1. [Mesenchymal stem cells transplantation in the treatment of radiation skin lesions].
- Author
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Kotenko KB, Moroz BB, Nadezhina NM, Galstian IA, Onishchenko NA, Eremin II, Deshevoĭ IuB, Lebedev VG, Slobodina TS, Dubitskiĭ SE, Grinakovskaia OS, Zhgutov IuA, and Bushmanov AIu
- Subjects
- Aged, Animals, Female, Gamma Rays adverse effects, Humans, Male, Middle Aged, Radiation Injuries, Experimental pathology, Radiodermatitis pathology, Rats, Rats, Wistar, Skin pathology, Transplantation, Autologous, Mesenchymal Stem Cell Transplantation, Radiation Injuries, Experimental therapy, Radiodermatitis therapy, Skin injuries
- Abstract
Transplantation of mesenchymal stem cells, both at early and later stage after local exposure of rats source beta radiation dose, 90Sr/90Y 140 GR, stimulates recovery of damaged skin. Diminution area local radiation injuries and accelerate healing radiation ulcers. Clinically shows the high efficiency of the transplantations autologous mesenchymal stem cells in treatment of deep beam ulcers, intractable standard conservative treatment. Found promising application of mesenchymal stem cells for treatment of severe local radiation injuries and the need to develop the best possible conditions for their use. more...
- Published
- 2011