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11 results on '"Koska, Valeria"'

1. Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis

Author

Krämer, Julia, Balloff, Carolin, Weise, Margit, Koska, Valeria, Uthmeier, Yannik, Esderts, Isabell, Nguyen-Minh, Mai, Zimmerhof, Moritz, Hartmann, Alex, Dietrich, Michael, Ingwersen, Jens, Lee, John-Ih, Havla, Joachim, Kümpfel, Tania, Kerschensteiner, Martin, Häußler, Vivien, Heesen, Christoph, Stellmann, Jan-Patrick, Zimmermann, Hanna G., Oertel, Frederike C., Ringelstein, Marius, Brandt, Alexander U., Paul, Friedemann, Aktas, Orhan, Hartung, Hans-Peter, Wiendl, Heinz, Meuth, Sven G., and Albrecht, Philipp

Published
2024
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3. Additional effect of erenumab for patients with chronic migraine treated with onabotulinumtoxin A—real-world data from a preliminary cohort study.

Author

Koelsche, Tristan, Nikolov, Petyo, Koska, Valeria, Ingwersen, Jens, Jansen, Robin, Arat, Ercan, Meuth, Sven G., Albrecht, Philipp, and Lee, John-Ih

Subjects
ERENUMAB, CALCITONIN gene-related peptide, MIGRAINE, COHORT analysis, PEPTIDE receptors
Abstract

Background: This preliminary retrospective cohort study investigates the potential additive prophylactic effect of erenumab, a fully human monoclonal antibody that blocks the calcitonin gene-related peptide receptor, in combination with ongoing onabotulinumtoxin A (onaBoNT-A) treatment in patients suffering from chronic migraine. Methods: The study included 218 patients and investigated the effects of adding erenumab to the existing treatment regimen. The primary outcome was the MIDAS (Migraine Disability Assessment) score assessed 3 months after the introduction of erenumab. Results: The results indicated a significant improvement of the MIDAS score, suggesting a reduction in migraine-related disability following the addition of erenumab to onaBoNT-A. In the inter group comparison, dual therapy showed a significantly greater reduction of the MIDAS when compared to a switch from onaBoNT-A to erenumab monotherapy, but not compared to initiation of onaBoNT-A monotherapy. It is hypothesized that the observed additive effects are due to the independent modes of action of erenumab and onabotulinumtoxin A. Conclusion: This study suggests that the combination of erenumab with onaBoNT-A may offer an improved approach for the treatment of chronic migraine in selected patients. However, the results highlight the need for prospective, controlled studies to validate these findings and determine the optimal combination of treatments tailored to the individual patient. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Protective effects of 4-aminopyridine in experimental optic neuritis and multiple sclerosis

Author

Dietrich, Michael, primary, Koska, Valeria, primary, Hecker, Christina, primary, Göttle, Peter, primary, Hilla, Alexander M, primary, Heskamp, Annemarie, primary, Lepka, Klaudia, primary, Issberner, Andrea, primary, Hallenberger, Angelika, primary, Baksmeier, Christine, primary, Steckel, Julia, primary, Balk, Lisanne, primary, Knier, Benjamin, primary, Korn, Thomas, primary, Havla, Joachim, primary, Martínez-Lapiscina, Elena H, primary, Solà-Valls, Nuria, primary, Manogaran, Praveena, primary, Olbert, Elisabeth D, primary, Schippling, Sven, primary, Cruz-Herranz, Andrés, primary, Yiu, Hao, primary, Button, Julia, primary, Caldito, Natalia Gonzalez, primary, von Gall, Charlotte, primary, Mausberg, Anne K, primary, Stettner, Mark, primary, Zimmermann, Hannah G, primary, Paul, Friedemann, primary, Brandt, Alexander U, primary, Küry, Patrick, primary, Goebels, Norbert, primary, Aktas, Orhan, primary, Berndt, Carsten, primary, Saidha, Shiv, primary, Green, Ari J, primary, Calabresi, Peter A, primary, Fischer, Dietmar, primary, Hartung, Hans-Peter, primary, and Albrecht, Philipp, primary

Published
2020
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8. Supplemental material for Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis; a longitudinal OCT study

Author

Balk, Lisanne J, Coric, Danko, Knier, Benjamin, Zimmermann, Hanna G, Behbehani, Raed, Alroughani, Raed, Martinez-Lapiscina, Elena H, Brandt, Alexander U, Sánchez-Dalmau, Bernardo, Vidal-Jordana, Angela, Albrecht, Philipp, Koska, Valeria, Havla, Joachim, Pisa, Marco, Nolan, Rachel C, Leocani, Letizia, Paul, Friedemann, Aktas, Orhan, Montalban, Xavier, Balcer, Laura J, Villoslada, Pablo, Outteryck, Olivier, Korn, Thomas, and Petzold, Axel

Subjects
FOS: Clinical medicine, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental Material for Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis; a longitudinal OCT study by Lisanne J Balk, Danko Coric Benjamin Knier Hanna G Zimmermann Raed Behbehani Raed Alroughani Elena H Martinez-Lapiscina Alexander U Brandt Bernardo Sánchez-Dalmau Angela Vidal-Jordana Philipp Albrecht, Valeria Koska, Joachim Havla Marco Pisa Rachel C Nolan Letizia LeocaniFriedemann Paul, Orhan Xavier Montalban Aktas , Laura J Balcer Pablo Villoslada Olivier OutteryckThomas Korn, Axel Petzold and on behalf of the IMSVISUAL consortium in Multiple Sclerosis Journal – Experimental, Translational and Clinical

Published
2019
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10. Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis; a longitudinal OCT study.

Author

Balk, Lisanne J., Coric, Danko, Knier, Benjamin, Zimmermann, Hanna G., Behbehani, Raed, Alroughani, Raed, Martinez-Lapiscina, Elena H., Brandt, Alexander U., Sánchez-Dalmau, Bernardo, Vidal-Jordana, Angela, Albrecht, Philipp, Koska, Valeria, Havla, Joachim, Pisa, Marco, Nolan, Rachel C., Leocani, Letizia, Paul, Friedemann, Aktas, Orhan, Montalban, Xavier, and Balcer, Laura J.

Abstract

Background: The association of peripapillary retinal nerve fibre layer (pRNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness with neurodegeneration in multiple sclerosis (MS) is well established. The relationship of the adjoining inner nuclear layer (INL) with inflammatory disease activity is less well understood. Objective: The objective of this paper is to investigate the relationship of INL volume changes with inflammatory disease activity in MS.Methods In this longitudinal, multi-centre study, optical coherence tomography (OCT) and clinical data (disability status, relapses and MS optic neuritis (MSON)) were collected in 785 patients with MS (68.3% female) and 92 healthy controls (63.4% female) from 11 MS centres between 2010 and 2017 and pooled retrospectively. Data on pRNFL, GCIPL and INL were obtained at each centre. Results: There was a significant increase in INL volume in eyes with new MSON during the study (N = 61/1562, β = 0.01 mm3, p < .001). Clinical relapses (other than MSON) were significantly associated with increased INL volume (β = 0.005, p = .025). INL volume was independent of disease progression (β = 0.002 mm3, p = .474). Conclusion: Our data demonstrate that an increase in INL volume is associated with MSON and the occurrence of clinical relapses. Therefore, INL volume changes may be useful as an outcome marker for inflammatory disease activity in MSON and MS treatment trials. [ABSTRACT FROM AUTHOR]

Published
2019
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11. Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis; a longitudinal OCT study

Author

Elena H. Martinez-Lapiscina, Joachim Havla, Olivier Outteryck, Axel Petzold, Friedemann Paul, Raed Behbehani, Marco Pisa, Letizia Leocani, Angela Vidal-Jordana, Philipp Albrecht, Thomas Korn, Alexander U. Brandt, Rachel Nolan, Danko Coric, Valeria Koska, Xavier Montalban, Bernardo Sanchez-Dalmau, Hanna Zimmermann, Lisanne J. Balk, Raed Alroughani, Benjamin Knier, Orhan Aktas, Pablo Villoslada, Laura J. Balcer, [Balk LJ, Coric D] Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands. [Knier B] Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Germany. [Zimmermann HG] Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany. Berlin Institute of Health, NeuroCure Clinical Research Center, Berlin, Germany. [Behbehani R] Al-Bahar Ophthalmology Centre, Ibn Sina Hospital, Kuwait. [Alroughani R] Division of Neurology, Department of Medicine, Amiri Hospital, Kuwait. [Vidal-Jordana A] Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Servei de Neuroimmunologia Clínica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Montalban X] Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Servei de Neuroimmunologia Clínica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Division of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, Canada, Hospital Universitari Vall d'Hebron, Neurology, Amsterdam Neuroscience - Neuroinfection & -inflammation, Ophthalmology, APH - Mental Health, APH - Methodology, Balk, Lisanne J, Coric, Danko, Knier, Benjamin, Zimmermann, Hanna G, Behbehani, Raed, Alroughani, Raed, Martinez-Lapiscina, Elena H, Brandt, Alexander U, Sánchez-Dalmau, Bernardo, Vidal-Jordana, Angela, Albrecht, Philipp, Koska, Valeria, Havla, Joachim, Pisa, Marco, Nolan, Rachel C, Leocani, Letizia, Paul, Friedemann, Aktas, Orhan, Montalban, Xavier, Balcer, Laura J, Villoslada, Pablo, Outteryck, Olivier, Korn, Thoma, Petzold, Axel, and Vall d'Hebron Barcelona Hospital Campus

Subjects
medicine.medical_specialty, Ulls - Tomografia, inner nuclear layer, Órganos de los Sentidos::Ojo::Retina [ANATOMÍA], Nerve fibre layer, Esclerosi múltiple, Investigative Techniques::Optical Imaging::Tomography, Optical::Tomography, Optical Coherence [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], multiple sclerosis, Retina, Disease activity, Multiple sclerosis, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Ophthalmology, Medicine, Inner nuclear layer, Inflammation, optical coherence tomography, técnicas de investigación::imágenes ópticas::tomografía óptica::tomografía de coherencia óptica [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Optical coherence tomography, Técnicas de Investigación::Imagen Óptica::Tomografía Óptica::Tomografía de Coherencia Óptica [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], business.industry, Neurodegeneration, enfermedades del sistema nervioso::enfermedades del sistema nervioso::enfermedades desmielinizantes::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple [ENFERMEDADES], Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis [DISEASES], Retinal, medicine.disease, Ganglion, Original Research Paper, medicine.anatomical_structure, chemistry, multiple sclerosi, Neurology (clinical), sense organs, Sense Organs::Eye::Retina [ANATOMY], Function and Dysfunction of the Nervous System, business
Abstract

Inner nuclear layer; Multiple sclerosis; Optical coherence tomography Capa nuclear interna; Esclerosis múltiple; Tomografía de coherencia óptica Capa nuclear interior; Esclerosi múltiple; Tomografia de coherència òptica Background: The association of peripapillary retinal nerve fibre layer (pRNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness with neurodegeneration in multiple sclerosis (MS) is well established. The relationship of the adjoining inner nuclear layer (INL) with inflammatory disease activity is less well understood. Objective: The objective of this paper is to investigate the relationship of INL volume changes with inflammatory disease activity in MS. Methods In this longitudinal, multi-centre study, optical coherence tomography (OCT) and clinical data (disability status, relapses and MS optic neuritis (MSON)) were collected in 785 patients with MS (68.3% female) and 92 healthy controls (63.4% female) from 11 MS centres between 2010 and 2017 and pooled retrospectively. Data on pRNFL, GCIPL and INL were obtained at each centre. Results: There was a significant increase in INL volume in eyes with new MSON during the study (N=61/1562, β=0.01mm3, p

Published
2019
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