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Tamsulosin hydrochloride is used to treat the symptoms of an enlarged prostate, a condition technically known as benign prostatic hyperplasia or BPH. The analyte was resolved by using Mobile phase (Potassium Dihydrogen Orthophosphate and Acetonitrile) at the flow rate of 1.2 Ml/Min. on Isocratic HPLC system consisting of Jasco Make UV visible Detector of model UV 1575 and Jasco make HPLC pump of model PU 1580. An ODS C- 8 RP Column (4.6mm ID, 250mm L, particle size 5 Micron, at wavelength of 280 Nm. The linearity range was found to be 0.4 Ml/Ml for Tamsulosin and 0.12 mg/ml to 2.0 mg/ml for its Impurity. The proposed method is simple, accurate, rapid and selective. Percent Relative standard Deviation was found to be very low, below 2.0%, which indicates that method is highly precise and specific. Short Analysis time (=10 min.) coupled with simplicity and ease of operation warrants use of the given method for analysis of Tamsulosin Hydrochloride along with its impurity as stated above in Bulk. Therefore, method can be useful in routine Quality Control Analysis in bulk drugs. [ABSTRACT FROM AUTHOR]

A simple, Precise, Rapid reproducible and selective reverse phase HPLC method has been developed for the estimation of Sibutramine Hydrochloride monohydrate and its Impurity in Bulk as well as Formulation. The analyte was resolved by using Mobile phase (Sodium Dihydrogen phosphate and Acetonitrile) at the flow rate of 1.0 M1/Min. on Isocratic HPLC system consisting of Jasco Make UV visible Detector of model UV 1575 & Jasco make HPLC pump of model PU 1580.An ODS C- 8 RP Column (4.6mm ID, 250mm L, particle size 5 Micron, at wavelength of 230 nm. [ABSTRACT FROM AUTHOR]

The plethora of drug therapies and types of drugs demand different formulations, fabrications conditions and release kinetics. No single polymer can satisfy all the requirements. Therefore there have been tremendous advances in area of biodegradable copolymers over the last 30 years. This article reviews current research on biodegradable polymers, focusing their potential as drug carries. The major classes of polymers are briefly discussed with regard to synthesis, properties and biodegradability, and known degradation modes and products are indicated based on studies reported in the literature. A vast majority of biodegradable polymers studied belongs to the polyester family, which includes polyglycolides and polylactides. Other degradable polymers such as polyorthoesters, polyanhydrides and polyphosphazenes are also discussed and their advantages and disadvantages are summarized. [ABSTRACT FROM AUTHOR]

In the present study a relatively simple method for the separation of husk from the seeds of Trigonella-foenum graecum (fenugreek) was developed. The entire seeds were subjected to size reduction followed by successive extractions with chlorinated hydrocarbons to separate the husk from the 'core and oily portion' to yield about 40%w/w of the husk. The dried husk was further powdered to 180 - 250 μ. It was characterized for various physicochemical parameters including swelling index, particle size distribution and flow properties. Use of fenugreek husk as a binding/granulating agent in solid dosage forms was also investigated. Diclofenac sodium and paracetamol were the model drugs of choice for optimizing the binding properties of husk in tablets using fenugreek husk dispersion, comparing the results against starch paste. Friability, hardness, disintegration, weight variation and dissolution were the parameters of comparative studies. Fenugreek husk dispersion was found to be superior over starch paste, on the basis of the selected parameters. The maximum concentration required of the husk as a binding agent was 4 -5% of the dosage form, which is relatively low as compared to starch. [ABSTRACT FROM AUTHOR]