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770 results on '"Kovács B"'

1. Soluble Biomarkers of Osteoporosis and Osteoarthritis, from Pathway Mapping to Clinical Trials: An Update

Author

Nagy EE, Nagy-Finna C, Popoviciu H, and Kovács B

Subjects
osteoarthritis, osteoporosis, biomarkers, Geriatrics, RC952-954.6
Abstract

Előd Ernő Nagy,1 Csilla Nagy-Finna,1,2 Horațiu Popoviciu,2 Béla Kovács1 1Department of Biochemistry and Environmental Chemistry, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Târgu Mureș, Romania; 2Department M4, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Târgu Mureș, Romania; Rheumatology Clinic, Clinical Emergency Hospital, Târgu Mureș, RomaniaCorrespondence: Előd Ernő NagyDepartment of Biochemistry and Environmental Chemistry, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Gheorghe Marinescu Street No. 38, Târgu Mureș 540139, RomaniaTel +40-265 215551 int. 187Email elod.nagy@umfst.roAbstract: Serum biomarkers of osteoarticular diseases have been in the limelight of current clinical research trends. Laboratory validation of defined and candidate biomarkers for both osteoarthritis and osteoporosis is of key importance for future decisional algorithms in the diagnosis, monitoring, and prognosis of these diseases. The current guidelines recommend the use of collagen degradation remnants, eg, CTX-I and CTX-II, in the complementary diagnosis of both osteoporosis and osteoarthritis. Besides the collagen degradation markers, enzymes that regulate bone and articular metabolism are useful in the clinical evaluation of osteoarticular pathologies. Along these, several other recommended and new nominee molecules have been recently studied. Wnts and Wnt-related molecules have a cardinal role in the bone-joint homeostasis, making them a promising target not only for pharmaceutical modulation, but also to be considered as soluble biomarkers. Sclerostin and dickkopf, two inhibitor molecules of the Wnt/β-catenin signaling, might have a dual role in the assessment of the clinical manifestations of the osteoarticular unit. In osteoarthritis, besides fragments of collagen type II many pathway-related molecules have been studied and proposed for biomarker validation. The most serious limitation is that a significant proportion of studies lack statistical power due to the reduced number of cases enrolled. Serum biomarkers of bone and joint turnover markers represent an encouraging possibility for the diagnosis and prognosis of osteoarticular diseases, although further studies and laboratory validations should be carried out as to solely rely on them.Keywords: osteoarthritis, osteoporosis, biomarkers

Published
2020

3. A multi-epoch, multi-wavelength study of the classical FUor V1515 Cyg approaching quiescence

Author

Szabó, Zs. M., Kóspál, Á., Ábrahám, P., Park, S., Siwak, M., Green, J. D., Pál, A., Acosta-Pulido, J. A., Lee, J. -E., Ibrahimov, M., Grankin, K., Kovács, B., Bora, Zs., Bódi, A., Cseh, B., Csörnyei, G., Drózdz, Marek, Hanyecz, O., Ignácz, B., Kalup, Cs., Könyves-Tóth, R., Krezinger, M., Kriskovics, L., Ogloza, Waldemar, Ordasi, A., Sárneczky, K., Seli, B., Szakáts, R., Szing, A., Vida, K., and Vinkó, J.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

Historically, FU Orionis-type stars are low-mass, pre-main sequence stars. The members of this class experience powerful accretion outbursts and remain in an enhanced accretion state for decades or centuries. V1515 Cyg, a classical FUor, started brightening in the 1940s and reached its peak brightness in the late 1970s. Following a sudden decrease in brightness it stayed in a minimum state for a few months, then started a brightening for several years. We present results of our ground-based photometric monitoring complemented with optical/NIR spectroscopic monitoring. Our light curves show a long-term fading with strong variability on weekly and monthly time scales. The optical spectra show P Cygni profiles and broad blue-shifted absorption lines, common properties of FUors. However, V1515 Cyg lacks the P Cygni profile in the Ca II 8498 \r{A} line, a part of the Ca infrared triplet (IRT), formed by an outflowing wind, suggesting that the absorbing gas in the wind is optically thin. The newly obtained near-infrared spectrum shows the strengthening of the CO bandhead and the FeH molecular band, indicating that the disk has become cooler since the last spectroscopic observation in 2015. The current luminosity of the accretion disk dropped from the peak value of 138 $L_{\odot}$ to about 45 $L_{\odot}$, suggesting that the long-term fading is also partly caused by the dropping of the accretion rate., Comment: 26 pages, 19 figure, accepted for publication in The Astrophysical Journal

Published
2022
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13. Global organization of metabolic fluxes in the bacterium, Escherichia coli

Author

Almaas, E., Kovacs, B., Vicsek, T., Oltvai, Z. N., and Barabasi, A. -L.

Subjects
Quantitative Biology - Molecular Networks, Condensed Matter - Disordered Systems and Neural Networks, Quantitative Biology - Cell Behavior
Abstract

Cellular metabolism, the integrated interconversion of thousands of metabolic substrates through enzyme-catalyzed biochemical reactions, is the most investigated complex intercellular web of molecular interactions. While the topological organization of individual reactions into metabolic networks is increasingly well understood, the principles governing their global functional utilization under different growth conditions pose many open questions. We implement a flux balance analysis of the E. coli MG1655 metabolism, finding that the network utilization is highly uneven: while most metabolic reactions have small fluxes, the metabolism's activity is dominated by several reactions with very high fluxes. E. coli responds to changes in growth conditions by reorganizing the rates of selected fluxes predominantly within this high flux backbone. The identified behavior likely represents a universal feature of metabolic activity in all cells, with potential implications to metabolic engineering., Comment: 15 pages 4 figures

Published
2004
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14. EVALUATION OF FUSARIUM RESISTANCE TESTS ON MAIZE APPLIED IN THE NATIONAL VARIETY REGISTRATION IN HUNGARY

Author

null Kovács B, null Pécs M, Joszt- Takács N, and null Szőke C

Subjects
General Medicine
Abstract

With respect to maize, as one of the most significant agricultural plant species in the world, resistance to Fusarium is particularly important since chemical control against it is difficult. For food safety, the National Food Chain Safety Office of Hungary (NFCSO) tests the resistance of varieties reported for national registration against Fusarium stalk and ear rot (Fusarium spp.). In this study, we present the results obtained based on the current methodology of resistance test. Based on the comparison of Fusarium infection of the variety trial set up in 12 different production sites (Variety Trial Station) in years under test (2014, 2015 and 2016), we test the effects of the harvest year and trial site based on the rate of infection and the susceptibility/resistance of 19 hybrids tested for 3 years. There is significant difference between harvest years, trial sites, and hybrids based on the infection of stalk and ear rot. Based on our findings, the current methodology can be successfully applied to determining the level of field resistance.

Published
2023
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19. Exploring the impact of high shear mixing process parameters on the physical characteristics of excipient powder blend by design of experiments

Author

Kovács Béla, Tőkés Erzsébet Orsolya, Kelemen Éva Katalin, Zöldi Katalin, Suba Edit, Kovács-Deák Boglárka, Székely-Szentmiklósi István, Boda Francisc, and Casian Tibor

Subjects
placebo, design of experiments, full factorial, manufacturing technology optimization, Medicine
Abstract

Dry-route manufacturing technology development poses challenges to pharmaceutical technology research specialists, relying on active substance characteristics, excipient selection, and parameter optimization. Amongst various technological possibilities high shear mixing generally ensures dosage uniformity and tablet dissolution through influential shear forces, potentially enhancing dry powder blend processability. This study explores the processability of a placebo formulation within the quality by design framework to address some of the aforementioned challenges.

Published
2024
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26. Spectroscopic quantification of the nanoparticle production efficiency of copper wire explosion.

Author

Égerházi, L., Kovács, B., and Szörényi, T.

Subjects
*COPPER wire, *PARTICLE size distribution, *POLYDISPERSE media, *COPPER oxide, *LOGNORMAL distribution, *UNDERWATER explosions, *DUST explosions, *MIE scattering
Abstract

Wire explosion is a technically straightforward green method for nanoparticle production; however, the determination of polydisperse and multimodal particle size distribution and thereby the assessment of the efficiency of the process pose serious challenges. Fitting extinction spectra derived from the Mie theory to the measured extinction spectra of colloidal solutions produced by the explosion of copper wires of 70 μm diameter and 20 mm length by discharging a capacitor of 435 nF charged to voltages ranging from 4 to 12 kV in an aqueous environment allows for determining the size distribution of the particles in the 10–300 nm diameter range and provides information on their oxidation state as well. In underwater wire explosion of copper, the vast majority of the nanoparticles transforms into copper oxides already during the process. The size distribution remains bimodal throughout the whole charging voltage range investigated. The nanoparticles follow a lognormal size distribution with a mode at 30 nm, while the fine particle population extending from 100 to 300 nm in diameter is dominated by rather normally distributed copper droplets with modes at 160–170 nm. The energy injected into the wire controls the individual concentration of both the fine and nanoparticles with the modes and ranges remaining hardly affected. The number concentration of the nanoparticles increases monotonically with the energy, spanning more than one order of magnitude. The throughput assessed by the total mass of the nanoparticles divided by the total mass of all species identified in the sol within the 0–300 nm diameter range increases monotonically from 1% at 4 kV up to 41% at 12 kV, revealing that wire explosion can be optimized for efficient nanoparticle production. [ABSTRACT FROM AUTHOR]

Published
2021
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30. Prostate Cancer Screening

Author

Tenke, P., Horti, J., Balint, P., Kovacs, B., Schlag, P. M., editor, Senn, H. -J., editor, Kleihues, P., editor, Stiefel, F., editor, Groner, B., editor, Wallgren, A., editor, Rentchnik, P., editor, Ramon, Jacob, editor, and Denis, Louis J., editor

Published
2007
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31. A Multi-epoch, Multiwavelength Study of the Classical FUor V1515 Cyg Approaching Quiescence

Author

Szabó, Zs. M., primary, Kóspál, Á., additional, Ábrahám, P., additional, Park, S., additional, Siwak, M., additional, Green, J. D., additional, Pál, A., additional, Acosta-Pulido, J. A., additional, Lee, J.-E., additional, Ibrahimov, M., additional, Grankin, K., additional, Kovács, B., additional, Bora, Zs., additional, Bódi, A., additional, Cseh, B., additional, Csörnyei, G., additional, Dróżdż, Marek, additional, Hanyecz, O., additional, Ignácz, B., additional, Kalup, Cs., additional, Könyves-Tóth, R., additional, Krezinger, M., additional, Kriskovics, L., additional, Ogłoza, Waldemar, additional, Ordasi, A., additional, Sárneczky, K., additional, Seli, B., additional, Szakáts, R., additional, Sódor, Á., additional, Szing, A., additional, Vida, K., additional, and Vinkó, J., additional

Published
2022
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