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1. Development and Validation of a Simple Tool for Predicting Pandemic-Related Psychological Distress Among Health Care Workers

Author

Adorjan, Kristina, Dong, Mark Sen, Wratil, Paul R., Schmacke, Niklas A., Weinberger, Tobias, Steffen, Julius, Osterman, Andreas, Choukér, Alexander, Mueller, Tonina T., Jebrini, Tarek, Wiegand, Hauke Felix, Tüscher, Oliver, Lieb, Klaus, Hornung, Veit, Falkai, Peter, Klein, Matthias, Keppler, Oliver T., and Koutsouleris, Nikolaos

Published
2024
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4. Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis

Author

Meyhoefer, Inga, Sprenger, Andreas, Derad, David, Grotegerd, Dominik, Leenings, Ramona, Leehr, Elisabeth J., Breuer, Fabian, Surmann, Marian, Rolfes, Karen, Arolt, Volker, Romer, Georg, Lappe, Markus, Rehder, Johanna, Koutsouleris, Nikolaos, Borgwardt, Stefan, Schultze-Lutter, Frauke, Meisenzahl, Eva, Kircher, Tilo T. J., Keedy, Sarah S., Bishop, Jeffrey R., Ivleva, Elena I., McDowell, Jennifer E., Reilly, James L., Hill, Scot Kristian, Pearlson, Godfrey D., Tamminga, Carol A., Keshavan, Matcheri S., Gershon, Elliot S., Clementz, Brett A., Sweeney, John A., Hahn, Tim, Dannlowski, Udo, and Lencer, Rebekka

Published
2024
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5. Multimodal workflows optimally predict response to repetitive transcranial magnetic stimulation in patients with schizophrenia: a multisite machine learning analysis

Author

Dong, Mark Sen, Rokicki, Jaroslav, Dwyer, Dominic, Papiol, Sergi, Streit, Fabian, Rietschel, Marcella, Wobrock, Thomas, Müller-Myhsok, Bertram, Falkai, Peter, Westlye, Lars Tjelta, Andreassen, Ole A., Palaniyappan, Lena, Schneider-Axmann, Thomas, Hasan, Alkomiet, Schwarz, Emanuel, and Koutsouleris, Nikolaos

Published
2024
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8. Transdiagnostic subgroups of cognitive impairment in early affective and psychotic illness

Author

Wenzel, Julian, Badde, Luzie, Haas, Shalaila S., Bonivento, Carolina, Van Rheenen, Tamsyn E., Antonucci, Linda A., Ruef, Anne, Penzel, Nora, Rosen, Marlene, Lichtenstein, Theresa, Lalousis, Paris Alexandros, Paolini, Marco, Stainton, Alexandra, Dannlowski, Udo, Romer, Georg, Brambilla, Paolo, Wood, Stephen J., Upthegrove, Rachel, Borgwardt, Stefan, Meisenzahl, Eva, Salokangas, Raimo K. R., Pantelis, Christos, Lencer, Rebekka, Bertolino, Alessandro, Kambeitz, Joseph, Koutsouleris, Nikolaos, Dwyer, Dominic B., and Kambeitz-Ilankovic, Lana

Published
2024
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9. Brain texture as a marker of transdiagnostic clinical profiles in patients with recent-onset psychosis and depression

Author

Korda, Alexandra I., Andreou, Christina, Ruef, Anne, Hahn, Lisa, Schmidt, André, Dannlowski, Udo, Kambeitz-Ilankovic, Lana, Dwyer, Dominic B., Kambeitz, Joseph, Wenzel, Julian, Ruhrmann, Stephan, Wood, Stephen J., Salokangas, Raimo K. R., Pantelis, Christos, Schultze-Lutter, Frauke, Meisenzahl, Eva, Brambilla, Paolo, Selvaggi, Pierluigi, Bertolino, Alessandro, Hietala, Jarmo, Upthegrove, Rachel, Lalousis, Paris Alexandros, Riecher-Rössler, Anita, Davatzikos, Christos, Lencer, Rebekka, Koutsouleris, Nikolaos, and Borgwardt, Stefan

Published
2024
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10. Validation of the Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) questionnaire for adults

Author

Solmi, Marco, Thompson, Trevor, Estradé, Andrés, Agorastos, Agorastos, Radua, Joaquim, Cortese, Samuele, Dragioti, Elena, Leisch, Friedrich, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schlögelhofer, Monika, Aschauer, Elena, Schneeberger, Andres, Huber, Christian G, Hasler, Gregor, Conus, Philippe, Do Cuénod, Kim Q, von Känel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre-Michel, Krebs, Marie-Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Żydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kamiński, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan-Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Manková, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Saccon, Diego, Righi, Elena, Monaco, Francesco, Croatto, Giovanni, Cereda, Guido, Demurtas, Jacopo, Brondino, Natascia, Veronese, Nicola, Enrico, Paolo, Politi, Pierluigi, Ciappolino, Valentina, Pfennig, Andrea, Bechdolf, Andreas, Meyer-Lindenberg, Andreas, Kahl, Kai G, Domschke, Katharina, Bauer, Michael, Koutsouleris, Nikolaos, Winter, Sibylle, Borgwardt, Stefan, Bitter, Istvan, Balazs, Judit, Czobor, Pál, Unoka, Zsolt, Mavridis, Dimitris, Tsamakis, Konstantinos, Bozikas, Vasilios P, Tunvirachaisakul, Chavit, Maes, Michael, Rungnirundorn, Teerayuth, Supasitthumrong, Thitiporn, Haque, Ariful, Brunoni, Andre R, Costardi, Carlos Gustavo, Schuch, Felipe Barreto, Polanczyk, Guilherme, Luiz, Jhoanne Merlyn, Fonseca, Lais, Aparicio, Luana V, Valvassori, Samira S, Nordentoft, Merete, Vendsborg, Per, Hoffmann, Sofie Have, Sehli, Jihed, Sartorius, Norman, Heuss, Sabina, Guinart, Daniel, Hamilton, Jane, Kane, John, Rubio, Jose, and Sand, Michael

Subjects
Clinical and Health Psychology, Health Sciences, Psychology, Mental Health, Behavioral and Social Science, Brain Disorders, Depression, Mental health, Good Health and Well Being, Humans, Adult, Reproducibility of Results, Pandemics, COVID-19, Surveys and Questionnaires, Outcome Assessment, Health Care, Factor Analysis, Statistical, Psychometrics, Covid-19, Pandemic, COH-FIT, Survey: P-factor: well-being: mental health: psychiatry: psychometric, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundThe Collaborative Outcome study on Health and Functioning during Infection Times (COH-FIT; www.coh-fit.com) is an anonymous and global online survey measuring health and functioning during the COVID-19 pandemic. The aim of this study was to test concurrently the validity of COH-FIT items and the internal validity of the co-primary outcome, a composite psychopathology "P-score".MethodsThe COH-FIT survey has been translated into 30 languages (two blind forward-translations, consensus, one independent English back-translation, final harmonization). To measure mental health, 1-4 items ("COH-FIT items") were extracted from validated questionnaires (e.g. Patient Health Questionnaire 9). COH-FIT items measured anxiety, depressive, post-traumatic, obsessive-compulsive, bipolar and psychotic symptoms, as well as stress, sleep and concentration. COH-FIT Items which correlated r ≥ 0.5 with validated companion questionnaires, were initially retained. A P-score factor structure was then identified from these items using exploratory factor analysis (EFA) and confirmatory factor analyses (CFA) on data split into training and validation sets. Consistency of results across languages, gender and age was assessed.ResultsFrom >150,000 adult responses by May 6th, 2022, a subset of 22,456 completed both COH-FIT items and validated questionnaires. Concurrent validity was consistently demonstrated across different languages for COH-FIT items. CFA confirmed EFA results of five first-order factors (anxiety, depression, post-traumatic, psychotic, psychophysiologic symptoms) and revealed a single second-order factor P-score, with high internal reliability (ω = 0.95). Factor structure was consistent across age and sex.ConclusionsCOH-FIT is a valid instrument to globally measure mental health during infection times. The P-score is a valid measure of multidimensional mental health.

Published
2023

11. Alterations of Functional Connectivity Dynamics in Affective and Psychotic Disorders

Author

Betz, Linda, Erkens, Anne, Gussmann, Eva, Haas, Shalaila, Hasan, Alkomiet, Hoff, Claudius, Khanyaree, Ifrah, Melo, Aylin, Muckenhuber-Sternbauer, Susanna, Köhler, Janis, Öztürk, Ömer, Penzel, Nora, Popovic, David, Rangnick, Adrian, von Saldern, Sebastian, Sanfelici, Rachele, Spangemacher, Moritz, Tupac, Ana, Urquijo, Maria Fernanda, Weiske, Johanna, Wosgien, Antonia, Blume, Karsten, Gebhardt, Dominika, Kaiser, Nathalie, Milz, Ruth, Nikolaides, Alexandra, Seves, Mauro, Vent, Silke, Wassen, Martina, Andreou, Christina, Egloff, Laura, Harrisberger, Fabienne, Lenz, Claudia, Leanza, Letizia, Mackintosh, Amatya, Smieskova, Renata, Studerus, Erich, Walter, Anna, Widmayer, Sonja, Day, Chris, Iqbal, Mariam, Pelton, Mirabel, Mallikarjun, Pavan, Stainton, Alexandra, Lin, Ashleigh, Denissoff, Alexander, Ellilä, Anu, From, Tiina, Heinimaa, Markus, Ilonen, Tuula, Jalo, Päivi, Laurikainen, Heikki, Luutonen, Antti, Mäkela, Akseli, Paju, Janina, Pesonen, Henri, Säilä, Reetta-Liina, Toivonen, Anna, Turtonen, Otto, Solana, Ana Beatriz, Abraham, Manuela, Hehn, Nicolas, Schirmer, Timo, Altamura, Carlo, Belleri, Marika, Bottinelli, Francesca, Ferro, Adele, Re, Marta, Monzani, Emiliano, Sberna, Maurizio, D’Agostino, Armando, Del Fabro, Lorenzo, Perna, Giampaolo, Nobile, Maria, Alciati, Alessandra, Balestrieri, Matteo, Bonivento, Carolina, Cabras, Giuseppe, Fabbro, Franco, Garzitto, Marco, Piccin, Sara, Hoheisel, Linnea, Kambeitz-Ilankovic, Lana, Wenzel, Julian, Haas, Shalaila S., Antonucci, Linda A., Ruef, Anne, Schultze-Lutter, Frauke, Lichtenstein, Theresa, Rosen, Marlene, Dwyer, Dominic B., Salokangas, Raimo K.R., Lencer, Rebekka, Brambilla, Paolo, Borgwardt, Stephan, Wood, Stephen J., Upthegrove, Rachel, Bertolino, Alessandro, Ruhrmann, Stephan, Meisenzahl, Eva, Koutsouleris, Nikolaos, Fink, Gereon R., Daun, Silvia, and Kambeitz, Joseph

Published
2024
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12. Anhedonia as a Potential Transdiagnostic Phenotype With Immune-Related Changes in Recent-Onset Mental Health Disorders

Author

Lalousis, Paris Alexandros, Malaviya, Aanya, Khatibi, Ali, Saberi, Majid, Kambeitz-Ilankovic, Lana, Haas, Shalaila S., Wood, Stephen J., Barnes, Nicholas M., Rogers, Jack, Chisholm, Katharine, Bertolino, Alessandro, Borgwardt, Stefan, Brambilla, Paolo, Kambeitz, Joseph, Lencer, Rebekka, Pantelis, Christos, Ruhrmann, Stephan, Salokangas, Raimo K.R., Schultze-Lutter, Frauke, Schmidt, Andre, Meisenzahl, Eva, Dwyer, Dominic, Koutsouleris, Nikolaos, Upthegrove, Rachel, and Griffiths, Siân Lowri

Published
2024
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14. Brief Report: Specificity of Interpersonal Synchrony Deficits to Autism Spectrum Disorder and Its Potential for Digitally Assisted Diagnostics

Author

Koehler, Jana Christina, Georgescu, Alexandra Livia, Weiske, Johanna, Spangemacher, Moritz, Burghof, Lana, Falkai, Peter, Koutsouleris, Nikolaos, Tschacher, Wolfgang, Vogeley, Kai, and Falter-Wagner, Christine M.

Abstract

Reliably diagnosing autism spectrum disorders (ASD) in adulthood poses a challenge to clinicians due to the absence of specific diagnostic markers. This study investigated the potential of interpersonal synchrony (IPS), which has been found to be reduced in ASD, to augment the diagnostic process. IPS was objectively assessed in videos of diagnostic interviews in a representative referral population from two specialized autism outpatient clinics. In contrast to the current screening tools that could not reliably differentiate, we found a significant reduction of IPS in interactions with individuals later diagnosed with ASD (n = 16) as opposed to those not receiving a diagnosis (n = 23). While these findings need to be validated in larger samples, they nevertheless underline the potential of digitally-enhanced diagnostic processes for ASD.

Published
2022
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15. Psychosis brain subtypes validated in first-episode cohorts and related to illness remission: results from the PHENOM consortium

Author

Dwyer, Dominic B., Chand, Ganesh B., Pigoni, Alessandro, Khuntia, Adyasha, Wen, Junhao, Antoniades, Mathilde, Hwang, Gyujoon, Erus, Guray, Doshi, Jimit, Srinivasan, Dhivya, Varol, Erdem, Kahn, Rene S., Schnack, Hugo G., Meisenzahl, Eva, Wood, Stephen J., Zhuo, Chuanjun, Sotiras, Aristeidis, Shinohara, Russell T., Shou, Haochang, Fan, Yong, Schaulfelberger, Maristela, Rosa, Pedro, Lalousis, Paris A., Upthegrove, Rachel, Kaczkurkin, Antonia N., Moore, Tyler M., Nelson, Barnaby, Gur, Raquel E., Gur, Ruben C., Ritchie, Marylyn D., Satterthwaite, Theodore D., Murray, Robin M., Di Forti, Marta, Ciufolini, Simone, Zanetti, Marcus V., Wolf, Daniel H., Pantelis, Christos, Crespo-Facorro, Benedicto, Busatto, Geraldo F., Davatzikos, Christos, Koutsouleris, Nikolaos, and Dazzan, Paola

Published
2023
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17. A multivariate cognitive approach to predict social functioning in recent onset psychosis in response to computerized cognitive training

Author

Walter, Nina, Wenzel, Julian, Haas, Shalaila S., Squarcina, Letizia, Bonivento, Carolina, Ruef, Anne, Dwyer, Dominic, Lichtenstein, Theresa, Bastrük, Öznur, Stainton, Alexandra, Antonucci, Linda A., Brambilla, Paolo, Wood, Stephen J., Upthegrove, Rachel, Borgwardt, Stefan, Lencer, Rebekka, Meisenzahl, Eva, Salokangas, Raimo K.R., Pantelis, Christos, Bertolino, Alessandro, Koutsouleris, Nikolaos, Kambeitz, Joseph, and Kambeitz-Ilankovic, Lana

Published
2024
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18. Toward Generalizable and Transdiagnostic Tools for Psychosis Prediction: An Independent Validation and Improvement of the NAPLS-2 Risk Calculator in the Multisite PRONIA Cohort.

Author

Koutsouleris, Nikolaos, Worthington, Michelle, Dwyer, Dominic B, Kambeitz-Ilankovic, Lana, Sanfelici, Rachele, Fusar-Poli, Paolo, Rosen, Marlene, Ruhrmann, Stephan, Anticevic, Alan, Addington, Jean, Perkins, Diana O, Bearden, Carrie E, Cornblatt, Barbara A, Cadenhead, Kristin S, Mathalon, Daniel H, McGlashan, Thomas, Seidman, Larry, Tsuang, Ming, Walker, Elaine F, Woods, Scott W, Falkai, Peter, Lencer, Rebekka, Bertolino, Alessandro, Kambeitz, Joseph, Schultze-Lutter, Frauke, Meisenzahl, Eva, Salokangas, Raimo KR, Hietala, Jarmo, Brambilla, Paolo, Upthegrove, Rachel, Borgwardt, Stefan, Wood, Stephen, Gur, Raquel E, McGuire, Philip, and Cannon, Tyrone D

Subjects
Humans, Prognosis, Risk Factors, Longitudinal Studies, Psychotic Disorders, Prodromal Symptoms, Clinical high-risk states, First-episode depression, Machine learning, Psychosis prediction, Reciprocal external validation, Risk calculators, Prevention, Mental Health, Brain Disorders, Patient Safety, Mental health, Good Health and Well Being, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

BackgroundTransition to psychosis is among the most adverse outcomes of clinical high-risk (CHR) syndromes encompassing ultra-high risk (UHR) and basic symptom states. Clinical risk calculators may facilitate an early and individualized interception of psychosis, but their real-world implementation requires thorough validation across diverse risk populations, including young patients with depressive syndromes.MethodsWe validated the previously described NAPLS-2 (North American Prodrome Longitudinal Study 2) calculator in 334 patients (26 with transition to psychosis) with CHR or recent-onset depression (ROD) drawn from the multisite European PRONIA (Personalised Prognostic Tools for Early Psychosis Management) study. Patients were categorized into three risk enrichment levels, ranging from UHR, over CHR, to a broad-risk population comprising patients with CHR or ROD (CHR|ROD). We assessed how risk enrichment and different predictive algorithms influenced prognostic performance using reciprocal external validation.ResultsAfter calibration, the NAPLS-2 model predicted psychosis with a balanced accuracy (BAC) (sensitivity, specificity) of 68% (73%, 63%) in the PRONIA-UHR cohort, 67% (74%, 60%) in the CHR cohort, and 70% (73%, 66%) in patients with CHR|ROD. Multiple model derivation in PRONIA-CHR|ROD and validation in NAPLS-2-UHR patients confirmed that broader risk definitions produced more accurate risk calculators (CHR|ROD-based vs. UHR-based performance: 67% [68%, 66%] vs. 58% [61%, 56%]). Support vector machines were superior in CHR|ROD (BAC = 71%), while ridge logistic regression and support vector machines performed similarly in CHR (BAC = 67%) and UHR cohorts (BAC = 65%). Attenuated psychotic symptoms predicted psychosis across risk levels, while younger age and reduced processing speed became increasingly relevant for broader risk cohorts.ConclusionsClinical-neurocognitive machine learning models operating in young patients with affective and CHR syndromes facilitate a more precise and generalizable prediction of psychosis. Future studies should investigate their therapeutic utility in large-scale clinical trials.

Published
2021

19. Medical Image Harmonization Using Deep Learning Based Canonical Mapping: Toward Robust and Generalizable Learning in Imaging

Author

Bashyam, Vishnu M., Doshi, Jimit, Erus, Guray, Srinivasan, Dhivya, Abdulkadir, Ahmed, Habes, Mohamad, Fan, Yong, Masters, Colin L., Maruff, Paul, Zhuo, Chuanjun, Völzke, Henry, Johnson, Sterling C., Fripp, Jurgen, Koutsouleris, Nikolaos, Satterthwaite, Theodore D., Wolf, Daniel H., Gur, Raquel E., Gur, Ruben C., Morris, John C., Albert, Marilyn S., Grabe, Hans J., Resnick, Susan M., Bryan, R. Nick, Wolk, David A., Shou, Haochang, Nasrallah, Ilya M., and Davatzikos, Christos

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

Conventional and deep learning-based methods have shown great potential in the medical imaging domain, as means for deriving diagnostic, prognostic, and predictive biomarkers, and by contributing to precision medicine. However, these methods have yet to see widespread clinical adoption, in part due to limited generalization performance across various imaging devices, acquisition protocols, and patient populations. In this work, we propose a new paradigm in which data from a diverse range of acquisition conditions are "harmonized" to a common reference domain, where accurate model learning and prediction can take place. By learning an unsupervised image to image canonical mapping from diverse datasets to a reference domain using generative deep learning models, we aim to reduce confounding data variation while preserving semantic information, thereby rendering the learning task easier in the reference domain. We test this approach on two example problems, namely MRI-based brain age prediction and classification of schizophrenia, leveraging pooled cohorts of neuroimaging MRI data spanning 9 sites and 9701 subjects. Our results indicate a substantial improvement in these tasks in out-of-sample data, even when training is restricted to a single site.

Published
2020

20. Multivariate pattern analysis of brain structure predicts functional outcome after auditory-based cognitive training interventions.

Author

Kambeitz-Ilankovic, Lana, Vinogradov, Sophia, Wenzel, Julian, Fisher, Melissa, Haas, Shalaila S, Betz, Linda, Penzel, Nora, Nagarajan, Srikantan, Koutsouleris, Nikolaos, and Subramaniam, Karuna

Subjects
Schizophrenia, Brain Disorders, Behavioral and Social Science, Mental Health, Clinical Research, Neurosciences, Mental health
Abstract

Cognitive gains following cognitive training interventions are associated with improved functioning in people with schizophrenia (SCZ). However, considerable inter-individual variability is observed. Here, we evaluate the sensitivity of brain structural features to predict functional response to auditory-based cognitive training (ABCT) at a single-subject level. We employed whole-brain multivariate pattern analysis with support vector machine (SVM) modeling to identify gray matter (GM) patterns that predicted higher vs. lower functioning after 40 h of ABCT at the single-subject level in SCZ patients. The generalization capacity of the SVM model was evaluated by applying the original model through an out-of-sample cross-validation analysis to unseen SCZ patients from an independent validation sample who underwent 50 h of ABCT. The whole-brain GM volume-based pattern classification predicted higher vs. lower functioning at follow-up with a balanced accuracy (BAC) of 69.4% (sensitivity 72.2%, specificity 66.7%) as determined by nested cross-validation. The neuroanatomical model was generalizable to an independent cohort with a BAC of 62.1% (sensitivity 90.9%, specificity 33.3%). In particular, greater baseline GM volumes in regions within superior temporal gyrus, thalamus, anterior cingulate, and cerebellum predicted improved functioning at the single-subject level following ABCT in SCZ participants. The present findings provide a structural MRI fingerprint associated with preserved GM volumes at a single baseline timepoint, which predicted improved functioning following an ABCT intervention, and serve as a model for how to facilitate precision clinical therapies for SCZ based on imaging data, operating at the single-subject level.

Published
2021

21. Structural and Functional Brain Patterns Predict Formal Thought Disorder’s Severity and Its Persistence in Recent-Onset Psychosis: Results From the PRONIA Study

Author

Buciuman, Madalina-Octavia, Oeztuerk, Oemer Faruk, Popovic, David, Enrico, Paolo, Ruef, Anne, Bieler, Nadia, Sarisik, Elif, Weiske, Johanna, Dong, Mark Sen, Dwyer, Dominic B., Kambeitz-Ilankovic, Lana, Haas, Shalaila S., Stainton, Alexandra, Ruhrmann, Stephan, Chisholm, Katharine, Kambeitz, Joseph, Riecher-Rössler, Anita, Upthegrove, Rachel, Schultze-Lutter, Frauke, Salokangas, Raimo K.R., Hietala, Jarmo, Pantelis, Christos, Lencer, Rebekka, Meisenzahl, Eva, Wood, Stephen J., Brambilla, Paolo, Borgwardt, Stefan, Falkai, Peter, Antonucci, Linda A., Bertolino, Alessandro, Liddle, Peter, and Koutsouleris, Nikolaos

Published
2023
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22. Counterpoint. Early intervention for psychosis risk syndromes: Minimizing risk and maximizing benefit.

Author

Woods, Scott W, Bearden, Carrie E, Sabb, Fred W, Stone, William S, Torous, John, Cornblatt, Barbara A, Perkins, Diana O, Cadenhead, Kristin S, Addington, Jean, Powers, Albert R, Mathalon, Daniel H, Calkins, Monica E, Wolf, Daniel H, Corcoran, Cheryl M, Horton, Leslie E, Mittal, Vijay A, Schiffman, Jason, Ellman, Lauren M, Strauss, Gregory P, Mamah, Daniel, Choi, Jimmy, Pearlson, Godfrey D, Shah, Jai L, Fusar-Poli, Paolo, Arango, Celso, Perez, Jesus, Koutsouleris, Nikolaos, Wang, Jijun, Kwon, Jun Soo, Walsh, Barbara C, McGlashan, Thomas H, Hyman, Steven E, Gur, Raquel E, Cannon, Tyrone D, Kane, John M, and Anticevic, Alan

Subjects
Humans, Syndrome, Psychotic Disorders, Social Stigma, Autonomy, Beneficence, Biomarkers, Clinical high risk, Psychosis, Stigma, Clinical Research, Mental Health, Serious Mental Illness, Pediatric Research Initiative, Prevention, Good Health and Well Being, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

BackgroundMalhi et al. in this issue critique the clinical high risk (CHR) syndrome for psychosis.MethodResponse to points of critique.ResultsWe agree that inconsistency in CHR nomenclature should be minimized. We respectfully disagree on other points. In our view: a) individuals with CHR and their families need help, using existing interventions, even though we do not yet fully understand disease mechanisms; b) substantial progress has been made in identification of biomarkers; c) symptoms used to identify CHR are specific to psychotic illnesses; d) CHR diagnosis is not "extremely difficult"; e) the pattern of progression, although heterogenous, is discernible; f) "psychosis-like symptoms" are common but are not used to identify CHR; and g) on the point described as 'the real risk,' CHR diagnosis does not frequently cause harmful stigma.DiscussionMalhi et al.'s arguments do not fairly characterize progress in the CHR field nor efforts to minimize stigma. That said, much work remains in areas of consistent nomenclature, mechanisms of disease, dissecting heterogeneity, and biomarkers. With regard to what the authors term the "real risk" of stigma associated with a CHR "label," however, our view is that avoiding words like "risk" and "psychosis" reinforces the stigma that both they and we mean to oppose. Moreover, patients and their families benefit from being given a term that describes what is happening to them.

Published
2021

23. The impact of visual dysfunctions in recent-onset psychosis and clinical high-risk state for psychosis

Author

Schwarzer, Johanna M., Meyhoefer, Inga, Antonucci, Linda A., Kambeitz-Ilankovic, Lana, Surmann, Marian, Bienek, Olga, Romer, Georg, Dannlowski, Udo, Hahn, Tim, Korda, Alexandra, Dwyer, Dominic B., Ruef, Anne, Haas, Shalaila S., Rosen, Marlene, Lichtenstein, Theresa, Ruhrmann, Stephan, Kambeitz, Joseph, Salokangas, Raimo K. R., Pantelis, Christos, Schultze-Lutter, Frauke, Meisenzahl, Eva, Brambilla, Paolo, Bertolino, Alessandro, Borgwardt, Stefan, Upthegrove, Rachel, Koutsouleris, Nikolaos, and Lencer, Rebekka

Published
2022
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24. Acquisition and Use of 'Priors' in Autism: Typical in Deciding Where to Look, Atypical in Deciding What Is There

Author

Allenmark, Fredrik, Shi, Zhuanghua, Pistorius, Rasmus L., Theisinger, Laura A., Koutsouleris, Nikolaos, Falkai, Peter, Müller, Hermann J., and Falter-Wagner, Christine M.

Abstract

Individuals with Autism Spectrum Disorder (ASD) are thought to under-rely on prior knowledge in perceptual decision-making. This study examined whether this applies to decisions of attention allocation, of relevance for 'predictive-coding' accounts of ASD. In a visual search task, a salient but task-irrelevant distractor appeared with higher probability in one display half. Individuals with ASD learned to avoid 'attentional capture' by distractors in the probable region as effectively as control participants--indicating typical priors for deploying attention. However, capture by a 'surprising' distractor at an unlikely location led to greatly slowed identification of a subsequent target at that location--indicating that individuals with ASD attempt to control surprise (unexpected attentional capture) by over-regulating parameters in post-selective decision-making.

Published
2021
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25. Serum immune markers and transition to psychosis in individuals at clinical high risk

Author

Mondelli, Valeria, Blackman, Graham, Kempton, Matthew J., Pollak, Thomas A., Iyegbe, Conrad, Valmaggia, Lucia R., Amminger, Paul, Barrantes-Vidal, Neus, Bressan, Rodrigo, van der Gaag, Mark, de Haan, Lieuwe, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Riecher-Rössler, Anita, Rutten, Bart P.F., Sachs, Gabriele, Koutsouleris, Nikolaos, and McGuire, Philip

Published
2023
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26. Brief Report: Specificity of Interpersonal Synchrony Deficits to Autism Spectrum Disorder and Its Potential for Digitally Assisted Diagnostics

Author

Koehler, Jana Christina, Georgescu, Alexandra Livia, Weiske, Johanna, Spangemacher, Moritz, Burghof, Lana, Falkai, Peter, and Koutsouleris, Nikolaos

Subjects
Pervasive developmental disorders -- Diagnosis -- Risk factors, Social skills -- Evaluation, Health
Abstract

Reliably diagnosing autism spectrum disorders (ASD) in adulthood poses a challenge to clinicians due to the absence of specific diagnostic markers. This study investigated the potential of interpersonal synchrony (IPS), which has been found to be reduced in ASD, to augment the diagnostic process. IPS was objectively assessed in videos of diagnostic interviews in a representative referral population from two specialized autism outpatient clinics. In contrast to the current screening tools that could not reliably differentiate, we found a significant reduction of IPS in interactions with individuals later diagnosed with ASD (n = 16) as opposed to those not receiving a diagnosis (n = 23). While these findings need to be validated in larger samples, they nevertheless underline the potential of digitally-enhanced diagnostic processes for ASD., Author(s): Jana Christina Koehler [sup.1] , Alexandra Livia Georgescu [sup.5] , Johanna Weiske [sup.1] , Moritz Spangemacher [sup.1] , Lana Burghof [sup.2] , Peter Falkai [sup.1] , Nikolaos Koutsouleris [sup.1] [...]

Published
2022
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27. Use of Machine-Learning Algorithms Based on Text, Audio and Video Data in the Prediction of Anxiety and Post-Traumatic Stress in General and Clinical Populations: A Systematic Review

Author

Ciharova, Marketa, primary, Amarti, Khadicha, additional, van Breda, Ward, additional, Peng, Xianhua, additional, Lorente-Català, Rosa, additional, Funk, Burkhardt, additional, Hoogendoorn, Mark, additional, Koutsouleris, Nikolaos, additional, Fusar-Poli, Paolo, additional, Karyotaki, Eirini, additional, Cuijpers, Pim, additional, and Riper, Heleen, additional

Published
2024
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28. Neurocognitive dysfunction in adolescents with recent onset MDD - a cross-sectional comparative study

Author

Bienek, Olga, primary, Allott, Kelly, additional, Antonucci, Linda, additional, Bertolino, Alessandro, additional, Bonivento, Carolina, additional, Borgwardt, Stephan, additional, Brambilla, Paolo, additional, Chisholm, Katharine, additional, Dannlowski, Udo, additional, Haidl, Theresa K., additional, Kambeitz, Joseph, additional, Kambeitz-Ilankovic, Lana, additional, Koutsouleris, Nikolaos, additional, Lencer, Rebekka, additional, Griffiths, Siân Lowri, additional, Maggioni, Eleonora, additional, Meisenzahl, Eva, additional, Pantelis, Christos, additional, Rosen, Marlene, additional, Ruhrmann, Stephan, additional, Salokangas, Raimo K. R., additional, Stainton, Alexandra, additional, Upthegrove, Rachel, additional, Wenzel, Julian, additional, Wood, Stephen J., additional, Romer, Georg, additional, and Müller, Jörg Michael, additional

Published
2024
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29. Global and risk-group stratified well-being and mental health during the COVID-19 pandemic in adults: Results from the international COH-FIT Study

Author

Solmi, Marco, primary, Thompson, Trevor, additional, Estradé, Andrés, additional, Agorastos, Agorastos, additional, Radua, Joaquim, additional, Cortese, Samuele, additional, Dragioti, Elena, additional, Leisch, Friedrich, additional, Vancampfort, Davy, additional, Thygesen, Lau Caspar, additional, Aschauer, Harald, additional, Schlögelhofer, Monika, additional, Aschauer, Elena, additional, Schneeberger, Andres, additional, Huber, Christian G., additional, Hasler, Gregor, additional, Conus, Philippe, additional, Cuénod, Kim Q. Do, additional, von Känel, Roland, additional, Arrondo, Gonzalo, additional, Fusar-Poli, Paolo, additional, Gorwood, Philip, additional, Llorca, Pierre-Michel, additional, Krebs, Marie-Odile, additional, Scanferla, Elisabetta, additional, Kishimoto, Taishiro, additional, Rabbani, Golam, additional, Skonieczna-Żydecka, Karolina, additional, Brambilla, Paolo, additional, Favaro, Angela, additional, Takamiya, Akihiro, additional, Zoccante, Leonardo, additional, Colizzi, Marco, additional, Bourgin, Julie, additional, Kamiński, Karol, additional, Moghadasin, Maryam, additional, Seedat, Soraya, additional, Matthews, Evan, additional, Wells, John, additional, Vassilopoulou, Emilia, additional, Gadelha, Ary, additional, Su, Kuan-Pin, additional, Kwon, Jun Soo, additional, Kim, Minah, additional, Lee, Tae Young, additional, Papsuev, Oleg, additional, Manková, Denisa, additional, Boscutti, Andrea, additional, Gerunda, Cristiano, additional, Saccon, Diego, additional, Righi, Elena, additional, Monaco, Francesco, additional, Croatto, Giovanni, additional, Cereda, Guido, additional, Demurtas, Jacopo, additional, Brondino, Natascia, additional, Veronese, Nicola, additional, Enrico, Paolo, additional, Politi, Pierluigi, additional, Ciappolino, Valentina, additional, Pfennig, Andrea, additional, Bechdolf, Andreas, additional, Meyer-Lindenberg, Andreas, additional, Kahl, Kai G., additional, Domschke, Katharina, additional, Bauer, Michael, additional, Koutsouleris, Nikolaos, additional, Winter, Sibylle, additional, Borgwardt, Stefan, additional, Bitter, Istvan, additional, Balazs, Judit, additional, Czobor, Pál, additional, Unoka, Zsolt, additional, Mavridis, Dimitris, additional, Tsamakis, Konstantinos, additional, Bozikas, Vasilios P., additional, Tunvirachaisakul, Chavit, additional, Maes, Michael, additional, Rungnirundorn, Teerayuth, additional, Supasitthumrong, Thitiporn, additional, Haque, Ariful, additional, Brunoni, Andre R., additional, Costardi, Carlos Gustavo, additional, Schuch, Felipe Barreto, additional, Polanczyk, Guilherme, additional, Luiz, Jhoanne Merlyn, additional, Fonseca, Lais, additional, Aparicio, Luana V., additional, Valvassori, Samira S., additional, Nordentoft, Merete, additional, Vendsborg, Per, additional, Hoffmann, Sofie Have, additional, Sehli, Jihed, additional, Sartorius, Norman, additional, Heuss, Sabina, additional, Guinart, Daniel, additional, Hamilton, Jane, additional, Kane, John, additional, Rubio, Jose, additional, Sand, Michael, additional, Koyanagi, Ai, additional, Solanes, Aleix, additional, Andreu-Bernabeu, Alvaro, additional, Cáceres, Antonia San José, additional, Arango, Celso, additional, Díaz-Caneja, Covadonga M., additional, Hidalgo-Mazzei, Diego, additional, Vieta, Eduard, additional, Gonzalez-Peñas, Javier, additional, Fortea, Lydia, additional, Parellada, Mara, additional, Fullana, Miquel A., additional, Verdolini, Norma, additional, Andrlíková, Eva, additional, Janků, Karolina, additional, Millan, Mark J., additional, Honciuc, Mihaela, additional, Moniuszko-Malinowska, Anna, additional, Łoniewski, Igor, additional, Samochowiec, Jerzy, additional, Kiszkiel, Łukasz, additional, Marlicz, Maria, additional, Sowa, Paweł, additional, Marlicz, Wojciech, additional, Spies, Georgina, additional, Stubbs, Brendon, additional, Firth, Joseph, additional, Sullivan, Sarah, additional, Darcin, Asli Enez, additional, Aksu, Hatice, additional, Dilbaz, Nesrin, additional, Noyan, Onur, additional, Kitazawa, Momoko, additional, Kurokawa, Shunya, additional, Tazawa, Yuki, additional, Anselmi, Alejandro, additional, Cracco, Cecilia, additional, Machado, Ana Inés, additional, Estrade, Natalia, additional, De Leo, Diego, additional, Curtis, Jackie, additional, Berk, Michael, additional, Carvalho, Andre F., additional, Ward, Philip, additional, Teasdale, Scott, additional, Rosenbaum, Simon, additional, Marx, Wolfgang, additional, Horodnic, Adrian Vasile, additional, Oprea, Liviu, additional, Alexinschi, Ovidiu, additional, Ifteni, Petru, additional, Turliuc, Serban, additional, Ciuhodaru, Tudor, additional, Bolos, Alexandra, additional, Matei, Valentin, additional, Nieman, Dorien H., additional, Sommer, Iris, additional, van Os, Jim, additional, van Amelsvoort, Therese, additional, Sun, Ching-Fang, additional, Guu, Ta-wei, additional, Jiao, Can, additional, Zhang, Jieting, additional, Fan, Jialin, additional, Zou, Liye, additional, Yu, Xin, additional, Chi, Xinli, additional, de Timary, Philippe, additional, van Winkel, Ruud, additional, Ng, Bernardo, additional, Pena, Edilberto, additional, Arellano, Ramon, additional, Roman, Raquel, additional, Sanchez, Thelma, additional, Movina, Larisa, additional, Morgado, Pedro, additional, Brissos, Sofia, additional, Aizberg, Oleg, additional, Mosina, Anna, additional, Krinitski, Damir, additional, Mugisha, James, additional, Sadeghi-Bahmani, Dena, additional, Sheybani, Farshad, additional, Sadeghi, Masoud, additional, Hadi, Samira, additional, Brand, Serge, additional, Errazuriz, Antonia, additional, Crossley, Nicolas, additional, Ristic, Dragana Ignjatovic, additional, López-Jaramillo, Carlos, additional, Efthymiou, Dimitris, additional, Kuttichira, Praveenlal, additional, Kallivayalil, Roy Abraham, additional, Javed, Afzal, additional, Afridi, Muhammad Iqbal, additional, James, Bawo, additional, Seb-Akahomen, Omonefe Joy, additional, Fiedorowicz, Jess, additional, Daskalakis, Jeff, additional, Yatham, Lakshmi N., additional, Yang, Lin, additional, Okasha, Tarek, additional, Dahdouh, Aïcha, additional, Gerdle, Björn, additional, Tiihonen, Jari, additional, Shin, Jae Il, additional, Lee, Jinhee, additional, Mhalla, Ahmed, additional, Gaha, Lotfi, additional, Brahim, Takoua, additional, Altynbekov, Kuanysh, additional, Negay, Nikolay, additional, Nurmagambetova, Saltanat, additional, Jamei, Yasser Abu, additional, Weiser, Mark, additional, and Correll, Christoph U., additional

Published
2024
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30. 455. AI-Derived Neuroanatomical Subtypes of Schizophrenia and Their Expression During Disease Onset and in Unaffected Siblings

Author

Antoniades, Mathilde, primary, Yang, Zhijian, additional, Chand, Ganesh, additional, Schnack, Hugo, additional, Shinohara, Russell T., additional, Kaczkurkin, Antonia N., additional, Moore, Tyler M., additional, Gur, Raquel E., additional, Satterthwaite, Theodore D., additional, Di Forti, Marta, additional, Ciufolini, Simone, additional, Zanetti, Marcus V., additional, Crespo-Facorro, Benedicto, additional, Busatto, Geraldo F., additional, Wolf, Daniel H., additional, Dazzan, Paola, additional, Koutsouleris, Nikolaos, additional, and Davatzikos, Christos, additional

Published
2024
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31. The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study

Author

Oeztuerk, Oemer Faruk, Pigoni, Alessandro, Wenzel, Julian, Haas, Shalaila S., Popovic, David, Ruef, Anne, Dwyer, Dominic B., Kambeitz-Ilankovic, Lana, Ruhrmann, Stephan, Chisholm, Katharine, Lalousis, Paris, Griffiths, Sian Lowri, Lichtenstein, Theresa, Rosen, Marlene, Kambeitz, Joseph, Schultze-Lutter, Frauke, Liddle, Peter, Upthegrove, Rachel, Salokangas, Raimo K. R., Pantelis, Christos, Meisenzahl, Eva, Wood, Stephen J., Brambilla, Paolo, Borgwardt, Stefan, Falkai, Peter, Antonucci, Linda A., and Koutsouleris, Nikolaos

Published
2022
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35. Ethical considerations for precision psychiatry: A roadmap for research and clinical practice

Author

Fusar-Poli, Paolo, Manchia, Mirko, Koutsouleris, Nikolaos, Leslie, David, Woopen, Christiane, Calkins, Monica E., Dunn, Michael, Tourneau, Christophe Le, Mannikko, Miia, Mollema, Tineke, Oliver, Dominic, Rietschel, Marcella, Reininghaus, Eva Z., Squassina, Alessio, Valmaggia, Lucia, Kessing, Lars Vedel, Vieta, Eduard, Correll, Christoph U., Arango, Celso, and Andreassen, Ole A.

Published
2022
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36. Neurobiologically Based Stratification of Recent-Onset Depression and Psychosis: Identification of Two Distinct Transdiagnostic Phenotypes

Author

Lalousis, Paris Alexandros, Schmaal, Lianne, Wood, Stephen J., Reniers, Renate L.E.P., Barnes, Nicholas M., Chisholm, Katharine, Griffiths, Sian Lowri, Stainton, Alexandra, Wen, Junhao, Hwang, Gyujoon, Davatzikos, Christos, Wenzel, Julian, Kambeitz-Ilankovic, Lana, Andreou, Christina, Bonivento, Carolina, Dannlowski, Udo, Ferro, Adele, Lichtenstein, Theresa, Riecher-Rössler, Anita, Romer, Georg, Rosen, Marlene, Bertolino, Alessandro, Borgwardt, Stefan, Brambilla, Paolo, Kambeitz, Joseph, Lencer, Rebekka, Pantelis, Christos, Ruhrmann, Stephan, Salokangas, Raimo K.R., Schultze-Lutter, Frauke, Schmidt, André, Meisenzahl, Eva, Koutsouleris, Nikolaos, Dwyer, Dominic, and Upthegrove, Rachel

Published
2022
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37. Evidence of discontinuity between psychosis-risk and non-clinical samples in the neuroanatomical correlates of social function

Author

Haas, Shalaila S., Doucet, Gaelle E., Antoniades, Mathilde, Modabbernia, Amirhossein, Corcoran, Cheryl M., Kahn, René S., Kambeitz, Joseph, Kambeitz-Ilankovic, Lana, Borgwardt, Stefan, Brambilla, Paolo, Upthegrove, Rachel, Wood, Stephen J., Salokangas, Raimo K.R., Hietala, Jarmo, Meisenzahl, Eva, Koutsouleris, Nikolaos, and Frangou, Sophia

Published
2022
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40. Pattern of predictive features of continued cannabis use in patients with recent-onset psychosis and clinical high-risk for psychosis

Author

Penzel, Nora, Sanfelici, Rachele, Antonucci, Linda A., Betz, Linda T., Dwyer, Dominic, Ruef, Anne, Cho, Kang Ik K., Cumming, Paul, Pogarell, Oliver, Howes, Oliver, Falkai, Peter, Upthegrove, Rachel, Borgwardt, Stefan, Brambilla, Paolo, Lencer, Rebekka, Meisenzahl, Eva, Schultze-Lutter, Frauke, Rosen, Marlene, Lichtenstein, Theresa, Kambeitz-Ilankovic, Lana, Ruhrmann, Stephan, Salokangas, Raimo K. R., Pantelis, Christos, Wood, Stephen J., Quednow, Boris B., Pergola, Giulio, Bertolino, Alessandro, Koutsouleris, Nikolaos, and Kambeitz, Joseph

Published
2022
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42. Acquisition and Use of 'Priors' in Autism: Typical in Deciding Where to Look, Atypical in Deciding What Is There

Author

Allenmark, Fredrik, Shi, Zhuanghua, Pistorius, Rasmus L., Theisinger, Laura A., Koutsouleris, Nikolaos, Falkai, Peter, and Müller, Hermann J.

Subjects
Pervasive developmental disorders -- Diagnosis -- Development and progression, Attention -- Evaluation, Decision-making -- Evaluation, Health
Abstract

Individuals with Autism Spectrum Disorder (ASD) are thought to under-rely on prior knowledge in perceptual decision-making. This study examined whether this applies to decisions of attention allocation, of relevance for 'predictive-coding' accounts of ASD. In a visual search task, a salient but task-irrelevant distractor appeared with higher probability in one display half. Individuals with ASD learned to avoid 'attentional capture' by distractors in the probable region as effectively as control participants-indicating typical priors for deploying attention. However, capture by a 'surprising' distractor at an unlikely location led to greatly slowed identification of a subsequent target at that location-indicating that individuals with ASD attempt to control surprise (unexpected attentional capture) by over-regulating parameters in post-selective decision-making., Author(s): Fredrik Allenmark [sup.1] , Zhuanghua Shi [sup.1] , Rasmus L. Pistorius [sup.2] , Laura A. Theisinger [sup.2] , Nikolaos Koutsouleris [sup.2] , Peter Falkai [sup.2] , Hermann J. Müller [...]

Published
2021
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43. Distinct multimodal biological and functional profiles of symptom-based subgroups in recent-onset psychosis

Author

Koutsouleris, Nikolaos, primary, Buciuman, Madalina-Octavia, additional, Vetter, Clara Sophie, additional, Weyer, Clara Francesca Charlotte, additional, Zhutovsky, Paul, additional, Perdomo, Santiago Tovar, additional, Khuntia, Adyasha, additional, milaneschi, yuri, additional, Popovic, David, additional, Ruef, Anne, additional, Dwyer, Dominic, additional, Chisholm, Katharine, additional, Kambeitz, Lana, additional, Antonucci, Linda, additional, Ruhrmann, Stephan, additional, Kambeitz, Joseph, additional, Riecher-Rössler, Anita, additional, Upthegrove, Rachel, additional, Salokangas, Raimo, additional, Hietala, Jarmo, additional, Pantelis, Christos, additional, Lencer, Rebekka, additional, Meisenzahl, Eva, additional, Wood, Stephen, additional, Brambilla, Paolo, additional, Borgwardt, Stefan, additional, Bertolino, Alessandro, additional, and Falkai, Peter, additional

Published
2024
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44. Longitudinal evolution of the transdiagnostic prodrome to severe mental disorders: a dynamic temporal network analysis informed by natural language processing and electronic health records

Author

Arribas, Maite, primary, Barnby, Joseph M., additional, Patel, Rashmi, additional, McCutcheon, Robert A., additional, Kornblum, Daisy, additional, Shetty, Hitesh, additional, Krakowski, Kamil, additional, Stahl, Daniel, additional, Koutsouleris, Nikolaos, additional, McGuire, Philip, additional, Fusar-Poli, Paolo, additional, and Oliver, Dominic, additional

Published
2024
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45. Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis

Author

Wannan, Cassandra M J, primary, Nelson, Barnaby, additional, Addington, Jean, additional, Allott, Kelly, additional, Anticevic, Alan, additional, Arango, Celso, additional, Baker, Justin T, additional, Bearden, Carrie E, additional, Billah, Tashrif, additional, Bouix, Sylvain, additional, Broome, Matthew R, additional, Buccilli, Kate, additional, Cadenhead, Kristin S, additional, Calkins, Monica E, additional, Cannon, Tyrone D, additional, Cecci, Guillermo, additional, Chen, Eric Yu Hai, additional, Cho, Kang Ik K, additional, Choi, Jimmy, additional, Clark, Scott R, additional, Coleman, Michael J, additional, Conus, Philippe, additional, Corcoran, Cheryl M, additional, Cornblatt, Barbara A, additional, Diaz-Caneja, Covadonga M, additional, Dwyer, Dominic, additional, Ebdrup, Bjørn H, additional, Ellman, Lauren M, additional, Fusar-Poli, Paolo, additional, Galindo, Liliana, additional, Gaspar, Pablo A, additional, Gerber, Carla, additional, Glenthøj, Louise Birkedal, additional, Glynn, Robert, additional, Harms, Michael P, additional, Horton, Leslie E, additional, Kahn, René S, additional, Kambeitz, Joseph, additional, Kambeitz-Ilankovic, Lana, additional, Kane, John M, additional, Kapur, Tina, additional, Keshavan, Matcheri S, additional, Kim, Sung-Wan, additional, Koutsouleris, Nikolaos, additional, Kubicki, Marek, additional, Kwon, Jun Soo, additional, Langbein, Kerstin, additional, Lewandowski, Kathryn E, additional, Light, Gregory A, additional, Mamah, Daniel, additional, Marcy, Patricia J, additional, Mathalon, Daniel H, additional, McGorry, Patrick D, additional, Mittal, Vijay A, additional, Nordentoft, Merete, additional, Nunez, Angela, additional, Pasternak, Ofer, additional, Pearlson, Godfrey D, additional, Perez, Jesus, additional, Perkins, Diana O, additional, Powers, Albert R, additional, Roalf, David R, additional, Sabb, Fred W, additional, Schiffman, Jason, additional, Shah, Jai L, additional, Smesny, Stefan, additional, Spark, Jessica, additional, Stone, William S, additional, Strauss, Gregory P, additional, Tamayo, Zailyn, additional, Torous, John, additional, Upthegrove, Rachel, additional, Vangel, Mark, additional, Verma, Swapna, additional, Wang, Jijun, additional, Rossum, Inge Winter-van, additional, Wolf, Daniel H, additional, Wolff, Phillip, additional, Wood, Stephen J, additional, Yung, Alison R, additional, Agurto, Carla, additional, Alvarez-Jimenez, Mario, additional, Amminger, Paul, additional, Armando, Marco, additional, Asgari-Targhi, Ameneh, additional, Cahill, John, additional, Carrión, Ricardo E, additional, Castro, Eduardo, additional, Cetin-Karayumak, Suheyla, additional, Mallar Chakravarty, M, additional, Cho, Youngsun T, additional, Cotter, David, additional, D’Alfonso, Simon, additional, Ennis, Michaela, additional, Fadnavis, Shreyas, additional, Fonteneau, Clara, additional, Gao, Caroline, additional, Gupta, Tina, additional, Gur, Raquel E, additional, Gur, Ruben C, additional, Hamilton, Holly K, additional, Hoftman, Gil D, additional, Jacobs, Grace R, additional, Jarcho, Johanna, additional, Ji, Jie Lisa, additional, Kohler, Christian G, additional, Lalousis, Paris Alexandros, additional, Lavoie, Suzie, additional, Lepage, Martin, additional, Liebenthal, Einat, additional, Mervis, Josh, additional, Murty, Vishnu, additional, Nicholas, Spero C, additional, Ning, Lipeng, additional, Penzel, Nora, additional, Poldrack, Russell, additional, Polosecki, Pablo, additional, Pratt, Danielle N, additional, Rabin, Rachel, additional, Rahimi Eichi, Habiballah, additional, Rathi, Yogesh, additional, Reichenberg, Avraham, additional, Reinen, Jenna, additional, Rogers, Jack, additional, Ruiz-Yu, Bernalyn, additional, Scott, Isabelle, additional, Seitz-Holland, Johanna, additional, Srihari, Vinod H, additional, Srivastava, Agrima, additional, Thompson, Andrew, additional, Turetsky, Bruce I, additional, Walsh, Barbara C, additional, Whitford, Thomas, additional, Wigman, Johanna T W, additional, Yao, Beier, additional, Yuen, Hok Pan, additional, Ahmed, Uzair, additional, Byun, Andrew (Jin Soo), additional, Chung, Yoonho, additional, Do, Kim, additional, Hendricks, Larry, additional, Huynh, Kevin, additional, Jeffries, Clark, additional, Lane, Erlend, additional, Langholm, Carsten, additional, Lin, Eric, additional, Mantua, Valentina, additional, Santorelli, Gennarina, additional, Ruparel, Kosha, additional, Zoupou, Eirini, additional, Adasme, Tatiana, additional, Addamo, Lauren, additional, Adery, Laura, additional, Ali, Munaza, additional, Auther, Andrea, additional, Aversa, Samantha, additional, Baek, Seon-Hwa, additional, Bates, Kelly, additional, Bathery, Alyssa, additional, Bayer, Johanna M M, additional, Beedham, Rebecca, additional, Bilgrami, Zarina, additional, Birch, Sonia, additional, Bonoldi, Ilaria, additional, Borders, Owen, additional, Borgatti, Renato, additional, Brown, Lisa, additional, Bruna, Alejandro, additional, Carrington, Holly, additional, Castillo-Passi, Rolando I, additional, Chen, Justine, additional, Cheng, Nicholas, additional, Ching, Ann Ee, additional, Clifford, Chloe, additional, Colton, Beau-Luke, additional, Contreras, Pamela, additional, Corral, Sebastián, additional, Damiani, Stefano, additional, Done, Monica, additional, Estradé, Andrés, additional, Etuka, Brandon Asika, additional, Formica, Melanie, additional, Furlan, Rachel, additional, Geljic, Mia, additional, Germano, Carmela, additional, Getachew, Ruth, additional, Goncalves, Mathias, additional, Haidar, Anastasia, additional, Hartmann, Jessica, additional, Jo, Anna, additional, John, Omar, additional, Kerins, Sarah, additional, Kerr, Melissa, additional, Kesselring, Irena, additional, Kim, Honey, additional, Kim, Nicholas, additional, Kinney, Kyle, additional, Krcmar, Marija, additional, Kotler, Elana, additional, Lafanechere, Melanie, additional, Lee, Clarice, additional, Llerena, Joshua, additional, Markiewicz, Christopher, additional, Matnejl, Priya, additional, Maturana, Alejandro, additional, Mavambu, Aissata, additional, Mayol-Troncoso, Rocío, additional, McDonnell, Amelia, additional, McGowan, Alessia, additional, McLaughlin, Danielle, additional, McIlhenny, Rebecca, additional, McQueen, Brittany, additional, Mebrahtu, Yohannes, additional, Mensi, Martina, additional, Hui, Christy Lai Ming, additional, Suen, Yi Nam, additional, Wong, Stephanie Ming Yin, additional, Morrell, Neal, additional, Omar, Mariam, additional, Partridge, Alice, additional, Phassouliotis, Christina, additional, Pichiecchio, Anna, additional, Politi, Pierluigi, additional, Porter, Christian, additional, Provenzani, Umberto, additional, Prunier, Nicholas, additional, Raj, Jasmine, additional, Ray, Susan, additional, Rayner, Victoria, additional, Reyes, Manuel, additional, Reynolds, Kate, additional, Rush, Sage, additional, Salinas, Cesar, additional, Shetty, Jashmina, additional, Snowball, Callum, additional, Tod, Sophie, additional, Turra-Fariña, Gabriel, additional, Valle, Daniela, additional, Veale, Simone, additional, Whitson, Sarah, additional, Wickham, Alana, additional, Youn, Sarah, additional, Zamorano, Francisco, additional, Zavaglia, Elissa, additional, Zinberg, Jamie, additional, Woods, Scott W, additional, and Shenton, Martha E, additional

Published
2024
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47. Towards Precision Psychiatry for Youth: the PRE-EMPT Centre of Research Excellence Roadmap.

Author

Dwyer, Dominic, primary, Clark, Scott, additional, Amminger, G. Paul, additional, Byrne, Enda, additional, Davey, Christopher, additional, Gao, Caroline, additional, Hartmann, Simon, additional, Hartmann, Jessica, additional, Koutsouleris, Nikolaos, additional, Ye, Rochelle, additional, Nguyen, Josh, additional, Ja, Julie, additional, Scott, Isabelle, additional, Wannan, Cassandra, additional, Ching, Ann Ee, additional, Lin, Ashleigh, additional, Caave, Blake, additional, McGorry, Patrick, additional, Middeldorp, Christel, additional, Ronald, Angelica, additional, Schmaal, Lianne, additional, Thompson, Andy, additional, Wigman, J.T.W, additional, Wood, Stephen, additional, Yung, Alison, additional, and Nelson, Barnaby, additional

Published
2024
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49. Association between age of cannabis initiation and gray matter covariance networks in recent onset psychosis

Author

Penzel, Nora, Antonucci, Linda A., Betz, Linda T., Sanfelici, Rachele, Weiske, Johanna, Pogarell, Oliver, Cumming, Paul, Quednow, Boris B., Howes, Oliver, Falkai, Peter, Upthegrove, Rachel, Bertolino, Alessandro, Borgwardt, Stefan, Brambilla, Paolo, Lencer, Rebekka, Meisenzahl, Eva, Rosen, Marlene, Haidl, Theresa, Kambeitz-Ilankovic, Lana, Ruhrmann, Stephan, Salokangas, Raimo R. K., Pantelis, Christos, Wood, Stephen J., Koutsouleris, Nikolaos, and Kambeitz, Joseph

Published
2021
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50. Cognitive subtypes in recent onset psychosis: distinct neurobiological fingerprints?

Author

Wenzel, Julian, Haas, Shalaila S., Dwyer, Dominic B., Ruef, Anne, Oeztuerk, Oemer Faruk, Antonucci, Linda A., von Saldern, Sebastian, Bonivento, Carolina, Garzitto, Marco, Ferro, Adele, Paolini, Marco, Blautzik, Janusch, Borgwardt, Stefan, Brambilla, Paolo, Meisenzahl, Eva, Salokangas, Raimo K. R., Upthegrove, Rachel, Wood, Stephen J., Kambeitz, Joseph, Koutsouleris, Nikolaos, and Kambeitz-Ilankovic, Lana

Published
2021
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