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Your search keyword '"Kouji Azuhata"' showing total 2 results
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2 results on '"Kouji Azuhata"'

1. A Case of Double Primary Liver Cancer (Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma) without Hepatitis C Virus and Hepatitis B Virus Infection

Author

Eisuke Kondo, Yoshiaki Shimizu, Katsuhiko Ito, Kiyoshi Ogawa, Masaru Miyazaki, Kei Nishiya, Satoru Otawa, Takayuki Ishii, Kouji Azuhata, and Hirohisa Kishi

Subjects
Hepatitis B virus, business.industry, Hepatitis C virus, Hepatocellular carcinoma, Gastroenterology, medicine, Surgery, medicine.disease_cause, medicine.disease, business, Primary liver cancer, Virology, Intrahepatic Cholangiocarcinoma
Published
2012

2. Aberrant expression of human ortholog of mammalian enabled (hMena) in human colorectal carcinomas: implications for its role in tumor progression

Author

Kouji Azuhata, Morihiro Higashi, Hidetada Kawana, Hirohisa Kishi, Akihiro Toyoda, Kenichi Harigaya, Jianyong Yu, and Aya Omata

Subjects
Adenoma, Male, Cancer Research, Colon, Blotting, Western, Biology, Adenocarcinoma, Immunoenzyme Techniques, Tumor budding, Cell Movement, medicine, Tumor Cells, Cultured, Humans, RNA, Messenger, Aged, Oncogene, Reverse Transcriptase Polymerase Chain Reaction, Microfilament Proteins, Rectum, Cancer, Cell cycle, Middle Aged, medicine.disease, Molecular medicine, Adenocarcinoma, Mucinous, Oncology, Tumor progression, Cancer cell, Cancer research, Disease Progression, Immunohistochemistry, Female, Colorectal Neoplasms
Abstract

The human ortholog of mammalian enabled (hMena), a family of enabled/vasodilator-stimulated phosphoprotein (Ena/VASP), is an actin regulatory protein involved in the regulation of cell motility. Increasing evidence suggests that hMena over-expression is involved in human breast cancers, whereas the significance of hMena expression in colorectal carcinomas remains to be elucidated. In this study, we assessed the relative mRNA level of hMena using real-time PCR, showing that there is a statistically significant increase of hMena transcripts in matched human colorectal carcinomas and adjacent non-neoplastic colorectal epithelium (n=6, P=0.046). We also performed immunohistochemical analysis of the expression of hMena protein in 50 cases of paraffin-embedded archival colorectal tissues, and found that an elevated hMena expression is correlated to the cases with advanced TNM stages of colorectal carcinomas (P

Published
2008

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