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20. Chemokine receptor–targeted PET/CT provides superior diagnostic performance in newly diagnosed marginal zone lymphoma patients: a head-to-head comparison with [18F]FDG

Author

Kosmala, Aleksander, primary, Duell, Johannes, additional, Schneid, Simone, additional, Serfling, Sebastian E., additional, Higuchi, Takahiro, additional, Weich, Alexander, additional, Lapa, Constantin, additional, Hartrampf, Philipp E., additional, Raderer, Markus, additional, Einsele, Hermann, additional, Buck, Andreas K., additional, Topp, Max S., additional, Schlötelburg, Wiebke, additional, and Werner, Rudolf A., additional

Published
2023
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22. Chemokine Receptor PET/CT Provides Relevant Staging and Management Changes in Marginal Zone Lymphoma

Author

Duell, Johannes, primary, Buck, Andreas K., additional, Hartrampf, Philipp E., additional, Schlötelburg, Wiebke, additional, Schneid, Simone, additional, Weich, Alexander, additional, Dreher, Niklas, additional, Lapa, Constantin, additional, Kircher, Malte, additional, Higuchi, Takahiro, additional, Samnick, Samuel, additional, Serfling, Sebastian E., additional, Raderer, Markus, additional, Rasche, Leo, additional, Einsele, Hermann, additional, Topp, Max S., additional, Kosmala, Aleksander, additional, and Werner, Rudolf A., additional

Published
2023
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26. Chemokine receptor–targeted PET/CT provides superior diagnostic performance in newly diagnosed marginal zone lymphoma patients: a head-to-head comparison with [18F]FDG.

Author

Kosmala, Aleksander, Duell, Johannes, Schneid, Simone, Serfling, Sebastian E., Higuchi, Takahiro, Weich, Alexander, Lapa, Constantin, Hartrampf, Philipp E., Raderer, Markus, Einsele, Hermann, Buck, Andreas K., Topp, Max S., Schlötelburg, Wiebke, and Werner, Rudolf A.

Subjects
*MUCOSA-associated lymphoid tissue lymphoma, *POSITRON emission tomography, *CHEMOKINE receptors, *CXCR4 receptors
Abstract

Background: In patients with marginal zone lymphoma (MZL), [18F]FDG PET/CT provided inconsistent diagnostic accuracy. C-X-C motif chemokine receptor 4 (CXCR4) is overexpressed in MZL and thus, may emerge as novel theranostic target. We aimed to evaluate the diagnostic performance of CXCR4-targeting [68Ga]Ga-PentixaFor when compared to [18F]FDG PET/CT in MZL. Methods: Thirty-two untreated MZL patients (nodal, n = 17; extranodal, n = 13; splenic, n = 2) received [68Ga]Ga-PentixaFor and [18F]FDG PET/CT within median 2 days. We performed a visual and quantitative analysis of the total lymphoma volume by measuring maximum/peak standardized uptake values (SUVmax/peak), and calculating target-to-background ratios (TBR, defined as lesion-based SUVpeak divided by SUVmean from blood pool). Visual comparisons for both radiotracers were carried out for all target lesions (TL), and quantitative analysis of concordant TL evident on both scans. Last, MZL subtype analyses were also conducted. Results: On a patient-based level, [68Ga]Ga-PentixaFor identified MZL manifestations in 32 (100%) subjects (vs. [18F]FDG, 25/32 [78.1%]). Of the 256 identified TL, 127/256 (49.6%) manifestations were evident only on CXCR4-directed imaging, while only 7/256 (2.7%) were identified on [18F]FDG but missed by [68Ga]Ga-PentixaFor. In the remaining 122/256 (47.7%) concordant TL, [68Ga]Ga-PentixaFor consistently provided increased metrics when compared to [18F]FDG: SUVmax, 10.3 (range, 2.53–37.2) vs. 5.72 (2.32–37.0); SUVpeak, 6.23 (1.58–25.7) vs. 3.87 (1.54–27.7); P < 0.01, respectively. Concordant TL TBR on [68Ga]Ga-PentixaFor (median, 3.85; range, 1.05–16.0) was also approximately 1.8-fold higher relative to [18F]FDG (median, 2.08; range, 0.81–28.8; P < 0.01). Those findings on image contrast, however, were driven by nodal MZL (P < 0.01), and just missed significance for extranodal MZL (P = 0.06). Conclusions: In newly diagnosed MZL patients, [68Ga]Ga-PentixaFor identified more sites of disease when compared to [18F]FDG, irrespective of MZL subtype. Quantitative PET parameters including TBR were also higher on [68Ga]Ga-PentixaFor PET/CT, suggesting improved diagnostic read-out using chemokine receptor-targeted imaging. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Radiopharmaceuticals for Treatment of Adrenocortical Carcinoma.

Author

Michalski, Kerstin, Schlötelburg, Wiebke, Hartrampf, Philipp E., Kosmala, Aleksander, Buck, Andreas K., Hahner, Stefanie, and Schirbel, Andreas

Subjects
CHEMOKINE receptors, RADIOPHARMACEUTICALS, DRUG target, NUCLEAR medicine, CARCINOMA, CANCER invasiveness
Abstract

Adrenocortical carcinoma (ACC) represents a rare tumor entity with limited treatment options and usually rapid tumor progression in case of metastatic disease. As further treatment options are needed and ACC metastases are sensitive to external beam radiation, novel theranostic approaches could complement established therapeutic concepts. Recent developments focus on targeting adrenal cortex-specific enzymes like the theranostic twin [123/131I]IMAZA that shows a good image quality and a promising therapeutic effect in selected patients. But other established molecular targets in nuclear medicine such as the C-X-C motif chemokine receptor 4 (CXCR4) could possibly enhance the therapeutic regimen as well in a subgroup of patients. The aims of this review are to give an overview of innovative radiopharmaceuticals for the treatment of ACC and to present the different molecular targets, as well as to show future perspectives for further developments since a radiopharmaceutical with a broad application range is still warranted. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Test–retest repeatability of organ uptake on PSMA‐targeted 18F‐DCFPyL PET/CT in patients with prostate cancer

Author

Werner, Rudolf A., primary, Lütje, Susanne, additional, Habacha, Bilêl, additional, Bundschuh, Lena, additional, Higuchi, Takahiro, additional, Buck, Andreas K., additional, Kosmala, Aleksander, additional, Lapa, Constantin, additional, Essler, Markus, additional, Lodge, Martin A., additional, Pienta, Kenneth J., additional, Eisenberger, Mario A., additional, Markowski, Mark C., additional, Gorin, Michael A., additional, Pomper, Martin G., additional, Rowe, Steven P., additional, and Bundschuh, Ralph A., additional

Published
2023
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29. Ultra-high field cardiac MRI in large animals and humans for translational cardiovascular research

Author

Schreiber, Laura M., primary, Lohr, David, additional, Baltes, Steffen, additional, Vogel, Ulrich, additional, Elabyad, Ibrahim A., additional, Bille, Maya, additional, Reiter, Theresa, additional, Kosmala, Aleksander, additional, Gassenmaier, Tobias, additional, Stefanescu, Maria R., additional, Kollmann, Alena, additional, Aures, Julia, additional, Schnitter, Florian, additional, Pali, Mihaela, additional, Ueda, Yuichiro, additional, Williams, Tatiana, additional, Christa, Martin, additional, Hofmann, Ulrich, additional, Bauer, Wolfgang, additional, Gerull, Brenda, additional, Zernecke, Alma, additional, Ergün, Süleyman, additional, and Terekhov, Maxim, additional

Published
2023
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30. Interobserver Agreement Rates on C-X-C Motif Chemokine Receptor 4–Directed Molecular Imaging and Therapy

Author

Hartrampf, Philipp E., primary, Kosmala, Aleksander, additional, Serfling, Sebastian E., additional, Bundschuh, Lena, additional, Higuchi, Takahiro, additional, Lapa, Constantin, additional, Rowe, Steven P., additional, Matsusaka, Yohji, additional, Weich, Alexander, additional, Buck, Andreas K., additional, Bundschuh, Ralph A., additional, and Werner, Rudolf A., additional

Published
2023
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32. Wnt/β-catenin modulating drugs regulate somatostatin receptor expression and internalization of radiolabelled octreotide in neuroendocrine tumor cells

Author

Weich, Alexander, primary, Rogoll, Dorothea, additional, Peschka, Melissa, additional, Weich, Wolfgang, additional, Pongracz, Judit, additional, Brand, Markus, additional, Fröhlich, Matthias, additional, Serfling, Sebastian E., additional, Rowe, Steven P., additional, Kosmala, Aleksander, additional, Reiter, Florian P., additional, Meining, Alexander, additional, Werner, Rudolf A., additional, and Scheurlen, Michael, additional

Published
2023
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33. Impact of 68Ga-FAPI-04 PET/CT on Staging and Therapeutic Management in Patients With Digestive System Tumors

Author

Kosmala, Aleksander, primary, Serfling, Sebastian E., additional, Schlötelburg, Wiebke, additional, Lindner, Thomas, additional, Michalski, Kerstin, additional, Schirbel, Andreas, additional, Higuchi, Takahiro, additional, Hartrampf, Philipp E., additional, Buck, Andreas K., additional, Weich, Alexander, additional, and Werner, Rudolf A., additional

Published
2022
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34. Effects of image homogeneity on stenosis visualization at 7 T in a coronary artery phantom study: With and without B1-shimming and parallel transmission

Author

Herz, Stefan, primary, Stefanescu, Maria R., additional, Lohr, David, additional, Vogel, Patrick, additional, Kosmala, Aleksander, additional, Terekhov, Maxim, additional, Weng, Andreas M., additional, Grunz, Jan-Peter, additional, Bley, Thorsten A., additional, and Schreiber, Laura M., additional

Published
2022
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35. Associations between Normal Organs and Tumor Burden in Patients Imaged with Fibroblast Activation Protein Inhibitor-Directed Positron Emission Tomography

Author

Kosmala, Aleksander, primary, Serfling, Sebastian E., additional, Dreher, Niklas, additional, Lindner, Thomas, additional, Schirbel, Andreas, additional, Lapa, Constantin, additional, Higuchi, Takahiro, additional, Buck, Andreas K., additional, Weich, Alexander, additional, and Werner, Rudolf A., additional

Published
2022
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36. Combination of Iterative Metal Artifact Reduction and Virtual Monoenergetic Reconstruction Using Split-Filter Dual-Energy CT in Patients With Dental Artifact on Head and Neck CT

Author

Schmidt, Alexander Marcel Alfred, primary, Grunz, Jan-Peter, additional, Petritsch, Bernhard, additional, Gruschwitz, Philipp, additional, Knarr, Jonas, additional, Huflage, Henner, additional, Bley, Thorsten Alexander, additional, and Kosmala, Aleksander, additional

Published
2022
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39. Split-filter dual-energy CT pulmonary angiography for the diagnosis of acute pulmonary embolism: a study on image quality and radiation dose

Author

Petritsch, Bernhard, Pannbecker, Pauline, Weng, Andreas M., Grunz, Jan-Peter, Veldhoen, Simon, Bley, Thorsten A., and Kosmala, Aleksander

Subjects
Original Article, ddc:610
Abstract

Background: Computed tomography (CT) pulmonary angiography is the diagnostic reference standard in suspected pulmonary embolism (PE). Favorable results for dual-energy CT (DECT) images have been reported for this condition. Nowadays, dual-energy data acquisition is feasible with different technical options, including a single-source split-filter approach. Therefore, the aim of this retrospective study was to investigate image quality and radiation dose of thoracic split-filter DECT in comparison to conventional single-energy CT in patients with suspected PE. Methods: A total of 110 CT pulmonary angiographies were accomplished either as standard single-energy CT with automatic tube voltage selection (ATVS) (n=58), or as split-filter DECT (n=52). Objective [pulmonary artery CT attenuation, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR)] and subjective image quality [four-point Likert scale; three readers (R)] were compared among the two study groups. Size-specific dose estimates (SSDE), dose-length-product (DLP) and volume CT dose index (CTDIvol) were assessed for radiation dose analysis. Results: Split-filter DECT images yielded 67.7% higher SNR (27.0 vs. 16.1; P

Published
2021

42. Effects of image homogeneity on stenosis visualization at 7 T in a coronary artery phantom study: With and without B1-shimming and parallel transmission.

Author

Herz, Stefan, Stefanescu, Maria R., Lohr, David, Vogel, Patrick, Kosmala, Aleksander, Terekhov, Maxim, Weng, Andreas M., Grunz, Jan-Peter, Bley, Thorsten A., and Schreiber, Laura M.

Subjects
CORONARY artery stenosis, HOMOGENEITY, STENOSIS, MAGNETIC resonance imaging, CORONARY arteries, LIQUID dielectrics
Abstract

Background: To investigate the effects of B1-shimming and radiofrequency (RF) parallel transmission (pTX) on the visualization and quantification of the degree of stenosis in a coronary artery phantom using 7 Tesla (7 T) magnetic resonance imaging (MRI). Methods: Stenosis phantoms with different grades of stenosis (0%, 20%, 40%, 60%, 80%, and 100%; 5 mm inner vessel diameter) were produced using 3D printing (clear resin). Phantoms were imaged with four different concentrations of diluted Gd-DOTA representing established arterial concentrations after intravenous injection in humans. Samples were centrally positioned in a thorax phantom of 30 cm diameter filled with a custom-made liquid featuring dielectric properties of muscle tissue. MRI was performed on a 7 T whole-body system. 2D-gradient-echo sequences were acquired with an 8-channel transmit 16-channel receive (8 Tx / 16 Rx) cardiac array prototype coil with and without pTX mode. Measurements were compared to those obtained with identical scan parameters using a commercially available 1 Tx / 16 Rx single transmit coil (sTX). To assess reproducibility, measurements (n = 15) were repeated at different horizontal angles with respect to the B0-field. Results: B1-shimming and pTX markedly improved flip angle homogeneity across the thorax phantom yielding a distinctly increased signal-to-noise ratio (SNR) averaged over a whole slice relative to non-manipulated RF fields. Images without B1-shimming showed shading artifacts due to local B1+-field inhomogeneities, which hampered stenosis quantification in severe cases. In contrast, B1-shimming and pTX provided superior image homogeneity. Compared with a conventional sTX coil higher grade stenoses (60% and 80%) were graded significantly (p<0.01) more precise. Mild to moderate grade stenoses did not show significant differences. Overall, SNR was distinctly higher with B1-shimming and pTX than with the conventional sTX coil (inside the stenosis phantoms 14%, outside the phantoms 32%). Both full and half concentration (10.2 mM and 5.1 mM) of a conventional Gd-DOTA dose for humans were equally suitable for stenosis evaluation in this phantom study. Conclusions: B1-shimming and pTX at 7 T can distinctly improve image homogeneity and therefore provide considerably more accurate MR image analysis, which is beneficial for imaging of small vessel structures. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Twin robotic x-ray system in small bone and joint trauma: impact of cone-beam computed tomography on treatment decisions

Author

Grunz, Jan-Peter, primary, Pennig, Lenhard, additional, Fieber, Tabea, additional, Gietzen, Carsten Herbert, additional, Heidenreich, Julius Frederik, additional, Huflage, Henner, additional, Gruschwitz, Philipp, additional, Kuhl, Philipp Josef, additional, Petritsch, Bernhard, additional, Kosmala, Aleksander, additional, Bley, Thorsten Alexander, additional, and Gassenmaier, Tobias, additional

Published
2020
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44. Accelerated aortic 4D flow MRI with wave‐CAIPI

Author

Richter, Julian A. J., primary, Wech, Tobias, additional, Weng, Andreas M., additional, Stich, Manuel, additional, Jin, Ning, additional, Kosmala, Aleksander, additional, Bley, Thorsten A., additional, and Köstler, Herbert, additional

Published
2020
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47. B0 shimming of the human heart at 7T

Author

Hock, Michael, primary, Terekhov, Maxim, additional, Stefanescu, Maria Roxana, additional, Lohr, David, additional, Herz, Stefan, additional, Reiter, Theresa, additional, Ankenbrand, Markus, additional, Kosmala, Aleksander, additional, Gassenmaier, Tobias, additional, Juchem, Christoph, additional, and Schreiber, Laura Maria, additional

Published
2020
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50. Tin-filtered 100 kV ultra-low-dose CT of the paranasal sinus: Initial clinical results

Author

Petritsch, Bernhard, Kosmala, Aleksander, Weng, Andreas Max, and Bley, Thorsten Alexander

Subjects
Adult, Male, Soft Tissues, Adolescent, Imaging Techniques, Science, Inflammatory Diseases, Neuroimaging, Signal-To-Noise Ratio, Research and Analysis Methods, Radiation Dosage, Biochemistry, Sensitivity and Specificity, Diagnostic Radiology, Fats, Young Adult, Diagnostic Medicine, Paranasal Sinuses, Medicine and Health Sciences, Paranasal Sinus Diseases, Humans, Mastoid Process, Tomography, Musculoskeletal System, Skeleton, Aged, Retrospective Studies, Aged, 80 and over, Radiology and Imaging, Skull, Biology and Life Sciences, Radiation Exposure, Middle Aged, Lipids, Bone Imaging, Computed Axial Tomography, X-Ray Radiography, Radiographic Image Enhancement, Biological Tissue, Tin, Medicine, Female, Anatomy, Tomography, X-Ray Computed, Algorithms, Research Article, Neuroscience
Abstract

ObjectivesTo investigate the feasibility, diagnostic image quality and radiation dose of 3rd generation dual-source computed tomography (CT) using a tin-filtered 100 kV protocol in patients with suspected acute inflammatory sinus disease.MethodsWe retrospectively evaluated 109 consecutive patients who underwent CT (Siemens SOMATOM Force, Erlangen, Germany) of the paranasal sinus with a new tin-filtered scan-protocol (Sn100 kV; tube current 35 mAs) using iterative reconstruction. Two readers independently assessed subjective image quality using a five-point Likert scale (1 = excellent, 5 = non-diagnostic). Inter-observer agreement was calculated and expressed as percentage of agreement. Noise was determined for calculation of signal-to-noise-ratio (SNR). Effective radiation dose (ED) was calculated from the dose-length-product (DLP).ResultsAll examinations showed diagnostic image quality regarding evaluation of inflammatory sinus disease. On average, subjective general image quality was rated moderate (= 3) with a percentage of agreement between the observers of 81%. The mean image noise was 14.3 HU. The calculated median SNR was 6.0 for intraorbital fat, and 3.6 for the vitreous body, respectively. The median DLP was 2.1 mGy*cm, resulting in a median ED of 0.012 mSv.ConclusionsTaking the study limitations into account, ultra-low-dose tin-filtered CT of the paranasal sinus at a tube voltage of 100 kV utilizing an iterative reconstruction algorithm provides for reliable exclusion of suspected acute inflammatory sinus disease in 100% of the cases.

Published
2019

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