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2. Prognosis of impulse control disorders in Parkinson’s disease: a prospective controlled study

Author

Wirth, Thomas, Goetsch, Thibaut, Corvol, Jean-Christophe, Roze, Emmanuel, Mariani, Louise-Laure, Vidailhet, Marie, Grabli, David, Mallet, Luc, Pelissolo, Antoine, Rascol, Olivier, Brefel-Courbon, Christine, Ory-Magne, Fabienne, Arbus, Christophe, Bekadar, Samir, Krystkowiak, Pierre, Marques, Ana, Llorca, Michel, Krack, Paul, Castrioto, Anna, Fraix, Valérie, Maltete, David, Defebvre, Luc, Kreisler, Alexandre, Houeto, Jean-Luc, Tranchant, Christine, Meyer, Nicolas, and Anheim, Mathieu

Published
2024
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3. Role of sleep in neurodegeneration: the consensus report of the 5th Think Tank World Sleep Forum

Author

Ferini-Strambi, Luigi, Liguori, Claudio, Lucey, Brendan P., Mander, Bryce A., Spira, Adam P., Videnovic, Aleksandar, Baumann, Christian, Franco, Oscar, Fernandes, Mariana, Gnarra, Oriella, Krack, Paul, Manconi, Mauro, Noain, Daniela, Saxena, Smita, Kallweit, Ulf, Randerath, Winfried, Trenkwalder, C., Rosenzweig, Ivana, Iranzo, Alex, Bradicich, Matteo, and Bassetti, Claudio

Published
2024
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5. Long-Term Averaged Spectrum Descriptors of Dysarthria in Patients with Parkinson's Disease Treated with Subthalamic Nucleus Deep Brain Stimulation

Author

Svihlik, Jan, Novotny, Michal, Tykalova, Tereza, Polakova, Kamila, Brozova, Hana, Kryze, Petr, Sousa, Mario, Krack, Paul, Tripoliti, Elina, Ruzicka, Evzen, Jech, Robert, and Rusz, Jan

Abstract

Purpose: This study aimed to evaluate whether long-term averaged spectrum (LTAS) descriptors for reading and monologue are suitable to detect worsening of dysarthria in patients with Parkinson's disease (PD) treated with subthalamic nucleus deep brain stimulation (STN-DBS) with potential effect of ON and OFF stimulation conditions and types of connected speech. Method: Four spectral moments based on LTAS were computed for monologue and reading passage collected from 23 individuals with PD treated with bilateral STN-DBS and 23 age- and gender-matched healthy controls. Speech performance of patients with PD was compared in ON and OFF STN-DBS conditions. Results: All LTAS spectral moments including mean, standard deviation, skewness, and kurtosis across both monologue and reading passage were able to significantly distinguish between patients with PD in both stimulation conditions and control speakers. The spectral mean was the only LTAS measure sensitive to capture better speech performance in STN-DBS ON, as compared to the STN-DBS OFF stimulation condition (p < 0.05). Standardized reading passage was more sensitive compared to monologue in detecting dysarthria severity via LTAS descriptors with an area under the curve of up to 0.92 obtained between PD and control groups. Conclusions: Our findings confirmed that LTAS is a suitable approach to objectively describe changes in speech impairment severity due to STN-DBS therapy in patients with PD. We envisage these results as an important step toward a continuum development of technological solutions for the automated assessment of stimulation-induced dysarthria.

Published
2022
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6. Imbalanced motivated behaviors according to motor sign asymmetry in drug-naïve Parkinson’s disease

Author

Béreau, Matthieu, Castrioto, Anna, Servant, Mathieu, Lhommée, Eugénie, Desmarets, Maxime, Bichon, Amélie, Pélissier, Pierre, Schmitt, Emmanuelle, Klinger, Hélène, Longato, Nadine, Phillipps, Clélie, Wirth, Thomas, Fraix, Valérie, Benatru, Isabelle, Durif, Franck, Azulay, Jean-Philippe, Moro, Elena, Broussolle, Emmanuel, Thobois, Stéphane, Tranchant, Christine, Krack, Paul, and Anheim, Mathieu

Published
2023
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7. Correction to: Role of sleep in neurodegeneration: the consensus report of the 5th Think Tank World Sleep Forum

Author

Ferini‑Strambi, Luigi, Liguori, Claudio, Lucey, Brendan P., Mander, Bryce A., Spira, Adam P., Videnovic, Aleksandar, Baumann, Christian, Franco, Oscar, Fernandes, Mariana, Gnarra, Oriella, Krack, Paul, Manconi, Mauro, Noain, Daniela, Saxena, Smita, Kallweit, Ulf, Randerath, Winfried, Trenkwalder, C., Rosenzweig, Ivana, Iranzo, Alex, Bradicich, Matteo, and Bassetti, Claudio

Published
2024
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8. Creativity and Parkinson’s Disease

Author

Maradan-Gachet, Marie Elise, Debove, Ines, Lhommée, Eugénie, Krack, Paul, Tarsy, Daniel, Series Editor, Richard, Alby, editor, Pelowski, Matthew, editor, and Spee, Blanca T.M., editor

Published
2023
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9. Deep brain stimulation for obsessive–compulsive disorder: a crisis of access

Author

Visser-Vandewalle, Veerle, Andrade, Pablo, Mosley, Philip E., Greenberg, Benjamin D., Schuurman, Rick, McLaughlin, Nicole C., Voon, Valerie, Krack, Paul, Foote, Kelly D., Mayberg, Helen S., Figee, Martijn, Kopell, Brian H., Polosan, Mircea, Joyce, Eileen M., Chabardes, Stephan, Matthews, Keith, Baldermann, Juan C., Tyagi, Himanshu, Holtzheimer, Paul E., Bervoets, Chris, Hamani, Clement, Karachi, Carine, Denys, Damiaan, Zrinzo, Ludvic, Blomstedt, Patric, Naesström, Matilda, Abosch, Aviva, Rasmussen, Steven, Coenen, Volker A., Schlaepfer, Thomas E., Dougherty, Darin D., Domenech, Philippe, Silburn, Peter, Giordano, James, Lozano, Andres M., Sheth, Sameer A., Coyne, Terry, Kuhn, Jens, Mallet, Luc, Nuttin, Bart, Hariz, Marwan, and Okun, Michael S.

Published
2022
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10. Genetic stratification of motor and QoL outcomes in Parkinson's disease in the EARLYSTIM study

Author

Weiss, Daniel, Landoulsi, Zied, May, Patrick, Sharma, Manu, Schüpbach, Michael, You, Hana, Corvol, Jean Christophe, Paschen, Steffen, Helmers, Ann-Kristin, Barbe, Michael, Fink, Gereon, Kühn, Andrea A., Courbon, Christine Brefel, Wojtecki, Lars, Damier, Philippe, Fraix, Valerie, Houeto, Jean-Luc, Regis, Jean, Sixel-Döring, Friederike, Pinsker, Marcus O., Thobois, Stephane, Gharabaghi, Alireza, Stoker, Valerie, Timmermann, Lars, Schnitzler, Alfons, Krack, Paul, Vidailhet, Marie, Deuschl, Günther, and Krüger, Rejko

Published
2022
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11. Contributors

Author

Akram, Harith, primary, Al-Fatly, Bassam, additional, Alho, Eduardo Joaquim Lopes, additional, Baldermann, Juan Carlos, additional, Betzel, Richard F., additional, Boutet, Alexandre, additional, Butenko, K., additional, Choi, Ki Sueng, additional, Coenen, Volker A., additional, Deco, Gustavo, additional, Dembek, Till Anselm, additional, Dhollander, Thijs, additional, Elias, Gavin J.B., additional, Fernandes, Henrique M., additional, Ferreira, Francisca, additional, Fonoff, Erich Talamoni, additional, Fox, Michael D., additional, Germann, Jürgen, additional, Heinsen, Helmut, additional, Hertel, Frank, additional, Hollunder, Barbara, additional, Horn, Andreas, additional, Husch, Andreas, additional, Irmen, Friederike, additional, Jech, Robert, additional, Joutsa, Juho, additional, Krack, Paul, additional, Kringelbach, Morten L., additional, Kühn, Andrea A., additional, Lau, Jonathan C., additional, Li, Ningfei, additional, Lofredi, Roxanne, additional, Loh, Aaron, additional, Lozano, Andres M., additional, Mayberg, Helen, additional, Mueller, Karsten, additional, Neudorfer, Clemens, additional, Neumann, Wolf-Julian, additional, Oxenford, Simon, additional, Parmar, Roohie, additional, Perera, Thushara, additional, Rajamani, Nanditha, additional, Reisert, Marco, additional, van Rienen, U., additional, Shine, James M., additional, Siddiqi, Shan H., additional, Taha, Alaa, additional, Treu, Svenja, additional, Wong, Emily H.Y., additional, and Yang, Joseph Yuan-Mou, additional

Published
2022
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14. Early cognitive decline after bilateral subthalamic deep brain stimulation in Parkinson's disease patients with GBA mutations

Author

Benchetrit, Eve, Delaby, Laure, Berthet, Deborah, Danjou, Fabrice, Vidaihlet, Marie, Krack, Paul, Pelissier, Pierre, Morand, Dominique, Delaigue, Christine, Barun, Nadia, Anheim, Mathieu, Pleuvret, Marie, Destée, Alain, Defebvre, Luc, Moreau, Caroline, Simonin, Clémence, Ryckewaert, Gilles, Kreisler, Alexandre, Mutez, Eugénie, Carrière, Nicolas, Hopes, Lucie, Tard, Céline, Grolez, Guillaume, Dujardin, Kathy, Pecheux, Nathalie, Delliaux, Marie, Rolland, Anne-Sophie, Broussolle, Emmanuel, Laurencin, Chloè, Tison, François, Burbaud, Pierre, Mangone, Graziella, Bekadar, Samir, Cormier-Dequaire, Florence, Tahiri, Khadija, Welaratne, Arlette, Czernecki, Virginie, Pineau, Fanny, Karachi, Carine, Castrioto, Anna, Durif, Frank, Tranchant, Christine, Devos, David, Thobois, Stéphane, Meissner, Wassilios G, Navarro, Maria Soledad, Cornu, Philippe, Lesage, Suzanne, Brice, Alexis, Welter, Marie Laure, and Corvol, Jean-Christophe

Published
2020
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15. Lessons from multitarget neurostimulation in isolated dystonia: Less is more?

Author

Cuartero, Marie-Charlotte, primary, Grabli, David, additional, Flamand-Roze, Emmanuel, additional, Karachi, Carine, additional, Rouaud, Tiphaine, additional, Derkinderen, Pascal, additional, Damier, Philippe, additional, Raoul, Sylvie, additional, Krack, Paul, additional, Moro, Elena, additional, Fraix, Valérie, additional, Chabardès, Stéphan, additional, Burbaud, Pierre, additional, Guehl, Dominique, additional, Cuny, Emmanuel, additional, Pinto, Serge, additional, and Vidailhet, Marie, additional

Published
2024
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16. Subthalamic stimulation has acute psychotropic effects and improves neuropsychiatric fluctuations in Parkinson’s disease

Author

Magalhães, Andreia D, primary, Amstutz, Deborah, additional, Petermann, Katrin, additional, Debove, Ines, additional, Sousa, Mário, additional, Maradan-Gachet, Marie E, additional, Lachenmayer, Martin Lenard, additional, Waskönig, Julia, additional, Murcia-Carretero, Sandra, additional, Diamantaras, Andreas Antonios, additional, Tinkhauser, Gerd, additional, Nowacki, Andreas, additional, Pollo, Claudio, additional, Rodriguez-Blazquez, Carmen, additional, Martinez-Martin, Pablo, additional, and Krack, Paul, additional

Published
2024
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17. Role of sleep in neurodegeneration: the consensus report of the 5th Think Tank World Sleep Forum

Author

Ferini-Strambi, Luigi, primary, Liguori, Claudio, additional, Lucey, Brendan P., additional, Mander, Bryce A., additional, Spira, Adam P., additional, Videnovic, Aleksandar, additional, Baumann, Christian, additional, Franco, Oscar, additional, Fernandes, Mariana, additional, Gnarra, Oriella, additional, Krack, Paul, additional, Manconi, Mauro, additional, Noain, Daniela, additional, Saxena, Smita, additional, Kallweit, Ulf, additional, Randerath, Winfried, additional, Trenkwalder, C., additional, Rosenzweig, Ivana, additional, Iranzo, Alex, additional, and Bassetti, Claudio, additional

Published
2023
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20. What Parkinson's Reveals About the Artistic Spart

Author

Pelowski, Matthew, Spee, Blanca T.M., Richard, Alby, Krack, Paul, and Bloem, Bastiaan R.

Subjects
Creativity, Science and technology
Abstract

'I know that I am sick, and it is a horrible thing, but honestly I have never felt more artistic in my life.' --Parkinson's patient, personal correspondence with one of [...]

Published
2020

22. PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability

Author

Fevga, Christina, Tesson, Christelle, Carreras Mascaro, Ana, Courtin, Thomas, Van Coller, Riaan, Sakka, Salma, Ferraro, Federico, Farhat, Nouha, Bardien, Soraya, Damak, Mariem, Carr, Jonathan, Ferrien, Melanie, Boumeester, Valerie, Hundscheid, Jasmijn, Grillenzoni, Nicola, Kessissoglou, Irini A., Kuipers, Demy J.S., Quadri, Marialuisa, Agid, Yves, Anheim, Mathieu, Borg, Michel, Brice, Alexis, Broussolle, Emmanuel, Corvol, Jean Christophe, Damier, Philippe, Defebvre, Luc, Dürr, Alexandra, Durif, Franck, Houeto, Jean Luc, Krack, Paul, Klebe, Stephan, Lesage, Suzanne, Lohmann, Ebba, Martinez, Maria, Mangone, Graziella, Mariani, Louise Laure, Pollak, Pierre, Rascol, Olivier, Tison, François, Tranchant, Christine, Verin, Marc, Viallet, François, Vidailhet, Marie, Emre, Murat, Hanagasi, Hasmet, Bilgic, Basar, Lu, Bedia Marangozog, Benmahdjoub, Mustapha, Arezki, Mohammed, Bouchetara, Sofiane A., Benhassine, Traki, Tazir, Meriem, Djebara, Mouna Ben, Gouider, Riadh, Romdhan, Sawssan Ben, Mhiri, Chokri, Bouhouche, Ahmed, Bonifati, Vincenzo, Mandemakers, Wim, Kievit, Anneke J.A., Boon, Agnita J.W., Ferreira, Joaquim J., Guedes, Leonor Correia, Hanagasi, Hasmet A., Tufekcioglu, Zeynep, Elibol, Bulent, Dog.u, Okan, Gultekin, Murat, Chien, Hsin F., Barbosa, Egberto, Jardim, Laura Bannach, Rieder, Carlos R.M., Chang, Hsiu Chen, Lu, Chin Song, Wu-Chou, Yah Huei, Yeh, Tu Hsueh, Lopiano, Leonardo, Tassorelli, Cristina, Pacchetti, Claudio, Comi, Cristoforo, Raudino, Francesco, Bertolasi, Laura, Tinazzi, Michele, Bonizzato, Alberto, Ferracci, Carlo, Marconi, Roberto, Guidi, Marco, Onofrj, Marco, Thomas, Astrid, Vanacore, Nicola, Meco, Giuseppe, Fabrizio, Edito, Fabbrini, Giovanni, Berardelli, Alfredo, Stocchi, Fabrizio, Vacca, Laura, Barone, Paolo, Picillo, Marina, De Michele, Giuseppe, Criscuolo, Chiara, De Mari, Michele, Dell'aquila, Claudia, Iliceto, Giovanni, Toni, Vincenzo, Trianni, Giorgio, Saddi, Valeria, Cossu, Gianni, Melis, Maurizio, Hassan, Bassem A., Breedveld, Guido J., Erasmus University Medical Center [Rotterdam] (Erasmus MC), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de Génétique médicale [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Faculty of Health Sciences [Pretoria], University of Pretoria [South Africa], Hopital Habib Bourguiba - Habib Bourguiba Hospital [Sfax], Stellenbosch University, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Motivation, cerveau et comportement = Motivation, Brain and Behavior [ICM Paris] (MBB), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Tesson, Christelle, Clinical Genetics, and Neurology

Subjects
[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, intellectual disability, PTPA, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], PPP2R4, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, parkinsonism, PP2A
Abstract

The protein phosphatase 2A complex (PP2A), the major Ser/Thr phosphatase in the brain, is involved in a number of signalling pathways and functions, including the regulation of crucial proteins for neurodegeneration, such as alpha-synuclein, tau and LRRK2. Here, we report the identification of variants in the PTPA/PPP2R4 gene, encoding a major PP2A activator, in two families with early-onset parkinsonism and intellectual disability. We carried out clinical studies and genetic analyses, including genome-wide linkage analysis, whole-exome sequencing, and Sanger sequencing of candidate variants. We next performed functional studies on the disease-associated variants in cultured cells and knock-down of ptpa in Drosophila melanogaster. We first identified a homozygous PTPA variant, c.893T>G (p.Met298Arg), in patients from a South African family with early-onset parkinsonism and intellectual disability. Screening of a large series of additional families yielded a second homozygous variant, c.512C>A (p.Ala171Asp), in a Libyan family with a similar phenotype. Both variants co-segregate with disease in the respective families. The affected subjects display juvenile-onset parkinsonism and intellectual disability. The motor symptoms were responsive to treatment with levodopa and deep brain stimulation of the subthalamic nucleus. In overexpression studies, both the PTPA p.Ala171Asp and p.Met298Arg variants were associated with decreased PTPA RNA stability and decreased PTPA protein levels; the p.Ala171Asp variant additionally displayed decreased PTPA protein stability. Crucially, expression of both variants was associated with decreased PP2A complex levels and impaired PP2A phosphatase activation. PTPA orthologue knock-down in Drosophila neurons induced a significant impairment of locomotion in the climbing test. This defect was age-dependent and fully reversed by L-DOPA treatment. We conclude that bi-allelic missense PTPA variants associated with impaired activation of the PP2A phosphatase cause autosomal recessive early-onset parkinsonism with intellectual disability. Our findings might also provide new insights for understanding the role of the PP2A complex in the pathogenesis of more common forms of neurodegeneration.

Published
2023

24. Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson's disease with early motor complications (EARLYSTIM trial): secondary analysis of an open-label randomised trial

Author

Negovanska, Velina, Welter, Marie-Laure, Corvol, Jean-Christophe, Agid, Yves, Navarro, Soledad, Meier, Niklaus, Hartmann, Andreas, Hesekamp, Helke, Cornu, Philippe, Möller, Bettina, Nebel, Adelheid, Raethjen, Jan, Knudsen, Karina, Volkmann, Jens, Falk, Daniela, Paschen, Steffen, Meister, Ingo, Kuhn, Jens, Donner, Kerstin, Kessler, Josef, Barbe, Michael, Fink, Gereon, Maarouf, Mohammad, Kühn, Andrea, Müller, Bianca, Faust, Katharina, Gruber, Doreen, Schneider, Gerd-H., Seigneuret, Eric, Pollak, Pierre, Fraix, Valerie, Kistner, Andrea, Rascol, Olivier, Arbus, Christophe, Danet, Lola, Chaynes, Patrick, Groiss, Stefan J., Hartmann, Christian, Südmeyer, Martin, Partowinia-Peters, Mahnaz, Vesper, Jan, Ledily, Severine, Damier, Philippe, Raoul, Sylvie, Trenkwalder, Claudia, Richter-Dreske, Wenke, Wächter, Tobias, Weiss, Daniel, Eusebio, Alexandro, Azulay, Jean Philippe, Polo, Gustavo, Pinto, Serge, Levin, Johannes, Dornier, Stephanie, Pene, Fredy, Hourton, Delphine, Quintin, Mathieu, Hoffart-Jourdain, Cecile, Brocvielle, Helene, Balthasar, Kerstin, Stein, Meryem, Harnisch, Susanne, Reuss, Alexander, Aminossadati, Behnaz, Nasemann, Christian, Oertel, Wolfgang, Bataille, Benoit, Hellwig, Dieter, Gharabaghi, Alireza, Amtage, Florian, Mertens, Patrick, Kloss, Manja, Post, Bart, Speelman, Hans, Lhommée, Eugénie, Wojtecki, Lars, Czernecki, Virginie, Witt, Karsten, Maier, Franziska, Tonder, Lisa, Timmermann, Lars, Hälbig, Thomas D, Pineau, Fanny, Durif, Franck, Witjas, Tatiana, Pinsker, Marcus, Mehdorn, Maximilian, Sixel-Döring, Friederike, Kupsch, Andreas, Krüger, Rejko, Elben, Saskia, Chabardès, Stephan, Thobois, Stéphane, Brefel-Courbon, Christine, Ory-Magne, Fabienne, Regis, Jean-Marie, Maltête, David, Sauvaget, Anne, Rau, Jörn, Schnitzler, Alfons, Schüpbach, Michael, Schade-Brittinger, Carmen, Deuschl, Gunther, Houeto, Jean-Luc, and Krack, Paul

Published
2018
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25. Postoperative rehabilitation after deep brain stimulation surgery for movement disorders

Author

Allert, Niels, Cheeran, Binith, Deuschl, Günther, Barbe, Michael T., Csoti, Ilona, Ebke, Markus, Glaser, Martin, Kang, Jun-Suk, Kelm, Stefan, Krack, Paul, Kroth, Julia, Jobst, Ulrich, Leisse, Markus, Oliviero, Antonio, Nolte, Peter Nikolaus, Quick-Weller, Johanna, Strothjohann, Martin, Tamás, Gertrúd, Werner, Michael, Muthuraman, Muthuraman, Volkmann, Jens, Fasano, Alfonso, and Groppa, Sergiu

Published
2018
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27. Deep Brain Stimulation: When to Test Directional?

Author

Debove, Ines, Petermann, Katrin, Nowacki, Andreas, Nguyen, Thuy-Anh Khoa, Tinkhauser, Gerd, Michelis, Joan Philipp, Muellner, Julia, Amstutz, Deborah, Bargiotas, Panagiotis, Fichtner, Jens, Schläppi, Janine Ai, Krack, Paul, Schuepbach, Michael, Pollo, Claudio, and Lachenmayer, Martin Lenard

Subjects
Neurology, 570 Life sciences, biology, 610 Medicine & health, Neurology (clinical)
Abstract

BACKGROUND Directional deep brain stimulation (DBS) allows for steering of the stimulation field, but extensive and time-consuming testing of all segmented contacts is necessary to identify the possible benefit of steering. It is therefore important to determine under which circumstances directional current steering is advantageous. METHODS Fifty two Parkinson's disease patients implanted in the STN with a directional DBS system underwent a standardized monopolar programming session 5 to 9 months after implantation. Individual contacts were tested for a potential advantage of directional stimulation. Results were used to build a prediction model for the selection of ring levels that would benefit from directional stimulation. RESULTS On average, there was no significant difference in therapeutic window between ring-level contact and best directional contact. However, according to our standardized protocol, 35% of the contacts and 66% of patients had a larger therapeutic window under directional stimulation compared to ring-mode. The segmented contacts warranting directional current steering could be predicted with a sensitivity of 79% and a specificity of 57%. CONCLUSION To reduce time required for DBS programming, we recommend additional directional contact testing initially only on ring-level contacts with a therapeutic window of less than 2.0 mA.

Published
2023

32. A Transferable Lidar-Based Method to Conduct Contactless Assessments of Gait Parameters in Diverse Home-like Environments.

Author

Single, Michael, Bruhin, Lena C., Colombo, Aaron, Möri, Kevin, Gerber, Stephan M., Lahr, Jacob, Krack, Paul, Klöppel, Stefan, Müri, René M., Mosimann, Urs P., and Nef, Tobias

Subjects
GAIT in humans, HUMAN mechanics, MATHEMATICAL morphology, VIDEO recording, OLDER people, ANKLE
Abstract

Gait abnormalities in older adults are linked to increased risks of falls, institutionalization, and mortality, necessitating accurate and frequent gait assessments beyond traditional clinical settings. Current methods, such as pressure-sensitive walkways, often lack the continuous natural environment monitoring needed to understand an individual's gait fully during their daily activities. To address this gap, we present a Lidar-based method capable of unobtrusively and continuously tracking human leg movements in diverse home-like environments, aiming to match the accuracy of a clinical reference measurement system. We developed a calibration-free step extraction algorithm based on mathematical morphology to realize Lidar-based gait analysis. Clinical gait parameters of 45 healthy individuals were measured using Lidar and reference systems (a pressure-sensitive walkway and a video recording system). Each participant participated in three predefined ambulation experiments by walking over the walkway. We observed linear relationships with strong positive correlations ( R 2 > 0.9 ) between the values of the gait parameters (step and stride length, step and stride time, cadence, and velocity) measured with the Lidar sensors and the pressure-sensitive walkway reference system. Moreover, the lower and upper 95% confidence intervals of all gait parameters were tight. The proposed algorithm can accurately derive gait parameters from Lidar data captured in home-like environments, with a performance not significantly less accurate than clinical reference systems. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Management of Impulse Control and Related Disorders in Parkinson's Disease: An Expert Consensus.

Author

Debove, Ines, Paschen, Steffen, Amstutz, Deborah, Cardoso, Francisco, Corvol, Jean‐Christophe, Fung, Victor S.C., Lang, Anthony E., Martinez Martin, Pablo, Rodríguez‐Oroz, María C., Weintraub, Daniel, Krack, Paul, Deuschl, Günther, Sarfo, Fred Stephen, Akpalu, Albert Kwaku, Okubadejo, Njideka, Shalash, Ali Soliman, Hattori, Nobutaka, Lee, Jee‐Young, O'Sullivan, Sean, and Antonini, Angelo

Abstract

Background: Impulse‐control and related behavioral disorders (ICBDs) significantly impact the lives of Parkinson's disease (PD) patients and caregivers, with lasting consequences if undiagnosed and untreated. While ICBD pathophysiology and risk factors are well‐studied, a standardized severity definition and treatment evidence remain elusive. Objective: This work aimed to establish international expert consensus on ICBD treatment strategies. To comprehensively address diverse treatment availabilities, experts from various continents were included. Methods: From 2021 to 2023, global movement disorders specialists engaged in a Delphi process. A core expert group initiated surveys, involving a larger panel in three iterations, leading to refined severity definitions and treatment pathways. Results: Experts achieved consensus on defining ICBD severity, emphasizing regular PD patient screenings for early detection. General treatment recommendations focused on continuous monitoring, collaboration with significant others, and seeking specialist advice for legal or financial challenges. For mild to severe ICBDs, gradual reduction in dopamine agonists was endorsed, followed by reductions in other PD medications. Second‐line treatment strategies included diverse approaches like reversing the last medication change, cognitive behavior therapy, subthalamic nucleus deep brain stimulation, and specific medications like quetiapine, clozapine, and antidepressants. The panel reached consensus on distinct treatment pathways for punding and dopamine dysregulation syndrome, formulating therapy recommendations. Comprehensive discussions addressed management strategies for the exacerbation of either motor or non‐motor symptoms following the proposed treatments. Conclusion: The consensus offers in‐depth insights into ICBD management, presenting clear severity criteria and expert consensus treatment recommendations. The study highlights the critical need for further research to enhance ICBD management. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Electroencephalographic Abnormalities in a Patient Suffering from Long-Term Neuropsychological Complications following SARS-CoV-2 Infection.

Author

Benis, Damien, Voruz, Philippe, Chiuve, Sabina Catalano, Garibotto, Valentina, Assal, Frédéric, Krack, Paul, Péron, Julie, and Fleury, Vanessa

Subjects
APATHY, POST-acute COVID-19 syndrome, SLEEP interruptions, ELECTROENCEPHALOGRAPHY, SARS-CoV-2, GAMING disorder
Abstract

Introduction: Emotional apathy has recently been identified as a common symptom of long COVID. While recent meta-analyses have demonstrated generalized EEG slowing with the emergence of delta rhythms in patients hospitalized for severe SARS-CoV-2 infection, no EEG study or dopamine transporter scintigraphy (DaTSCAN) has been performed in patients with long COVID presenting with apathy. The objective of this case report was to explore the pathophysiology of neuropsychological symptoms in long COVID. Case Presentation: A 47-year-old patient who developed a long COVID with prominent apathy following an initially clinically mild SARS-CoV-2 infection underwent neuropsychological assessment, cerebral MRI, DaTSCAN, and resting-state high-density EEG 7 months after SARS-CoV-2 infection. The EEG data were compared to those of 21 healthy participants. The patient presented with apathy, cognitive difficulties with dysexecutive syndrome, moderate attentional and verbal episodic memory disturbances, and resolution of premorbid mild gaming disorder, mild mood disturbances, and sleep disturbances. His MRI and DaTSCAN were unremarkable. EEG revealed a complex pattern of oscillatory abnormalities compared to the control group, with a strong increase in whole-scalp delta and beta band activity, as well as a decrease in alpha band activity. Overall, these effects were more prominent in the frontal-central-temporal region. Conclusion: These results suggest widespread changes in EEG oscillatory patterns in a patient with long COVID characterized by neuropsychological complications with prominent apathy. Despite the inherent limitations of a case report, these results suggest dysfunction in the cortical networks involved in motivation and emotion. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Quality of life predicts outcome of deep brain stimulation in early Parkinson disease

Author

Schuepbach, W.M. Michael, Tonder, Lisa, Schnitzler, Alfons, Krack, Paul, Rau, Joern, Hartmann, Andreas, Hälbig, Thomas, Pineau, Fanny, Falk, Andrea, Paschen, Laura, Paschen, Stephen, Volkmann, Jens, Dafsari, Haidar S., Barbe, Michael T., Fink, Gereon R., Kühn, Andrea, Kupsch, Andreas, Schneider, Gerd-H., Seigneuret, Eric, Fraix, Valerie, Kistner, Andrea, Chaynes, P. Patrick, Ory-Magne, Fabienne, Brefel-Courbon, Christine, Vesper, Jan, Wojtecki, Lars, Derrey, Stéphane, Maltête, David, Damier, Philippe, Derkinderen, Pascal, Sixel-Döring, Friederike, Trenkwalder, Claudia, Gharabaghi, Alireza, Wächter, Tobias, Weiss, Daniel, Pinsker, Marcus O., Regis, Jean-Marie, Witjas, Tatiana, Thobois, Stephane, Mertens, Patrick, Knudsen, Karina, Schade-Brittinger, Carmen, Houeto, Jean-Luc, Agid, Yves, Vidailhet, Marie, Timmermann, Lars, and Deuschl, Günther

Published
2019
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39. Imbalanced motivated behaviors according to motor sign asymmetry in drug-naïve Parkinson’s Disease

Author

Béreau, Matthieu, primary, Castrioto, Anna, additional, Servant, Mathieu, additional, Lhommée, Eugénie, additional, Desmarets, Maxime, additional, Bichon, Amélie, additional, Pelissier, Pierre, additional, Schmitt, Emmanuelle, additional, Klinger, Hélène, additional, Longato, Nadine, additional, Phillipps, Clélie, additional, Wirth, Thomas, additional, Fraix, Valérie, additional, Benatru, Isabelle, additional, Durif, Franck, additional, Azulay, Jean-Philippe, additional, Moro, Elena, additional, Broussolle, Emmanuel, additional, Thobois, Stéphane, additional, Tranchant, Christine, additional, Krack, Paul, additional, and Anheim, Mathieu, additional

Published
2023
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40. Spectral Topography of the Subthalamic Nucleus to Inform Next‐Generation Deep Brain Stimulation

Author

Averna, Alberto, primary, Debove, Ines, additional, Nowacki, Andreas, additional, Peterman, Katrin, additional, Duchet, Benoit, additional, Sousa, Mário, additional, Bernasconi, Elena, additional, Alva, Laura, additional, Lachenmayer, Martin L., additional, Schuepbach, Michael, additional, Pollo, Claudio, additional, Krack, Paul, additional, Nguyen, Thuy‐Anh K., additional, and Tinkhauser, Gerd, additional

Published
2023
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41. Concerns about the European academy's recommendations and guidelines regarding pallidotomy for Parkinson's disease

Author

Hariz, Marwan, Bronstein, Jeff M., Cosgrove, G. Rees, de Bie, Rob M. A., DeLong, Mahlon R., Gross, Robert E., Krack, Paul, Krauss, Joachim K., Lang, Anthony E., Lees, Andrew J., Lozano, Andres M., Obeso, José A., Schuurman, P. Richard, Vitek, Jerrold L., Hariz, Marwan, Bronstein, Jeff M., Cosgrove, G. Rees, de Bie, Rob M. A., DeLong, Mahlon R., Gross, Robert E., Krack, Paul, Krauss, Joachim K., Lang, Anthony E., Lees, Andrew J., Lozano, Andres M., Obeso, José A., Schuurman, P. Richard, and Vitek, Jerrold L.

Published
2023
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42. European academy of neurology/movement disorder society–european section guidelines on pallidotomy for parkinson's disease

Author

Hariz, Marwan, Bronstein, Jeff M., Cosgrove, G. Rees, de Bie, Rob M.A., DeLong, Mahlon R., Gross, Robert E., Krack, Paul, Krauss, Joachim K., Lang, Anthony E., Lees, Andrew J., Lozano, Andres M., Obeso, José A., Schuurman, P. Richard, Vitek, Jerold L., Hariz, Marwan, Bronstein, Jeff M., Cosgrove, G. Rees, de Bie, Rob M.A., DeLong, Mahlon R., Gross, Robert E., Krack, Paul, Krauss, Joachim K., Lang, Anthony E., Lees, Andrew J., Lozano, Andres M., Obeso, José A., Schuurman, P. Richard, and Vitek, Jerold L.

Abstract

Previously published with title: "European academy of neurology/movement disorder society–european section guidelines on pallidotomy for parkinson's disease: let's be accurate".

Published
2023
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43. An Overview of Wearable Haptic Technologies and Their Performance in Virtual Object Exploration

Author

van Wegen, M. (author), Herder, J.L. (author), Adelsberger, Rolf (author), Pastore-Wapp, Manuela (author), Van Wegen, Erwin E H (author), Bohlhalter, Stephan (author), Nef, Tobias (author), Krack, Paul (author), Vanbellingen, Tim (author), van Wegen, M. (author), Herder, J.L. (author), Adelsberger, Rolf (author), Pastore-Wapp, Manuela (author), Van Wegen, Erwin E H (author), Bohlhalter, Stephan (author), Nef, Tobias (author), Krack, Paul (author), and Vanbellingen, Tim (author)

Abstract

We often interact with our environment through manual handling of objects and exploration of their properties. Object properties (OP), such as texture, stiffness, size, shape, temperature, weight, and orientation provide necessary information to successfully perform interactions. The human haptic perception system plays a key role in this. As virtual reality (VR) has been a growing field of interest with many applications, adding haptic feedback to virtual experiences is another step towards more realistic virtual interactions. However, integrating haptics in a realistic manner, requires complex technological solutions and actual user-testing in virtual environments (VEs) for verification. This review provides a comprehensive overview of recent wearable haptic devices (HDs) categorized by the OP exploration for which they have been verified in a VE. We found 13 studies which specifically addressed user-testing of wearable HDs in healthy subjects. We map and discuss the different technological solutions for different OP exploration which are useful for the design of future haptic object interactions in VR, and provide future recommendations., Precision and Microsystems Engineering

Published
2023
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49. Development of an Open-source and Lightweight Sensor Recording Software System for Conducting Biomedical Research: Technical Report

Author

Single, Michael, primary, Bruhin, Lena C, additional, Schütz, Narayan, additional, Naef, Aileen C, additional, Hegi, Heinz, additional, Reuse, Pascal, additional, Schindler, Kaspar A, additional, Krack, Paul, additional, Wiest, Roland, additional, Chan, Andrew, additional, Nef, Tobias, additional, and Gerber, Stephan M, additional

Published
2023
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50. Combining Multimodal Biomarkers to Guide Deep Brain Stimulation Programming in Parkinson Disease

Author

Shah, Ashesh, primary, Nguyen, Thuy-Anh Khoa, additional, Peterman, Katrin, additional, Khawaldeh, Saed, additional, Debove, Ines, additional, Shah, Syed Ahmar, additional, Torrecillos, Flavie, additional, Tan, Huiling, additional, Pogosyan, Alek, additional, Lachenmayer, Martin Lenard, additional, Michelis, Joan, additional, Brown, Peter, additional, Pollo, Claudio, additional, Krack, Paul, additional, Nowacki, Andreas, additional, and Tinkhauser, Gerd, additional

Published
2023
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