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2. Patient-reported outcomes before treatment for localized prostate cancer: are there differences among countries? Data from the True North Global Registry.

Author

Garin, O, Kowalski, C, Zamora, V, Roth, R, Ferrer, M, Breidenbach, C, Pont, A, Belin, T, Elashoff, D, Wilhalme, H, Nguyen, A, Kwan, L, Pearman, E, Bolagani, A, Sampurno, F, Papa, N, Moore, C, Millar, J, Connor, S, Villanti, P, and Litwin, M

Subjects
Health-related quality of life, Patient-reported outcomes, Prostate cancer, Registry, Humans, Male, Brachytherapy, Patient Reported Outcome Measures, Prospective Studies, Prostatectomy, Prostatic Neoplasms, Quality of Life, Registries, Urinary Incontinence, Multicenter Studies as Topic
Abstract

INTRODUCTION: Similar Patient-Reported Outcomes (PROs) at diagnosis for localized prostate cancer among countries may indicate that different treatments are recommended to the same profile of patients, regardless the context characteristics (health systems, medical schools, culture, preferences…). The aim of this study was to assess such comparison. METHODS: We analyzed the EPIC-26 results before the primary treatment of men diagnosed of localized prostate cancer from January 2017 onwards (revised data available up to September 2019), from a multicenter prospective international cohort including seven regions: Australia/New Zealand, Canada, Central Europe (Austria / Czech Republic / Germany), United Kingdom, Italy, Spain, and the United States. The EPIC-26 domain scores and pattern of three selected items were compared across regions (with Central Europe as reference). All comparisons were made stratifying by treatment: radical prostatectomy, external radiotherapy, brachytherapy, and active surveillance. RESULTS: The sample included a total of 13,483 men with clinically localized or locally advanced prostate cancer. PROs showed different domain patterns before treatment across countries. The sexual domain was the most impaired, and the one with the highest dispersion within countries and with the greatest medians differences across countries. The urinary incontinence domain, together with the bowel and hormonal domains, presented the highest scores (better outcomes) for all treatment groups, and homogeneity across regions. CONCLUSIONS: Patients with localized or locally advanced prostate cancer undergoing radical prostatectomy, EBRT, brachytherapy, or active surveillance presented mainly negligible or small differences in the EPIC-26 domains before treatment across countries. The results on urinary incontinence or bowel domains, in which almost all patients presented the best possible score, may downplay the baseline data role for evaluating treatments effects. However, the heterogeneity within countries and the magnitude of the differences found across countries in other domains, especially sexual, support the need of implementing the PRO measurement from diagnosis.

Published
2023

33. Evaluation einer transsektoralen digitalen Versorgungsplattform für Personen mit familiärem Krebsrisiko - dVP_FAM: ein Studienprotokoll

Author

Klein, K, Speiser, D, Thomas, P, Schüürhuis, S, Kowalski, C, Felbor, U, Amirpour-Mehrhof, N, Lotz, B, Stegen, S, Reinhold, T, Schmid, C, Mangum, T, Jungnickel, K, Feufel, MA, Kendel, F, Klein, K, Speiser, D, Thomas, P, Schüürhuis, S, Kowalski, C, Felbor, U, Amirpour-Mehrhof, N, Lotz, B, Stegen, S, Reinhold, T, Schmid, C, Mangum, T, Jungnickel, K, Feufel, MA, and Kendel, F

Published
2023

34. Ethics in ecological forecasting: Four case-based teaching modules

Author

Global Ecohydrology and Sustainability, Environmental Sciences, Lewis, A.S.L., Howard, D.W., Koren, Gerbrand, Kowalski, C., McLachlan, J., Peters, J.A., Smies, G., Tabares, O., Global Ecohydrology and Sustainability, Environmental Sciences, Lewis, A.S.L., Howard, D.W., Koren, Gerbrand, Kowalski, C., McLachlan, J., Peters, J.A., Smies, G., and Tabares, O.

Published
2023

35. Grandiose narcissism indirectly associates with lower psychopathology across five countries

Author

Papageorgiou, K, Denovan, A, Dagnall, N, Hill-Artamonova, E, Gianniou, F, Papageorgiou, S, Plouffe, R, Kowalski, C, Saklofske, D, Kyriazos, T, Stalikas, A, Costantini, G, Papageorgiou, KA, Gianniou, FM, Plouffe, RA, Kowalski, CM, Saklofske, DH, Papageorgiou, K, Denovan, A, Dagnall, N, Hill-Artamonova, E, Gianniou, F, Papageorgiou, S, Plouffe, R, Kowalski, C, Saklofske, D, Kyriazos, T, Stalikas, A, Costantini, G, Papageorgiou, KA, Gianniou, FM, Plouffe, RA, Kowalski, CM, and Saklofske, DH

Abstract

Using five independent non-clinical cross-cultural samples (total N = 3649; overall Mage = 29.31; 31% male and 69% female), this study explored the extent to which Dark Triad traits were indirectly associated with symptoms of psychopathology through mental toughness. Although Machiavellianism and psychopathy have not been studied extensively in this context, previous research (both cross-sectional and longitudinal) reports that grandiose narcissism increases mental toughness contributing indirectly to positive outcomes such as lower anxiety, stress, and depression. Accordingly, this study examined Machiavellianism, psychopathy, and narcissism in the context of mental toughness and psychopathology. A particular focus was placed on investigating negative relationships between grandiose narcissism and psychopathology. Participants completed self-report measures assessing the Dark Triad, mental toughness, and psychopathology. In all samples, grandiose narcissism exerted moderate negative, indirect associations with anxiety, stress, and depression through mental toughness. Relationships between Machiavellianism and psychopathy and psychopathology were generally weak and positive but varied across countries. Findings provided further cross-cultural support for a mediation model in which grandiose narcissism is related to higher mental toughness and lower psychopathology. Outcomes from this study indicate that exploration of the link between grandiose narcissism and resilience traits such as mental toughness can provide important conceptual insights into the adaptive properties of narcissism, and help to explain why grandiose narcissism is associated with a decrease in some psychopathological symptoms.

Published
2023

37. Vergleich von linearer und Tobit-Regression zur Analyse von Patient-Reported-Outcomes

Author

Hagemeier, A, Kowalski, C, Breidenbach, C, Sibert, NT, Dieng, S, Wesselmann, S, and Roth, R

Subjects
ddc: 610, Medicine and health
Abstract

Hintergrund und Stand (inter)nationaler Forschung: Fragebogen-basierte Daten wie Patient-Reported Outcomes (PROs) sind auf einen vorab definierten Wertebereich eingegrenzt und können Boden- und Deckeneffekte aufweisen. Dennoch werden zur Analyse entsprechender Zielparameter meist lineare Regressionen [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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48. Current clinical practice and outcome of neoadjuvant chemotherapy for early breast cancer: analysis of individual data from 94,638 patients treated in 55 breast cancer centers

Author

Ortmann, Olaf, Blohmer, J.-U., Sibert, N. T., Brucker, S., Janni, W., Wöckel, A., Scharl, A., Dieng, S., Ferencz, J., Inwald, E. C., Wesselmann, S., Kowalski, C., Denisjuk, E., Csorba, R., Rezek, D., Peschel, S., Denschlag, D., Schad, F., Dieterle, D., Lex, B., Rieger, L., Flock, F., Cramer, A., Strittmatter, H.-J., Bettscheider, J., Lindner, C., Stefek, A., Pauker, W., Hönig, A., Schrauder, M., Seeger, D., Kleine-Tebbe, A., Bleimehl, A., Groh, U., Gebauer, G., Vollert, H.-W., Zorr, A., Friedmann, W., Krabisch, P., Fritz, S., Schwämmle, A., Lucke, W., Schmatloch, S., Heyl, W., Deuschle, P., Arfsten, M., Scheler, P., Ruf-Dördelmann, A., Brückner, B., Bauer, L., Koch, M., Monner, J., Nixdorf, A., Merte, A., Beldermann, F., Felberbaum, R., De Wilde, R. L., Bolkenius, P., Lebrecht, A., Solomayer, E.-F., Hartmann, S., and Hartkopf, A.

Subjects
ddc:610, Early breast cancer · Neoadjuvant chemotherapy · Breast cancer centers · Guidelines · Oncobox research, 610 Medizin, skin and connective tissue diseases
Abstract

Neoadjuvant chemotherapy (NACT) is frequently used in patients with early breast cancer. Randomized controlled trials have demonstrated similar survival after NACT or adjuvant chemotherapy (ACT). However, certain subtypes may benefit more when NACT contains regimes leading to high rates of pathologic complete response (pCR) rates. In this study we analyzed data using the OncoBox research from 94,638 patients treated in 55 breast cancer centers to describe the current clinical practice of and outcomes after NACT under routine conditions. These data were compared to patients treated with ACT. 40% of all patients received chemotherapy. The use of NACT increased over time from 5% in 2007 up to 17.3% in 2016. The proportion of patients receiving NACT varied by subtype. It was low in patients with HR-positive/HER2-negative breast cancer (5.8%). However, 31.8% of patients with triple-negative, 31.9% with HR-negative/HER2-positive, and 26.5% with HR-positive/HER2-positive breast cancer received NACT. The rates of pCR were higher in patients with HR-positive/HER2-positive, HR negative/HER2-positive and triple-negative tumors (36, 53 and 38%) compared to HR-positive/HER2-negative tumors (12%). PCR was achieved more often in HER2-positive and triple-negative tumors over time. This is the largest study on use and effects of NACT in German breast cancer centers. It demonstrates the increased use of NACT based on recommendations in current clinical guidelines. An improvement of pCR was shown in particular in HER2-positive and triple-negative breast cancer, which is consistent with data from randomized controlled trails.

Published
2022

49. Treatment of Japanese knotweed-infested soils by thermal desorption

Author

Meerbeek, K. van, Amodio, N., Kowalski, C., Melis, J., Winckel, S. van, Beek, E. van, Meerbeek, K. van, Amodio, N., Kowalski, C., Melis, J., Winckel, S. van, and Beek, E. van

Abstract

Japanese knotweed (Fallopia japonica) is an alien plant species in Europe and North America, which means that it is not native to these continents. It originates from East Asia and was introduced as an ornamental and forage plant to Europe and North America in the 19th century. After its introduction, it successfully established and spread itself, thereby outcompeting native species. In addition to harming biodiversity, it can damage human infrastructures such as roads, buildings and river dikes. It is currently listed by the International Union for Conservation of Nature (IUCN) as one of the 100 worst invasive alien species worldwide. Due to the many problems caused by Japanese knotweed, effective management is of great importance. Yet, because the plant species has an extensive and robust rhizome network, the plant is very resistant to management actions targeting the aboveground part of the plant, which makes eradication difficult. In addition, as the plant spreads vegetatively through rhizome and stem fragments, any cutting or mowing action inherently carries the risk of creating new spreading events. Here, we investigate the feasibility of the Smart Burners™ technology, patented by HAEMERS Technologies, to eradicate Japanese knotweed. This technology is originally developed for thermal desorption, a soil remediation technique whereby contaminated soils are heated to physically separate the contaminants. In the management of Japanese knotweed, it targets the underground parts of the plant by heating affected soils. This document presents the results of a series of experiments to explore the potential of this new eradication method.

Published
2022

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