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6. Factor V Leiden mutation and high FVIII are associated with an increased risk of VTE in women with breast cancer during adjuvant tamoxifen - Results from a prospective, single center, case control study

Author

Kovač, Mirjana, Kovac, Zeljko, Tomasević, Zorica, Vucicević, Slavko, Đorđević, Valentina, Pruner, Iva, Radojković, Dragica, Kovač, Mirjana, Kovac, Zeljko, Tomasević, Zorica, Vucicević, Slavko, Đorđević, Valentina, Pruner, Iva, and Radojković, Dragica

Abstract

Background: Estimates of the risk ratio of tamoxifen-associated venous thromboembolism(VTE) in breast cancer patients range from 2.4 to 7.1. The occurrence of thrombosis in patients with breast cancer complicates the clinical condition and causes a change of treatment. Our study was conducted in order to investigate the influence of patient-related risk factors for thrombosis development in breast cancer patients whose treatment included adjuvant tamoxifen. Methods: The prospective, single center, case control study included 150 breast cancer women, 50 whom developed venous thrombosis during adjuvant tamoxifen and 100 whom did not have thrombosis, as a control group. Patient-related risk factors such as: age, body mass index, previous VTE, varicose veins, concomitant diseases, the presence of prothrombotic mutations (FV Leiden, FII G20210A) and FVIII activity were evaluated in both groups. Results: In respect of prothrombotic mutations, the FV Leiden mutation was present in a higher number of women from the VTE group (10/50 vs 7/100; P = 0.020). Additionally, FVIII activity was significantly higher in the VTE group; median (IQR), of 1.79 (0.69) vs 1.45 (0.55); P lt 0.001 and more women in this group (24/50 vs 34/100) had increased FVIII activity; P = 0.020. In those women with FVIII gt 1.5 IU/ml, who were carriers of prothrombotic mutations, an OR of 3.76 (CI 95% 1.276-11.096; P = 0.016) was obtained for VTE. Conclusion: The results of our study showed that the factor V Leiden mutation and high FVIII are associated with an increased risk of VTE in women with breast cancer during adjuvant tamoxifen.

Published
2015

7. Young patients with breast cancer: Comparison of molecular characteristics of pregnancy associated breast cancer with non-pregnancy associated breast cancer.

Author

Tomasevic, Zorica, primary, Tomasevic, Zoran, additional, Kovac, Zeljko, additional, Milovanovic, Zorka, additional, Minic, Ivana, additional, Milosevic, Snezana, additional, Bozovic-Spasojevic, Ivana, additional, Zdrale, Zdravko, additional, Markovic, Ivan, additional, and Dzodic, Radan, additional

Published
2015
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