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2. CBCT-to-CT synthesis with a single neural network for head-and-neck, lung and breast cancer adaptive radiotherapy

Author

Maspero, Matteo, Savenije, Mark HF, van Heijst, Tristan CF, Verhoeff, Joost JC, Kotte, Alexis NTJ, Houweling, Anette C, and Berg, Cornelis AT van den

Subjects
Physics - Medical Physics, Computer Science - Machine Learning, Electrical Engineering and Systems Science - Image and Video Processing
Abstract

Purpose: CBCT-based adaptive radiotherapy requires daily images for accurate dose calculations. This study investigates the feasibility of applying a single convolutional network to facilitate CBCT-to-CT synthesis for head-and-neck, lung, and breast cancer patients. Methods: Ninety-nine patients diagnosed with head-and-neck, lung or breast cancer undergoing radiotherapy with CBCT-based position verification were included in this study. CBCTs were registered to planning CTs according to clinical procedures. Three cycle-consistent generative adversarial networks (cycle-GANs) were trained in an unpaired manner on 15 patients per anatomical site generating synthetic-CTs (sCTs). Another network was trained with all the anatomical sites together. Performances of all four networks were compared and evaluated for image similarity against rescan CT (rCT). Clinical plans were recalculated on CT and sCT and analysed through voxel-based dose differences and {\gamma}-analysis. Results: A sCT was generated in 10 seconds. Image similarity was comparable between models trained on different anatomical sites and a single model for all sites. Mean dose differences < 0.5% were obtained in high-dose regions. Mean gamma (2%,2mm) pass-rates > 95% were achieved for all sites. Conclusions: Cycle-GAN reduced CBCT artefacts and increased HU similarity to CT, enabling sCT-based dose calculations. The speed of the network can facilitate on-line adaptive radiotherapy using a single network for head-and-neck, lung and breast cancer patients., Comment: Submitted to Medical Physics; 2019-12-23

Published
2019
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3. Impact of magnetic resonance-guided versus conventional radiotherapy workflows on organ at risk doses in stereotactic body radiotherapy for lymph node oligometastases

Author

Werensteijn-Honingh, Anita M., Kroon, Petra S., Winkel, Dennis, van Gaal, J. Carlijn, Hes, Jochem, Snoeren, Louk M.W., Timmer, Jaleesa K., Mout, Christiaan C.P., Bol, Gijsbert H., Kotte, Alexis N., Eppinga, Wietse S.C., Intven, Martijn, Raaymakers, Bas W., and Jürgenliemk-Schulz, Ina M.

Published
2022
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6. Inter-clinician delineation variation for a new highly-conformal flank target volume in children with renal tumors: A SIOP-Renal Tumor Study Group international multicenter exercise

Author

Mul, Joeri, Melchior, Patrick, Seravalli, Enrica, Saunders, Daniel, Bolle, Stephanie, Cameron, Alison L., Gurtner, Kristin, Harrabi, Semi, Lassen-Ramshad, Yasmin, Lavan, Naomi, Magelssen, Henriette, Mandeville, Henry, Boterberg, Tom, Kroon, Petra S., Kotte, Alexis N.T.J., Hoeben, Bianca A.W., van Rossum, Peter S.N., van Grotel, Martine, Graf, Norbert, van den Heuvel-Eibrink, Marry M., Rübe, Christian, and Janssens, Geert O.

Published
2021
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7. Consensus on Contouring Primary Breast Tumors on MRI in the Setting of Neoadjuvant Partial Breast Irradiation in Trials

Author

Vasmel, Jeanine E., Groot Koerkamp, Maureen L., Kirby, Anna M., Russell, Nicola S., Shaitelman, Simona F., Vesprini, Danny, Anandadas, Carmel N., Currey, Adam, Keller, Brian M., Braunstein, Lior Z., Han, Kathy, Kotte, Alexis N.T.J., de Waard, Stephanie N., Philippens, Marielle E.P., Houweling, Antonetta C., Verkooijen, Helena M., and van den Bongard, H.J.G. Desiree

Published
2020
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8. Automated dose evaluation on daily cone-beam computed tomography for breast cancer patients

Author

Radiotherapie, Experimentele klinische fysica, Cancer, Klinische Fysica RT, Groot Koerkamp, Maureen, Stijnman, Peter, Houweling, Antonetta, Zachiu, Cornel, Kotte, Alexis, Raaymakers, Bas, Radiotherapie, Experimentele klinische fysica, Cancer, Klinische Fysica RT, Groot Koerkamp, Maureen, Stijnman, Peter, Houweling, Antonetta, Zachiu, Cornel, Kotte, Alexis, and Raaymakers, Bas

Published
2024

9. Treatment robustness of total body irradiation with volumetric modulated arc therapy

Author

Klinische Fysica RT, Cancer, MS Radiotherapie, Seravalli, Enrica, Willemsen-Bosman, Mirjam, Zoetelief, Annelies, Roosenboom, Sanne, Harderwijk, Tessa, Krikke, Lean, Bol, Gijsbert, Kotte, Alexis, Huijboom, Eline, van Loon, Karel, Hoeben, Bianca, Klinische Fysica RT, Cancer, MS Radiotherapie, Seravalli, Enrica, Willemsen-Bosman, Mirjam, Zoetelief, Annelies, Roosenboom, Sanne, Harderwijk, Tessa, Krikke, Lean, Bol, Gijsbert, Kotte, Alexis, Huijboom, Eline, van Loon, Karel, and Hoeben, Bianca

Published
2024

10. Gross Tumor Delineation in Esophageal Cancer on MRI Compared With 18F-FDG-PET/CT

Author

Vollenbrock, Sophie E., Nowee, Marlies E., Voncken, Francine E.M., Kotte, Alexis N.T.J., Goense, Lucas, van Rossum, Peter S.N., van Lier, Astrid L.H.M.W., Heijmink, Stijn W., Bartels-Rutten, Annemarieke, Wessels, Frank J., Aleman, Berthe M.P., Dewit, Luc, Kerkmeijer, Linda G.W., Jansen, Edwin P.M., Intven, Martijn, Lips, Irene M., Meijer, Gert J., and Nijkamp, Jasper

Published
2019
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13. Pancreatic gross tumor volume contouring on computed tomography (CT) compared with magnetic resonance imaging (MRI): Results of an international contouring conference

Author

Hall, William A., Heerkens, Hanne D., Paulson, Eric S., Meijer, Gert J., Kotte, Alexis N., Knechtges, Paul, Parikh, Parag J., Bassetti, Michael F., Lee, Percy, Aitken, Katharine L., Palta, Manisha, Myrehaug, Sten, Koay, Eugene J., Portelance, Lorraine, Ben-Josef, Edgar, and Erickson, Beth A.

Published
2018
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16. Comprehensive Quantitative Evaluation of Variability in Magnetic Resonance-Guided Delineation of Oropharyngeal Gross Tumor Volumes and High-Risk Clinical Target Volumes: An R-IDEAL Stage 0 Prospective Study

Author

Cardenas, Carlos E., Blinde, Sanne E., Mohamed, Abdallah S. R., Ng, Sweet Ping, Raaijmakers, Cornelis, Philippens, Marielle, Kotte, Alexis, Al-Mamgani, Abrahim A., Karam, Irene, Thomson, David J., Robbins, Jared, Newbold, Kate, Fuller, Clifton D., Terhaard, Chris, Bahig, Houda, Blanchard, Pierre, Dehnad, Homan, Doornaert, Patricia, Elhalawani, Hesham, Frank, Steven J., Garden, Adam, Gunn, G. Brandon, Hamming-Vrieze, Olga, Kamal, Mona, Kasperts, Nicolien, Lee, Lip Wai, McDonald, Brigid A., McPartlin, Andrew, Meheissen, Mohamed AM, Morrison, William H., Navran, Arash, Nutting, Christopher M., Pameijer, Frank, Phan, Jack, Poon, Ian, Rosenthal, David I, Smid, Ernst J., and Sykes, Andrew J.

Subjects
Observer Variation, Cancer Research, Magnetic Resonance Spectroscopy, Radiation, Radiotherapy Planning, Computer-Assisted, Magnetic Resonance Imaging, Article, Tumor Burden, Oropharyngeal Neoplasms, Oncology, Head and Neck Neoplasms, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Retrospective Studies
Abstract

Tumor and target volume manual delineation remains a challenging task in head and neck cancer radiation therapy. The purpose of this study was to conduct a multi-institutional evaluation of manual delineations of gross tumor volume (GTV), high-risk clinical target volume (CTV), parotids, and submandibular glands on treatment simulation magnetic resonance scans of patients with oropharyngeal cancer.We retrospectively collected pretreatment T1-weighted, T1-weighted with gadolinium contrast, and T2-weighted magnetic resonance imaging scans for 4 patients with oropharyngeal cancer under an institution review board-approved protocol. We provided the scans to 26 radiation oncologists from 7 international cancer centers that participated in this delineation study. We also provide the patients' clinical history and physical examination findings, along with a medical photographic image and radiologic results. We used both the Simultaneous Truth and Performance Level Estimation algorithm and pair-wise comparisons of the contours, using overlap/distance metrics. Lastly, to assess experience and CTV delineation institutional practices, we had participants complete a brief questionnaire.Large variability was measured between observers' delineations for GTVs and CTVs. The mean Dice similarity coefficient values across all physicians' delineations for GTVp, GTVn, CTVp, and CTVn were 0.77, 0.67, 0.77, and 0.69, respectively, for Simultaneous Truth and Performance Level Estimation algorithm comparison, and 0.67, 0.60, 0.67, and 0.58, respectively, for pair-wise analysis. Normal tissue contours were defined more consistently when considering overlap/distance metrics. The median radiation oncology clinical experience was 7 years. The median experience delineating on magnetic resonance imaging was 3.5 years. The GTV-to-CTV margin used was 10 mm for 6 of 7 participant institutions. One institution used 8 mm, and 3 participants (from 3 different institutions) used a margin of 5 mm.The data from this study suggests that appropriate guidelines, contouring quality assurance sessions, and training are still needed for the adoption of magnetic resonance-based treatment planning for head and neck cancers. Such efforts should play a critical role in reducing delineation variation and ensure standardization of target design across clinical practices.

Published
2022
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17. Free-Form Registration Involving Disappearing Structures: Application to Brachytherapy MRI

Author

Berendsen, Floris F., Kotte, Alexis N. T. J., de Leeuw, Astrid A. C., Viergever, Max A., Pluim, Josien P. W., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Yoshida, Hiroyuki, editor, Warfield, Simon, editor, and Vannier, Michael W., editor

Published
2013
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18. Segmentation of Cervical Images by Inter-subject Registration with a Statistical Organ Model

Author

Berendsen, Floris F., van der Heide, Uulke A., Langerak, Thomas R., Kotte, Alexis N. T. J., Pluim, Josien P. W., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Yoshida, Hiroyuki, editor, Sakas, Georgios, editor, and Linguraru, Marius George, editor

Published
2012
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19. Online adaptive MR-guided radiotherapy: Conformity of contour adaptation for prostate cancer, rectal cancer and lymph node oligometastases among radiation therapists and radiation oncologists

Author

Rasing, Marnix J.A., primary, Sikkes, Gonda G., additional, Vissers, Nicole G.P.M., additional, Kotte, Alexis N.T.J., additional, Boudewijn, Joske H., additional, Doornaert, Patricia A.H., additional, Eppinga, Wietse S.C., additional, Intven, Martijn, additional, Rutgers, Reijer H.A., additional, Scheeren, Annick, additional, Snoeren, Louk M.W., additional, Vlig, Tiny B., additional, van der Voort van Zyp, Jochem R.N., additional, Wijkhuizen, Lisa M., additional, van Rossum, Peter S.N., additional, Peters, Max, additional, and Jürgenliemk-Schulz, Ina M., additional

Published
2022
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21. Online adaptive MR-guided radiotherapy: Conformity of contour adaptation for prostate cancer, rectal cancer and lymph node oligometastases among radiation therapists and radiation oncologists

Author

Onderzoek Radiotherapie, Cancer, Klinische Fysica RT, MS Radiotherapie, Arts-assistenten Radiotherapie, Rasing, Marnix J A, Sikkes, Gonda G, Vissers, Nicole G P M, Kotte, Alexis N T J, Boudewijn, Joske H, Doornaert, Patricia A H, Eppinga, Wietse S C, Intven, Martijn, Rutgers, Reijer H A, Scheeren, Annick, Snoeren, Louk M W, Vlig, Tiny B, van der Voort van Zyp, Jochem R N, Wijkhuizen, Lisa M, van Rossum, Peter S N, Peters, Max, Jürgenliemk-Schulz, Ina M, Onderzoek Radiotherapie, Cancer, Klinische Fysica RT, MS Radiotherapie, Arts-assistenten Radiotherapie, Rasing, Marnix J A, Sikkes, Gonda G, Vissers, Nicole G P M, Kotte, Alexis N T J, Boudewijn, Joske H, Doornaert, Patricia A H, Eppinga, Wietse S C, Intven, Martijn, Rutgers, Reijer H A, Scheeren, Annick, Snoeren, Louk M W, Vlig, Tiny B, van der Voort van Zyp, Jochem R N, Wijkhuizen, Lisa M, van Rossum, Peter S N, Peters, Max, and Jürgenliemk-Schulz, Ina M

Published
2022

22. Impact of magnetic resonance-guided versus conventional radiotherapy workflows on organ at risk doses in stereotactic body radiotherapy for lymph node oligometastases

Author

Cancer, Klinische Fysica RT, Experimentele klinische fysica, Arts-assistenten Radiotherapie, MS Radiotherapie, Werensteijn-Honingh, Anita M, Kroon, Petra S, Winkel, Dennis, van Gaal, J Carlijn, Hes, Jochem, Snoeren, Louk M W, Timmer, Jaleesa K, Mout, Christiaan C P, Bol, Gijsbert H, Kotte, Alexis N, Eppinga, Wietse S C, Intven, Martijn, Raaymakers, Bas W, Jürgenliemk-Schulz, Ina M, Cancer, Klinische Fysica RT, Experimentele klinische fysica, Arts-assistenten Radiotherapie, MS Radiotherapie, Werensteijn-Honingh, Anita M, Kroon, Petra S, Winkel, Dennis, van Gaal, J Carlijn, Hes, Jochem, Snoeren, Louk M W, Timmer, Jaleesa K, Mout, Christiaan C P, Bol, Gijsbert H, Kotte, Alexis N, Eppinga, Wietse S C, Intven, Martijn, Raaymakers, Bas W, and Jürgenliemk-Schulz, Ina M

Published
2022

23. Comprehensive Quantitative Evaluation of Variability in Magnetic Resonance-Guided Delineation of Oropharyngeal Gross Tumor Volumes and High-Risk Clinical Target Volumes: An R-IDEAL Stage 0 Prospective Study

Author

Arts-assistenten Radiotherapie, Klinische Fysica RT, Cancer, MS Radiotherapie, Cardenas, Carlos E., Blinde, Sanne E., Mohamed, Abdallah S.R., Ng, Sweet Ping, Raaijmakers, Cornelis, Philippens, Marielle, Kotte, Alexis, Al-Mamgani, Abrahim A., Karam, Irene, Thomson, David J., Robbins, Jared, Newbold, Kate, Fuller, Clifton D., Terhaard, Chris, Arts-assistenten Radiotherapie, Klinische Fysica RT, Cancer, MS Radiotherapie, Cardenas, Carlos E., Blinde, Sanne E., Mohamed, Abdallah S.R., Ng, Sweet Ping, Raaijmakers, Cornelis, Philippens, Marielle, Kotte, Alexis, Al-Mamgani, Abrahim A., Karam, Irene, Thomson, David J., Robbins, Jared, Newbold, Kate, Fuller, Clifton D., and Terhaard, Chris

Published
2022

29. Comparison of Library of Plans with two daily adaptive strategies for whole bladder radiotherapy

Author

Radiotherapie, Klinische Fysica RT, Cancer, MS Radiotherapie, Arts-assistenten Radiotherapie, Onderzoek Radiotherapie, den Boer, Duncan, den Hartogh, Mariska D., Kotte, Alexis N.T.J., van der Voort van Zyp, Jochem R.N., Noteboom, Juus L., Bol, Gijsbert H., Willigenburg, Thomas, Werensteijn-Honingh, Anita M., Jürgenliemk-Schulz, Ina M., van Lier, Astrid L.H.M.W., Kroon, Petra S., Radiotherapie, Klinische Fysica RT, Cancer, MS Radiotherapie, Arts-assistenten Radiotherapie, Onderzoek Radiotherapie, den Boer, Duncan, den Hartogh, Mariska D., Kotte, Alexis N.T.J., van der Voort van Zyp, Jochem R.N., Noteboom, Juus L., Bol, Gijsbert H., Willigenburg, Thomas, Werensteijn-Honingh, Anita M., Jürgenliemk-Schulz, Ina M., van Lier, Astrid L.H.M.W., and Kroon, Petra S.

Published
2021

30. An in-silico assessment of the dosimetric benefits of MR-guided radiotherapy for esophageal cancer patients

Author

Cancer, Fysica Radiotherapie Research, Arts Assistenten CTC, MS CGO, Klinische Fysica RT, MS Radiotherapie, Boekhoff, Mick, Defize, Ingmar, Borggreve, Alicia, van Hillegersberg, Richard, Kotte, Alexis, Lagendijk, Jan, van Lier, Astrid, Ruurda, Jelle, Takahashi, Noriyoshi, Mook, Stella, Meijer, Gert, Cancer, Fysica Radiotherapie Research, Arts Assistenten CTC, MS CGO, Klinische Fysica RT, MS Radiotherapie, Boekhoff, Mick, Defize, Ingmar, Borggreve, Alicia, van Hillegersberg, Richard, Kotte, Alexis, Lagendijk, Jan, van Lier, Astrid, Ruurda, Jelle, Takahashi, Noriyoshi, Mook, Stella, and Meijer, Gert

Published
2021

31. Inter-clinician delineation variation for a new highly-conformal flank target volume in children with renal tumors: A SIOP-Renal Tumor Study Group international multicenter exercise

Author

Klinische Fysica RT, Cancer, MS Radiotherapie, Arts-assistenten Radiotherapie, PMC Medisch specialisten, Speerpunt, Zorg en O&O, Child Health, Mul, Joeri, Melchior, Patrick, Seravalli, Enrica, Saunders, Daniel, Bolle, Stephanie, Cameron, Alison L., Gurtner, Kristin, Harrabi, Semi, Lassen-Ramshad, Yasmin, Lavan, Naomi, Magelssen, Henriette, Mandeville, Henry, Boterberg, Tom, Kroon, Petra S., Kotte, Alexis N.T.J., Hoeben, Bianca A.W., van Rossum, Peter S.N., van Grotel, Martine, Graf, Norbert, van den Heuvel-Eibrink, Marry M., Rübe, Christian, Janssens, Geert O., Klinische Fysica RT, Cancer, MS Radiotherapie, Arts-assistenten Radiotherapie, PMC Medisch specialisten, Speerpunt, Zorg en O&O, Child Health, Mul, Joeri, Melchior, Patrick, Seravalli, Enrica, Saunders, Daniel, Bolle, Stephanie, Cameron, Alison L., Gurtner, Kristin, Harrabi, Semi, Lassen-Ramshad, Yasmin, Lavan, Naomi, Magelssen, Henriette, Mandeville, Henry, Boterberg, Tom, Kroon, Petra S., Kotte, Alexis N.T.J., Hoeben, Bianca A.W., van Rossum, Peter S.N., van Grotel, Martine, Graf, Norbert, van den Heuvel-Eibrink, Marry M., Rübe, Christian, and Janssens, Geert O.

Published
2021

35. Feasibility of stereotactic radiotherapy using a 1.5 T MR-linac: Multi-fraction treatment of pelvic lymph node oligometastases

Author

Werensteijn-Honingh, Anita M., Kroon, Petra S., Winkel, Dennis, Aalbers, Ellart M., van Asselen, Bram, Bol, Gijsbert H., Brown, Kevin J., Eppinga, Wietse S.C., van Es, Corine A., Glitzner, Markus, de Groot-van Breugel, Eline N., Hackett, Sara L., Intven, Martijn, Kok, Jan G.M., Kontaxis, Charis, Kotte, Alexis N., Lagendijk, Jan J.W., Philippens, Mariëlle E.P., Tijssen, Rob H.N., Wolthaus, Jochem W.H., Woodings, Simon J., Raaymakers, Bas W., and Jürgenliemk-Schulz, Ina M.

Published
2019
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36. Knowledge-Based Assessment of Focal Dose Escalation Treatment Plans in Prostate Cancer

Author

van Schie, Marcel A., primary, Janssen, Tomas M., additional, Eekhout, Dave, additional, Walraven, Iris, additional, Pos, Floris J., additional, de Ruiter, Peter, additional, Kotte, Alexis N.T.J., additional, Monninkhof, Evelyn M., additional, Kerkmeijer, Linda G.W., additional, Draulans, Cédric, additional, de Roover, Robin, additional, Haustermans, Karin, additional, Kunze-Busch, Martina, additional, Smeenk, Robert Jan, additional, and van der Heide, Uulke A., additional

Published
2020
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38. A flexible algorithm for construction of 3-D vessel networks for use in thermal modeling

Author

Van Leeuwen, Gerard M.J., Kotte, Alexis N.T.J., and Lagendijk, Jan J.W.

Subjects
Blood vessels -- Models, Computer simulation -- Usage, Biological sciences, Business, Computers, Health care industry
Abstract

A new algorithm for the construction of artificial blood vessel networks is presented. The algorithm produces three-dimensional (3-D) geometrical representations of both arterial and venous networks. The key ingredient of the algorithm is a 3-D potential function defined in the tissue volume. This potential function controls the paths by which points are connected to existing vessels, thereby producing new vessel segments. The potential function has no physiological interpretation, but, by adjustment of parameters governing the potential, it is possible to produce networks that have physiologically meaningful geometrical properties. If desired, the veins can be generated counter current to the arteries. Furthermore, the potential function allows fashioning of the networks to the presence of bone or air cavities. The resulting networks can be used for thermal simulations of hyperthermia treatment. Index Terms - Counter current vessels, hyperthermia, network analysis, thermal modeling, vessel network generation.

Published
1998

39. Knowledge-Based Assessment of Focal Dose Escalation Treatment Plans in Prostate Cancer

Author

MS Radiotherapie, Klinische Fysica RT, Cancer, Epi Kanker Team A, JC onderzoeksprogramma Kanker, van Schie, Marcel A, Janssen, Tomas M, Eekhout, Dave, Walraven, Iris, Pos, Floris J, de Ruiter, Peter, Kotte, Alexis N T J, Monninkhof, Evelyn M, Kerkmeijer, Linda G W, Draulans, Cédric, de Roover, Robin, Haustermans, Karin, Kunze-Busch, Martina, Smeenk, Robert Jan, van der Heide, Uulke A, MS Radiotherapie, Klinische Fysica RT, Cancer, Epi Kanker Team A, JC onderzoeksprogramma Kanker, van Schie, Marcel A, Janssen, Tomas M, Eekhout, Dave, Walraven, Iris, Pos, Floris J, de Ruiter, Peter, Kotte, Alexis N T J, Monninkhof, Evelyn M, Kerkmeijer, Linda G W, Draulans, Cédric, de Roover, Robin, Haustermans, Karin, Kunze-Busch, Martina, Smeenk, Robert Jan, and van der Heide, Uulke A

Published
2020

40. Consensus on Contouring Primary Breast Tumors on MRI in the Setting of Neoadjuvant Partial Breast Irradiation in Trials

Author

Trialbureau Beeld, Fysica Radiotherapie Research, Cancer, Klinische Fysica RT, MS Radiologie, JC onderzoeksprogramma Kanker, Epi Kanker Team A, Vasmel, Jeanine E, Groot Koerkamp, Maureen L, Kirby, Anna M, Russell, Nicola S, Shaitelman, Simona F, Vesprini, Danny, Anandadas, Carmel N, Currey, Adam, Keller, Brian M, Braunstein, Lior Z, Han, Kathy, Kotte, Alexis N T J, de Waard, Stephanie N, Philippens, Marielle E P, Houweling, Antonetta C, Verkooijen, Helena M, van den Bongard, H J G Desiree, Trialbureau Beeld, Fysica Radiotherapie Research, Cancer, Klinische Fysica RT, MS Radiologie, JC onderzoeksprogramma Kanker, Epi Kanker Team A, Vasmel, Jeanine E, Groot Koerkamp, Maureen L, Kirby, Anna M, Russell, Nicola S, Shaitelman, Simona F, Vesprini, Danny, Anandadas, Carmel N, Currey, Adam, Keller, Brian M, Braunstein, Lior Z, Han, Kathy, Kotte, Alexis N T J, de Waard, Stephanie N, Philippens, Marielle E P, Houweling, Antonetta C, Verkooijen, Helena M, and van den Bongard, H J G Desiree

Published
2020

41. A single neural network for cone-beam computed tomography-based radiotherapy of head-and-neck, lung and breast cancer

Author

Computational Imaging, Cancer, Klinische Fysica RT, Fysica Radiotherapie Research, MS Radiotherapie, Maspero, Matteo, Houweling, Antonetta C., Savenije, Mark H.F., van Heijst, Tristan C.F., Verhoeff, Joost J.C., Kotte, Alexis N.T.J., van den Berg, Cornelis A.T., Computational Imaging, Cancer, Klinische Fysica RT, Fysica Radiotherapie Research, MS Radiotherapie, Maspero, Matteo, Houweling, Antonetta C., Savenije, Mark H.F., van Heijst, Tristan C.F., Verhoeff, Joost J.C., Kotte, Alexis N.T.J., and van den Berg, Cornelis A.T.

Published
2020

43. Single blind randomized Phase III trial to investigate the benefit of a focal lesion ablative microboost in prostate cancer (FLAME-trial): study protocol for a randomized controlled trial

Author

Lips Irene M, van der Heide Uulke A, Haustermans Karin, van Lin Emile NJT, Pos Floris, Franken Stefan PG, Kotte Alexis NTJ, van Gils Carla H, and van Vulpen Marco

Subjects
microboost, prostate cancer, external beam radiotherapy, FLAME-trial, Medicine (General), R5-920
Abstract

Abstract Background The treatment results of external beam radiotherapy for intermediate and high risk prostate cancer patients are insufficient with five-year biochemical relapse rates of approximately 35%. Several randomized trials have shown that dose escalation to the entire prostate improves biochemical disease free survival. However, further dose escalation to the whole gland is limited due to an unacceptable high risk of acute and late toxicity. Moreover, local recurrences often originate at the location of the macroscopic tumor, so boosting the radiation dose at the macroscopic tumor within the prostate might increase local control. A reduction of distant metastases and improved survival can be expected by reducing local failure. The aim of this study is to investigate the benefit of an ablative microboost to the macroscopic tumor within the prostate in patients treated with external beam radiotherapy for prostate cancer. Methods/Design The FLAME-trial (Focal Lesion Ablative Microboost in prostatE cancer) is a single blind randomized controlled phase III trial. We aim to include 566 patients (283 per treatment arm) with intermediate or high risk adenocarcinoma of the prostate who are scheduled for external beam radiotherapy using fiducial markers for position verification. With this number of patients, the expected increase in five-year freedom from biochemical failure rate of 10% can be detected with a power of 80%. Patients allocated to the standard arm receive a dose of 77 Gy in 35 fractions to the entire prostate and patients in the experimental arm receive 77 Gy to the entire prostate and an additional integrated microboost to the macroscopic tumor of 95 Gy in 35 fractions. The secondary outcome measures include treatment-related toxicity, quality of life and disease-specific survival. Furthermore, by localizing the recurrent tumors within the prostate during follow-up and correlating this with the delivered dose, we can obtain accurate dose-effect information for both the macroscopic tumor and subclinical disease in prostate cancer. The rationale, study design and the first 50 patients included are described. Trial registration This study is registered at ClinicalTrials.gov: NCT01168479

Published
2011
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44. Feasibility of stereotactic radiotherapy using a 1.5 T MR-linac : Multi-fraction treatment of pelvic lymph node oligometastases

Author

Werensteijn-Honingh, Anita M, Kroon, Petra S, Winkel, Dennis, Aalbers, Ellart M, van Asselen, Bram, Bol, Gijsbert H, Brown, Kevin J, Eppinga, Wietse S C, van Es, Corine A, Glitzner, Markus, de Groot-van Breugel, Eline N, Hackett, Sara L, Intven, Martijn, Kok, Jan G M, Kontaxis, Charis, Kotte, Alexis N, Lagendijk, Jan J W, Philippens, Mariëlle E P, Tijssen, Rob H N, Wolthaus, Jochem W H, Woodings, Simon J, Raaymakers, Bas W, Jürgenliemk-Schulz, Ina M, Werensteijn-Honingh, Anita M, Kroon, Petra S, Winkel, Dennis, Aalbers, Ellart M, van Asselen, Bram, Bol, Gijsbert H, Brown, Kevin J, Eppinga, Wietse S C, van Es, Corine A, Glitzner, Markus, de Groot-van Breugel, Eline N, Hackett, Sara L, Intven, Martijn, Kok, Jan G M, Kontaxis, Charis, Kotte, Alexis N, Lagendijk, Jan J W, Philippens, Mariëlle E P, Tijssen, Rob H N, Wolthaus, Jochem W H, Woodings, Simon J, Raaymakers, Bas W, and Jürgenliemk-Schulz, Ina M

Published
2019

45. Gross Tumor Delineation in Esophageal Cancer on MRI Compared With 18F-FDG-PET/CT

Author

Vollenbrock, Sophie E, Nowee, Marlies E, Voncken, Francine E M, Kotte, Alexis N T J, Goense, Lucas, van Rossum, Peter S N, van Lier, Astrid L H M W, Heijmink, Stijn W, Bartels-Rutten, Annemarieke, Wessels, Frank J, Aleman, Berthe M P, Dewit, Luc, Kerkmeijer, Linda G W, Jansen, Edwin P M, Intven, Martijn, Lips, Irene M, Meijer, Gert J, Nijkamp, Jasper, Vollenbrock, Sophie E, Nowee, Marlies E, Voncken, Francine E M, Kotte, Alexis N T J, Goense, Lucas, van Rossum, Peter S N, van Lier, Astrid L H M W, Heijmink, Stijn W, Bartels-Rutten, Annemarieke, Wessels, Frank J, Aleman, Berthe M P, Dewit, Luc, Kerkmeijer, Linda G W, Jansen, Edwin P M, Intven, Martijn, Lips, Irene M, Meijer, Gert J, and Nijkamp, Jasper

Published
2019

46. Gross Tumor Delineation in Esophageal Cancer on MRI Compared With 18F-FDG-PET/CT

Author

Klinische Fysica RT, Cancer, MS CGO, Arts-assistenten Radiotherapie, MS Radiologie, MS Radiotherapie, Vollenbrock, Sophie E, Nowee, Marlies E, Voncken, Francine E M, Kotte, Alexis N T J, Goense, Lucas, van Rossum, Peter S N, van Lier, Astrid L H M W, Heijmink, Stijn W, Bartels-Rutten, Annemarieke, Wessels, Frank J, Aleman, Berthe M P, Dewit, Luc, Kerkmeijer, Linda G W, Jansen, Edwin P M, Intven, Martijn, Lips, Irene M, Meijer, Gert J, Nijkamp, Jasper, Klinische Fysica RT, Cancer, MS CGO, Arts-assistenten Radiotherapie, MS Radiologie, MS Radiotherapie, Vollenbrock, Sophie E, Nowee, Marlies E, Voncken, Francine E M, Kotte, Alexis N T J, Goense, Lucas, van Rossum, Peter S N, van Lier, Astrid L H M W, Heijmink, Stijn W, Bartels-Rutten, Annemarieke, Wessels, Frank J, Aleman, Berthe M P, Dewit, Luc, Kerkmeijer, Linda G W, Jansen, Edwin P M, Intven, Martijn, Lips, Irene M, Meijer, Gert J, and Nijkamp, Jasper

Published
2019

47. Feasibility of stereotactic radiotherapy using a 1.5 T MR-linac: Multi-fraction treatment of pelvic lymph node oligometastases

Author

Onderzoek Radiotherapie, Cancer, Klinische Fysica RT, MS Radiotherapie, Fysica Radiotherapie Research, Experimentele klinische fysica, Werensteijn-Honingh, Anita M, Kroon, Petra S, Winkel, Dennis, Aalbers, Ellart M, van Asselen, Bram, Bol, Gijsbert H, Brown, Kevin J, Eppinga, Wietse S C, van Es, Corine A, Glitzner, Markus, de Groot-van Breugel, Eline N, Hackett, Sara L, Intven, Martijn, Kok, Jan G M, Kontaxis, Charis, Kotte, Alexis N, Lagendijk, Jan J W, Philippens, Mariëlle E P, Tijssen, Rob H N, Wolthaus, Jochem W H, Woodings, Simon J, Raaymakers, Bas W, Jürgenliemk-Schulz, Ina M, Onderzoek Radiotherapie, Cancer, Klinische Fysica RT, MS Radiotherapie, Fysica Radiotherapie Research, Experimentele klinische fysica, Werensteijn-Honingh, Anita M, Kroon, Petra S, Winkel, Dennis, Aalbers, Ellart M, van Asselen, Bram, Bol, Gijsbert H, Brown, Kevin J, Eppinga, Wietse S C, van Es, Corine A, Glitzner, Markus, de Groot-van Breugel, Eline N, Hackett, Sara L, Intven, Martijn, Kok, Jan G M, Kontaxis, Charis, Kotte, Alexis N, Lagendijk, Jan J W, Philippens, Mariëlle E P, Tijssen, Rob H N, Wolthaus, Jochem W H, Woodings, Simon J, Raaymakers, Bas W, and Jürgenliemk-Schulz, Ina M

Published
2019

48. Non-rigid CT/CBCT to CBCT registration for online external beam radiotherapy guidance

Author

Zachiu, Cornel, Denis De Senneville, Baudouin, Tijssen, Rob, Kotte, Alexis, Houweling, Antonetta, Kerkmeijer, Linda, Lagendijk, Jan, Moonen, Chrit, Ries, Mario, University Medical Center [Utrecht], Imagerie moléculaire et fonctionnelle: de la physiologie à la thérapie, Université Bordeaux Segalen - Bordeaux 2-IFR8-Centre National de la Recherche Scientifique (CNRS), Imaging Division, and Denis De Senneville, Baudouin

Subjects
Image-guided radiotherapy, CT/CBCT registration, Online guidance, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing
Abstract

International audience; Image-guided external beam radiotherapy (EBRT) allows radiation dose deposition with a high degree of accuracy and precision. Guidance is usually achieved by estimating the displacements, via image registration, between cone beam computed tomography (CBCT) and computed tomography (CT) images acquired at different stages of the therapy. The resulting displacements are then used to reposition the patient such that the location of the tumor at the time of treatment matches its position during planning. Moreover, ongoing research aims to use CBCT-CT image registration for online plan adaptation. However, CBCT images are usually acquired using a small number of X-Ray projections and/or low beam intensities. This often leads to the images being subject to low contrast, low signal-to-noise ratio and artifacts, which ends-up hampering the image registration process. Previous studies addressed this by integrating additional image processing steps into the registration procedure. However, these steps are usually designed for particular image acquisition schemes, therefore limiting their use on a case-by-case basis. In the current study we address CT to CBCT and CBCT to CBCT registration by the means of the recently proposed EVolution registration algorithm. Contrary to previous approaches, EVolution does not require the integration of additional image processing steps in the registration scheme. Moreover, the algorithm requires a low number of input parameters, is easily parallelizable and provides an elastic deformation on a point-by-point basis. Results have shown that for typical CBCT images, the intrinsic image artifacts only have a sub-millimeter impact on the accuracy and precision of the estimated deformation. In addition, the algorithm has low computational requirements, which are compatible with online image-based guidance of EBRT treatments.

Published
2018

49. Contouring of prostate tumors on multiparametric MRI : Evaluation of clinical delineations in a multicenter radiotherapy trial

Author

van Schie, Marcel A, Dinh, Cuong V, Houdt, Petra J van, Pos, Floris J, Heijmink, Stijn W T J P, Kerkmeijer, Linda G W, Kotte, Alexis N T J, Oyen, Raymond, Haustermans, Karin, van der Heide, Uulke A, van Schie, Marcel A, Dinh, Cuong V, Houdt, Petra J van, Pos, Floris J, Heijmink, Stijn W T J P, Kerkmeijer, Linda G W, Kotte, Alexis N T J, Oyen, Raymond, Haustermans, Karin, and van der Heide, Uulke A

Published
2018

50. Contouring of prostate tumors on multiparametric MRI: Evaluation of clinical delineations in a multicenter radiotherapy trial

Author

MS Radiotherapie, Cancer, Klinische Fysica RT, van Schie, Marcel A, Dinh, Cuong V, Houdt, Petra J van, Pos, Floris J, Heijmink, Stijn W T J P, Kerkmeijer, Linda G W, Kotte, Alexis N T J, Oyen, Raymond, Haustermans, Karin, van der Heide, Uulke A, MS Radiotherapie, Cancer, Klinische Fysica RT, van Schie, Marcel A, Dinh, Cuong V, Houdt, Petra J van, Pos, Floris J, Heijmink, Stijn W T J P, Kerkmeijer, Linda G W, Kotte, Alexis N T J, Oyen, Raymond, Haustermans, Karin, and van der Heide, Uulke A

Published
2018

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