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477 results on '"Krönke, Martin"'

1. Tuberculosis in otherwise healthy adults with inherited TNF deficiency

Author

Arias, Andrés A., Neehus, Anna-Lena, Ogishi, Masato, Meynier, Vincent, Krebs, Adam, Lazarov, Tomi, Lee, Angela M., Arango-Franco, Carlos A., Yang, Rui, Orrego, Julio, Corcini Berndt, Melissa, Rojas, Julian, Li, Hailun, Rinchai, Darawan, Erazo-Borrás, Lucia, Han, Ji Eun, Pillay, Bethany, Ponsin, Khoren, Chaldebas, Matthieu, Philippot, Quentin, Bohlen, Jonathan, Rosain, Jérémie, Le Voyer, Tom, Janotte, Till, Amarajeeva, Krishnajina, Soudée, Camille, Brollo, Marion, Wiegmann, Katja, Marquant, Quentin, Seeleuthner, Yoann, Lee, Danyel, Lainé, Candice, Kloos, Doreen, Bailey, Rasheed, Bastard, Paul, Keating, Narelle, Rapaport, Franck, Khan, Taushif, Moncada-Vélez, Marcela, Carmona, María Camila, Obando, Catalina, Alvarez, Jesús, Cataño, Juan Carlos, Martínez-Rosado, Larry Luber, Sanchez, Juan P., Tejada-Giraldo, Manuela, L’Honneur, Anne-Sophie, Agudelo, María L., Perez-Zapata, Lizet J., Arboleda, Diana M., Alzate, Juan Fernando, Cabarcas, Felipe, Zuluaga, Alejandra, Pelham, Simon J., Ensser, Armin, Schmidt, Monika, Velásquez-Lopera, Margarita M., Jouanguy, Emmanuelle, Puel, Anne, Krönke, Martin, Ghirardello, Stefano, Borghesi, Alessandro, Pahari, Susanta, Boisson, Bertrand, Pittaluga, Stefania, Ma, Cindy S., Emile, Jean-François, Notarangelo, Luigi D., Tangye, Stuart G., Marr, Nico, Lachmann, Nico, Salvator, Hélène, Schlesinger, Larry S., Zhang, Peng, Glickman, Michael S., Nathan, Carl F., Geissmann, Frédéric, Abel, Laurent, Franco, José Luis, Bustamante, Jacinta, Casanova, Jean-Laurent, and Boisson-Dupuis, Stéphanie

Published
2024
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7. T Lymphoid Differentiation in Human Bone Marrow

Author

Klein, Florian, Feldhahn, Niklas, Lee, Sanggyu, Wang, Hui, Ciuffi, Fiammetta, von Elstermann, Mirko, Toribio, María L., Sauer, Heinrich, Wartenberg, Maria, Barath, Varun Singh, Krönke, Martin, Wernet, Peter, Rowley, Janet D., and Müschen, Markus

Published
2003

8. Molecular Portraits of B Cell Lineage Commitment

Author

Müschen, Markus, Lee, Sanggyu, Zhou, Guolin, Feldhahn, Niklas, Barath, Varun Singh, Chen, Jianjun, Moers, Cordula, Krönke, Martin, Rowley, Janet D., and Wang, San Ming

Published
2002

10. Development of an immunochromatographic lateral flow assay to rapidly detect OXA-23-, OXA-40-, OXA-58- and NDM-mediated carbapenem resistance determinants in Acinetobacter baumannii

Author

Mertins, Sonja, primary, Higgins, Paul G., additional, Thunissen, Caroline, additional, Magein, Henri, additional, Gilleman, Quentin, additional, Mertens, Pascal, additional, Rodríguez, María González, additional, Maus, Liza Marie, additional, Seifert, Harald, additional, Krönke, Martin, additional, and Klimka, Alexander, additional

Published
2023
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14. Volitional Dysfunction in Self-control Failures and Addictive Behaviours

Author

Goschke, Thomas, Smolka, Michael, Bühringer, Gerhard, Fröhner, Juliane, Kräplin, Anja, Krönke, Martin, and Wolff, Max

Subjects
FOS: Psychology, self-control, substance use disorders, addictive disorders, Psychology, behavioral addictions, cognitive control, impulsive decision-making, error monitoring, Social and Behavioral Sciences, executive functioning
Abstract

Failures of self-control during conflicts between long-term goals and immediate desires are a key characteristic of many harmful behaviours, including unhealthy eating habits, lack of exercise and problematic substance use, which often have adverse personal consequences and incur great societal costs. The project aims to elucidate neurocognitive mechanisms mediating deficient self-control, both in daily self-control failures and in substance use disorders and behavioural addictions, which are characterized by a loss of control despite awareness of adverse consequences. We launched a prospective cohort study using a multi-level approach that combines (i) a comprehensive clinical assessment, (ii) behavioural task batteries assessing cognitive control and decision-making functions, (iii) task-related and resting state fMRI, and (iv) smartphone-based ecological momentary assessment of daily self-control failures. From a representative community sample, we recruited three groups of participants (n = 338; age 19 – 27 years) with (a) symptoms of non-substance related (n=118) and (b) substance-related addictive disorders (n=100) and (c) syndrome-free controls (n=120. Participants are invited to yearly clinical follow-up assessments and further multi-level assessments 3 and 6 years after initial recruitment. Results obtained so far (until 09/2021) provide converging evidence that task performance as well as brain activity in monitoring, control, and valuation networks is reliably associated with the propensity to commit real-life self-control failures. Results support a process model, according to which deficient performance-monitoring leads to an insufficient recruitment of control networks, which attenuates the impact of long-term goals on neural value signals and increases the likelihood of self-control failures. In the final funding period (until 06/2024), we will extend the clinical follow-up period to 7 years. In addition, we will assess stress markers as possible moderators of self-control. With our cross-lagged panel design we expect the project to make a substantial contribution to the central unresolved question whether dysfunctions of cognitive control are causally involved in the development and trajectories of self-control failures and addictive behaviours, as well as to the disputed question of communalities and differences between different addictive disorders. Thereby, we hope to contribute to mechanism-based models of self-control impairments as a foundation for improved prevention and therapy.

Published
2022
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15. Hypothesis C1: Cross-lagged association between daily self-control failures and addictive behaviour

Author

Kräplin, Anja, Joshanloo, Mohsen, Fröhner, Juliane, Krönke, Martin, Wolff, Max, Smolka, Michael, Goschke, Thomas, and Bühringer, Gerhard

Subjects
addictive behaviour, self-control, substance use disorder, Medicine and Health Sciences, Life Sciences, Psychiatry and Psychology, behavioural addiction, cognitive control
Abstract

Please note that this is a detailed description of a part of the hypotheses from the project ‘Volitional Dysfunction in Self-control Failures and Addictive Behaviours’, which you can find on OSF at https://osf.io/rhjb4. As we have various hypotheses with complex operationalisations in this project, we planned to present separate analysis plans for each hypothesis. The separate analysis plans are and will be added to the main OSF project and numbered according to the hypotheses under section ‘4 Hypotheses’ in the main document ‘OSF Registration C1_23.09.21’.

Published
2022
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17. Ceramide as an Activator Lipid of Cathepsin D

Author

Heinrich, Michael, Wickel, Marc, Winoto-Morbach, Supandi, Schneider-Brachert, Wulf, Weber, Thomas, Brunner, Josef, Saftig, Paul, Peters, Christoph, Krönke, Martin, Schütze, Stefan, Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Langner, Jürgen, editor, and Ansorge, Siegfried, editor

Published
2002
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20. BID‐dependent release of mitochondrial SMAC dampens XIAP‐mediated immunity against Shigella

Author

Andree, Maria, Seeger, Jens M, Schüll, Stephan, Coutelle, Oliver, Wagner‐Stippich, Diana, Wiegmann, Katja, Wunderlich, Claudia M, Brinkmann, Kerstin, Broxtermann, Pia, Witt, Axel, Fritsch, Melanie, Martinelli, Paola, Bielig, Harald, Lamkemeyer, Tobias, Rugarli, Elena I, Kaufmann, Thomas, Sterner‐Kock, Anja, Wunderlich, F Thomas, Villunger, Andreas, Martins, L Miguel, Krönke, Martin, Kufer, Thomas A, Utermöhlen, Olaf, and Kashkar, Hamid

Published
2014
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34. Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes

Author

Lampl, Sandra, primary, Janas, Marianne K., additional, Donakonda, Sainitin, additional, Brugger, Marcus, additional, Lohr, Kerstin, additional, Schneider, Annika, additional, Manske, Katrin, additional, Sperl, Laura E., additional, Kläger, Susan, additional, Küster, Bernhard, additional, Wettmarshausen, Jennifer, additional, Müller, Constanze, additional, Laschinger, Melanie, additional, Hartmann, Daniel, additional, Hüser, Norber, additional, Perocchi, Fabiana, additional, Schmitt-Kopplin, Philippe, additional, Hagn, Franz, additional, Zender, Lars, additional, Hornung, Veit, additional, Borner, Christoph, additional, Pichlmair, Andreas, additional, Kashkar, Hamid, additional, Klingenspor, Martin, additional, Prinz, Marco, additional, Schreiner, Sabrina, additional, Conrad, Marcus, additional, Jost, Philipp J., additional, Zischka, Hans, additional, Steiger, Katja, additional, Krönke, Martin, additional, Zehn, Dietmar, additional, Protzer, Ulrike, additional, Heikenwälder, Mathias, additional, Knolle, Percy A., additional, and Wohlleber, Dirk, additional

Published
2020
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36. Macrophages target Listeria monocytogenes by two discrete non-canonical autophagy pathways.

Author

Gluschko, Alexander, Farid, Alina, Herb, Marc, Grumme, Daniela, Krönke, Martin, and Schramm, Michael

Subjects
LISTERIA monocytogenes, TUMOR necrosis factors, AUTOPHAGY, PERITONEAL macrophages, CALCIUM channels, MACROPHAGES, PROTEIN kinase C, TOXINS
Abstract

Non-canonical autophagy pathways decorate single-membrane vesicles with Atg8-family proteins such as MAP1LC3/LC3 (microtubule-associated protein 1 light chain 3). Phagosomes containing the bacterial pathogen Listeria monocytogenes (L.m.) can be targeted by a non-canonical autophagy pathway called LC3-associated phagocytosis (LAP), which substantially contributes to the anti-listerial activity of macrophages and immunity. We here characterized a second non-canonical autophagy pathway targeting L.m.-containing phagosomes, which is induced by damage caused to the phagosomal membrane by the pore-forming toxin of L.m., listeriolysin O. This pore-forming toxin-induced non-canonical autophagy pathway (PINCA) was the only autophagic pathway evoked in tissue macrophages deficient for the NADPH oxidase CYBB/NOX2 that produces the reactive oxygen species (ROS) that are required for LAP induction. Similarly, also bone marrow-derived macrophages (BMDM) exclusively targeted L.m. by PINCA as they completely failed to induce LAP because of insufficient production of ROS through CYBB, in part, due to low expression of some CYBB complex subunits. Priming of BMDM with proinflammatory cytokines such as TNF and IFNG/IFNγ increased ROS production by CYBB and endowed them with the ability to target L.m. by LAP. Targeting of L.m. by LAP remained relatively rare, though, preventing LAP from substantially contributing to the anti-listerial activity of BMDM. Similar to LAP, the targeting of L.m.-containing phagosomes by PINCA promoted their fusion with lysosomes. Surprisingly, however, this did not substantially contribute to anti-listerial activity of BMDM. Thus, in contrast to LAP, PINCA does not have clear anti-listerial function suggesting that the two different non-canonical autophagy pathways targeting L.m. may have discrete functions. Abbreviations: actA/ActA: actin assembly-inducing protein A; ATG: autophagy-related; BMDM: Bone marrow-derived macrophages; CALCOCO2/NDP52: calcium-binding and coiled-coil domain-containing protein 2; CYBA/p22phox: cytochrome b-245 light chain; CYBB/NOX2: cytochrome b(558) subunit beta; E. coli: Escherichia coli; IFNG/IFNγ: interferon gamma; L.m.: Listeria monocytogenes; LAP: LC3-associated phagocytosis; LGALS: galectin; LLO: listeriolysin O; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; NCF1/p47phox: neutrophil cytosol factor 1; NCF2/p67phox: neutrophil cytosol factor 2; NCF4/p67phox: neutrophil cytosol factor 4; Peritoneal macrophages: PM; PINCA: pore-forming toxin-induced non-canonical autophagy; plc/PLC: 1-phosphatidylinositol phosphodiesterase; PMA: phorbol 12-myristate 13-acetate; RB1CC1/FIP200: RB1-inducible coiled-coil protein 1; ROS: reactive oxygen species; S. aureus: Staphylococcus aureus; S. flexneri: Shigella flexneri; SQSTM1/p62: sequestosome 1; S. typhimurium: Salmonella typhimurium; T3SS: type III secretion system; TNF: tumor necrosis factor; ULK: unc-51 like autophagy activating kinase; PM: peritoneal macrophages; WT: wild type. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Ceramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation

Author

El-Hindi, Khadija, primary, Brachtendorf, Sebastian, additional, Hartel, Jennifer Christina, additional, Oertel, Stephanie, additional, Birod, Kerstin, additional, Trautmann, Sandra, additional, Thomas, Dominique, additional, Ulshöfer, Thomas, additional, Weigert, Andreas, additional, Utermöhlen, Olaf, additional, Krönke, Martin, additional, and Grösch, Sabine, additional

Published
2020
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42. Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide

Author

Günther, Saskia D., primary, Fritsch, Melanie, additional, Seeger, Jens M., additional, Schiffmann, Lars M., additional, Snipas, Scott J., additional, Coutelle, Maria, additional, Kufer, Thomas A., additional, Higgins, Paul G., additional, Hornung, Veit, additional, Bernardini, Maria L., additional, Höning, Stefan, additional, Krönke, Martin, additional, Salvesen, Guy S., additional, and Kashkar, Hamid, additional

Published
2019
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50. Macrophages target Listeria monocytogenesby two discrete non-canonical autophagy pathways

Author

Gluschko, Alexander, Farid, Alina, Herb, Marc, Grumme, Daniela, Krönke, Martin, and Schramm, Michael

Abstract

ABSTRACTNon-canonical autophagy pathways decorate single-membrane vesicles with Atg8-family proteins such as MAP1LC3/LC3 (microtubule-associated protein 1 light chain 3). Phagosomes containing the bacterial pathogen Listeria monocytogenes(L.m.) can be targeted by a non-canonical autophagy pathway called LC3-associated phagocytosis (LAP), which substantially contributes to the anti-listerial activity of macrophages and immunity. We here characterized a second non-canonical autophagy pathway targeting L.m.-containing phagosomes, which is induced by damage caused to the phagosomal membrane by the pore-forming toxin of L.m., listeriolysin O. This pore-forming toxin-induced non-canonical autophagy pathway (PINCA) was the only autophagic pathway evoked in tissue macrophages deficient for the NADPH oxidase CYBB/NOX2 that produces the reactive oxygen species (ROS) that are required for LAP induction. Similarly, also bone marrow-derived macrophages (BMDM) exclusively targeted L.m. by PINCA as they completely failed to induce LAP because of insufficient production of ROS through CYBB, in part, due to low expression of some CYBB complex subunits. Priming of BMDM with proinflammatory cytokines such as TNF and IFNG/IFNγ increased ROS production by CYBB and endowed them with the ability to target L.m. by LAP. Targeting of L.m. by LAP remained relatively rare, though, preventing LAP from substantially contributing to the anti-listerial activity of BMDM. Similar to LAP, the targeting of L.m.-containing phagosomes by PINCA promoted their fusion with lysosomes. Surprisingly, however, this did not substantially contribute to anti-listerial activity of BMDM. Thus, in contrast to LAP, PINCA does not have clear anti-listerial function suggesting that the two different non-canonical autophagy pathways targeting L.m. may have discrete functions.Abbreviations: actA/ActA: actin assembly-inducing protein A; ATG: autophagy-related; BMDM: Bone marrow-derived macrophages; CALCOCO2/NDP52: calcium-binding and coiled-coil domain-containing protein 2; CYBA/p22phox: cytochrome b-245 light chain; CYBB/NOX2: cytochrome b(558) subunit beta; E. coli: Escherichia coli; IFNG/IFNγ: interferon gamma; L.m.: Listeria monocytogenes; LAP: LC3-associated phagocytosis; LGALS: galectin; LLO: listeriolysin O; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; NCF1/p47phox: neutrophil cytosol factor 1; NCF2/p67phox: neutrophil cytosol factor 2; NCF4/p67phox: neutrophil cytosol factor 4; Peritoneal macrophages: PM; PINCA: pore-forming toxin-induced non-canonical autophagy; plc/PLC: 1-phosphatidylinositol phosphodiesterase; PMA: phorbol 12-myristate 13-acetate; RB1CC1/FIP200: RB1-inducible coiled-coil protein 1; ROS: reactive oxygen species; S. aureus: Staphylococcus aureus; S. flexneri: Shigella flexneri; SQSTM1/p62: sequestosome 1; S. typhimurium: Salmonella typhimurium; T3SS: type III secretion system; TNF: tumor necrosis factor; ULK: unc-51 like autophagy activating kinase; PM: peritoneal macrophages; WT: wild type.

Published
2022
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