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349 results on '"Koushik, Anita"'

5. Identifiability and estimation under the test-negative design with population controls with the goal of identifying risk and preventive factors for SARS-CoV-2 infection

Author

Schnitzer, Mireille E., Harel, Daphna, Ho, Vikki, Koushik, Anita, and Merckx, Joanna

Subjects
Statistics - Methodology, Statistics - Applications
Abstract

Due to the rapidly evolving COVID-19 pandemic caused by the SARS-CoV-2 virus, quick public health investigations of the relationships between behaviours and infection risk are essential. Recently the test-negative design was proposed to recruit and survey participants who are symptomatic and being tested for SARS-CoV-2 infection with the goal of evaluating associations between the survey responses (including behaviours and environment) and testing positive on the test. It was also proposed to recruit additional controls who are part of the general population as a baseline comparison group in order to evaluate risk factors specific to SARS-CoV-2 infection. In this study, we consider an alternative design where we recruit among all individuals, symptomatic and asymptomatic, being tested for the virus in addition to population controls. We define a regression parameter related to a prospective risk factor analysis and investigate its identifiability under the two study designs. We review the difference between the prospective risk factor parameter and the parameter targeted in the typical test-negative design where only symptomatic and tested people are recruited. Using missing data directed acyclic graphs we provide conditions and required data collection under which identifiability of the prospective risk factor parameter is possible and compare the benefits and limitations of the alternative study designs and target parameters. We propose a novel inverse probability weighting estimator and demonstrate the performance of this estimator through simulation study.

Published
2020

8. Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study

Author

Brenner, Darren R, Fehringer, Gord, Zhang, Zuo-Feng, Lee, Yuan-Chin Amy, Meyers, Travis, Matsuo, Keitaro, Ito, Hidemi, Vineis, Paolo, Stucker, Isabelle, Boffetta, Paolo, Brennan, Paul, Christiani, David C, Diao, Nancy, Hong, Yun-Chul, Landi, Maria T, Morgenstern, Hal, Schwartz, Ann G, Rennert, Gad, Saliba, Walid, McLaughlin, John R, Harris, Curtis C, Orlow, Irene, Dios, Juan M Barros, Raviña, Alberto Ruano, Siemiatycki, Jack, Koushik, Anita, Cote, Michele, Lazarus, Philip, Fernandez-Tardon, Guillermo, Tardon, Adonina, Le Marchand, Loïc, Brenner, Hermann, Saum, Kai-Uwe, Duell, Eric J, Andrew, Angeline S, Consonni, Dario, Olsson, Ann, Hung, Rayjean J, and Straif, Kurt

Subjects
Biomedical and Clinical Sciences, Epidemiology, Health Sciences, Public Health, Oncology and Carcinogenesis, Cancer, Alcoholism, Alcohol Use and Health, Lung Cancer, Lung, Prevention, Substance Misuse, 2.2 Factors relating to the physical environment, Aetiology, Stroke, Good Health and Well Being, Adenocarcinoma, Aged, Alcohol Drinking, Alcoholic Beverages, Carcinoma, Squamous Cell, Case-Control Studies, Cohort Studies, Female, Humans, Lung Neoplasms, Male, Middle Aged, Odds Ratio, Risk Factors, Surveys and Questionnaires, Alcohol, Lung cancer, Pooled analysis, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundThere is inadequate evidence to determine whether there is an effect of alcohol consumption on lung cancer risk. We conducted a pooled analysis of data from the International Lung Cancer Consortium and the SYNERGY study to investigate this possible association by type of beverage with adjustment for other potential confounders.MethodsTwenty one case-control studies and one cohort study with alcohol-intake data obtained from questionnaires were included in this pooled analysis (19,149 cases and 362,340 controls). Adjusted odds ratios (OR) or hazard ratios (HR) with corresponding 95% confidence intervals (CI) were estimated for each measure of alcohol consumption. Effect estimates were combined using random or fixed-effects models where appropriate. Associations were examined for overall lung cancer and by histological type.ResultsWe observed an inverse association between overall risk of lung cancer and consumption of alcoholic beverages compared to non-drinkers, but the association was not monotonic. The lowest risk was observed for persons who consumed 10-19.9 g/day ethanol (OR vs. non-drinkers = 0.78; 95% CI: 0.67, 0.91), where 1 drink is approximately 12-15 g. This J-shaped association was most prominent for squamous cell carcinoma (SCC). The association with all lung cancer varied little by type of alcoholic beverage, but there were notable differences for SCC. We observed an association with beer intake (OR for ≥20 g/day vs nondrinker = 1.42; 95% CI: 1.06, 1.90).ConclusionsWhether the non-monotonic associations we observed or the positive association between beer drinking and squamous cell carcinoma reflect real effects await future analyses and insights about possible biological mechanisms.

Published
2019

9. Genetic data from nearly 63,000 women of European descent predicts DNA methylation biomarkers and epithelial ovarian cancer risk

Author

Yang, Yaohua, Wu, Lang, Shu, Xiang, Lu, Yingchang, Shu, Xiao-Ou, Cai, Qiuyin, Beeghly-Fadiel, Alicia, Li, Bingshan, Ye, Fei, Berchuck, Andrew, Anton-Culver, Hoda, Banerjee, Susana, Benitez, Javier, Bjørge, Line, Brenton, James D, Butzow, Ralf, Campbell, Ian G, Chang-Claude, Jenny, Chen, Kexin, Cook, Linda S, Cramer, Daniel W, deFazio, Anna, Dennis, Joe, Doherty, Jennifer A, Dörk, Thilo, Eccles, Diana M, Edwards, Digna Velez, Fasching, Peter A, Fortner, Renée T, Gayther, Simon A, Giles, Graham G, Glasspool, Rosalind M, Goode, Ellen L, Goodman, Marc T, Gronwald, Jacek, Harris, Holly R, Heitz, Florian, Hildebrandt, Michelle A, Høgdall, Estrid, Høgdall, Claus K, Huntsman, David G, Kar, Siddhartha P, Karlan, Beth Y, Kelemen, Linda E, Kiemeney, Lambertus A, Kjaer, Susanne K, Koushik, Anita, Lambrechts, Diether, Le, Nhu D, Levine, Douglas A, Massuger, Leon F, Matsuo, Keitaro, May, Taymaa, McNeish, Iain A, Menon, Usha, Modugno, Francesmary, Monteiro, Alvaro N, Moorman, Patricia G, Moysich, Kirsten B, Ness, Roberta B, Nevanlinna, Heli, Olsson, Håkan, Onland-Moret, N Charlotte, Park, Sue K, Paul, James, Pearce, Celeste L, Pejovic, Tanja, Phelan, Catherine M, Pike, Malcolm C, Ramus, Susan J, Riboli, Elio, Rodriguez-Antona, Cristina, Romieu, Isabelle, Sandler, Dale P, Schildkraut, Joellen M, Setiawan, Veronica W, Shan, Kang, Siddiqui, Nadeem, Sieh, Weiva, Stampfer, Meir J, Sutphen, Rebecca, Swerdlow, Anthony J, Szafron, Lukasz M, Teo, Soo Hwang, Tworoger, Shelley S, Tyrer, Jonathan P, Webb, Penelope M, Wentzensen, Nicolas, White, Emily, Willett, Walter C, Wolk, Alicja, Woo, Yin Ling, Wu, Anna H, Yan, Li, Yannoukakos, Drakoulis, Chenevix-Trench, Georgia, Sellers, Thomas A, Pharoah, Paul DP, Zheng, Wei, and Long, Jirong

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Genetics, Human Genome, Ovarian Cancer, Prevention, Clinical Research, Rare Diseases, Cancer, Aetiology, 2.1 Biological and endogenous factors, Biomarkers, Tumor, Carcinoma, Ovarian Epithelial, Cohort Studies, DNA Methylation, Female, Genetic Predisposition to Disease, Humans, Models, Genetic, Ovarian Neoplasms, Predictive Value of Tests, Risk, White People, Women's Health, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark of cancer. However, the role of DNA methylation in epithelial ovarian cancer (EOC) remains unclear. In this study, high-density genetic and DNA methylation data in white blood cells from the Framingham Heart Study (N = 1,595) were used to build genetic models to predict DNA methylation levels. These prediction models were then applied to the summary statistics of a genome-wide association study (GWAS) of ovarian cancer including 22,406 EOC cases and 40,941 controls to investigate genetically predicted DNA methylation levels in association with EOC risk. Among 62,938 CpG sites investigated, genetically predicted methylation levels at 89 CpG were significantly associated with EOC risk at a Bonferroni-corrected threshold of P < 7.94 × 10-7. Of them, 87 were located at GWAS-identified EOC susceptibility regions and two resided in a genomic region not previously reported to be associated with EOC risk. Integrative analyses of genetic, methylation, and gene expression data identified consistent directions of associations across 12 CpG, five genes, and EOC risk, suggesting that methylation at these 12 CpG may influence EOC risk by regulating expression of these five genes, namely MAPT, HOXB3, ABHD8, ARHGAP27, and SKAP1. We identified novel DNA methylation markers associated with EOC risk and propose that methylation at multiple CpG may affect EOC risk via regulation of gene expression. SIGNIFICANCE: Identification of novel DNA methylation markers associated with EOC risk suggests that methylation at multiple CpG may affect EOC risk through regulation of gene expression.

Published
2019

16. Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study

Author

Fehringer, Gordon, Brenner, Darren R, Zhang, Zuo‐Feng, Lee, Yuan‐Chin Amy, Matsuo, Keitaro, Ito, Hidemi, Lan, Qing, Vineis, Paolo, Johansson, Mattias, Overvad, Kim, Riboli, Elio, Trichopoulou, Antonia, Sacerdote, Carlotta, Stucker, Isabelle, Boffetta, Paolo, Brennan, Paul, Christiani, David C, Hong, Yun‐Chul, Landi, Maria Teresa, Morgenstern, Hal, Schwartz, Ann G, Wenzlaff, Angela S, Rennert, Gad, McLaughlin, John R, Harris, Curtis C, Olivo‐Marston, Susan, Orlow, Irene, Park, Bernard J, Zauderer, Marjorie, Dios, Juan M Barros, Raviña, Alberto Ruano, Siemiatycki, Jack, Koushik, Anita, Lazarus, Philip, Fernández‐Somoano, Ana, Tardon, Adonina, Le Marchand, Loic, Brenner, Hermann, Saum, Kai‐Uwe, Duell, Eric J, Andrew, Angeline S, Szeszenia‐Dabrowska, Neonila, Lissowska, Jolanta, Zaridze, David, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Foretova, Lenka, Janout, Vladimir, Bencko, Vladimir, Holcatova, Ivana, Pesatori, Angela Cecilia, Consonni, Dario, Olsson, Ann, Straif, Kurt, and Hung, Rayjean J

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Lung, Cancer, Substance Misuse, Tobacco, Alcoholism, Alcohol Use and Health, Tobacco Smoke and Health, Prevention, Lung Cancer, Cardiovascular, Stroke, Respiratory, Good Health and Well Being, Aged, Alcohol Drinking, Alcoholic Beverages, Asia, Case-Control Studies, Cohort Studies, Europe, Female, Humans, Lung Neoplasms, Male, Middle Aged, North America, Risk Factors, Smoking, alcohol, lung cancer, wine, beer, liquor, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

It is not clear whether alcohol consumption is associated with lung cancer risk. The relationship is likely confounded by smoking, complicating the interpretation of previous studies. We examined the association of alcohol consumption and lung cancer risk in a large pooled international sample, minimizing potential confounding of tobacco consumption by restricting analyses to never smokers. Our study included 22 case-control and cohort studies with a total of 2548 never-smoking lung cancer patients and 9362 never-smoking controls from North America, Europe and Asia within the International Lung Cancer Consortium (ILCCO) and SYNERGY Consortium. Alcohol consumption was categorized into amounts consumed (grams per day) and also modelled as a continuous variable using restricted cubic splines for potential non-linearity. Analyses by histologic sub-type were included. Associations by type of alcohol consumed (wine, beer and liquor) were also investigated. Alcohol consumption was inversely associated with lung cancer risk with evidence most strongly supporting lower risk for light and moderate drinkers relative to non-drinkers (>0-4.9 g per day: OR = 0.80, 95% CI = 0.70-0.90; 5-9.9 g per day: OR = 0.82, 95% CI = 0.69-0.99; 10-19.9 g per day: OR = 0.79, 95% CI = 0.65-0.96). Inverse associations were found for consumption of wine and liquor, but not beer. The results indicate that alcohol consumption is inversely associated with lung cancer risk, particularly among subjects with low to moderate consumption levels, and among wine and liquor drinkers, but not beer drinkers. Although our results should have no relevant bias from the confounding effect of smoking we cannot preclude that confounding by other factors contributed to the observed associations. Confounding in relation to the non-drinker reference category may be of particular importance.

Published
2017

19. Test negative design for vaccine effectiveness estimation in the context of the COVID-19 pandemic: A systematic methodology review

Author

Mésidor, Miceline, primary, Liu, Yan, additional, Talbot, Denis, additional, Skowronski, Danuta M., additional, De Serres, Gaston, additional, Merckx, Joanna, additional, Koushik, Anita, additional, Tadrous, Mina, additional, Carazo, Sara, additional, Jiang, Cong, additional, and Schnitzer, Mireille E., additional

Published
2023
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21. Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study

Author

Brenner, Darren R., Fehringer, Gord, Zhang, Zuo-Feng, Lee, Yuan-Chin Amy, Meyers, Travis, Matsuo, Keitaro, Ito, Hidemi, Vineis, Paolo, Stucker, Isabelle, Boffetta, Paolo, Brennan, Paul, Christiani, David. C., Diao, Nancy, Hong, Yun-Chul, Landi, Maria T., Morgenstern, Hal, Schwartz, Ann G., Rennert, Gad, Saliba, Walid, McLaughlin, John R., Harris, Curtis C., Orlow, Irene, Barros Dios, Juan M., Ruano Raviña, Alberto, Siemiatycki, Jack, Koushik, Anita, Cote, Michele, Lazarus, Philip, Fernandez-Tardon, Guillermo, Tardon, Adonina, Le Marchand, Loïc, Brenner, Hermann, Saum, Kai-Uwe, Duell, Eric J., Andrew, Angeline S., Consonni, Dario, Olsson, Ann, Hung, Rayjean J., and Straif, Kurt

Published
2019
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23. Hormonal and reproductive factors and the risk of ovarian cancer

Author

Koushik, Anita, Grundy, Anne, Abrahamowicz, Michal, Arseneau, Jocelyne, Gilbert, Lucy, Gotlieb, Walter H., Lacaille, Julie, Mes-Masson, Anne-Marie, Parent, Marie-Élise, Provencher, Diane M., Richardson, Lesley, and Siemiatycki, Jack

Published
2017

28. Intake of vitamins A, C, and E and folate and the risk of ovarian cancer in a pooled analysis of 10 cohort studies

Author

Koushik, Anita, Wang, Molin, Anderson, Kristin E., van den Brandt, Piet, Clendenen, Tess V., Eliassen, A. Heather, Freudenheim, Jo L., Genkinger, Jeanine M., Håkansson, Niclas, Marshall, James R., McCullough, Marjorie L., Miller, Anthony B., Robien, Kim, Rohan, Thomas E., Schairer, Catherine, Schouten, Leo J., Tworoger, Shelley S., Wang, Ying, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Smith-Warner, Stephanie A.

Published
2015

29. Alcohol intake and the risk of epithelial ovarian cancer.

Author

L'Espérance, Kevin, Grundy, Anne, Abrahamowicz, Michal, Arseneau, Jocelyne, Gilbert, Lucy, Gotlieb, Walter H., Provencher, Diane, and Koushik, Anita

Subjects
OVARIAN epithelial cancer, OLDER people, ALCOHOL, OVARIAN cancer, WHITE wines
Abstract

Purpose: To investigate the association between alcohol intake over the lifetime and the risk of overall, borderline, and invasive ovarian cancer. Methods: In a population-based case–control study of 495 cases and 902 controls, conducted in Montreal, Canada, average alcohol intake over the lifetime and during specific age periods were computed from a detailed assessment of the intake of beer, red wine, white wine and spirits. Multivariable logistic regression was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for the association between alcohol intake and ovarian cancer risk. Results: For each one drink/week increment in average alcohol intake over the lifetime, the adjusted OR (95% CI) was 1.06 (1.01–1.10) for ovarian cancer overall, 1.13 (1.06–1.20) for borderline ovarian cancers and 1.02 (0.97–1.08) for invasive ovarian cancers. This pattern of association was similarly observed for alcohol intake in early (15– < 25 years), mid (25– < 40 years) and late adulthood (≥ 40 years), as well as for the intake of specific alcohol beverages over the lifetime. Conclusions: Our results support the hypothesis that a higher alcohol intake modestly increases the risk of overall ovarian cancer, and more specifically, borderline tumours. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Predicted 25-hydroxyvitamin D over the adult lifetime and the risk of ovarian cancer.

Author

Ritonja, Jennifer A, Danieli, Coraline, Pana, Magnoudewa Priscille, Palmer, Michael J, L'Espérance, Kevin, Ho, Vikki, Abrahamowicz, Michal, and Koushik, Anita

Subjects
RISK assessment, SUNSHINE, RESEARCH funding, OVARIAN tumors, LOGISTIC regression analysis, TUMOR markers, DESCRIPTIVE statistics, ODDS ratio, CASE-control method, OVARIAN epithelial cancer, CONFIDENCE intervals, VITAMIN D, DIET, DISEASE risk factors, ADULTS
Abstract

The evidence from previous studies of serum 25-hydroxyvitamin D (25(OH)D) and ovarian cancer risk is not conclusive. However, the 25(OH)D levels were generally only measured in late adulthood, which may not capture the etiologically relevant exposure periods. We investigated predicted 25(OH)D over the adult lifetime in relation to ovarian cancer risk in a population-based case-control study conducted from 2011 to 2016 in Montreal, Canada (n = 490 cases and 896 controls). Predicted 25(OH)D was computed using previously validated regression models. Unconditional multivariable logistic regression models were used to estimate adjusted odds ratios (aORs) and 95% CIs for average predicted 25(OH)D over the adult lifetime and ovarian cancer risk. In addition, the relative importance of different periods of past 25(OH)D exposure was explored using a weighted cumulative exposure (WCE) model. For each 20-nmol/L increase in average predicted 25(OH)D over the adult lifetime, the aOR (95% CI) was 0.73 (0.55-0.96). In WCE analyses, the inverse association was strongest for exposures 5 to 20 years and 35 to 55 years prior to diagnosis, with aORs (95% CIs) of 0.82 (0.69-0.94) and 0.79 (0.66-1.02), respectively, for each 20-nmol/L increase in predicted 25(OH)D. These results support an inverse association between 25(OH)D levels in adulthood and ovarian cancer risk. This article is part of a Special Collection on Gynecological Cancers. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Meat consumption and cancer risk

Author

Genkinger, Jeanine M. and Koushik, Anita

Abstract

The large international variation in incidence rates of cancer, together with findings from migrant studies, suggest that environmental factors such as diet are associated with cancer risk. The intake of [...]

Published
2007

47. Intake of Fruits and Vegetables and Risk of Pancreatic Cancer in a Pooled Analysis of 14 Cohort Studies

Author

Koushik, Anita, Spiegelman, Donna, Albanes, Demetrius, Anderson, Kristin E., Bernstein, Leslie, van den Brandt, Piet A., Bergkvist, Leif, English, Dallas R., Freudenheim, Jo L., Fuchs, Charles S., Genkinger, Jeanine M., Giles, Graham G., Goldbohm, R. Alexandra, Horn-Ross, Pamela L., Männistö, Satu, McCullough, Marjorie L., Millen, Amy E., Miller, Anthony B., Robien, Kim, Rohan, Thomas E., Schatzkin, Arthur, Shikany, James M., Stolzenberg-Solomon, Rachael Z., Willett, Walter C., Wolk, Alicja, Ziegler, Regina G., and Smith-Warner, Stephanie A.

Published
2012
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