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Your search keyword '"Kostrykina, V. N."' showing total 10 results
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10 results on '"Kostrykina, V. N."'

7. [Inhibition of the growth of the Ca-755 tumor in mice with reconstitution of hematopoiesis].

Author

Chimishkian KL, Kostrykina VN, and Ovumian GSh

Subjects
Animals, Female, Liver embryology, Male, Mammary Neoplasms, Experimental physiopathology, Mice, Neoplasm Transplantation, Pregnancy, Bone Marrow Transplantation, Hematopoiesis, Liver Transplantation, Mammary Neoplasms, Experimental therapy
Abstract

Data on the growth inhibition of Ca-755 tumor transplanted to mice two months after hemopoiesis recovery with syngeneic bone marrow cells or allogeneic fetal liver are presented.

Published
1988

9. [ICO-10 monoclonal antibodies to the Thy-1 antigen].

Author

Korotkova OV, Baryshnikov AIu, Tupitsyn NN, Chimishkian KL, and Kostrykina VN

Subjects
Adolescent, Animals, Antibodies, Monoclonal analysis, Antigen-Antibody Reactions, Blood Cells immunology, Bone Marrow immunology, Child, Child, Preschool, Humans, Immunization, Infant, Leukemia immunology, Lymphoma, Non-Hodgkin immunology, Mice, Species Specificity, Thy-1 Antigens, Thymus Gland immunology, Antibodies, Monoclonal isolation & purification, Antigens, Surface immunology
Abstract

Mouse monoclonal antibodies (MAB) ICO-10 to Thy-1 antigen were obtained. MAB ICO-10 reacted in indirect immunofluorescence test with 5.7 +/- 0.8% human thymocytes. Antibodies did not react with granulocytes, monocytes, T- and non-T cells from peripheral blood, and with marrow cells of healthy donors. MAB ICO-10 reacted with blast cells from 25 of 53 patients with T-cell acute lymphoblastic leukemia (ALL), from 2 of 5 patients with B-cell ALL. This antigen was absent on blood and marrow cells from some patients with ALL, 80 patients with chronic lymphoid leukemia, 54 patients with chronic granulocytic leukemia at the stage of blastic crisis, 128 patients with acute nonlymphoblastic leukemia. Antibodies are specifically bound to thymocytes and spleen cells of Thy 1.1 and Thy 1.2 mice. MAB ICO-10 detect Thy-1 antigen expressed on human hematopoietic cells. MAB ICO-10 may be applied for human leukemia and lymphoma immune diagnosis.

Published
1989

10. [Modeling of the "universal" bone marrow using monoclonal antibodies].

Author

Chimishkian KL, Baryshnikov AIu, Ovumian GSh, Kostrykina VN, Karpov IA, Buntsevich AM, Slavina EG, Udalov GA, and Kadagidze ZG

Subjects
Animals, Complement System Proteins therapeutic use, Graft vs Host Reaction, Lymphocyte Culture Test, Mixed, Male, Mice, Mice, Inbred BALB C, Rabbits, Spleen cytology, Spleen immunology, T-Lymphocytes immunology, Antibodies, Monoclonal therapeutic use, Bone Marrow Transplantation
Abstract

The data on the application of monoclonal antibodies (ICO-10) and rabbit complement for working the conditions of allogeneic bone marrow transplantation are presented in the paper. The treatment with monoclonal antibodies and bone marrow complement from BALB/c mice for 2 times prevented the development of transplant versus host reaction and completely protected lethally irradiated (CBA X X C57B1/6)FI mice-recipients from death. Thymus atrophy and the absence of T-cells in the peripheral blood was observed in these mice. The erythrocytes had markers characteristic of BALB/c and (CBA X C57B1/6)FI mice. Mouse splenocytes did not respond to the cells of donors and recipients in mixed lymphocyte culture reaction.

Published
1989

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