer of molecular cell biology (1936-2018)

Author

Aitchison, JD, Albertini, M, Anderson, DJ, Aronow, B, Beckmann, R, Bera, M, Bergamin, E, Berman, D, Berrios, M, Blus, B, Bonatti, S, Bonifaci, N, Borgese, N, Chaudhary, N, Chauhan, R, Chaves, S, Chirico, WJ, Chook, Y, Conner, G, Courvalin, J-C, Coutavas, E, Debler, E, Denisenko, N, Devillers-Thiery, A, Fletcher, MD, Djabali, K, Dobberstein, B, Dwyer, N, Enenkel, C, Enninga, J, Erdmann, R, Erickson, A, Fan, J, Bridger, IF, Filson, A, Fisher, D, Fisher, RP, Fletcher, P, Floer, M, Fontoura, B, Friedlander, M, Gerace, L, Gilmore, R, Giudice, L, Gnadig, M, Gray, L, Greenburg, G, Hallberg, E, Hao, Q, Helmers, J, Hijikata, M, Hoelz, A, Hoiczyk, E, Hsia, K-C, Hunt, J, Hurwitz, M, Isberto, T, Johnson, E, Kampmann, M, Kaput, J, Katz, E, Kessler, F, Kim, HB, King, M, Koch-Brandt, C, Koh, J, Kraemer, D, Krolak, A, Li, X, Lingappa, VR, Lingappa, J, Lusk, P, Ma, Y, Matunis, MJ, McCune, M, Meier, T, Melcak, I, Mitchell, C, Moore, M, Moroianu, J, Muller, M, Nagy, V, Napetschnig, J, Nerhbass, U, Nicchitta, C, Nigam, SK, Nimic, G, Pain, D, Quirolgico, LR, Rahman, M, Ren, Y, Roa, M, Rout, MP, Schmidt, D, Schnell, D, Schuelke, N, Schwartz, T, Seo, H-S, Sharma, A, Shelness, G, Simon, S, Singh, N, Smith, S, Solmaz, SR, De Castillia, CS, Sun, J, Titov, A, Urnavicius, L, Wacker, D, Walter, P, Waters, G, Wente, SR, Wing, RA, Wong, R, Worman, H, Wozniak, RW, YaDeau, J, Yaseen, N, Yoshida, K, Zhao, X, and Zhong, H

Published
2018

48. Serum Chemokine-release Profiles in AML-patients Might Contribute to Predict the Clinical Course of the Disease

Author

Merle, M., primary, Fischbacher, D., additional, Liepert, A., additional, Grabrucker, C., additional, Kroell, T., additional, Kremser, A., additional, Dreyssig, J., additional, Freudenreich, M., additional, Schuster, F., additional, Borkhardt, A., additional, Kraemer, D., additional, Koehne, C.-H., additional, Kolb, H. J., additional, Schmid, C., additional, and Schmetzer, H. M., additional

Published
2019
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49. Conversion of AML-blasts to leukemia-derived dendritic cells (DCleu) in ‘DC-culture-media’ shifts the (serum) chemokine-release profile to a more ‘inflammatory’ (in culture) going along with improved antileukemic T-cell-reactivity

Author

Merle, M., primary, Fischbacher, D., additional, Liepert, A., additional, Grabrucker, C., additional, Kroell, T., additional, Kremser, A., additional, Dreyssig, J., additional, Freudenreich, M., additional, Schuster, F., additional, Borkhardt, A., additional, Kraemer, D., additional, Koehne, C., additional, Kolb, H.J., additional, Schmid, C., additional, and Schmetzer, H.M., additional

Published
2019
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50. Modulation of AML-blasts with clinically approved response modifiers to leukemia-derived dendritic cells (DCleu) ex vivo: DC-, T-cell- and cytokine profiles are predictive for antileukemic T-cell reactivity

Author

Fischer, Z., primary, Deen, D., additional, Hirn, A., additional, Plett, C., additional, Kugler, C., additional, Rabe, A., additional, Liepert, A., additional, Freudenreich, M., additional, Kraemer, D., additional, Schmid, C., additional, and Schmetzer, H.M., additional

Published
2019
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