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Tema ovog diplomskog rada je izrada aplikacije za Nacionalni park sa interaktivnom kartom. U teoretskom dijelu rada obradit će se osnove izrade aplikacije odnosno predprodukcija i produkcija te istraživanje tržišta postojećih aplikacija na tu temu. Proći će se kroz postupak određivanja komponenti aplikacije, fontova te palete boja i samog stila aplikacije. U praktičnom će dijelu rada biti izrađen dizajn sa postojećim idejnim rješenjima logotipa Nacionalnog parka te će biti ukomponiran u vlastiti dizajn aplikaciije. Po završetku izrade prototipa u alatu Figma bit će provedeno testiranje aplikacije na određenoj skupini ljudi koji će potom popuniti popratnu anketu kako bi se dobile povratne informacije o funkcionalnosti navigacije te preglednosti same aplikacije. Aplikacija će se bazirati na interakrivnoj karti koja će prikazivati atrakcije koje se nalaze u parku, mogućnost odabira lokacija te stvaranje željene rute obilaska parka. Na karti će također biti označena biljna i životinjska staništa te osnovne informacije o istima. Isto tako će biti prikazane lokacije za odmor, piknik, toaleti, štandovi sa autohtinim domaćim proizvodima, restorani, kafići, ulazi u park kao i prodajna mjesta ulaznica. Na karti će biti vidljiva mjesta polaska turističkih brodova i autobusa te vozni red u parku. Aplikacija će sadržavati povijest parka, kontakt te osnovne inforamcije koje su potrebne za obilazak parka.

Folklor i glazba koja se veže uz njega sastavni su dio tradicije koja je važna u stvaranju nacionalnog identiteta jednog naroda. Da se ona ne bi izgubila, bitno je istraživati i čuvati tradicijsku građu. Upravo tome je i posvećen ovaj završni rad. Sam naziv rada govori da će se on usmjeriti na folklor i glazbu dvaju mjesta – Gradišta, odakle je i autorica rada, i Županje. Kroz osam poglavlja, prikazana su najvažnija obilježja dvaju mjesta. Na početku je objašnjen sam pojam folklora, nakon čega slijedi prikaz njegovih segmenata: glazbe, tradicijske odjeće, bećarcaca.. Predstavljena su i mjesta o kojima se radi te skupine i udruge koje se bave folklornim aktivnostima. Folklore and the music associated with it are part of a tradition that is very important for creating national identity of Croatian people. In order for it not to be lost, it is important to research and preserve traditional structure. This final paper is dedicater exactly to that. The very title of the work says that it is directed to folklore and the music of two places – Gradište, from wich the author comes, and Županja. Through the eight chapters, the most important folklore characteristics of the two places are shown. At the very beginning, the concept of the folklore is explained, followed by a presentation of its segments: music, traditional clothing, „bećarci“.. The mentioned places are also presented, as well as groups engaged in folklore activities.

We present a case of transient form of type 1 pseudohypoaldosteronism (S-PHA) in a 1, 5-month- old male infant who presented with lethargy, failure to thrive, severe hyponatremia (Na=118 mmol/L), hypochloremia (Cl=93 mmol/L) and fever due to urinary tract infection. Potassium levels were normal. Markedly elevated serum aldosterone level and elevated serum renin confirmed the diagnosis of pseudohypoaldosteronism. Renal ultrasound showed grade III hydronephrosis on the left kidney while contrast-enhanced voiding urosonography excluded the existence of vesicoureteral reflux which raised suspicion of opstructive uropathy on the level of vesicoureteral junction. Serum sodium normalized after several days of intravenous fluids and antibiotic therapy after which oral supplementation of sodium was introduced. Levels of 17-hydroxyprogesterone, ACTH, cortisole and TSH were normal. Functional MR urography conducted at the age of 3 months confirmed the diagnosis of primary congenital obstructive megaureter and the infant was referred to a pediatric surgeon. Although a rare occurence, S-PHA can be a potentially life threatening condition in infants if not recognized and treated adequately. Therefore, serum concentrations of electrolytes should be obtained in every child with diagnosed obstructive anomaly of the urinary tract and/or acute cystopyelonephritis. On the other hand, every child with diagnosed S-PHA should be evaluated for obstructive anomaly of the urinary tract.

Cilj rada bio je evaluirati najčešće korištenu terapiju za bol u ambulantama Zavoda za hitnu medicinu Vukovarsko-srijemske županije u 2021. godini i utvrditi razlike u dijagnozama po spolu.

Cilj rada je analizirati izvore financiranja privatnog sektora kulturnih i kreativnih industrija u Republici Hrvatskoj. U teorijskom dijelu dan je pregled mogućih izvora financiranja privatnog sektora kulturnih i kreativnih industrija, u obliku kredita, programa, natječaja, sponzorstva i crowdfunding kampanja te je analizirano stanje za vrijeme pandemije COVID-19. Pritom su postavljena dva istraživačka pitanja: kako je pandemija uzrokovana virusom COVID-19 utjecala na poslovanje gospodarskih subjekata u kulturnim i kreativnim industrijama te koliki je udio samofinanciranja u poslovanju poslovnih subjekata kulturnih i kreativnih industrija od 2016. do 2020. godine. U okviru empirijskog dijela rada pomoću financijske analize provedena je analiza uspješnosti poslovanja poslovnih subjekata privatnog sektora kulturnih i kreativnih industrija te su prikazani rezultati. Zaključak istraživanja je kako je pandemija imala negativan utjecaj na poslovanje tvrtki te kako su se u najvećoj mjeri financirali iz rezervi i vlastitih sredstava. Korištene metode u radu su: deskriptivna metoda, metoda komparacije, induktivna metoda, metoda analize i sinteze, metoda financijske analize i statistička metoda The purpose of this paper is to analyse the sources of funding for the private sector of cultural and creative industries in Croatia. The theoretical part provides an overview of possible sources of funding for the private sector of cultural and creative industries, in the form of loans, programs, tenders, sponsorships and crowdfunding campaigns, and analyzes the situation during the COVID-19 pandemic. Two research questions were set: how the pandemic caused by the COVID-19 virus affected the business of economic entities in the cultural and creative industries, and what is the share of self-financing of business entities in the cultural and creative industries from 2016. to 2020.. Within the empirical part of the paper, the analysis of business performance of business entities of the private sector of cultural and creative industries was performed using financial analysis, and the results are presented. The conclusion of the research is that pandemic had a negative impact on business in cultural and creative industries and that they have been financed by their own reserves and self-financing. The methods used in the paper are: descriptive method, comparison method, inductive method, analysis and synthesis method, financial analysis method and statistical method.

ECMO (Extra Corporeal Membrane Oxygenation - izvantjelesna membranskaoksigenacija) je metoda liječenja koja omogućava privremenu mehaničku cirkulacijsku potporubolesnicima s respiracijskom i/ili srčanom insuficijencijom. Implantacija ECMO-a je indicirana kod bolesnika kod kojih su iscrpljene druge mogućnosti liječenja. Može služiti kao most premaoporavku, drugoj mehaničkoj potpori ili transplantaciji.Indikacije za liječenje ECMO potporom imaju bolesnici s navedenom patologijom kod kojih je stanje reverzibilno i očekuje se poboljšanje u funkciji i radu vitalnih organa koji su ugroženi. Osnovni cilj liječenja ECMO potporom je održavanje srčane i plućne funkcije kako bi se održala hemodinamska stabilnost bolesnika i osigurala zadovoljavajuća dostava kisika svim tkivima i organima.Uloga medicinske sestre u skrbi za bolesnika na ECMo potpori je ključna jer je medicinska sestra u jedinici intenzivnog liječenja 24 sata uz bolesnika te uz standardne sestrinske postupke primjenjuje i sva znanja u svrhu otkrivanja i spriječavanja nastalih komplikacija od strane bolesnika i ECMO sustava tijekom liječenja. Izuzetno je važna kontinuirana edukacija medicinskih sestarau jedinici intenzivnog liječenja i obnavljanje usvojenih znanja kako bi bile u mogućnosti pratit napredak tehnologije i metoda liječenja u svrhu pružanja što kvalitetnije skrbi bolesniku. U ovom diplomskom radu dati će se uvod u metode i oblike ECMO liječenja te će se opisati komplikacije koje mogu nastati tijekom ecmo liječenja od strane bolesnika i komplikacije od strane ecmo sustava. Posljednje poglavlje biti će posvećeno ulozi medicinske sestre u skrbi za bolesnika na ECMO potpori. Za kraj rada biti će dat prikaz slučaja koji je uspješno liječen ECMO potporom., ECMO (Extra Corporeal Membrane Oxygenation) is a treatment method that provides temporary mechanical circulatory support to patients with respiratory and / or heart failure. ECMO implantation is indicated in patients in who mother treatment options have been exhausted. It can serve as a bridge to recovery, other mechanical support, or transplantation. Indications for ECMO-supported treatment are in patients with this pathology in whom the condition is reversible an dimprovement in the function and function of vital organs that are at risk is expected. The primary goal of ECMO support treatment is to maintain cardiac and pulmonary function to maintain the hemodynamic stability of patients and to ensure satisfactory oxygen delivery to all tissues and organs. The role of the nurse inpatient care on ECMO support is crucial because the nurse is in the intensive care unit 24 hours a day with the patient and with standard nursing procedures applies all knowledge to detect and prevent complications by patients and ECMO system during treatment. It is extremely important to continuously educate nurses in the intensive care unit and renew the a cquired knowledge in order to beable to monitor the progress of technology and treatment methods in order to provide the best possible care to the patient. This thesis will provide an introduction to the methods and forms of ECMO treatment and will describe the complications that may occur during ecmo treatment by patients and complications by the ecmo system. The last chapter will be devoted to the role of the nurse in patient care on ECMO support. At the end of the paper, a case report that has been successfully treated with ECMO support will be presented.

Cilj istraživanja bio je ispitati odnos dimenzija privrženosti (izbjegavajuća i anksiozna), dimenzija ljubomore (kognitivna, ponašajna i emocionalna), interpersonalnog nadzora na društvenim mrežama i zadovoljstva romantičnim odnosom. Također se željela ispitati mogućnost predviđanja zadovoljstva vezom na temelju dimenzija privrženosti, dimenzija ljubomore te interpersonalnog nadzora. U istraživanju je sudjelovalo ukupno N = 387 sudionika (158 žena i 229 muškaraca) u dobi od 18 do 30 godina koji su trenutno u romantičnom odnosu. Sudionici su ispunjavali Sociodemografski upitnik konstruiran za potrebe ovoga istraživanja, Inventar iskustava u bliskim vezama – skraćena verzija (Fraley, Waller i Brennan, 2000; Kamenov i Jelić, 2003), Skalu interpersonalnog elektronskog nadzora (Tokunaga, 2011), Multidimenzionalnu skalu ljubomore – kratka forma (Elphinston, Feeney i Noller, 2011) te Upitnik procjene zadovoljstva vezom (Hendrick, 1988). Rezultati korelacijske analize pokazali su da postoji značajna povezanost između zadovoljstva vezom i obje dimenzije nesigurne privrženosti te kognitivne i ponašajne ljubomore. Emocionalna ljubomora i zadovoljstvo odnosom su u pozitivnoj korelaciji. Utvrđena je pozitivna korelacija između interpersonalnog nadzora i svih dimenzija ljubomore te negativna između nadzora i zadovoljstva odnosom. Provedena hijerarhijska regresijska analiza pokazala je da su dimenzija izbjegavajuće privrženosti te kognitivna i ponašajna dimenzija ljubomore značajni negativni prediktori zadovoljstva odnosom. Konačno, opisani su dobiveni nalazi, ograničenja istraživanja te prijedlozi za buduća istraživanja. The aim of this study was to examine relations between attachment dimensions (avoidance and anxiety), jealousy dimensions (cognitive, emotional and behavioural), interpersonal surveillance and relationship satisfaction. We also wanted to investigate the possibility of predicting relationship satisfaction based on attachment dimensions, jealousy dimensions and interpersonal surveillance. A total of N = 387 participants (158 female, 229 male) between ages of 19 to 30 who are in a romantic relationship completed Sociodemographic questionnaire that was designed for the purpose of this research, Experiences in Close Relationships Scale – Revised (Fraley, Waller and Brennan, 2000; Kamenov and Jelić, 2003), Interpersonal Electronic Surveillance Scale (Tokunaga, 2011), The Short Form of the Multidimensional Jealousy Scale (Elphinston, Feeney and Noller, 2011) and Relationship Assessment Scale (Hendrick, 1988). Correlation analysis was conducted to establish relationship between relationship satisfaction and both (avoidance and anxiety) attachment dimensions, jealousy dimensions and interpersonal surveillance. The results showed that relationship satisfaction was negatively related to insecure attachment, cognitive and behavioural jealousy and interpersonal surveillance. The emotional jealousy was positively related to relationship satisfaction. Also, all three jealousy dimensions were positively correlated to interpersonal dimension. Furthermore, regression analysis has shown that avoidance attachment dimension, cognitive and behavioural jealousy negatively predicted relationship satisfaction. Finally, findings of this research are further explained, as well as limitations and recommendations for future studies.

Predstavljamo slučaj tranzitornog oblika pseudohipoaldosteronizma tipa1 u muškog dojenčeta dobi mjesec i pol koje se prezentiralo letargijom, nenapredovanjem na tjelesnoj masi te teškom hiponatremijom (Na=118 mmol/L), hipokloremijom (Cl=93 mmol/L) i vrućicom u sklopu urinarne infekcije. Razina kalija je bila uredna. Značajno povišena koncentracija aldosterona i povišena aktivnost serumskog renina potvrdili su dijagnozu pseudohipoaldosteronizma. Ultrazvuk mokraćnog sustava utvrdio je hidronefrozu III stupnja lijevog bubrega dok je kontrastom pojačana mikcijska urosonografija isključila postojanje vezikoureteralnog refluksa te postavila sumnju na opstruktivnu uropatiju na razini vezikoureteralnog ušća. Razina serumskog natrija normalizirala se nakon nekoliko dana parenteralne rehidracije i antibiotske terapije nakon čega je uvedena peroralna suplementacija natrija. Koncentracije 17-hidroksiprogesterona, ACTH, kortizola i TSH su bile uredne. Funkcionalna MR urografija u dobi 3 mjeseca potvrdila je dijagnozu primarnog kongenitalnog opstruktivnog megauretera te je dojenče upućeno dječjem kirurgu. Iako rijedak, S- PHA može biti potencijalno životno ugrožavajuće stanje ukoliko se ne prepozna na vrijeme i ne liječi adekvatno. Sukladno tome, serumska koncentracije elektrolita trebaju se provjeriti kod svakog djeteta s opstruktivnom anomalijom urinarnog sustava i/ili cistopijelonefritisom. S druge strane, svako dijete s dijagnosticiranim S- PHA treba obraditi u svrhu utvrđivanja podležeće anomalije mokraćnog sustava.

INTRODUCTION: Cystic kidney disease (CyKD) is one of the most important causes of chronic kidney disease (CKD) in children. Multiple kidney cysts can occur unilaterally (e.g. multicystic dysplastic kidney- MCDK) or bilaterally (e.g. autosomal dominant or autosomal recessive polycystic kidney disease) due to genetic or non-genetic (developmental or acquired) disorders. Here we present a rare case of combined polycystic kidney disease (PCKD) and MCDK in a pediatric patient. CASE REPORT: The patient was admitted to our hospital for the first time at the age of two. She was normally developed (weight: 10.8 kg – 19th percentile, height: 90 cm- 80th percentile) with blood pressure (BP) within normal limits. Estimated glomerular filtration rate (eGFR) at that time was 70.2 mL/min with elevated albumin/creatinine ratio 5, 2 mg/mmol and she was diagnosed with G2A2 stage of CKD. During her prenatal period oligohydramnios and polycystic kidneys were detected. At birth a palpable mass of the left abdomen was found. First sonography after birth showed hydronephrosis of the right kidney and multiple cysts on the left kidney. Micturating cystourethrography was negative for vesicoureteral reflux. Initial magnetic resonance imaging (MRI) showed enlargement of both kidneys with multiple cysts of various sizes on the left kidney and lesser number of diffuse renal cysts on the right kidney. Cysts weren’t found neither on the brain nor on the other abdominal organs. Echocardiography was normal. Family history was negative for kidney diseases. The abdominal and kidney ultrasound of both parents and older brother was normal. At the age of two dynamic scintigraphy with Tc-99m revealed unfunctional left kidney leading to diagnosis of MCDK. Follow-up ultrasound showed progressive involution of the MCDK left and multiple very small cysts that generate abnormal parenchymal echogenicity (e.g., „salt-and-pepper sign”) on the right kidney. Functional MRI urography showed nonfunctional MCDK left and functional right kidney with lesser number of small cysts. At the age of four arterial hypertension (130/70 mmHg) was diagnosed and ACE inhibitor was introduced. There were no signs of liver disease. Abdominal ultrasound revealed no cysts of liver, spleen or pancreas. Gynecological ultrasound and ophtalmological examination were also normal. Due to parental disapproval, genetic testing wasn’t performed. CONCLUSION We conclude that, although rare, different types of CyKD can be associated and we should consider it when setting the diagnosis. Due to vast differential diagnosis and overlapping clinical presentations of CyKD genetic testing should be performed whenever possible.

Introduction: Crohn’s disease (CD) is a chronic inflammatory bowel disease that affects the entire digestive tube. Orofacial granulomatosis describes changes in the oral cavity without the involvement of the gastrointestinal tract, although some patients may have active subclinical disease or potential for developing CD. In patients with diagnosed CD changes of the oral cavity are called oral Crohn’s disease, and they can occur as side effects of pharmacological therapy, malabsorption, or nutritional deficits. Treatment is complex and involves treatment of primary intestinal disease combined with dental treatment. Methods: In this report, we describe the case of a girl with CD who developed severe chronic lesions in the oral cavity. Results: A 17-year- old girl suffers from an extensive form of CD which initially presented as pancolitis with sideropenic anemia. Over the years she had frequent relapses and pharmacotherapy was often modified. Clinical course seemed favorable, but typical changes persisted in the ileocaecal region (intersphinteric fistula). At the age of 16, she developed severe gingivitis and periodontitis with ulcer-like lesions. She was initially treated by periodontologist, but progressive changes aroused suspicion for oral Crohn’s disease. Antibiotic therapy showed partial effect and significant improvement was recorded only during short periods of corticosteroid therapy (local or systemic). Histologically the changes were described as hyperplastic gingivitis with chronic inflammatory changes, without granuloma. Conclusion: With this case, we wanted to recall another (extra- intestinal?) CD manifestation which can significantly impair the patient’s quality of life and requires cooperation between gastroenterologists and dental specialists.

We present a case of the transient form of type 1 pseudohypoaldosteronism (S-PHA) in a 1, 5-month- old male infant who presented with lethargy, failure to thrive, severe hyponatremia (Na=118 mmol/L), hypochloremia (Cl=93 mmol/L), and fever due to urinary tract infection. Material and methods: Potassium levels were normal. Markedly elevated serum aldosterone level and elevated serum renin confirmed the diagnosis of pseudohypoaldosteronism. Renal ultrasound showed grade III hydronephrosis on the left kidney while contrast-enhanced voiding urosonography excluded the existence of vesicoureteral reflux which raised suspicion of obstructive uropathy on the level of vesicoureteral junction. Results: Serum sodium normalized after several days of intravenous fluids and antibiotic therapy after which oral supplementation of sodium was introduced. Levels of 17-hydroxyprogesterone, ACTH, cortisol, and TSH were normal. Functional MR urography conducted at the age of 3 months confirmed the diagnosis of primary congenital obstructive megaureter and the infant was referred to a pediatric surgeon. Conclusions: Although a rare occurrence, S-PHA can be a potentially life- threatening condition in infants if not recognized and treated adequately. Therefore, serum concentrations of electrolytes should be obtained in every child with a diagnosed obstructive anomaly of the urinary tract and/or acute cystopyelonephritis. On the other hand, every child with diagnosed S-PHA should be evaluated for the obstructive anomaly of the urinary tract.

Refeeding syndrome (RFS) describes a potentially fatal shift in electrolytes in severely malnourished patients receiving rapid and excessive food re-introduction. It is a result of hormonal and metabolic disturbances. There are various clinical and laboratory features with hypophosphatemia being the most common one. Elevation in liver function tests is also frequently seen. Patients with anorexia are a high-risk group for developing RFS. The aim of the study was to investigate the incidence and clinical features of RFS among hospitalized patients, as well as the severity of malnutrition (Z-score, BMI). This study is a retrospective analysis of medical documentation of patients diagnosed with anorexia nervosa (restricting (ANRT) and binge eating/purging (ANBP) subtype), eating disorder NOS (EDNOS), and avoidant/ restrictive food intake disorder (ARFID) who were admitted to our Centre for eating disorders in children and adolescents during a 5 year period (2014-2018). We analyzed the age, gender, duration of the disease before admittance, anthropometric data (BMI and Z-score), average weight loss, the need for nasogastric (NG) tube feeding, and phosphate supplementation. For statistical analysis we used t-test. 256 patients (232 female) aged 6-20 years (median 15+/-2.06) of which 43% were diagnosed with ANRT, 10% ANBP, 8% ARFID, 39% with EDNOS were included in the study. The average duration of the disease at the time of admittance was 13.25+/-13.43 months. The average BMI Z-score was -1.97 +/-1.63 average weight loss was 20+/-9.76% initial body weight (IBW). Hypophosphatemia was found in 15.6% of patients, of which 65% received phosphate supplements by oral or intravenous route depending on phosphate serum concentration. Elevated liver enzymes due to RFS were found in 9.3% of patients. In total RFS in some form developed in 23% of patients. The average BMI Z-score of patients that developed RFS was -2.6+/-1.89, average weight loss was 23.9+/-9.85% of IBW. Both variables were significantly different (p

Cilj ovoga rada bio je ispitati utjecaj dodatka antioksidansa na aromatski sastav crnog vina Cabernet Sauvignon nakon 12 mjeseci starenja u bocama. Aromatske komponente i njihova koncentracija u vinu određeni su pomoću plinske kromatografije s masenom spektrometrijom uz prethodnu mikroekstrakciju na čvrstoj fazi (SPME-GC/MS). Cabernet Sauvignon karakteriziraju sljedeći spojevi arome: hlapive masne kiseline, viši alkoholi, terpeni, acetatni i etilni esteri te norizoprenoidi. Smanjena koncentracija sumporovog dioksida rezultirala je smanjenjem koncentracije određenih aromatskih spojeva, dok je dodatkom glutationa njihova koncentracija u vinu ostala očuvana. The aim of this study was to investigate the effect of antioxidants addition (sulfur dioxide and glutathione) on the aroma composition of Cabernet Sauvignon after 12 months of bottle ageing. Aromatic compounds and their concentration in wine were analyzed by gas chromatography-mass spectrometry with solid-phase microextraction (SPME-GC/MS). Cabernet Sauvignon is characterized by aroma compounds: volatile fatty acids, higher alcohols, terpenes, acetate and ethyl esters and norisoprenoids. The reduced concentration of sulfur dioxide resulted in a decrease of aromatic compounds, while glutathion addition preserved their concentration in wine.

Uvod: Entezitisu pridruženi artritis (ErA) posebni je oblik juvenilnog idiopatskog artritisa (JIA) koji predstavlja nediferencirani juvenilni spondiloartritis (jSpA). Uz artritis perifernih zglobova, jedna od najvažnijih značajki jSpA je upala enteza i/ili aksijalnog skeleta. I dok se u odraslih bolesnika sa SpA crijevo sve češće navodi kao polazište i/ ili ishodište subkliničke upale, učestalost i raširenost upalnog procesa u crijevima djece s ErA još uvijek nije poznata, uglavnom zbog izazova vezanih uz provođenje invazivnih pretraga neophodnih za otkrivanje upale crijeva u djece. Cilj našeg istraživanja stoga je bio procijeniti koncentraciju fekalnog kalprotektina (fCAL), surogatnog markera upale crijeva, u djece s različitim oblicima artritisa. Ispitanici i metode: U ovom presječnom istraživanju sudjelovalo je ukupno 71 dijete s postavljenom dijagnozom oligo i poliartikularnog oblika JIA (N=29), ErA (N=26), PsA (N=4) te neupalnim muskuloskeltnim stanjima (N=12). Svi bolesnici s ErA uključeni su neovisno o prisutnosti gastrointestinalnih simptoma, dok su ostali uključeni u slučaju izraženih simptoma. Uz standardne laboratorijske pretrage, svim sudionicima izmjeren je fCAL, a svim bolesnicima s ErA, kao i ostalima koji su se žalili na upalnu bol u leđima, učinjen je MR SIZ- ova. U svih bolesnika s ErA izmjerena je aktivnost bolesti pomoću jSpADA, a u ostalih oligo i poli JIA bolesnika pomoću JADAS-a. Rezultati: Medijan koncentracije fCAL bio je najviši u skupini bolesnika s ErA (33.2 mg/kg, p=0.043), s značajnom razlikom između bolesnika s aktivnom i inaktivnom bolesti (20.0 mg/kg vs 57.4 mg/kg, p=0.01), kao i između bolesnika s prisutnim znakovima upale te bolesnika s urednim nalazom MR-a (22.6 mg/kg vs 54.3 mg/ kg, p=0.048). Koncentracije fCAL nisu se značajno razlikovale između bolesnika koji su koristili i koji nisu koristili NSAIL-ove (23 mg/kg vs 20 mg/kg, p=0.18), mada je uočena slaba koleracija s trajanjem korištenja (r=0.25, p=0.03). Zaključak: Subklinička upala crijeva nije vezana samo uz odrasle bolesnike sa SpA, već i uz djecu s nediferenciranom oblikom jSpA, osobito ako je uz to prisutna aktivna bolest i/ili znakovi upale SIZ-ova na MR-u.

Any discrimination or exclusion based on sexual orientation for the purpose of reducing equali- ty before the law, as well as providing preferential treatment on these grounds, constitutes sexual orientation discrimination . This paper will, inter alia, address the rights of same-sex partners vis-à-vis the rights of heterosexual partners, with the aim of analyzing the current stage of the European perspective in the area where the legal arrangements of certain EU Member States EU AND COMPARATIVE LAW ISSUES AND CHALLENGES SERIES (ECLIC) – ISSUE 41272(hereinafter: MS) will be presented by a comparative method. It is precisely these issues that have been decided by the Court of Justice of the European Union (hereinafter: CJEU), from which the major problems in the area of sexual orientation discrimination are identified. In the view of the CJEU, in order for a treatment to be characterized as discrimination on the basis of sexual orientation, a community of same-sex partners must be legalized in a MS. Only when such a legal framework exists can the CJEU decide whether there is a basis for discrimi- nation. Such an interpretation begs the question, what about states that do not have any legal framework that recognizes the same- sex life community? The first part of the paper will analyze international and European standards of protection against sexual orientation discrimination, and after that, the current level of same-sex rights in the EU will be briefly presented. The sec-ond part of the paper will be based on analysis of the impact of CJEU decisions on changes in Romanian legislation in the field of recognizing the effect of same-sex marriage, concluded in another MS, as well as an analysis of the process of recognizing the effect of same-sex marriage in the Republic of Croatia (hereinafter: Croatia) In addition, the paper will also analyze the judgment of the Constitutional Court of the Republic of Croatia (hereinafter: CCRC) regard-ing discrimination on the grounds of sexual orientation observed in the positive regulation gov-erning the issue of foster care. Based on these analyzes, de lege ferenda guidelines will be given at the end of the paper in order to reduce the possibility of sexual orientation discrimination