Search

Your search keyword '"Kozyrskyj, Anita L"' showing total 660 results
Start Over Author "Kozyrskyj, Anita L"
660 results on '"Kozyrskyj, Anita L"'

6. The Milk Metabolome of Non-secretor and Lewis Negative Mothers

Author

Wang, Aidong, Koleva, Petya, du Toit, Elloise, Geddes, Donna T, Munblit, Daniel, Prescott, Susan L, Eggesbø, Merete, Johnson, Christine C, Wegienka, Ganesa, Shimojo, Naoki, Campbell, Dianne, Kozyrskyj, Anita L, and Slupsky, Carolyn M

Subjects
Medical Biochemistry and Metabolomics, Biomedical and Clinical Sciences, Clinical Research, Nutrition, Pediatric, human milk, metabolome, Lewis negative, oligosaccharide, energy metabolism, South Africa, non-secretor, Agricultural Biotechnology, Nutrition and Dietetics, Nutrition and dietetics
Abstract

Introduction: The functional role of milk for the developing neonate is an area of great interest, and a significant amount of research has been done. However, a lot of work remains to fully understand the complexities of milk, and the variations imposed through genetics. It has previously been shown that both secretor (Se) and Lewis blood type (Le) status impacts the human milk oligosaccharide (HMO) content of human milk. While some studies have compared the non-HMO milk metabolome of Se+ and Se- women, none have reported on the non-HMO milk metabolome of Se- and Le- mothers. Method and Results: To determine the differences in the non-HMO milk metabolome between Se-Le- mothers and other HMO phenotypes (Se+Le+, Se+Le-, and Se-Le+), 10 milk samples from 10 lactating mothers were analyzed using nuclear magnetic resonance (NMR) spectroscopy. Se or Le HMO phenotypes were assigned based on the presence and absence of 6 HMOs generated by the Se and Le genes. After classification, 58 milk metabolites were compared among the HMO phenotypes. Principal component analysis (PCA) identified clear separation between Se-Le- milk and the other milks. Fold change analysis demonstrated that the Se-Le- milk had major differences in free fatty acids, free amino acids, and metabolites related to energy metabolism. Conclusion: The results of this brief research report suggest that the milk metabolome of mothers with the Se-Le- phenotype differs in its non-HMO metabolite composition from mothers with other HMO phenotypes.

Published
2021

7. The Milk Metabolome of Non-secretor and Lewis Negative Mothers.

Author

Wang, Aidong, Koleva, Petya, du Toit, Elloise, Geddes, Donna T, Munblit, Daniel, Prescott, Susan L, Eggesbø, Merete, Johnson, Christine C, Wegienka, Ganesa, Shimojo, Naoki, Campbell, Dianne, Kozyrskyj, Anita L, and Slupsky, Carolyn M

Subjects
Lewis negative, South Africa, energy metabolism, human milk, metabolome, non-secretor, oligosaccharide, Agricultural Biotechnology, Nutrition and Dietetics
Abstract

Introduction: The functional role of milk for the developing neonate is an area of great interest, and a significant amount of research has been done. However, a lot of work remains to fully understand the complexities of milk, and the variations imposed through genetics. It has previously been shown that both secretor (Se) and Lewis blood type (Le) status impacts the human milk oligosaccharide (HMO) content of human milk. While some studies have compared the non-HMO milk metabolome of Se+ and Se- women, none have reported on the non-HMO milk metabolome of Se- and Le- mothers. Method and Results: To determine the differences in the non-HMO milk metabolome between Se-Le- mothers and other HMO phenotypes (Se+Le+, Se+Le-, and Se-Le+), 10 milk samples from 10 lactating mothers were analyzed using nuclear magnetic resonance (NMR) spectroscopy. Se or Le HMO phenotypes were assigned based on the presence and absence of 6 HMOs generated by the Se and Le genes. After classification, 58 milk metabolites were compared among the HMO phenotypes. Principal component analysis (PCA) identified clear separation between Se-Le- milk and the other milks. Fold change analysis demonstrated that the Se-Le- milk had major differences in free fatty acids, free amino acids, and metabolites related to energy metabolism. Conclusion: The results of this brief research report suggest that the milk metabolome of mothers with the Se-Le- phenotype differs in its non-HMO metabolite composition from mothers with other HMO phenotypes.

Published
2020

10. Longitudinal body mass index trajectories at preschool age: children with rapid growth have differential composition of the gut microbiota in the first year of life

Author

Reyna, Myrtha E., Petersen, Charisse, Dai, Darlene L. Y., Dai, Ruixue, Becker, Allan B., Azad, Meghan B., Miliku, Kozeta, Lefebvre, Diana L., Moraes, Theo J., Mandhane, Piushkumar J., Boutin, Rozlyn C. T., Finlay, B. Brett, Simons, Elinor, Kozyrskyj, Anita L., Lou, Wendy, Turvey, Stuart E., and Subbarao, Padmaja

Published
2022
Full Text
View/download PDF

11. Antibiotics within first year are linked to infant gut microbiome disruption and elevated atopic dermatitis risk

Author

Hoskinson, Courtney, primary, Medeleanu, Maria V., additional, Reyna, Myrtha E., additional, Dai, Darlene LY., additional, Chowdhury, Biswajit, additional, Moraes, Theo J., additional, Mandhane, Piushkumar J., additional, Simons, Elinor, additional, Kozyrskyj, Anita L., additional, Azad, Meghan B., additional, Petersen, Charisse, additional, Turvey, Stuart E., additional, and Subbarao, Padmaja, additional

Published
2024
Full Text
View/download PDF

14. Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations.

Author

Ho, Nhan T, Li, Fan, Lee-Sarwar, Kathleen A, Tun, Hein M, Brown, Bryan P, Pannaraj, Pia S, Bender, Jeffrey M, Azad, Meghan B, Thompson, Amanda L, Weiss, Scott T, Azcarate-Peril, M Andrea, Litonjua, Augusto A, Kozyrskyj, Anita L, Jaspan, Heather B, Aldrovandi, Grace M, and Kuhn, Louise

Subjects
Humans, Diarrhea, Biodiversity, Breast Feeding, Child, Preschool, Infant, Female, Dysbiosis, Gastrointestinal Microbiome, Nutrition, Infant Mortality, Pediatric, Emerging Infectious Diseases, Child, Preschool
Abstract

Previous studies on the differences in gut microbiota between exclusively breastfed (EBF) and non-EBF infants have provided highly variable results. Here we perform a meta-analysis of seven microbiome studies (1825 stool samples from 684 infants) to compare the gut microbiota of non-EBF and EBF infants across populations. In the first 6 months of life, gut bacterial diversity, microbiota age, relative abundances of Bacteroidetes and Firmicutes, and predicted microbial pathways related to carbohydrate metabolism are consistently higher in non-EBF than in EBF infants, whereas relative abundances of pathways related to lipid metabolism, vitamin metabolism, and detoxification are lower. Variation in predicted microbial pathways associated with non-EBF infants is larger among infants born by Caesarian section than among those vaginally delivered. Longer duration of exclusive breastfeeding is associated with reduced diarrhea-related gut microbiota dysbiosis. Furthermore, differences in gut microbiota between EBF and non-EBF infants persist after 6 months of age. Our findings elucidate some mechanisms of short and long-term benefits of exclusive breastfeeding across different populations.

Published
2018

15. Worldwide Variation in Human Milk Metabolome: Indicators of Breast Physiology and Maternal Lifestyle?

Author

Gay, Melvin CL, Koleva, Petya T, Slupsky, Carolyn M, Toit, Elloise du, Eggesbo, Merete, Johnson, Christine C, Wegienka, Ganesa, Shimojo, Naoki, Campbell, Dianne E, Prescott, Susan L, Munblit, Daniel, Geddes, Donna T, Kozyrskyj, Anita L, and InVIVO LactoActive Study Investigators

Subjects
InVIVO LactoActive Study Investigators, Breast, Milk, Human, Humans, Hypersensitivity, Choline, Carbohydrates, Amino Acids, Milk Proteins, Magnetic Resonance Spectroscopy, Mothers, Life Style, Energy Metabolism, Continental Population Groups, Ethnic Groups, United States, Japan, Australia, Norway, Female, Male, Metabolome, human milk, lactation, milk metabolites, milk metabolomics, Milk, Human, Food Sciences, Nutrition and Dietetics
Abstract

Human milk provides essential substrates for the optimal growth and development of a breastfed infant. Besides providing nutrients to the infant, human milk also contains metabolites which form an intricate system between maternal lifestyle, such as the mother's diet and the gut microbiome, and infant outcomes. This study investigates the variation of these human milk metabolites from five different countries. Human milk samples (n = 109) were collected one month postpartum from Australia, Japan, the USA, Norway, and South Africa and were analyzed by nuclear magnetic resonance. The partial least squares discriminant analysis (PLS-DA) showed separation between either maternal countries of origin or ethnicities. Variation between countries in concentration of metabolites, such as 2-oxoglutarate, creatine, and glutamine, in human milk, between countries, could provide insights into problems, such as mastitis and/or impaired functions of the mammary glands. Several important markers of milk production, such as lactose, betaine, creatine, glutamate, and glutamine, showed good correlation between each metabolite. This work highlights the importance of milk metabolites with respect to maternal lifestyle and the environment, and also provides the framework for future breastfeeding and microbiome studies in a global context.

Published
2018

16. Maternal smoking during pregnancy increases the risk of gut microbiome-associated childhood overweight and obesity

Author

Peng, Ye, primary, Tun, Hein M, additional, Ng, Siew C, additional, Wai, Hogan Kok-Fung, additional, Zhang, Xi, additional, Parks, Jaclyn, additional, Field, Catherine J, additional, Mandhane, Piush, additional, Moraes, Theo J, additional, Simons, Elinor, additional, Turvey, Stuart E, additional, Subbarao, Padmaja, additional, Brook, Jeffrey R, additional, Takaro, Tim K, additional, Scott, James A, additional, Chan, Francis KL, additional, and Kozyrskyj, Anita L, additional

Published
2024
Full Text
View/download PDF

17. From Birth to Overweight and Atopic Disease: Multiple and Common Pathways of the Infant Gut Microbiome

Author

Vu, Khanh, Lou, Wendy, Tun, Hein M., Konya, Theodore B., Morales-Lizcano, Nadia, Chari, Radha S., Field, Catherine J., Guttman, David S., Mandal, Rupasri, Wishart, David S., Azad, Meghan B., Becker, Allan B., Mandhane, Piush J., Moraes, Theo J., Lefebvre, Diana L., Sears, Malcolm R., Turvey, Stuart E., Subbarao, Padmaja, Scott, James A., and Kozyrskyj, Anita L.

Published
2021
Full Text
View/download PDF

18. Human Milk and Allergic Diseases: An Unsolved Puzzle.

Author

Munblit, Daniel, Peroni, Diego G, Boix-Amorós, Alba, Hsu, Peter S, Van't Land, Belinda, Gay, Melvin CL, Kolotilina, Anastasia, Skevaki, Chrysanthi, Boyle, Robert J, Collado, Maria Carmen, Garssen, Johan, Geddes, Donna T, Nanan, Ralph, Slupsky, Carolyn, Wegienka, Ganesa, Kozyrskyj, Anita L, and Warner, John O

Subjects
Milk, Human, Humans, Hypersensitivity, Oligosaccharides, Micronutrients, Breast Feeding, Meta-Analysis as Topic, Randomized Controlled Trials as Topic, Microbiota, Observational Studies as Topic, allergic diseases, allergy, breastfeeding, cytokines, human milk, microbiome, oligosaccharides, thymus, Milk, Human, Food Sciences, Nutrition and Dietetics
Abstract

There is conflicting evidence on the protective role of breastfeeding in relation to the development of allergic sensitisation and allergic disease. Studies vary in methodology and definition of outcomes, which lead to considerable heterogeneity. Human milk composition varies both within and between individuals, which may partially explain conflicting data. It is known that human milk composition is very complex and contains variable levels of immune active molecules, oligosaccharides, metabolites, vitamins and other nutrients and microbial content. Existing evidence suggests that modulation of human breast milk composition has potential for preventing allergic diseases in early life. In this review, we discuss associations between breastfeeding/human milk composition and allergy development.

Published
2017

19. Decreasing antibiotic use, the gut microbiota, and asthma incidence in children: evidence from population-based and prospective cohort studies

Author

Patrick, David M, Sbihi, Hind, Dai, Darlene L Y, Al Mamun, Abdullah, Rasali, Drona, Rose, Caren, Marra, Fawziah, Boutin, Rozlyn C T, Petersen, Charisse, Stiemsma, Leah T, Winsor, Geoffrey L, Brinkman, Fiona S L, Kozyrskyj, Anita L, Azad, Meghan B, Becker, Allan B, Mandhane, Piush J, Moraes, Theo J, Sears, Malcolm R, Subbarao, Padmaja, Finlay, B Brett, and Turvey, Stuart E

Published
2020
Full Text
View/download PDF

25. Association of use of cleaning products with respiratory health in a Canadian birth cohort

Author

Parks, Jaclyn, McCandless, Lawrence, Dharma, Christoffer, Brook, Jeffrey, Turvey, Stuart E., Mandhane, Piush, Becker, Allan B., Kozyrskyj, Anita L., Azad, Meghan B., Moraes, Theo J., Lefebvre, Diana L., Sears, Malcolm R., Subbarao, Padmaja, Scott, James, and Takaro, Tim K.

Subjects
Parenting, Child development, Childhood asthma -- Risk factors, Medical research, Cleaning agents -- Usage, Allergy -- Risk factors, Wheezing, Childhood, Asthma, Diseases, Children, Health
Abstract

BACKGROUND: Comprehensive longitudinal studies are important for understanding the complex risk factors, pathways, exposures and interactions that lead to the development and persistence of asthma. We aimed to examine associations between use of household cleaning products in early life and childhood respiratory and allergic disease using data from the Canadian Healthy Infant Longitudinal Development (CHILD) Cohort Study. METHODS: We summed responses from parental questionnaires that indicated the frequency of use of 26 household cleaning products in the homes of 2022 children from this birth cohort when they were 3-4 months of age to create a cumulative Frequency of Use Score (FUS). We used multivariable logistic regression models to assess whether frequent compared with less frequent use was associated with recurrent wheeze, atopy or asthma diagnosis, as defined by the questionnaire and clinical assessments at age 3 years. Data were collected between 2008 and 2015. RESULTS: Children in homes with a higher frequency of use of cleaning products in infancy, as determined by an interquartile range increase, had higher odds of recurrent wheeze (adjusted odds ratio [OR] 1.35, 95% confidence interval [CI] 1.11-1.64), recurrent wheeze with atopy (adjusted OR 1.49, 95% CI 1.02-2.16) and asthma diagnosis (adjusted OR 1.37, 95% CI 1.09-1.70), but no increase in the odds of atopy at age 3 years (adjusted OR 1.14, 95% CI 0.96-1.35). Compared with the lowest tertile of FUS exposure, infants in the highest tertile had higher odds of acquiring asthma. Stratification of the results showed that females had higher ORs than males for all outcomes, although the p values for this sex difference did not reach statistical significance. INTERPRETATION: Frequent use of household cleaning products in early life was associated with an increased risk for childhood wheeze and asthma but not atopy at age 3 years. Our findings add to the understanding of how early life exposures to cleaning products may be associated with the development of allergic airway disease and help to identify household behaviours as a potential area for intervention., The prevalence of childhood asthma has steadily increased over the past several decades and is now a leading cause of childhood chronic disease and admissions to hospital in developed countries, [...]

Published
2020
Full Text
View/download PDF

27. Maternal Metabolic Complications in Pregnancy and Offspring Behavior Problems at 2 Years of Age

Author

Krzeczkowski, John E., Lau, Amanda, Fitzpatrick, Jennifer, Tamana, Sukhpreet, Smithson, Lisa, de Souza, Russell, and Kozyrskyj, Anita L.

Subjects
Children -- Behavior, Pregnancy, Complications of -- Risk factors, Pediatric research, Health care industry
Abstract

Objectives Prenatal maternal metabolic problems such as pre-pregnancy adiposity, excess gestational weight gain, and gestational diabetes mellitus (GDM) are associated with an increased risk of psychopathology in offspring. We examined whether these exposures were linked to symptoms of emotional and behavioral problems in offspring at 2 years of age, or if associations were due to confounding variables. Methods Data from 815 mother-child pairs enrolled at the Edmonton site of the Canadian Healthy Infant Longitudinal Development cohort were used to examine associations between gestational metabolic complications and scores on the externalizing and internalizing scales of the Child Behavior Checklist (CBCL-1½ to 5) at age two. Associations between maternal metabolic complications and offspring psychopathology were assessed before and after adjustment for gestational diet, socioeconomic status (SES), postpartum depression (PPD), prenatal smoking and breastfeeding. Results Pre-pregnancy body mass index and GDM, but not gestational weight gain, predicted more offspring externalizing and internalizing problems. However, after adjustment for confounding variables, these associations were no longer statistically significant. Post-hoc analyses revealed that gestational diet accounted for unique variance in both externalizing (semi-partial r.sub.diet = - 0.20, p < 0.001) and internalizing (semi-partial r.sub.diet = - 0.16, p = 0.01) problems. PPD and SES also accounted for a similar amount of variance for both externalizing (semi-partial r.sub.PPD = 0.17, p < 0.001; r.sub.ses = - 0.11, p = 0.03) and internalizing problems (semi-partial r.sub.PPD = 0.21, p < 0.001; r.sub.ses = - 0.14, p = 0.004). Conclusions for Practice Since the confounding effect of gestational diet persisted after adjustment for, and was similar in magnitude to, SES and PPD, future research should consider the impact of unhealthy prenatal diets on offspring neurodevelopment., Author(s): John E. Krzeczkowski [sup.1] , Amanda Lau [sup.2] , Jennifer Fitzpatrick [sup.2] , Sukhpreet Tamana [sup.2] , Lisa Smithson [sup.2] , Russell de Souza [sup.3] , Anita L. Kozyrskyj [...]

Published
2019
Full Text
View/download PDF

28. A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations

Author

Levin, Albert M, Mathias, Rasika A, Huang, Lili, Roth, Lindsey A, Daley, Denise, Myers, Rachel A, Himes, Blanca E, Romieu, Isabelle, Yang, Mao, Eng, Celeste, Park, Julie E, Zoratti, Karla, Gignoux, Christopher R, Torgerson, Dara G, Galanter, Joshua M, Huntsman, Scott, Nguyen, Elizabeth A, Becker, Allan B, Chan-Yeung, Moira, Kozyrskyj, Anita L, Kwok, Pui-Yan, Gilliland, Frank D, Gauderman, W James, Bleecker, Eugene R, Raby, Benjamin A, Meyers, Deborah A, London, Stephanie J, Martinez, Fernando D, Weiss, Scott T, Burchard, Esteban G, Nicolae, Dan L, Ober, Carole, Barnes, Kathleen C, and Williams, L Keoki

Subjects
Biomedical and Clinical Sciences, Immunology, Lung, Human Genome, Clinical Research, Genetics, Asthma, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Adolescent, Adult, Black or African American, Aged, Aged, 80 and over, Canada, Case-Control Studies, Child, Child, Preschool, Female, Genome-Wide Association Study, HLA-DQ beta-Chains, Hispanic or Latino, Humans, Immunoglobulin E, Male, Middle Aged, Polymorphism, Single Nucleotide, United States, White People, Meta-analysis, genome-wide association study, total IgE, race-ethnicity, continental population groups, Allergy
Abstract

BackgroundIgE is both a marker and mediator of allergic inflammation. Despite reported differences in serum total IgE levels by race-ethnicity, African American and Latino subjects have not been well represented in genetic studies of total IgE.ObjectiveWe sought to identify the genetic predictors of serum total IgE levels.MethodsWe used genome-wide association data from 4292 subjects (2469 African Americans, 1564 European Americans, and 259 Latinos) in the EVE Asthma Genetics Consortium. Tests for association were performed within each cohort by race-ethnic group (ie, African American, Latino, and European American) and asthma status. The resulting P values were meta-analyzed, accounting for sample size and direction of effect. Top single nucleotide polymorphism associations from the meta-analysis were reassessed in 6 additional cohorts comprising 5767 subjects.ResultsWe identified 10 unique regions in which the combined association statistic was associated with total serum IgE levels (P

Published
2013

29. Natural Green Spaces, Sensitization to Allergens, and the Role of Gut Microbiota during Infancy

Author

Buchholz, Vienna, primary, Bridgman, Sarah L., additional, Nielsen, Charlene C., additional, Gascon, Mireia, additional, Tun, Hein M., additional, Simons, Elinor, additional, Turvey, Stuart E., additional, Subbarao, Padmaja, additional, Takaro, Tim K., additional, Brook, Jeffrey R., additional, Scott, James A., additional, Mandhane, Piush J., additional, and Kozyrskyj, Anita L., additional

Published
2023
Full Text
View/download PDF

34. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Author

Demenais, Florence, Margaritte-Jeannin, Patricia, Barnes, Kathleen C., Cookson, William O. C., Altmüller, Janine, Ang, Wei, Barr, R. Graham, Beaty, Terri H., Becker, Allan B., Beilby, John, Bisgaard, Hans, Bjornsdottir, Unnur Steina, Bleecker, Eugene, Bønnelykke, Klaus, Boomsma, Dorret I., Bouzigon, Emmanuelle, Brightling, Christopher E., Brossard, Myriam, Brusselle, Guy G., Burchard, Esteban, Burkart, Kristin M., Bush, Andrew, Chan-Yeung, Moira, Chung, Kian Fan, Couto Alves, Alexessander, Curtin, John A., Custovic, Adnan, Daley, Denise, de Jongste, Johan C., Del-Rio-Navarro, Blanca E., Donohue, Kathleen M., Duijts, Liesbeth, Eng, Celeste, Eriksson, Johan G., Farrall, Martin, Fedorova, Yuliya, Feenstra, Bjarke, Ferreira, Manuel A., Freidin, Maxim B., Gajdos, Zofia, Gauderman, Jim, Gehring, Ulrike, Geller, Frank, Genuneit, Jon, Gharib, Sina A., Gilliland, Frank, Granell, Raquel, Graves, Penelope E., Gudbjartsson, Daniel F., Haahtela, Tari, Heckbert, Susan R., Heederik, Dick, Heinrich, Joachim, Heliövaara, Markku, Henderson, John, Himes, Blanca E., Hirose, Hiroshi, Hirschhorn, Joel N., Hofman, Albert, Holt, Patrick, Hottenga, Jouke, Hudson, Thomas J., Hui, Jennie, Imboden, Medea, Ivanov, Vladimir, Jaddoe, Vincent W. V., James, Alan, Janson, Christer, Jarvelin, Marjo-Riitta, Jarvis, Deborah, Jones, Graham, Jonsdottir, Ingileif, Jousilahti, Pekka, Kabesch, Michael, Kähönen, Mika, Kantor, David B., Karunas, Alexandra S., Khusnutdinova, Elza, Koppelman, Gerard H., Kozyrskyj, Anita L., Kreiner, Eskil, Kubo, Michiaki, Kumar, Rajesh, Kumar, Ashish, Kuokkanen, Mikko, Lahousse, Lies, Laitinen, Tarja, Laprise, Catherine, Lathrop, Mark, Lau, Susanne, Lee, Young-Ae, Lehtimäki, Terho, Letort, Sébastien, Levin, Albert M., Li, Guo, Liang, Liming, Loehr, Laura R., London, Stephanie J., Loth, Daan W., Manichaikul, Ani, Marenholz, Ingo, Martinez, Fernando J., Matheson, Melanie C., Mathias, Rasika A., Matsumoto, Kenji, Mbarek, Hamdi, McArdle, Wendy L., Melbye, Mads, Melén, Erik, Meyers, Deborah, Michel, Sven, Mohamdi, Hamida, Musk, Arthur W., Myers, Rachel A., Nieuwenhuis, Maartje A. E., Noguchi, Emiko, O’Connor, George T., Ogorodova, Ludmila M., Palmer, Cameron D., Palotie, Aarno, Park, Julie E., Pennell, Craig E., Pershagen, Göran, Polonikov, Alexey, Postma, Dirkje S., Probst-Hensch, Nicole, Puzyrev, Valery P., Raby, Benjamin A., Raitakari, Olli T., Ramasamy, Adaikalavan, Rich, Stephen S., Robertson, Colin F., Romieu, Isabelle, Salam, Muhammad T., Salomaa, Veikko, Schlünssen, Vivi, Scott, Robert, Selivanova, Polina A., Sigsgaard, Torben, Simpson, Angela, Siroux, Valérie, Smith, Lewis J., Solodilova, Maria, Standl, Marie, Stefansson, Kari, Strachan, David P., Stricker, Bruno H., Takahashi, Atsushi, Thompson, Philip J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiesler, Carla M. T., Torgerson, Dara G., Tsunoda, Tatsuhiko, Uitterlinden, André G., van der Valk, Ralf J. P., Vaysse, Amaury, Vedantam, Sailaja, von Berg, Andrea, von Mutius, Erika, Vonk, Judith M., Waage, Johannes, Wareham, Nick J., Weiss, Scott T., White, Wendy B., Wickman, Magnus, Widén, Elisabeth, Willemsen, Gonneke, Williams, L. Keoki, Wouters, Inge M., Yang, James J., Zhao, Jing Hua, Moffatt, Miriam F., Ober, Carole, and Nicolae, Dan L.

Published
2018
Full Text
View/download PDF

41. Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children

Author

Tun, Mon H., Tun, Hein M., Mahoney, Justin J., Konya, Theodore B., Guttman, David S., Becker, Allan B., Mandhane, Piush J., Turvey, Stuart E., Subbarao, Padmaja, Sears, Malcolm R., Brook, Jeffrey R., Lou, Wendy, Takarao, Tim K., Scott, James A., and Kozyrskyj, Anita L.

Subjects
Mediation, Childhood obesity -- Risk factors, Green products, Child development, Microbiota (Symbiotic organisms), Cleaning agents -- Evaluation -- Usage, Health, University of Manitoba, University of British Columbia, University of Toronto, McMaster University
Abstract

BACKGROUND: Emerging links between household cleaning products and childhood overweight may involve the gut microbiome. We determined mediating effects of infant gut microbiota on associations between home use of cleaning products and future overweight. METHODS: From the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort, we tested associations between maternal report of cleaning product use and overweight at age 3, and whether associations were mediated by microbial profiles of fecal samples in 3- to 4-month-old infants. RESULTS: Among 757 infants, the abundance of specific gut microbiota was associated with household cleaning with disinfectants and eco-friendly products in a dose-dependent manner. With more frequent use of disinfectants, Lachnospiraceae increasingly became more abundant (highest v. lowest quintile of use: adjusted odds ratio [AOR] 1.93, 95% confidence interval [CI] 1.08 to 3.45) while genus Haemophilus declined in abundance (highest v. lowest quintile of use: AOR 0.36, 95% CI 0.20 to 0.65). Enterobacteriaceae were successively depleted with greater use of eco-friendly products (AOR 0.45, 95% CI 0.27 to 0.74). Lachnospiraceae abundance significantly mediated associations of the top 30th centile of household disinfectant use with higher body mass index (BMI) z score (p = 0.02) and with increased odds of overweight or obesity (p = 0.04) at age 3. Use of eco-friendly products was associated with decreased odds of overweight or obesity independently of Enterobacteriaceae abundance (AOR 0.44, 95% CI 0.22 to 0.86), with no significant mediation (p = 0.2). INTERPRETATION: Exposure to household disinfectants was associated with higher BMI at age 3, mediated by gut microbial composition at age 3-4 months. Although child overweight was less common in households that cleaned with eco-friendly products, the lack of mediation by infant gut microbiota suggests another pathway for this association., Greater emphasis on cleanliness has led to widening use of disinfectants and other cleaning agents in the home. (1) Household cleaning products have been associated with elevated risk of wheeze [...]

Published
2018
Full Text
View/download PDF

42. From Prescription Drugs to Natural Health Products: Medication Use in Canadian Infants

Author

Bedard, Pascal, primary, Winsor, Geoffrey L., additional, Garlock, Emma S., additional, Azad, Meghan B., additional, Becker, Allan B., additional, Mandhane, Piush J., additional, Moraes, Theo J., additional, Sears, Malcolm R., additional, Turvey, Stuart E., additional, Subbarao, Padmaja, additional, Brinkman, Fiona S. L., additional, and Kozyrskyj, Anita L., additional

Published
2022
Full Text
View/download PDF

43. The maternal prenatal and offspring early‐life gut microbiome of childhood asthma phenotypes

Author

Lee‐Sarwar, Kathleen A., primary, Chen, Yih‐Chieh, additional, Chen, Yuan Yao, additional, Kozyrskyj, Anita L., additional, Mandhane, Piush J., additional, Turvey, Stuart E., additional, Subbarao, Padmaja, additional, Bisgaard, Hans, additional, Stokholm, Jakob, additional, Chawes, Bo, additional, Sørensen, Søren J., additional, Kelly, Rachel S., additional, Lasky‐Su, Jessica, additional, Zeiger, Robert S., additional, O'Connor, George T., additional, Sandel, Megan T., additional, Bacharier, Leonard B., additional, Beigelman, Avraham, additional, Carey, Vincent J., additional, Harshfield, Benjamin J., additional, Laranjo, Nancy, additional, Gold, Diane R., additional, Weiss, Scott T., additional, and Litonjua, Augusto A., additional

Published
2022
Full Text
View/download PDF

45. Early Life Antimicrobial Exposure: Impact on Clostridioides difficile Colonization in Infants

Author

Obiakor, Chinwe Vivien, primary, Parks, Jaclyn, additional, Takaro, Tim K., additional, Tun, Hein M., additional, Morales-Lizcano, Nadia, additional, Azad, Meghan B., additional, Mandhane, Piushkumar J., additional, Moraes, Theo J., additional, Simons, Elinor, additional, Turvey, Stuart E., additional, Subbarao, Padmaja, additional, Scott, James A., additional, and Kozyrskyj, Anita L., additional

Published
2022
Full Text
View/download PDF

46. Designing the Microbes and Social Equity Symposium: A Novel Interdisciplinary Virtual Research Conference Based on Achieving Group-Directed Outputs

Author

Ishaq, Suzanne L., primary, Wissel, Emily F., additional, Wolf, Patricia G., additional, Grieneisen, Laura, additional, Eggleston, Erin M., additional, Mhuireach, Gwynne, additional, Friedman, Michael, additional, Lichtenwalner, Anne, additional, Otero Machuca, Jessica, additional, Weatherford Darling, Katherine, additional, Pearson, Amber L., additional, Wertheim, Frank S., additional, Johnson, Abigail J., additional, Hodges, Leslie, additional, Young, Sabrina K., additional, Nielsen, Charlene C., additional, Kozyrskyj, Anita L., additional, MacRae, Jean D., additional, Myers, Elise McKenna, additional, Kozik, Ariangela J., additional, Tussing-Humphreys, Lisa Marie, additional, Trujillo, Monica, additional, Daniel, Gaea A., additional, Kramer, Michael R., additional, Donovan, Sharon M., additional, Arshad, Myra, additional, Balkan, Joe, additional, and Hosler, Sarah, additional

Published
2022
Full Text
View/download PDF

47. Birth cohorts in asthma and allergic diseases: Report of a NIAID/NHLBI/MeDALL joint workshop

Author

Bousquet, Jean, Gern, James E., Martinez, Fernando D., Anto, Josep M., Johnson, Christine C., Holt, Patrick G., Lemanske, Robert F., Jr., Le Souëf, Peter N., Tepper, Robert S., von Mutius, Erika R.M., Arshad, S. Hasan, Bacharier, Leonard B., Becker, Allan, Belanger, Kathleen, Bergström, Anna, Bernstein, David I., Cabana, Michael D., Carroll, Kecia N., Castro, Mario, Cooper, Philip J., Gillman, Matthew W., Gold, Diane R., Henderson, John, Heinrich, Joachim, Hong, Soo-Jong, Jackson, Daniel J., Keil, Thomas, Kozyrskyj, Anita L., Lødrup Carlsen, Karin C., Miller, Rachel L., Momas, Isabelle, Morgan, Wayne J., Noel, Patricia, Ownby, Dennis R., Pinart, Mariona, Ryan, Patrick H., Schwaninger, Julie M., Sears, Malcolm R., Simpson, Angela, Smit, Henriette A., Stern, Debra A., Subbarao, Padmaja, Valenta, Rudolf, Wang, Xiaobin, Weiss, Scott T., Wood, Robert, Wright, Anne L., Wright, Rosalind J., Togias, Alkis, and Gergen, Peter J.

Published
2014
Full Text
View/download PDF

49. Traffic, asthma and genetics: combining international birth cohort data to examine genetics as a mediator of traffic-related air pollution's impact on childhood asthma

Author

MacIntyre, Elaina A., Carlsten, Christopher, MacNutt, Meaghan, Fuertes, Elaine, Melén, Eric, Tiesler, Caria M. T., Gehring, Ulrike, Krämer, Ursula, Klümper, Claudia, Kerkhof, Marjan, Chan-Yeung, Moira, Kozyrskyj, Anita L., Berdel, Dietrich, Bauer, Carl Peter, Herbarth, Olf, Bauer, Mario, Schaaf, Beate, Koletzko, Sibylle, Pershagen, Goran, Brunekreef, Bert, Heinrich, Joachim, and Brauer, Michael

Published
2013

50. The maternal prenatal and offspring early‐life gut microbiome of childhood asthma phenotypes.

Author

Lee‐Sarwar, Kathleen A., Chen, Yih‐Chieh, Chen, Yuan Yao, Kozyrskyj, Anita L., Mandhane, Piush J., Turvey, Stuart E., Subbarao, Padmaja, Bisgaard, Hans, Stokholm, Jakob, Chawes, Bo, Sørensen, Søren J., Kelly, Rachel S., Lasky‐Su, Jessica, Zeiger, Robert S., O'Connor, George T., Sandel, Megan T., Bacharier, Leonard B., Beigelman, Avraham, Carey, Vincent J., and Harshfield, Benjamin J.

Subjects
ASTHMA in children, GUT microbiome, THIRD trimester of pregnancy, CESAREAN section, FISHER exact test
Abstract

Background: The infant fecal microbiome is known to impact subsequent asthma risk, but the environmental exposures impacting this association, the role of the maternal microbiome, and how the microbiome impacts different childhood asthma phenotypes are unknown. Methods: Our objective was to identify associations between features of the prenatal and early‐life fecal microbiomes and child asthma phenotypes. We analyzed fecal 16 s rRNA microbiome profiling and fecal metabolomic profiling from stool samples collected from mothers during the third trimester of pregnancy (n = 120) and offspring at ages 3–6 months (n = 265), 1 (n = 436) and 3 years (n = 506) in a total of 657 mother–child pairs participating in the Vitamin D Antenatal Asthma Reduction Trial. We used clinical data from birth to age 6 years to characterize subjects with asthma as having early, transient or active asthma phenotypes. In addition to identifying specific genera that were robustly associated with asthma phenotypes in multiple covariate‐adjusted models, we clustered subjects by their longitudinal microbiome composition and sought associations between fecal metabolites and relevant microbiome and clinical features. Results: Seven maternal and two infant fecal microbial taxa were robustly associated with at least one asthma phenotype, and a longitudinal gut microenvironment profile was associated with early asthma (Fisher exact test p =.03). Though mode of delivery was not directly associated with asthma, we found substantial evidence for a pathway whereby cesarean section reduces fecal Bacteroides and microbial sphingolipids, increasing susceptibility to early asthma. Conclusion: Overall, our results suggest that the early‐life, including prenatal, fecal microbiome modifies risk of asthma, especially asthma with onset by age 3 years. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results