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439 results on '"Kowalska, T."'

7. Hydrophilic retention mechanism of imidazoline and serotonin receptor ligands in thin-layer and high-performance liquid chromatography systems

Author

Obradović, Darija, Obradović, Darija, Savić, Jelena, Joksimović, J., Kowalska, T., Agbaba, Danica, Obradović, Darija, Obradović, Darija, Savić, Jelena, Joksimović, J., Kowalska, T., and Agbaba, Danica

Abstract

We investigated and compared hydrophilic retention mechanism (HILIC) of ten compounds (imidazoline and serotonin receptor ligands) in the thin-layer chromatographic (TLC) system and the high-performance liquid chromatographic (HPLC) system. The TLC and HPLC stationary phases were the chemically bonded amino (NH2) phases. In the TLC mode, the binary mobile phases were composed of acetonitrile (as the main component) and water or methanol (as the modifier). In the HPLC mode, the binary mobile phase was composed of acetonitrile (as the main component) and methanol (as the modifier). For each compound, we determined this region for which linear relationship between the retention and volume fraction of the mobile phase modifier was observed, and the retention behaviour was described by the linear solvent strength (LSS) model. With the obtained regression constant values (log k0, RM0) in mind, we selected molecular parameters influencing retention mechanism in the considered chromatographic systems. Lipophilicity plays an important role in the TLC mode with the acetonitrile‒methanol mobile phase, while geometrical characteristics of the test compounds (ring complexity, number of multiple bonds) play a predominant role in the TLC mode with the acetonitrile‒water mobile phase. It was also established that the hydrophilic mechanisms are different for the non-aqueous TLC vs. aqueous TLC systems and for the TLC vs. HPLC systems. As a result, different elution orders and separation performances can be expected for the imidazoline and serotonin receptor ligands, depending on the chromatographic system employed.

Published
2022

14. Crystal structure of 4-(3-chlorophenyl)-1-[4-(4-oxoquinazolin-3(4H)-yl)- butyl]piperazin-1-ium chloride trihydrate, (C22H26ClN4O)Cl · 3H2O

Author

Karolak-Wojciechowska J., Fruziński A., Kowalska T., and Kowalski P.

Subjects
Physics, QC1-999, Crystallography, QD901-999
Abstract

C22H32Cl2N4O4, triclinic, P1 (No. 2), a = 7.081(1) Å, b = 13.247(3) Å, c = 13.923(3) Å, α = 102.90(3)0, β = 96.90(3)0, γ = 98.36(3)0, V = 1243.7 Å3, Z = 2, Rgt(F) = 0.066, wRref(F2) = 0.241, T = 293 K.

Published
2003
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36. The Forty-Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot †

Author

Mucaji, P. Atanasov, A.G. Bak, A. Kozik, V. Sieron, K. Olsen, M. Pan, W. Liu, Y. Hu, S. Lan, J. Haider, N. Musiol, R. Vanco, J. Diederich, M. Ji, S. Zitko, J. Wang, D. Agbaba, D. Nikolic, K. Oljacic, S. Vucicevic, J. Jezova, D. Tsantili-Kakoulidou, A. Tsopelas, F. Giaginis, C. Kowalska, T. Sajewicz, M. Silberring, J. Mielczarek, P. Smoluch, M. Jendrzejewska, I. Polanski, J. Jampilek, J.

Abstract

The 46th EuroCongress on Drug Synthesis and Analysis (ECDSA-2017) was arranged within the celebration of the 65th Anniversary of the Faculty of Pharmacy at Comenius University in Bratislava, Slovakia from 5–8 September 2017 to get together specialists in medicinal chemistry, organic synthesis, pharmaceutical analysis, screening of bioactive compounds, pharmacology and drug formulations; promote the exchange of scientific results, methods and ideas; and encourage cooperation between researchers from all over the world. The topic of the conference, “Drug Synthesis and Analysis,” meant that the symposium welcomed all pharmacists and/or researchers (chemists, analysts, biologists) and students interested in scientific work dealing with investigations of biologically active compounds as potential drugs. The authors of this manuscript were plenary speakers and other participants of the symposium and members of their research teams. The following summary highlights the major points/topics of the meeting.

Published
2017

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