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3. Left atrial strain analysis in the realm of pediatric cardiology: Advantages and implications.

Author

Begic, Zijo, Djukic, Milan, Begic, Edin, Aziri, Buena, Mladenovic, Zorica, Iglica, Amer, Sabanovic-Bajramovic, Nirvana, Begic, Nedim, Kovacevic-Preradovic, Tamara, Stanetic, Bojan, and Badnjevic, Almir

Subjects
LEFT heart atrium, PEDIATRIC cardiology, RHEUMATIC heart disease, MULTISYSTEM inflammatory syndrome in children, PROGNOSIS, MITRAL valve
Abstract

BACKGROUND: Left atrial (LA) strain analysis has emerged as a noninvasive technique for assessing LA function and early detection of myocardial deformation. Recently, its application has also shown promise in the pediatric population, spanning diverse cardiac conditions that demand accurate and sensitive diagnostic measures. OBJECTIVE: This research article endeavors to explore the role of LA strain parameters and contribute to the growing body of knowledge in pediatric cardiology, paving the way for more effective and tailored approaches to patient care. METHODS: A comprehensive literature review was conducted to gather evidence from studies using echocardiographic strain imaging techniques across pediatric populations. RESULTS: LA strain parameters exhibited greater sensitivity than conventional atrial function indicators, with early detection of diastolic dysfunction and LA remodeling in pediatric cardiomyopathy, children with multisystem inflammatory syndrome, rheumatic heart disease, as well as childhood renal insufficiency and obesity offering prognostic relevance as potential markers in these pediatric subpopulations. However, there remains a paucity of evidence concerning pediatric mitral valve pathology, justifying further exploration. CONCLUSION: LA strain analysis carries crucial clinical and prognostic implications in pediatric cardiac conditions, with reliable accuracy and sensitivity to early functional changes. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Prognostic Value of D-Dimer in Younger Patients with Pulmonary Embolism

Author

Jovanovic, Ljiljana, primary, Subota, Vesna, additional, Rajkovic, Milena, additional, Subotic, Bojana, additional, Dzudovic, Boris, additional, Novcic, Natasa, additional, Matijasevic, Jovan, additional, Miric, Milica, additional, Salinger, Sonja, additional, Nikolic, Natasa Markovic, additional, Nikolic, Maja, additional, Miloradovic, Vladimir, additional, Kos, Ljiljana, additional, Kovacevic-Preradovic, Tamara, additional, and Obradovic, Slobodan, additional

Published
2023
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8. New-Onset Paroxysmal Atrial Fibrillation in the Setting of Acute Pulmonary Embolism Is Associated with All-Cause Hospital Mortality in Women but Not in Men

Author

Djuric, Ivica, primary, Dzudovic, Boris, additional, Subotic, Bojana, additional, Dzudovic, Jelena, additional, Matijasevic, Jovan, additional, Benic, Marija, additional, Salinger, Sonja, additional, Mitevska, Irena, additional, Kos, Ljiljana, additional, Kovacevic-Preradovic, Tamara, additional, Simovic, Stefan, additional, Miloradovic, Vladimir, additional, Savicic, Tanja, additional, Bozovic, Bjanka, additional, Bulatovic, Nebojsa, additional, Kafedzic, Srdjan, additional, Neskovic, Aleksandar N., additional, Kocev, Nikola, additional, Marinković, Jelena, additional, and Obradovic, Slobodan, additional

Published
2023
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10. Signs and symptoms of acute pulmonary embolism and their predictive value for all-cause hospital death in respect of severity of the disease, age, sex and body mass index: retrospective analysis of the Regional PE Registry (REPER)

Author

Ružičić, Dušan Predrag, primary, Dzudovic, Boris, additional, Matijasevic, Jovan, additional, Benic, Marija, additional, Salinger, Sonja, additional, Kos, Ljiljana, additional, Kovacevic-Preradovic, Tamara, additional, Mitevska, Irena, additional, Neskovic, Aleksandar, additional, Bozovic, Bjanka, additional, Bulatovic, Nebojsa, additional, Miloradovic, Vladimir, additional, Djuric, Ivica, additional, and Obradovic, Slobodan, additional

Published
2023
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12. SYNTAX SCORE II VERSION 2020: EXTERNAL VALIDATION OF PATIENTS TREATED BY CORONARY ARTERY BYPASS GRAFTING IN A SINGLE LARGE VOLUME CARDIO-SURGICAL CENTER

Author

Ostojic, Miodrag C., primary, Arnautovic, Natalija, additional, Nežic, Duško, additional, Raguš, Tatjana, additional, Micovic, Slobodan, additional, Otasevic, Petar, additional, Nikolic, Aleksandra Tomislav, additional, Tasic, Nebojša, additional, Kovacevic-Preradovic, Tamara, additional, Stanetic, Bojan, additional, Unic-Stojanovic, Dragana, additional, Dobric, Milan, additional, Milojevic, Milan, additional, Veljkovic, Stefan, additional, Boskovic, Nikola N., additional, Djokic, Dragoljub, additional, Cucic, Luka, additional, Mihajlovic, Vladimir, additional, Stevuljevic, Jelena Kotur, additional, Ivanovic, Ivan, additional, Balint, Bela, additional, Hinic, Sasa, additional, Boric, Snežana, additional, Djajic, Vlado, additional, and Bojic, Milovan, additional

Published
2023
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13. Prognostic Value of D-Dimer in Younger Patients with Pulmonary Embolism

Author

Jovanovic, Ljiljana, Subota, Vesna, Rajkovic, Milena, Subotic, Bojana, Dzudovic, Boris, Novcic, Natasa, Matijasevic, Jovan, Miric, Milica, Salinger, Sonja, Nikolic, Natasa Markovic, Nikolic, Maja, Miloradovic, Vladimir, Kos, Ljiljana, Kovacevic-Preradovic, Tamara, and Obradovic, Slobodan

Abstract

In patients with pulmonary embolism (PE), the D-dimer assay is commonly utilized as part of the diagnostic workup, but data on D-dimer for early risk stratification and short-term mortality prediction are limited. The purpose of this study was to determine D-dimer levels as a predictive biomarker of PE outcomes in younger (<50 years of age) compared to older patients. We conducted retrospective analysis for 930 patients diagnosed with PE between 2015 and 2019 as part of the Serbian University Multicenter Pulmonary Embolism Registry (SUPER).All patients had D-dimer levels measured within 24 hours of hospital admission. The primary outcome was mortality at 30 days or during hospitalization. Patients were categorized into two groups based on age (≤ 50 and >50 years of age). Younger patients constituted 20.5% of the study cohort. Regarding all-cause mortality, 5.2% (10/191)of patients died in group under the 50 years of age; the short-term all-causemortality was 12.4% (92/739) in older group.We have found that there was significant difference in plasma D-dimer level between patients ≤ 50 years of age and older group (>50), p= 0.006.D-dimer plasma level had good predictive value for the primary outcome in younger patients (c-statistics 0.710; 95% CI, 0.640-0.773; p<0.031). The optimal cutoff level for D-dimer to predict PE-cause death in patients aged > 50 years was found to be 8.8 mg/l FEU(c-statistics 0,580; 95% CI 0.544-0.616; p=0.049). In younger PE patients, D-dimer levels have good prognostic performance for 30-day all-cause mortalityand concentrations above 6.3 mg/l FEU are associated with increased risk of death. D-dimer in patients aged over 50 years does not have predictive ability for all-caused short-term mortality. The relationship between D-dimer and age in patients with PE may need further evaluation.

Published
2023
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14. Prognostic significance of symptomatic deep vein thrombosis in patients with acute symptomatic pulmonary embolism regarding the European Society of Cardiology mortality risk model

Author

OBRADOVIC, Slobodan D., primary, DZUDOVIC, Boris M., additional, SUBOTIC, Bojana N., additional, DZUDOVIC, Jelena M., additional, MATIJASEVIC, Jovan A., additional, BENIC, Marija D., additional, TROBOK, Jadranka L., additional, PEKOVIC, Sandra M., additional, SALINGER-MARTINOVIC, Sonja S., additional, JOVANOVIC, Ljiljana Z., additional, KOS, Ljiljana V., additional, KOVACEVIC-PRERADOVIC, Tamara, additional, SIMOVIC, Stefan M., additional, MILORADOVIC, Vladimir M., additional, KOVACEVIC-KUZMANOVIC, Ana M., additional, MRDJAN, Tanja D., additional, BOZOVIC, Bjanka Z., additional, BULATOVIC, Nebojsa S., additional, KAFEDZIC, Srdjan V., additional, PANCEVACKI, Sasa S., additional, and NESKOVIC, Aleksandar N., additional

Published
2022
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15. Pulmonary embolism bleeding score index (PEBSI): A new tool for the detection of patients with low risk for major bleeding on thrombolytic therapy

Author

Obradovic, Slobodan, primary, Subotic, Bojana, additional, Dzudovic, Boris, additional, Matijasevic, Jovan, additional, Dzudovic, Jelena, additional, Salinger-Martinovic, Sonja, additional, Miloradovic, Vladimir, additional, Kovacevic-Preradovic, Tamara, additional, Marinkovic, Jelena, additional, and Neskovic, Aleksandar, additional

Published
2022
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16. Predictive value of heart failure with reduced versus preserved ejection fraction for outcome in pulmonary embolism

Author

Gluvic Zoran, Dzudovic Boris, Kafedzic Srdjan, Mladenovic Zorica, Nikolic Maja, Zec Nenad, Neskovic Aleksandar, Pekovic Sandra, Matijasevic Jovan, Obradovic Slobodan, Subotic Bojana, Kovacevic-Kuzmanovic Ana, Srdanovic Ilija, Jovanovic Ljiljana, Salinger-Martinovic Sonja, Miloradovic Vladimir, Markovic-Nikolic Natasa, Bokan Aleksandar, Pancevacki Sasa, Kovacevic-Preradovic Tamara, Konstantinides Stavros, Trobok Jadranka, and Kos Ljiljana

Subjects
Ejection fraction, medicine.medical_specialty, Heart failure, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Original Research Articles, Internal medicine, Diseases of the circulatory (Cardiovascular) system, Medicine, Original Research Article, 030212 general & internal medicine, Mortality, Risk factor, business.industry, Pulmonary embolism, Hazard ratio, Atrial fibrillation, medicine.disease, 3. Good health, Blood pressure, RC666-701, Cardiology, Cardiology and Cardiovascular Medicine, business, Heart failure with preserved ejection fraction
Abstract

Aims This study aimed to investigate whether the risk of short‐term mortality is different in pulmonary embolism (PE) patients who have heart failure with reduced ejection fraction (HFrEF) as compared with those with heart failure with preserved ejection fraction (HFpEF). Methods and results Predictive value of HFrEF or HFpEF for 7‐day (intrahospital) and 30‐day all‐cause mortality was determined in the cohort of 1055 out of 1201 consecutive acute PE patients from the Serbian multicentre PE registry. Patients were classified into either HFrEF or HFpEF group, according to guideline‐proposed criteria. A 7‐day (intrahospital) and 30‐day all‐cause mortality was 18.5% vs. 7.3% vs. 4.5% (P

Published
2020

17. The Timing of Death in Acute Pulmonary Embolism Patients Regarding the Mortality Risk Stratification at Admission to the Hospital

Author

Obradovic, Slobodan, primary, Dzudovic, Boris, additional, Pruszcyk, Piotr, additional, Djuric, Ivica, additional, Subotic, Bojana, additional, Matijasevic, Jovan, additional, Benic, Marija, additional, Salinger, Sonja, additional, Kos, Ljiljana, additional, Kovacevic-Preradovic, Tamara, additional, Mitevska, Irena, additional, Kafedzic, Srdjan, additional, Neskovic, Aleksandar, additional, Bozovic, Bjanka, additional, Bulatovic, Nebojsa, additional, and Miloradovic, Vladimir, additional

Published
2022
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18. The New-Onset Paroxysmal Atrial Fibrillation in Acute Pulmonary Embolism is Associated with All-Cause Hospital Death in Women But Not in Men

Author

Djuric, Ivica, primary, Dzudovic, Boris, additional, Subotic, Bojana, additional, Dzudovic, Jelena, additional, Matijasevic, Jovan, additional, Benic, Marija, additional, Pekovic, Sandra M., additional, Salinger, Sonja, additional, Mitevska, Irena, additional, Kos, Ljiljana V., additional, Kovacevic-Preradovic, Tamara, additional, Simovic, Stefan M., additional, Miloradovic, Vladimir, additional, Kovacevic-Kuzmanovic, Ana M., additional, Savicic, Tanja D., additional, Bozovic, Bjanka, additional, Bulatovic, Nebojsa, additional, Kafedzic, Srdjan, additional, Pancevacki, Sasa S., additional, Neskovic, Aleksandar, additional, Kocev, Nikola I., additional, Marinković, Jelena M., additional, and Obradovic, Slobodan, additional

Published
2022
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19. Stress Echo 2030: The Novel ABCDE-(FGLPR) Protocol to Define the Future of Imaging

Author

Picano, Eugenio, Ciampi, Quirino, Cortigiani, Lauro, Arruda-Olson, Adelaide M., Borguezan-Daros, Clarissa, Silva Pretto, José Luis de Castro, Cocchia, Rosangela, Bossone, Eduardo, Merli, Elisa, Kane, Garvan C., Varga, Albert, Agoston, Gergely, Scali, Maria Chiara, Morrone, Doralisa, Simova, Iana, Samardjieva, Martina, Boschenko, Alla, Ryabova, Tamara, Vrublevsky, Alexander, Palinkas, Attila, Palinkas, Eszter D., Sepp, Robert, Torres, Marco A.R., Villarraga, Hector R., Kovacevic Preradovic, Tamara, Citro, Rodolfo, Amor, Miguel, Mosto, Hugo, Salamè, Michael, Leeson, Paul, Mangia, Cristina, Gaibazzi, Nicola, Tuttolomondo, Domenico, Prota, Constantina, Peteiro-Vázquez, Jesús, Van de Heyning, Caroline M., D'Andrea, Antonello, Rigo, Fausto, Nikolic, Aleksandra, Ostojic, Miodrag, Lowenstein, Jorge, Arbucci, Rosina, Lowenstein Haber, Diego M., Merlo, Pablo M., Wierzbowska-Drabik, Karina, Kasprzak, Jaroslaw D., Haberka, Maciej, Camarozano, Ana Cristina, Ratanasit, Nithima, Mori, Fabio, D'Alfonso, Maria Grazia, Tassetti, Luigi, Milazzo, Alessandra, Olivotto, Iacopo, Marchi, Alberto, Rodríguez-Zanella, Hugo, Zagatina, Angela, Padang, Ratnasari, Dekleva, Milica, Djordievic-Dikic, Ana, Boskovic, Nikola, Tesic, Milorad, Giga, Vojislav, Belesin, Branko, Di Salvo, Giovanni, Lorenzoni, Valentina, Cameli, Matteo, Mandoli, Giulia Elena, Bombardini, Tonino, Caso, Pio, Celutkiene, Jelena, Barbieri, Andrea, Benfari, Giovanni, Bartolacelli, Ylenia, Malagoli, Alessandro, Bursi, Francesca, Mantovani, Francesca, Villari, Bruno, Russo, Antonello, De Nes, Michelle, Carpeggiani, Clara, Monte, Ines, Re, Federica, Cotrim, Carlos, Bilardo, Giuseppe, Saad, Ariel K., Karuzas, Arnas, Matuliauskas, Dovydas, Colonna, Paolo, Antonini-Canterin, Francesco, Pepi, Mauro, Pellikka, Patricia A., Picano, Eugenio, Ciampi, Quirino, Cortigiani, Lauro, Arruda-Olson, Adelaide M., Borguezan-Daros, Clarissa, Silva Pretto, José Luis de Castro, Cocchia, Rosangela, Bossone, Eduardo, Merli, Elisa, Kane, Garvan C., Varga, Albert, Agoston, Gergely, Scali, Maria Chiara, Morrone, Doralisa, Simova, Iana, Samardjieva, Martina, Boschenko, Alla, Ryabova, Tamara, Vrublevsky, Alexander, Palinkas, Attila, Palinkas, Eszter D., Sepp, Robert, Torres, Marco A.R., Villarraga, Hector R., Kovacevic Preradovic, Tamara, Citro, Rodolfo, Amor, Miguel, Mosto, Hugo, Salamè, Michael, Leeson, Paul, Mangia, Cristina, Gaibazzi, Nicola, Tuttolomondo, Domenico, Prota, Constantina, Peteiro-Vázquez, Jesús, Van de Heyning, Caroline M., D'Andrea, Antonello, Rigo, Fausto, Nikolic, Aleksandra, Ostojic, Miodrag, Lowenstein, Jorge, Arbucci, Rosina, Lowenstein Haber, Diego M., Merlo, Pablo M., Wierzbowska-Drabik, Karina, Kasprzak, Jaroslaw D., Haberka, Maciej, Camarozano, Ana Cristina, Ratanasit, Nithima, Mori, Fabio, D'Alfonso, Maria Grazia, Tassetti, Luigi, Milazzo, Alessandra, Olivotto, Iacopo, Marchi, Alberto, Rodríguez-Zanella, Hugo, Zagatina, Angela, Padang, Ratnasari, Dekleva, Milica, Djordievic-Dikic, Ana, Boskovic, Nikola, Tesic, Milorad, Giga, Vojislav, Belesin, Branko, Di Salvo, Giovanni, Lorenzoni, Valentina, Cameli, Matteo, Mandoli, Giulia Elena, Bombardini, Tonino, Caso, Pio, Celutkiene, Jelena, Barbieri, Andrea, Benfari, Giovanni, Bartolacelli, Ylenia, Malagoli, Alessandro, Bursi, Francesca, Mantovani, Francesca, Villari, Bruno, Russo, Antonello, De Nes, Michelle, Carpeggiani, Clara, Monte, Ines, Re, Federica, Cotrim, Carlos, Bilardo, Giuseppe, Saad, Ariel K., Karuzas, Arnas, Matuliauskas, Dovydas, Colonna, Paolo, Antonini-Canterin, Francesco, Pepi, Mauro, and Pellikka, Patricia A.

Abstract

[Abstract] With stress echo (SE) 2020 study, a new standard of practice in stress imaging was developed and disseminated: the ABCDE protocol for functional testing within and beyond CAD. ABCDE protocol was the fruit of SE 2020, and is the seed of SE 2030, which is articulated in 12 projects: 1-SE in coronary artery disease (SECAD); 2-SE in diastolic heart failure (SEDIA); 3-SE in hypertrophic cardiomyopathy (SEHCA); 4-SE post-chest radiotherapy and chemotherapy (SERA); 5-Artificial intelligence SE evaluation (AI-SEE); 6-Environmental stress echocardiography and air pollution (ESTER); 7-SE in repaired Tetralogy of Fallot (SETOF); 8-SE in post-COVID-19 (SECOV); 9: Recovery by stress echo of conventionally unfit donor good hearts (RESURGE); 10-SE for mitral ischemic regurgitation (SEMIR); 11-SE in valvular heart disease (SEVA); 12-SE for coronary vasospasm (SESPASM). The study aims to recruit in the next 5 years (2021-2025) ≥10,000 patients followed for ≥5 years (up to 2030) from ≥20 quality-controlled laboratories from ≥10 countries. In this COVID-19 era of sustainable health care delivery, SE2030 will provide the evidence to finally recommend SE as the optimal and versatile imaging modality for functional testing anywhere, any time, and in any patient.

Published
2021

20. Predictive value of heart failure with reduced versus preserved ejection fraction for outcome in pulmonary embolism

Author

Obradovic, Slobodan, primary, Dzudovic, Boris, additional, Subotic, Bojana, additional, Matijasevic, Jovan, additional, Mladenovic, Zorica, additional, Bokan, Aleksandar, additional, Trobok, Jadranka, additional, Pekovic, Sandra, additional, Salinger‐Martinovic, Sonja, additional, Jovanovic, Ljiljana, additional, Kos, Ljiljana, additional, Kovacevic‐Preradovic, Tamara, additional, Nikolic, Maja, additional, Miloradovic, Vladimir, additional, Kovacevic‐Kuzmanovic, Ana, additional, Zec, Nenad, additional, Markovic‐Nikolic, Natasa, additional, Srdanovic, Ilija, additional, Gluvic, Zoran, additional, Kafedzic, Srdjan, additional, Pancevacki, Sasa, additional, Neskovic, Aleksandar, additional, and Konstantinides, Stavros, additional

Published
2020
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23. Sex‐related difference in the prognostic value of syncope for 30‐day mortality among hospitalized pulmonary embolism patients

Author

Dzudovic, Boris, primary, Subotic, Bojana, additional, Novicic, Natasa, additional, Matijasevic, Jovan, additional, Trobok, Jadranka, additional, Miric, Milica, additional, Salinger‐Martinovic, Sonja, additional, Stanojevic, Dragana, additional, Nikolic, Maja, additional, Miloradovic, Vladimir, additional, Markovic Nikolic, Natasa, additional, Dekleva, Milica, additional, Lepojevic Stefanovic, Danijela, additional, Kos, Ljiljana, additional, Kovacevic Preradovic, Tamara, additional, and Obradovic, Slobodan, additional

Published
2020
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24. Renal dysfunction as intrahospital prognostic indicator in acute pulmonary embolism

Author

Salinger-Martinovic, Sonja, primary, Dimitrijevic, Zorica, additional, Stanojevic, Dragana, additional, Momčilović, Stefan, additional, Kostic, Tomislav, additional, Koracevic, Goran, additional, Subotic, Bojana, additional, Dzudovic, Boris, additional, Stefanovic, Branislav, additional, Matijasevic, Jovan, additional, Miric, Milica, additional, Markovic-Nikolic, Natasa, additional, Nikolic, Maja, additional, Miloradovic, Vladimir, additional, Kos, Ljiljana, additional, Kovacevic-Preradovic, Tamara, additional, Srdanovic, Ilija, additional, Stanojevic, Jelena, additional, and Obradovic, Slobodan, additional

Published
2020
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28. . The role of N-terminal pro-brain natriuretic peptide in the assessment of right ventricular dysfunction in patients with acute pulmonary embolism: Results from Serbian University Pulmonary Embolism Registry (Super)

Author

Kos, Ljiljana, primary, M. Stanetic, Bojan, additional, Kovacevic-Preradovic, Tamara, additional, Ostojic, Miodrag, additional, Jovanovic, Ljiljana, additional, Subota, Vesna, additional, Stavric, Milena, additional, Subotic, Bojana, additional, Dzudovic, Boris, additional, Novicic, Natasa, additional, Matijasevic, Jovan, additional, Miric, Milica, additional, Salinger, Sonja, additional, Markovic-Nikolic, Natasa, additional, Nikolic, Maja, additional, Miloradovic, Vladimir, additional, Marinkovic, Jelena, additional, Kocev, Nikola, additional, and Obradovic, Slobodan, additional

Published
2019
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29. Biomarkers for the prediction of early pulmonary embolism related mortality in spontaneous and provoked thrombotic disease

Author

Jovanovic, Ljiljana, primary, Subota, Vesna, additional, Stavric, Milena, additional, Subotic, Bojana, additional, Dzudovic, Boris, additional, Novicic, Natasa, additional, Matijasevic, Jovan, additional, Miric, Milica, additional, Salinger, Sonja, additional, Markovic-Nikolic, Natasa, additional, Nikolic, Maja, additional, Miloradovic, Vladimir, additional, Kos, Ljiljana, additional, Kovacevic-Preradovic, Tamara, additional, Marinkovic, Jelena, additional, Kocev, Nikola, additional, and Obradovic, Slobodan, additional

Published
2019
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31. ApPropRiateness of myOcardial revascUlarization assessed by SYNTAX Scores in patients with type 2 diabetes melliTus: the PROUST study.

Author

Stanetic, Bojan M., Ostojic, Miodrag, Kovacevic-Preradovic, Tamara, Kos, Ljiljana, Stanetić, Kosana, Nikolic, Aleksandra, Bojic, Milovan, and Huber, Kurt

Subjects
TYPE 2 diabetes, MYOCARDIAL revascularization, PEOPLE with diabetes, CORONARY artery bypass, PERCUTANEOUS coronary intervention
Abstract

Introduction: Results of currently available trials have shown divergent outcomes in diabetic patients undergoing percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). Current guidelines do not recommend PCI in patients with diabetes and a SYNTAX score ≥ 23. Aim: To compare all-cause 4-year mortality after revascularization for complex coronary artery disease (CAD) in diabetics. Material and methods: The study group comprised consecutive patients with three-vessel CAD and/or unprotected left main CAD (≥ 50% diameter stenosis) without major hemodynamic instability, who were treated in two institutions with PCI or referred for CABG. Results: Out of 342 diabetics, 177 patients underwent PCI and 165 patients were referred for CABG. The incidence of all-cause death was different between diabetics treated with PCI or CABG at 4 years (16/177, 9.0% vs. 26/165, 15.8%, respectively, p = 0.03). The difference was not evident in non-diabetics (PCI: 41/450, 9.1% vs. CABG: 19/249, 7.6%, p = 0.173). In diabetics, there was a higher incidence of all-cause mortality in PCI patients with intermediate-high (≥ 23) SYNTAX scores compared with those with low (0-22) SYNTAX scores (10/56, 17.9% vs. 6/121, 5.0%, respectively, p < 0.01). On the other hand, diabetics who underwent CABG showed similar mortality rates irrespective of the SYNTAX scores (SYNTAX 0-22: 3/29, 10.3%; SYNTAX ≥ 23: 23/136, 11.9%, p = 0.46). In the subgroup analysis, there was no interaction according to presence or absence of left main CAD (p for interaction = 0.12) as well as according to diabetes status (p for interaction = 0.38), whereas gender and SYNTAX scores were differentiators between PCI and CABG with a p for interaction < 0.1. Conclusions: Our analysis supports recent evidence that diabetes is not a differentiator between PCI and CABG. [ABSTRACT FROM AUTHOR]

Published
2020
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33. The timing of death in acute pulmonary embolism patients regarding the mortality risk stratification at admission to the hospital.

Author

Obradovic S, Dzudovic B, Pruszczyk P, Djuric I, Subotic B, Matijasevic J, Benic M, Salinger S, Kos L, Kovacevic-Preradovic T, Mitevska I, Kafedzic S, Neskovic A, Bozovic B, Bulatovic N, and Miloradovic V

Abstract

Background: The management of patients with acute pulmonary embolism (aPE) depends on the severity of aPE. The timing of death in various aPE risk subgroups is only partially known., Methods: 1618 patients with an objectively established aPE diagnosis with computed tomography pulmonary angiography enrolled in the regional PE registry were included in the study. According to ESC criteria, patients were stratified at admission to the hospital in four risk strata. The timing of PE-related and non-PE-related deaths was analyzed regarding mortality risk., Results: PE-related, and non-PE-related hospital death rates were 1.1 % and 1.5 % in low, 1.1 % and 4.8 % in intermediate-low, 8.1 % and 5.9 % in intermediate-high, and 27.7 % and 6.9 % in high-risk groups, respectively. The median time of PE-related and non-PE-related death across the PE mortality risk were: 4 (1.7-7.5) and 7.0 (4-14.7) days in low, 1.5 (1.0-9.5) and 11.5 (2.0-21.0) days in intermediate-low, 4.0 (2.0-9.0) and 9.0 (5.7-18.2) days in intermediate-high, 2.0 (1.0-4.75) and 7.0 (3.0-21.2) days in high-risk subgroups. 48.2 % and 17.1 % of patients who died in the high and intermediate-high risks died during the first hospital day. After the 6th hospitalization day, PE-related deaths were recorded in 43.9 % of deaths from intermediate-high and 17.9 % from high-risk subgroups., Conclusion: PE-related mortality is prominent on the first hospitalization day in high and intermediate-high-risk PE. A substantial proportion of intermediate-high and high-risk patient's PE deaths occurred after the first 6 days of hospitalization., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors.)

Published
2023
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34. Feasibility and value of two-dimensional volumetric stress echocardiography.

Author

Bombardini T, Zagatina A, Ciampi Q, Cortigiani L, D'Andrea A, Borguezan Daros C, Zhuravskaya N, Kasprzak JD, Wierzbowska-Drabik K, de Castro E Silva Pretto JL, Djordjevic-Dikic A, Beleslin B, Petrovic M, Boskovic N, Tesic M, Monte IP, Simova I, Vladova M, Boshchenko A, Ryabova T, Citro R, Amor M, Vargas Mieles PE, Arbucci R, Dodi C, Rigo F, Gligorova S, Dekleva M, Severino S, Torres MA, Salustri A, Rodrìguez-Zanella H, Costantino FM, Varga A, Agoston G, Bossone E, Ferrara F, Gaibazzi N, Rabia G, Celutkiene J, Haberka M, Mori F, D'Alfonso MG, Reisenhofer B, Camarozano AC, Salamé M, Szymczyk E, Wejner-Mik P, Wdowiak-Okrojek K, Kovacevic Preradovic T, Lattanzi F, Morrone D, Scali MC, Ostojic M, Nikolic A, Re F, Barbieri A, DI Salvo G, Colonna P, DE Nes M, Paterni M, Merlo PM, Lowenstein J, Carpeggiani C, Gregori D, and Picano E

Subjects
Aged, Dobutamine, Echocardiography methods, Feasibility Studies, Humans, Male, Middle Aged, Echocardiography, Stress methods, Heart Failure
Abstract

Background: Stroke volume response during stress is a major determinant of functional status in heart failure and can be measured by two-dimensional (2-D) volumetric stress echocardiography (SE). The present study hypothesis is that SE may identify mechanisms underlying the change in stroke volume by measuring preload reserve through end-diastolic volume (EDV) and left ventricular contractile reserve (LVCR) with systolic blood pressure and end-systolic volume (ESV)., Methods: We enrolled 4735 patients (age 63.6±11.3 years, 2800 male) referred to SE for known or suspected coronary artery disease (CAD) and/or heart failure (HF) in 21 SE laboratories in 8 countries. In addition to regional wall motion abnormalities (RWMA), force was measured at rest and peak stress as the ratio of systolic blood pressure by cuff sphygmomanometer/ESV by 2D with Simpson's or linear method. Abnormal values of LVCR (peak/rest) based on force were ≤1.10 for dipyridamole (N.=1992 patients) and adenosine (N.=18); ≤2.0 for exercise (N.=2087) or dobutamine (N.=638)., Results: Force-based LVCR was obtained in all 4735 patients. Lack of stroke volume increase during stress was due to either abnormal LVCR and/or blunted preload reserve, and 57% of patients with abnormal LVCR nevertheless showed increase in stroke volume., Conclusions: Volumetric SE is highly feasible with all stresses, and more frequently impaired in presence of ischemic RWMA, absence of viability and reduced coronary flow velocity reserve. It identifies an altered stroke volume response due to reduced preload and/or contractile reserve.

Published
2022
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35. ApPropRiateness of myOcardial revascUlarization assessed by SYNTAX Scores in patients with type 2 diabetes melliTus: the PROUST study.

Author

Stanetic BM, Ostojic M, Kovacevic-Preradovic T, Kos L, Stanetić K, Nikolic A, Bojic M, and Huber K

Abstract

Introduction: Results of currently available trials have shown divergent outcomes in diabetic patients undergoing percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). Current guidelines do not recommend PCI in patients with diabetes and a SYNTAX score ≥ 23., Aim: To compare all-cause 4-year mortality after revascularization for complex coronary artery disease (CAD) in diabetics., Material and Methods: The study group comprised consecutive patients with three-vessel CAD and/or unprotected left main CAD (≥ 50% diameter stenosis) without major hemodynamic instability, who were treated in two institutions with PCI or referred for CABG., Results: Out of 342 diabetics, 177 patients underwent PCI and 165 patients were referred for CABG. The incidence of all-cause death was different between diabetics treated with PCI or CABG at 4 years (16/177, 9.0% vs. 26/165, 15.8%, respectively, p = 0.03). The difference was not evident in non-diabetics (PCI: 41/450, 9.1% vs. CABG: 19/249, 7.6%, p = 0.173). In diabetics, there was a higher incidence of all-cause mortality in PCI patients with intermediate-high (≥ 23) SYNTAX scores compared with those with low (0-22) SYNTAX scores (10/56, 17.9% vs. 6/121, 5.0%, respectively, p < 0.01). On the other hand, diabetics who underwent CABG showed similar mortality rates irrespective of the SYNTAX scores (SYNTAX 0-22: 3/29, 10.3%; SYNTAX ≥ 23: 23/136, 11.9%, p = 0.46). In the subgroup analysis, there was no interaction according to presence or absence of left main CAD ( p for interaction = 0.12) as well as according to diabetes status ( p for interaction = 0.38), whereas gender and SYNTAX scores were differentiators between PCI and CABG with a p for interaction < 0.1., Conclusions: Our analysis supports recent evidence that diabetes is not a differentiator between PCI and CABG., Competing Interests: The authors declare no conflict of interest., (Copyright: © 2020 Termedia Sp. z o. o.)

Published
2020
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36. Surgical treatment of left ventricular pseudoaneurysm.

Author

Mujanovic E, Bergsland J, Avdic S, Stanimirovic-Mujanovic S, Kovacevic-Preradovic T, and Kabil E

Subjects
Aneurysm, False diagnostic imaging, Chest Pain etiology, Electrocardiography, Heart Rupture, Post-Infarction physiopathology, Heart Rupture, Post-Infarction surgery, Heart Ventricles pathology, Humans, Male, Middle Aged, Myocardial Infarction complications, Treatment Outcome, Ventricular Dysfunction, Left etiology, Ventricular Dysfunction, Left surgery, Aneurysm, False surgery, Cardiovascular Surgical Procedures methods, Chest Pain diagnostic imaging, Heart Rupture, Post-Infarction diagnostic imaging, Heart Ventricles diagnostic imaging, Myocardial Infarction physiopathology, Ventricular Dysfunction, Left diagnostic imaging
Abstract

Introduction: Left ventricular pseudoaneurysm is a rare condition because in most instances ventricular free-wall rupture leads to fatal pericardial tamponade. Rupture of the free wall of the left ventricle is a cata-strophic complication of myocardial infarction, occurring in approximately 4% of pa-tients with infarcts, resulting in immediate collapse of the patient and electromechanical dissociation. In rare cases the rupture is contained by pericardial and fibrous tissue, and the result is a pseudoaneurysm. The left ventricular pseudoaneurysm contains only pericardial and fibrous elements in its wall-no myocardial tissue. Because such aneurysms have a strong tendency to rupture, this disorder may lead to death if it is left surgically untreated., Case Report: In this case report, we present a patient who underwent successful repair of a left ventricular pseudoaneurysm, which followed a myocardial infarction that was caused by occlusion of the left circumflex coronary artery. Although repair of left ventricular pseudoaneurysm is still a surgical challenge, it can be performed with acceptable results in most patients.

Published
2014
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