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1. Magnetic Resonance Imaging Predictors for Clinical Response in Patients with Axial Spondyloarthritis Treated with Tumor Necrosis Factor Inhibitors.

Author

Krabbe, S., Pedersen, S.J., Sørensen, I.J., Møller, J., and Østergaard, M.

Subjects
*MAGNETIC resonance imaging, *TUMOR necrosis factors, *SPONDYLOARTHROPATHIES
Abstract

This article discusses the use of magnetic resonance imaging (MRI) to predict clinical response in patients with axial spondyloarthritis who are treated with tumor necrosis factor (TNF) inhibitors. The study analyzed MRI features of the sacroiliac joints and spine in 102 patients and found that higher scores for inflammation, erosion, and backfill in the sacroiliac joints were significant predictors for treatment response. Additionally, certain subscores for spine inflammation were borderline predictive for response. The study suggests that these MRI features could be useful in developing prediction models for treatment response in patients with axial spondyloarthritis. [Extracted from the article]

Published
2024
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2. POS0918 VALIDATION OF A MODIFIED NEW YORK CRITERIA RETIC E-TOOL FOR INCREASING SCORING PROFICIENCY OF RADIOGRAPHS OF THE SACROILIAC JOINTS IN AXIAL SPONDYLOARTHRITIS

Author

Hadsbjerg, A. E. F., primary, Østergaard, M., additional, Paschke, J., additional, Micheroli, R., additional, Pedersen, S. J., additional, Ciurea, A., additional, Nissen, M. J., additional, Bubova, K., additional, Wichuk, S., additional, De Hooge, M., additional, Krabbe, S., additional, Mathew, A. J., additional, Gregová, M., additional, Wetterslev, M., additional, Gorican, K., additional, Pintaric, K., additional, Snoj, Z., additional, Moeller, B., additional, Bernatschek, A., additional, Donzallaz, M., additional, Lambert, R. G., additional, and Maksymowych, W. P., additional

Published
2023
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4. Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease — An ECCO-EpiCom study

Author

Burisch, J., Weimers, P., Pedersen, N., Cukovic-Cavka, S., Vucelic, B., Kaimakliotis, I., Duricova, D., Bortlik, M., Shonová, O., Vind, I., Avnstrøm, S., Thorsgaard, N., Krabbe, S., Andersen, V., Dahlerup, J.F., Kjeldsen, J., Salupere, R., Olsen, J., Nielsen, K.R., Manninen, P., Collin, P., Katsanos, K.H., Tsianos, E.V., Ladefoged, K., Lakatos, L., Ragnarsson, G., Björnsson, E., Bailey, Y., O'Morain, C., Schwartz, D., Odes, S., Valpiani, D., Boni, M.C., Jonaitis, L., Kupcinskas, L., Turcan, S., Barros, L., Magro, F., Lazar, D., Goldis, A., Nikulina, I., Belousova, E., Fernandez, A., Sanroman, L., Almer, S., Zhulina, Y., Halfvarson, J., Arebi, N., Diggory, T., Sebastian, S., Lakatos, P.L., Langholz, E., and Munkholm, P.

Published
2014
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5. Health care and patients' education in a European inflammatory bowel disease inception cohort: An ECCO-EpiCom study

Author

Burisch, J., Vegh, Z., Pedersen, N., Čuković-Čavka, S., Turk, N., Kaimakliotis, I., Duricova, D., Bortlik, M., Shonová, O., Thorsgaard, N., Krabbe, S., Andersen, V., Dahlerup, J.F., Kjeldsen, J., Salupere, R., Olsen, J., Nielsen, K.R., Manninen, P., Collin, P., Katsanos, K.H., Tsianos, E.V., Ladefoged, K., Ragnarsson, G., Björnsson, E., Bailey, Y., O'Morain, C., Schwartz, D., Odes, S., Politi, P., Santini, A., Kiudelis, G., Kupcinskas, L., Turcan, S., Magro, F., Barros, L., Lazar, D., Goldis, A., Nikulina, I., Belousova, E., Sanromán, L., Martinez-Ares, D., Almer, S., Zhulina, Y., Halfvarson, J., Arebi, N., Houston, Y., Sebastian, S., Langholz, E., Lakatos, P.L., and Munkholm, P.

Published
2014
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6. Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe — An ECCO-EpiCom study

Author

Burisch, J., Pedersen, N., Cukovic-Cavka, S., Turk, N., Kaimakliotis, I., Duricova, D., Bortlik, M., Shonová, O., Vind, I., Avnstrøm, S., Thorsgaard, N., Krabbe, S., Andersen, V., Dahlerup, J.F., Kjeldsen, J., Salupere, R., Olsen, J., Nielsen, K.R., Manninen, P., Collin, P., Katsanos, K.H., Tsianos, E.V., Ladefoged, K., Lakatos, L., Ragnarsson, G., Björnsson, E., Bailey, Y., O'Morain, C., Schwartz, D., Odes, S., Giannotta, M., Girardin, G., Kiudelis, G., Kupcinskas, L., Turcan, S., Barros, L., Magro, F., Lazar, D., Goldis, A., Nikulina, I., Belousova, E., Martinez-Ares, D., Hernandez, V., Almer, S., Zhulina, Y., Halfvarson, J., Arebi, N., Tsai, H.H., Sebastian, S., Lakatos, P.L., Langholz, E., and Munkholm, P.

Published
2014
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7. CERTOLIZUMAB-PEGOL, ABATACEPT, TOCILIZUMAB OR ACTIVE CONVENTIONALTHERAPY IN EARLY RHEUMATOID ARTHRITIS: CLINICAL AND RADIOGRAPHIC 48-WEEKS RESULTS OF THE INVESTIGATOR-INITIATED RANDOMIZED NORD-STARTRIAL

Author

Østergaard, M., Van Vollenhoven, R., Rudin, A., Hetland, M. L., Heiberg, M., Nordström, D., Nurmohamed, M., Gudbjornsson, B., Ørnbjerg, L. Midtbøll, Bøyesen, P., Olsen, I., Lend, K., Hørslev-Petersen, K., Uhlig, T., Sokka-Isler, T., Gröndal, G., Krabbe, S., Lindqvist, J., Gjertsson, I., Glinatsi, D., Kapetanovic, M. C., Aga, A. B., Faustini, F., Parmanne, P., Lorenzen, T., Cagnotto, G., Back, J., Hendricks, O., Vedder, D., Rannio, T., Grenholm, E., Lindegaard, H. M., Ljosa, M. K. A., Brodin, E., Soderbergh, A., Rizk, M., Hermansson, E., Uhrenholt, L., Larsson, P., Just, S. A., Bakland, G., Stevens, D., Laurberg, T. B., Haavardsholm, E. A., and Lampa, J.

Published
2022

8. OP0058 CERTOLIZUMAB-PEGOL, ABATACEPT, TOCILIZUMAB OR ACTIVE CONVENTIONAL THERAPY IN EARLY RHEUMATOID ARTHRITIS: CLINICAL AND RADIOGRAPHIC 48-WEEKS RESULTS OF THE INVESTIGATOR-INITIATED RANDOMIZED NORD-STAR TRIAL

Author

Østergaard, M., primary, Van Vollenhoven, R., additional, Rudin, A., additional, Hetland, M. L., additional, Heiberg, M., additional, Nordström, D., additional, Nurmohamed, M., additional, Gudbjornsson, B., additional, Midtbøll Ørnbjerg, L., additional, Bøyesen, P., additional, Olsen, I., additional, Lend, K., additional, Hørslev-Petersen, K., additional, Uhlig, T., additional, Sokka-Isler, T., additional, Gröndal, G., additional, Krabbe, S., additional, Lindqvist, J., additional, Gjertsson, I., additional, Glinatsi, D., additional, Kapetanovic, M. C., additional, Aga, A. B., additional, Faustini, F., additional, Parmanne, P., additional, Lorenzen, T., additional, Cagnotto, G., additional, Back, J., additional, Hendricks, O., additional, Vedder, D., additional, Rannio, T., additional, Grenholm, E., additional, Lindegaard, H. M., additional, Ljosa, M. K. A., additional, Brodin, E., additional, Soderbergh, A., additional, Rizk, M., additional, Hermansson, E., additional, Uhrenholt, L., additional, Larsson, P., additional, Just, S. A., additional, Bakland, G., additional, Stevens, D., additional, Laurberg, T. B., additional, Haavardsholm, E. A., additional, and Lampa, J., additional

Published
2022
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10. OP0149 RELIABILITY AND RESPONSIVENESS OF TWO OMERACT WHOLE-BODY MRI SCORES OF ENTHESEAL AND JOINT INFLAMMATION IN THE KNEE REGION IN SPONDYLOARTHRITIS

Author

Wetterslev, M., primary, Maksymowych, W. P., additional, Lambert, R. G., additional, Eshed, I., additional, Juhl Pedersen, S., additional, Stoenoiu, M., additional, Krabbe, S., additional, Bird, P., additional, Foltz, V., additional, Mathew, A. J., additional, Gandjbakhch, F., additional, Paschke, J., additional, Carron, P., additional, De Marco, G., additional, Marzo-Ortega, H., additional, Poulsen, A. E. F., additional, Jaremko, J. L., additional, Conaghan, P. G., additional, and Østergaard, M., additional

Published
2021
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11. OP0252 ARTHRITIS AND ENTHESITIS IN THE HIP AND PELVIS REGION IN SPONDYLOARTHRITIS – VALIDATION OF TWO WHOLE-BODY MRI METHODS

Author

Wetterslev, M., primary, Lambert, R. G., additional, Maksymowych, W. P., additional, Eshed, I., additional, Juhl Pedersen, S., additional, Bird, P., additional, Stoenoiu, M., additional, Krabbe, S., additional, Mathew, A. J., additional, Foltz, V., additional, Gandjbakhch, F., additional, Paschke, J., additional, De Marco, G., additional, Marzo-Ortega, H., additional, Carron, P., additional, Poulsen, A. E. F., additional, Jaremko, J. L., additional, Conaghan, P. G., additional, and Østergaard, M., additional

Published
2021
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12. East–West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort

Author

Burisch, J, Pedersen, N, Čuković-Čavka, S, Brinar, M, Kaimakliotis, I, Duricova, D, Shonová, O, Vind, I, Avnstrøm, S, Thorsgaard, N, Andersen, V, Krabbe, S, Dahlerup, J F, Salupere, R, Nielsen, K R, Olsen, J, Manninen, P, Collin, P, Tsianos, E V, Katsanos, K H, Ladefoged, K, Lakatos, L, Björnsson, E, Ragnarsson, G, Bailey, Y, Odes, S, Schwartz, D, Martinato, M, Lupinacci, G, Milla, M, De Padova, A, DʼIncà, R, Beltrami, M, Kupcinskas, L, Kiudelis, G, Turcan, S, Tighineanu, O, Mihu, I, Magro, F, Barros, L F, Goldis, A, Lazar, D, Belousova, E, Nikulina, I, Hernandez, V, Martinez-Ares, D, Almer, S, Zhulina, Y, Halfvarson, J, Arebi, N, Sebastian, S, Lakatos, P L, Langholz, E, and Munkholm, P

Published
2014
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13. A MULTICENTER RANDOMIZED STUDY IN EARLY RHEUMATOID ARTHRITIS TO COMPARE ACTIVE CONVENTIONAL THERAPY VERSUS THREE BIOLOGICAL TREATMENTS: 24 WEEK EFFICACY RESULTS OF THE NORD-STAR TRIAL

Author

Kim Hørslev-Petersen, Merete Lund Hetland, Haavardsholm, E. A., Rudin, A., Nordstrom, D., Nurmohamed, M., Gudbjornsson, B., Lampa, J., Till Uhlig, Gröndal, G., Østergaard, M., Heiberg, M., Twisk, J., Krabbe, S., Lend, K., Olsen, I., Lindqvist, J., Ekwall, A. K. H., Grøn, Kathrine L., Kapetanovic, Meliha C., Francesca Faustini, Riitta Tuompo, Tove Lorenzen, Giovanni Cagnotto, Baecklund, E., Oliver Hendricks, Vedder, D., Tuulikki Sokka-isler, Tomas Husmark, Maud-Kristine Aga Ljosa, Eli Brodin, Torkell Ellingsen, Annika Soderbergh, Milad Rizk, Å, Reckner, Larsson, P., Uhrenholt, L., Just, S. A., David Stevens, Tb, Laurberg, Gunnstein Bakland, and Vollenhoven, Ronald F.

Abstract

OP0018 (2020) A MULTICENTER RANDOMIZED STUDY IN EARLY RHEUMATOID ARTHRITIS TO COMPARE ACTIVE CONVENTIONAL THERAPY VERSUS THREE BIOLOGICAL TREATMENTS: 24 WEEK EFFICACY RESULTS OF THE NORD-STAR TRIAL M. L. Hetland1, E. A. Haavardsholm1, A. Rudin1, D. Nordström1, M. Nurmohamed1, B. Gudbjornsson1, J. Lampa1, K. Hørslev-Petersen1, T. Uhlig1, G. Gröndal1, M. Ǿstergaard1, M. Heiberg1, J. Twisk1, S. Krabbe1, K. Lend1, I. Olsen1, J. Lindqvist1, A. K. H. Ekwall1, K. L. Grøn1, M. C. Kapetanovic1, F. Faustini1, R. Tuompo1, T. Lorenzen1, G. Cagnotto1, E. Baecklund1, O. Hendricks1, D. Vedder1, T. Sokka-Isler1, T. Husmark1, M. K. A. Ljosa1, E. Brodin1, T. Ellingsen1, A. Soderbergh1, M. Rizk1, Å. Reckner1, P. Larsson1, L. Uhrenholt1, S. A. Just1, D. Stevens1, T. B. Laurberg1, G. Bakland1, R. Van Vollenhoven1 1Denmark, Finland, Iceland, Netherlands, Norway, Sweden Background: The optimal first-line treatment of patients (pts) with early rheumatoid arthritis (RA) is yet to be established. Objectives: The primary aim was to assess and compare the proportion of pts who achieved remission with active conventional therapy (ACT) and with three different biologic therapies after 24 wks. Secondary aims were to assess and compare other efficacy measures. Methods: The investigator-initiated NORD-STAR trial (NCT01491815) was conducted in the Nordic countries and Netherlands. In this multicenter, randomized, open-label, blinded-assessor study pts with treatment-naïve, early RA with DAS28>3.2, and positive RF or ACPA, or CRP >10mg/L were randomized 1:1:1:1. Methotrexate (25 mg/week after one month) was combined with: 1) (ACT): oral prednisolone (tapered quickly); or : sulphasalazine, hydroxychloroquine and mandatory intra-articular (IA) glucocorticoid (GC) injections in swollen joints

Published
2020

14. Scoring magnetic resonance imaging (MRI) inflammation and structural lesions in sacroiliac joints of patients with axial spondyloarthritis:assessment of all MRI slices of the cartilaginous compartment versus standardized six or five slices

Author

Krabbe, S., Kröber, G., Pedersen, S. J., Østergaard, M., Møller, J. M., Sørensen, I. J., Jensen, B., Madsen, O. R., Klarlund, M., Weber, U., Krabbe, S., Kröber, G., Pedersen, S. J., Østergaard, M., Møller, J. M., Sørensen, I. J., Jensen, B., Madsen, O. R., Klarlund, M., and Weber, U.

Abstract

Objectives: The Spondyloarthritis Research Consortium of Canada (SPARCC) sacroiliac joint (SIJ) scoring system assesses six or five (6/5) semicoronal magnetic resonance imaging (MRI) slices for inflammation/structural lesions in patients with axial spondyloarthritis (axSpA). However, the cartilaginous SIJ compartment may be visible in a few additional slices. The objective was to investigate interreader reliability, sensitivity to change, and classification of MRI scans as positive or negative for various lesion types using an ‘all slices’ approach versus standard SPARCC scoring of 6/5 slices. Method: Fifty-three axSpA patients were treated with the tumour necrosis factor inhibitor golimumab and followed with serial MRI scans at weeks 0, 4, 16, and 52. The most anterior and posterior slices covering the cartilaginous compartment and the transitional slice were identified. Scores for inflammation, fat metaplasia, erosion, backfill, and ankylosis in the cartilaginous SIJ compartment were calculated for the ‘all slices’ approach and the 6/5 slices standard. Results: By the ‘all slices’ approach, three readers scored mean 7.2, 7.7, and 7.0 slices per MRI scan. Baseline and change scores for the various lesion types closely correlated between the two approaches (Pearson’s rho ≥ 0.95). Inflammation score was median 13 (interquartile range 6–21, range 0–49) for 6/5 slices versus 14 (interquartile range 6–23, range 0–69) for all slices at baseline. Interreader reliability, sensitivity to change, and classification of MRI scans as positive or negative for various lesion types were similar. Conclusion: The standardized 6/5 slices approach showed no relevant differences from the ‘all slices’ approach and, therefore, is equally suited for monitoring purposes.

Published
2020

16. OP0018 A MULTICENTER RANDOMIZED STUDY IN EARLY RHEUMATOID ARTHRITIS TO COMPARE ACTIVE CONVENTIONAL THERAPY VERSUS THREE BIOLOGICAL TREATMENTS: 24 WEEK EFFICACY RESULTS OF THE NORD-STAR TRIAL

Author

Hetland, M. L., primary, Haavardsholm, E. A., additional, Rudin, A., additional, Nordström, D., additional, Nurmohamed, M., additional, Gudbjornsson, B., additional, Lampa, J., additional, Hørslev-Petersen, K., additional, Uhlig, T., additional, Gröndal, G., additional, Ǿstergaard, M., additional, Heiberg, M., additional, Twisk, J., additional, Krabbe, S., additional, Lend, K., additional, Olsen, I., additional, Lindqvist, J., additional, Ekwall, A. K. H., additional, Grøn, K. L., additional, Kapetanovic, M. C., additional, Faustini, F., additional, Tuompo, R., additional, Lorenzen, T., additional, Cagnotto, G., additional, Baecklund, E., additional, Hendricks, O., additional, Vedder, D., additional, Sokka-Isler, T., additional, Husmark, T., additional, Ljosa, M. K. A., additional, Brodin, E., additional, Ellingsen, T., additional, Soderbergh, A., additional, Rizk, M., additional, Reckner, Å., additional, Larsson, P., additional, Uhrenholt, L., additional, Just, S. A., additional, Stevens, D., additional, Laurberg, T. B., additional, Bakland, G., additional, and Van Vollenhoven, R., additional

Published
2020
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17. Scoring magnetic resonance imaging (MRI) inflammation and structural lesions in sacroiliac joints of patients with axial spondyloarthritis: assessment of all MRI slices of the cartilaginous compartment versus standardized six or five slices

Author

Krabbe, S, primary, Kröber, G, additional, Pedersen, SJ, additional, Østergaard, M, additional, Møller, JM, additional, Sørensen, IJ, additional, Jensen, B, additional, Madsen, OR, additional, Klarlund, M, additional, and Weber, U, additional

Published
2019
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18. Extremely poor patient-reported outcomes are associated with lack of clinical response and decreased retention rate of tumour necrosis factor inhibitor treatment in patients with axial spondyloarthritis

Author

Krabbe, S, Glintborg, B, Østergaard, M, Hetland, M L, Krabbe, S, Glintborg, B, Østergaard, M, and Hetland, M L

Abstract

OBJECTIVE: To investigate whether axial spondyloarthritis (axSpA) patients with extremely poor patient-reported outcomes (PROs) at start of first tumour necrosis factor inhibitor (TNFi) treatment have poorer treatment response and shorter treatment retention than other patients.METHOD: This observational cohort study was based on the nationwide DANBIO registry. Patients with axSpA who started first TNFi during 2011-2016 were stratified according to baseline Bath Ankylosing Spondylitis Disease Activity Index (BASDAI ≥ 0.0 to ≤ 4.0, > 4.0 to ≤ 5.0, > 5.0 to ≤ 6.0, > 6.0 to ≤ 7.0, > 7.0 to ≤ 8.0, > 8.0 to ≤ 9.0, and > 9.0 to ≤ 10.0). An extremely poor BASDAI was defined as BASDAI > 9.0 to ≤ 10.0. Treatment responses after 6 months [≥ 50% improvement from baseline BASDAI (BASDAI50), ≥ 40% improvement in Assessment of SpondyloArthritis international Society (ASAS40) response, and ASAS partial remission] in patients with extremely poor PROs were compared with other patients by chi-squared tests, and retention rates by log-rank tests. Similar analyses were done for Bath Ankylosing Spondylitis Functional Index (BASFI), pain score, and patient global score.RESULTS: The study included 1396 patients (median age 39 years, 60% men). Patients with extremely poor baseline BASDAI [63 patients (5%)] were more often women, ever smokers, and human leucocyte antigen-B27 negative, and had higher body mass index. Response rates were poorer in patients with extremely poor BASDAI vs remaining patients (BASDAI50 19% and 41%, respectively, p < 0.001; ASAS40 16% and 35%, p = 0.002; ASAS partial remission 6% and 22%, p < 0.001). Patients with extremely poor BASDAI had lower 1 year treatment retention (51% and 68%, p < 0.001). Largely similar results were found for patients with extremely poor BASFI, pain score, and patient global score.CONCLUSION: Patients who reported an unusually large symptom burden at baseline had poor response rates an

Published
2019

20. Can Sufficient Reliability of Scoring SIJ Sctructural Lesions on MRI be Achieved Using a Web-based Calibration Module Developed on Principles of Artificial Intelligence

Author

Maksymowych, W. P., Kroeber, G., Danebod, K., Weiss, P., Biko, D. M., Weber, U., Krabbe, S., Maksymowych, M. P., Cheah, J., Bird, P., Kogay, T., Jaremko, J., Zubler, V, Chauvin, N., Shafer, S., Heffernan, E., Guglielmi, R., Winn, N., Francavilla, M., Pedersen, S. J., Boutrup, H., Paschke, J., and Lambert, R. G.

Published
2018

21. Whole-body MRI in inflammatory arthritis - Systematic literature review and first steps towards standardization and an OMERACT scoring system

Author

Ostergaard, M, Eshed, I, Althoff, C, Poggenborg, R, Diekhoff, T, Krabbe, S, Weckbach, S, Lambert, R, Pedersen, S, Maksymowych, W, Peterfy, C, Freeston, J, Bird, P, Conaghan, P, and Hermann, K

Abstract

Objective: Whole-body magnetic resonance imaging (WB-MRI) is a relatively new technique that can enable assessment of the overall inflammatory status of people with arthritis, but standards for image acquisition, definitions of key pathologies, and a quantification system are required. Our aim was to perform a systematic literature review (SLR) and to develop consensus definitions of key pathologies, anatomical locations for assessment, a set of MRI sequences and imaging planes for the different body regions, and a preliminary scoring system for WB-MRI in inflammatory arthritis. Methods: An SLR was initially performed, searching for WB-MRI studies in arthritis, osteoarthritis, spondyloarthritis, or enthesitis. These results were presented to a meeting of the MRI in Arthritis Working Group together with an MR image review. Following this, preliminary standards for WB-MRI in inflammatory arthritides were developed with further iteration at the Working Group meetings at the Outcome Measures in Rheumatology (OMERACT) 2016. Results: The SLR identified 10 relevant original articles (7 cross-sectional and 3 longitudinal, mostly focusing on synovitis and/or enthesitis in spondyloarthritis, 4 with reproducibility data). The Working Group decided on inflammation in peripheral joints and entheses as primary focus areas, and then developed consensus MRI definitions for these pathologies, selected anatomical locations for assessment, agreed on a core set of MRI sequences and imaging planes for the different regions, and proposed a preliminary scoring system. It was decided to test and further develop the system by iterative multireader exercises. Conclusion: These first steps in developing an OMERACT WB-MRI scoring system for use in inflammatory arthritides offer a framework for further testing and refinement.

Published
2017

22. OP0038 Dose tapering and discontinuation of biological therapy in rheumatoid arthritis patients in remission in routine care – 2-year outcomes and identification of predictors

Author

Brahe, C.h., Krabbe, S., Østergaard, M., Ørnbjerg, L., Glinatsi, D., Røgind, H., Jensen, H.S., Hansen, A., Nørregaard, J., Jacobsen, S., Terslev, L., Huynh, T.k., Jensen, D.v., Manilo, N., Asmussen, K., Frandsen, P.b., Boesen, M., Rastiemadabadi, Z., Carlsen, L. M., Møller, J., Krogh, N.s., Hetland, M.l., Brahe, C.h., Krabbe, S., Østergaard, M., Ørnbjerg, L., Glinatsi, D., Røgind, H., Jensen, H.S., Hansen, A., Nørregaard, J., Jacobsen, S., Terslev, L., Huynh, T.k., Jensen, D.v., Manilo, N., Asmussen, K., Frandsen, P.b., Boesen, M., Rastiemadabadi, Z., Carlsen, L. M., Møller, J., Krogh, N.s., and Hetland, M.l.

Published
2018

23. Scoring magnetic resonance imaging (MRI) inflammation and structural lesions in sacroiliac joints of patients with axial spondyloarthritis: assessment of all MRI slices of the cartilaginous compartment versus standardized six or five slices.

Author

Krabbe, S, Kröber, G, Pedersen, SJ, Østergaard, M, Møller, JM, Sørensen, IJ, Jensen, B, Madsen, OR, Klarlund, M, Weber, U, Pedersen, S J, Møller, J M, Sørensen, I J, and Madsen, O R

Subjects
*SACROILIAC joint, *MAGNETIC resonance imaging, *INFLAMMATION, *DRUG therapy for arthritis, *THERAPEUTIC use of monoclonal antibodies, *ANKYLOSIS, *SPONDYLOARTHROPATHIES, *METAPLASIA, *ARTHRITIS, *BONE marrow, *RESEARCH bias, *ARTICULAR cartilage, *EDEMA, *ADIPOSE tissues
Abstract

Objectives: The Spondyloarthritis Research Consortium of Canada (SPARCC) sacroiliac joint (SIJ) scoring system assesses six or five (6/5) semicoronal magnetic resonance imaging (MRI) slices for inflammation/structural lesions in patients with axial spondyloarthritis (axSpA). However, the cartilaginous SIJ compartment may be visible in a few additional slices. The objective was to investigate interreader reliability, sensitivity to change, and classification of MRI scans as positive or negative for various lesion types using an 'all slices' approach versus standard SPARCC scoring of 6/5 slices.Method: Fifty-three axSpA patients were treated with the tumour necrosis factor inhibitor golimumab and followed with serial MRI scans at weeks 0, 4, 16, and 52. The most anterior and posterior slices covering the cartilaginous compartment and the transitional slice were identified. Scores for inflammation, fat metaplasia, erosion, backfill, and ankylosis in the cartilaginous SIJ compartment were calculated for the 'all slices' approach and the 6/5 slices standard.Results: By the 'all slices' approach, three readers scored mean 7.2, 7.7, and 7.0 slices per MRI scan. Baseline and change scores for the various lesion types closely correlated between the two approaches (Pearson's rho ≥ 0.95). Inflammation score was median 13 (interquartile range 6-21, range 0-49) for 6/5 slices versus 14 (interquartile range 6-23, range 0-69) for all slices at baseline. Interreader reliability, sensitivity to change, and classification of MRI scans as positive or negative for various lesion types were similar.Conclusion: The standardized 6/5 slices approach showed no relevant differences from the 'all slices' approach and, therefore, is equally suited for monitoring purposes. [ABSTRACT FROM AUTHOR]

Published
2020
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25. FRI0591 Whole-body mri demonstrates reduction of inflammation in peripheral joints and entheses during tnf-inhibitor treatment in patients with axial spondyloarthritis, but also age-dependent persistent inflammation in joints prone to osteoarthritis

Author

Krabbe, S., primary, Østergaard, M., additional, Eshed, I., additional, Sørensen, I.J., additional, Møller, J., additional, Jensen, B., additional, Madsen, O.R., additional, Klarlund, M., additional, and Pedersen, S.J., additional

Published
2018
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28. OP0038 Dose tapering and discontinuation of biological therapy in rheumatoid arthritis patients in remission in routine care – 2-year outcomes and identification of predictors

Author

Brahe, C.H., primary, Krabbe, S., additional, Østergaard, M., additional, Ørnbjerg, L., additional, Glinatsi, D., additional, Røgind, H., additional, Jensen, H.S., additional, Hansen, A., additional, Nørregaard, J., additional, Jacobsen, S., additional, Terslev, L., additional, Huynh, T.K., additional, Jensen, D.V., additional, Manilo, N., additional, Asmussen, K., additional, Frandsen, P.B., additional, Boesen, M., additional, Rastiemadabadi, Z., additional, Carlsen, L.M., additional, Møller, J., additional, Krogh, N.S., additional, and Hetland, M.L., additional

Published
2018
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30. FRI0597 Validation of web-based calibration modules for imaging scoring systems based on principles of artificial intelligence: the sparcc mri sacroiliac joint inflammation score

Author

Maksymowych, W.P., primary, Krabbe, S., additional, Biko, D., additional, Weiss, P., additional, Maksymowych, M.P., additional, Cheah, J., additional, Kröber, G., additional, Weber, U., additional, Danebod, K., additional, Bird, P., additional, Chiowchanwisawakit, P., additional, Moeller, J., additional, Francavilla, M., additional, Stimec, J., additional, Kogay, T., additional, Zubler, V., additional, Battish, M., additional, Winn, N., additional, Rumsey, D., additional, Guglielmi, R., additional, Pedersen, S.J., additional, Boutrup, H., additional, Shafer, S., additional, Jaremko, J., additional, Malik, F., additional, Heffernan, E., additional, Johansson, M.P., additional, Trinh, B., additional, Paschke, J., additional, and Lambert, R.G., additional

Published
2018
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32. VALIDATION OF A MODIFIED NEW YORK CRITERIA RETIC E-TOOL FOR INCREASING SCORING PROFICIENCY OF RADIOGRAPHS OF THE SACROILIAC JOINTS IN AXIAL SPONDYLOARTHRITIS.

Author

Hadsbjerg, A. E. F., Østergaard, M., Paschke, J., Micheroli, R., Pedersen, S. J., Ciurea, A., Nissen, M. J., Bubova, K., Wichuk, S., De Hooge, M., Krabbe, S., Mathew, A. J., Gregová, M., Wetterslev, M., Gorican, K., Pintaric, K., Snoj, Z., Moeller, B., Bernatschek, A., and Donzallaz, M.

Published
2023
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36. Investigation of a multi-biomarker disease activity score in rheumatoid arthritis by comparison with magnetic resonance imaging, computed tomography, ultrasonography, and radiography parameters of inflammation and damage

Author

Krabbe, S., Bolce, R., Brahe Pedersen, C., Døhn, U. M., Ejbjerg, B., Hetland, M., Sasso, E., Chernoff, D., Hansen, M. S., Knudsen, L., Hansen, A., Madsen, O. R., Hasselquist, M., Møller, J., Østergaard, M., Krabbe, S., Bolce, R., Brahe Pedersen, C., Døhn, U. M., Ejbjerg, B., Hetland, M., Sasso, E., Chernoff, D., Hansen, M. S., Knudsen, L., Hansen, A., Madsen, O. R., Hasselquist, M., Møller, J., and Østergaard, M.

Abstract

Objectives: To investigate the multi-biomarker disease activity (MBDA) score by comparison with imaging findings in an investigator-initiated rheumatoid arthritis (RA) trial (HURRAH trial, NCT00696059). Method: Fifty-two patients with established RA initiated adalimumab treatment and had magnetic resonance imaging (MRI), ultrasonography (US), computed tomography (CT), and radiography performed at weeks 0, 26, and 52. Serum samples were analysed using MBDA score assays and associations between clinical measures, MBDA score, and imaging findings were investigated. Results: The MBDA score correlated significantly with MRI synovitis (rho = 0.65, p < 0.001), MRI bone marrow oedema (rho = 0.36, p = 0.044), and US power Doppler (PD) score at week 26 (rho = 0.35, p = 0.039) but not at week 0 or week 52. In the 15 patients who had achieved a Disease Activity Score based on C-reactive protein (DAS28-CRP) < 2.6 at week 26, MRI and/or US detected subclinical inflammation and 13 (87%) had a moderate/high MBDA score. For the cohort with available data, none of the four patients in MBDA remission (score ≤ 25) at week 26 had progression of imaging damage from baseline to week 52 whereas progression was observed in three out of nine (33%) and seven out of 21 (33%) patients with moderate (30–44) and high (> 44) MBDA scores, respectively. Conclusions: In this cohort, the MBDA score correlated poorly with MRI/US inflammation. However, the MBDA score and MRI/US were generally concordant in showing signs of inflammation in most patients in clinical remission during anti-tumour necrosis factor (anti-TNF) therapy. MBDA scores were elevated in all patients with structural damage progression.

Published
2017

40. Responsiveness of A New MRI Scoring Method Based on The Canada-Denmark Definitions of Lesions in The Spine and The SPARCC MRI Spine Inflammation Index in Patients with Axial Spondyloarthritis

Author

Krabbe, S., Østergaard, M., Sørensen, I. J., Jensen, B., Møller, J., Balding, L., Madsen, O. R., Asmussen, K. H., Eng, G. P., Pedersen, S. J., Krabbe, S., Østergaard, M., Sørensen, I. J., Jensen, B., Møller, J., Balding, L., Madsen, O. R., Asmussen, K. H., Eng, G. P., and Pedersen, S. J.

Published
2016

41. The Anatomical Distribution of Inflammation, Fat, Erosion and New Bone Formation in The Spine Assessed According To The Canada-Denmark MRI Definitions in Patients with Axial Spondyloarthritis

Author

Krabbe, S., Østergaard, M., Sørensen, I. J., Jensen, B., Madsen, O. R., Eng, G. P., Asmussen, K. H., Møller, J., Balding, L., Pedersen, S. J., Krabbe, S., Østergaard, M., Sørensen, I. J., Jensen, B., Madsen, O. R., Eng, G. P., Asmussen, K. H., Møller, J., Balding, L., and Pedersen, S. J.

Published
2016

42. AB0263 Agreement between Das28, Acr/eular, Sdai, Cdai and Ultrasound Remission in Patients with Rheumatoid Arthritis Receiving Biological Treatment in Routine Care

Author

Brahe, C H, Terslev, L, Krabbe, S, ?stergaard, M., R?gind, H., Jensen, H S, Hansen, A, Nørregaard, J, Jacobsen, S, Ellegaard, K, Fana, V, Juul, L, Huynh, T, Jensen, D, Manilo, N, Asmussen, K, Frandsen, P B, Pedersen, S T, Krogh, N S, Hetland, M L, Brahe, C H, Terslev, L, Krabbe, S, ?stergaard, M., R?gind, H., Jensen, H S, Hansen, A, Nørregaard, J, Jacobsen, S, Ellegaard, K, Fana, V, Juul, L, Huynh, T, Jensen, D, Manilo, N, Asmussen, K, Frandsen, P B, Pedersen, S T, Krogh, N S, and Hetland, M L

Published
2016

45. Investigation of a multi-biomarker disease activity score in rheumatoid arthritis by comparison with magnetic resonance imaging, computed tomography, ultrasonography, and radiography parameters of inflammation and damage

Author

Krabbe, S, primary, Bolce, R, additional, Brahe, CH, additional, Døhn, UM, additional, Ejbjerg, BJ, additional, Hetland, ML, additional, Sasso, EH, additional, Chernoff, D, additional, Hansen, MS, additional, Knudsen, LS, additional, Hansen, A, additional, Madsen, OR, additional, Hasselquist, M, additional, Møller, J, additional, and Østergaard, M, additional

Published
2016
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48. AB0263 Agreement between Das28, Acr/eular, Sdai, Cdai and Ultrasound Remission in Patients with Rheumatoid Arthritis Receiving Biological Treatment in Routine Care

Author

Brahe, C.H., primary, Terslev, L., additional, Krabbe, S., additional, Østergaard, M., additional, Røgind, H., additional, Jensen, H.S., additional, Hansen, A., additional, Nørregaard, J., additional, Jacobsen, S., additional, Ellegaard, K., additional, Fana, V., additional, Juul, L., additional, Huynh, T., additional, Jensen, D., additional, Manilo, N., additional, Asmussen, K., additional, Frandsen, P.B., additional, Pedersen, S.T., additional, Krogh, N.S., additional, and Hetland, M.L., additional

Published
2016
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49. SAT0559 The Anatomical Distribution of Inflammation, Fat, Erosion and New Bone Formation in The Spine Assessed According To The Canada-Denmark MRI Definitions in Patients with Axial Spondyloarthritis: Table 1.

Author

Krabbe, S., primary, Østergaard, M., additional, Sørensen, I.J., additional, Jensen, B., additional, Madsen, O.R., additional, Eng, G.P., additional, Asmussen, K.H., additional, Møller, J., additional, Balding, L., additional, and Pedersen, S.J., additional

Published
2016
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50. FRI0548 Responsiveness of A New MRI Scoring Method Based on The Canada-Denmark Definitions of Lesions in The Spine and The SPARCC MRI Spine Inflammation Index in Patients with Axial Spondyloarthritis: Table 1.

Author

Krabbe, S., primary, Østergaard, M., additional, Sørensen, I.J., additional, Jensen, B., additional, Møller, J., additional, Balding, L., additional, Madsen, O.R., additional, Asmussen, K.H., additional, Eng, G.P., additional, and Pedersen, S.J., additional

Published
2016
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