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21 results on '"Koury, Luisa C."'

1. STMN1 is highly expressed and contributes to clonogenicity in acute promyelocytic leukemia cells

Author

Vicari, Hugo Passos, Coelho-Silva, Juan Luiz, Pereira-Martins, Diego A., Lucena-Araujo, Antônio Roberto, Lima, Keli, Lipreri da Silva, Jean Carlos, Scheucher, Priscila Santos, Koury, Luisa C., de Melo, Raul A., Bittencourt, Rosane, Pagnano, Katia, Nunes, Elenaide, Fagundes, Evandro M., Kerbauy, Fabio, de Figueiredo-Pontes, Lorena Lobo, Costa-Lotufo, Leticia Veras, Rego, Eduardo Magalhães, Traina, Fabiola, and Machado-Neto, João Agostinho

Published
2022
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2. Combining gene mutation with gene expression analysis improves outcome prediction in acute promyelocytic leukemia

Author

Lucena-Araujo, Antonio R., Coelho-Silva, Juan L., Pereira-Martins, Diego A., Silveira, Douglas R., Koury, Luisa C., Melo, Raul A.M., Bittencourt, Rosane, Pagnano, Katia, Pasquini, Ricardo, Nunes, Elenaide C., Fagundes, Evandro M., Gloria, Ana B., Kerbauy, Fábio, de Lourdes Chauffaille, Maria, Bendit, Israel, Rocha, Vanderson, Keating, Armand, Tallman, Martin S., Ribeiro, Raul C., Dillon, Richard, Ganser, Arnold, Löwenberg, Bob, Valk, P.J.M., Lo-Coco, Francesco, Sanz, Miguel A., Berliner, Nancy, and Rego, Eduardo M.

Published
2019
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3. NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia

Author

Thomé, Carolina Hassibe, Ferreira, Germano Aguiar, Pereira-Martins, Diego Antonio, dos Santos, Guilherme Augusto, Ortiz, César Alexander, de Souza, Lucas Eduardo Botelho, Sobral, Lays Martins, Silva, Cleide Lúcia Araújo, Scheucher, Priscila Santos, Gil, Cristiane Damas, Leopoldino, Andréia Machado, Silveira, Douglas R. A., Coelho-Silva, Juan L., Traina, Fabíola, Koury, Luisa C., Melo, Raul A. M., Bittencourt, Rosane, Pagnano, Katia, Pasquini, Ricardo, Nunes, Elenaide C., Fagundes, Evandro M., Gloria, Ana Beatriz F., Kerbauy, Fábio Rodrigues, Chauffaille, Maria de Lourdes, Keating, Armand, Tallman, Martin S., Ribeiro, Raul C., Dillon, Richard, Ganser, Arnold, Löwenberg, Bob, Valk, Peter, Lo-Coco, Francesco, Sanz, Miguel A., Berliner, Nancy, Faça, Vitor Marcel, and Rego, Eduardo M.

Published
2020
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4. Clinical significance of mitochondrial DNA content in acute promyelocytic leukaemia

Author

Pereira‐Martins, Diego A., primary, Coelho‐Silva, Juan L., additional, Weinhäuser, Isabel, additional, Franca‐Neto, Pedro L., additional, Silveira, Douglas R., additional, Ortiz, César, additional, Moreira‐Aguiar, Amanda, additional, Lima, Marinus M., additional, Koury, Luisa C., additional, de Melo, Raul A., additional, Glória, Ana B., additional, Fagundes, Evandro M., additional, Lino, Bruno K., additional, Pagnano, Katia, additional, Bittencourt, Rosane, additional, Nunes, Elenaide, additional, Traina, Fabiola, additional, Figueiredo‐Pontes, Lorena, additional, Keating, Armand, additional, Tallman, Martin S., additional, Ribeiro, Raul C., additional, Dilon, Richard, additional, Ganser, Arnold, additional, Sanz, Miguel A., additional, Berliner, Nancy, additional, Valk, Peter, additional, Löwenberg, Bob, additional, Ottone, Tiziana, additional, Noguera, Nelida I., additional, Voso, Maria T., additional, Paoloni, Francesca, additional, Fazi, Paola, additional, Ammatuna, Emanuele, additional, Huls, Gerwin, additional, Schuringa, Jan Jacob, additional, Rego, Eduardo M., additional, and Lucena‐Araujo, Antonio R., additional

Published
2022
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5. STMN1 is highly expressed and contributes to clonogenicity in acute promyelocytic leukemia cells

Author

Vicari, Hugo Passos, primary, Coelho-Silva, Juan Luiz, additional, Pereira-Martins, Diego A., additional, Lucena-Araujo, Antônio Roberto, additional, Lima, Keli, additional, Lipreri da Silva, Jean Carlos, additional, Scheucher, Priscila Santos, additional, Koury, Luisa C., additional, de Melo, Raul A., additional, Bittencourt, Rosane, additional, Pagnano, Katia, additional, Nunes, Elenaide, additional, Fagundes, Evandro M., additional, Kerbauy, Fabio, additional, de Figueiredo-Pontes, Lorena Lobo, additional, Costa-Lotufo, Leticia Veras, additional, Rego, Eduardo Magalhães, additional, Traina, Fabiola, additional, and Machado-Neto, João Agostinho, additional

Published
2021
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6. Clinical Significance of Mitochondrial DNA Content in Acute Promyelocytic Leukemia

Author

Lucena-Araujo, Antonio R., primary, Pereira-Martins, Diego A, additional, Coelho-Silva, Juan L, additional, Weinhäuser, Isabel, additional, Franca-Neto, Pedro Luis, additional, Silveira, Douglas RA, additional, Lima, Marinus M, additional, Schuringa, Jan Jacob, additional, Koury, Luisa C, additional, Melo, Raul Antônio Morais, additional, Bittencourt, Rosane, additional, Pagnano, Katia B, additional, Nunes, Elenaide C., additional, Fagundes, Evandro Maranhão, additional, Kerbauy, Fabio R., additional, Figueredo-Pontes, Lorena, additional, and Rego, Eduardo M, additional

Published
2021
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7. Clinical significance of mitochondrial DNA content in acute promyelocytic leukaemia.

Author

Pereira‐Martins, Diego A., Coelho‐Silva, Juan L., Weinhäuser, Isabel, Franca‐Neto, Pedro L., Silveira, Douglas R., Ortiz, César, Moreira‐Aguiar, Amanda, Lima, Marinus M., Koury, Luisa C., de Melo, Raul A., Glória, Ana B., Fagundes, Evandro M., Lino, Bruno K., Pagnano, Katia, Bittencourt, Rosane, Nunes, Elenaide, Traina, Fabiola, Figueiredo‐Pontes, Lorena, Keating, Armand, and Tallman, Martin S.

Subjects
ACUTE promyelocytic leukemia, MITOCHONDRIAL DNA, PROPORTIONAL hazards models
Abstract

Summary: Although a growing body of evidence demonstrates that altered mtDNA content (mtDNAc) has clinical implications in several types of solid tumours, its prognostic relevance in acute promyelocytic leukaemia (APL) patients remains largely unknown. Here, we show that patients with higher‐than‐normal mtDNAc had better outcomes regardless of tumour burden. These results were more evident in patients with low‐risk of relapse. The multivariate Cox proportional hazard model demonstrated that high mtDNAc was independently associated with a decreased cumulative incidence of relapse. Altogether, our data highlights the possible role of mitochondrial metabolism in APL patients treated with ATRA. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Reduced SLIT2 is Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in Acute Promyelocytic Leukemia

Author

Weinhäuser, Isabel, primary, Pereira-Martins, Diego A., additional, Ortiz, Cesar, additional, Silveira, Douglas R., additional, Simões, Luíse A. A., additional, Bianco, Thiago M., additional, Araujo, Cleide L., additional, Koury, Luisa C., additional, Melo, Raul A. M., additional, Bittencourt, Rosane I., additional, Pagnano, Katia, additional, Pasquini, Ricardo, additional, Nunes, Elenaide C., additional, Fagundes, Evandro M., additional, Gloria, Ana B., additional, Kerbauy, Fábio, additional, Chauffaille, Maria de Lourdes, additional, Keating, Armand, additional, Tallman, Martin S., additional, Ribeiro, Raul C., additional, Dillon, Richard, additional, Ganser, Arnold, additional, Löwenberg, Bob, additional, Valk, Peter, additional, Lo-Coco, Francesco, additional, Sanz, Miguel A., additional, Berliner, Nancy, additional, Ammatuna, Emanuele, additional, Lucena-Araujo, Antonio R., additional, Schuringa, Jan Jacob, additional, and Rego, Eduardo M., additional

Published
2020
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9. Arsenic Trioxide Abrogate MN1 Mediated RA-Resistance in Acute Promyelocytic Leukemia

Author

Pereira-Martins, Diego A, primary, Coelho-Silva, Juan L, additional, Weinhäuser, Isabel, additional, Koury, Luisa C A, additional, Melo, Raul Antônio Morais, additional, Bittencourt, Rosane, additional, Pagnano, Katia B, additional, Pasquini, Ricardo, additional, Nunes, Elenaide C., additional, Fagundes, Evandro Maranhão, additional, Gloria, Ana Beatriz F., additional, Kerbauy, Fabio R., additional, Keating, Armand, additional, Tallman, Martin S., additional, Ribeiro, Raul, additional, Dillon, Richard, additional, Ganser, Arnold, additional, Heuser, Michael, additional, Löwenberg, Bob, additional, Valk, Peter, additional, Sanz, Miguel A., additional, Berliner, Nancy, additional, Lucena-Araujo, Antonio R., additional, and Rego, Eduardo M, additional

Published
2019
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10. Clinical and Functional Studies Reveal That TP73 Isoforms Levels Are Associated with Prognosis and RA-Resistance in Acute Promyelocytic Leukemia

Author

Ortiz Rojas, César Alexander, primary, Pereira-Martins, Diego A, additional, Weinhäuser, Isabel, additional, Almeida, Luciana Yamamoto, additional, Bianco, Thiago Mantello, additional, Figueiredo-Pontes, Lorena Lobo, additional, Koury, Luisa C A, additional, Melo, Raul Antônio Morais, additional, Bittencourt, Rosane, additional, Pagnano, Katia B, additional, Pasquini, Ricardo, additional, Nunes, Elenaide C., additional, Fagundes, Evandro Maranhão, additional, Gloria, Ana Beatriz F., additional, Kerbauy, Fabio R., additional, Keating, Armand, additional, Tallman, Martin S., additional, Ribeiro, Raul, additional, Dillon, Richard, additional, Ganser, Arnold, additional, Löwenberg, Bob, additional, Valk, Peter, additional, Sanz, Miguel A., additional, Berliner, Nancy, additional, and Rego, Eduardo M, additional

Published
2019
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11. Slit-Robo Pathway Is Clinically Relevant and May Represent a Potential Target in Acute Promyelocytic Leukemia

Author

Weinhäuser, Isabel, primary, Pereira-Martins, Diego Antonio, additional, Ortiz, Cesar, additional, Schiavinato, Josiane Lilian, additional, Bonaldo, Camila, additional, Koury, Luisa C, additional, De Deus Wagatsuma, Virginia Mara, additional, Melo, Raul Antônio Morais, additional, Bittencourt, Rosane, additional, Pagnano, Katia B, additional, Fagundes, Evandro Maranhão, additional, Gloria, Ana Beatriz F., additional, Kerbauy, Fabio R., additional, Chauffaille, Maria de Lourdes, additional, Pasquini, Ricardo, additional, Tallman, Martin S., additional, Ribeiro, Raul, additional, Dillon, Richard, additional, Keating, Armand, additional, Ganser, Arnold, additional, Lowenberg, Bob, additional, Valk, Peter, additional, Lo-Coco, Francesco, additional, Sanz, Miguel A., additional, Berliner, Nancy, additional, Lucena-Araujo, Antonio R., additional, and Rego, Eduardo Magalhães, additional

Published
2018
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12. Metformintreatment Overcomes ATRA-Resistance in Acute Promyelocytic Leukemia and Increases FOXO3A Expression

Author

Pereira-Martins, Diego Antonio, primary, Ortiz, Cesar, additional, Franca-Neto, Pedro Luis, additional, Weinhäuser, Isabel, additional, Schiavinato, Josiane Lilian, additional, Palma, Patrícia Vianna Bonini, additional, Bonaldo, Camila, additional, Koury, Luisa C A, additional, Do Nascimento, Mariane Cristina, additional, Melo, Raul Antônio Morais, additional, Bittencourt, Rosane, additional, Pagnano, Katia B B, additional, Pasquini, Ricardo, additional, Fagundes, Evandro Maranhão, additional, Gloria, Ana Beatriz F., additional, Kerbauy, Fabio R., additional, Chauffaille, Maria de Lourdes, additional, Keating, Armand, additional, Tallman, Martin S., additional, Ribeiro, Raul, additional, Dillon, Richard, additional, Ganser, Arnold, additional, Lowenberg, Bob, additional, Valk, Peter, additional, Lo-Coco, Francesco, additional, Sanz, Miguel A., additional, Berliner, Nancy, additional, Lucena-Araujo, Antonio R., additional, and Rego, Eduardo Magalhães, additional

Published
2018
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13. Abstract A39: Nuclear SET domain (NSD) protein lysine methyltransferases (KMT) are higher expressed in acute myeloid leukemia

Author

Wagatsuma, Virginia Mara de Deus, primary, Koury, Luisa C. A., additional, Sánchez, Silvia Helena, additional, Figueiredo-Pontes, Lorena Lobo, additional, Silva, Fernanda Borges da, additional, Dore, Adriana Ines, additional, Lima, Ana Silvia Gouvea de, additional, Lucena-Araujo, Antonio Roberto, additional, Traina, Fabiola, additional, Saldanha-Araujo, Felipe, additional, Pittella, Fabio, additional, and Rego, Eduardo Magalhães, additional

Published
2018
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14. Clinical impact of BAALC expression in high-risk acute promyelocytic leukemia

Author

Lucena-Araujo, Antonio R., primary, Pereira-Martins, Diego A., additional, Koury, Luisa C., additional, Franca-Neto, Pedro L., additional, Coelho-Silva, Juan L., additional, de Deus Wagatsuma, Virginia M., additional, Melo, Raul A. M., additional, Bittencourt, Rosane, additional, Pagnano, Katia, additional, Pasquini, Ricardo, additional, Chiattone, Carlos S., additional, Fagundes, Evandro M., additional, Chauffaille, Maria de Lourdes, additional, Schrier, Stanley L., additional, Tallman, Martin S., additional, Ribeiro, Raul C., additional, Grimwade, David, additional, Ganser, Arnold, additional, Löwenberg, Bob, additional, Lo-Coco, Francesco, additional, Sanz, Miguel A., additional, Berliner, Nancy, additional, and Rego, Eduardo M., additional

Published
2017
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15. Nuclear SET Domain (NSD) Protein Lysine Methyltransferases (KMT) Family Members Expression in Acute Myeloid Leukemia

Author

De Deus Wagatsuma, Virginia Mara, primary, Koury, Luisa C A, additional, Sánchez, Silvia Elena, additional, Pontes, Lorena Lobo Figueiredo, additional, da Silva, Fernanda Borges, additional, Dore, Adriana Ines, additional, Gouvêa de Lima, Ana Silvia, additional, Lucena-Araujo, Antonio R., additional, Almeida, Luciana Yamamoto, additional, Traina, Fabiola, additional, Saldanha-Araújo, Felipe, additional, Pittella-Silva, Fabio, additional, and Rego, Eduardo Magalhães, additional

Published
2016
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16. The Use of Cyclosporine in Association with Chemotherapy As Induction Treatment in Patients with Acute Myeloid Leukemia (AML) and High Rhodamine Efflux at Diagnosis Results in Higher Complete Hematological Remission Rates, but Does Not Prolong Overall Survival

Author

Koury, Luisa C A, primary, Figueiredo-Pontes, Lorena Lobo, additional, Simoes, Belinda Pinto, additional, Oliveira, Luciana C O, additional, Dalmazzo, Leandro F F, additional, Pintão, Maria Carolina Tostes, additional, Garcia, Aglair B, additional, Falcão, Roberto Passetto, additional, and Rego, Eduardo Magalhães, additional

Published
2015
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17. Combining Gene Mutation with Gene Expression Data Improves Outcomes Prediction in Acute Promyelocytic Leukemia

Author

Lucena-Araujo, Antonio R., Pereira-Martins, Diego A, Koury, Luisa C A, Coelho-Silva, Juan Luiz, Melo, Raul Antônio Morais, Bittencourt, Rosane, Pagnano, Katia B, Pasquini, Ricardo, Chiattone, Carlos, Fagundes, Evandro Maranhão, Chauffaille, Maria de Lourdes, Schrier, Stanley L., Tallman, Martin S., Ribeiro, Raul C., Grimwade, David, Ganser, Arnold, Lowenberg, Bob, Lo Coco, Francesco, Sanz, Miguel A., Berliner, Nancy, and Rego, Eduardo Magalhães

Published
2017
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18. Association between Nuclear SET Domain (NSD) Protein Lysine Methyltransferases (KMT) Expression and Poor Prognosis in Acute Promyelocytic Leukemia (APL) Patients Treated with ATRA and Anthracycline Protocol

Author

De Deus Wagatsuma, Virginia Mara, Pereira-Martins, Diego A, Sánchez Mendoza, Silvia Elena, Koury, Luisa C A, Nascimento, Mariane Cristina, Melo, Raul Antônio Morais, Bittencourt, Rosane, Pagnano, Katia B, Pasquini, Ricardo, Chiattone, Carlos, Fagundes, Evandro Maranhão, Chauffaille, Maria de Lourdes, Lucena-Araujo, Antonio R., Tallman, Martin S., Schrier, Stanley L., Ribeiro, Raul C., Ganser, Arnold, Lowenberg, Bob, Lo Coco, Francesco, Sanz, Miguel A., Berliner, Nancy, and Rego, Eduardo Magalhães

Published
2017
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19. Clinical impact of BAALCexpression in high-risk acute promyelocytic leukemia

Author

Lucena-Araujo, Antonio R., Pereira-Martins, Diego A., Koury, Luisa C., Franca-Neto, Pedro L., Coelho-Silva, Juan L., de Deus Wagatsuma, Virginia M., Melo, Raul A.M., Bittencourt, Rosane, Pagnano, Katia, Pasquini, Ricardo, Chiattone, Carlos S., Fagundes, Evandro M., Chauffaille, Maria de Lourdes, Schrier, Stanley L., Tallman, Martin S., Ribeiro, Raul C., Grimwade, David, Ganser, Arnold, Löwenberg, Bob, Lo-Coco, Francesco, Sanz, Miguel A., Berliner, Nancy, and Rego, Eduardo M.

Abstract

Although overexpression of the brain and acute leukemia, cytoplasmic (BAALC) gene is associated with primary resistant disease and shorter relapse-free, disease-free, and overall survival in different subsets of acute myeloid leukemia (AML), little is known about its clinical impact in acute promyelocytic leukemia (APL). Using real-time reverse transcriptase polymerase chain reaction, we showed that BAALCexpression is significantly lower in APL compared with other subsets of AML (P≮ .001). We also demonstrated that BAALCoverexpression was associated with shorter disease-free survival (DFS) (hazard ratio [HR], 4.43; 95% confidence interval [CI], 1.29-15.2; P= .018) in 221 consecutive patients (median age, 35 years; range, 18-82 years) with newly diagnosed APL homogeneously treated with all-transretinoic acid and anthracycline-based chemotherapy. Cox proportional hazard modeling showed that BAALCoverexpression was independently associated with shorter DFS in the total cohort (HR, 5.26; 95% CI, 1.52-18.2; P= .009) and in patients with high-risk disease (ie, those with initial leukocyte counts >10 × 109/L) (HR, 5.3; 95% CI, 1.14-24.5; P= .033). We conclude that BAALCexpression could be useful for refining risk stratification in APL, although this needs to be confirmed in independent cohorts.

Published
2017
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20. Combining Gene Mutation with Gene Expression Data Improves Outcomes Prediction in Acute Promyelocytic Leukemia

Author

Lucena-Araujo, Antonio R., Pereira-Martins, Diego A., Koury, Luisa C. A., Coelho-Silva, Juan Luiz, Melo, Raul Antonio Morais, Bittencourt, Rosane, Pagnano, Katia B., Pasquini, Ricardo, Chiattone, Carlos, Fagundes, Evandro Maranhao, Chauffaille, Maria Lourdes, Schrier, Stanley L., Tallman, Martin S., Ribeiro, Raul C., Grimwade, David, Ganser, Arnold, Lowenberg, Bob, Lo Coco, Francesco, Sanz, Miguel A., Berliner, Nancy, and Eduardo Rego

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