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1. Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions)

Author

Elfgen, Constanze, Leo, Cornelia, Kubik-Huch, Rahel A., Muenst, Simone, Schmidt, Noemi, Quinn, Cecily, McNally, Sorcha, van Diest, Paul J., Mann, Ritse M, Bago-Horvath, Zsuzsanna, Bernathova, Maria, Regitnig, Peter, Fuchsjäger, Michael, Schwegler-Guggemos, Daniela, Maranta, Martina, Zehbe, Sabine, Tausch, Christoph, Güth, Uwe, Fallenberg, Eva Maria, Schrading, Simone, Kothari, Ashutosh, Sonnenschein, Martin, Kampmann, Gert, Kulka, Janina, Tille, Jean-Christophe, Körner, Meike, Decker, Thomas, Lax, Sigurd F., Daniaux, Martin, Bjelic-Radisic, Vesna, Kacerovsky-Strobl, Stephanie, Condorelli, Rosaria, Gnant, Michael, and Varga, Zsuzsanna

Published
2023
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5. HER2-enriched subtype and novel molecular subgroups drive aromatase inhibitor resistance and an increased risk of relapse in early ER+/HER2+ breast cancer

Author

Evans, Abigail, Ball, Adrian, Johri, Akhil, Nejim, Ali, Jones, Alison, Corder, Allan, Thorne, Amanda, Anand, Ambika, Chakrabarti, Amitabha, Robinson, Anne, Skene, Anthony, Modi, Anupam, Patel, Ashraf, Kothari, Ashutosh, McFall, Brendan, Mortimer, Caroline, Lee, Caroline, Chan, Charlie, Abson, Charlotte, Holcombe, Christopher, Hinton, Christopher, Hollywood, Ciaran, Murphy, Claire, Crowley, Clare, Harding-Mackean, Claudia, Griffith, Clive, Lewanski, Conrad, Rea, Daniel, Hwang, David, Crawford, Derek, Thekkinkattil, Dinesh, Ferguson, Douglas, Adamson, Douglas, Wheatley, Duncan, Ravichandran, Duraisamy, Babu, Ed, Hyett, Elaine, Ashkanani, Fawzia, Hoar, Fiona, Kenny, Frances, Dyke, Gary, Sparrow, Geoffrey, Gilbert, Cunnick, Giles, Algurafi, Hafiz, Sweetland, Helen, Prof, Highes-Davies, Hamed, Hisham, Smith, Ian, Laidlaw, Ian, Khattak, Ilyas, Newby, Jacqueline, Rees-Lee, Jacqueline, Kokan, Jalal, Barrett, Jane, Naik, Jay Dolatrai, Vaidya, Jayant, Forrest, Jennifer, Parmar, Jitendra, Adams, Jocelyn, Fox, John, Roberts, Jonathan, Dawson, Jonathan, Doughty, Julie, Donnelly, Jull, Dunn, Kathleen, Chin, Kian, Horgan, Kieran, Thakur, Kislaya, Barthelmes, Ludger, Wyld, Lynda, Bhattacharyya, Madhumita, Hadaki, Maher, Kishore, Makam, Ornstein, Marcus, Bramley, Maria, Bews-Hair, Maria, Parton, Marina, Sibbering, Mark, Kissin, Mark, Churn, Mark, Hogg, Martin, Quigley, Mary, Hatton, Matthew, Winter, Matthew, Adelekan, Matthew, Shere, Michael, Carr, Michael, Williams, Michael, Absar, Mohammed, Sharif, Muhammad, Kelleher, Muireann, Walji, Nawaz, Williams, Nicholas, Gallegos, Nicholas, Bundred, Nigel, Hatcher, Olivia, Crellin, Perric, Crane, Peter, Donnelly, Peter, Kneeshaw, Peter, Walker, Philip, Sinha, Prakash, Bhaskar, Pudhupalayam, Soulsby, Racheal, Todd, Radha, Vidya, Raghavan, Mehra, Rakesh, Prasad, Ramachandran, Cutress, Ramsay, Sharma, Ravi, Roylance, Rebecca, Goranova, Rebecca, Salman, Reem Ramzi, Bonom, Riccardo, Johnson, Richard, Sutton, Richard, Linforth, Rick, Coleman, Rob, Grieve, Robert, Leonard, Robert, Reichert, Robert, Kennedy, Robert, Agarwal, Roshan, Allerton, Rozenn, Burcombe, Russell, Davis, Ruth, Narayanan, Sankaran, Chandrasekharan, Sankaran, Vesty, Sarah, Seetharam, Seema, Ledwidge, Serena, Iqbal, Shabana, Wahee, Shamaela, Silva, Shobha, Pain, Simon, Holt, Simon, Thomson, Simon, Smith, Simon, Ellenbogen, Simon, Laws, Siobhan, Chan, Stephen, Johnston, Stephen, Holt, Steve, Thrush, Steven, McIntosh, Stuart, Chatterjee, Sumohan, Cleator, Susan, Usman, Tamoor, Johnson, Tayo, Kovacs, Tibor, Irvine, Tracey, Barthkur, Urmila, Pope, Vanessa, Brown, Victoria Alexandra, Muralikrishna, Vummiti, Samra, Walid, Maxwell, William, Winters, Zoe, Bergamino, Milana A., López-Knowles, Elena, Morani, Gabriele, Tovey, Holly, Kilburn, Lucy, Schuster, Eugene F., Alataki, Anastasia, Hills, Margaret, Xiao, Hui, Holcombe, Chris, Robertson, John F., Smith, Ian E., Bliss, Judith M., Dowsett, Mitch, and Cheang, Maggie C.U.

Published
2022
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9. Cerenkov Luminescence Imaging and Flexible Autoradiography for specimen margin assessment during breast-conserving cancer surgery

Author

Sinha, Aaditya, primary, Peterson, Zhane, additional, Shifa, Belul, additional, Jeffery, Hannah, additional, Jurrius, Patriek, additional, Allen, Sarah, additional, Lee, Eugene, additional, Azmat, Mohammed, additional, Barrass, Rachel, additional, Bailey, Damion, additional, Johnson, Jessica, additional, Adamson, Kathryn, additional, Karydakis, Vasileios, additional, Shaari, Elina, additional, Thorat, Mangesh, additional, Hamed, Hisham, additional, Bitsakou, Georgina, additional, Pinder, Sarah, additional, Menon, Padma, additional, Ng, Wen, additional, Cook, Gary, additional, Joemon, John, additional, Jacob, Armidita, additional, Pereira, Sofia, additional, Thomas, Jocelyn, additional, Begum, Ruheana, additional, El-Boghdadly, Karim, additional, Van Hemelrijck, Mieke, additional, Kothari, Ashutosh, additional, and Purushotham, Arnie, additional

Published
2024
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14. Augmentation of a multidisciplinary team meeting with a clinical decision support system to triage breast cancer patients in the United Kingdom

Author

Martin, Martha, primary, Kristeleit, Hartmut, additional, Ruta, Danny, additional, Karampera, Christina, additional, Hekmat, Rezzan, additional, Felix, Winnie, additional, InHout, Bertha, additional, Kothari, Ashutosh, additional, Kazmi, Majid, additional, Ledwaba-Chapman, Lesedi, additional, Clery, Amanda, additional, Wang, Yanzhong, additional, Coker, Bola, additional, Preininger, Anita M, additional, Vergis, Roy, additional, Eggebraaten, Thomas, additional, Gloe, Chris, additional, Irene, Irene Dankwa-Mullan, additional, Jackson, Gretchen Purcell, additional, and Rigg, Anne, additional

Published
2023
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18. Chest wall perforator flaps for breast reconstruction : international survey on attitudes and training needs

Author

Karakatsanis, Andreas, Sund, Malin, Rocco, Nicola, Dietz, Jill R., Kothari, Ashutosh, Hamdi, Mustapha, Masannat, Yazan A., Barry, Peter A., Karakatsanis, Andreas, Sund, Malin, Rocco, Nicola, Dietz, Jill R., Kothari, Ashutosh, Hamdi, Mustapha, Masannat, Yazan A., and Barry, Peter A.

Abstract

Background Volume replacement using chest wall perforator flaps (CWPFs) is a promising technique to reduce mastectomy rates without sacrificing function or aesthetics. Owing to limited availability of the technique, only a minority of patients currently have access to CWPF procedures. Methods An international web-based survey was disseminated through social media, dedicated webpages, and national and international societies for breast surgery. The survey explored surgeons' attitudes towards CWPFs and their perceived training needs. Results Of 619 respondents, 88.4 per cent agreed that CWPF surgery was desirable, with one-third offering it and performing a median of 10 (i.q.r. 5-15) procedures annually. They were more likely to be senior (OR 1.35, 95 per cent c.i. 1.18 to 1.55; P < 0.001), with formal oncoplastic training (OR 4.80, 3.09 to 7.48; P < 0.001), and working in larger units (OR 1.18, 1.03 to 1.35; P = 0.018) with a free-flap (OR 1.62, 1.06 to 2.48; P = 0.025) or CWPF (OR 3.02, 1.87 to 4.89; P < 0.001) service available. In cluster and latent class analysis, none showed high cohesion with performance of CWPF surgery. Conclusion There is a discrepancy between perceived importance and availability of CWPF surgery, indicating that optimal training is needed. Chest wall perforator flap reconstruction is an attractive oncoplastic technique that still needs to be standardized and disseminated. In an international survey of 620 respondents across the world, it was seen that, although most surgeons feel that the technique is important, very few are offering it and the results suggested that there is no clear profile of core skills that can lead to mastering it. The results of this survey highlight the knowledge gaps and the learning priorities, providing a basis for future standardization and consensus.

Published
2023
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19. Localization Techniques for Non-Palpable Breast Lesions : Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4/iBRA-NET, NCT 05559411)

Author

Banys-Paluchowski, Maggie, Kühn, Thorsten, Masannat, Yazan, Rubio, Isabel, de Boniface, Jana, Ditsch, Nina, Karadeniz Cakmak, Güldeniz, Karakatsanis, Andreas, Dave, Rajiv, Hahn, Markus, Potter, Shelley, Kothari, Ashutosh, Gentilini, Oreste Davide, Gulluoglu, Bahadir M., Lux, Michael Patrick, Smidt, Marjolein, Weber, Walter Paul, Aktas Sezen, Bilge, Krawczyk, Natalia, Hartmann, Steffi, Di Micco, Rosa, Nietz, Sarah, Malherbe, Francois, Cabioglu, Neslihan, Canturk, Nuh Zafer, Gasparri, Maria Luisa, Murawa, Dawid, Harvey, James, Banys-Paluchowski, Maggie, Kühn, Thorsten, Masannat, Yazan, Rubio, Isabel, de Boniface, Jana, Ditsch, Nina, Karadeniz Cakmak, Güldeniz, Karakatsanis, Andreas, Dave, Rajiv, Hahn, Markus, Potter, Shelley, Kothari, Ashutosh, Gentilini, Oreste Davide, Gulluoglu, Bahadir M., Lux, Michael Patrick, Smidt, Marjolein, Weber, Walter Paul, Aktas Sezen, Bilge, Krawczyk, Natalia, Hartmann, Steffi, Di Micco, Rosa, Nietz, Sarah, Malherbe, Francois, Cabioglu, Neslihan, Canturk, Nuh Zafer, Gasparri, Maria Luisa, Murawa, Dawid, and Harvey, James

Abstract

Background: Surgical excision of a non-palpable breast lesion requires a localization step. Among available techniques, wire-guided localization (WGL) is most commonly used. Other techniques (radioactive, magnetic, radar or radiofrequency-based, and intraoperative ultrasound) have been developed in the last two decades with the aim of improving outcomes and logistics. Methods: We performed a systematic review on localization techniques for non-palpable breast cancer. Results: For most techniques, oncological outcomes such as lesion identification and clear margin rate seem either comparable with or better than for WGL, but evidence is limited to small cohort studies for some of the devices. Intraoperative ultrasound is associated with significantly higher negative margin rates in meta-analyses of randomized clinical trials (RCTs). Radioactive techniques were studied in several RCTs and are non-inferior to WGL. Smaller studies show higher patient preference towards wire-free localization, but little is known about surgeons’ and radiologists’ attitudes towards these techniques. Conclusions: Large studies with an additional focus on patient, surgeon, and radiologist preference are necessary. This review aims to present the rationale for the MELODY (NCT05559411) study and to enable standardization of outcome measures for future studies. Simple summary Most breast cancers are small and can be treated using breast-conserving surgery. Since these tumors are non-palpable, they require a localization step that helps the surgeon to decide which tissue needs to be removed. The oldest localization technique is a guidewire placed into the tumor before surgery, usually using ultrasound or mammography. Afterwards, the surgeon removes the tissue around the wire tip. However, this technique has several disadvantages: It can cause the patient discomfort, requires a radiologist or another professional specialized in breast diagnostics to perform the procedure shortly before surgery, a

Published
2023
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20. Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions)

Author

Pathologie, Cancer, Elfgen, Constanze, Leo, Cornelia, Kubik-Huch, Rahel A., Muenst, Simone, Schmidt, Noemi, Quinn, Cecily, McNally, Sorcha, van Diest, Paul J., Mann, Ritse M., Bago-Horvath, Zsuzsanna, Bernathova, Maria, Regitnig, Peter, Fuchsjäger, Michael, Schwegler-Guggemos, Daniela, Maranta, Martina, Zehbe, Sabine, Tausch, Christoph, Güth, Uwe, Fallenberg, Eva Maria, Schrading, Simone, Kothari, Ashutosh, Sonnenschein, Martin, Kampmann, Gert, Kulka, Janina, Tille, Jean Christophe, Körner, Meike, Decker, Thomas, Lax, Sigurd F., Daniaux, Martin, Bjelic-Radisic, Vesna, Kacerovsky-Strobl, Stephanie, Condorelli, Rosaria, Gnant, Michael, Varga, Zsuzsanna, Pathologie, Cancer, Elfgen, Constanze, Leo, Cornelia, Kubik-Huch, Rahel A., Muenst, Simone, Schmidt, Noemi, Quinn, Cecily, McNally, Sorcha, van Diest, Paul J., Mann, Ritse M., Bago-Horvath, Zsuzsanna, Bernathova, Maria, Regitnig, Peter, Fuchsjäger, Michael, Schwegler-Guggemos, Daniela, Maranta, Martina, Zehbe, Sabine, Tausch, Christoph, Güth, Uwe, Fallenberg, Eva Maria, Schrading, Simone, Kothari, Ashutosh, Sonnenschein, Martin, Kampmann, Gert, Kulka, Janina, Tille, Jean Christophe, Körner, Meike, Decker, Thomas, Lax, Sigurd F., Daniaux, Martin, Bjelic-Radisic, Vesna, Kacerovsky-Strobl, Stephanie, Condorelli, Rosaria, Gnant, Michael, and Varga, Zsuzsanna

Published
2023

21. Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions)

Author

Elfgen, Constanze; https://orcid.org/0000-0001-6092-6612, Leo, Cornelia; https://orcid.org/0000-0003-1601-0281, Kubik-Huch, Rahel A; https://orcid.org/0000-0002-3636-8697, Muenst, Simone, Schmidt, Noemi, Quinn, Cecily, McNally, Sorcha, van Diest, Paul J, Mann, Ritse M, Bago-Horvath, Zsuzsanna; https://orcid.org/0000-0002-8555-7806, Bernathova, Maria, Regitnig, Peter, Fuchsjäger, Michael, Schwegler-Guggemos, Daniela, Maranta, Martina, Zehbe, Sabine, Tausch, Christoph, Güth, Uwe; https://orcid.org/0000-0002-1849-5131, Fallenberg, Eva Maria, Schrading, Simone, Kothari, Ashutosh, Sonnenschein, Martin, Kampmann, Gert, Kulka, Janina, Tille, Jean-Christoph, Körner, Meike, Decker, Thomas, Lax, Sigurd F, Daniaux, Martin, Varga, Zsuzsanna; https://orcid.org/0000-0002-2855-983X, et al, Elfgen, Constanze; https://orcid.org/0000-0001-6092-6612, Leo, Cornelia; https://orcid.org/0000-0003-1601-0281, Kubik-Huch, Rahel A; https://orcid.org/0000-0002-3636-8697, Muenst, Simone, Schmidt, Noemi, Quinn, Cecily, McNally, Sorcha, van Diest, Paul J, Mann, Ritse M, Bago-Horvath, Zsuzsanna; https://orcid.org/0000-0002-8555-7806, Bernathova, Maria, Regitnig, Peter, Fuchsjäger, Michael, Schwegler-Guggemos, Daniela, Maranta, Martina, Zehbe, Sabine, Tausch, Christoph, Güth, Uwe; https://orcid.org/0000-0002-1849-5131, Fallenberg, Eva Maria, Schrading, Simone, Kothari, Ashutosh, Sonnenschein, Martin, Kampmann, Gert, Kulka, Janina, Tille, Jean-Christoph, Körner, Meike, Decker, Thomas, Lax, Sigurd F, Daniaux, Martin, Varga, Zsuzsanna; https://orcid.org/0000-0002-2855-983X, and et al

Abstract

The heterogeneous group of B3 lesions in the breast harbors lesions with different malignant potential and progression risk. As several studies about B3 lesions have been published since the last Consensus in 2018, the 3rd International Consensus Conference discussed the six most relevant B3 lesions (atypical ductal hyperplasia (ADH), flat epithelial atypia (FEA), classical lobular neoplasia (LN), radial scar (RS), papillary lesions (PL) without atypia, and phyllodes tumors (PT)) and made recommendations for diagnostic and therapeutic approaches. Following a presentation of current data of each B3 lesion, the international and interdisciplinary panel of 33 specialists and key opinion leaders voted on the recommendations for further management after core-needle biopsy (CNB) and vacuum-assisted biopsy (VAB). In case of B3 lesion diagnosis on CNB, OE was recommended in ADH and PT, whereas in the other B3 lesions, vacuum-assisted excision was considered an equivalent alternative to OE. In ADH, most panelists (76%) recommended an open excision (OE) after diagnosis on VAB, whereas observation after a complete VAB-removal on imaging was accepted by 34%. In LN, the majority of the panel (90%) preferred observation following complete VAB-removal. Results were similar in RS (82%), PL (100%), and FEA (100%). In benign PT, a slim majority (55%) also recommended an observation after a complete VAB-removal. VAB with subsequent active surveillance can replace an open surgical intervention for most B3 lesions (RS, FEA, PL, PT, and LN). Compared to previous recommendations, there is an increasing trend to a de-escalating strategy in classical LN. Due to the higher risk of upgrade into malignancy, OE remains the preferred approach after the diagnosis of ADH.

Published
2023

23. Localization Techniques for Non-Palpable Breast Lesions: Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4/iBRA-NET, NCT 05559411)

Author

Banys-Paluchowski, Maggie, primary, Kühn, Thorsten, additional, Masannat, Yazan, additional, Rubio, Isabel, additional, de Boniface, Jana, additional, Ditsch, Nina, additional, Karadeniz Cakmak, Güldeniz, additional, Karakatsanis, Andreas, additional, Dave, Rajiv, additional, Hahn, Markus, additional, Potter, Shelley, additional, Kothari, Ashutosh, additional, Gentilini, Oreste Davide, additional, Gulluoglu, Bahadir M., additional, Lux, Michael Patrick, additional, Smidt, Marjolein, additional, Weber, Walter Paul, additional, Aktas Sezen, Bilge, additional, Krawczyk, Natalia, additional, Hartmann, Steffi, additional, Di Micco, Rosa, additional, Nietz, Sarah, additional, Malherbe, Francois, additional, Cabioglu, Neslihan, additional, Canturk, Nuh Zafer, additional, Gasparri, Maria Luisa, additional, Murawa, Dawid, additional, and Harvey, James, additional

Published
2023
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27. Sentinel lymph node biopsy in breast cancer: Why, how, when and new frontiers—July webinar update, recap and takeaways

Author

Kothari, Ashutosh, primary, Joshi, Sneha, additional, Mishra, Rupa, additional, John, Jisha, additional, Knauer, Michael, additional, Karakatsanis, Andreas, additional, Masannat, Yazan, additional, Wei Mok, Chi, additional, Kovács, Tibor, additional, Gulluoglu, Bahadir, additional, Varghese, Beenu, additional, and Jain, Urvashi, additional

Published
2023
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32. Methodological optimisation of intraoperative margin assessment using confocal microscopy

Author

Holford, Nicholas, primary, Jurrius, Patriek, additional, Boland, Michael, additional, Jain, Urvashi, additional, Ezzat, Ahmed, additional, Kothari, Ashutosh, additional, Vyas, Kushi, additional, Shifa, Belul, additional, Rosekilly, James, additional, Gillett, Cheryl, additional, Ramakrishnan, Rathi, additional, Pinder, Sarah, additional, Leff, Daniel, additional, and Purushotham, Arnie, additional

Published
2022
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33. Sentinel Node Biopsy Using a Magnetic Tracer Versus Standard Technique: The SentiMAG Multicentre Trial

Author

Douek, Michael, Klaase, Joost, Monypenny, Ian, Kothari, Ashutosh, Zechmeister, Katalin, Brown, Douglas, Wyld, Lynda, Drew, Philip, Garmo, Hans, Agbaje, Olorunsola, Pankhurst, Quentin, Anninga, Bauke, Grootendorst, Maarten, ten Haken, Bennie, Hall-Craggs, Margaret A., Purushotham, Arnie, Pinder, Sarah, and On behalf of the SentiMAG Trialists Group

Published
2014
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39. Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK ‘Alert Level 4’ phase of the B-MaP-C study

Author

Dave, Rajiv V., Kim, Baek, Courtney, Alona, O’Connell, Rachel, Rattay, Tim, Taxiarchi, Vicky P., Kirkham, Jamie J., Camacho, Elizabeth M., Fairbrother, Patricia, Sharma, Nisha, Cartlidge, Christopher W. J., Horgan, Kieran, McIntosh, Stuart A., Leff, Daniel R., Vidya, Raghavan, Holcombe, Chris, Copson, Ellen, Coles, Charlotte E., Cutress, Ramsey I., Gandhi, Ashu, Kirwan, Cliona C., Agrawal, Amit, Benson, John, Forouhi, Parto, Wignarajah, Primeera, Shrotri, Anu, Kattakayam, Arjun, Noronha, Jarin Louis, Martin, Lee, Lafi, Mohamed, Hardy, Rob, Amin, Khalid, AL-Zawi, Abdalla Saad Abdalla, Elamass, Mohamed, Salih, Ali, Alkistawi, Firas Eddin Bachir, Heeney, Anna, Hill, Arnold D. K., Power, Colm, Allen, Michael J., Chouhan, Ashok, Rathinaezhil, Rathi, Shaheed, Samy, Zammit, Charles, Clayton, Gillian, Dua, Sascha, Smith, Simon, Gandamihardja, Tasha, Williams, Chloe, Egbeare, Donna, Davies, Eleri, Sweetland, Helen M., Chopra, Sharat, Goyal, Sumit, Elfadl, Dalia, Rana, Dheer Singh, Kalakouti, Eliana, Barkeji, Musa, Vashisht, Rajiv, Bunza, Ralia, Phyu, Saung Hnin, Hollywood, Ciaran, Azmy, Iman, Massey, Julia, Hargreaves, Anita, Harding-Mackean, Claudia, Ooi, Jane, Seward, Joanna, Mathers, Helen, Scally, Norah, Salman, Reem, Shin, Hyunjin, Turner, Jane, Noor, Lubna, Joshi, Sanjay, Horne, Sarah, Sarakbi, Wail Al, Liptay-Wagner, Peter, Jacklin, Rosamond, Chandrasekharan, Sankaran, Marsh, Simon, Saha, Sunita, Wilson, Christopher, Rutherford, Claire Louise, Doughty, Julie, Romics, Laszlo, Stallard, Sheila, Chaudhry, Anushka, Peck, Jennifer, Coombs, Nathan, Williams, Samantha K., Hawkins, Simon, Kothari, Ashutosh, Hamed, Hisham, Jain, Urvashi, Daltrey, Ian, Abbott, Nick, Mullen, Russell, Dumitru, Dorin, Khalifa, Eiman, Sarker, Masuma, Elahi, M. Bilal, Bichoo, Raouef Ahmed, Gvaramadze, Anzors, Thekkinkattil, Dinesh, Jibril, Jibril, Hadjiminas, Demetrios, St John, Edward R. C., Robb, Henry Douglas, Hogben, Katy, Bakri, Nur Amalina Che, Thiruchelvam, Paul, Exarchos, Georgios, Al-Mufti, Ragheed, Mortimer, Caroline, Mallidis, Evangelos, Karagiannidis, Georgios, Tuffaha, Hussein, Peerlink, Inga, Nair, Rajive, Prusty, Lydia, Sami, Amtul, Knight, Alex, Ravichandran, Duraisamy, Kirkpatrick, Katharine, James, Ruth, Akolekar, Deepika, Mehta, Disha, Barua, Ellora, Knowles, Hannah, Devalia, Haresh, Cox, Karina, Dani, Mohsin, Chalmers, Ritchie, Satpathy, Anjana, Quinn, Edel, Byrne, Gerard, Harvey, James, Murphy, John, Highton, Lyndsey, Sharif, Mohammad Amir, Barnes, Nicola, Dimopoulos, Nikitas, Johnson, Richard, Chatterjee, Sumohan, Fatayer, Hiba, Mathen, Vinod, Taylor, Amanda, Soulsby, Rachel, Walsh, Adam, Thorne, Amanda, Gill, Jasper, Merker, Louise, Critchley, Adam, Pieri, Andrew, Cain, Henry, Ralph, Jane, Kalra, Loraine, Thomas, Robert, Young, Ian, Khan, Lucy R., Elsberger, Beatrix, Smyth, Elizabeth, Urquhart, Gordon, Fuller, Mairi, Masannat, Yazan, Chrysafi, Ada, Salman, Muhammad, Abdalla, El-Rasheed, Zechmeister, Katalin, Hussien, Maged, Youssef, Mina M. G., Tanhueco, Angeline, Salvador, Reginald, Wallace, Sharon, Pain, Simon, Sahu, Ajay, Chambers, Alice, Moody, Alice, Dash, Isabella, Cook, James, Batt, Jeremy, Mullan, Michelle, Shere, Mike, Gallegos, Nicholas, Ainsworth, Rachel, Govindarajulu, Sasi, Potter, Shelley, Rayter, Zenon, Williams, Kate E., Bramley, Maria, Absar, Mohammed, Nasir, Nabila, Tabbakh, Rami, Pereira, Bernadette, Gahir, Jasdeep, Bosch, Karen, Fafemi, Oladapo, Touqan, Nader, Oni, Georgette, Khout, Hazem, Asgeirsson, Kristjan, Whisker, Lisa, Lee, Rachel Xue Ning, Macmillan, Robert, McCulley, Stephen, Rasheed, Tuabin, Adwani, Asha, Segaran, Ashvina, Dodwell, David, Remoundos, Dennis, MacLean, Gael, Cuffolo, Giulio, Douek, Michael, Roy, Pankaj, Gathani, Toral, Najeeb, Erum, Simonca, Claudiu, Verroiotou, Maria, Ramzi, Sa’ed, Jenkins, Stephanie C., Gopalan, Vallipuran, Barker, Sarah, McGoldrick, Ciara, Irwin, Gareth W., Mallon, Peter, Sloan, Samantha A., Imran, Abbas, Mondani, Giuseppina, Brown, Iain, Abbas, Imran, Sulieman, Mona, Drew, Philip, King, Polly, English, Rachel Elizabeth, Sharma, Anita, Ives, Charlotte, Ferguson, Douglas, Boundouki, George, Bentley, James, Banks, Jenny, Dunn, Julie, Tillett, Rachel, Olsen, Sisse, Tansley, Anne, Sousa, Emma De, Mitchell, Geraldine, Whitehead, Ian, Henderson, Julia, Rowland, Matthew, Chandrashekar, Mysore, Eid, Raja, Clayton, Elizabeth, Pakzad, Farrokh, Horsnell, Jonathan D., Hague, Matthew, Partlett, Polly, Irvine, Tracey, Kallaway, Charlotte, Fairhurst, Katherine, Laban, Christiana, McIntosh, Jamie, Laurence, Nicola, Sutton, Richard, Sharma, Anup, Banerjee, Dibyesh, Betambeau, Nadine, Bezzaa, Sabrina, Bathla, Sonia, Ray, Atanu, Chagla, Leena, Kiernan, Tamara, Hogan, Brian, Navin, Channegowda, Macinnes, Emma, Turton, Philip, Achuthan, Raj, Kantola, Venla, Mckenzie, Shireen, Dent, Helen, Pogson, Caroline, Waheed, Shamaela, De Silva, Tania S., Suleiman, Usama, Jones, Lucie, Athwal, Ruvinder, Harries, Simon, Krzyzanowska, Catherine, Abbas, Abeera, Hurley, Anna R., Gui, Gerald, Rusby, Jennifer E., Krupa, Katherine, Harborough, Kathryn E., Roche, Nicola, Barry, Peter A., Law, Rebekah, Allum, William H., Lobo, Cheryl, Ntakomyti, Eleni, Franks, Joanna, Cariati, Massimiliano, Patani, Neill, Stanilov, Noyko, Charalampoudis, Petros, Taraki, Zarghuna, McEvoy, Kat, Sait, Mohamed Razick, Robertson, Stuart, Zeidan, Bashar, Rew, David, Mazari, Fayyaz, Alder, Louise, Sakellariou, Vasileios, Hamad, Ahmed, Goyal, Amit, Carmichael, Amtul, Courtney, Carol-Ann, Sibbering, David Mark, Garreffa, Emanuele, Cheung, Kwok-Leung, Williams-Jones, Susan, Wahedna, Yasmin, Ansari, Aonghus, Kenny, Frances, Valassiadou, Kalliope, Lambert, Kelly, Krupa, Jaroslaw, Sardar, Mini V., Kaushik, Monika, Shokuhi, Sheila, Pilgrm, Simon, Sasi, Walid, McManus, Penelope, Parmeshwar, Rishikesh, Somasundaram, Santosh, Gowda, Manoj, Jafferbhoy, Sadaf, Narayanan, Sankaran, Marla, Sekhar, Soumian, Soni, Goh, Ngee-Ming, Vatish, Jamie, Sein, Tin Aung, Agabiti, Ennio, Maalo, Joseph, Chong, Kelvin, Lai, Lee-Min, Elkorety, Mohamed, Monib, Sherif, Thomson, Simon, Mikhael, Youhana, Mirshekar-Syahkal, Bahar, Aitken, Jane, Girgis, Mina, Betal, Dibendu, Rapisarda, Fabio, Cook, Lorna, Odofin, Olubunmi, Bonomi, Riccardo, Wardle, Stacy, Sotheran, Wendy, Athanasiou, Irene, Lund, Jonathan, Callaghan, Maria, Burrah, Rajaram, Vinayagam, Raman, James, Karen, Poonawala, Shabbir, Isgar, Brian, Matey, Pilar, Mylvaganam, Senthurun, Podesta, Carl, Sircar, Tapan, Salem, Fathi, Al-Ishaq, Zaid, Dave, Rajiv V. [0000-0001-6827-8090], McIntosh, Stuart A. [0000-0002-4123-9611], Potter, Shelley [0000-0002-6977-312X], Copson, Ellen [0000-0001-8994-4056], and Apollo - University of Cambridge Repository

Subjects
692/700/784, article, 692/4028/67/1347, 692/700/3934, 692/700/1538, 692/4028/546
Abstract

Background: The B-MaP-C study aimed to determine alterations to breast cancer (BC) management during the peak transmission period of the UK COVID-19 pandemic and the potential impact of these treatment decisions. Methods: This was a national cohort study of patients with early BC undergoing multidisciplinary team (MDT)-guided treatment recommendations during the pandemic, designated ‘standard’ or ‘COVID-altered’, in the preoperative, operative and post-operative setting. Findings: Of 3776 patients (from 64 UK units) in the study, 2246 (59%) had ‘COVID-altered’ management. ‘Bridging’ endocrine therapy was used (n = 951) where theatre capacity was reduced. There was increasing access to COVID-19 low-risk theatres during the study period (59%). In line with national guidance, immediate breast reconstruction was avoided (n = 299). Where adjuvant chemotherapy was omitted (n = 81), the median benefit was only 3% (IQR 2–9%) using ‘NHS Predict’. There was the rapid adoption of new evidence-based hypofractionated radiotherapy (n = 781, from 46 units). Only 14 patients (1%) tested positive for SARS-CoV-2 during their treatment journey. Conclusions: The majority of ‘COVID-altered’ management decisions were largely in line with pre-COVID evidence-based guidelines, implying that breast cancer survival outcomes are unlikely to be negatively impacted by the pandemic. However, in this study, the potential impact of delays to BC presentation or diagnosis remains unknown.

Published
2021
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41. Additional file 3 of Intraoperative [18F]FDG flexible autoradiography for tumour margin assessment in breast-conserving surgery: a first-in-human multicentre feasibility study

Author

Jurrius, Patriek A. G. T., Grootendorst, Maarten R., Krotewicz, Marika, Cariati, Massimiliano, Kothari, Ashutosh, Patani, Neill, Karcz, Paulina, Nagadowska, Monika, Vyas, Kunal N., Purushotham, Arnie, and Turska-D’Amico, Maria

Abstract

Additional file 3: Table 2. Confusion matrix of FAR imaging for intraoperative margin assessment of intact WLE specimens compared to gold standard histopathology. The patients were divided into three subgroups based on T-classification.

Published
2021
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42. Additional file 2 of Intraoperative [18F]FDG flexible autoradiography for tumour margin assessment in breast-conserving surgery: a first-in-human multicentre feasibility study

Author

Jurrius, Patriek A. G. T., Grootendorst, Maarten R., Krotewicz, Marika, Cariati, Massimiliano, Kothari, Ashutosh, Patani, Neill, Karcz, Paulina, Nagadowska, Monika, Vyas, Kunal N., Purushotham, Arnie, and Turska-D’Amico, Maria

Abstract

Additional file 2: Table 1. Confusion matrix of FAR imaging for intraoperative margin assessment of intact WLE specimens compared to gold standard histopathology. The patients were divided into two subgroups based on the time between [18F]FDG injection and intraoperative FAR imaging (threshold: 158 min). The mean injection to imaging times between the two subgroups was not statistically significant (p

Published
2021
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44. SKIN AND NIPPLE NECROSIS RATES WHEN USING INFRAMAMMARY FOLD APPROACH FOR NIPPLE SPARING MASTECTOMY – A 5-YEAR SINGLE CENTRE RETROSPECTIVE STUDY.

Author

Mimoso, Ana, Malik, Mariam, Kothari, Ashutosh, and Hamed, Hisham

Subjects
MASTECTOMY, MAMMAPLASTY
Abstract

Background: Nipple-sparing mastectomy (NSM) followed by immediate breast reconstruction (IR) has become standard of care when feasible and oncologically safe. Nipple areola complex (NAC) and skin ischaemia / necrosis, is a major complication following NSM, leading to adverse aesthetic outcomes, infection and on occasion loss of an implant based immediate breast reconstruction. Several studies have identified the type of surgical incision as one of the risk factors of ischaemic complications. Amongst the most common incisions preferred are the; radial, periareolar and inframammary approaches. Methods: At a tertiary large volume academic centre in London, we designed a retrospective study to analyse our immediate skin envelope related ischaemic complications using an inframammary incision for NSM and immediate implant based single stage breast reconstruction. For this we used Guy’s and St. Thomas Hospital electronic patient records from 2019 to 2023. Results: Our study is ongoing and we aim to have the data in time for the conference. We estimate a low incidence rate of ischaemic and necrotic complications with our favoured inframammary fold approach. Conclusion: Based on our 5-year post-operative outcomes, we suggest the inframammary incision choice is oncologically safe with minimal impact to the NAC and flap viability. [ABSTRACT FROM AUTHOR]

Published
2024

45. OPPORTUNISTIC SCREENING MAMMOGRAPHY IN WOMEN OVER 40 ATTENDING THE ONE STOP BREAST CLINIC IN THE UK. IS IT TIME FOR A CHANGE IN RECOMMENDATIONS OR GUIDELINES?

Author

Chougle, Qurratulain Ali, Mimoso, Ana, Kalyvioti, Christina, Hamed, Hisham, and Kothari, Ashutosh

Subjects
MAMMOGRAMS, EARLY detection of cancer, BREAST cancer
Abstract

Background: Breast cancer is the most frequently diagnosed cause of death from cancer in women worldwide. Largely due to delayed presentation it is the leading cause of death from cancer in low- and middle-income countries. Population based breast screening programmes aim to reduce mortality, as well as treatment induced morbidity, through early detection. To date, these programmes are targeted at women purely based on age and are not risk stratified. Due to increased awareness, symptomatic breast clinics are inundated with women that are referred with a variety of breast symptoms. Most of these women do not have any clinical signs, and the examination is normal, however, again based on age these “worried well” women are offered mammograms based on local, regional and national guidelines. This population forms a cohort of women that are offered opportunistic breast screening despite a normal physical examination. There is limited data on whether these opportunistic screeners have the same or indeed any benefit as the population based screening cohort. Methods: At a busy tertiary referral academic breast unit seeing close to 200 symptomatic women a week, we designed a retrospective study to look at number of cancers detected in symptomatic women with a normal physical examination. Using electronic patient hospital records, we aim to look at the mammogram reports of all women referred between June 2023 to September 2023, with a normal clinical examination. Results: The study is in progress and we aim to have the data in time for the conference. We speculate that the number of “incidental” breast cancer diagnosis in this cohort of women will be very low. Conclusion: Based on our results we could be in a position to inform societies and health care policy makers on the benefit of opportunistic screening and whether it makes economic sense to continue. [ABSTRACT FROM AUTHOR]

Published
2024

46. Abstract PS8-22: Augmentation of a minimal multidisciplinary tumor board with clinical decision support to triage breast cancer patients in the UK

Author

Kristeleit, Hartmut, primary, Martin, Martha, additional, Karampera, Christina, additional, Hekmat, Rezzan, additional, IntHout, Bertha, additional, Kothari, Ashutosh, additional, Kazmi, Majid, additional, Clery, Amanda, additional, Wang, Yanzhong, additional, Coker, Bolaji, additional, Felix, Winnie, additional, Preininger, Anita, additional, Wang, Suwei, additional, Vergis, Roy, additional, Eggebraaten, Tom, additional, Gloe, Christopher, additional, Dankwa-Mullan, Irene, additional, Jackson, Gretchen, additional, Rigg, Anna, additional, and Ruta, Danny, additional

Published
2021
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47. Intraoperative [18F]FDG&nbsp; flexible autoradiography for tumour margin assessment in breast-conserving surgery – a first-in-human multicentre feasibility study

Author

Jurrius, Patriek A.G.T., primary, Grootendorst, Maarten R, additional, Krotewicz, Marika, additional, Cariati, Massimiliano, additional, Kothari, Ashutosh, additional, Patani, Neill, additional, Karcz, Paulina Patrycja, additional, Nagadowska, Monika, additional, Vyas, Kunal N, additional, Purushotham, Arnie, additional, and Turska-d'Amico, Maria, additional

Published
2021
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