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17 results on '"Krabben, Annemarie"'

8. Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis

Author

de Rooy, Diederik P C, Yeremenko, Nataliya G, Wilson, Anthony Gerard, Knevel, Rachel, Lindqvist, Elisabet, Saxne, Tore, Krabben, Annemarie, Leijsma, Martha K, Daha, Nina A, Tsonaka, S, Zhernakova, A, Houwing-Duistermaat, J J, Huizinga, Tom W J, Toes, René E M, Baeten, Dominique L P, Brouwer, E, and van der Helm-van Mil, Annette H M

Published
2013
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12. Associations between APOE Genotypes and Disease Susceptibility, Joint Damage and Lipid Levels in Patients with Rheumatoid Arthritis

Author

Maehlen, Marthe T., Provan, Sella A., de Rooy, Diederik P. C., van der Helm-van Mil, Annette H. M., Krabben, Annemarie, Saxne, Tore, Lindqvist, Elisabet, Semb, Anne Grete, Uhlig, Till, van der Heijde, Desiree, Mero, Inger Lise, Olsen, Inge C., Kvien, Tore K., Lie, Benedicte A., Maehlen, Marthe T., Provan, Sella A., de Rooy, Diederik P. C., van der Helm-van Mil, Annette H. M., Krabben, Annemarie, Saxne, Tore, Lindqvist, Elisabet, Semb, Anne Grete, Uhlig, Till, van der Heijde, Desiree, Mero, Inger Lise, Olsen, Inge C., Kvien, Tore K., and Lie, Benedicte A.

Abstract

Objective: Apolipoprotein E (APOE) genotypes are associated with cardiovascular disease (CVD) and lipid levels. In rheumatoid arthritis (RA), an association has been found with disease activity. We examined the associations between APOE genotypes and disease susceptibility and markers of disease severity in RA, including radiographic joint damage, inflammatory markers, lipid levels and cardiovascular markers. Method: A Norwegian cohort of 945 RA patients and 988 controls were genotyped for two APOE polymorphisms. We examined longitudinal associations between APOE genotypes and C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) as well as hand radiographs (van der Heijde Sharp Score(SHS)) in 207 patients with 10 year longitudinal data. Lipid levels, cardiovascular markers and history of CVD were compared across genotypes in a cross sectional study of 136 patients. Longitudinal radiological data of cohorts from Lund and Leiden were available for replication. (N = 935, with 4799 radiographs). Results: In the Norwegian cohort, associations between APOE genotypes and total cholesterol (TC) and low-density lipoproteins (LDL) were observed (epsilon 2

Published
2013

15. Associations between APOE Genotypes and Disease Susceptibility, Joint Damage and Lipid Levels in Patients with Rheumatoid Arthritis

Author

Maehlen, Marthe T., primary, Provan, Sella A., additional, de Rooy, Diederik P. C., additional, van der Helm - van Mil, Annette H. M., additional, Krabben, Annemarie, additional, Saxne, Tore, additional, Lindqvist, Elisabet, additional, Semb, Anne Grete, additional, Uhlig, Till, additional, van der Heijde, Désirée, additional, Mero, Inger Lise, additional, Olsen, Inge C., additional, Kvien, Tore K., additional, and Lie, Benedicte A., additional

Published
2013
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16. Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis

Author

de Rooy, Diederik P C, primary, Yeremenko, Nataliya G, additional, Wilson, Anthony Gerard, additional, Knevel, Rachel, additional, Lindqvist, Elisabet, additional, Saxne, Tore, additional, Krabben, Annemarie, additional, Leijsma, Martha K, additional, Daha, Nina A, additional, Tsonaka, S, additional, Zhernakova, A, additional, Houwing-Duistermaat, J J, additional, Huizinga, Tom W J, additional, Toes, René E M, additional, Baeten, Dominique L P, additional, Brouwer, E, additional, and van der Helm-van Mil, Annette H M, additional

Published
2012
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