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1. A roll of the dice? Spontaneous activity in electromyography and myositis antibodies

Author: Kleiser, B., primary, Hoffmann, D., additional, Kowarik, M., additional, Dubois, E., additional, Armbruster, M., additional, Grimm, A., additional, and Marquetand, J., additional
Published: 2024
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2. Peripheral memory B cells in multiple sclerosis vs. double negative B cells in neuromyelitis optica spectrum disorder: disease driving B cell subsets during CNS inflammation

Author: Tieck, M. P., primary, Vasilenko, N., additional, Ruschil, C., additional, and Kowarik, M. C., additional
Published: 2024
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3. Differential Effects of Fingolimod and Natalizumab on B Cell Repertoires in Multiple Sclerosis Patients

Author: Kowarik, M. C., Astling, D., Lepennetier, G., Ritchie, A., Hemmer, B., Owens, G. P., and Bennett, Jeffrey L.
Published: 2021
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4. Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data

Author: Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, Wright, MR, Kamal, NR, Andersen, L, Randhawa, PA, Stewart, T, Patil, S, Minhas, P, Almekhlafi, M, Mishra, S, Clement, F, Sajobi, T, Shuaib, A, Montanera, WJ, Roy, D, Silver, FL, Jovin, TG, Frei, DF, Sapkota, B, Rempel, JL, Thornton, J, Williams, D, Tampieri, D, Poppe, AY, Dowlatshahi, D, Wong, JH, Mitha, AP, Subramaniam, S, Hull, G, Lowerison, MW, Salluzzi, M, Maxwell, M, Lacusta, S, Drupals, E, Armitage, K, Barber, PA, Smith, EE, Morrish, WF, Coutts, SB, Derdeyn, C, Demaerschalk, B, Yavagal, D, Martin, R, Brant, R, Yu, Y, Willinsky, RA, Weill, A, Kenney, C, Aram, H, Stys, PK, Watson, TW, Klein, G, Pearson, D, Couillard, P, Trivedi, A, Singh, D, Klourfeld, E, Imoukhuede, O, Nikneshan, D, Blayney, S, Reddy, R, Choi, P, Horton, M, Musuka, T, Dubuc, V, Field, TS, Desai, J, Adatia, S, Alseraya, A, Nambiar, V, van Dijk, R, Newcommon, NJ, Schwindt, B, Butcher, KS, Jeerakathil, T, Buck, B, Khan, K, Naik, SS, Emery, DJ, Owen, RJ, Kotylak, TB, Ashforth, RA, Yeo, TA, McNally, D, Siddiqui, M, Saqqur, M, Hussain, D, Kalashyan, H, Manosalva, A, Kate, M, Gioia, L, Hasan, S, Mohammad, A, Muratoglu, M, Cullen, A, Brennan, P, O'Hare, A, Looby, S, Hyland, D, Duff, S, McCusker, M, Hallinan, B, Lee, S, McCormack, J, Moore, A, O'Connor, M, Donegan, C, Brewer, L, Martin, A, Murphy, S, O'Rourke, K, Smyth, S, Kelly, P, Lynch, T, Daly, T, O'Brien, P, O'Driscoll, A, Martin, M, Collins, R, Coughlan, T, McCabe, D, O'Neill, D, Mulroy, M, Lynch, O, Walsh, T, O'Donnell, M, Galvin, T, Harbison, J, McElwaine, P, Mulpeter, K, McLoughlin, C, Reardon, M, Harkin, E, Dolan, E, Watts, M, Cunningham, N, Fallon, C, Gallagher, S, Cotter, P, Crowe, M, Doyle, R, Noone, I, Lapierre, M, Coté, VA, Lanthier, S, Odier, C, Durocher, A, Raymond, J, Daneault, N, Deschaintre, Y, Jankowitz, B, Baxendell, L, Massaro, L, Jackson-Graves, C, Decesare, S, Porter, P, Armbruster, K, Adams, A, Billigan, J, Oakley, J, Ducruet, A, Jadhav, A, Giurgiutiu, D-V, Aghaebrahim, A, Reddy, V, Hammer, M, Starr, M, Totoraitis, V, Wechsler, L, Streib, S, Rangaraju, S, Campbell, D, Rocha, M, Gulati, D, Krings, T, Kalman, L, Cayley, A, Williams, J, Wiegner, R, Casaubon, LK, Jaigobin, C, del Campo, JM, Elamin, E, Schaafsma, JD, Agid, R, Farb, R, ter Brugge, K, Sapkoda, BL, Baxter, BW, Barton, K, Knox, A, Porter, A, Sirelkhatim, A, Devlin, T, Dellinger, C, Pitiyanuvath, N, Patterson, J, Nichols, J, Quarfordt, S, Calvert, J, Hawk, H, Fanale, C, Bitner, A, Novak, A, Huddle, D, Bellon, R, Loy, D, Wagner, J, Chang, I, Lampe, E, Spencer, B, Pratt, R, Bartt, R, Shine, S, Dooley, G, Nguyen, T, Whaley, M, McCarthy, K, Teitelbaum, J, Poon, W, Campbell, N, Cortes, M, Lum, C, Shamloul, R, Robert, S, Stotts, G, Shamy, M, Steffenhagen, N, Blacquiere, D, Hogan, M, AlHazzaa, M, Basir, G, Lesiuk, H, Iancu, D, Santos, M, Choe, H, Weisman, DC, Jonczak, K, Blue-Schaller, A, Shah, Q, MacKenzie, L, Klein, B, Kulandaivel, K, Kozak, O, Gzesh, DJ, Harris, LJ, Khoury, JS, Mandzia, J, Pelz, D, Crann, S, Fleming, L, Hesser, K, Beauchamp, B, Amato-Marzialli, B, Boulton, M, Lopez- Ojeda, P, Sharma, M, Lownie, S, Chan, R, Swartz, R, Howard, P, Golob, D, Gladstone, D, Boyle, K, Boulos, M, Hopyan, J, Yang, V, Da Costa, L, Holmstedt, CA, Turk, AS, Navarro, R, Jauch, E, Ozark, S, Turner, R, Phillips, S, Shankar, J, Jarrett, J, Gubitz, G, Maloney, W, Vandorpe, R, Schmidt, M, Heidenreich, J, Hunter, G, Kelly, M, Whelan, R, Peeling, L, Burns, PA, Hunter, A, Wiggam, I, Kerr, E, Watt, M, Fulton, A, Gordon, P, Rennie, I, Flynn, P, Smyth, G, O'Leary, S, Gentile, N, Linares, G, McNelis, P, Erkmen, K, Katz, P, Azizi, A, Weaver, M, Jungreis, C, Faro, S, Shah, P, Reimer, H, Kalugdan, V, Saposnik, G, Bharatha, A, Li, Y, Kostyrko, P, Marotta, T, Montanera, W, Sarma, D, Selchen, D, Spears, J, Heo, JH, Jeong, K, Kim, DJ, Kim, BM, Kim, YD, Song, D, Lee, K-J, Yoo, J, Bang, OY, Rho, S, Lee, J, Jeon, P, Kim, KH, Cha, J, Kim, SJ, Ryoo, S, Lee, MJ, Sohn, S-I, Kim, C-H, Ryu, H-G, Hong, J-H, Chang, H-W, Lee, C-Y, Rha, J, Davis, Stephen M, Donnan, Geoffrey A, Campbell, Bruce CV, Mitchell, Peter J, Churilov, Leonid, Yan, Bernard, Dowling, Richard, Yassi, Nawaf, Oxley, Thomas J, Wu, Teddy Y, Silver, Gabriel, McDonald, Amy, McCoy, Rachael, Kleinig, Timothy J, Scroop, Rebecca, Dewey, Helen M, Simpson, Marion, Brooks, Mark, Coulton, Bronwyn, Krause, Martin, Harrington, Timothy J, Steinfort, Brendan, Faulder, Kenneth, Priglinger, Miriam, Day, Susan, Phan, Thanh, Chong, Winston, Holt, Michael, Chandra, Ronil V, Ma, Henry, Young, Dennis, Wong, Kitty, Wijeratne, Tissa, Tu, Hans, Mackay, Elizabeth, Celestino, Sherisse, Bladin, Christopher F, Loh, Poh Sien, Gilligan, Amanda, Ross, Zofia, Coote, Skye, Frost, Tanya, Parsons, Mark W, Miteff, Ferdinand, Levi, Christopher R, Ang, Timothy, Spratt, Neil, Kaauwai, Lara, Badve, Monica, Rice, Henry, de Villiers, Laetitia, Barber, P. Alan, McGuinness, Ben, Hope, Ayton, Moriarty, Maurice, Bennett, Patricia, Wong, Andrew, Coulthard, Alan, Lee, Andrew, Jannes, Jim, Field, Deborah, Sharma, Gagan, Salinas, Simon, Cowley, Elise, Snow, Barry, Kolbe, John, Stark, Richard, King, John, Macdonnell, Richard, Attia, John, D'Este, Cate, Saver, Jeffrey L, Goyal, Mayank, Diener, Hans-Christoph, Levy, Elad I., Bonafé, Alain, Mendes Pereira, Vitor, Jahan, Reza, Albers, Gregory W., Cognard, Christophe, Cohen, David J., Hacke, Werner, Jansen, Olav, Jovin, Tudor G., Mattle, Heinrich P., Nogueira, Raul G., Siddiqui, Adnan H., Yavagal, Dileep R., von Kummer, Rüdiger, Smith, Wade, Turjman, Francis, Hamilton, Scott, Chiacchierini, Richard, Amar, Arun, Sanossian, Nerses, Loh, Yince, Baxter, B, Reddy, VK, Horev, A, Star, M, Siddiqui, A, Hopkins, LN, Snyder, K, Sawyer, R, Hall, S, Costalat, V, Riquelme, C, Machi, P, Omer, E, Arquizan, C, Mourand, I, Charif, M, Ayrignac, X, Menjot de Champfleur, N, Leboucq, N, Gascou, G, Moynier, M, du Mesnil de Rochemont, R, Singer, O, Berkefeld, J, Foerch, C, Lorenz, M, Pfeilschifer, W, Hattingen, E, Wagner, M, You, SJ, Lescher, S, Braun, H, Dehkharghani, S, Belagaje, SR, Anderson, A, Lima, A, Obideen, M, Haussen, D, Dharia, R, Frankel, M, Patel, V, Owada, K, Saad, A, Amerson, L, Horn, C, Doppelheuer, S, Schindler, K, Lopes, DK, Chen, M, Moftakhar, R, Anton, C, Smreczak, M, Carpenter, JS, Boo, S, Rai, A, Roberts, T, Tarabishy, A, Gutmann, L, Brooks, C, Brick, J, Domico, J, Reimann, G, Hinrichs, K, Becker, M, Heiss, E, Selle, C, Witteler, A, Al-Boutros, S, Danch, M-J, Ranft, A, Rohde, S, Burg, K, Weimar, C, Zegarac, V, Hartmann, C, Schlamann, M, Göricke, S, Ringlestein, A, Wanke, I, Mönninghoff, C, Dietzold, M, Budzik, R, Davis, T, Eubank, G, Hicks, WJ, Pema, P, Vora, N, Mejilla, J, Taylor, M, Clark, W, Rontal, A, Fields, J, Peterson, B, Nesbit, G, Lutsep, H, Bozorgchami, H, Priest, R, Ologuntoye, O, Barnwell, S, Dogan, A, Herrick, K, Takahasi, C, Beadell, N, Brown, B, Jamieson, S, Hussain, MS, Russman, A, Hui, F, Wisco, D, Uchino, K, Khawaja, Z, Katzan, I, Toth, G, Cheng-Ching, E, Bain, M, Man, S, Farrag, A, George, P, John, S, Shankar, L, Drofa, A, Dahlgren, R, Bauer, A, Itreat, A, Taqui, A, Cerejo, R, Richmond, A, Ringleb, P, Bendszus, M, Möhlenbruch, M, Reiff, T, Amiri, H, Purrucker, J, Herweh, C, Pham, M, Menn, O, Ludwig, I, Acosta, I, Villar, C, Morgan, W, Sombutmai, C, Hellinger, F, Allen, E, Bellew, M, Gandhi, R, Bonwit, E, Aly, J, Ecker, RD, Seder, D, Morris, J, Skaletsky, M, Belden, J, Baker, C, Connolly, LS, Papanagiotou, P, Roth, C, Kastrup, A, Politi, M, Brunner, F, Alexandrou, M, Merdivan, H, Ramsey, C, Given II, C, Renfrow, S, Deshmukh, V, Sasadeusz, K, Vincent, F, Thiesing, JT, Putnam, J, Bhatt, A, Kansara, A, Caceves, D, Lowenkopf, T, Yanase, L, Zurasky, J, Dancer, S, Freeman, B, Scheibe-Mirek, T, Robison, J, Roll, J, Clark, D, Rodriguez, M, Fitzsimmons, B-FM, Zaidat, O, Lynch, JR, Lazzaro, M, Larson, T, Padmore, L, Das, E, Farrow-Schmidt, A, Hassan, A, Tekle, W, Cate, C, Jansen, O, Cnyrim, C, Wodarg, F, Wiese, C, Binder, A, Riedel, C, Rohr, A, Lang, N, Laufs, H, Krieter, S, Remonda, L, Diepers, M, Añon, J, Nedeltchev, K, Kahles, T, Biethahn, S, Lindner, M, Chang, V, Gächter, C, Esperon, C, Guglielmetti, M, Arenillas Lara, JF, Martínez Galdámez, M, Calleja Sanz, AI, Cortijo Garcia, E, Garcia Bermejo, P, Perez, S, Mulero Carrillo, P, Crespo Vallejo, E, Ruiz Piñero, M, Lopez Mesonero, L, Reyes Muñoz, FJ, Brekenfeld, C, Buhk, J-H, Krützelmann, A, Thomalla, G, Cheng, B, Beck, C, Hoppe, J, Goebell, E, Holst, B, Grzyska, U, Wortmann, G, Starkman, S, Duckwiler, G, Jahan, R, Rao, N, Sheth, S, Ng, K, Noorian, A, Szeder, V, Nour, M, McManus, M, Huang, J, Tarpley, J, Tateshima, S, Gonzalez, N, Ali, L, Liebeskind, D, Hinman, J, Calderon-Arnulphi, M, Liang, C, Guzy, J, Koch, S, DeSousa, K, Gordon-Perue, G, Elhammady, M, Peterson, E, Pandey, V, Dharmadhikari, S, Khandelwal, P, Malik, A, Pafford, R, Gonzalez, P, Ramdas, K, Andersen, G, Damgaard, D, Von Weitzel-Mudersbach, P, Simonsen, C, Ruiz de Morales Ayudarte, N, Poulsen, M, Sørensen, L, Karabegovich, S, Hjørringgaard, M, Hjort, N, Harbo, T, Sørensen, K, Deshaies, E, Padalino, D, Swarnkar, A, Latorre, JG, Elnour, E, El-Zammar, Z, Villwock, M, Farid, H, Balgude, A, Cross, L, Hansen, K, Holtmannspötter, M, Kondziella, D, Hoejgaard, J, Taudorf, S, Soendergaard, H, Wagner, A, Cronquist, M, Stavngaard, T, Cortsen, M, Krarup, LH, Hyldal, T, Haring, H-P, Guggenberger, S, Hamberger, M, Trenkler, J, Sonnberger, M, Nussbaumer, K, Dominger, C, Bach, E, Jagadeesan, BD, Taylor, R, Kim, J, Shea, K, Tummala, R, Zacharatos, H, Sandhu, D, Ezzeddine, M, Grande, A, Hildebrandt, D, Miller, K, Scherber, J, Hendrickson, A, Jumaa, M, Zaidi, S, Hendrickson, T, Snyder, V, Killer-Oberpfalzer, M, Mutzenbach, J, Weymayr, F, Broussalis, E, Stadler, K, Jedlitschka, A, Malek, A, Mueller-Kronast, N, Beck, P, Martin, C, Summers, D, Day, J, Bettinger, I, Holloway, W, Olds, K, Arkin, S, Akhtar, N, Boutwell, C, Crandall, S, Schwartzman, M, Weinstein, C, Brion, B, Prothmann, S, Kleine, J, Kreiser, K, Boeckh-Behrens, T, Poppert, H, Wunderlich, S, Koch, ML, Biberacher, V, Huberle, A, Gora-Stahlberg, G, Knier, B, Meindl, T, Utpadel-Fischler, D, Zech, M, Kowarik, M, Seifert, C, Schwaiger, B, Puri, A, Hou, S, Wakhloo, A, Moonis, M, Henninger, N, Goddeau, R, Massari, F, Minaeian, A, Lozano, JD, Ramzan, M, Stout, C, Patel, A, Tunguturi, A, Onteddu, S, Carandang, R, Howk, M, Ribó, M, Sanjuan, E, Rubiera, M, Pagola, J, Flores, A, Muchada, M, Meler, P, Huerga, E, Gelabert, S, Coscojuela, P, Tomasello, A, Rodriguez, D, Santamarina, E, Maisterra, O, Boned, S, Seró, L, Rovira, A, Molina, CA, Millán, M, Muñoz, L, Pérez de la Ossa, N, Gomis, M, Dorado, L, López-Cancio, E, Palomeras, E, Munuera, J, García Bermejo, P, Remollo, S, Castaño, C, García-Sort, R, Cuadras, P, Puyalto, P, Hernández-Pérez, M, Jiménez, M, Martínez-Piñeiro, A, Lucente, G, Dávalos, A, Chamorro, A, Urra, X, Obach, V, Cervera, A, Amaro, S, Llull, L, Codas, J, Balasa, M, Navarro, J, Ariño, H, Aceituno, A, Rudilosso, S, Renu, A, Macho, JM, San Roman, L, Blasco, J, López, A, Macías, N, Cardona, P, Quesada, H, Rubio, F, Cano, L, Lara, B, de Miquel, MA, Aja, L, Serena, J, Cobo, E, Albers, Gregory W, Lees, Kennedy R, Arenillas, J, Roberts, R, Al-Ajlan, F, Zimmel, L, Patel, S, Martí-Fàbregas, J, Salvat-Plana, M, Bracard, S, Ducrocq, Xavier, Anxionnat, René, Baillot, Pierre-Alexandre, Barbier, Charlotte, Derelle, Anne-Laure, Lacour, Jean-Christophe, Richard, Sébastien, Samson, Yves, Sourour, Nader, Baronnet-Chauvet, Flore, Clarencon, Frédéric, Crozier, Sophie, Deltour, Sandrine, Di Maria, Federico, Le Bouc, Raphael, Leger, Anne, Mutlu, Gurkan, Rosso, Charlotte, Szatmary, Zoltan, Yger, Marion, Zavanone, Chiara, Bakchine, Serge, Pierot, Laurent, Caucheteux, Nathalie, Estrade, Laurent, Kadziolka, Krzysztof, Leautaud, Alexandre, Renkes, Céline, Serre, Isabelle, Desal, Hubert, Guillon, Benoît, Boutoleau-Bretonniere, Claire, Daumas-Duport, Benjamin, De Gaalon, Solène, Derkinderen, Pascal, Evain, Sarah, Herisson, Fanny, Laplaud, David-Axel, Lebouvier, Thibaud, Lintia-Gaultier, Alina, Pouclet-Courtemanche, Hélène, Rouaud, Tiphaine, Rouaud Jaffrenou, Violaine, Schunck, Aurélia, Sevin-Allouet, Mathieu, Toulgoat, Frederique, Wiertlewski, Sandrine, Gauvrit, Jean-Yves, Ronziere, Thomas, Cahagne, Vincent, Ferre, Jean-Christophe, Pinel, Jean-François, Raoult, Hélène, Mas, Jean-Louis, Meder, Jean-François, Al Najjar-Carpentier, Amen-Adam, Birchenall, Julia, Bodiguel, Eric, Calvet, David, Domigo, Valérie, Godon-Hardy, Sylvie, Guiraud, Vincent, Lamy, Catherine, Majhadi, Loubna, Morin, Ludovic, Naggara, Olivier, Trystram, Denis, Turc, Guillaume, Berge, Jérôme, Sibon, Igor, Menegon, Patrice, Barreau, Xavier, Rouanet, François, Debruxelles, Sabrina, Kazadi, Annabelle, Renou, Pauline, Fleury, Olivier, Pasco-Papon, Anne, Dubas, Frédéric, Caroff, Jildaz, Godard Ducceschi, Sophie, Hamon, Marie-Aurélie, Lecluse, Alderic, Marc, Guillaume, Giroud, Maurice, Ricolfi, Frédéric, Bejot, Yannick, Chavent, Adrien, Gentil, Arnaud, Kazemi, Apolline, Osseby, Guy-Victor, Voguet, Charlotte, Mahagne, Marie-Hélène, Sedat, Jacques, Chau, Yves, Suissa, Laurent, Lachaud, Sylvain, Houdart, Emmanuel, Stapf, Christian, Buffon Porcher, Frédérique, Chabriat, Hugues, Guedin, Pierre, Herve, Dominique, Jouvent, Eric, Mawet, Jérôme, Saint-Maurice, Jean-Pierre, Schneble, Hans-Martin, Nighoghossian, Norbert, Berhoune, Nadia-Nawel, Bouhour, Françoise, Cho, Tae-Hee, Derex, Laurent, Felix, Sandra, Gervais-Bernard, Hélène, Gory, Benjamin, Manera, Luis, Mechtouff, Laura, Ritzenthaler, Thomas, Riva, Roberto, Salaris Silvio, Fabrizio, Tilikete, Caroline, Blanc, Raphael, Obadia, Michaël, Bartolini, Mario Bruno, Gueguen, Antoine, Piotin, Michel, Pistocchi, Silvia, Redjem, Hocine, Drouineau, Jacques, Neau, Jean-Philippe, Godeneche, Gaelle, Lamy, Matthias, Marsac, Emilia, Velasco, Stephane, Clavelou, Pierre, Chabert, Emmanuel, Bourgois, Nathalie, Cornut-Chauvinc, Catherine, Ferrier, Anna, Gabrillargues, Jean, Jean, Betty, Marques, Anna-Raquel, Vitello, Nicolas, Detante, Olivier, Barbieux, Marianne, Boubagra, Kamel, Favre Wiki, Isabelle, Garambois, Katia, Tahon, Florence, Ashok, Vasdev, Coskun, Oguzhan, Rodesch, Georges, Lapergue, Bertrand, Bourdain, Frédéric, Evrard, Serge, Graveleau, Philippe, Decroix, Jean Pierre, Wang, Adrien, Sellal, François, Ahle, Guido, Carelli, Gabriela, Dugay, Marie-Hélène, Gaultier, Claude, Lebedinsky, Ariel Pablo, Lita, Lavinia, Musacchio, Raul Mariano, Renglewicz-Destuynder, Catherine, Tournade, Alain, Vuillemet, Françis, Montoro, Francisco Macian, Mounayer, Charbel, Faugeras, Frederic, Gimenez, Laetitia, Labach, Catherine, Lautrette, Géraldine, Denier, Christian, Saliou, Guillaume, Chassin, Olivier, Dussaule, Claire, Melki, Elsa, Ozanne, Augustin, Puccinelli, Francesco, Sachet, Marina, Sarov, Mariana, Bonneville, Jean-François, Moulin, Thierry, Biondi, Alessandra, De Bustos Medeiros, Elisabeth, Vuillier, Fabrice, Courtheoux, Patrick, Viader, Fausto, Apoil-Brissard, Marion, Bataille, Mathieu, Bonnet, Anne-Laure, Cogez, Julien, Touze, Emmanuel, Leclerc, Xavier, Leys, Didier, Aggour, Mohamed, Aguettaz, Pierre, Bodenant, Marie, Cordonnier, Charlotte, Deplanque, Dominique, Girot, Marie, Henon, Hilde, Kalsoum, Erwah, Lucas, Christian, Pruvo, Jean-Pierre, Zuniga, Paolo, Arquizan, Caroline, Costalat, Vincent, Machi, Paolo, Mourand, Isabelle, Riquelme, Carlos, Bounolleau, Pierre, Arteaga, Charles, Faivre, Anthony, Bintner, Marc, Tournebize, Patrice, Charlin, Cyril, Darcel, Françoise, Gauthier-Lasalarie, Pascale, Jeremenko, Marcia, Mouton, Servane, Zerlauth, Jean-Baptiste, Lamy, Chantal, Hervé, Deramond, Hassan, Hosseini, Gaston, André, Barral, Francis-Guy, Garnier, Pierre, Beaujeux, Rémy, Wolff, Valérie, Herbreteau, Denis, Debiais, Séverine, Murray, Alicia, Ford, Gary, Muir, Keith W, White, Philip, Clifton, Andy, Freeman, Janet, Ford, Ian, Markus, Hugh, Wardlaw, 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Alejandro, Brown, Scott, Liebeskind, David S, Bracard, Serge, Dippel, Diederik W J, Jovin, Tudor G, and Hill, Michael D
Published: 2019
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5. Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data

Author: Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, Wright, MR, Kamal, NR, Andersen, L, Randhawa, PA, Stewart, T, Patil, S, Minhas, P, Almekhlafi, M, Mishra, S, Clement, F, Sajobi, T, Shuaib, A, Montanera, WJ, Roy, D, Silver, FL, Jovin, TG, Frei, DF, Sapkota, B, Rempel, JL, Thornton, J, Williams, D, Tampieri, D, Poppe, AY, Dowlatshahi, D, Wong, JH, Mitha, AP, Subramaniam, S, Hull, G, Lowerison, MW, Salluzzi, M, Maxwell, M, Lacusta, S, Drupals, E, Armitage, K, Barber, PA, Smith, EE, Morrish, WF, Coutts, SB, Derdeyn, C, Demaerschalk, B, Yavagal, D, Martin, R, Brant, R, Yu, Y, Willinsky, RA, Weill, A, Kenney, C, Aram, H, Stys, PK, Watson, TW, Klein, G, Pearson, D, Couillard, P, Trivedi, A, Singh, D, Klourfeld, E, Imoukhuede, O, Nikneshan, D, Blayney, S, Reddy, R, Choi, P, Horton, M, Musuka, T, Dubuc, V, Field, TS, Desai, J, Adatia, S, Alseraya, A, Nambiar, V, van Dijk, R, Newcommon, NJ, Schwindt, B, Butcher, KS, Jeerakathil, T, Buck, B, Khan, K, Naik, SS, Emery, DJ, Owen, RJ, Kotylak, TB, Ashforth, RA, Yeo, TA, McNally, D, 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Alan, McGuinness, Ben, Hope, Ayton, Moriarty, Maurice, Bennett, Patricia, Wong, Andrew, Coulthard, Alan, Lee, Andrew, Jannes, Jim, Field, Deborah, Sharma, Gagan, Salinas, Simon, Cowley, Elise, Snow, Barry, Kolbe, John, Stark, Richard, King, John, Macdonnell, Richard, Attia, John, D'Este, Cate, Saver, Jeffrey L, Goyal, Mayank, Diener, Hans-Christoph, Levy, Elad I., Bonafé, Alain, Mendes Pereira, Vitor, Jahan, Reza, Albers, Gregory W., Cognard, Christophe, Cohen, David J., Hacke, Werner, Jansen, Olav, Jovin, Tudor G., Mattle, Heinrich P., Nogueira, Raul G., Siddiqui, Adnan H., Yavagal, Dileep R., von Kummer, Rüdiger, Smith, Wade, Turjman, Francis, Hamilton, Scott, Chiacchierini, Richard, Amar, Arun, Sanossian, Nerses, Loh, Yince, Baxter, B, Reddy, VK, Horev, A, Star, M, Siddiqui, A, Hopkins, LN, Snyder, K, Sawyer, R, Hall, S, Costalat, V, Riquelme, C, Machi, P, Omer, E, Arquizan, C, Mourand, I, Charif, M, Ayrignac, X, Menjot de Champfleur, N, Leboucq, N, Gascou, G, Moynier, M, du Mesnil de Rochemont, R, Singer, O, Berkefeld, J, Foerch, C, Lorenz, M, Pfeilschifer, W, Hattingen, E, Wagner, M, You, SJ, Lescher, S, Braun, H, Dehkharghani, S, Belagaje, SR, Anderson, A, Lima, A, Obideen, M, Haussen, D, Dharia, R, Frankel, M, Patel, V, Owada, K, Saad, A, Amerson, L, Horn, C, Doppelheuer, S, Schindler, K, Lopes, DK, Chen, M, Moftakhar, R, Anton, C, Smreczak, M, Carpenter, JS, Boo, S, Rai, A, Roberts, T, Tarabishy, A, Gutmann, L, Brooks, C, Brick, J, Domico, J, Reimann, G, Hinrichs, K, Becker, M, Heiss, E, Selle, C, Witteler, A, Al-Boutros, S, Danch, M-J, Ranft, A, Rohde, S, Burg, K, Weimar, C, Zegarac, V, Hartmann, C, Schlamann, M, Göricke, S, Ringlestein, A, Wanke, I, Mönninghoff, C, Dietzold, M, Budzik, R, Davis, T, Eubank, G, Hicks, WJ, Pema, P, Vora, N, Mejilla, J, Taylor, M, Clark, W, Rontal, A, Fields, J, Peterson, B, Nesbit, G, Lutsep, H, Bozorgchami, H, Priest, R, Ologuntoye, O, Barnwell, S, Dogan, A, Herrick, K, Takahasi, C, Beadell, N, Brown, B, Jamieson, S, Hussain, MS, Russman, A, Hui, F, Wisco, D, Uchino, K, Khawaja, Z, Katzan, I, Toth, G, Cheng-Ching, E, Bain, M, Man, S, Farrag, A, George, P, John, S, Shankar, L, Drofa, A, Dahlgren, R, Bauer, A, Itreat, A, Taqui, A, Cerejo, R, Richmond, A, Ringleb, P, Bendszus, M, Möhlenbruch, M, Reiff, T, Amiri, H, Purrucker, J, Herweh, C, Pham, M, Menn, O, Ludwig, I, Acosta, I, Villar, C, Morgan, W, Sombutmai, C, Hellinger, F, Allen, E, Bellew, M, Gandhi, R, Bonwit, E, Aly, J, Ecker, RD, Seder, D, Morris, J, Skaletsky, M, Belden, J, Baker, C, Connolly, LS, Papanagiotou, P, Roth, C, Kastrup, A, Politi, M, Brunner, F, Alexandrou, M, Merdivan, H, Ramsey, C, Given II, C, Renfrow, S, Deshmukh, V, Sasadeusz, K, Vincent, F, Thiesing, JT, Putnam, J, Bhatt, A, Kansara, A, Caceves, D, Lowenkopf, T, Yanase, L, Zurasky, J, Dancer, S, Freeman, B, Scheibe-Mirek, T, Robison, J, Roll, J, Clark, D, Rodriguez, M, Fitzsimmons, B-FM, Zaidat, O, Lynch, JR, Lazzaro, M, Larson, T, Padmore, L, Das, E, Farrow-Schmidt, A, 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Ajlan, Fahad S, Reddy, Vivek, Dowlatshahi, Dar, Sourour, Nader-Antoine, Oppenheim, Catherine, Mitha, Alim P, Weimar, Christian, van Oostenbrugge, Robert J, Cobo, Erik, Demchuk, Andrew M, Boers, Anna M M, Ford, Gary A, Brown, B Scott, Jovin, Tudor, van Zwam, Wim H, Hill, Michael D, White, Phil, and Bracard, Serge
Published: 2018
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6. Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

Author: Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, Wright, MR, Kamal, NR, Andersen, L, Randhawa, PA, Stewart, T, Patil, S, Minhas, P, Almekhlafi, M, Mishra, S, Clement, F, Sajobi, T, Shuaib, A, Montanera, WJ, Roy, D, Silver, FL, Jovin, TG, Frei, DF, Sapkota, B, Rempel, JL, Thornton, J, Williams, D, Tampieri, D, Poppe, AY, Dowlatshahi, D, Wong, JH, Mitha, AP, Subramaniam, S, Hull, G, Lowerison, MW, Salluzzi, M, Maxwell, M, Lacusta, S, Drupals, E, Armitage, K, Barber, PA, Smith, EE, Morrish, WF, Coutts, SB, Derdeyn, C, Demaerschalk, B, Yavagal, D, Martin, R, Brant, R, Yu, Y, Willinsky, RA, Weill, A, Kenney, C, Aram, H, Stys, PK, Watson, TW, Klein, G, Pearson, D, Couillard, P, Trivedi, A, Singh, D, Klourfeld, E, Imoukhuede, O, Nikneshan, D, Blayney, S, Reddy, R, Choi, P, Horton, M, Musuka, T, Dubuc, V, Field, TS, Desai, J, Adatia, S, Alseraya, A, Nambiar, V, van Dijk, R, Newcommon, NJ, Schwindt, B, Butcher, KS, Jeerakathil, T, Buck, B, Khan, K, Naik, SS, Emery, DJ, Owen, RJ, Kotylak, TB, Ashforth, RA, Yeo, TA, McNally, D, 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Boutwell, C, Crandall, S, Schwartzman, M, Weinstein, C, Brion, B, Prothmann, S, Kleine, J, Kreiser, K, Boeckh-Behrens, T, Poppert, H, Wunderlich, S, Koch, ML, Biberacher, V, Huberle, A, Gora-Stahlberg, G, Knier, B, Meindl, T, Utpadel-Fischler, D, Zech, M, Kowarik, M, Seifert, C, Schwaiger, B, Puri, A, Hou, S, Wakhloo, A, Moonis, M, Henninger, N, Goddeau, R, Massari, F, Minaeian, A, Lozano, JD, Ramzan, M, Stout, C, Patel, A, Tunguturi, A, Onteddu, S, Carandang, R, Howk, M, Ribó, M, Sanjuan, E, Rubiera, M, Pagola, J, Flores, A, Muchada, M, Meler, P, Huerga, E, Gelabert, S, Coscojuela, P, Tomasello, A, Rodriguez, D, Santamarina, E, Maisterra, O, Boned, S, Seró, L, Rovira, A, Molina, CA, Millán, M, Muñoz, L, Pérez de la Ossa, N, Gomis, M, Dorado, L, López-Cancio, E, Palomeras, E, Munuera, J, García Bermejo, P, Remollo, S, Castaño, C, García-Sort, R, Cuadras, P, Puyalto, P, Hernández-Pérez, M, Jiménez, M, Martínez-Piñeiro, A, Lucente, G, Dávalos, A, Chamorro, A, Urra, X, Obach, V, Cervera, A, Amaro, S, Llull, L, Codas, J, Balasa, M, Navarro, J, Ariño, H, Aceituno, A, Rudilosso, S, Renu, A, Macho, JM, San Roman, L, Blasco, J, López, A, Macías, N, Cardona, P, Quesada, H, Rubio, F, Cano, L, Lara, B, de Miquel, MA, Aja, L, Serena, J, Cobo, E, Albers, Gregory W, Lees, Kennedy R, Arenillas, J, Roberts, R, Al-Ajlan, F, Zimmel, L, Patel, S, Martí-Fàbregas, J, Salvat-Plana, M, Bracard, S, Ducrocq, Xavier, Anxionnat, René, Baillot, Pierre-Alexandre, Barbier, Charlotte, Derelle, Anne-Laure, Lacour, Jean-Christophe, Richard, Sébastien, Samson, Yves, Sourour, Nader, Baronnet-Chauvet, Flore, Clarencon, Frédéric, Crozier, Sophie, Deltour, Sandrine, Di Maria, Federico, Le Bouc, Raphael, Leger, Anne, Mutlu, Gurkan, Rosso, Charlotte, Szatmary, Zoltan, Yger, Marion, Zavanone, Chiara, Bakchine, Serge, Pierot, Laurent, Caucheteux, Nathalie, Estrade, Laurent, Kadziolka, Krzysztof, Leautaud, Alexandre, Renkes, Céline, Serre, Isabelle, Desal, Hubert, Guillon, Benoît, Boutoleau-Bretonniere, Claire, Daumas-Duport, Benjamin, De Gaalon, Solène, Derkinderen, Pascal, Evain, Sarah, Herisson, Fanny, Laplaud, David-Axel, Lebouvier, Thibaud, Lintia-Gaultier, Alina, Pouclet-Courtemanche, Hélène, Rouaud, Tiphaine, Rouaud Jaffrenou, Violaine, Schunck, Aurélia, Sevin-Allouet, Mathieu, Toulgoat, Frederique, Wiertlewski, Sandrine, Gauvrit, Jean-Yves, Ronziere, Thomas, Cahagne, Vincent, Ferre, Jean-Christophe, Pinel, Jean-François, Raoult, Hélène, Mas, Jean-Louis, Meder, Jean-François, Al Najjar-Carpentier, Amen-Adam, Birchenall, Julia, Bodiguel, Eric, Calvet, David, Domigo, Valérie, Godon-Hardy, Sylvie, Guiraud, Vincent, Lamy, Catherine, Majhadi, Loubna, Morin, Ludovic, Naggara, Olivier, Trystram, Denis, Turc, Guillaume, Berge, Jérôme, Sibon, Igor, Menegon, Patrice, Barreau, Xavier, Rouanet, François, Debruxelles, Sabrina, Kazadi, Annabelle, Renou, Pauline, Fleury, Olivier, Pasco-Papon, Anne, Dubas, Frédéric, Caroff, Jildaz, Godard Ducceschi, Sophie, Hamon, Marie-Aurélie, Lecluse, Alderic, Marc, Guillaume, Giroud, Maurice, Ricolfi, Frédéric, Bejot, Yannick, Chavent, Adrien, Gentil, Arnaud, Kazemi, Apolline, Osseby, Guy-Victor, Voguet, Charlotte, Mahagne, Marie-Hélène, Sedat, Jacques, Chau, Yves, Suissa, Laurent, Lachaud, Sylvain, Houdart, Emmanuel, Stapf, Christian, Buffon Porcher, Frédérique, Chabriat, Hugues, Guedin, Pierre, Herve, Dominique, Jouvent, Eric, Mawet, Jérôme, Saint-Maurice, Jean-Pierre, Schneble, Hans-Martin, Nighoghossian, Norbert, Berhoune, Nadia-Nawel, Bouhour, Françoise, Cho, Tae-Hee, Derex, Laurent, Felix, Sandra, Gervais-Bernard, Hélène, Gory, Benjamin, Manera, Luis, Mechtouff, Laura, Ritzenthaler, Thomas, Riva, Roberto, Salaris Silvio, Fabrizio, Tilikete, Caroline, Blanc, Raphael, Obadia, Michaël, Bartolini, Mario Bruno, Gueguen, Antoine, Piotin, Michel, Pistocchi, Silvia, Redjem, Hocine, Drouineau, Jacques, Neau, Jean-Philippe, Godeneche, Gaelle, Lamy, Matthias, Marsac, Emilia, Velasco, Stephane, Clavelou, Pierre, Chabert, Emmanuel, Bourgois, Nathalie, Cornut-Chauvinc, Catherine, Ferrier, Anna, Gabrillargues, Jean, Jean, Betty, Marques, Anna-Raquel, Vitello, Nicolas, Detante, Olivier, Barbieux, Marianne, Boubagra, Kamel, Favre Wiki, Isabelle, Garambois, Katia, Tahon, Florence, Ashok, Vasdev, Coskun, Oguzhan, Rodesch, Georges, Lapergue, Bertrand, Bourdain, Frédéric, Evrard, Serge, Graveleau, Philippe, Decroix, Jean Pierre, Wang, Adrien, Sellal, François, Ahle, Guido, Carelli, Gabriela, Dugay, Marie-Hélène, Gaultier, Claude, Lebedinsky, Ariel Pablo, Lita, Lavinia, Musacchio, Raul Mariano, Renglewicz-Destuynder, Catherine, Tournade, Alain, Vuillemet, Françis, Montoro, Francisco Macian, Mounayer, Charbel, Faugeras, Frederic, Gimenez, Laetitia, Labach, Catherine, Lautrette, Géraldine, Denier, Christian, Saliou, Guillaume, Chassin, Olivier, Dussaule, Claire, Melki, Elsa, Ozanne, Augustin, Puccinelli, Francesco, Sachet, Marina, Sarov, Mariana, Bonneville, Jean-François, Moulin, Thierry, Biondi, Alessandra, De Bustos Medeiros, Elisabeth, Vuillier, Fabrice, Courtheoux, Patrick, Viader, Fausto, Apoil-Brissard, Marion, Bataille, Mathieu, Bonnet, Anne-Laure, Cogez, Julien, Touze, Emmanuel, Leclerc, Xavier, Leys, Didier, Aggour, Mohamed, Aguettaz, Pierre, Bodenant, Marie, Cordonnier, Charlotte, Deplanque, Dominique, Girot, Marie, Henon, Hilde, Kalsoum, Erwah, Lucas, Christian, Pruvo, Jean-Pierre, Zuniga, Paolo, Arquizan, Caroline, Costalat, Vincent, Machi, Paolo, Mourand, Isabelle, Riquelme, Carlos, Bounolleau, Pierre, Arteaga, Charles, Faivre, Anthony, Bintner, Marc, Tournebize, Patrice, Charlin, Cyril, Darcel, Françoise, Gauthier-Lasalarie, Pascale, Jeremenko, Marcia, Mouton, Servane, Zerlauth, Jean-Baptiste, Lamy, Chantal, Hervé, Deramond, Hassan, Hosseini, Gaston, André, Barral, Francis-Guy, Garnier, Pierre, Beaujeux, Rémy, Wolff, Valérie, Herbreteau, Denis, Debiais, Séverine, Murray, Alicia, Ford, Gary, Muir, Keith W, White, Philip, Brown, Martin M, Clifton, Andy, Freeman, Janet, Ford, Ian, Markus, Hugh, Wardlaw, Joanna, Molyneux, Andy, Robinson, Thompson, Lewis, Steff, Norrie, John, Robertson, Fergus, Perry, Richard, Dixit, Anand, Cloud, Geoffrey, Clifton, Andrew, Madigan, Jeremy, Roffe, Christine, Nayak, Sanjeev, Lobotesis, Kyriakos, Smith, Craig, Herwadkar, Amit, Kandasamy, Naga, Goddard, Tony, Bamford, John, Subramanian, Ganesh, Lenthall, Rob, Littleton, Edward, Lamin, Sal, Storey, Kelley, Ghatala, Rita, Banaras, Azra, Aeron-Thomas, John, Hazel, Bath, Maguire, Holly, Veraque, Emelda, Harrison, Louise, Keshvara, Rekha, Cunningham, James, Campbell, Bruce C V, van Zwam, Wim H, Menon, Bijoy K, Dippel, Diederik W J, Demchuk, Andrew M, Bracard, Serge, Dávalos, Antoni, Majoie, Charles B L M, Ford, Gary A, de la Ossa, Natalia Pérez, Kelly, Michael, Bourcier, Romain, Roos, Yvo B W E M, Bang, Oh Young, Nogueira, Raul G, Devlin, Thomas G, Clarençon, Frédéric, Burns, Paul, Carpenter, Jeffrey, Yavagal, Dileep R, Pereira, Vitor Mendes, Quesada, Helena, Epstein, Jonathan, Rubiera, Marta, Urra, Xabier, Micard, Emilien, Brown, Scott, Guillemin, Francis, van Oostenbrugge, Robert J, Jovin, Tudor G, and Hill, Michael D
Published: 2018
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7. Apheresis therapies for NMOSD attacks: A retrospective study of 207 therapeutic interventions

Author: Kleiter, Ingo, Gahlen, Anna, Borisow, Nadja, Fischer, Katrin, Wernecke, Klaus-Dieter, Hellwig, Kerstin, Pache, Florence, Ruprecht, Klemens, Havla, Joachim, Kümpfel, Tania, Aktas, Orhan, Hartung, Hans-Peter, Ringelstein, Marius, Geis, Christian, Kleinschnitz, Christoph, Berthele, Achim, Hemmer, Bernhard, Angstwurm, Klemens, Stellmann, Jan-Patrick, Schuster, Simon, Stangel, Martin, Lauda, Florian, Tumani, Hayrettin, Mayer, Christoph, Krumbholz, Markus, Zeltner, Lena, Ziemann, Ulf, Linker, Ralf, Schwab, Matthias, Marziniak, Martin, Then Bergh, Florian, Hofstadt-van Oy, Ulrich, Neuhaus, Oliver, Zettl, Uwe K., Faiss, Jürgen, Wildemann, Brigitte, Paul, Friedemann, Jarius, Sven, Trebst, Corinna, Albrecht, P., Ayzenberg, I., Bayas, A., Bellmann-Strobl, J., Bischof, F., Bittner, S., Böttcher, T., Brettschneider, J., Buttmann, M., DSouza, M., Ettrich, B., Frank, B., Gass, A., Grothe, M., Guthke, K., Haarmann, A., Habedank, E., Hoffmann, F., Hoffmann, O., Hümmert, M.W., Junghans, J., Kaste, M., Kaulen, B., Kermer, P., Kern, P., Klotz, L., Köhler, W., Kolesilova, E., Korsen, M., Kowarik, M., Langel, S., Lee, D.H., Liebetrau, M., Luessi, F., Marouf, W., Meister, S., Melms, A., Metz, I., Münch, C., Niehaus, S., Pawlitzki, M., Pellkofer, H., Puhlmann, H.U., Pul, R., Retzlaf, N., Riedlinger, A., Rommer, P., Röpke, L., Rostásy, K., Rückriem, L., Ruschil, C., Schippling, S., Senel, M., Sieb, J.P., Sommer, C., Spreer, A., Steinbrecher, A., Stephanik, H., Stoppe, M., Süße, M., Tackenberg, B., Tünnerhoff, J., Veauthier, C., Walter, A., Wandinger, K.P., Warnke, C., Weber, M.S., Weissert, R., Wiendl, H., Wilke, C., Winkelmann, A., Yalachkov, Y., Young, K., Zentner, C., and Zipp, F.
Published: 2018
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8. Immune cell subtyping in the cerebrospinal fluid of patients with neurological diseases

Author: Kowarik, M. C., Grummel, V., Wemlinger, S., Buck, D., Weber, M. S., Berthele, A., and Hemmer, B.
Published: 2014
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9. Long-term safety and efficacy of Eculizumab in Aquaporin-4 IgG-positive NMOSD

Author: Wingerchuk, D.M., Fujihara, K., Palace, J., Berthele, A., Levy, M., Kim, H.J., Nakashima, I., Oreja-Guevara, C., Wang, K.-C., Miller, L., Shang, S., Sabatella, G., Yountz, M., Pittock, S.J., Villa, A., Garcea, O., Manin, A., Melamud, L., Aguirre, F., Fernandez, V., Munoz, D.J., Amor, J., Bocchiardo, C., Obregon, C.D.D., Laffue, A., Paez, M.F., Perez, R.M., Rocchi, V., Teijeiro, L., De Virgiliis, M., Cordoba, M., Ingolotti, M., Lupinacci, A., Ballario, C., Chiesa, A., Gomez, H., Mainella, C., Lattini, H., Barnett, M., Barton, J., Beadnall, H., Garber, J., Hardy, T., Pollard, J., Trewin, B., Shuey, N., Bryson, A., French, A., Laing, J., Law, L.Y., Plummer, C., Sanders, L., Sedal, L., Winkel, A., Neal, A., Habek, M., Adamec, I., Barun, B., Crnosija, L., Gabelic, T., Pitha, J., Nytrova, P., Novakova, I., Tyblova, M., Krasulova, E., Pavlickova, J., Petersen, T., Rasmussen, P., Stilund, M., Svendsen, K., Diem, R., Platten, M., Berberich, A., Jaschonek, H., Wildemann, B., Biberacher, V.M., Brinkhoff, K., Golkowski, D., Kowarik, M., Lehmann-Horn, K., Pongratz, V., Zettl, U., Klinke, J., Loebermann, M., Meister, S., Rimmele, F., Winkelmann, A., Lau, A.Y.L., Au, L.W.C., Fan, S.Y.F., Ip, V.H.L., Ma, S.H., Ma, K.Y.K., Mok, C.T.V., Patti, F., Messina, S., Proietto, M., Filla, A., Morra, V.B., Costabile, T., Nozzolillo, A., Sacc, Sacca, Tackley, George, and MATUR, ZELİHA
Subjects: 0301 basic medicine, medicine.medical_specialty, Neuromyelitis optica, business.industry, Maintenance dose, Eculizumab, Placebo, Interim analysis, medicine.disease, Confidence interval, ddc, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Aquaporin 4, Neurology, Internal medicine, Medicine, Neurology (clinical), Adverse effect, business, Research Articles, 030217 neurology & neurosurgery, Research Article, medicine.drug
Abstract: Objective\udDuring PREVENT (NCT01892345), eculizumab significantly reduced relapse risk versus placebo in patients with aquaporin-4 immunoglobulin G-positive neuromyelitis optica spectrum disorder (AQP4-IgG+ NMOSD). We report an interim analysis of PREVENT's ongoing open-label extension (OLE; NCT02003144) evaluating eculizumab's long-term safety and efficacy.\ud\udMethods\udPatients who completed PREVENT could enroll in the OLE to receive eculizumab (maintenance dose = 1,200 mg/2 weeks, after a blinded induction phase). Safety and efficacy data from PREVENT and its OLE (interim data cut, July 31, 2019) were combined for this analysis.\ud\udResults\udAcross PREVENT and the OLE, 137 patients received eculizumab and were monitored for a median (range) of 133.3 weeks (5.1–276.9 weeks), for a combined total of 362.3 patient-years (PY). Treatment-related adverse event (AE) and serious adverse event (SAE) rates were 183.5 in 100 PY and 8.6 in 100 PY, respectively. Serious infection rates were 10.2 in 100 PY in eculizumab-treated patients versus 15.1 in 100 PY in the PREVENT placebo group. No patient developed a meningococcal infection. At 192 weeks (3.7 years), 94.4% (95% confidence interval [CI], 88.6–97.3) of patients remained adjudicated relapse-free. The adjudicated annualized relapse rate was 0.025 (95% CI = 0.013–0.048) in all eculizumab-treated patients versus 0.350 (95% CI = 0.199–0.616) in the PREVENT placebo group. During the OLE, 37% of patients (44 of 119 patients) stopped or decreased background immunosuppressive therapy use.\ud\udInterpretation\udThis analysis demonstrates that eculizumab's long-term safety profile in NMOSD is consistent with its established profile across other indications. This analysis also demonstrated the sustained ability of long-term eculizumab treatment to reduce relapse risk in patients with AQP4-IgG+ NMOSD. ANN NEUROL 2021;89:1088–1098
Published: 2021

10. Differential Effects of Fingolimod and Natalizumab on B Cell Repertoires in Multiple Sclerosis Patients

Author: Kowarik, M. C., primary, Astling, D., additional, Lepennetier, G., additional, Ritchie, A., additional, Hemmer, B., additional, Owens, G. P., additional, and Bennett, Jeffrey L., additional
Published: 2020
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11. Differential effects of disease modifying drugs on peripheral blood B cell subsets: A cross sectional study in multiple sclerosis patients treated with interferon-β, glatiramer acetate, dimethyl fumarate, fingolimod or natalizumab

Author: Kemmerer, C. L., primary, Pernpeintner, V., additional, Ruschil, C., additional, Abdelhak, A., additional, Scholl, M., additional, Ziemann, U., additional, Krumbholz, M., additional, Hemmer, B., additional, and Kowarik, M. C., additional
Published: 2020
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12. Differential effects of disease modifying drugs on peripheral blood B cell subsets: A cross sectional study in multiple sclerosis patients treated with interferon-β, glatiramer acetate, dimethyl fumarate, fingolimod or natalizumab

Author: Kemmerer, C. L., Pernpeintner, V., Ruschil, C., Abdelhak, A., Scholl, M., Ziemann, U., Krumbholz, M., Hemmer, B., and Kowarik, M. C.
Subjects: ddc
Published: 2019

13. Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data

Author: Campbell, Bruce C V, primary, Majoie, Charles B L M, additional, Albers, Gregory W, additional, Menon, Bijoy K, additional, Yassi, Nawaf, additional, Sharma, Gagan, additional, van Zwam, Wim H, additional, van Oostenbrugge, Robert J, additional, Demchuk, Andrew M, additional, Guillemin, Francis, additional, White, Philip, additional, Dávalos, Antoni, additional, van der Lugt, Aad, additional, Butcher, Kenneth S, additional, Cherifi, Aboubaker, additional, Marquering, Henk A, additional, Cloud, Geoffrey, additional, Macho Fernández, Juan M, additional, Madigan, Jeremy, additional, Oppenheim, Catherine, additional, Donnan, Geoffrey A, additional, Roos, Yvo B W E M, additional, Shankar, Jai, additional, Lingsma, Hester, additional, Bonafé, Alain, additional, Raoult, Hélène, additional, Hernández-Pérez, María, additional, Bharatha, Aditya, additional, Jahan, Reza, additional, Jansen, Olav, additional, Richard, Sébastien, additional, Levy, Elad I, additional, Berkhemer, Olvert A, additional, Soudant, Marc, additional, Aja, Lucia, additional, Davis, Stephen M, additional, Krings, Timo, additional, Tisserand, Marie, additional, San Román, Luis, additional, Tomasello, Alejandro, additional, Beumer, Debbie, additional, Brown, Scott, additional, Liebeskind, David S, additional, Bracard, Serge, additional, Muir, Keith W, additional, Dippel, Diederik W J, additional, Goyal, Mayank, additional, Saver, Jeffrey L, additional, Jovin, Tudor G, additional, Hill, Michael D, additional, Mitchell, Peter J, additional, Fransen, Puck SS, additional, van den Berg, Lucie A, additional, Lingsma, Hester F, additional, Yoo, Albert J, additional, Schonewille, Wouter J, additional, Vos, Jan Albert, additional, Nederkoorn, Paul J, additional, Wermer, Marieke JH, additional, van Walderveen, Marianne AA, additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, van Oostayen, Jacques A., additional, Lycklama à Nijeholt, Geert J., additional, Boiten, Jelis, additional, Brouwer, Patrick A., additional, Emmer, Bart J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Kappelle, Jaap, additional, Lo, Rob H, additional, van Dijk, Ewoud J., additional, de Vries, Joost, additional, de Kort, Paul L.M., additional, van Rooij, Willem Jan J., additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Visser, Marieke C., additional, Bot, Joseph C.J., additional, Vroomen, Patrick C., additional, Eshghi, Omid, additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Tielbeek, Alexander V., additional, den Hertog, Heleen M., additional, Gerrits, Dick G., additional, van den Berg-Vos, Renske M., additional, Karas, Giorgos B., additional, Steyerberg, Ewout W., additional, Flach, Zwenneke, additional, Marquering, Henk A., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, Beenen, Ludo F.M., additional, van den Berg, René, additional, Koudstaal, Peter J., additional, van Zwam, Wim H., additional, Roos, Yvo B.W.E.M., additional, van Oostenbrugge, Robert J., additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, Brown, Martin M., additional, Liebig, Thomas, additional, Stijnen, Theo, additional, Andersson, Tommy, additional, Mattle, Heinrich, additional, Wahlgren, Nils, additional, van der Heijden, Esther, additional, Ghannouti, Naziha, additional, Fleitour, Nadine, additional, Hooijenga, Imke, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Geerling, Annet, additional, Lindl-Velema, Annemieke, additional, van Vemde, Gina, additional, de Ridder, Ans, additional, Greebe, Paut, additional, de Bont-Stikkelbroeck, José, additional, de Meris, Joke, additional, Janssen, Kirsten, additional, Struijk, Willy, additional, Licher, Silvan, additional, Boodt, Nikki, additional, Ros, Adriaan, additional, Venema, Esmee, additional, Slokkers, Ilse, additional, Ganpat, Raymie-Jayce, additional, Mulder, Maxim, additional, Saiedie, Nawid, additional, Heshmatollah, Alis, additional, Schipperen, Stefanie, additional, Vinken, Stefan, additional, van Boxtel, Tiemen, additional, Koets, Jeroen, additional, Boers, Merel, additional, Santos, Emilie, additional, Borst, Jordi, additional, Jansen, Ivo, additional, Kappelhof, Manon, additional, Lucas, Marit, additional, Geuskens, Ralph, additional, Barros, Renan Sales, additional, Dobbe, Roeland, additional, Csizmadia, Marloes, additional, Hill, MD, additional, Goyal, M, additional, Demchuk, AM, additional, Menon, BK, additional, Eesa, M, additional, Ryckborst, KJ, additional, Wright, MR, additional, Kamal, NR, additional, Andersen, L, additional, Randhawa, PA, additional, Stewart, T, additional, Patil, S, additional, Minhas, P, additional, Almekhlafi, M, additional, Mishra, S, additional, Clement, F, additional, Sajobi, T, additional, Shuaib, A, additional, Montanera, WJ, additional, Roy, D, additional, Silver, FL, additional, Jovin, TG, additional, Frei, DF, additional, Sapkota, B, additional, Rempel, JL, additional, Thornton, J, additional, Williams, D, additional, Tampieri, D, additional, Poppe, AY, additional, Dowlatshahi, D, additional, Wong, JH, additional, Mitha, AP, additional, Subramaniam, S, additional, Hull, G, additional, Lowerison, MW, additional, Salluzzi, M, additional, Maxwell, M, additional, Lacusta, S, additional, Drupals, E, additional, Armitage, K, additional, Barber, PA, additional, Smith, EE, additional, Morrish, WF, additional, Coutts, SB, additional, Derdeyn, C, additional, Demaerschalk, B, additional, Yavagal, D, additional, Martin, R, additional, Brant, R, additional, Yu, Y, additional, Willinsky, RA, additional, Weill, A, additional, Kenney, C, additional, Aram, H, additional, Stys, PK, additional, Watson, TW, additional, Klein, G, additional, Pearson, D, additional, Couillard, P, additional, Trivedi, A, additional, Singh, D, additional, Klourfeld, E, additional, Imoukhuede, O, additional, Nikneshan, D, additional, Blayney, S, additional, Reddy, R, additional, Choi, P, additional, Horton, M, additional, Musuka, T, additional, Dubuc, V, additional, Field, TS, additional, Desai, J, additional, Adatia, S, additional, Alseraya, A, additional, Nambiar, V, additional, van Dijk, R, additional, Newcommon, NJ, additional, Schwindt, B, additional, Butcher, KS, additional, Jeerakathil, T, additional, Buck, B, additional, Khan, K, additional, Naik, SS, additional, Emery, DJ, additional, Owen, RJ, additional, Kotylak, TB, additional, Ashforth, RA, additional, Yeo, TA, additional, McNally, D, additional, Siddiqui, M, additional, Saqqur, M, additional, Hussain, D, additional, Kalashyan, H, additional, Manosalva, A, additional, Kate, M, additional, Gioia, L, additional, Hasan, S, additional, Mohammad, A, additional, Muratoglu, M, additional, Cullen, A, additional, Brennan, P, additional, O'Hare, A, additional, Looby, S, additional, Hyland, D, additional, Duff, S, additional, McCusker, M, additional, Hallinan, B, additional, Lee, S, additional, McCormack, J, additional, Moore, A, additional, O'Connor, M, additional, Donegan, C, additional, Brewer, L, additional, Martin, A, additional, Murphy, S, additional, O'Rourke, K, additional, Smyth, S, additional, Kelly, P, additional, Lynch, T, additional, Daly, T, additional, O'Brien, P, additional, O'Driscoll, A, additional, Martin, M, additional, Collins, R, additional, Coughlan, T, additional, McCabe, D, additional, O'Neill, D, additional, Mulroy, M, additional, Lynch, O, additional, Walsh, T, additional, O'Donnell, M, additional, Galvin, T, additional, Harbison, J, additional, McElwaine, P, additional, Mulpeter, K, additional, McLoughlin, C, additional, Reardon, M, additional, Harkin, E, additional, Dolan, E, additional, Watts, M, additional, Cunningham, N, additional, Fallon, C, additional, Gallagher, S, additional, Cotter, P, additional, Crowe, M, additional, Doyle, R, additional, Noone, I, additional, Lapierre, M, additional, Coté, VA, additional, Lanthier, S, additional, Odier, C, additional, Durocher, A, additional, Raymond, J, additional, Daneault, N, additional, Deschaintre, Y, additional, Jankowitz, B, additional, Baxendell, L, additional, Massaro, L, additional, Jackson-Graves, C, additional, Decesare, S, additional, Porter, P, additional, Armbruster, K, additional, Adams, A, additional, Billigan, J, additional, Oakley, J, additional, Ducruet, A, additional, Jadhav, A, additional, Giurgiutiu, D-V, additional, Aghaebrahim, A, additional, Reddy, V, additional, Hammer, M, additional, Starr, M, additional, Totoraitis, V, additional, Wechsler, L, additional, Streib, S, additional, Rangaraju, S, additional, Campbell, D, additional, Rocha, M, additional, Gulati, D, additional, Krings, T, additional, Kalman, L, additional, Cayley, A, additional, Williams, J, additional, Wiegner, R, additional, Casaubon, LK, additional, Jaigobin, C, additional, del Campo, JM, additional, Elamin, E, additional, Schaafsma, JD, additional, Agid, R, additional, Farb, R, additional, ter Brugge, K, additional, Sapkoda, BL, additional, Baxter, BW, additional, Barton, K, additional, Knox, A, additional, Porter, A, additional, Sirelkhatim, A, additional, Devlin, T, additional, Dellinger, C, additional, Pitiyanuvath, N, additional, Patterson, J, additional, Nichols, J, additional, Quarfordt, S, additional, Calvert, J, additional, Hawk, H, additional, Fanale, C, additional, Bitner, A, additional, Novak, A, additional, Huddle, D, additional, Bellon, R, additional, Loy, D, additional, Wagner, J, additional, Chang, I, additional, Lampe, E, additional, Spencer, B, additional, Pratt, R, additional, Bartt, R, additional, Shine, S, additional, Dooley, G, additional, Nguyen, T, additional, Whaley, M, additional, McCarthy, K, additional, Teitelbaum, J, additional, Poon, W, additional, Campbell, N, additional, Cortes, M, additional, Lum, C, additional, Shamloul, R, additional, Robert, S, additional, Stotts, G, additional, Shamy, M, additional, Steffenhagen, N, additional, Blacquiere, D, additional, Hogan, M, additional, AlHazzaa, M, additional, Basir, G, additional, Lesiuk, H, additional, Iancu, D, additional, Santos, M, additional, Choe, H, additional, Weisman, DC, additional, Jonczak, K, additional, Blue-Schaller, A, additional, Shah, Q, additional, MacKenzie, L, additional, Klein, B, additional, Kulandaivel, K, additional, Kozak, O, additional, Gzesh, DJ, additional, Harris, LJ, additional, Khoury, JS, additional, Mandzia, J, additional, Pelz, D, additional, Crann, S, additional, Fleming, L, additional, Hesser, K, additional, Beauchamp, B, additional, Amato-Marzialli, B, additional, Boulton, M, additional, Lopez- Ojeda, P, additional, Sharma, M, additional, Lownie, S, additional, Chan, R, additional, Swartz, R, additional, Howard, P, additional, Golob, D, additional, Gladstone, D, additional, Boyle, K, additional, Boulos, M, additional, Hopyan, J, additional, Yang, V, additional, Da Costa, L, additional, Holmstedt, CA, additional, Turk, AS, additional, Navarro, R, additional, Jauch, E, additional, Ozark, S, additional, Turner, R, additional, Phillips, S, additional, Shankar, J, additional, Jarrett, J, additional, Gubitz, G, additional, Maloney, W, additional, Vandorpe, R, additional, Schmidt, M, additional, Heidenreich, J, additional, Hunter, G, additional, Kelly, M, additional, Whelan, R, additional, Peeling, L, additional, Burns, PA, additional, Hunter, A, additional, Wiggam, I, additional, Kerr, E, additional, Watt, M, additional, Fulton, A, additional, Gordon, P, additional, Rennie, I, additional, Flynn, P, additional, Smyth, G, additional, O'Leary, S, additional, Gentile, N, additional, Linares, G, additional, McNelis, P, additional, Erkmen, K, additional, Katz, P, additional, Azizi, A, additional, Weaver, M, additional, Jungreis, C, additional, Faro, S, additional, Shah, P, additional, Reimer, H, additional, Kalugdan, V, additional, Saposnik, G, additional, Bharatha, A, additional, Li, Y, additional, Kostyrko, P, additional, Marotta, T, additional, Montanera, W, additional, Sarma, D, additional, Selchen, D, additional, Spears, J, additional, Heo, JH, additional, Jeong, K, additional, Kim, DJ, additional, Kim, BM, additional, Kim, YD, additional, Song, D, additional, Lee, K-J, additional, Yoo, J, additional, Bang, OY, additional, Rho, S, additional, Lee, J, additional, Jeon, P, additional, Kim, KH, additional, Cha, J, additional, Kim, SJ, additional, Ryoo, S, additional, Lee, MJ, additional, Sohn, S-I, additional, Kim, C-H, additional, Ryu, H-G, additional, Hong, J-H, additional, Chang, H-W, additional, Lee, C-Y, additional, Rha, J, additional, Campbell, Bruce CV, additional, Churilov, Leonid, additional, Yan, Bernard, additional, Dowling, Richard, additional, Oxley, Thomas J, additional, Wu, Teddy Y, additional, Silver, Gabriel, additional, McDonald, Amy, additional, McCoy, Rachael, additional, Kleinig, Timothy J, additional, Scroop, Rebecca, additional, Dewey, Helen M, additional, Simpson, Marion, additional, Brooks, Mark, additional, Coulton, Bronwyn, additional, Krause, Martin, additional, Harrington, Timothy J, additional, Steinfort, Brendan, additional, Faulder, Kenneth, additional, Priglinger, Miriam, additional, Day, Susan, additional, Phan, Thanh, additional, Chong, Winston, additional, Holt, Michael, additional, Chandra, Ronil V, additional, Ma, Henry, additional, Young, Dennis, additional, Wong, Kitty, additional, Wijeratne, Tissa, additional, Tu, Hans, additional, Mackay, Elizabeth, additional, Celestino, Sherisse, additional, Bladin, Christopher F, additional, Loh, Poh Sien, additional, Gilligan, Amanda, additional, Ross, Zofia, additional, Coote, Skye, additional, Frost, Tanya, additional, Parsons, Mark W, additional, Miteff, Ferdinand, additional, Levi, Christopher R, additional, Ang, Timothy, additional, Spratt, Neil, additional, Kaauwai, Lara, additional, Badve, Monica, additional, Rice, Henry, additional, de Villiers, Laetitia, additional, Barber, P. Alan, additional, McGuinness, Ben, additional, Hope, Ayton, additional, Moriarty, Maurice, additional, Bennett, Patricia, additional, Wong, Andrew, additional, Coulthard, Alan, additional, Lee, Andrew, additional, Jannes, Jim, additional, Field, Deborah, additional, Salinas, Simon, additional, Cowley, Elise, additional, Snow, Barry, additional, Kolbe, John, additional, Stark, Richard, additional, King, John, additional, Macdonnell, Richard, additional, Attia, John, additional, D'Este, Cate, additional, Diener, Hans-Christoph, additional, Levy, Elad I., additional, Mendes Pereira, Vitor, additional, Albers, Gregory W., additional, Cognard, Christophe, additional, Cohen, David J., additional, Hacke, Werner, additional, Jovin, Tudor G., additional, Mattle, Heinrich P., additional, Nogueira, Raul G., additional, Siddiqui, Adnan H., additional, Yavagal, Dileep R., additional, von Kummer, Rüdiger, additional, Smith, Wade, additional, Turjman, Francis, additional, Hamilton, Scott, additional, Chiacchierini, Richard, additional, Amar, Arun, additional, Sanossian, Nerses, additional, Loh, Yince, additional, Baxter, B, additional, Reddy, VK, additional, Horev, A, additional, Star, M, additional, Siddiqui, A, additional, Hopkins, LN, additional, Snyder, K, additional, Sawyer, R, additional, Hall, S, additional, Costalat, V, additional, Riquelme, C, additional, Machi, P, additional, Omer, E, additional, Arquizan, C, additional, Mourand, I, additional, Charif, M, additional, Ayrignac, X, additional, Menjot de Champfleur, N, additional, Leboucq, N, additional, Gascou, G, additional, Moynier, M, additional, du Mesnil de Rochemont, R, additional, Singer, O, additional, Berkefeld, J, additional, Foerch, C, additional, Lorenz, M, additional, Pfeilschifer, W, additional, Hattingen, E, additional, Wagner, M, additional, You, SJ, additional, Lescher, S, additional, Braun, H, additional, Dehkharghani, S, additional, Belagaje, SR, additional, Anderson, A, additional, Lima, A, additional, Obideen, M, additional, Haussen, D, additional, Dharia, R, additional, Frankel, M, additional, Patel, V, additional, Owada, K, additional, Saad, A, additional, Amerson, L, additional, Horn, C, additional, Doppelheuer, S, additional, Schindler, K, additional, Lopes, DK, additional, Chen, M, additional, Moftakhar, R, additional, Anton, C, additional, Smreczak, M, additional, Carpenter, JS, additional, Boo, S, additional, Rai, A, additional, Roberts, T, additional, Tarabishy, A, additional, Gutmann, L, additional, Brooks, C, additional, Brick, J, additional, Domico, J, additional, Reimann, G, additional, Hinrichs, K, additional, Becker, M, additional, Heiss, E, additional, Selle, C, additional, Witteler, A, additional, Al-Boutros, S, additional, Danch, M-J, additional, Ranft, A, additional, Rohde, S, additional, Burg, K, additional, Weimar, C, additional, Zegarac, V, additional, Hartmann, C, additional, Schlamann, M, additional, Göricke, S, additional, Ringlestein, A, additional, Wanke, I, additional, Mönninghoff, C, additional, Dietzold, M, additional, Budzik, R, additional, Davis, T, additional, Eubank, G, additional, Hicks, WJ, additional, Pema, P, additional, Vora, N, additional, Mejilla, J, additional, Taylor, M, additional, Clark, W, additional, Rontal, A, additional, Fields, J, additional, Peterson, B, additional, Nesbit, G, additional, Lutsep, H, additional, Bozorgchami, H, additional, Priest, R, additional, Ologuntoye, O, additional, Barnwell, S, additional, Dogan, A, additional, Herrick, K, additional, Takahasi, C, additional, Beadell, N, additional, Brown, B, additional, Jamieson, S, additional, Hussain, MS, additional, Russman, A, additional, Hui, F, additional, Wisco, D, additional, Uchino, K, additional, Khawaja, Z, additional, Katzan, I, additional, Toth, G, additional, Cheng-Ching, E, additional, Bain, M, additional, Man, S, additional, Farrag, A, additional, George, P, additional, John, S, additional, Shankar, L, additional, Drofa, A, additional, 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M, additional, McManus, M, additional, Huang, J, additional, Tarpley, J, additional, Tateshima, S, additional, Gonzalez, N, additional, Ali, L, additional, Liebeskind, D, additional, Hinman, J, additional, Calderon-Arnulphi, M, additional, Liang, C, additional, Guzy, J, additional, Koch, S, additional, DeSousa, K, additional, Gordon-Perue, G, additional, Elhammady, M, additional, Peterson, E, additional, Pandey, V, additional, Dharmadhikari, S, additional, Khandelwal, P, additional, Malik, A, additional, Pafford, R, additional, Gonzalez, P, additional, Ramdas, K, additional, Andersen, G, additional, Damgaard, D, additional, Von Weitzel-Mudersbach, P, additional, Simonsen, C, additional, Ruiz de Morales Ayudarte, N, additional, Poulsen, M, additional, Sørensen, L, additional, Karabegovich, S, additional, Hjørringgaard, M, additional, Hjort, N, additional, Harbo, T, additional, Sørensen, K, additional, Deshaies, E, additional, Padalino, D, additional, Swarnkar, A, additional, Latorre, JG, additional, Elnour, E, additional, El-Zammar, Z, additional, Villwock, M, additional, Farid, H, additional, Balgude, A, additional, Cross, L, additional, Hansen, K, additional, Holtmannspötter, M, additional, Kondziella, D, additional, Hoejgaard, J, additional, Taudorf, S, additional, Soendergaard, H, additional, Wagner, A, additional, Cronquist, M, additional, Stavngaard, T, additional, Cortsen, M, additional, Krarup, LH, additional, Hyldal, T, additional, Haring, H-P, additional, Guggenberger, S, additional, Hamberger, M, additional, Trenkler, J, additional, Sonnberger, M, additional, Nussbaumer, K, additional, Dominger, C, additional, Bach, E, additional, Jagadeesan, BD, additional, Taylor, R, additional, Kim, J, additional, Shea, K, additional, Tummala, R, additional, Zacharatos, H, additional, Sandhu, D, additional, Ezzeddine, M, additional, Grande, A, additional, Hildebrandt, D, additional, Miller, K, additional, Scherber, J, additional, Hendrickson, A, additional, Jumaa, M, additional, Zaidi, S, additional, Hendrickson, T, additional, Snyder, V, additional, Killer-Oberpfalzer, M, additional, Mutzenbach, J, additional, Weymayr, F, additional, Broussalis, E, additional, Stadler, K, additional, Jedlitschka, A, additional, Malek, A, additional, Mueller-Kronast, N, additional, Beck, P, additional, Martin, C, additional, Summers, D, additional, Day, J, additional, Bettinger, I, additional, Holloway, W, additional, Olds, K, additional, Arkin, S, additional, Akhtar, N, additional, Boutwell, C, additional, Crandall, S, additional, Schwartzman, M, additional, Weinstein, C, additional, Brion, B, additional, Prothmann, S, additional, Kleine, J, additional, Kreiser, K, additional, Boeckh-Behrens, T, additional, Poppert, H, additional, Wunderlich, S, additional, Koch, ML, additional, Biberacher, V, additional, Huberle, A, additional, Gora-Stahlberg, G, additional, Knier, B, additional, Meindl, T, additional, Utpadel-Fischler, D, additional, Zech, M, additional, Kowarik, M, additional, Seifert, C, additional, Schwaiger, B, additional, Puri, A, additional, Hou, S, additional, Wakhloo, A, additional, Moonis, M, additional, Henninger, N, additional, Goddeau, R, additional, Massari, F, additional, Minaeian, A, additional, Lozano, JD, additional, Ramzan, M, additional, Stout, C, additional, Patel, A, additional, Tunguturi, A, additional, Onteddu, S, additional, Carandang, R, additional, Howk, M, additional, Ribó, M, additional, Sanjuan, E, additional, Rubiera, M, additional, Pagola, J, additional, Flores, A, additional, Muchada, M, additional, Meler, P, additional, Huerga, E, additional, Gelabert, S, additional, Coscojuela, P, additional, Tomasello, A, additional, Rodriguez, D, additional, Santamarina, E, additional, Maisterra, O, additional, Boned, S, additional, Seró, L, additional, Rovira, A, additional, Molina, CA, additional, Millán, M, additional, Muñoz, L, additional, Pérez de la Ossa, N, additional, Gomis, M, additional, Dorado, L, additional, López-Cancio, E, additional, Palomeras, E, additional, Munuera, J, additional, García Bermejo, P, additional, Remollo, S, additional, Castaño, C, additional, García-Sort, R, additional, Cuadras, P, additional, Puyalto, P, additional, Hernández-Pérez, M, additional, Jiménez, M, additional, Martínez-Piñeiro, A, additional, Lucente, G, additional, Dávalos, A, additional, Chamorro, A, additional, Urra, X, additional, Obach, V, additional, Cervera, A, additional, Amaro, S, additional, Llull, L, additional, Codas, J, additional, Balasa, M, additional, Navarro, J, additional, Ariño, H, additional, Aceituno, A, additional, Rudilosso, S, additional, Renu, A, additional, Macho, JM, additional, San Roman, L, additional, Blasco, J, additional, López, A, additional, Macías, N, additional, Cardona, P, additional, Quesada, H, additional, Rubio, F, additional, Cano, L, additional, Lara, B, additional, de Miquel, MA, additional, Aja, L, additional, Serena, J, additional, Cobo, E, additional, Lees, Kennedy R, additional, Arenillas, J, additional, Roberts, R, additional, Al-Ajlan, F, additional, Zimmel, L, additional, Patel, S, additional, Martí-Fàbregas, J, additional, Salvat-Plana, M, additional, Bracard, S, additional, Ducrocq, Xavier, additional, Anxionnat, René, additional, Baillot, Pierre-Alexandre, additional, Barbier, Charlotte, additional, Derelle, Anne-Laure, additional, Lacour, Jean-Christophe, additional, Samson, Yves, additional, Sourour, Nader, additional, Baronnet-Chauvet, Flore, additional, Clarencon, Frédéric, additional, Crozier, Sophie, additional, Deltour, Sandrine, additional, Di Maria, Federico, additional, Le Bouc, Raphael, additional, Leger, Anne, additional, Mutlu, Gurkan, additional, Rosso, Charlotte, additional, Szatmary, Zoltan, additional, Yger, Marion, additional, Zavanone, Chiara, additional, Bakchine, Serge, additional, Pierot, Laurent, additional, Caucheteux, Nathalie, additional, Estrade, Laurent, additional, Kadziolka, Krzysztof, additional, Leautaud, Alexandre, additional, Renkes, Céline, additional, Serre, Isabelle, additional, Desal, Hubert, additional, Guillon, Benoît, additional, Boutoleau-Bretonniere, Claire, additional, Daumas-Duport, Benjamin, additional, De Gaalon, Solène, additional, Derkinderen, Pascal, additional, Evain, Sarah, additional, Herisson, Fanny, additional, Laplaud, David-Axel, additional, Lebouvier, Thibaud, additional, Lintia-Gaultier, Alina, additional, Pouclet-Courtemanche, Hélène, additional, Rouaud, Tiphaine, additional, Rouaud Jaffrenou, Violaine, additional, Schunck, Aurélia, additional, Sevin-Allouet, Mathieu, additional, Toulgoat, Frederique, additional, Wiertlewski, Sandrine, additional, Gauvrit, Jean-Yves, additional, Ronziere, Thomas, additional, Cahagne, Vincent, additional, Ferre, Jean-Christophe, additional, Pinel, Jean-François, additional, Mas, Jean-Louis, additional, Meder, Jean-François, additional, Al Najjar-Carpentier, Amen-Adam, additional, Birchenall, Julia, additional, Bodiguel, Eric, additional, Calvet, David, additional, Domigo, Valérie, additional, Godon-Hardy, Sylvie, additional, Guiraud, Vincent, additional, Lamy, Catherine, additional, Majhadi, Loubna, additional, Morin, Ludovic, additional, Naggara, Olivier, additional, Trystram, Denis, additional, Turc, Guillaume, additional, Berge, Jérôme, additional, Sibon, Igor, additional, Menegon, Patrice, additional, Barreau, Xavier, additional, Rouanet, François, additional, Debruxelles, Sabrina, additional, Kazadi, Annabelle, additional, Renou, Pauline, additional, Fleury, Olivier, additional, Pasco-Papon, Anne, additional, Dubas, Frédéric, additional, Caroff, Jildaz, additional, Godard Ducceschi, Sophie, additional, Hamon, Marie-Aurélie, additional, Lecluse, Alderic, additional, Marc, Guillaume, additional, Giroud, Maurice, additional, Ricolfi, Frédéric, additional, Bejot, Yannick, additional, Chavent, Adrien, additional, Gentil, Arnaud, additional, Kazemi, Apolline, additional, Osseby, Guy-Victor, additional, Voguet, Charlotte, additional, Mahagne, Marie-Hélène, additional, Sedat, Jacques, additional, Chau, Yves, additional, Suissa, Laurent, additional, Lachaud, Sylvain, additional, Houdart, Emmanuel, additional, Stapf, Christian, additional, Buffon Porcher, Frédérique, additional, Chabriat, Hugues, additional, Guedin, Pierre, additional, Herve, Dominique, additional, Jouvent, Eric, additional, Mawet, Jérôme, additional, Saint-Maurice, Jean-Pierre, additional, Schneble, Hans-Martin, additional, Nighoghossian, Norbert, additional, Berhoune, Nadia-Nawel, additional, Bouhour, Françoise, additional, Cho, Tae-Hee, additional, Derex, Laurent, additional, Felix, Sandra, additional, Gervais-Bernard, Hélène, additional, Gory, Benjamin, additional, Manera, Luis, additional, Mechtouff, Laura, additional, Ritzenthaler, Thomas, additional, Riva, Roberto, additional, Salaris Silvio, Fabrizio, additional, Tilikete, Caroline, additional, Blanc, Raphael, additional, Obadia, Michaël, additional, Bartolini, Mario Bruno, additional, Gueguen, Antoine, additional, Piotin, Michel, additional, Pistocchi, Silvia, additional, Redjem, Hocine, additional, Drouineau, Jacques, additional, Neau, Jean-Philippe, additional, Godeneche, Gaelle, additional, Lamy, Matthias, additional, Marsac, Emilia, additional, Velasco, Stephane, additional, Clavelou, Pierre, additional, Chabert, Emmanuel, additional, Bourgois, Nathalie, additional, Cornut-Chauvinc, Catherine, additional, Ferrier, Anna, additional, Gabrillargues, Jean, additional, Jean, Betty, additional, Marques, Anna-Raquel, additional, Vitello, Nicolas, additional, Detante, Olivier, additional, Barbieux, Marianne, additional, Boubagra, Kamel, additional, Favre Wiki, Isabelle, additional, Garambois, Katia, additional, Tahon, Florence, additional, Ashok, Vasdev, additional, Coskun, Oguzhan, additional, Rodesch, Georges, additional, Lapergue, Bertrand, additional, Bourdain, Frédéric, additional, Evrard, Serge, additional, Graveleau, Philippe, additional, Decroix, Jean Pierre, additional, Wang, Adrien, additional, Sellal, François, additional, Ahle, Guido, additional, Carelli, Gabriela, additional, Dugay, Marie-Hélène, additional, Gaultier, Claude, additional, Lebedinsky, Ariel Pablo, additional, Lita, Lavinia, additional, Musacchio, Raul Mariano, additional, Renglewicz-Destuynder, Catherine, additional, Tournade, Alain, additional, Vuillemet, Françis, additional, Montoro, Francisco Macian, additional, Mounayer, Charbel, additional, Faugeras, Frederic, additional, Gimenez, Laetitia, additional, Labach, Catherine, additional, Lautrette, Géraldine, additional, Denier, Christian, additional, Saliou, Guillaume, additional, Chassin, Olivier, additional, Dussaule, Claire, additional, Melki, Elsa, additional, Ozanne, Augustin, additional, Puccinelli, Francesco, additional, Sachet, Marina, additional, Sarov, Mariana, additional, Bonneville, Jean-François, additional, Moulin, Thierry, additional, Biondi, Alessandra, additional, De Bustos Medeiros, Elisabeth, additional, Vuillier, Fabrice, additional, Courtheoux, Patrick, additional, Viader, Fausto, additional, Apoil-Brissard, Marion, additional, Bataille, Mathieu, additional, Bonnet, Anne-Laure, additional, Cogez, Julien, additional, Touze, Emmanuel, additional, Leclerc, Xavier, additional, Leys, Didier, additional, Aggour, Mohamed, additional, Aguettaz, Pierre, additional, Bodenant, Marie, additional, Cordonnier, Charlotte, additional, Deplanque, Dominique, additional, Girot, Marie, additional, Henon, Hilde, additional, Kalsoum, Erwah, additional, Lucas, Christian, additional, Pruvo, Jean-Pierre, additional, Zuniga, Paolo, additional, Arquizan, Caroline, additional, Costalat, Vincent, additional, Machi, Paolo, additional, Mourand, Isabelle, additional, Riquelme, Carlos, additional, Bounolleau, Pierre, additional, Arteaga, Charles, additional, Faivre, Anthony, additional, Bintner, Marc, additional, Tournebize, Patrice, additional, Charlin, Cyril, additional, Darcel, Françoise, additional, Gauthier-Lasalarie, Pascale, additional, Jeremenko, Marcia, additional, Mouton, Servane, additional, Zerlauth, Jean-Baptiste, additional, Lamy, Chantal, additional, Hervé, Deramond, additional, Hassan, Hosseini, additional, Gaston, André, additional, Barral, Francis-Guy, additional, Garnier, Pierre, additional, Beaujeux, Rémy, additional, Wolff, Valérie, additional, Herbreteau, Denis, additional, Debiais, Séverine, additional, Murray, Alicia, additional, Ford, Gary, additional, Clifton, Andy, additional, Freeman, Janet, additional, Ford, Ian, additional, Markus, Hugh, additional, Wardlaw, Joanna, additional, Molyneux, Andy, additional, Robinson, Thompson, additional, Lewis, Steff, additional, Norrie, John, additional, Robertson, Fergus, additional, Perry, Richard, additional, Dixit, Anand, additional, Clifton, Andrew, additional, Roffe, Christine, additional, Nayak, Sanjeev, additional, Lobotesis, Kyriakos, additional, Smith, Craig, additional, Herwadkar, Amit, additional, Kandasamy, Naga, additional, Goddard, Tony, additional, Bamford, John, additional, Subramanian, Ganesh, additional, Lenthall, Rob, additional, Littleton, Edward, additional, Lamin, Sal, additional, Storey, Kelley, additional, Ghatala, Rita, additional, Banaras, Azra, additional, Aeron-Thomas, John, additional, Hazel, Bath, additional, Maguire, Holly, additional, Veraque, Emelda, additional, Harrison, Louise, additional, Keshvara, Rekha, additional, and Cunningham, James, additional
Published: 2019
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14. Stent-Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke

Author: Saver, Jeffrey L, Goyal, Mayank, Bonafe, Alain, Diener, Hans Christoph, Levy, Elad I, Pereira, Vitor M, Albers, Gregory W, Cognard, Christophe, Cohen, David J, Hacke, Werner, Jansen, Olav, Jovin, Tudor G, Mattle, Heinrich P, Nogueira, Raul G, Siddiqui, Adnan H, Yavagal, Dileep R, Baxter, Blaise W, Devlin, Thomas G, Lopes, Demetrius K, Reddy, Vivek K, du Mesnil de Rochemont, Richard, Singer, Oliver C, Jahan, Reza, Devlin, T, Baxter, B, Hawk, H, Sapkota, B, Quarfordt, S, Sirelkhatim, A, Dellinger, C, Barton, K, Reddy, V K, Jovin, T G, Ducruet, A, Jadhav, A, Horev, A, Giurgiutiu, D-V, Totoraitis, V, Hammer, M, Jankowitz, B, Wechsler, L, Rocha, M, Gulati, D, Campbell, D, Star, M, Baxendell, L, Oakley, J, Siddiqui, A H, Hopkins, L N, Levy, E, Snyder, K, Sawyer, R, Hall, S, Bonafé, A, Costalat, V, Riquelme, C, Machi, P, Omer, E, Arquizan, C, Mourand, I, Charif, M, Ayrignac, X, de Champfleur, N Menjot, Leboucq, N, Gascou, G, Moynier, M, du Mesnil de Rochemont, R, Singer, O, Berkefeld, J, Foerch, C, Lorenz, M, Pfeilschifer, W, Hattingen, E, Wagner, M, You, S-J, Lescher, S, Braun, H, Nogueira, R G, Dehkharghani, S, Belagaje, S R, Anderson, A, Lima, A, Obideen, M, Haussen, D, Dharia, R, Frankel, M, Patel, V, Owada, K, Saad, A, Amerson, L, Horn, C, Doppelheuer, S, Schindler, K, Lopes, D K, Chen, M, Moftakhar, R, Anton, C, Smreczak, M, Carpenter, J S, Boo, S, Rai, A, Roberts, T, Tarabishy, A, Gutmann, L, Brooks, C, Brick, J, Domico, J, Reimann, G, Hinrichs, K, Becker, M, Heiss, E, Selle, C, Witteler, A, Al-Boutros, S, Danch, M-J, Ranft, A, Rohde, S, Burg, K, Weimar, C, Zegarac, V, Hartmann, C, Schlamann, Marc, Göricke, Sophia Luise, Ringlestein, A, Wanke, Isabel, Mönninghoff, Christoph, Dietzold, M, Budzik, R, Davis, T, Eubank, G, Hicks, W J, Pema, P, Vora, N, Mejilla, J, Taylor, M, Clark, W, Rontal, A, Fields, J, Peterson, B, Nesbit, G, Lutsep, H, Bozorgchami, H, Priest, R, Ologuntoye, O, Barnwell, S, Dogan, A, Herrick, K, Takahasi, C, Beadell, N, Brown, B, Jamieson, S, Hussain, M S, Russman, A, Hui, F, Wisco, D, Uchino, K, Khawaja, Z, Katzan, I, Toth, G, Cheng-Ching, E, Bain, M, Man, S, Farrag, A, George, P, John, S, Shankar, L, Drofa, A, Dahlgren, R, Bauer, A, Itreat, A, Taqui, A, Cerejo, R, Richmond, A, Ringleb, P, Bendszus, M, Möhlenbruch, M, Reiff, T, Amiri, H, Purrucker, J, Herweh, C, Pham, M, Menn, O, Ludwig, I, Acosta, I, Villar, C, Morgan, W, Sombutmai, C, Hellinger, F, Allen, E, Bellew, M, Gandhi, R, Bonwit, E, Aly, J, Ecker, R D, Seder, D, Morris, J, Skaletsky, M, Belden, J, Baker, C, Connolly, L S, Papanagiotou, P, Roth, C, Kastrup, A, Politi, M, Brunner, F, Alexandrou, M, Merdivan, H, Ramsey, C, Given, C, Renfrow, S, Deshmukh, V, Sasadeusz, K, Vincent, F, Thiesing, J T, Putnam, J, Bhatt, A, Kansara, A, Caceves, D, Lowenkopf, T, Yanase, L, Zurasky, J, Dancer, S, Freeman, B, Scheibe-Mirek, T, Robison, J, Roll, J, Clark, D, Rodriguez, M, Fitzsimmons, B-F M, Zaidat, O, Lynch, J R, Lazzaro, M, Larson, T, Padmore, L, Das, E, Farrow-Schmidt, A, Hassan, A, Tekle, W, Cate, C, Jansen, O, Cnyrim, C, Wodarg, F, Wiese, C, Binder, A, Riedel, C, Rohr, A, Lang, N, Laufs, H, Krieter, S, Remonda, L, Diepers, M, Añon, J, Nedeltchev, K, Kahles, T, Biethahn, S, Lindner, M, Chang, V, Gächter, C, Esperon, C, Guglielmetti, M, Lara, J F Arenillas, Galdámez, M Martínez, Sanz, A I Calleja, Garcia, E Cortijo, Bermejo, P Garcia, Perez, S, Carrillo, P Mulero, Vallejo, E Crespo, Piñero, M Ruiz, Mesonero, L Lopez, Muñoz, F J Reyes, Brekenfeld, C, Buhk, J-H, Krützelmann, A, Thomalla, G, Cheng, B, Beck, C, Hoppe, J, Goebell, E, Holst, B, Grzyska, U, Wortmann, G, Starkman, S, Duckwiler, G, Jahan, R, Rao, N, Sheth, S, Ng, K, Noorian, A, Szeder, V, Nour, M, McManus, M, Huang, J, Tarpley, J, Tateshima, S, Gonzalez, N, Ali, L, Liebeskind, D, Hinman, J, Calderon-Arnulphi, M, Liang, C, Guzy, J, Yavagal, D R, Koch, S, DeSousa, K, Gordon-Perue, G, Elhammady, M, Peterson, E, Pandey, V, Dharmadhikari, S, Khandelwal, P, Malik, A, Pafford, R, Gonzalez, P, Ramdas, K, Andersen, G, Damgaard, D, Von Weitzel-Mudersbach, P, Simonsen, C, Ayudarte, N Ruiz de Morales, Poulsen, M, Sørensen, L, Karabegovich, S, Hjørringgaard, M, Hjort, N, Harbo, T, Sørensen, K, Deshaies, E, Padalino, D, Swarnkar, A, Latorre, J G, Elnour, E, El-Zammar, Z, Villwock, M, Farid, H, Balgude, A, Cross, L, Hansen, K, Holtmannspötter, M, Kondziella, D, Hoejgaard, J, Taudorf, S, Soendergaard, H, Wagner, A, Cronquist, M, Stavngaard, T, Cortsen, M, Krarup, L H, Hyldal, T, Haring, H-P, Guggenberger, S, Hamberger, M, Trenkler, J, Sonnberger, M, Nussbaumer, K, Dominger, C, Bach, E, Jagadeesan, B D, Taylor, R, Kim, J, Shea, K, Tummala, R, Zacharatos, H, Sandhu, D, Ezzeddine, M, Grande, A, Hildebrandt, D, Miller, K, Scherber, J, Hendrickson, A, Jumaa, M, Zaidi, S, Hendrickson, T, Snyder, V, Killer-Oberpfalzer, M, Mutzenbach, J, Weymayr, F, Broussalis, E, Stadler, K, Jedlitschka, A, Malek, A, Mueller-Kronast, N, Beck, P, Martin, C, Summers, D, Day, J, Bettinger, I, Holloway, W, Olds, K, Arkin, S, Akhtar, N, Boutwell, C, Crandall, S, Schwartzman, M, Weinstein, C, Brion, B, Prothmann, S, Kleine, J, Kreiser, K, Boeckh-Behrens, T, Poppert, H, Wunderlich, S, Koch, M L, Biberacher, V, Huberle, A, Gora-Stahlberg, G, Knier, B, Meindl, T, Utpadel-Fischler, D, Zech, M, Kowarik, M, Seifert, C, Schwaiger, B, Puri, A, Hou, S, Wakhloo, A, Moonis, M, Henniger, N, Goddeau, R, Massari, F, Minaeian, A, Lozano, J D, Ramzan, M, Stout, C, Patel, A, Tunguturi, A, Onteddu, S, Carandang, R, Howk, M, University of California [Los Angeles] (UCLA), University of California, Département de Neuroradiologie[Montpellier], Hôpital Gui de Chauliac [Montpellier]-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), and CHU Toulouse [Toulouse]
Subjects: Male, medicine.medical_specialty, Solitaire Cryptographic Algorithm, Randomization, Medizin, 610 Medicine & health, Brain Ischemia, law.invention, Fibrinolytic Agents, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Randomized controlled trial, Modified Rankin Scale, law, medicine, Humans, Intravenous tissue plasminogen activator, Stroke, Aged, Thrombectomy, Stent retriever, Groin, business.industry, Endovascular Procedures, General Medicine, Middle Aged, medicine.disease, Combined Modality Therapy, 3. Good health, Surgery, Treatment Outcome, medicine.anatomical_structure, Tissue Plasminogen Activator, Acute Disease, Administration, Intravenous, Female, Stents, business
Abstract: BACKGROUND: Among patients with acute ischemic stroke due to occlusions in the proximal anterior intracranial circulation, less than 40% regain functional independence when treated with intravenous tissue plasminogen activator (t-PA) alone. Thrombectomy with the use of a stent retriever, in addition to intravenous t-PA, increases reperfusion rates and may improve long-term functional outcome.METHODS: We randomly assigned eligible patients with stroke who were receiving or had received intravenous t-PA to continue with t-PA alone (control group) or to undergo endovascular thrombectomy with the use of a stent retriever within 6 hours after symptom onset (intervention group). Patients had confirmed occlusions in the proximal anterior intracranial circulation and an absence of large ischemic-core lesions. The primary outcome was the severity of global disability at 90 days, as assessed by means of the modified Rankin scale (with scores ranging from 0 [no symptoms] to 6 [death]).RESULTS: The study was stopped early because of efficacy. At 39 centers, 196 patients underwent randomization (98 patients in each group). In the intervention group, the median time from qualifying imaging to groin puncture was 57 minutes, and the rate of substantial reperfusion at the end of the procedure was 88%. Thrombectomy with the stent retriever plus intravenous t-PA reduced disability at 90 days over the entire range of scores on the modified Rankin scale (PCONCLUSIONS: In patients receiving intravenous t-PA for acute ischemic stroke due to occlusions in the proximal anterior intracranial circulation, thrombectomy with a stent retriever within 6 hours after onset improved functional outcomes at 90 days. (Funded by Covidien; SWIFT PRIME ClinicalTrials.gov number, NCT01657461.).
Published: 2015

15. Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data

Author: Román, Luis San, primary, Menon, Bijoy K, additional, Blasco, Jordi, additional, Hernández-Pérez, María, additional, Dávalos, Antoni, additional, Majoie, Charles B L M, additional, Campbell, Bruce C V, additional, Guillemin, Francis, additional, Lingsma, Hester, additional, Anxionnat, René, additional, Epstein, Jonathan, additional, Saver, Jeffrey L, additional, Marquering, Henk, additional, Wong, John H, additional, Lopes, Demetrius, additional, Reimann, Gernot, additional, Desal, Hubert, additional, Dippel, Diederik W J, additional, Coutts, Shelagh, additional, du Mesnil de Rochemont, Richard, additional, Yavagal, Dileep, additional, Ferre, Jean Christophe, additional, Roos, Yvo B W E M, additional, Liebeskind, David S, additional, Lenthall, Robert, additional, Molina, Carlos, additional, Al Ajlan, Fahad S, additional, Reddy, Vivek, additional, Dowlatshahi, Dar, additional, Sourour, Nader-Antoine, additional, Oppenheim, Catherine, additional, Mitha, Alim P, additional, Davis, Stephen M, additional, Weimar, Christian, additional, van Oostenbrugge, Robert J, additional, Cobo, Erik, additional, Kleinig, Timothy J, additional, Donnan, Geoffrey A, additional, van der Lugt, Aad, additional, Demchuk, Andrew M, additional, Berkhemer, Olvert A, additional, Boers, Anna M M, additional, Ford, Gary A, additional, Muir, Keith W, additional, Brown, B Scott, additional, Jovin, Tudor, additional, van Zwam, Wim H, additional, Mitchell, Peter J, additional, Hill, Michael D, additional, White, Phil, additional, Bracard, Serge, additional, Goyal, Mayank, additional, Fransen, Puck SS, additional, Beumer, Debbie, additional, van den Berg, Lucie A, additional, Lingsma, Hester F, additional, Yoo, Albert J, additional, Schonewille, Wouter J, additional, Vos, Jan Albert, additional, Nederkoorn, Paul J, additional, Wermer, Marieke JH, additional, van Walderveen, Marianne AA, additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, van Oostayen, Jacques A., additional, Lycklama à Nijeholt, Geert J., additional, Boiten, Jelis, additional, Brouwer, Patrick A., additional, Emmer, Bart J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Kappelle, Jaap, additional, Lo, Rob H, additional, van Dijk, Ewoud J., additional, de Vries, Joost, additional, de Kort, Paul L.M., additional, van Rooij, Willem Jan J., additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Visser, Marieke C., additional, Bot, Joseph C.J., additional, Vroomen, Patrick C., additional, Eshghi, Omid, additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Tielbeek, Alexander V., additional, den Hertog, Heleen M., additional, Gerrits, Dick G., additional, van den Berg-Vos, Renske M., additional, Karas, Giorgos B., additional, Steyerberg, Ewout W., additional, Flach, Zwenneke, additional, Marquering, Henk A., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, Beenen, Ludo F.M., additional, van den Berg, René, additional, Koudstaal, Peter J., additional, van Zwam, Wim H., additional, Roos, Yvo B.W.E.M., additional, van Oostenbrugge, Robert J., additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, Brown, Martin M., additional, Liebig, Thomas, additional, Stijnen, Theo, additional, Andersson, Tommy, additional, Mattle, Heinrich, additional, Wahlgren, Nils, additional, van der Heijden, Esther, additional, Ghannouti, Naziha, additional, Fleitour, Nadine, additional, Hooijenga, Imke, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Geerling, Annet, additional, Lindl-Velema, Annemieke, additional, van Vemde, Gina, additional, de Ridder, Ans, additional, Greebe, Paut, additional, de Bont-Stikkelbroeck, José, additional, de Meris, Joke, additional, Janssen, Kirsten, additional, Struijk, Willy, additional, Licher, Silvan, additional, Boodt, Nikki, additional, Ros, Adriaan, additional, Venema, Esmee, additional, Slokkers, Ilse, additional, Ganpat, Raymie-Jayce, additional, Mulder, Maxim, additional, Saiedie, Nawid, additional, Heshmatollah, Alis, additional, Schipperen, Stefanie, additional, Vinken, Stefan, additional, van Boxtel, Tiemen, additional, Koets, Jeroen, additional, Boers, Merel, additional, Santos, Emilie, additional, Borst, Jordi, additional, Jansen, Ivo, additional, Kappelhof, Manon, additional, Lucas, Marit, additional, Geuskens, Ralph, additional, Barros, Renan Sales, additional, Dobbe, Roeland, additional, Csizmadia, Marloes, additional, Hill, MD, additional, Goyal, M, additional, Demchuk, AM, additional, Menon, BK, additional, Eesa, M, additional, Ryckborst, KJ, additional, Wright, MR, additional, Kamal, NR, additional, Andersen, L, additional, Randhawa, PA, additional, Stewart, T, additional, Patil, S, additional, Minhas, P, additional, Almekhlafi, M, additional, Mishra, S, additional, Clement, F, additional, Sajobi, T, additional, Shuaib, A, additional, Montanera, WJ, additional, Roy, D, additional, Silver, FL, additional, Jovin, TG, additional, Frei, DF, additional, Sapkota, B, additional, Rempel, JL, additional, Thornton, J, additional, Williams, D, additional, Tampieri, D, additional, Poppe, AY, additional, Dowlatshahi, D, additional, Wong, JH, additional, Mitha, AP, additional, Subramaniam, S, additional, Hull, G, additional, Lowerison, MW, additional, Salluzzi, M, additional, Maxwell, M, additional, Lacusta, S, additional, Drupals, E, additional, Armitage, K, additional, Barber, PA, additional, Smith, EE, additional, Morrish, WF, additional, Coutts, SB, additional, Derdeyn, C, additional, Demaerschalk, B, additional, Yavagal, D, additional, Martin, R, additional, Brant, R, additional, Yu, Y, additional, Willinsky, RA, additional, Weill, A, additional, Kenney, C, additional, Aram, H, additional, Stys, PK, additional, Watson, TW, additional, Klein, G, additional, Pearson, D, additional, Couillard, P, additional, Trivedi, A, additional, Singh, D, additional, Klourfeld, E, additional, Imoukhuede, O, additional, Nikneshan, D, additional, Blayney, S, additional, Reddy, R, additional, Choi, P, additional, Horton, M, additional, Musuka, T, additional, Dubuc, V, additional, Field, TS, additional, Desai, J, additional, Adatia, S, additional, Alseraya, A, additional, Nambiar, V, additional, van Dijk, R, additional, Newcommon, NJ, additional, Schwindt, B, additional, Butcher, KS, additional, Jeerakathil, T, additional, Buck, B, additional, Khan, K, additional, Naik, SS, additional, Emery, DJ, additional, Owen, RJ, additional, Kotylak, TB, additional, Ashforth, RA, additional, Yeo, TA, additional, McNally, D, additional, Siddiqui, M, additional, Saqqur, M, additional, Hussain, D, additional, Kalashyan, H, additional, Manosalva, A, additional, Kate, M, additional, Gioia, L, additional, Hasan, S, additional, Mohammad, A, additional, Muratoglu, M, additional, Cullen, A, additional, Brennan, P, additional, O'Hare, A, additional, Looby, S, additional, Hyland, D, additional, Duff, S, additional, McCusker, M, additional, Hallinan, B, additional, Lee, S, additional, McCormack, J, additional, Moore, A, additional, O'Connor, M, additional, Donegan, C, additional, Brewer, L, additional, Martin, A, additional, Murphy, S, additional, O'Rourke, K, additional, Smyth, S, additional, Kelly, P, additional, Lynch, T, additional, Daly, T, additional, O'Brien, P, additional, O'Driscoll, A, additional, Martin, M, additional, Collins, R, additional, Coughlan, T, additional, McCabe, D, additional, O'Neill, D, additional, Mulroy, M, additional, Lynch, O, additional, Walsh, T, additional, O'Donnell, M, additional, Galvin, T, additional, Harbison, J, additional, McElwaine, P, additional, Mulpeter, K, additional, McLoughlin, C, additional, Reardon, M, additional, Harkin, E, additional, Dolan, E, additional, Watts, M, additional, Cunningham, N, additional, Fallon, C, additional, Gallagher, S, additional, Cotter, P, additional, Crowe, M, additional, Doyle, R, additional, Noone, I, additional, Lapierre, M, additional, Coté, VA, additional, Lanthier, S, additional, Odier, C, additional, Durocher, A, additional, Raymond, J, additional, Daneault, N, additional, Deschaintre, Y, additional, Jankowitz, B, additional, Baxendell, L, additional, Massaro, L, additional, Jackson-Graves, C, additional, Decesare, S, additional, Porter, P, additional, Armbruster, K, additional, Adams, A, additional, Billigan, J, additional, Oakley, J, additional, Ducruet, A, additional, Jadhav, A, additional, Giurgiutiu, D-V, additional, Aghaebrahim, A, additional, Reddy, V, additional, Hammer, M, additional, Starr, M, additional, Totoraitis, V, additional, Wechsler, L, additional, Streib, S, additional, Rangaraju, S, additional, Campbell, D, additional, Rocha, M, additional, Gulati, D, additional, Krings, T, additional, Kalman, L, additional, Cayley, A, additional, Williams, J, additional, Wiegner, R, additional, Casaubon, LK, additional, Jaigobin, C, additional, del Campo, JM, additional, Elamin, E, additional, Schaafsma, JD, additional, Agid, R, additional, Farb, R, additional, ter Brugge, K, additional, Sapkoda, BL, additional, Baxter, BW, additional, Barton, K, additional, Knox, A, additional, Porter, A, additional, Sirelkhatim, A, additional, Devlin, T, additional, Dellinger, C, additional, Pitiyanuvath, N, additional, Patterson, J, additional, Nichols, J, additional, Quarfordt, S, additional, Calvert, J, additional, Hawk, H, additional, Fanale, C, additional, Bitner, A, additional, Novak, A, additional, Huddle, D, additional, Bellon, R, additional, Loy, D, additional, Wagner, J, additional, Chang, I, additional, Lampe, E, additional, Spencer, B, additional, Pratt, R, additional, Bartt, R, additional, Shine, S, additional, Dooley, G, additional, Nguyen, T, additional, Whaley, M, additional, McCarthy, K, additional, Teitelbaum, J, 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Published: 2018
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16. Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

Author: Campbell, Bruce C V, primary, van Zwam, Wim H, additional, Goyal, Mayank, additional, Menon, Bijoy K, additional, Dippel, Diederik W J, additional, Demchuk, Andrew M, additional, Bracard, Serge, additional, White, Philip, additional, Dávalos, Antoni, additional, Majoie, Charles B L M, additional, van der Lugt, Aad, additional, Ford, Gary A, additional, de la Ossa, Natalia Pérez, additional, Kelly, Michael, additional, Bourcier, Romain, additional, Donnan, Geoffrey A, additional, Roos, Yvo B W E M, additional, Bang, Oh Young, additional, Nogueira, Raul G, additional, Devlin, Thomas G, additional, van den Berg, Lucie A, additional, Clarençon, Frédéric, additional, Burns, Paul, additional, Carpenter, Jeffrey, additional, Berkhemer, Olvert A, additional, Yavagal, Dileep R, additional, Pereira, Vitor Mendes, additional, Ducrocq, Xavier, additional, Dixit, Anand, additional, Quesada, Helena, additional, Epstein, Jonathan, additional, Davis, Stephen M, additional, Jansen, Olav, additional, Rubiera, Marta, additional, Urra, Xabier, additional, Micard, Emilien, additional, Lingsma, Hester F, additional, Naggara, Olivier, additional, Brown, Scott, additional, Guillemin, Francis, additional, Muir, Keith W, additional, van Oostenbrugge, Robert J, additional, Saver, Jeffrey L, additional, Jovin, Tudor G, additional, Hill, Michael D, additional, Mitchell, Peter J, additional, Fransen, Puck SS, additional, Beumer, Debbie, additional, Yoo, Albert J, additional, Schonewille, Wouter J, additional, Vos, Jan Albert, additional, Nederkoorn, Paul J, additional, Wermer, Marieke JH, additional, van Walderveen, Marianne AA, additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, van Oostayen, Jacques A., additional, Lycklama à Nijeholt, Geert J., additional, Boiten, Jelis, additional, Brouwer, Patrick A., additional, Emmer, Bart J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Kappelle, Jaap, additional, Lo, Rob H, additional, van Dijk, Ewoud J., additional, de Vries, Joost, additional, de Kort, Paul L.M., additional, van Rooij, Willem Jan J., additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Visser, Marieke C., additional, Bot, Joseph C.J., additional, Vroomen, Patrick C., additional, Eshghi, Omid, additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Tielbeek, Alexander V., additional, den Hertog, Heleen M., additional, Gerrits, Dick G., additional, van den Berg-Vos, Renske M., additional, Karas, Giorgos B., additional, Steyerberg, Ewout W., additional, Flach, Zwenneke, additional, Marquering, Henk A., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, Beenen, Ludo F.M., additional, van den Berg, René, additional, Koudstaal, Peter J., additional, van Zwam, Wim H., additional, Roos, Yvo B.W.E.M., additional, van Oostenbrugge, Robert J., additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, Brown, Martin M., additional, Liebig, Thomas, additional, Stijnen, Theo, additional, Andersson, Tommy, additional, Mattle, Heinrich, additional, Wahlgren, Nils, additional, van der Heijden, Esther, additional, Ghannouti, Naziha, additional, Fleitour, Nadine, additional, Hooijenga, Imke, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Geerling, Annet, additional, Lindl-Velema, Annemieke, additional, van Vemde, Gina, additional, de Ridder, Ans, additional, Greebe, Paut, additional, de Bont-Stikkelbroeck, José, additional, de Meris, Joke, additional, Janssen, Kirsten, additional, Struijk, Willy, additional, Licher, Silvan, additional, Boodt, Nikki, additional, Ros, Adriaan, additional, Venema, Esmee, additional, Slokkers, Ilse, additional, Ganpat, Raymie-Jayce, additional, Mulder, Maxim, additional, Saiedie, Nawid, additional, Heshmatollah, Alis, additional, Schipperen, Stefanie, additional, Vinken, Stefan, additional, van Boxtel, Tiemen, additional, Koets, Jeroen, additional, Boers, Merel, additional, Santos, Emilie, additional, Borst, Jordi, additional, Jansen, Ivo, additional, Kappelhof, Manon, additional, Lucas, Marit, additional, Geuskens, Ralph, additional, Barros, Renan Sales, additional, Dobbe, Roeland, additional, Csizmadia, Marloes, additional, Hill, MD, additional, Goyal, M, additional, Demchuk, AM, additional, Menon, BK, additional, Eesa, M, additional, Ryckborst, KJ, additional, Wright, MR, additional, Kamal, NR, additional, Andersen, L, additional, Randhawa, PA, additional, Stewart, T, additional, Patil, S, additional, Minhas, P, additional, Almekhlafi, M, additional, Mishra, S, additional, Clement, F, additional, Sajobi, T, additional, Shuaib, A, additional, Montanera, WJ, additional, Roy, D, additional, Silver, FL, additional, Jovin, TG, additional, Frei, DF, additional, Sapkota, B, additional, Rempel, JL, additional, Thornton, J, additional, Williams, D, additional, Tampieri, D, additional, Poppe, AY, additional, Dowlatshahi, D, additional, Wong, JH, additional, Mitha, AP, additional, Subramaniam, S, additional, Hull, G, additional, Lowerison, MW, additional, Salluzzi, M, additional, Maxwell, M, additional, Lacusta, S, additional, Drupals, E, additional, Armitage, K, additional, Barber, PA, additional, Smith, EE, additional, Morrish, WF, additional, Coutts, SB, additional, Derdeyn, C, additional, Demaerschalk, B, additional, Yavagal, D, additional, Martin, R, additional, Brant, R, additional, Yu, Y, additional, Willinsky, RA, additional, Weill, A, additional, Kenney, C, additional, Aram, H, additional, Stys, PK, additional, Watson, TW, additional, Klein, G, additional, Pearson, D, additional, Couillard, P, additional, Trivedi, A, additional, Singh, D, additional, Klourfeld, E, additional, Imoukhuede, O, additional, Nikneshan, D, additional, Blayney, S, additional, Reddy, R, additional, Choi, P, additional, Horton, M, additional, Musuka, T, additional, Dubuc, V, additional, Field, TS, additional, Desai, J, additional, Adatia, S, additional, Alseraya, A, additional, Nambiar, V, additional, van Dijk, R, additional, Newcommon, NJ, additional, Schwindt, B, additional, Butcher, KS, additional, Jeerakathil, T, additional, Buck, B, additional, Khan, K, additional, Naik, SS, additional, Emery, DJ, additional, Owen, RJ, additional, Kotylak, TB, additional, Ashforth, RA, additional, Yeo, TA, additional, McNally, D, additional, Siddiqui, M, additional, Saqqur, M, additional, Hussain, D, additional, Kalashyan, H, additional, Manosalva, A, additional, Kate, M, additional, Gioia, L, additional, Hasan, S, additional, Mohammad, A, additional, Muratoglu, M, additional, Cullen, A, additional, Brennan, P, additional, O'Hare, A, additional, Looby, S, additional, Hyland, D, additional, Duff, S, additional, McCusker, M, additional, Hallinan, B, additional, Lee, S, additional, McCormack, J, additional, Moore, A, additional, O'Connor, M, additional, Donegan, C, additional, Brewer, L, additional, Martin, A, additional, Murphy, S, additional, O'Rourke, K, additional, Smyth, S, additional, Kelly, P, additional, Lynch, T, additional, Daly, T, additional, O'Brien, P, additional, O'Driscoll, A, additional, Martin, M, additional, Collins, R, additional, Coughlan, T, additional, McCabe, D, additional, O'Neill, D, additional, Mulroy, M, additional, Lynch, O, additional, Walsh, T, additional, O'Donnell, M, additional, Galvin, T, additional, Harbison, J, additional, McElwaine, P, additional, Mulpeter, K, additional, McLoughlin, C, additional, Reardon, M, additional, Harkin, E, additional, Dolan, E, additional, Watts, M, additional, Cunningham, N, additional, Fallon, C, additional, Gallagher, S, additional, Cotter, P, additional, Crowe, M, additional, Doyle, R, additional, Noone, I, additional, Lapierre, M, additional, Coté, VA, additional, Lanthier, S, additional, Odier, C, additional, Durocher, A, additional, Raymond, J, additional, Daneault, N, additional, Deschaintre, Y, additional, Jankowitz, B, additional, Baxendell, L, additional, Massaro, L, additional, Jackson-Graves, C, additional, Decesare, S, additional, Porter, P, additional, Armbruster, K, additional, Adams, A, additional, Billigan, J, additional, Oakley, J, additional, Ducruet, A, additional, Jadhav, A, additional, Giurgiutiu, D-V, additional, Aghaebrahim, A, additional, Reddy, V, additional, Hammer, M, additional, Starr, M, additional, Totoraitis, V, additional, Wechsler, L, additional, Streib, S, additional, Rangaraju, S, additional, Campbell, D, additional, Rocha, M, additional, Gulati, D, additional, Krings, T, additional, Kalman, L, additional, Cayley, A, additional, Williams, J, additional, Wiegner, R, additional, Casaubon, LK, additional, Jaigobin, C, additional, del Campo, JM, additional, Elamin, E, additional, Schaafsma, JD, additional, Agid, R, additional, Farb, R, additional, ter Brugge, K, additional, Sapkoda, BL, additional, Baxter, BW, additional, Barton, K, additional, Knox, A, additional, Porter, A, additional, Sirelkhatim, A, additional, Devlin, T, additional, Dellinger, C, additional, Pitiyanuvath, N, additional, Patterson, J, additional, Nichols, J, additional, Quarfordt, S, additional, Calvert, J, additional, Hawk, H, additional, Fanale, C, additional, Bitner, A, additional, Novak, A, additional, Huddle, D, additional, Bellon, R, additional, Loy, D, additional, Wagner, J, additional, Chang, I, additional, Lampe, E, additional, Spencer, B, additional, Pratt, R, additional, Bartt, R, additional, Shine, S, additional, Dooley, G, additional, Nguyen, T, additional, Whaley, M, additional, McCarthy, K, additional, Teitelbaum, J, additional, Poon, W, additional, Campbell, N, additional, Cortes, M, additional, Lum, C, additional, Shamloul, R, additional, Robert, S, additional, Stotts, G, additional, Shamy, M, additional, Steffenhagen, N, additional, Blacquiere, D, additional, Hogan, M, additional, AlHazzaa, M, additional, Basir, G, additional, Lesiuk, H, additional, Iancu, D, additional, Santos, M, additional, Choe, H, additional, Weisman, DC, additional, Jonczak, K, additional, Blue-Schaller, A, additional, Shah, Q, additional, MacKenzie, L, additional, Klein, B, additional, Kulandaivel, K, additional, Kozak, O, additional, Gzesh, DJ, additional, Harris, LJ, additional, Khoury, JS, additional, Mandzia, J, additional, Pelz, D, additional, Crann, S, additional, Fleming, L, additional, Hesser, K, additional, Beauchamp, B, additional, Amato-Marzialli, B, additional, Boulton, M, additional, Lopez- Ojeda, P, additional, Sharma, M, additional, Lownie, S, additional, Chan, R, additional, Swartz, R, additional, Howard, P, additional, Golob, D, additional, Gladstone, D, additional, Boyle, K, additional, Boulos, M, additional, Hopyan, J, additional, Yang, V, additional, Da Costa, L, additional, Holmstedt, CA, additional, Turk, AS, additional, Navarro, R, additional, Jauch, E, additional, Ozark, S, additional, Turner, R, additional, Phillips, S, additional, Shankar, J, additional, Jarrett, J, additional, Gubitz, G, additional, Maloney, W, additional, Vandorpe, R, additional, Schmidt, M, additional, Heidenreich, J, additional, Hunter, G, additional, Kelly, M, additional, Whelan, R, additional, Peeling, L, additional, Burns, PA, additional, Hunter, A, additional, Wiggam, I, additional, Kerr, E, additional, Watt, M, additional, Fulton, A, additional, Gordon, P, additional, Rennie, I, additional, Flynn, P, additional, Smyth, G, additional, O'Leary, S, additional, Gentile, N, additional, Linares, G, additional, McNelis, P, additional, Erkmen, K, additional, Katz, P, additional, Azizi, A, additional, Weaver, M, additional, Jungreis, C, additional, Faro, S, additional, Shah, P, additional, Reimer, H, additional, Kalugdan, V, additional, Saposnik, G, additional, Bharatha, A, additional, Li, Y, additional, Kostyrko, P, additional, Marotta, T, additional, Montanera, W, additional, Sarma, D, additional, Selchen, D, additional, Spears, J, additional, Heo, JH, additional, Jeong, K, additional, Kim, DJ, additional, Kim, BM, additional, Kim, YD, additional, Song, D, additional, Lee, K-J, additional, Yoo, J, additional, Bang, OY, additional, Rho, S, additional, Lee, J, additional, Jeon, P, additional, Kim, KH, additional, Cha, J, additional, Kim, SJ, additional, Ryoo, S, additional, Lee, MJ, additional, Sohn, S-I, additional, Kim, C-H, additional, Ryu, H-G, additional, Hong, J-H, additional, Chang, H-W, additional, Lee, C-Y, additional, Rha, J, additional, Campbell, Bruce CV, additional, Churilov, Leonid, additional, Yan, Bernard, additional, Dowling, Richard, additional, Yassi, Nawaf, additional, Oxley, Thomas J, additional, Wu, Teddy Y, additional, Silver, Gabriel, additional, McDonald, Amy, additional, McCoy, Rachael, additional, Kleinig, Timothy J, additional, Scroop, Rebecca, additional, Dewey, Helen M, additional, Simpson, Marion, additional, Brooks, Mark, additional, Coulton, Bronwyn, additional, Krause, Martin, additional, Harrington, Timothy J, additional, Steinfort, Brendan, additional, Faulder, Kenneth, additional, Priglinger, Miriam, additional, Day, Susan, additional, Phan, Thanh, additional, Chong, Winston, additional, Holt, Michael, additional, Chandra, Ronil V, additional, Ma, Henry, additional, Young, Dennis, additional, Wong, Kitty, additional, Wijeratne, Tissa, additional, Tu, Hans, additional, Mackay, Elizabeth, additional, Celestino, Sherisse, additional, Bladin, Christopher F, additional, Loh, Poh Sien, additional, Gilligan, Amanda, additional, Ross, Zofia, additional, Coote, Skye, additional, Frost, Tanya, additional, Parsons, Mark W, additional, Miteff, Ferdinand, additional, Levi, Christopher R, additional, Ang, Timothy, additional, Spratt, Neil, additional, Kaauwai, Lara, additional, Badve, Monica, additional, Rice, Henry, additional, de Villiers, Laetitia, additional, Barber, P. Alan, additional, McGuinness, Ben, additional, Hope, Ayton, additional, Moriarty, Maurice, additional, Bennett, Patricia, additional, Wong, Andrew, additional, Coulthard, Alan, additional, Lee, Andrew, additional, Jannes, Jim, additional, Field, Deborah, additional, Sharma, Gagan, additional, Salinas, Simon, additional, Cowley, Elise, additional, Snow, Barry, additional, Kolbe, John, additional, Stark, Richard, additional, King, John, additional, Macdonnell, Richard, additional, Attia, John, additional, D'Este, Cate, additional, Diener, Hans-Christoph, additional, Levy, Elad I., additional, Bonafé, Alain, additional, Mendes Pereira, Vitor, additional, Jahan, Reza, additional, Albers, Gregory W., additional, Cognard, Christophe, additional, Cohen, David J., additional, Hacke, Werner, additional, Jovin, Tudor G., additional, Mattle, Heinrich P., additional, Nogueira, Raul G., additional, Siddiqui, Adnan H., additional, Yavagal, Dileep R., additional, von Kummer, Rüdiger, additional, Smith, Wade, additional, Turjman, Francis, additional, Hamilton, Scott, additional, Chiacchierini, Richard, additional, Amar, Arun, additional, Sanossian, Nerses, additional, Loh, Yince, additional, Baxter, B, additional, Reddy, VK, additional, Horev, A, additional, Star, M, additional, Siddiqui, A, additional, Hopkins, LN, additional, Snyder, K, additional, Sawyer, R, additional, Hall, S, additional, Costalat, V, additional, Riquelme, C, additional, Machi, P, additional, Omer, E, additional, Arquizan, C, additional, Mourand, I, additional, Charif, M, additional, Ayrignac, X, additional, Menjot de Champfleur, N, additional, Leboucq, N, additional, Gascou, G, additional, Moynier, M, additional, du Mesnil de Rochemont, R, additional, Singer, O, additional, Berkefeld, J, additional, Foerch, C, additional, Lorenz, M, additional, Pfeilschifer, W, additional, Hattingen, E, additional, Wagner, M, additional, You, SJ, additional, Lescher, S, additional, Braun, H, additional, Dehkharghani, S, additional, Belagaje, SR, additional, Anderson, A, additional, Lima, A, additional, Obideen, M, additional, Haussen, D, additional, Dharia, R, additional, Frankel, M, additional, Patel, V, additional, Owada, K, additional, Saad, A, additional, Amerson, L, additional, Horn, C, additional, Doppelheuer, S, additional, Schindler, K, additional, Lopes, DK, additional, Chen, M, additional, Moftakhar, R, additional, Anton, C, additional, Smreczak, M, additional, Carpenter, JS, additional, Boo, S, additional, Rai, A, additional, Roberts, T, additional, Tarabishy, A, additional, Gutmann, L, additional, Brooks, C, additional, Brick, J, additional, Domico, J, additional, Reimann, G, additional, Hinrichs, K, additional, Becker, M, additional, Heiss, E, additional, Selle, C, additional, Witteler, A, additional, Al-Boutros, S, additional, Danch, M-J, additional, Ranft, A, additional, Rohde, S, additional, Burg, K, additional, Weimar, C, additional, Zegarac, V, additional, Hartmann, C, additional, Schlamann, M, additional, Göricke, S, additional, Ringlestein, A, additional, Wanke, I, additional, Mönninghoff, C, additional, Dietzold, M, additional, Budzik, R, additional, Davis, T, additional, Eubank, G, additional, Hicks, WJ, additional, Pema, P, additional, Vora, N, additional, Mejilla, J, additional, Taylor, M, additional, Clark, W, additional, Rontal, A, additional, Fields, J, additional, Peterson, B, additional, Nesbit, G, additional, Lutsep, H, additional, Bozorgchami, H, additional, Priest, R, additional, Ologuntoye, O, additional, Barnwell, S, additional, Dogan, A, additional, Herrick, K, additional, Takahasi, C, additional, Beadell, N, additional, Brown, B, additional, Jamieson, S, additional, Hussain, MS, additional, Russman, A, additional, Hui, F, additional, Wisco, D, additional, Uchino, K, additional, Khawaja, Z, additional, Katzan, I, additional, Toth, G, additional, Cheng-Ching, E, additional, Bain, M, additional, Man, S, additional, Farrag, A, additional, George, P, additional, John, S, additional, Shankar, L, additional, Drofa, A, additional, Dahlgren, R, additional, Bauer, A, additional, Itreat, A, additional, Taqui, A, additional, Cerejo, R, additional, Richmond, A, additional, Ringleb, P, additional, Bendszus, M, additional, Möhlenbruch, M, additional, Reiff, T, additional, Amiri, H, additional, Purrucker, J, additional, Herweh, C, additional, Pham, M, additional, Menn, O, additional, Ludwig, I, additional, Acosta, I, additional, Villar, C, additional, Morgan, W, additional, Sombutmai, C, additional, Hellinger, F, additional, Allen, E, additional, Bellew, M, additional, Gandhi, R, additional, Bonwit, E, additional, Aly, J, additional, Ecker, RD, additional, Seder, D, additional, Morris, J, additional, Skaletsky, M, additional, Belden, J, additional, Baker, C, additional, Connolly, LS, additional, Papanagiotou, P, additional, Roth, C, additional, Kastrup, A, additional, Politi, M, additional, Brunner, F, additional, Alexandrou, M, additional, Merdivan, H, additional, Ramsey, C, additional, Given II, C, additional, Renfrow, S, additional, Deshmukh, V, additional, Sasadeusz, K, additional, Vincent, F, additional, Thiesing, JT, additional, Putnam, J, additional, Bhatt, A, additional, Kansara, A, additional, Caceves, D, additional, Lowenkopf, T, additional, Yanase, L, additional, Zurasky, J, additional, Dancer, S, additional, Freeman, B, additional, Scheibe-Mirek, T, additional, Robison, J, additional, Roll, J, additional, Clark, D, additional, Rodriguez, M, additional, Fitzsimmons, B-FM, additional, Zaidat, O, additional, Lynch, JR, additional, Lazzaro, M, additional, Larson, T, additional, Padmore, L, additional, Das, E, additional, Farrow-Schmidt, A, additional, Hassan, A, additional, Tekle, W, additional, Cate, C, additional, Jansen, O, additional, Cnyrim, C, additional, Wodarg, F, additional, Wiese, C, additional, Binder, A, additional, Riedel, C, additional, Rohr, A, additional, Lang, N, additional, Laufs, H, additional, Krieter, S, additional, Remonda, L, additional, Diepers, M, additional, Añon, J, additional, Nedeltchev, K, additional, Kahles, T, additional, Biethahn, S, additional, Lindner, M, additional, Chang, V, additional, Gächter, C, additional, Esperon, C, additional, Guglielmetti, M, additional, Arenillas Lara, JF, additional, Martínez Galdámez, M, additional, Calleja Sanz, AI, additional, Cortijo Garcia, E, additional, Garcia Bermejo, P, additional, Perez, S, additional, Mulero Carrillo, P, additional, Crespo Vallejo, E, additional, Ruiz Piñero, M, additional, Lopez Mesonero, L, additional, Reyes Muñoz, FJ, additional, Brekenfeld, C, additional, Buhk, J-H, additional, Krützelmann, A, additional, Thomalla, G, additional, Cheng, B, additional, Beck, C, additional, Hoppe, J, additional, Goebell, E, additional, Holst, B, additional, Grzyska, U, additional, Wortmann, G, additional, Starkman, S, additional, Duckwiler, G, additional, Jahan, R, additional, Rao, N, additional, Sheth, S, 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additional, Meindl, T, additional, Utpadel-Fischler, D, additional, Zech, M, additional, Kowarik, M, additional, Seifert, C, additional, Schwaiger, B, additional, Puri, A, additional, Hou, S, additional, Wakhloo, A, additional, Moonis, M, additional, Henninger, N, additional, Goddeau, R, additional, Massari, F, additional, Minaeian, A, additional, Lozano, JD, additional, Ramzan, M, additional, Stout, C, additional, Patel, A, additional, Tunguturi, A, additional, Onteddu, S, additional, Carandang, R, additional, Howk, M, additional, Ribó, M, additional, Sanjuan, E, additional, Rubiera, M, additional, Pagola, J, additional, Flores, A, additional, Muchada, M, additional, Meler, P, additional, Huerga, E, additional, Gelabert, S, additional, Coscojuela, P, additional, Tomasello, A, additional, Rodriguez, D, additional, Santamarina, E, additional, Maisterra, O, additional, Boned, S, additional, Seró, L, additional, Rovira, A, additional, Molina, CA, additional, Millán, M, additional, Muñoz, L, additional, Pérez de la Ossa, N, additional, Gomis, M, additional, Dorado, L, additional, López-Cancio, E, additional, Palomeras, E, additional, Munuera, J, additional, García Bermejo, P, additional, Remollo, S, additional, Castaño, C, additional, García-Sort, R, additional, Cuadras, P, additional, Puyalto, P, additional, Hernández-Pérez, M, additional, Jiménez, M, additional, Martínez-Piñeiro, A, additional, Lucente, G, additional, Dávalos, A, additional, Chamorro, A, additional, Urra, X, additional, Obach, V, additional, Cervera, A, additional, Amaro, S, additional, Llull, L, additional, Codas, J, additional, Balasa, M, additional, Navarro, J, additional, Ariño, H, additional, Aceituno, A, additional, Rudilosso, S, additional, Renu, A, additional, Macho, JM, additional, San Roman, L, additional, Blasco, J, additional, López, A, additional, Macías, N, additional, Cardona, P, additional, Quesada, H, additional, Rubio, F, additional, Cano, L, additional, Lara, B, additional, de Miquel, MA, additional, Aja, L, additional, Serena, J, additional, Cobo, E, additional, Albers, Gregory W, additional, Lees, Kennedy R, additional, Arenillas, J, additional, Roberts, R, additional, Al-Ajlan, F, additional, Zimmel, L, additional, Patel, S, additional, Martí-Fàbregas, J, additional, Salvat-Plana, M, additional, Bracard, S, additional, Anxionnat, René, additional, Baillot, Pierre-Alexandre, additional, Barbier, Charlotte, additional, Derelle, Anne-Laure, additional, Lacour, Jean-Christophe, additional, Richard, Sébastien, additional, Samson, Yves, additional, Sourour, Nader, additional, Baronnet-Chauvet, Flore, additional, Clarencon, Frédéric, additional, Crozier, Sophie, additional, Deltour, Sandrine, additional, Di Maria, Federico, additional, Le Bouc, Raphael, additional, Leger, Anne, additional, Mutlu, Gurkan, additional, Rosso, Charlotte, additional, Szatmary, Zoltan, additional, Yger, Marion, additional, Zavanone, Chiara, additional, Bakchine, Serge, additional, Pierot, Laurent, additional, Caucheteux, Nathalie, additional, Estrade, Laurent, additional, Kadziolka, Krzysztof, additional, Leautaud, Alexandre, additional, Renkes, Céline, additional, Serre, Isabelle, additional, Desal, Hubert, additional, Guillon, Benoît, additional, Boutoleau-Bretonniere, Claire, additional, Daumas-Duport, Benjamin, additional, De Gaalon, Solène, additional, Derkinderen, Pascal, additional, Evain, Sarah, additional, Herisson, Fanny, additional, Laplaud, David-Axel, additional, Lebouvier, Thibaud, additional, Lintia-Gaultier, Alina, additional, Pouclet-Courtemanche, Hélène, additional, Rouaud, Tiphaine, additional, Rouaud Jaffrenou, Violaine, additional, Schunck, Aurélia, additional, Sevin-Allouet, Mathieu, additional, Toulgoat, Frederique, additional, Wiertlewski, Sandrine, additional, Gauvrit, Jean-Yves, additional, Ronziere, Thomas, additional, Cahagne, Vincent, additional, Ferre, Jean-Christophe, additional, Pinel, Jean-François, additional, Raoult, Hélène, additional, Mas, Jean-Louis, additional, Meder, Jean-François, additional, Al Najjar-Carpentier, Amen-Adam, additional, Birchenall, Julia, additional, Bodiguel, Eric, additional, Calvet, David, additional, Domigo, Valérie, additional, Godon-Hardy, Sylvie, additional, Guiraud, Vincent, additional, Lamy, Catherine, additional, Majhadi, Loubna, additional, Morin, Ludovic, additional, Trystram, Denis, additional, Turc, Guillaume, additional, Berge, Jérôme, additional, Sibon, Igor, additional, Menegon, Patrice, additional, Barreau, Xavier, additional, Rouanet, François, additional, Debruxelles, Sabrina, additional, Kazadi, Annabelle, additional, Renou, Pauline, additional, Fleury, Olivier, additional, Pasco-Papon, Anne, additional, Dubas, Frédéric, additional, Caroff, Jildaz, additional, Godard Ducceschi, Sophie, additional, Hamon, Marie-Aurélie, additional, Lecluse, Alderic, additional, Marc, Guillaume, additional, Giroud, Maurice, additional, Ricolfi, Frédéric, additional, Bejot, Yannick, additional, Chavent, Adrien, additional, Gentil, Arnaud, additional, Kazemi, Apolline, additional, Osseby, Guy-Victor, additional, Voguet, Charlotte, additional, Mahagne, Marie-Hélène, additional, Sedat, Jacques, additional, Chau, Yves, additional, Suissa, Laurent, additional, Lachaud, Sylvain, additional, Houdart, Emmanuel, additional, Stapf, Christian, additional, Buffon Porcher, Frédérique, additional, Chabriat, Hugues, additional, Guedin, Pierre, additional, Herve, Dominique, additional, Jouvent, Eric, additional, Mawet, Jérôme, additional, Saint-Maurice, Jean-Pierre, additional, Schneble, Hans-Martin, additional, Nighoghossian, Norbert, additional, Berhoune, Nadia-Nawel, additional, Bouhour, Françoise, additional, Cho, Tae-Hee, additional, Derex, Laurent, additional, Felix, Sandra, additional, Gervais-Bernard, Hélène, additional, Gory, Benjamin, additional, Manera, Luis, additional, Mechtouff, Laura, additional, Ritzenthaler, Thomas, additional, Riva, Roberto, additional, Salaris Silvio, Fabrizio, additional, Tilikete, Caroline, additional, Blanc, Raphael, additional, Obadia, Michaël, additional, Bartolini, Mario Bruno, additional, Gueguen, Antoine, additional, Piotin, Michel, additional, Pistocchi, Silvia, additional, Redjem, Hocine, additional, Drouineau, Jacques, additional, Neau, Jean-Philippe, additional, Godeneche, Gaelle, additional, Lamy, Matthias, additional, Marsac, Emilia, additional, Velasco, Stephane, additional, Clavelou, Pierre, additional, Chabert, Emmanuel, additional, Bourgois, Nathalie, additional, Cornut-Chauvinc, Catherine, additional, Ferrier, Anna, additional, Gabrillargues, Jean, additional, Jean, Betty, additional, Marques, Anna-Raquel, additional, Vitello, Nicolas, additional, Detante, Olivier, additional, Barbieux, Marianne, additional, Boubagra, Kamel, additional, Favre Wiki, Isabelle, additional, Garambois, Katia, additional, Tahon, Florence, additional, Ashok, Vasdev, additional, Coskun, Oguzhan, additional, Rodesch, Georges, additional, Lapergue, Bertrand, additional, Bourdain, Frédéric, additional, Evrard, Serge, additional, Graveleau, Philippe, additional, Decroix, Jean Pierre, additional, Wang, Adrien, additional, Sellal, François, additional, Ahle, Guido, additional, Carelli, Gabriela, additional, Dugay, Marie-Hélène, additional, Gaultier, Claude, additional, Lebedinsky, Ariel Pablo, additional, Lita, Lavinia, additional, Musacchio, Raul Mariano, additional, Renglewicz-Destuynder, Catherine, additional, Tournade, Alain, additional, Vuillemet, Françis, additional, Montoro, Francisco Macian, additional, Mounayer, Charbel, additional, Faugeras, Frederic, additional, Gimenez, Laetitia, additional, Labach, Catherine, additional, Lautrette, Géraldine, additional, Denier, Christian, additional, Saliou, Guillaume, additional, Chassin, Olivier, additional, Dussaule, Claire, additional, Melki, Elsa, additional, Ozanne, Augustin, additional, Puccinelli, Francesco, additional, Sachet, Marina, additional, Sarov, Mariana, additional, Bonneville, Jean-François, additional, Moulin, Thierry, additional, Biondi, Alessandra, additional, De Bustos Medeiros, Elisabeth, additional, Vuillier, Fabrice, additional, Courtheoux, Patrick, additional, Viader, Fausto, additional, Apoil-Brissard, Marion, additional, Bataille, Mathieu, additional, Bonnet, Anne-Laure, additional, Cogez, Julien, additional, Touze, Emmanuel, additional, Leclerc, Xavier, additional, Leys, Didier, additional, Aggour, Mohamed, additional, Aguettaz, Pierre, additional, Bodenant, Marie, additional, Cordonnier, Charlotte, additional, Deplanque, Dominique, additional, Girot, Marie, additional, Henon, Hilde, additional, Kalsoum, Erwah, additional, Lucas, Christian, additional, Pruvo, Jean-Pierre, additional, Zuniga, Paolo, additional, Arquizan, Caroline, additional, Costalat, Vincent, additional, Machi, Paolo, additional, Mourand, Isabelle, additional, Riquelme, Carlos, additional, Bounolleau, Pierre, additional, Arteaga, Charles, additional, Faivre, Anthony, additional, Bintner, Marc, additional, Tournebize, Patrice, additional, Charlin, Cyril, additional, Darcel, Françoise, additional, Gauthier-Lasalarie, Pascale, additional, Jeremenko, Marcia, additional, Mouton, Servane, additional, Zerlauth, Jean-Baptiste, additional, Lamy, Chantal, additional, Hervé, Deramond, additional, Hassan, Hosseini, additional, Gaston, André, additional, Barral, Francis-Guy, additional, Garnier, Pierre, additional, Beaujeux, Rémy, additional, Wolff, Valérie, additional, Herbreteau, Denis, additional, Debiais, Séverine, additional, Murray, Alicia, additional, Ford, Gary, additional, Brown, Martin M, additional, Clifton, Andy, additional, Freeman, Janet, additional, Ford, Ian, additional, Markus, Hugh, additional, Wardlaw, Joanna, additional, Molyneux, Andy, additional, Robinson, Thompson, additional, Lewis, Steff, additional, Norrie, John, additional, Robertson, Fergus, additional, Perry, Richard, additional, Cloud, Geoffrey, additional, Clifton, Andrew, additional, Madigan, Jeremy, additional, Roffe, Christine, additional, Nayak, Sanjeev, additional, Lobotesis, Kyriakos, additional, Smith, Craig, additional, Herwadkar, Amit, additional, Kandasamy, Naga, additional, Goddard, Tony, additional, Bamford, John, additional, Subramanian, Ganesh, additional, Lenthall, Rob, additional, Littleton, Edward, additional, Lamin, Sal, additional, Storey, Kelley, additional, Ghatala, Rita, additional, Banaras, Azra, additional, Aeron-Thomas, John, additional, Hazel, Bath, additional, Maguire, Holly, additional, Veraque, Emelda, additional, Harrison, Louise, additional, Keshvara, Rekha, additional, and Cunningham, James, additional
Published: 2018
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17. The diversity of Klebsiella pneumoniae surface polysaccharides

Author: Follador, R, Heinz, E, Wyres, KL, Ellington, MJ, Kowarik, M, Holt, KE, Thomson, NR, Follador, R, Heinz, E, Wyres, KL, Ellington, MJ, Kowarik, M, Holt, KE, and Thomson, NR
Abstract: Klebsiella pneumoniae is considered an urgent health concern due to the emergence of multi-drug-resistant strains for which vaccination offers a potential remedy. Vaccines based on surface polysaccharides are highly promising but need to address the high diversity of surface-exposed polysaccharides, synthesized as O-antigens (lipopolysaccharide, LPS) and K-antigens (capsule polysaccharide, CPS), present in K. pneumoniae. We present a comprehensive and clinically relevant study of the diversity of O- and K-antigen biosynthesis gene clusters across a global collection of over 500 K. pneumoniae whole-genome sequences and the seroepidemiology of human isolates from different infection types. Our study defines the genetic diversity of O- and K-antigen biosynthesis cluster sequences across this collection, identifying sequences for known serotypes as well as identifying novel LPS and CPS gene clusters found in circulating contemporary isolates. Serotypes O1, O2 and O3 were most prevalent in our sample set, accounting for approximately 80 % of all infections. In contrast, K serotypes showed an order of magnitude higher diversity and differ among infection types. In addition we investigated a potential association of O or K serotypes with phylogenetic lineage, infection type and the presence of known virulence genes. K1 and K2 serotypes, which are associated with hypervirulent K. pneumoniae, were associated with a higher abundance of virulence genes and more diverse O serotypes compared to other common K serotypes.
Published: 2016

18. Definition of the bacterial N-glycosylation site consensus sequence.: EMBO J

Author: Kowarik, M., Young, N., Numao, S., Schulz, B., Hug, I., Callewaert, N., Mills, D., Watson, David, Kelly, J., Wacker, M., and Aebi, M.
Subjects: Consensus Sequence, SITE, bacterial, N-linked, SEQUENCE
Published: 2006

19. Immune cell subtyping in the cerebrospinal fluid of patients with neurological diseases

Author: Kowarik, M. C., primary, Grummel, V., additional, Wemlinger, S., additional, Buck, D., additional, Weber, M. S., additional, Berthele, A., additional, and Hemmer, B., additional
Published: 2013
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20. Severe multiple sclerosis relapse under fingolimod therapy: Incident or coincidence?

Author: Castrop, F., primary, Kowarik, M. C., additional, Albrecht, H., additional, Krause, M., additional, Haslinger, B., additional, Zimmer, C., additional, Berthele, A., additional, and Hemmer, B., additional
Published: 2012
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21. Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS

Author: Kowarik, M. C., primary, Pellkofer, H. L., additional, Cepok, S., additional, Korn, T., additional, Kumpfel, T., additional, Buck, D., additional, Hohlfeld, R., additional, Berthele, A., additional, and Hemmer, B., additional
Published: 2011
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22. Platelet-derived Growth Factor (PDGF) and PDGF Receptor Expression and Function in Folliculostellate Pituitary Cells

Author: Kowarik, M., primary, Onofri, C., additional, Colaco, T., additional, Stalla, G., additional, and Renner, U., additional
Published: 2009
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23. Truncated AcrA from Campylobacter jejuni for glycosylation studies

Author: Slynko, V., primary, Schubert, M., additional, Numao, S., additional, Kowarik, M., additional, Aebi, M., additional, and Allain, F., additional
Published: 2009
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24. Solution structure of an N-glycosylated protein using in vitro glycosylation

Author: Slynko, V., primary, Schubert, M., additional, Numao, S., additional, Kowarik, M., additional, Aebi, M., additional, and Allain, F.H.-T., additional
Published: 2009
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25. Octreotide inhibits PDGF-induced VEGF secretion in somatotroph MtT/S pituitary cells through interference at the PI3 kinase signalling pathway

Author: Colaco, T, primary, Onofri, C, additional, Theodoropoulou, M, additional, Kowarik, M, additional, Stalla, GK, additional, and Renner, U, additional
Published: 2007
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26. Integration of stimulatory and inhibitory signals in pituitary tumor cells through the PI3 kinase pathway

Author: Colaco, T, primary, Onofri, C, additional, Theodoropoulou, M, additional, Kowarik, M, additional, Stalla, GK, additional, and Renner, U, additional
Published: 2006
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27. Expression and function of platelet-derived growth factors (PDGF) and PDGF receptors in pituitary tumor cell lines

Author: Kowarik, M, primary, Onofri, C, additional, Theodoropoulou, M, additional, Stalla, GK, additional, and Renner, U, additional
Published: 2006
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28. Platelet-derived growth factor (PDGF) and PDGF receptor expression and function in pituitary tumor cell lines

Author: Kowarik, M, primary, Onofri, C, additional, Theodoropoulou, M, additional, Stalla, GK, additional, and Renner, U, additional
Published: 2005
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29. Structural insights from random mutagenesis of Campylobacter jejuni oligosaccharyltransferase PglB

Author: Ihssen Julian, Kowarik Michael, Wiesli Luzia, Reiss Renate, Wacker Michael, and Thöny-Meyer Linda
Subjects: glycosylation, oligosaccharyltransferase, PglB, Campylobacter jejuni, random mutagenesis, screening, ELISA, directed evolution, conjugate vaccine, Biotechnology, TP248.13-248.65
Abstract: Abstract Background Protein glycosylation is of fundamental importance in many biological systems. The discovery of N-glycosylation in bacteria and the functional expression of the N-oligosaccharyltransferase PglB of Campylobacter jejuni in Escherichia coli enabled the production of engineered glycoproteins and the study of the underlying molecular mechanisms. A particularly promising application for protein glycosylation in recombinant bacteria is the production of potent conjugate vaccines where polysaccharide antigens of pathogenic bacteria are covalently bound to immunogenic carrier proteins. Results In this study capsular polysaccharides of the clinically relevant pathogen Staphylococcus aureus serotype 5 (CP5) were expressed in Escherichia coli and linked in vivo to a detoxified version of Pseudomonas aeruginosa exotoxin (EPA). We investigated which amino acids of the periplasmic domain of PglB are crucial for the glycosylation reaction using a newly established 96-well screening system enabling the relative quantification of glycoproteins by enzyme-linked immunosorbent assay. A random mutant library was generated by error-prone PCR and screened for inactivating amino acid substitutions. In addition to 15 inactive variants with amino acid changes within the previously known, strictly conserved WWDYG motif of N-oligosaccharyltransferases, 8 inactivating mutations mapped to a flexible loop in close vicinity of the amide nitrogen atom of the acceptor asparagine as revealed in the crystal structure of the homologous enzyme C. lari PglB. The importance of the conserved loop residue H479 for glycosylation was confirmed by site directed mutagenesis, while a change to alanine of the adjacent, non-conserved L480 had no effect. In addition, we investigated functional requirements in the so-called MIV motif of bacterial N-oligosaccharyltransferases. Amino acid residues I571 and V575, which had been postulated to interact with the acceptor peptide, were subjected to cassette saturation mutagenesis. With the exception of I571C only hydrophobic residues were found in active variants. Variant I571V performed equally well as the wild type, cysteine at the same position reduced glycoprotein yield slightly, while a change to phenylalanine reduced activity by a factor of three. Conclusions This study provides novel structure-function relationships for the periplasmic domain of the Campylobacter jejuni N-oligosaccharyltransferase PglB and describes procedures for generating and screening oligosaccharyltransferase mutant libraries in an engineered E. coli system.
Published: 2012
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30. CXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammation

Author: Kowarik Markus C, Cepok Sabine, Sellner Johann, Grummel Verena, Weber Martin S, Korn Thomas, Berthele Achim, and Hemmer Bernhard
Subjects: CCL19, CCL21, CXCL12, CXCL13, BAFF, APRIL, B cells and plasmablasts, Neurology. Diseases of the nervous system, RC346-429
Abstract: Abstract Background The chemokines and cytokines CXCL13, CXCL12, CCL19, CCL21, BAFF and APRIL are believed to play a role in the recruitment of B cells to the central nervous system (CNS) compartment during neuroinflammation. To determine which chemokines/cytokines show the strongest association with a humoral immune response in the cerebrospinal fluid (CSF), we measured their concentrations in the CSF and correlated them with immune cell subsets and antibody levels. Methods Cytokine/chemokine concentrations were measured in CSF and serum by ELISA in patients with non-inflammatory neurological diseases (NIND, n = 20), clinically isolated syndrome (CIS, n = 30), multiple sclerosis (MS, n = 20), Lyme neuroborreliosis (LNB, n = 8) and patients with other inflammatory neurological diseases (OIND, n = 30). Albumin, IgG, IgA and IgM were measured by nephelometry. CSF immune cell subsets were determined by seven-color flow cytometry. Results CXCL13 was significantly elevated in the CSF of all patient groups with inflammatory diseases. BAFF levels were significantly increased in patients with LNB and OIND. CXCL12 was significantly elevated in patients with LNB. B cells and plasmablasts were significantly elevated in the CSF of all patients with inflammatory diseases. CXCL13 showed the most consistent correlation with CSF B cells, plasmablasts and intrathecal Ig synthesis. Conclusions CXCL13 seems to be the major determinant for B cell recruitment to the CNS compartment in different neuroinflammatory diseases. Thus, elevated CSF CXCL13 levels rather reflect a strong humoral immune response in the CNS compartment than being specific for a particular disease entity.
Published: 2012
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31. Reexpansion pulmonary edema following a posttraumatic pneumothorax: a case report and review of the literature

Author: Bechtold Barbara, Kowarik Markus C, Malota Mark, and Kopp Reinhard
Subjects: reexpansion pulmonary edema, acute pulmonary failure, posttraumatic pneumothorax, chest tube, Surgery, RD1-811, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract: Abstract The reexpansion pulmonary edema is a rare, but life threatening complication of a pneumothorax. Early recognition and a fast symptom orientated therapy are necessary for a good outcome. Several cases after non traumatic pneumothoraces are reported. We describe a patient who presented with a post-traumatic right pneumothorax. After the insertion of a chest tube he developed a reexpansion pulmonary edema, which had to be treated by an intubation. Additionally, a review of the literature regarding case reports of reexpansion pulmonary edema is presented.
Published: 2011
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32. Production of glycoprotein vaccines in Escherichia coli

Author: Ihssen Julian, Kowarik Michael, Dilettoso Sandro, Tanner Cyril, Wacker Michael, and Thöny-Meyer Linda
Subjects: Microbiology, QR1-502
Abstract: Abstract Background Conjugate vaccines in which polysaccharide antigens are covalently linked to carrier proteins belong to the most effective and safest vaccines against bacterial pathogens. State-of-the art production of conjugate vaccines using chemical methods is a laborious, multi-step process. In vivo enzymatic coupling using the general glycosylation pathway of Campylobacter jejuni in recombinant Escherichia coli has been suggested as a simpler method for producing conjugate vaccines. In this study we describe the in vivo biosynthesis of two novel conjugate vaccine candidates against Shigella dysenteriae type 1, an important bacterial pathogen causing severe gastro-intestinal disease states mainly in developing countries. Results Two different periplasmic carrier proteins, AcrA from C. jejuni and a toxoid form of Pseudomonas aeruginosa exotoxin were glycosylated with Shigella O antigens in E. coli. Starting from shake flask cultivation in standard complex medium a lab-scale fed-batch process was developed for glycoconjugate production. It was found that efficiency of glycosylation but not carrier protein expression was highly susceptible to the physiological state at induction. After induction glycoconjugates generally appeared later than unglycosylated carrier protein, suggesting that glycosylation was the rate-limiting step for synthesis of conjugate vaccines in E. coli. Glycoconjugate synthesis, in particular expression of oligosaccharyltransferase PglB, strongly inhibited growth of E. coli cells after induction, making it necessary to separate biomass growth and recombinant protein expression phases. With a simple pulse and linear feed strategy and the use of semi-defined glycerol medium, volumetric glycoconjugate yield was increased 30 to 50-fold. Conclusions The presented data demonstrate that glycosylated proteins can be produced in recombinant E. coli at a larger scale. The described methodologies constitute an important step towards cost-effective in vivo production of conjugate vaccines, which in future may be used for combating severe infectious diseases, particularly in developing countries.
Published: 2010
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33. The development and characterization of an E. coli O25B bioconjugate vaccine

Author: Gianluigi De Benedetto, Paola Cescutti, Micha A. Haeuptle, Kemmler Stefan J, Neil Ravenscroft, Michael J. Wacker, Michael Steffen, Dominique Sirena, Michael Kowarik, Matthias Zuppiger, Martin Braun, Michael Wetter, Kowarik, M., Wetter, M., Haeuptle, M. A., Braun, M., Steffen, M., Kemmler, S., Ravenscroft, N., De Benedetto, G., Zuppiger, M., Sirena, D., Cescutti, P., and Wacker, M.
Subjects: ST131, medicine.disease_cause, Biochemistry, Campylobacter jejuni, Microbiology, 03 medical and health sciences, Conjugate vaccine, medicine, Escherichia coli, Serotype O25B, Bioconjugate vaccine, Physicochemical characterization, Pseudomonas exotoxin, Molecular Biology, Pathogen, 030304 developmental biology, 0303 health sciences, Extraintestinal Pathogenic Escherichia coli, Vaccines, Conjugate, biology, Escherichia coli Vaccines, 030306 microbiology, Pseudomonas aeruginosa, Oligosaccharyltransferase, Cell Biology, biology.organism_classification, Original Article, Glycoconjugates
Abstract: Extraintestinal pathogenic Escherichia coli (ExPEC) cause a wide range of clinical diseases such as bacteremia and urinary tract infections. The increase of multidrug resistant ExPEC strains is becoming a major concern for the treatment of these infections and E. coli has been identified as a critical priority pathogen by the WHO. Therefore, the development of vaccines has become increasingly important, with the surface lipopolysaccharide constituting a promising vaccine target. This study presents genetic and structural analysis of clinical urine isolates from Switzerland belonging to the serotype O25. Approximately 75% of these isolates were shown to correspond to the substructure O25B only recently described in an emerging clone of E. coli sequence type 131. To address the high occurrence of O25B in clinical isolates, an O25B glycoconjugate vaccine was prepared using an E. coli glycosylation system. The O antigen cluster was integrated into the genome of E. coli W3110, thereby generating an E. coli strain able to synthesize the O25B polysaccharide on a carrier lipid. The polysaccharide was enzymatically conjugated to specific asparagine side chains of the carrier protein exotoxin A (EPA) of Pseudomonas aeruginosa by the PglB oligosaccharyltransferase from Campylobacter jejuni. Detailed characterization of the O25B-EPA conjugate by use of physicochemical methods including NMR and GC-MS confirmed the O25B polysaccharide structure in the conjugate, opening up the possibility to develop a multivalent E. coli conjugate vaccine containing O25B-EPA., Glycoconjugate Journal, 38 (4), ISSN:0282-0080, ISSN:1573-4986
Published: 2021

34. [The many different faces of MOGAD in the MRI: From FUEL to FLAMES].

Author: Horger M, Gohla G, Konrad EM, Baur D, Kowarik M, Farhang N, Ruff C, and Heckl S
Subjects: Humans, Magnetic Resonance Imaging methods, Central Nervous System Diseases diagnostic imaging
Abstract: Competing Interests: Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht.
Published: 2024
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35. Ultrafast Brain MRI at 3 T for MS: Evaluation of a 51-Second Deep Learning-Enhanced T2-EPI-FLAIR Sequence.

Author: Schuhholz M, Ruff C, Bürkle E, Feiweier T, Clifford B, Kowarik M, and Bender B
Abstract: In neuroimaging, there is no equivalent alternative to magnetic resonance imaging (MRI). However, image acquisitions are generally time-consuming, which may limit utilization in some cases, e.g., in patients who cannot remain motionless for long or suffer from claustrophobia, or in the event of extensive waiting times. For multiple sclerosis (MS) patients, MRI plays a major role in drug therapy decision-making. The purpose of this study was to evaluate whether an ultrafast, T2-weighted (T2w), deep learning-enhanced (DL), echo-planar-imaging-based (EPI) fluid-attenuated inversion recovery (FLAIR) sequence (FLAIR UF ) that has targeted neurological emergencies so far might even be an option to detect MS lesions of the brain compared to conventional FLAIR sequences. Therefore, 17 MS patients were enrolled prospectively in this exploratory study. Standard MRI protocols and ultrafast acquisitions were conducted at 3 tesla (T), including three-dimensional (3D)-FLAIR, turbo/fast spin-echo (TSE)-FLAIR, and FLAIR UF . Inflammatory lesions were grouped by size and location. Lesion conspicuity and image quality were rated on an ordinal five-point Likert scale, and lesion detection rates were calculated. Statistical analyses were performed to compare results. Altogether, 568 different lesions were found. Data indicated no significant differences in lesion detection (sensitivity and positive predictive value [PPV]) between FLAIR UF and axially reconstructed 3D-FLAIR (lesion size ≥3 mm × ≥2 mm) and no differences in sensitivity between FLAIR UF and TSE-FLAIR (lesion size ≥3 mm total). Lesion conspicuity in FLAIR UF was similar in all brain regions except for superior conspicuity in the occipital lobe and inferior conspicuity in the central brain regions. Further findings include location-dependent limitations of signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) as well as artifacts such as spatial distortions in FLAIR UF . In conclusion, FLAIR UF could potentially be an expedient alternative to conventional methods for brain imaging in MS patients since the acquisition can be performed in a fraction of time while maintaining good image quality.
Published: 2024
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36. Early REperfusion therapy with intravenous alteplase for recovery of VISION in acute central retinal artery occlusion (REVISION): Study protocol of a phase III trial.

Author: Poli S, Grohmann C, Wenzel DA, Poli K, Tünnerhoff J, Nedelmann M, Fiehler J, Burghaus I, Lehmann M, Glauch M, Schadwinkel HM, Kalmbach P, Zeller J, Peters T, Eschenfelder C, Agostini H, Campbell BC, Fischer MD, Sykora M, Mac Grory B, Feltgen N, Kowarik M, Seiffge D, Strbian D, Albrecht M, Alzureiqi MS, Auffarth G, Bäzner H, Behnke S, Berberich A, Bode F, Bohmann FO, Cheng B, Czihal M, Danyel LA, Dimopoulos S, Pinhal Ferreira de Pinho JD, Fries FN, Gamulescu MA, Gekeler F, Gomez-Exposito A, Gumbinger C, Guthoff R, Hattenbach LO, Kellert L, Khoramnia R, Kohnen T, Kürten D, Lackner B, Laible M, Lee JI, Leithner C, Liegl R, Lochner P, Mackert M, Mbroh J, Müller S, Nagel S, Prasuhn M, Purrucker J, Reich A, Mundiyanapurath S, Royl G, Salchow DJ, Schäfer JH, Schlachetzki F, Schmack I, Thomalla G, Tieck Fernandez MP, Wakili P, Walter P, Wolf A, Wolf M, Bartz-Schmidt KU, Schultheiss M, and Spitzer MS
Subjects: Humans, Double-Blind Method, Reperfusion methods, Treatment Outcome, Administration, Intravenous, Visual Acuity drug effects, Visual Acuity physiology, Male, Clinical Trials, Phase III as Topic, Female, Thrombolytic Therapy methods, Middle Aged, Retinal Artery Occlusion drug therapy, Tissue Plasminogen Activator therapeutic use, Tissue Plasminogen Activator administration & dosage, Fibrinolytic Agents therapeutic use, Fibrinolytic Agents administration & dosage, Recovery of Function drug effects
Abstract: Rationale: Meta-analyses of case series of non-arteritic central retinal artery occlusion (CRAO) indicate beneficial effects of intravenous thrombolysis when initiated early after symptom onset. Randomized data are lacking to address this question., Aims: The REperfusion therapy with intravenous alteplase for recovery of VISION in acute central retinal artery occlusion (REVISION) investigates intravenous alteplase within 4.5 h of monocular vision loss due to acute CRAO., Methods: This study is the randomized (1:1), double-blind, placebo-controlled, multicenter adaptive phase III trial., Study Outcomes: Primary outcome is functional recovery to normal or mildly impaired vision in the affected eye defined as best-corrected visual acuity of the Logarithm of the Minimum Angle of Resolution of 0.5 or less at 30 days (intention-to-treat analysis). Secondary efficacy outcomes include modified Rankin Score at 90 days and quality of life. Safety outcomes include symptomatic intracranial hemorrhage, major bleeding (International Society on Thrombosis and Haemostasis definition) and mortality. Exploratory analyses of optical coherence tomography/angiography, ultrasound and magnetic resonance imaging (MRI) biomarkers will be conducted., Sample Size: Using an adaptive design with interim analysis at 120 patients, up to 422 participants (211 per arm) would be needed for 80% power (one-sided alpha = 0.025) to detect a difference of 15%, assuming functional recovery rates of 10% in the placebo arm and 25% in the alteplase arm., Discussion: By enrolling patients within 4.5 h of CRAO onset, REVISION uses insights from meta-analyses of CRAO case series and randomized thrombolysis trials in acute ischemic stroke. Increased rates of early reperfusion and good neurological outcomes in stroke may translate to CRAO with its similar pathophysiology., Trial Registration: ClinicalTrials.gov: NCT04965038; EU Trial Number: 2023-507388-21-00., Competing Interests: Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Alteplase/placebo is provided by Boehringer Ingelheim at no costs. Boehringer Ingelheim was given opportunity to review the manuscript for medical/scientific accuracy and intellectual property considerations. The authors did not receive any payment related to trial/manuscript development.
Published: 2024
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37. Machine learning algorithms predict canine structural epilepsy with high accuracy.

Author: Flegel T, Neumann A, Holst AL, Kretzschmann O, Loderstedt S, Tästensen C, Gutmann S, Dietzel J, Becker LF, Kalliwoda T, Weiß V, Kowarik M, Böttcher IC, and Martin C
Abstract: Introduction: Clinical reasoning in veterinary medicine is often based on clinicians' personal experience in combination with information derived from publications describing cohorts of patients. Studies on the use of scientific methods for patient individual decision making are largely lacking. This applies to the prediction of the individual underlying pathology in seizuring dogs as well. The aim of this study was to apply machine learning to the prediction of the risk of structural epilepsy in dogs with seizures., Materials and Methods: Dogs with a history of seizures were retrospectively as well as prospectively included. Data about clinical history, neurological examination, diagnostic tests performed as well as the final diagnosis were collected. For data analysis, the Bayesian Network and Random Forest algorithms were used. A total of 33 features for Random Forest and 17 for Bayesian Network were available for analysis. The following four feature selection methods were applied to select features for further analysis: Permutation Importance, Forward Selection, Random Selection and Expert Opinion. The two algorithms Bayesian Network and Random Forest were trained to predict structural epilepsy using the selected features., Results: A total of 328 dogs of 119 different breeds were identified retrospectively between January 2017 and June 2021, of which 33.2% were diagnosed with structural epilepsy. An overall of 89,848 models were trained. The Bayesian Network in combination with the Random feature selection performed best. It was able to predict structural epilepsy with an accuracy of 0.969 (sensitivity: 0.857, specificity: 1.000) among all dogs with seizures using the following features: age at first seizure, cluster seizures, seizure in last 24 h, seizure in last 6 month, and seizure in last year., Conclusion: Machine learning algorithms such as Bayesian Networks and Random Forests identify dogs with structural epilepsy with a high sensitivity and specificity. This information could provide some guidance to clinicians and pet owners in their clinical decision-making process., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Flegel, Neumann, Holst, Kretzschmann, Loderstedt, Tästensen, Gutmann, Dietzel, Becker, Kalliwoda, Weiß, Kowarik, Böttcher and Martin.)
Published: 2024
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38. Penumbral Rescue by normobaric O = O administration in patients with ischemic stroke and target mismatch proFile (PROOF): Study protocol of a phase IIb trial.

Author: Poli S, Mbroh J, Baron JC, Singhal AB, Strbian D, Molina C, Lemmens R, Turc G, Mikulik R, Michel P, Tatlisumak T, Audebert HJ, Dichgans M, Veltkamp R, Hüsing J, Graessner H, Fiehler J, Montaner J, Adeyemi AK, Althaus K, Arenillas JF, Bender B, Benedikt F, Broocks G, Burghaus I, Cardona P, Deb-Chatterji M, Cviková M, Defreyne L, De Herdt V, Detante O, Ernemann U, Flottmann F, García Guillamón L, Glauch M, Gomez-Exposito A, Gory B, Sylvie Grand S, Haršány M, Hauser TK, Heck O, Hemelsoet D, Hennersdorf F, Hoppe J, Kalmbach P, Kellert L, Köhrmann M, Kowarik M, Lara-Rodríguez B, Legris L, Lindig T, Luntz S, Lusk J, Mac Grory B, Manger A, Martinez-Majander N, Mengel A, Meyne J, Müller S, Mundiyanapurath S, Naggara O, Nedeltchev K, Nguyen TN, Nilsson MA, Obadia M, Poli K, Purrucker JC, Räty S, Richard S, Richter H, Schilte C, Schlemm E, Stöhr L, Stolte B, Sykora M, Thomalla G, Tomppo L, van Horn N, Zeller J, Ziemann U, Zuern CS, Härtig F, and Tuennerhoff J
Subjects: Humans, Multicenter Studies as Topic, Oxygen therapeutic use, Quality of Life, Thrombectomy methods, Treatment Outcome, Clinical Trials, Phase II as Topic, Brain Ischemia complications, Endovascular Procedures methods, Ischemic Stroke complications, Ischemic Stroke diagnosis
Abstract: Rationale: Oxygen is essential for cellular energy metabolism. Neurons are particularly vulnerable to hypoxia. Increasing oxygen supply shortly after stroke onset could preserve the ischemic penumbra until revascularization occurs., Aims: PROOF investigates the use of normobaric oxygen (NBO) therapy within 6 h of symptom onset/notice for brain-protective bridging until endovascular revascularization of acute intracranial anterior-circulation occlusion., Methods and Design: Randomized (1:1), standard treatment-controlled, open-label, blinded endpoint, multicenter adaptive phase IIb trial., Study Outcomes: Primary outcome is ischemic core growth (mL) from baseline to 24 h (intention-to-treat analysis). Secondary efficacy outcomes include change in NIHSS from baseline to 24 h, mRS at 90 days, cognitive and emotional function, and quality of life. Safety outcomes include mortality, intracranial hemorrhage, and respiratory failure. Exploratory analyses of imaging and blood biomarkers will be conducted., Sample Size: Using an adaptive design with interim analysis at 80 patients per arm, up to 456 participants (228 per arm) would be needed for 80% power (one-sided alpha 0.05) to detect a mean reduction of ischemic core growth by 6.68 mL, assuming 21.4 mL standard deviation., Discussion: By enrolling endovascular thrombectomy candidates in an early time window, the trial replicates insights from preclinical studies in which NBO showed beneficial effects, namely early initiation of near 100% inspired oxygen during short temporary ischemia. Primary outcome assessment at 24 h on follow-up imaging reduces variability due to withdrawal of care and early clinical confounders such as delayed extubation and aspiration pneumonia., Trial Registrations: ClinicalTrials.gov: NCT03500939; EudraCT: 2017-001355-31., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Published: 2024
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39. Autologous haematopoietic stem cell transplantation for multiple sclerosis: a position paper and registry outline.

Author: Bayas A, Berthele A, Blank N, Dreger P, Faissner S, Friese MA, Gerdes LA, Grauer OM, Häussler V, Heesen C, Janson D, Korporal-Kuhnke M, Kowarik M, Kröger N, Lünemann JD, Martin R, Meier U, Meuth S, Muraro P, Platten M, Schirmer L, Stürner KH, Stellmann JP, Scheid C, Bergh FT, Warnke C, Wildemann B, and Ziemssen T
Abstract: Background: While substantial progress has been made in the development of disease-modifying medications for multiple sclerosis (MS), a high percentage of treated patients still show progression and persistent inflammatory activity. Autologous haematopoietic stem cell transplantation (AHSCT) aims at eliminating a pathogenic immune repertoire through intense short-term immunosuppression that enables subsequent regeneration of a new and healthy immune system to re-establish immune tolerance for a long period of time. A number of mostly open-label, uncontrolled studies conducted over the past 20 years collected about 4000 cases. They uniformly reported high efficacy of AHSCT in controlling MS inflammatory disease activity, more markedly beneficial in relapsing-remitting MS. Immunological studies provided evidence for qualitative immune resetting following AHSCT. These data and improved safety profiles of transplantation procedures spurred interest in using AHSCT as a treatment option for MS., Objective: To develop expert consensus recommendations on AHSCT in Germany and outline a registry study project., Methods: An open call among MS neurologists as well as among experts in stem cell transplantation in Germany started in December 2021 to join a series of virtual meetings., Results: We provide a consensus-based opinion paper authored by 25 experts on the up-to-date optimal use of AHSCT in managing MS based on the Swiss criteria. Current data indicate that patients who are most likely to benefit from AHSCT have relapsing-remitting MS and are young, ambulatory and have high disease activity. Treatment data with AHSCT will be collected within the German REgistry Cohort of autologous haematopoietic stem CeLl trAnsplantation In MS (RECLAIM)., Conclusion: Further clinical trials, including registry-based analyses, are urgently needed to better define the patient characteristics, efficacy and safety profile of AHSCT compared with other high-efficacy therapies and to optimally position it as a treatment option in different MS disease stages., Competing Interests: The authors declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article., (© The Author(s), 2023.)
Published: 2023
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40. Identification of a second glycoform of the clinically prevalent O1 antigen from Klebsiella pneumoniae .

Author: Kelly SD, Ovchinnikova OG, Müller F, Steffen M, Braun M, Sweeney RP, Kowarik M, Follador R, Lowary TL, Serventi F, and Whitfield C
Subjects: Animals, Lipopolysaccharides, O Antigens, Klebsiella, Blotting, Western, Klebsiella pneumoniae genetics, Klebsiella Infections prevention & control
Abstract: Carbapenemase and extended β-lactamase-producing Klebsiella pneumoniae isolates represent a major health threat, stimulating increasing interest in immunotherapeutic approaches for combating Klebsiella infections. Lipopolysaccharide O antigen polysaccharides offer viable targets for immunotherapeutic development, and several studies have described protection with O-specific antibodies in animal models of infection. O1 antigen is produced by almost half of clinical Klebsiella isolates. The O1 polysaccharide backbone structure is known, but monoclonal antibodies raised against the O1 antigen showed varying reactivity against different isolates that could not be explained by the known structure. Reinvestigation of the structure by NMR spectroscopy revealed the presence of the reported polysaccharide backbone (glycoform O1a), as well as a previously unknown O1b glycoform composed of the O1a backbone modified with a terminal pyruvate group. The activity of the responsible pyruvyltransferase (WbbZ) was confirmed by western immunoblotting and in vitro chemoenzymatic synthesis of the O1b terminus. Bioinformatic data indicate that almost all O1 isolates possess genes required to produce both glycoforms. We describe the presence of O1ab-biosynthesis genes in other bacterial species and report a functional O1 locus on a bacteriophage genome. Homologs of wbbZ are widespread in genetic loci for the assembly of unrelated glycostructures in bacteria and yeast. In K. pneumoniae , simultaneous production of both O1 glycoforms is enabled by the lack of specificity of the ABC transporter that exports the nascent glycan, and the data reported here provide mechanistic understanding of the capacity for evolution of antigenic diversity within an important class of biomolecules produced by many bacteria.
Published: 2023
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41. No evidence of oligoclonal bands, intrathecal immunoglobulin synthesis and B cell recruitment in acute ischemic stroke.

Author: Laichinger K, Bombach P, Dünschede J, Ruschil C, Stefanou MI, Dubois E, Poli S, Feil K, Ziemann U, Kowarik M, and Mengel A
Subjects: Humans, Oligoclonal Bands cerebrospinal fluid, Retrospective Studies, Immunoglobulin G, Ischemic Stroke complications, Central Nervous System Diseases, Multiple Sclerosis complications, Stroke complications
Abstract: Background: Within the past 10 years, immune mechanisms associated with acute ischemic stroke (AIS) have been brought into focus, but data on B cell activation and intrathecal Ig production is still scarce. In this study, we determined the prevalence of an elevated IgG index, positive oligoclonal bands (OCBs) and chemokine C-X-C motif ligand 13 (CXCL13) levels in the cerebrospinal fluid (CSF) as markers of intrathecal IgG synthesis and B cell activation in patients with AIS., Methods: In a retrospective study we analyzed the cerebrospinal fluid (CSF) from 212 patients with AIS from December 2013 to May 2018 assessing intrathecal Ig synthesis, OCBs and CXCL13 concentrations., Results: Overall, 5.7% (12/212) of AIS patients showed an intrathecal IgG synthesis, 0.5% (1/212) with isolated elevated IgG index, 5.2% (7/136) isolated positive OCBs and 2.9% (4/136) both elevated IgG index and positive OCBs. CXCL13 levels were elevated in 3.6% (3/83) of the patients. Approximately one third of these patients had simultaneously chronic inflammatory CNS disease (multiple sclerosis, neuromyelitis optica spectrum disorder, neurosarcoidosis). There was no significant association between CSF findings and stroke characteristics including vascular territory, localization, volume, etiology, acute treatment, or blood-brain barrier dysfunction. Intrathecal IgG synthesis was more common in patients with prior stroke. Longitudinal CSF analysis did not reveal any newly-occurring, but instead mostly persistent or even disappearing intrathecal IgG synthesis after AIS., Conclusions: We found no evidence of a relevant B cell recruitment and intrathecal IgG synthesis in patients with AIS. In fact, the occurrence of intrathecal IgG synthesis was associated with concurrent chronic inflammatory CNS disease or previous stroke. Consequently, in patients with first-ever AIS and intrathecal IgG synthesis, physicians should search for concomitant inflammatory CNS disease., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Laichinger et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Published: 2023
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42. Recurrent Acute Disseminated Encephalomyelitis (ADEM) after COVID-19-vaccination and after subsequent COVID-19-infection: A case report (part II).

Author: Poli K, Kowarik M, Hamprecht K, Iftner T, Ernemann U, Ziemann U, and Poli S
Abstract: Acute disseminated encephalomyelitis (ADEM) is an autoimmune disorder of the central nervous system (CNS), which is commonly associated to previous viral infection or immunization. Cases of ADEM with a potential relationship to both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination have been reported. We recently published a rare case of a 65-year-old patient who suffered from a corticosteroid- and immunoglobulin-refractory multiple autoimmune syndrome including ADEM following Pfizer-BioNTech coronavirus disease (COVID)-19 vaccination, and whose symptoms largely resolved after repeated plasma exchange (PE). Four months later, the patient was diagnosed with SARS-CoV-2 omicron variant infection after experiencing mild upper respiratory tract symptoms. Few days later, the patient developed severe tetraparesis with magnetic resonance imaging (MRI) showing multiple new inflammatory contrast-enhancing lesions in the left middle cerebellar peduncle, cervical spinal cord, and ventral conus medullaris. Repeated cerebrospinal fluid (CSF) analyses indicated blood-brain barrier damage (increased albumin ratio) without signs of SARS-CoV-2 invasion (mild pleocytosis, no intrathecal antibody production). SARS-CoV-2 specific immunoglobulin G (IgG) were detected in serum and to a much lower degree in CSF with close correlation between both concentrations over time, reflecting antibody dynamics of vaccine- and infection-induced immune response, and blood-brain barrier patency. Daily PE therapy was initiated. Given the patient's lack of improvement after seven PE, treatment with rituximab was considered. After a first dose, however, the patient suffered epididymo-orchitis leading to sepsis, and declined rituximab continuation. At 3-months follow-up, clinical symptoms had dramatically improved. The patient regained walking ability without assistance. This case of recurrent ADEM after COVID-19-vaccination and after subsequent COVID-19-infection strongly supports the hypotheses of neuroimmunological complications in these conditions being promoted by a systemic immune response and mediated by molecular mimicry of, both, viral and vaccine SARS-CoV-2 antigens and CNS self-antigens., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Poli, Kowarik, Hamprecht, Iftner, Ernemann, Ziemann and Poli.)
Published: 2023
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43. Structured Reporting in Multiple Sclerosis - Consensus-Based Reporting Templates for Magnetic Resonance Imaging of the Brain and Spinal Cord.

Author: Riederer I, Mühlau M, Wiestler B, Bender B, Hempel JM, Kowarik M, Huber T, Zimmer C, Andrisan T, Patzig M, Zimmermann H, Havla J, Berlis A, Behrens L, Beer M, Dietrich J, Sollmann N, and Kirschke JS
Subjects: Young Adult, Humans, Consensus, Brain diagnostic imaging, Magnetic Resonance Imaging methods, Spinal Cord diagnostic imaging, Multiple Sclerosis diagnostic imaging, Neurodegenerative Diseases
Abstract: As a result of technical developments and greater availability of imaging equipment, the number of neuroradiological examinations is steadily increasing [1]. Due to improved image quality and sensitivity, more details can be detected making reporting more complex and time-intensive. At the same time, reliable algorithms increasingly allow quantitative image analysis that should be integrated in reports in a standardized manner. Moreover, increasing digitalization is resulting in a decrease in the personal exchange between neuroradiologists and referring disciplines, thereby making communication more difficult. The introduction of structured reporting tailored to the specific disease and medical issue [2, 3] and corresponding to at least the second reporting level as defined by the German Radiological Society (https://www.befundung.drg.de/de-DE/2908/strukturierte-befundung/) is therefore desirable to ensure that the quality standards of neuroradiological reports continue to be met.The advantages of structured reporting include a reduced workload for neuroradiologists and an information gain for referring physicians. A complete and standardized list with relevant details for image reporting is provided to neuroradiologists in accordance with the current state of knowledge, thereby ensuring that important points are not forgotten [4]. A time savings and increase in efficiency during reporting were also seen [5]. Further advantages include report clarity and consistency and better comparability in follow-up examinations regardless of the neuroradiologist's particular reporting style. This results in better communication with the referring disciplines and makes clinical decision significantly easier [6, 7]. Although the advantages are significant, any potential disadvantages like the reduction of autonomy in reporting and inadequate coverage of all relevant details and any incidental findings not associated with the main pathology in complex cases or in rare diseases should be taken into consideration [4]. Therefore, studies examining the advantages of structured reporting, promoting the introduction of this system in the clinical routine, and increasing the acceptance among neuroradiologists are still needed.Numerous specific templates for structured reporting, e. g., regarding diseases in cardiology and oncology, are already available on the website www.befundung.drg.de . Multiple sclerosis (MS) is an idiopathic chronic inflammatory and neurodegenerative disease of the central nervous system and is the most common non-trauma-based inflammatory neurological disease in young adults. Therefore, it has significant individual and socioeconomic relevance [8]. Magnetic resonance imaging (MRI) plays an important role in the diagnosis, prognosis evaluation, and follow-up of this disease. MRI is established as the central diagnostic method in the diagnostic criteria. Therefore, specific changes are seen on MRI in almost all patients with a verified MS diagnosis [9]. Reporting of MRI datasets regarding the brain and spinal cord of patients with MS includes examination of the images with respect to the relevant medical issue in order to determine whether the McDonald criteria, which were revised in 2017 [10] and define dissemination in time and space clinically as well as with respect to MRI based on the recommendations of the MAGNIMS groups [11, 12], are fulfilled. A more precise definition of lesion types and locations according to the recommendations of an international expert group [13] is discussed in the supplementary material. Spinal cord signal abnormalities are seen in up to 92 % of MS patients [14-16] and are primarily located in the cervical spine [15]. The recommendations of the MAGNIMS-CMSC-NAIMS working group published in 2021 [11] explicitly recommend the use of structured reporting for MS patients.Therefore, a reporting template for evaluating MRI examinations of the brain and spinal cord of patients with MS was created as part of the BMBF-funded DIFUTURE consortium in consensus with neuroradiological and neurological experts in concordance with the recommendations mentioned above [11] and was made available for broad use (https://github.com/DRGagit/ak_befundung). The goal is to facilitate efficient and comprehensive evaluation of patients with MS in the primary diagnostic workup and follow-up imaging. These reporting templates are consensus-based recommendations and do not make any claim to general validity or completeness. The information technology working group (@GIT) of the German Radiological Society and the German Society for Neuroradiology strive to keep the reporting templates presented here up-to-date with respect to new research data and recommendations of the MAGNIMS-CMSC-NAIMS group [11]. KEY POINTS:: · consensus-based reporting templates. · template for the structured reporting of MRI examinations of patients with multiple sclerosis. · structured reporting might facilitate communication between neuroradiologists and referring disciplines. CITATION FORMAT: · Riederer I, Mühlau M, Wiestler B et al. Structured Reporting in Multiple Sclerosis - Consensus-Based Reporting Templates for Magnetic Resonance Imaging of the Brain and Spinal Cord. Fortschr Röntgenstr 2023; 195: 135 - 138., Competing Interests: JH reports grants for OCT research from the Friedrich-Baur-Stiftung and Merck, personal fees and non-financial support from Celgene, Merck, Alexion, Novartis, Roche, Santhera, Biogen, Heidelberg Engineering, Sanofi Genzyme and non-financial support of the Guthy-Jackson Charitable Foundation, all outside the submitted work.Thomas Huber ist neben seiner im Manuskript genannten Affiliation bei der Firma Smart Reporting GmbH beschäftigt.Jan Kirschke ist neben seiner im Manuskript genannten Affiliation Co-Founder der Firma BoneScreen GmbH., (Thieme. All rights reserved.)
Published: 2023
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44. The development and characterization of an E. coli O25B bioconjugate vaccine.

Author: Kowarik M, Wetter M, Haeuptle MA, Braun M, Steffen M, Kemmler S, Ravenscroft N, De Benedetto G, Zuppiger M, Sirena D, Cescutti P, and Wacker M
Subjects: Vaccines, Conjugate, Escherichia coli classification, Escherichia coli Vaccines immunology, Glycoconjugates
Abstract: Extraintestinal pathogenic Escherichia coli (ExPEC) cause a wide range of clinical diseases such as bacteremia and urinary tract infections. The increase of multidrug resistant ExPEC strains is becoming a major concern for the treatment of these infections and E. coli has been identified as a critical priority pathogen by the WHO. Therefore, the development of vaccines has become increasingly important, with the surface lipopolysaccharide constituting a promising vaccine target. This study presents genetic and structural analysis of clinical urine isolates from Switzerland belonging to the serotype O25. Approximately 75% of these isolates were shown to correspond to the substructure O25B only recently described in an emerging clone of E. coli sequence type 131. To address the high occurrence of O25B in clinical isolates, an O25B glycoconjugate vaccine was prepared using an E. coli glycosylation system. The O antigen cluster was integrated into the genome of E. coli W3110, thereby generating an E. coli strain able to synthesize the O25B polysaccharide on a carrier lipid. The polysaccharide was enzymatically conjugated to specific asparagine side chains of the carrier protein exotoxin A (EPA) of Pseudomonas aeruginosa by the PglB oligosaccharyltransferase from Campylobacter jejuni. Detailed characterization of the O25B-EPA conjugate by use of physicochemical methods including NMR and GC-MS confirmed the O25B polysaccharide structure in the conjugate, opening up the possibility to develop a multivalent E. coli conjugate vaccine containing O25B-EPA.
Published: 2021
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45. Posterior reversible encephalopathy syndrome in a melanoma patient with dabrafenib and trametinib treatment following immunotherapy.

Author: Stefanou MI, Gepfner-Tuma I, Brendle C, Kowarik M, Meiwes A, Eigentler T, Müller A, Garbe C, Ziemann U, Tabatabai G, and Forschner A
Subjects: Adult, Antineoplastic Combined Chemotherapy Protocols adverse effects, Female, Humans, Immunotherapy adverse effects, Ipilimumab adverse effects, Nivolumab adverse effects, Imidazoles adverse effects, Melanoma drug therapy, Oximes adverse effects, Posterior Leukoencephalopathy Syndrome etiology, Pyridones adverse effects, Pyrimidinones adverse effects, Skin Neoplasms drug therapy
Published: 2020
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46. Posteriores reversibles Enzephalopathie-Syndrom bei einem Melanompatienten unter Dabrafenib- und Trametinib-Behandlung nach Immuntherapie.

Author: Stefanou MI, Gepfner-Tuma I, Brendle C, Kowarik M, Meiwes A, Eigentler T, Müller A, Garbe C, Ziemann U, Tabatabai G, and Forschner A
Published: 2020
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47. Characterization and immunogenicity of a Shigella flexneri 2a O-antigen bioconjugate vaccine candidate.

Author: Ravenscroft N, Braun M, Schneider J, Dreyer AM, Wetter M, Haeuptle MA, Kemmler S, Steffen M, Sirena D, Herwig S, Carranza P, Jones C, Pollard AJ, Wacker M, and Kowarik M
Subjects: Animals, Female, O Antigens chemistry, Rats, Rats, Sprague-Dawley, Shigella flexneri chemistry, Shigella flexneri growth & development, Vaccines, Conjugate chemistry, Immunogenicity, Vaccine immunology, O Antigens immunology, Shigella flexneri immunology, Vaccines, Conjugate immunology
Abstract: Shigellosis remains a major cause of diarrheal disease in developing countries and causes substantial morbidity and mortality in children. Vaccination represents a promising preventive measure to fight the burden of the disease, but despite enormous efforts, an efficacious vaccine is not available to date. The use of an innovative biosynthetic Escherichia coli glycosylation system substantially simplifies the production of a multivalent conjugate vaccine to prevent shigellosis. This bioconjugation approach has been used to produce the Shigella dysenteriae type O1 conjugate that has been successfully tested in a phase I clinical study in humans. In this report, we describe a similar approach for the production of an additional serotype required for a broadly protective shigellosis vaccine candidate. The Shigella flexneri 2a O-polysaccharide is conjugated to introduced asparagine residues of the carrier protein exotoxin A (EPA) from Pseudomonas aeruginosa by co-expression with the PglB oligosaccharyltransferase. The bioconjugate was purified, characterized using physicochemical methods and subjected to preclinical evaluation in rats. The bioconjugate elicited functional antibodies as shown by a bactericidal assay for S. flexneri 2a. This study confirms the applicability of bioconjugation for the S. flexneri 2a O-antigen, which provides an intrinsic advantage over chemical conjugates due to the simplicity of a single production step and ease of characterization of the homogenous monomeric conjugate formed. In addition, it shows that bioconjugates are able to raise functional antibodies against the polysaccharide antigen., (© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Published: 2019
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48. The diversity of Klebsiella pneumoniae surface polysaccharides.

Author: Follador R, Heinz E, Wyres KL, Ellington MJ, Kowarik M, Holt KE, and Thomson NR
Subjects: Antigens, Bacterial genetics, Antigens, Surface genetics, Humans, Klebsiella pneumoniae classification, O Antigens genetics, Phylogeny, Seroepidemiologic Studies, Serogroup, Genetic Variation, Klebsiella pneumoniae genetics, Klebsiella pneumoniae pathogenicity, Virulence genetics
Abstract: Klebsiella pneumoniae is considered an urgent health concern due to the emergence of multi-drug-resistant strains for which vaccination offers a potential remedy. Vaccines based on surface polysaccharides are highly promising but need to address the high diversity of surface-exposed polysaccharides, synthesized as O-antigens (lipopolysaccharide, LPS) and K-antigens (capsule polysaccharide, CPS), present in K. pneumoniae . We present a comprehensive and clinically relevant study of the diversity of O- and K-antigen biosynthesis gene clusters across a global collection of over 500 K. pneumoniae whole-genome sequences and the seroepidemiology of human isolates from different infection types. Our study defines the genetic diversity of O- and K-antigen biosynthesis cluster sequences across this collection, identifying sequences for known serotypes as well as identifying novel LPS and CPS gene clusters found in circulating contemporary isolates. Serotypes O1, O2 and O3 were most prevalent in our sample set, accounting for approximately 80 % of all infections. In contrast, K serotypes showed an order of magnitude higher diversity and differ among infection types. In addition we investigated a potential association of O or K serotypes with phylogenetic lineage, infection type and the presence of known virulence genes. K1 and K2 serotypes, which are associated with hypervirulent K. pneumoniae , were associated with a higher abundance of virulence genes and more diverse O serotypes compared to other common K serotypes.
Published: 2016
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49. An antibacterial vaccination strategy based on a glycoconjugate containing the core lipopolysaccharide tetrasaccharide Hep2Kdo2.

Author: Kong L, Vijayakrishnan B, Kowarik M, Park J, Zakharova AN, Neiwert L, Faridmoayer A, and Davis BG
Subjects: Diphtheria Toxin chemistry, Glycoconjugates metabolism, Lipopolysaccharides metabolism, Neisseria meningitidis drug effects, Neisseria meningitidis metabolism, Pseudomonas aeruginosa drug effects, Pseudomonas aeruginosa metabolism, Bacterial Vaccines chemistry, Bacterial Vaccines metabolism, Bacterial Vaccines pharmacology, Glycoconjugates chemistry, Lipopolysaccharides chemistry, Microbial Viability drug effects
Abstract: Certain non-mammalian cell wall sugars are conserved across a variety of pathogenic bacteria. This conservation of structure, combined with their structural differences when compared with mammalian sugars, make them potentially powerful epitopes for immunization. Here, we report the synthesis of a glycoconjugate that displays the so-called 'inner core' sugars of Gram-negative bacterial cell walls. We also describe an antibacterial vaccination strategy based on immunization with the glycoconjugate and the subsequent administration of an inhibitor that uncovers the corresponding epitope in pathogenic bacteria. The core tetrasaccharide, Hep2Kdo2, a common motif in bacterial lipopolysaccharides, was synthesized and attached via a chain linker to a diphtheria toxin mutant carrier protein. This glycoconjugate generated titres of antibodies towards the inner core tetrasaccharide of the lipopolysaccharide, which were capable of binding the cell-surface sugars of bacterial pathogenic strains including Neisseria meningitidis, Pseudomonas aeruginosa and Escherichia coli. Exposure of bacterial lipopolysaccharide in in vitro experiments, using an inhibitor of capsular polysaccharide transport, enabled potent bacterial killing with antiserum.
Published: 2016
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50. Purification and characterization of a Shigella conjugate vaccine, produced by glycoengineering Escherichia coli.

Author: Ravenscroft N, Haeuptle MA, Kowarik M, Fernandez FS, Carranza P, Brunner A, Steffen M, Wetter M, Keller S, Ruch C, and Wacker M
Subjects: Bacterial Proteins genetics, Bacterial Proteins metabolism, Endotoxins genetics, Endotoxins metabolism, Escherichia coli genetics, Escherichia coli metabolism, Glycoproteins genetics, Glycoproteins metabolism, Glycosylation, Glycosyltransferases genetics, Glycosyltransferases metabolism, Protozoan Proteins genetics, Protozoan Proteins metabolism, Pseudomonas aeruginosa enzymology, Vaccines, Conjugate immunology, Protein Processing, Post-Translational, Protozoan Vaccines immunology, Shigella dysenteriae immunology
Abstract: Shigellosis remains a major cause of diarrheal disease in developing countries and causes substantial morbidity and mortality in children. Glycoconjugate vaccines consisting of bacterial surface polysaccharides conjugated to carrier proteins are the most effective vaccines for controlling invasive bacterial infections. Nevertheless, the development of a multivalent conjugate vaccine to prevent Shigellosis has been hampered by the complex manufacturing process as the surface polysaccharide for each strain requires extraction, hydrolysis, chemical activation and conjugation to a carrier protein. The use of an innovative biosynthetic Escherichia coli glycosylation system substantially simplifies the production of glycoconjugates. Herein, the Shigella dysenteriae type 1 (Sd1) O-polysaccharide is expressed and its functional assembly on an E. coli glycosyl carrier lipid is demonstrated by HPLC analysis and mass spectrometry. The polysaccharide is enzymatically conjugated to specific asparagine residues of the carrier protein by co-expression of the PglB oligosaccharyltransferase and the carrier protein exotoxin A (EPA) from Pseudomonas aeruginosa. The extraction and purification of the Shigella glycoconjugate (Sd1-EPA) and its detailed characterization by the use of physicochemical methods including NMR and mass spectrometry is described. The report shows for the first time that bioconjugation provides a newly developed and improved approach to produce an Sd1 glycoconjugate that can be characterized using state-of-the-art techniques. In addition, this generic process together with the analytical methods is ideally suited for the production of additional Shigella serotypes, allowing the development of a multivalent Shigella vaccine., (© The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Published: 2016
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