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1,012 results on '"Koutsilieris, Michael"'

7. Proteomics in Psoriasis: Recent Advances.

Author

LEOTSAKOS, GEORGIOS, KATAFIGIOTIS, IOANNIS, LEOTSAKOS, IOANNIS, KOUSTA, FIORI, MOLYMPAKIS, ARISTEIDIS, PERIMENI, AIKATERINI, and KOUTSILIERIS, MICHAEL

Subjects
PSORIASIS treatment, PROTEOMICS, BLOOD plasma, CYTOKINES, DATA analysis
Abstract

Psoriasis continues to affect a large percentage of patients worldwide and strongly appears to be a systematic disease. Efforts are being made to understand its etiology, which have led to research extended to genomic analysis with a focus on the role of pro-inflammatory cytokines, which play a major role in the pathogenesis of the disease. Plasma proteomic analysis in various diseases has provided promising results for choosing the right treatment for psoriasis, suggesting that it could play a key role in the prevention, prognosis, and treatment of the disease by individualizing treatment choices based on the proteomic profile of each patient. In this review, we focus on existing data in the bibliography on proteomic analysis in psoriasis and relevant approaches to future targeted therapies. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Effect of a 36-Week Supervised Exercise Training Program on Physical and Cognitive Function in Older Patients With Dementia

Author

BARDOPOULOU, MARI S., primary, PATSAKI, IRINI, additional, CHONDRONIKOLA, CHRISTINA, additional, CHRYSSANTHOPOULOS, COSTAS, additional, CHEROUVEIM, EVGENIA D., additional, LAKONITI, KLAOUNTIA-OLYMPIA, additional, MARIDAKI, MARIA, additional, PAPAGEORGIOU, SOKRATIS G., additional, KOUTSILIERIS, MICHAEL, additional, and PHILIPPOU, ANASTASSIOS, additional

Published
2023
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14. What is the true place of a double stimulation and double oocyte retrieval in the same cycle for patients diagnosed with poor ovarian reserve? A systematic review including a meta-analytical approach

Author

Sfakianoudis, Konstantinos, Pantos, Konstantinos, Grigoriadis, Sokratis, Rapani, Anna, Maziotis, Evangelos, Tsioulou, Petroula, Giannelou, Polina, Kontogeorgi, Adamantia, Pantou, Agni, Vlahos, Nikolaos, Koutsilieris, Michael, and Simopoulou, Mara

Published
2020
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17. The Effects of a Short-Term Combined Exercise Program on Liver Steatosis Indices and the Lipidemic and Glycemic Profile in NAFLD Individuals: A Pilot Study

Author

Voudouris, Dimitrios, primary, Horianopoulou, Maria, additional, Apostolopoulou, Zoi, additional, Chryssanthopoulos, Costas, additional, Bardopoulou, Mari, additional, Maridaki, Maria, additional, Vassilakopoulos, Theodoros, additional, Koutsilieris, Michael, additional, and Philippou, Anastassios, additional

Published
2023
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21. Treating infertility: current affairs of cross-border reproductive care

Author

Simopoulou Mara, Sfakianoudis Konstantinos, Giannelou Polina, Pierouli Aikaterini, Rapani Anna, Maziotis Evangelos, Galatis Dionysios, Bakas Panagiotis, Vlahos Nikolaos, Pantos Konstantinos, and Koutsilieris Michael

Subjects
cbrc, risks, bioethics, art, Medicine
Abstract

Infertility patients are willing to travel abroad to receive the medical treatment of choice. A 2010 study reported that approximately 25,000 couples travel abroad annually seeking infertility treatment. The purpose of this review is to analyze the criteria and risks related to cross-border reproductive care (CBRC) from the perspective of the patients and explore the issues raised regarding the country of origin and the destination country. A computerized search was performed in PubMed employing respective keywords. The total number of published articles provided by our PubMed search was 1905. Criteria for selecting the destination country include: the economic status, legislation, quality of care and anonymity. Despite the fact that CBRC is becoming a familiar concept, it raises concerns for the practitioner and issues of a social and bioethical nature. Most of them stem from the fact that health care acquires a commercialization aspect. Medical tourism entails several risks, such as misconceptions regarding the destination country, and legal issues arising from differences in the judiciary systems. Larger studies evaluating all aspects of CBRC are imperative. Quality assurance, a consensus and a common platform of practice, along with a system of international governance based on human rights, are a necessity for CBRC patients.

Published
2019
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25. Effect of a 36-Week Supervised Exercise Training Program on Physical and Cognitive Function in Older Patients With Dementia.

Author

BARDOPOULOU, MARI S., PATSAKI, IRINI, CHONDRONIKOLA, CHRISTINA, CHRYSSANTHOPOULOS, COSTAS, CHEROUVEIM, EVGENIA D., LAKONITI, KLAOUNTIA-OLYMPIA, MARIDAKI, MARIA, PAPAGEORGIOU, SOKRATIS G., KOUTSILIERIS, MICHAEL, and PHILIPPOU, ANASTASSIOS

Subjects
EXERCISE, DEMENTIA, PHYSICAL activity, COGNITION disorders, OLDER patients
Abstract

Background/Aim: To investigate the effects of an exercise training program on physical and cognitive function in older patients with dementia. Patients and Methods: Thirtyeight patients with early-middle dementia (31 females and seven males), aged 80.6±6.9 years, residents in an Elderly Care Unit, either completed a 36-week structured exercise program (Intervention Group, IG; n=19), or received the usual medical care (Control Group, CG; n=19). Before and after the 36-week intervention, cognitive function was evaluated in both groups by Mini-Mental State Examination (MMSE) and depression by Geriatric Depression Scale (GDS); physical function was assessed using handgrip test, Timed Up to Go (TUG), Berg Balance Scale (BBS) and Chair-Stand Test (CST), and daily living functionality by Functional Rating Scale for Symptoms of Dementia (FRSSD). Results: As a result of exercise intervention, participants scored better in all functional and cognitive test assessments compared to the control group, as reflected by absolute and relative (%) differences in all metrics after the 36-week exercise program (p<0.001). Conclusion: A 36-week supervised exercise training program was found to result in significant improvements in physical and cognitive function of elderly patients in early to middle stages of dementia at an Elderly Care Unit. The promising results of this study shed more light on the adaptability of elderly patients with early and mild dementia to long-term exercise training and verified the feasibility of applying such programs in this clinical population. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Differential Expression of Insulin Growth Factor 1 (IGF-1) Isoforms in Different Types of Endometriosis: Preliminary Results of a Single-Center Study.

Author

Blontzos, Nikolaos, Mavrogianni, Despoina, Ntzeros, Konstantinos, Kathopoulis, Nikolaos, Moustogiannis, Athanasios, Philippou, Anastassios, Koutsilieris, Michael, and Protopapas, Athanasios

Subjects
ENDOMETRIOSIS, INSULIN, ENDOMETRIUM
Abstract

Endometriosis is a benign, estrogen-dependent gynecological condition with an uncertain exact pathogenetic mechanism. The aim of this study was to evaluate the potential differential expression of Insulin Growth Factor 1 (IGF-1) isoforms in deeply infiltrating endometriotic (DIE) lesions, in ovarian endometriomas, and in the eutopic endometrium of the same endometriosis patients and to compare their expression with that in the eutopic endometrium of women without endometriosis. A total of 39 patients were included: 28 with endometriosis, of whom 15 had endometriomas only, 7 had DIE nodules only, and 6 had both DIE and endometriomas, and 11 without endometriosis served as controls. We noticed a similar pattern of expression between IGF-1Ea and IGF-1Ec, which differed from that of the IGF-1Eb isoform, possibly implying differential biological actions of different isoforms in DIE subtypes. We observed a tendency of lower expression of IGF-1Ea and IGF-1Ec in endometriomas without DIE compared to endometriomas with concurrent DIE or in DIE nodules. In conclusion, differential expression of IGF-1 isoforms may indicate that DIE with its associated ovarian lesions and simple ovarian endometriosis should be considered as two forms of the disease developing under different molecular pathways. [ABSTRACT FROM AUTHOR]

Published
2024
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40. The role of exercise in cancer-related sarcopenia and sarcopenic obesity

Author

Papadopetraki, Argyro, Giannopoulos, Antonios, Maridaki, Maria, Zagouri, Flora, Droufakou, Stavroula, Koutsilieris, Michael, Philippou, Anastassios, Papadopetraki, Argyro, Giannopoulos, Antonios, Maridaki, Maria, Zagouri, Flora, Droufakou, Stavroula, Koutsilieris, Michael, and Philippou, Anastassios

Abstract

One of the most common adverse effects of cancer and its therapeutic strategies is sarcopenia, a condition which is characterised by excess muscle wasting and muscle strength loss due to the disrupted muscle homeostasis. Moreover, cancer-related sarcopenia may be combined with the increased deposition of fat mass, a syndrome called cancer-associated sarcopenic obesity. Both clinical conditions have significant clinical importance and can predict disease progression and survival. A growing body of evidence supports the claim that physical exercise is a safe and effective complementary therapy for oncology patients which can limit the cancer- and its treatment-related muscle catabolism and promote the maintenance of muscle mass. Moreover, even after the onset of sarcopenia, exercise interventions can counterbalance the muscle mass loss and improve the clinical appearance and quality of life of cancer patients. The aim of this narrative review was to describe the various pathophysiological mechanisms, such as protein synthesis, mitochondrial function, inflammatory response, and the hypothalamic–pituitary–adrenal axis, which are regulated by exercise and contribute to the management of sarcopenia and sarcopenic obesity. Moreover, myokines, factors produced by and released from exercising muscles, are being discussed as they appear to play an important role in mediating the beneficial effects of exercise against sarcopenia.

Published
2023
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43. Metabolic Responses of Pre-Exercise Carbohydrate Ingestion in Cycling and Running: 1401 Board #163 May 30 10:30 AM - 12:00 PM

Author

Alexandrou, Michaella, Kontrafouri, Chrysoula, Papafilippou, Damianos, Pountoukidou, Argyro, Tsolaki, Effraimia, Koloutsou, Maria Evangelia, Tzeravini, Evangelia, Zacharogiannis, Elias, Lambropoulos, Ioannis, Chryssanthopoulos, Costas, Kokkinos, Alexander, Maridaki, Maria, Koutsilieris, Michael, and Philippou, Anastassios

Published
2019
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