274 results on '"Koshy, Anita A."'
Search Results
2. Toxoplasma type II effector GRA15 has limited influence in vivo.
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Merritt, Emily, Kochanowsky, Joshua, Hervé, Perrine, Watson, Alison, and Koshy, Anita
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Humans ,Animals ,Mice ,Toxoplasma ,Protozoan Proteins ,Signal Transduction ,Cytokines ,NF-kappa B - Abstract
Toxoplasma gondii is an intracellular parasite that establishes a long-term infection in the brain of many warm-blooded hosts, including humans and rodents. Like all obligate intracellular microbes, Toxoplasma uses many effector proteins to manipulate the host cell to ensure parasite survival. While some of these effector proteins are universal to all Toxoplasma strains, some are polymorphic between Toxoplasma strains. One such polymorphic effector is GRA15. The gra15 allele carried by type II strains activates host NF-κB signaling, leading to the release of cytokines such as IL-12, TNF, and IL-1β from immune cells infected with type II parasites. Prior work also suggested that GRA15 promotes early host control of parasites in vivo, but the effect of GRA15 on parasite persistence in the brain and the peripheral immune response has not been well defined. For this reason, we sought to address this gap by generating a new IIΔgra15 strain and comparing outcomes at 3 weeks post infection between WT and IIΔgra15 infected mice. We found that the brain parasite burden and the number of macrophages/microglia and T cells in the brain did not differ between WT and IIΔgra15 infected mice. In addition, while IIΔgra15 infected mice had a lower number and frequency of splenic M1-like macrophages and frequency of PD-1+ CTLA-4+ CD4+ T cells and NK cells compared to WT infected mice, the IFN-γ+ CD4 and CD8 T cell populations were equivalent. In summary, our results suggest that in vivo GRA15 may have a subtle effect on the peripheral immune response, but this effect is not strong enough to alter brain parasite burden or parenchymal immune cell number at 3 weeks post infection.
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- 2024
3. ROP16-mediated activation of STAT6 enhances cyst development of type III Toxoplasma gondii in neurons.
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Kochanowsky, Joshua, Chandrasekaran, Sambamurthy, Sanchez, Jacqueline, Thomas, Kaitlin, and Koshy, Anita
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Mice ,Animals ,Humans ,Toxoplasma ,Protozoan Proteins ,Phosphorylation ,Central Nervous System ,Gene Expression Regulation ,STAT6 Transcription Factor - Abstract
Toxoplasma gondii establishes a long-lived latent infection in the central nervous system (CNS) of its hosts. Reactivation in immunocompromised individuals can lead to life threatening disease. Latent infection is driven by the ability of the parasite to convert from the acute-stage tachyzoite to the latent-stage bradyzoite which resides in long-lived intracellular cysts. While much work has focused on the parasitic factors that drive cyst development, the host factors that influence encystment are not well defined. Here we show that a polymorphic secreted parasite kinase (ROP16), that phosphorylates host cell proteins, mediates efficient encystment of T. gondii in a stress-induced model of encystment and primary neuronal cell cultures (PNCs) in a strain-specific manner. Using short-hairpin RNA (shRNA) knockdowns in human foreskin fibroblasts (HFFs) and PNCs from transgenic mice, we determined that ROP16s cyst enhancing abilities are mediated, in part, by phosphorylation-and therefore activation-of the host cell transcription factor STAT6. To test the role of STAT6 in vivo, we infected wild-type (WT) and STAT6KO mice, finding that, compared to WT mice, STAT6KO mice have a decrease in CNS cyst burden but not overall parasite burden or dissemination to the CNS. Finally, we found a similar ROP16-dependent encystment defect in human pluripotent stem cell-derived neurons. Together, these findings identify a host cell factor (STAT6) that T. gondii manipulates in a strain-specific manner to generate a favorable encystment environment.
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- 2023
4. Author Correction: A positive feedback loop controls Toxoplasma chronic differentiation
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Licon, M. Haley, Giuliano, Christopher J., Chan, Alex W., Chakladar, Sundeep, Eberhard, Julia N., Shallberg, Lindsey A., Chandrasekaran, Sambamurthy, Waldman, Benjamin S., Koshy, Anita A., Hunter, Christopher A., and Lourido, Sebastian
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- 2024
- Full Text
- View/download PDF
5. A positive feedback loop controls Toxoplasma chronic differentiation
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Licon, M. Haley, Giuliano, Christopher J., Chan, Alex W., Chakladar, Sundeep, Eberhard, Julia N., Shallberg, Lindsey A., Chandrasekaran, Sambamurthy, Waldman, Benjamin S., Koshy, Anita A., Hunter, Christopher A., and Lourido, Sebastian
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- 2023
- Full Text
- View/download PDF
6. Phase 2 clinical trial evaluating abatacept in patients with steroid-refractory chronic graft-versus-host disease
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Koshy, Anita G., Kim, Haesook T., Liegel, Jessica, Arnason, Jon, Ho, Vincent T., Antin, Joseph H., Joyce, Robin, Cutler, Corey, Gooptu, Mahasweta, Nikiforow, Sarah, Logan, Emma K., Elavalakanar, Pavania, Narcis, Michele, Stroopinsky, Dina, Avigan, Zachary M., Boussi, Leora, Stephenson, Susan, El Banna, Hassan, Bindal, Poorva, Cheloni, Giulia, Avigan, David E., Soiffer, Robert J., and Rosenblatt, Jacalyn
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- 2023
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7. IFN-γ stimulated murine and human neurons mount anti-parasitic defenses against the intracellular parasite Toxoplasma gondii
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Chandrasekaran, Sambamurthy, Kochanowsky, Joshua A., Merritt, Emily F., Lagas, Joseph S., Swannigan, Ayesha, and Koshy, Anita A.
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- 2022
- Full Text
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8. The latent stage ofToxoplasma gondiiis targeted by the immune response and host protective
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Shallberg, Lindsey A., primary, Eberhard, Julia N., additional, Winn, Aaron, additional, Chandrasekaran, Sambamurthy, additional, Giuliano, Christopher J., additional, Merritt, Emily F., additional, Willis, Elinor, additional, Christian, David A., additional, Aldridge, Daniel L., additional, Bunkofske, Molly, additional, Jacquet, Maxime, additional, Dzierszinski, Florence, additional, Katifori, Eleni, additional, Lourido, Sebastian, additional, Koshy, Anita A., additional, and Hunter, Christopher A., additional
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- 2024
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9. A new era of immuno-oncology in acute myeloid leukemia - antibody-based therapies and immune checkpoint inhibition
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Koshy, Anita G., Daver, Naval G., and Fathi, Amir T.
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- 2020
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10. Incidence of thrombosis and hemorrhage in hospitalized cancer patients with COVID‐19
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Patell, Rushad, Bogue, Thomas, Bindal, Poorva, Koshy, Anita, Merrill, Mwanasha, Aird, William C., Bauer, Kenneth A., and Zwicker, Jeffrey I.
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- 2020
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11. Chronic Toxoplasma gondii infection curtails the cytotoxic potential of acute T cell responses to West Nile virus in the brain.
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Uhrlaub, Jennifer L, primary, McGovern, Kathryn E., additional, Merritt, Emily F., additional, Kuhns, Michael S., additional, Koshy, Anita A., additional, and Nikolich, Janko Z., additional
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- 2024
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12. Contributors
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Abrams, Gary M., primary, Albers, Gregory W., additional, Amans, Matthew R., additional, Aminoff, Michael J., additional, Batla, Amit, additional, Betjemann, John P., additional, Camilleri, Michael, additional, Chen, Robert, additional, Christine, Chadwick W., additional, Coleman, Kyle J., additional, Davies-Jones, G.A.B., additional, DeAngelis, Lisa M., additional, Dhand, Amar, additional, Dillon, William P., additional, Douglas, Vanja C., additional, Fox, Christine, additional, Furman, Joseph M., additional, Gelb, Douglas J., additional, Gladstone, David J., additional, Glynn, Simon M., additional, Goodin, Douglas S., additional, Goodman, Brent P., additional, Greenlee, John E., additional, Guterman, Elan, additional, Halabi, Cathra, additional, Hallett, Mark, additional, Halperin, John J., additional, Harris, Shelby, additional, Hemphill, J. Claude, additional, Hurko, Orest, additional, Irani, Sarosh R., additional, Jo, Jasmin, additional, Josephson, S. Andrew, additional, Kaley, Thomas J., additional, Kim, Anthony S., additional, Ko, Nerissa U., additional, Koshy, Anita A., additional, Kraler, Lironn, additional, Krumholz, Allan, additional, Leonard, John M., additional, Levin, Morris, additional, Manno, Edward M., additional, Mastaglia, Frank L., additional, Maurer, Carine W., additional, McCall, Andrew A., additional, Messing, Robert O., additional, Miravalle, Augusto, additional, Monderer, Renee, additional, Morren, John A., additional, Muccilli, Alexandra D., additional, Muir, Ryan T., additional, Murphy, Olwen C., additional, Nash, Kendall, additional, Ooi, Winnie W., additional, Pal, Pramod K., additional, Panicker, Jalesh N., additional, Parent, Jack M., additional, Peluso, Michael J., additional, Perfect, John R., additional, Peyvandi, Shabnam, additional, Pfeiffer, Ronald F., additional, Phillips, Steven M., additional, Poncelet, Ann Noelle, additional, Prasad, Sashank, additional, Prasad, Shweta, additional, Probasco, John C., additional, Purdy, Kaylynn, additional, Rabinstein, Alejandro A., additional, Ralph, Jeffrey W., additional, Ramachandran, Prashanth S., additional, Roos, Karen L., additional, Rose-Innes, Andrew P., additional, Safarpour, Delaram, additional, Schiff, David, additional, Schipper, Hyman M., additional, Shah, Maulik P., additional, Sharzehi, Kaveh, additional, Shaw, Pamela J., additional, Spudich, Serena, additional, Srinivasan, Jayashri, additional, Stern, Barney J., additional, Sun, Chung-Huan Johnny, additional, Sussman, Jon D., additional, Thorpy, Michael, additional, Verber, Nick S., additional, VoduŠek, David B., additional, Weissenborn, Karin, additional, Williams, Linda S., additional, Wilson, Michael R., additional, and Zochodne, Douglas W., additional
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- 2021
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13. Parasitic Infections of the Central Nervous System
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Koshy, Anita A., primary
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- 2021
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14. Parasite potpourri: Toxoplasma gondii lineage tracing in vivo
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Koshy, Anita A.
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- 2022
- Full Text
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15. Internalization and TLR‐dependent type I interferon production by monocytes in response to Toxoplasma gondii
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Han, Seong‐Ji, Melichar, Heather J, Coombes, Janine L, Chan, Shiao Wei, Koshy, Anita A, Boothroyd, John C, Barton, Gregory M, and Robey, Ellen A
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Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Immunology ,Prevention ,Vaccine Related ,Emerging Infectious Diseases ,Foodborne Illness ,Infectious Diseases ,Biodefense ,Aetiology ,2.1 Biological and endogenous factors ,2.2 Factors relating to the physical environment ,Inflammatory and immune system ,Infection ,Animals ,Immunity ,Innate ,Interferon-beta ,Mice ,Mice ,Knockout ,Monocytes ,Myeloid Differentiation Factor 88 ,Neutrophils ,Signal Transduction ,Toll-Like Receptors ,Toxoplasma ,Toxoplasmosis ,Animal ,Biochemistry and cell biology - Abstract
The classic anti-viral cytokine interferon (IFN)-β can be induced during parasitic infection, but relatively little is know about the cell types and signaling pathways involved. Here we show that inflammatory monocytes (IMs), but not neutrophils, produce IFN-β in response to T. gondii infection. This difference correlated with the mode of parasite entry into host cells, with phagocytic uptake predominating in IMs and active invasion predominating in neutrophils. We also show that expression of IFN-β requires phagocytic uptake of the parasite by IMs, and signaling through Toll-like receptors (TLRs) and MyD88. Finally, we show that IMs are major producers of IFN-β in mesenteric lymph nodes following in vivo oral infection of mice, and mice lacking the receptor for type I IFN-1 show higher parasite loads and reduced survival. Our data reveal a TLR and internalization-dependent pathway in IMs for IFN-β induction to a non-viral pathogen.
- Published
- 2014
16. Influenza-associated global amnesia and hippocampal imaging abnormality
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Lopez, Jonathan, Lomen-Hoerth, Catherine, Deutsch, Gayle K, Kerchner, Geoffrey A, and Koshy, Anita
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Medical Microbiology ,Biomedical and Clinical Sciences ,Clinical Sciences ,Biodefense ,Vaccine Related ,Prevention ,Infectious Diseases ,Biomedical Imaging ,Pneumonia & Influenza ,Acquired Cognitive Impairment ,Behavioral and Social Science ,Emerging Infectious Diseases ,Influenza ,Brain Disorders ,Neurosciences ,2.1 Biological and endogenous factors ,Aetiology ,Infection ,Amnesia ,Diffusion Magnetic Resonance Imaging ,Hippocampus ,Humans ,Influenza A virus ,Influenza ,Human ,Male ,Neuropsychological Tests ,Recovery of Function ,Young Adult ,Influenza-associated encephalopathy ,Diffusion-weighted imaging ,Psychology ,Cognitive Sciences ,Experimental Psychology ,Biological psychology ,Clinical and health psychology - Abstract
The acute phase of influenza infection is rarely associated with significant cognitive dysfunction. We describe a case of a 24 year-old man who developed global amnesia in the acute phase of influenza A infection. His deficits resolved over the course of several weeks. Transient abnormalities of diffusion and T2-weighted imaging were seen in the bilateral hippocampi. We review cerebral complications of influenza and discuss the possible role of previously proposed mechanisms in our patient's case.
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- 2014
17. High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription
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Butterworth, Simon, primary, Kordova, Kristina, additional, Chandrasekaran, Sambamurthy, additional, Thomas, Kaitlin K., additional, Torelli, Francesca, additional, Lockyer, Eloise J., additional, Edwards, Amelia, additional, Goldstone, Robert, additional, Koshy, Anita A., additional, and Treeck, Moritz, additional
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- 2023
- Full Text
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18. Cerebral toxoplasmosis
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Koshy, Anita A., primary, Harris, Tajie H., additional, and Lodoen, Melissa B., additional
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- 2020
- Full Text
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19. List of contributors
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Behnke, Michael S., primary, Besteiro, Sébastien, additional, Billker, Oliver, additional, Blanchard, Nicolas, additional, Boothroyd, John C., additional, Botté, Cyrille, additional, Boyer, Kenneth M., additional, Boyle, Jon P., additional, Brown, Kevin M., additional, Bzik, David J., additional, Carruthers, Vern B., additional, Cesbron-Delauw, Marie-France, additional, Cohen, William, additional, Coppens, Isabelle, additional, Dardé, Marie-Laure, additional, de-la-Torre, Alejandra, additional, Dovgin, Samantha, additional, Dubey, J.P., additional, Dubremetz, Jean-François, additional, Feagin, Jean E., additional, Ferguson, David J.P., additional, Finkelstein, Lauren, additional, Fox, Barbara A., additional, Gomez-Marin, Jorge Enrique, additional, Grigg, Michael E., additional, Groß, Uwe, additional, Gubbels, Marc-Jan, additional, Hakimi, Mohamed-Ali, additional, Harb, Omar S., additional, Harris, Tajie H., additional, Hunter, Christopher A., additional, Jacot, Damien, additional, Jeffers, Victoria, additional, Khan, Asis, additional, Kim, Kami, additional, Kissinger, Jessica C., additional, Klinger, Christen M., additional, Kloehn, Joachim, additional, Knoll, Laura J., additional, Koshy, Anita A., additional, Krishnan, Aarti, additional, Lebrun, Maryse, additional, Lindsay, David S., additional, Lodoen, Melissa B., additional, Lourido, Sebastian, additional, Lüder, Carsten G.K., additional, McConville, Malcolm J., additional, McLeod, Rima, additional, Meissner, Markus, additional, Mercier, Aurélien, additional, Mordue, Dana G., additional, Moreno, Silvia N.J., additional, Morrissette, Naomi, additional, Pace, Douglas A., additional, Parsons, Marilyn, additional, Reichard, Utz, additional, Roberts, Craig W., additional, Robey, Ellen A., additional, Roos, David S., additional, Saeij, Jeroen P.J., additional, Salvioni, Anna, additional, Seeber, Frank, additional, Sheiner, Lilach, additional, Sibley, L. David, additional, Sinai, Anthony P., additional, Soldati-Favre, Dominique, additional, Striepen, Boris, additional, Su, Chunlei, additional, Sullivan, William J., additional, Tonkin, Christopher J., additional, van Dooren, Giel G., additional, Wastling, Jonathan, additional, Weiss, Louis M., additional, and Woods, Stuart, additional
- Published
- 2020
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20. Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential mechanism for parasite spread
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Coombes, Janine L, Charsar, Brittany A, Han, Seong-Ji, Halkias, Joanna, Chan, Shiao Wei, Koshy, Anita A, Striepen, Boris, and Robey, Ellen A
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Veterinary Sciences ,Agricultural ,Veterinary and Food Sciences ,Foodborne Illness ,Biodefense ,Infectious Diseases ,Emerging Infectious Diseases ,2.1 Biological and endogenous factors ,Infection ,Inflammatory and immune system ,Animals ,Cell Movement ,Disease Models ,Animal ,Immunity ,Innate ,Intestinal Mucosa ,Intestine ,Small ,Mice ,Mice ,Transgenic ,Microscopy ,Confocal ,Neutrophil Infiltration ,Neutrophils ,Toxoplasma ,Toxoplasmosis ,neutrophil motility ,dynamic imaging ,gut ,mucosal immunology - Abstract
Toxoplasma gondii infection occurs through the oral route, but we lack important information about how the parasite interacts with the host immune system in the intestine. We used two-photon laser-scanning microscopy in conjunction with a mouse model of oral T. gondii infection to address this issue. T. gondii established discrete foci of infection in the small intestine, eliciting the recruitment and transepithelial migration of neutrophils and inflammatory monocytes. Neutrophils accounted for a high proportion of actively invaded cells, and we provide evidence for a role for transmigrating neutrophils and other immune cells in the spread of T. gondii infection through the lumen of the intestine. Our data identify neutrophils as motile reservoirs of T. gondii infection and suggest a surprising retrograde pathway for parasite spread in the intestine.
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- 2013
21. Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions
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Koshy, Anita A, Fouts, Ashley E, Lodoen, Melissa B, Alkan, Ozan, Blau, Helen M, and Boothroyd, John C
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Biological Sciences ,Vaccine Related ,Foodborne Illness ,Biodefense ,Emerging Infectious Diseases ,Prevention ,Infectious Diseases ,2.2 Factors relating to the physical environment ,Aetiology ,2.1 Biological and endogenous factors ,Infection ,Animals ,Host-Parasite Interactions ,Integrases ,Mice ,Mice ,Transgenic ,Microscopy ,Fluorescence ,Plasmids ,Recombination ,Genetic ,Toxoplasma ,Toxoplasmosis ,Transduction ,Genetic ,Technology ,Medical and Health Sciences ,Developmental Biology ,Biological sciences - Abstract
We describe a Toxoplasma gondii strain that will permit the use of site-specific recombination to study the host-parasite interactions of this organism. This Toxoplasma strain efficiently injects a Cre fusion protein into host cells. In a Cre-reporter cell line, a single parasite invasion induced Cre-mediated recombination in 95% of infected host cells. By infecting Cre-reporter mice with these parasites, we also monitored host-cell infection in vivo.
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- 2010
22. Author Correction: A positive feedback loop controls Toxoplasma chronic differentiation
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Licon, M. Haley, primary, Giuliano, Christopher J., additional, Chan, Alex W., additional, Chakladar, Sundeep, additional, Eberhard, Julia N., additional, Shallberg, Lindsey A., additional, Chandrasekaran, Sambamurthy, additional, Waldman, Benjamin S., additional, Koshy, Anita A., additional, Hunter, Christopher A., additional, and Lourido, Sebastian, additional
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- 2023
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23. Aging with Toxoplasma gondii results in pathogen clearance, resolution of inflammation, and minimal consequences to learning and memory
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McGovern, Kathryn E., Cabral, Carla M., Morrison, Helena W., and Koshy, Anita A.
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- 2020
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24. 320 - Toxoplasmosis
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Koshy, Anita A.
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- 2024
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25. Three-Dimensional Reconstruction of Toxoplasma–Neuron Interactions In Situ
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Cabral, Carla M., primary, Merritt, Emily F., additional, and Koshy, Anita A., additional
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- 2019
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26. Microarray Detection of Human Parainfluenzavirus 4 Infection Associated with Respiratory Failure in an Immunocompetent Adult
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Chiu, Charles Y, Rouskin, Silvi, Koshy, Anita, Urisman, Anatoly, Fischer, Kael, Yagi, Shigeo, Schnurr, David, Eckburg, Paul B, Tompkins, Lucy S, Blackburn, Brian G, Merker, Jason D, Patterson, Bruce K, Ganem, Don, and DeRisi, Joseph L
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Infectious Diseases ,Biotechnology ,Lung ,Aetiology ,2.2 Factors relating to the physical environment ,Infection ,Adult ,Bronchiolitis ,Viral ,Female ,Humans ,Oligonucleotide Array Sequence Analysis ,Parainfluenza Virus 4 ,Human ,Pneumonia ,Viral ,Rubulavirus Infections ,Serologic Tests ,Tomography Scanners ,X-Ray Computed ,Biological Sciences ,Medical and Health Sciences ,Microbiology - Abstract
A pan-viral DNA microarray, the Virochip (University of California, San Francisco), was used to detect human parainfluenzavirus 4 (HPIV-4) infection in an immunocompetent adult presenting with a life-threatening acute respiratory illness. The virus was identified in an endotracheal aspirate specimen, and the microarray results were confirmed by specific polymerase chain reaction and serological analysis for HPIV-4. Conventional clinical laboratory testing using an extensive panel of microbiological tests failed to yield a diagnosis. This case suggests that the potential severity of disease caused by HPIV-4 in adults may be greater than previously appreciated and illustrates the clinical utility of a microarray for broad-based viral pathogen screening.
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- 2006
27. Mapping host-microbe transcriptional interactions by dual perturb-seq
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Butterworth, Simon, primary, Kordova, Kristina, additional, Chandrasekaran, Sambamurthy, additional, Thomas, Kaitlin K, additional, Torelli, Francesca, additional, Lockyer, Eloise Jennifer, additional, Edwards, Amelia, additional, Goldstone, Robert, additional, Koshy, Anita A, additional, and Treeck, Moritz, additional
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- 2023
- Full Text
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28. Phase II clinical trial evaluating Abatacept in patients with steroid-refractory chronic graft versus host disease
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Koshy, Anita G., primary, Kim, Haesook T., additional, Liegel, Jessica, additional, Arnason, Jon E., additional, Ho, Vincent T., additional, Antin, Joseph H., additional, Joyce, Robin, additional, Cutler, Corey S., additional, Gooptu, Mahasweta, additional, Nikiforow, Sarah, additional, Logan, Emma K., additional, Elavalakanar, Pavania, additional, Narcis, Michele, additional, Stroopinsky, Dina, additional, Avigan, Zachary M., additional, Boussi, Leora, additional, Stephenson, Susan L, additional, El Banna, Hassan, additional, Bindal, Poorva, additional, Cheloni, Giulia, additional, Avigan, David E., additional, Soiffer, Robert J., additional, and Rosenblatt, Jacalyn, additional
- Published
- 2023
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29. Metabolic Effects of JAK1/2 Inhibition in Patients with Myeloproliferative Neoplasms
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Sapre, Manali, Tremblay, Douglas, Wilck, Eric, James, Annie, Leiter, Amanda, Coltoff, Alexander, Koshy, Anita G., Kremyanskaya, Marina, Hoffman, Ronald, Mascarenhas, John O., and Gallagher, Emily J.
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- 2019
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30. Understanding neuroinflammation through central nervous system infections
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Johnson, Hannah J., primary and Koshy, Anita A., additional
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- 2022
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31. ROP16-mediated activation of STAT6 facilitates encystment of type IIIToxoplasma gondiiin neurons
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Kochanowsky, Joshua A., primary, Chandrasekaran, Sambamurthy, additional, Sanchez, Jacqueline R., additional, Thomas, Kaitlin K., additional, and Koshy, Anita A., additional
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- 2022
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32. Impact of secondary TCR engagement on the heterogeneity of pathogen-specific CD8+ T cell response during acute and chronic toxoplasmosis
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Shallberg, Lindsey A., primary, Phan, Anthony T., additional, Christian, David A., additional, Perry, Joseph A., additional, Haskins, Breanne E., additional, Beiting, Daniel P., additional, Harris, Tajie H., additional, Koshy, Anita A., additional, and Hunter, Christopher A., additional
- Published
- 2022
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33. Utilizing Toxoplasma gondii To Understand Neuron-Specific Neuroinflammation
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Rodgers, Kathleen, Lybarger, Lonnie, Koshy, Anita A., Johnson, Hannah, Rodgers, Kathleen, Lybarger, Lonnie, Koshy, Anita A., and Johnson, Hannah
- Abstract
Toxoplasma gondii infects up to one third of the world’s population. The parasite can persist for the life of the host by hiding in neurons in the Central Nervous System (CNS). It was thought that neurons permitted this chronic infection due to a lack of innate immune capabilities including decreased expression of cytokine and immune cell receptors, as well as an inability to intracellularly clear the parasite. Evidence in the last five years has shown that neurons are capable of intracellular clearance, often in unusual ways, and are likely able to interact with cytotoxic immune cells. This brings into question the role of neurons during T. gondii infection as neurons are the primary CNS cell with which T. gondii interacts and persists in in vivo. The goal of this dissertation is to define T. gondii-neuron interaction in vivo. I first demonstrate that T. gondii’s neurotropism can be leveraged to deliver proteins to neurons. Then, I perform RNA-seq analysis to compare the expression of T. gondii-injected neurons (TINs) to neurons to neurons in an uninfected brain. These analyses revealed that TINs “transcriptomes” included immune cell transcripts, indicating the clustering of immune cells around TINs. By comparing this in vivo dataset with RNA-seq data from primary cortical neurons infected with either T. gondii or West Nile Virus, I determined that neurons that interact with T. gondii upregulate cytokine pathways, many of which are singular to T. gondii and not shared by virally infected neurons. Finally, to generate a better understanding of how T. gondii alters neurons in vivo, I have been pioneering single cell isolation and sequencing of TINs. This work has demonstrated that, in the infected brain, infiltrating immune cells must be removed in order isolate enough neurons for sequencing. In addition, neurons from infected brain are extremely fragile, suggesting that methods that do not require cell sorting and/or in which cells can first be fixed, will likely be
- Published
- 2022
34. A Novel Combination of TGF-β Inhibitor and DC/AML Fusion Vaccine for Management of AML in an Immunocompetent Murine Model
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Bindal, Poorva, primary, Liegel, Jessica, additional, Stroopinsky, Dina, additional, Koshy, Anita G., additional, Cheloni, Giulia, additional, Leukam, Michael, additional, Torres, Daniela, additional, Hauser, Joshua, additional, Dufort, Kenel, additional, Yoo, Seo Yeon, additional, Kufe, Donald, additional, Wucherpfennig, Kai, additional, Rosenblatt, Jacalyn, additional, and Avigan, David, additional
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- 2022
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35. Post-Transplant Vaccination with a Personalized Dendritic Cell/AML Fusion Cell Vaccine for Prevention of Relapse
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Liegel, Jessica, primary, Bindal, Poorva, additional, Stone, Richard M, additional, Soiffer, Robert J., additional, Stroopinsky, Dina, additional, Cheloni, Giulia, additional, Bisharat, Lina, additional, Torres, Daniela, additional, Rahimian, Maryam, additional, Yoo, Seo Yeon, additional, Logan, Emma, additional, Elavalakanar, Pavania, additional, El Banna, Hassan, additional, Hauser, Joshua, additional, Koshy, Anita G., additional, Ho, Vincent T., additional, Romee, Rizwan, additional, Neuberg, Donna, additional, Liu, Yiwen, additional, Mendez, Lourdes, additional, Dias, Ajoy, additional, Ebert, Benjamin, additional, Kufe, Donald, additional, Avigan, David, additional, and Rosenblatt, Jacalyn, additional
- Published
- 2022
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36. Synergism between CAR T Cells and a Personalized Tumor Vaccine in Hematological Malignances
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Cheloni, Giulia, primary, Capelletti, Marzia, additional, Torres, Daniela, additional, Bindal, Poorva, additional, Liegel, Jessica, additional, Stroopinsky, Dina, additional, Bisharat, Lina, additional, Rahimian, Maryam, additional, Yoo, Seo Yeon, additional, Hauser, Joshua, additional, Koshy, Anita G., additional, Dufort, Kenel, additional, Clohessy, John, additional, Kufe, Donald, additional, Themeli, Maria, additional, Sadelain, Michel, additional, Rosenblatt, Jacalyn, additional, and Avigan, David E., additional
- Published
- 2022
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37. Treatment with DC/AML Fusion Vaccine and CD3xCD123 Bi-Specific T-Cell Engager (CD123-CODV-TCE) for Treatment of Acute Myeloid Leukemia
- Author
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Stroopinsky, Dina, primary, Koshy, Anita G., additional, Liegel, Jessica, additional, Nahas, Myrna R., additional, Cheloni, Giulia, additional, Hauser, Joshua, additional, Torres, Daniela, additional, Bindal, Poorva, additional, Rahimian, Maryam, additional, Bisharat, Lina, additional, Yoo, Seo Yeon, additional, Fraenkel, Paula, additional, Yildirim, Ozlem, additional, Bonnevaux, Helene, additional, Guerif, Stephane, additional, Kufe, Donald, additional, Rosenblatt, Jacalyn, additional, and Avigan, David, additional
- Published
- 2022
- Full Text
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38. Phase II Clinical Trial of Abatacept for Steroid-Refractory Chronic Graft Versus Host Disease
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Koshy, Anita G., primary, Kim, Haesook, additional, Stroopinsky, Dina, additional, Liegel, Jessica, additional, Arnason, Jon E., additional, Ho, Vincent T., additional, Antin, Joseph H., additional, Joyce, Robin M., additional, Cutler, Corey, additional, Gooptu, Mahasweta, additional, Nikiforow, Sarah, additional, Logan, Emma, additional, Elavalakanar, Pavania, additional, Stephenson, Susan, additional, El Banna, Hassan, additional, Bindal, Poorva, additional, Cheloni, Giulia, additional, Avigan, David E., additional, Soiffer, Robert J., additional, and Rosenblatt, Jacalyn, additional
- Published
- 2022
- Full Text
- View/download PDF
39. 79 - Bacterial, Fungal, and Parasitic Diseases of the Nervous System
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Anderson, Nicolaas C., Koshy, Anita A., and Roos, Karen L.
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- 2022
- Full Text
- View/download PDF
40. Impact of secondary TCR engagement on the heterogeneity of pathogen-specific CD8+T cell response during acute and chronic toxoplasmosis
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Shallberg, Lindsey A, primary, Phan, Anthony T, additional, Christian, David A, additional, Perry, Joseph A, additional, Haskins, Breanne E, additional, Beiting, Daniel P, additional, Harris, Tajie H, additional, Koshy, Anita A, additional, and Hunter, Christopher A, additional
- Published
- 2022
- Full Text
- View/download PDF
41. Amyloid beta’s antimicrobial properties protect elderly mice from succumbing to infection with the neurotropic parasite Toxoplasma gondii
- Author
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McGovern, Kathryn E., primary and Koshy, Anita A, additional
- Published
- 2021
- Full Text
- View/download PDF
42. Contributors
- Author
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Abrams, Charles S., Adler, Ronald S., Agarwal, Anupam, Akin, Cem, Aksamit, Allen J., Jr., Al-Awqati, Qais, Allen, Upton D., Allos, Ban Mishu, Angus, Derek C., Appelbaum, Frederick R., Armitage, James O., Armstrong, April W., Armstrong, Deborah K., Arnaout, M. Amin, Arnold, Robert M., Aronson, Louise, Atkinson, John P., Attia, Evelyn, Auerbach, Andrew D., Ayanian, John Z., Baddour, Larry M., Baden, Lindsey R., Bailey, Thomas C., Bain, Barbara J., Bajorin, Dean F., Baloh, Robert W., Bangham, Charles R.M., Barasch, Jonathan, Barrett, Bruce, Bartholomew, John R., Bartleson, J.D., Barton, Mary B., Basner, Robert C., Bass, Adam J., Bass, Anne R., Bauman, Julie E., Bausch, Daniel G., Bayer, Arnold S., Bazarian, Jeffrey J., Bearman, Gonzalo M., Becker, Richard C., Beckham, J. David, Beckman, Joshua A., Beigel, John H., Bel, Elisabeth H., Belda, Walter, Jr., Benarroch, Eduardo E., Berger, Joseph R., Berliner, Nancy, Bernat, James L., Bessesen, Daniel H., Bibbins-Domingo, Kirsten, Biesecker, Leslie G., Biundo, Joseph J., Blankson, Joel N., Bloch, Karen C., Blom, Henk J., Boden, William E., Boivin, Guy, Bolognia, Jean, Bonomo, Robert A., Booth, Sarah L., Bosaeus, Ingvar G., Brenner, David J., Bridges, S. Louis, Jr., Brochard, Laurent, Brodsky, Robert A., Brook, Itzhak, Brown, Jennifer R., Brunetti, Enrico, Bryant, Amy E., Budge, Philip J., Buffet, Pierre A., Bushinsky, David A., Bykerk, Vivian P., Calabresi, Peter A., Calello, Diane P., Calfee, David P., Callahan, S. Todd, Camilleri, Michael, Canoso, Juan J., Cappellini, Maria Domenica, Carabello, Blase A., Carucci, Laura R., Castells, Mariana, Catherino, William H., Cederholm, Tommy E., Chalasani, Naga P., Chambers, Henry F., Chang, Larry W., Chang, Lin, Chao, Nelson J., Chatterjee, Mitali, Chaturvedi, Seemant, Chen, Lin H., C-A Chen, Sharon, Chon, Susan Y., Christiani, David C., Chu, Edward, Cieslak, Theodore J., Cioffi, George A., Clancy, Carolyn M., Clauss, Heather, Clauw, Daniel J., Clemmons, David R., Coffman, Thomas M., Cohen, David, Cohen, Jeffrey, Cohen, Myron S., Cohen, Steven P., Connors, Joseph M., Cook, Deborah J., Cook, Lucy B.M., Cooney, Kathleen A., Craigen, William J., Crandall, Jill P., Croft, Simon L., Crow, Mary K., Crump, John A., Cudkowicz, Merit E., Cunningham-Rundles, Charlotte, Dahir, Kathryn M., Damon, Inger K., Daras, Michael, Dart, Richard C., Davidson, Nancy E., Deane, Kevin D., DeAngelis, Lisa M., DeCamp, Malcolm M., DeLoughery, Thomas G., Rio, Carlos del, De Luca, Gabriele C., Denning, David W., Deuster, Patricia A., DeZern, Amy E., Dhatariya, Ketan K., Diasio, Robert B., Diemert, David J., Digre, Kathleen B., Dilsizian, Vasken, Dionne, Jodie A., Di Paola, Jorge, Dispenzieri, Angela, Dogra, Sunil, Doroshow, James H., Douglas, John M., Jr., Drazen, Jeffrey M., Drekonja, Dimitri, Dubberke, Erik R., DuBeau, Catherine E., Dumler, J. Stephen, Duvic, Madeleine, Ebi, Kristie, Edwards, Kathryn M., Edwards, N. Lawrence, Eikelboom, John W., Einhorn, Lawrence H., Elliott, Perry M., Emanuel, Ezekiel J., Falagas, Matthew E., Falk, Gary W., Fang, James C., Farley, Monica M., Feder, Gene, Feller-Kopman, David J., McDonald File, Thomas, Jr., Fishman, Glenn I., Flack, John M., Fleckenstein, James M., Fleisher, Lee A., Flint, Paul W., Fogel, Evan L., Fontana, Robert J., Forsmark, Chris E., Fournier, Pierre-Edouard, Fowler, Vance G., Jr., Franco, Manuel A., Fraser, Victoria J., Freeman, Roy, Freund, Karen M., Froberg, Blake A., Gallagher, Patrick G., Gandhi, Monica, Gandhi, Rajesh T., Ganz, Leonard, Garan, Hasan, Garcia-Tsao, Guadalupe, Geisler, William M., Gelfand, Joel M., George, Tony P., Gepstein, Lior, Gertz, Morie A., Ghanem, Khalil G., Gharavi, Ali G., Ghossein, Cybele, Gill, Christopher J., Ginsburg, Geoffrey S., Glesby, Marshall J., Gnann, John W., Jr., Goldman, David L., Goldman, Lee, Goldstein, Larry B., Gordon, Anthony C., Gotlib, Jason, Gotuzzo, Eduardo, Grasemann, Hartmut, Green-McKenzie, Judith, Greenberg, Harry B., Greenberg, Steven A., Greer, David M., Greysen, S. Ryan, Griffin, Marie R., Griggs, Robert C., Grossman, Daniel, Guay-Woodford, Lisa M., Gulick, Roy M., Haake, David A., Hagman, Melissa M., Hagspiel, Klaus D., Harris, Raymond C., Havers, Fiona P., Heath, Elisabeth I., Hecht, Frederick M., Hensrud, Donald D., Hess, Jeremy, Hewlett, Erik L., Hift, Richard J., Hill, David R., Hill, Nicholas S., Hillyer, Christopher D., Hirsch, Hans H., Hoeper, Marius M., Hoit, Brian D., Holers, V. Michael, Holland, Steven M., Hollenberg, Anthony N., Hollenberg, Steven M., Howard, Jo, Hunter, David J., Hussain, Khalid, Iannuzzi, Michael C., Inman, Robert D., Inouye, Sharon K., Ison, Michael G., Jen, Joanna C., Jensen, Dennis M., Jensen, Michael D., Jensen, Robert T., Johnston, S. Claiborne, Jones, Robin L., Jordan, Richard C., Kahi, Charles J., Kaiser, Laurent, Kaminski, Henry J., Kamya, Moses R., Kao, Louise W., Kaplan, Steven A., Kastner, Daniel L., Katzka, David A., Katzman, Debra K., Kaushansky, Kenneth, Kaye, Keith S., Keating, Armand, Kelley, Robin K., Kennedy, Richard B., Khuri, Fadlo R., Kim, Rose, Kirchhoff, Louis V., Kirking, Hannah, Kirtane, Ajay J., Kishnani, Priya S., Klausner, Jeffrey D., Klion, Amy D., Klompas, Michael, Knopman, David S., Ko, Christine J., Kodali, Susheel, Kontoyiannis, Dimitrios P., Koppel, Barbara S., Korenblat, Kevin M., Korf, Bruce R., Kortepeter, Mark G., Koshy, Anita A., Kottilil, Shyamasundaran, Kovacs, Joseph A., Kovacs, Thomas O., Kowdley, Kris V., Kraft, Monica, Kramer, Christopher M., Krasnewich, Donna M., Kraus, William E., Krause, Peter J., Kroger, Andrew T., Kroshinsky, Daniela, Kuemmerle, John F., Kuipers, Ernst J., Kutner, Jean S., Laheru, Daniel, Lampert, Rachel, Landefeld, C. Seth, Landovitz, Raphael J., Landry, Donald W., Lange, Richard A., Lee, Hochang B., Lee, Nelson, Levey, Andrew S., Levine, Stephanie M., Lichtenstein, Gary R., Liebmann, Jeffrey M., Liebschutz, Jane M., Lim, Henry W., Lima, Aldo A.M., Limaye, Ajit P., Limdi, Nita A., Link, Mark S., Liu, Catherine, Lloyd-Jones, Donald M., Lopez, Fred A., Louie, Arnold, Lyness, Jeffrey M., MacKenzie, C. Ronald, MacLennan, Calman A., MacMillan, Harriet L., Madoff, Robert D., Maher, Jacquelyn, Maier, Lisa A., Maldarelli, Frank, Malhotra, Atul, Manary, Mark J., Marcos, Luis A., Marelli, Ariane J., Marks, Andrew R., Marschall, Jonas, Martin, Paul, Martinez, Fernando J., Mason, Joel B., Masur, Henry, Mathers, Amy J., Matthay, Michael A., McCool, F. Dennis, McInnes, Iain B., McLaughlin, Vallerie, McMichael, Amy, McMurray, John J.V., McQuaid, Kenneth R., Mead, Paul S., Means, Robert T., Jr., Melia, Michael T., Mellinghoff, Ingo K., Melton, Genevieve B., Merrick, Samuel T., Miceli, Marisa H., Michel, Marc, Mokdad, Ali H., Moy, Ernest, Mukherjee, Debabrata, Murr, Andrew H., Myerburg, Robert J., Nadeau, Kari C., Nath, Avindra, Neal-Perry, Genevieve, Neilson, Eric G., Nelson, Christina A., Nelson, David B., Nelson, Lewis S., Nestler, Eric J., Neuzil, Kathleen M., Nieman, Lynnette K., Niven, Alexander S., O’Connor, Christopher M., O’Connor, Francis G., O’Connor, Patrick G., O’Donnell, Anne E., O’Donnell, James S., Oh, Jae K., Okun, Michael S., O’Leary, Sean T., Olgin, Jeffrey E., Olivier, Kenneth N., Olivotto, Iacopo, Olsen, Nancy J., Orenstein, Walter A., Ortel, Thomas L., O’Shea, John J., Osmon, Douglas R., Ostrem, Jill L., Ostrosky-Zeichner, Luis, Otto, Catherine M., Ottolini, Martin G., Ovsyannikova, Inna G., Pappas, Peter G., Park, Ben Ho, Patel, Robin, Patterson, Thomas F., Pawlotsky, Jean-Michel, Payne, Thomas H., Pearce, Elizabeth N., Pearson, Richard D., Perl, Trish M., Petersen, Brett W., Petri, William A., Jr., Pfeffer, Marc A., Philips, Jennifer A., Pisetsky, David S., Pletcher, Steven D., Plumb, Ian D., Poland, Gregory A., Powell, Frank, Pyeritz, Reed E., Quinn, Thomas C., Racaniello, Vincent, Radhakrishnan, Jai, Radich, Jerald, Rafailidis, Petros I., Raghu, Ganesh, Ragni, Margaret V., Rahman, Proton, Rajkumar, S. Vincent, Ralston, Stuart H., Raoult, Didier, Reboli, Annette C., Reddy, K. Rajender, Redelmeier, Donald A., Redlich, Carrie A., Reilly, John, Reller, Megan E., Reno, Hilary E.L., Resnick, Neil M., Rice, Louis B., Roach, E. Steve, Robinson, Jennifer G., Rogatsky, Inez, Rogers, Joseph G., Rolain, Jean-Marc, Rollins, Barrett J., Romero, José R., Rosen, Jennifer B., Rosenthal, Philip J., Russell, James A., Rustgi, Anil K., Safer, Joshua D., Saini, Sarbjit S., Salmon, Jane E., Salvana, Edsel Maurice T., Santoro, Nanette, Santucci, Peter A., Sarnak, Mark J., Savage, Kerry J., Savard, Patrice, Sawka, Michael N., Scanlon, Paul D., Schafer, Andrew I., Schiff, Manuel, Schilsky, Michael L., Schneider, Thomas Rudolf, Schooley, Robert T., Schriger, David L., Schuchter, Lynn M., Schwartz, Lawrence B., Seas, Carlos, Seifert, Steven A., Seifter, Julian Lawrence, Selcen, Duygu, Selim, Magdy, Semrad, Carol E., Sepulveda, Jorge, Shaw, Pamela J., Shaz, Beth H., Sheridan, Robert L., Sherman, Stuart, Shojania, Kaveh G., Shopsin, Bo, Shy, Michael E., Sidransky, Ellen, Sifri, Costi D., Siliciano, Robert F., Simel, David L., Skorecki, Karl, Slawski, Barbara A., Slutsky, Arthur S., Smetana, Gerald W., Smith, A. Gordon, Smith, Stephen R., Southwick, Frederick S., Spiegel, Allen M., Spiera, Robert, Spinola, Stanley M., Spong, Catherine Y., Stabler, Sally P., Stark, Paul, St. Clair, E. William, Steiner, Theodore S., Stephens, David S., Stevens, David A., Stevens, Dennis L., Stokes, M. Barry, Stoller, James K., Stone, John H., Stone, Richard M., Su, Edwin P., Swerdloff, Ronald S., Swygard, Heidi, Sykes, Megan, Talbot, H. Keipp, Tamimi, Rulla M., Tanofsky-Kraff, Marian, Tarlo, Susan M., Taylor, Stephanie N., Teirstein, Paul S., Telford, Sam R., III, Thakker, Rajesh V., Therrien, Judith, Thompson, George R., III, Tormoehlen, Laura, Tosti, Antonella, Trehan, Indi, Umpierrez, Guillermo E., Valeri, Anthony Michael, Varga, John, Vaughn, Bradley V., Venook, Alan P., Verbalis, Joseph G., Vose, Julie M., Wachter, Robert M., Walsh, B. Timothy, Walsh, Edward E., Walsh, Thomas J., Walston, Jeremy D., Walter, Roland B., Wang, Christina, Wang, Kenneth K., Ware, Lorraine B., Warren, Cirle A., Watkins, Paul B., Weber, Thomas J., Weimer, Louis H., Weinberg, Geoffrey A., Weinstein, Robert S., Weiss, Roger D., Weiss, Roy E., Weitz, Jeffrey I., Welt, Frederick G.P., Wenzel, Richard P., Werth, Victoria P., West, Sterling G., White, A. Clinton, Jr., White, Christopher J., White, Julian, White, Perrin C., Whitley, Richard J., Whyte, Michael P., Wiebe, Samuel, Wiener-Kronish, Jeanine P., Wilber, David J., Wilcox, Mark H., Winikoff, Beverly, Winter, Jane N., Wittink, Marsha N., Wolff, Tracy A., Wolin, Edward M., Wormser, Gary P., Yancy, Clyde W., Young, Neal S., Young, Vincent B., Young, William F., Jr., Yu, Alan S.L., Zimetbaum, Peter, and Zucker, Jane R.
- Published
- 2024
- Full Text
- View/download PDF
43. Free-Living Amebae
- Author
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Koshy, Anita A., primary, Blackburn, Brian G., additional, and Singh, Upinder, additional
- Published
- 2015
- Full Text
- View/download PDF
44. Contributors
- Author
-
Aagaard, Kjersti, primary, Abrahamian, Fredrick M., additional, Allos, Ban Mishu, additional, Andes, David R., additional, Aoki, Fred Y., additional, Apicella, Michael A., additional, Ard, Kevin L., additional, Arias, Cesar A., additional, Aronoff, David M., additional, Augenbraun, Michael H., additional, Averhoff, Francisco, additional, Azar, Dimitri T., additional, Baddour, Larry M., additional, Baden, Lindsey R., additional, Baker, Carol J., additional, Ballard, Ronald C., additional, Barber, Gerard R., additional, Barnes, Scott D., additional, Barouch, Dan H., additional, Barrett, Alan D., additional, Barshak, Miriam Baron, additional, Basavaraju, Sridhar V., additional, Batteiger, Byron E., additional, Baum, Stephen G., additional, Bayer, Arnold S., additional, Beckham, J. David, additional, Beekmann, Susan E., additional, Bell, Beth P., additional, Bennett, John E., additional, Bente, Dennis A., additional, Berbari, Elie F., additional, Berman, Jonathan, additional, Bertino, Joseph S., additional, Bhimraj, Adarsh, additional, Birdsall, Holly H., additional, Bisno, Alan L., additional, Blackburn, Brian G., additional, Blanton, Lucas S., additional, Blaser, Martin J., additional, Bleck, Thomas P., additional, Blijlevens, Nicole M.A., additional, Bobak, David A., additional, Bonnez, William, additional, Boothroyd, John C., additional, Borio, Luciana L., additional, Bosque, Patrick J., additional, Bower, John, additional, Bradsher, Robert W., additional, Brook, Itzhak, additional, Brown, Kevin E., additional, Brown, Patricia D., additional, Brown-Elliott, Barbara A., additional, Bruhn, Roberta L., additional, Bryant, Amy E., additional, Burd, Eileen M., additional, Burns, Jane C., additional, Bush, Larry M., additional, Calderwood, Stephen B., additional, Cano, Luz Elena, additional, Carpenter, Charles C.J., additional, Caserta, Mary T., additional, Castagnola, Elio, additional, Chaisson, Richard E., additional, Chambers, Henry F., additional, Chapman, Stephen J., additional, Chappell, James D., additional, Chen, Lea Ann, additional, Chen, Sharon C-A, additional, Chow, Anthony W., additional, Clark, Rebecca A., additional, Cohen, Jeffrey I., additional, Cohen, Myron S., additional, Cohen-Poradosu, Ronit, additional, Cohn, Susan E., additional, Connors, Mark, additional, Corey, Lawrence, additional, Cottrell, Mackenzie L., additional, Cover, Timothy L., additional, Cox, Heather L., additional, Craig, William A., additional, Crossley, Kent B., additional, Crumpacker, Clyde S., additional, Curran, James W., additional, Currie, Bart J., additional, D'Agata, Erika, additional, Damon, Inger K., additional, Darouiche, Rabih O., additional, DeBiasi, Roberta L., additional, Deepe, George S., additional, del Rio, Carlos, additional, Delemos, Andrew S., additional, DeLeo, Frank R., additional, DeMuri, Gregory P., additional, Densen, Peter, additional, Dermody, Terence S., additional, Dewar, Robin, additional, Diaz, James H., additional, Dieffenbach, Carl W., additional, Dienstag, Jules L., additional, Doi, Yohei, additional, Dolin, Raphael, additional, Donnelly, J. Peter, additional, Donnenberg, Michael S., additional, Donowitz, Gerald R., additional, Dormitzer, Philip R., additional, Drake, James M., additional, Dumler, J. Stephen, additional, Dummer, J. Stephen, additional, DuPont, Herbert L., additional, Durack, David T., additional, Durand, Marlene L., additional, Edelstein, Paul H., additional, Edmond, Michael B., additional, Edwards, John E., additional, Edwards, Morven S., additional, Eliopoulos, George M., additional, Ellison, Richard T., additional, Endy, Timothy P., additional, Engleberg, N. Cary, additional, Erdem, Hakan, additional, Ernst, Joel D., additional, Ernst, Peter B., additional, Fairhurst, Rick M., additional, Fairley, Jessica K., additional, Falkow, Stanley, additional, Falsey, Ann R., additional, Fauci, Anthony S., additional, Fekete, Thomas, additional, Fey, Paul D., additional, Fine, Steven M., additional, Fitzgerald, Daniel W., additional, Flores, Anthony R., additional, Forster, Derek, additional, Fowler, Vance G., additional, Freedman, David O., additional, Friedlander, Arthur M., additional, Galgiani, John N., additional, Gallin, John I., additional, Gallo, Robert C., additional, Gandhi, Tejal N., additional, Garrett, Wendy S., additional, Gaydos, Charlotte A., additional, Geisbert, Thomas W., additional, Gelfand, Jeffrey A., additional, Gelone, Steven P., additional, Gerding, Dale N., additional, Gershon, Anne A., additional, Gilsdorf, Janet R., additional, Goldstein, Ellie J.C., additional, Gordin, Fred M., additional, Graman, Paul S., additional, Grayson, M. Lindsay, additional, Greene, Jeffrey Bruce, additional, Griffin, Patricia M., additional, Griffith, David E., additional, Guerrant, Richard L., additional, Gul, H. Cem, additional, Haake, David A., additional, Haas, David W., additional, Haines, Charles, additional, Hall, Caroline Breese, additional, Hallak, Joelle, additional, Halperin, Scott A., additional, Hammerschlag, Margaret R., additional, Haque, Rashidul, additional, Harris, Jason B., additional, Hawkins, Claudia, additional, Hay, Roderick J., additional, Hedberg, Craig W., additional, Henderson, David K., additional, Henderson, Donald A., additional, High, Kevin P., additional, Hill, Adrian V.S., additional, Hill, David R., additional, Hinman, Alan R., additional, Hirsch, Martin S., additional, Hodowanec, Aimee, additional, Hohl, Tobias M., additional, Holland, Steven M., additional, Holzman, Robert S., additional, Hook, Edward W., additional, Hooper, David C., additional, Hooton, Thomas M., additional, Horowitz, Harold W., additional, Horsburgh, C. Robert, additional, Horton, James M., additional, Hospenthal, Duane R., additional, Hsueh, Kevin, additional, Hughes, James M., additional, Hynes, Noreen A., additional, Iovine, Nicole M., additional, Iredell, Jonathan R., additional, Ison, Michael G., additional, Janda, J. Michael, additional, Janoff, Edward N., additional, Johannsen, Eric C., additional, Kashuba, Angela D.M., additional, Kasper, Dennis L., additional, Kaye, Donald, additional, Kaye, Keith S., additional, Kaye, Kenneth M., additional, Kazura, James W., additional, Keystone, Jay S., additional, Khabbaz, Rima, additional, Khan, David A., additional, Khudyakov, Yury, additional, Kim, Rose, additional, King, Charles H., additional, Kirchhoff, Louis V., additional, Klein, Jerome O., additional, Klompas, Michael, additional, Knoll, Bettina M., additional, Knowlton, Kirk U., additional, Koehler, Jane E., additional, Kohlhoff, Stephan A., additional, Könönen, Eija, additional, Kontoyiannis, Dimitrios P., additional, Koralnik, Igor J., additional, Korpe, Poonum S., additional, Koshy, Anita A., additional, Kovacs, Joseph A., additional, Kozarsky, Phyllis, additional, Krieger, John, additional, Kroger, Andrew T., additional, Kuehnert, Matthew J., additional, Kumar, Nalin M., additional, Kuruvilla, Merin Elizabeth, additional, LaRocque, Regina C., additional, Leggett, James E., additional, Legido-Quigley, Helena, additional, Levett, Paul N., additional, Levine, Donald P., additional, Levison, Matthew E., additional, Levitt, Alexandra, additional, Lewis, Russell E., additional, Liles, W. Conrad, additional, Lima, Aldo A.M., additional, Limaye, Ajit P., additional, Lipkin, W. Ian, additional, Litman, Nathan, additional, Lorber, Bennett, additional, Luna, Ruth Ann, additional, MacDougall, Conan, additional, Roy, Rob, additional, Mackowiak, Philip A., additional, Madoff, Lawrence C., additional, Magill, Alan J., additional, Maguire, James H., additional, Maldarelli, Frank, additional, Markoff, Lewis, additional, Marrazzo, Jeanne M., additional, Marrie, Thomas J., additional, Marth, Thomas, additional, Martin, David H., additional, Martin, Gregory J., additional, Marty, Francisco M., additional, Maslow, Melanie Jane, additional, Masur, Henry, additional, Mawle, Alison, additional, Mayer, Kenneth H., additional, McBride, John T., additional, McCarthy, James S., additional, McCormack, William M., additional, McGowan, Catherine C., additional, McIntosh, Kenneth, additional, Mead, Paul S., additional, Mikulska, Malgorzata, additional, Miller, Robert F., additional, Miller, Samuel I., additional, Mitchell, David H., additional, Modlin, John F., additional, Mody, Rajal K., additional, Moellering, Robert C., additional, Moffa, Matthew, additional, Moir, Susan, additional, Montoya, José G., additional, Moore, Thomas A., additional, Moreillon, Philippe, additional, Morris, J. Glenn, additional, Morse, Caryn Gee, additional, Moseley, Robin, additional, Munford, Robert S., additional, Murphy, Edward L., additional, Murphy, Timothy F., additional, Murray, Barbara E., additional, Murray, Clinton K., additional, Murray, Patrick R., additional, Musher, Daniel M., additional, Nagel, Jerod L., additional, Nannini, Esteban C., additional, Narezkina, Anna, additional, Nash, Theodore E., additional, Nauseef, William M., additional, Nayak, Jennifer L., additional, Neill, Marguerite A., additional, O'Donnell, Judith A., additional, Ohl, Christopher A., additional, Okhuysen, Pablo C., additional, Onderdonk, Andrew B., additional, Opal, Steven M., additional, Orenstein, Walter A., additional, Osmon, Douglas R., additional, Osterholm, Michael T., additional, Ostroff, Stephen M., additional, Oxman, Michael N., additional, Paessler, Slobodan, additional, Page, Andrea V., additional, Pai, Manjunath P., additional, Palmore, Tara N., additional, Palraj, Raj, additional, Pappas, Peter G., additional, Pasternack, Mark S., additional, Patterson, Thomas F., additional, Pavan-Langston, Deborah, additional, Pegues, David A., additional, Penn, Robert L., additional, Perfect, John R., additional, Perlman, Stanley, additional, Petersen, Brett W., additional, Peterson, Phillip K., additional, Petri, William A., additional, Petti, Cathy A., additional, Philips, Jennifer A., additional, Philley, Julie V., additional, Phillips, Michael, additional, Pickering, Larry K., additional, Piot, Peter, additional, Pogue, Jason M., additional, Pop-Vicas, Aurora, additional, Portal-Celhay, Cynthia, additional, Powers, John H., additional, Price, Richard N., additional, Que, Yok-Ai, additional, Radolf, Justin D., additional, Ram, Sanjay, additional, Raoult, Didier, additional, Ravdin, Jonathan I., additional, Ray, Stuart C., additional, Reboli, Annette C., additional, Reitz, Marvin S., additional, Relman, David A., additional, Renault, Cybèle A., additional, Restrepo, Angela, additional, Rex, John H., additional, Rhee, Elizabeth G., additional, Roberts, Norbert J., additional, Romero, José R., additional, Rothman, Alan L., additional, Roy, Craig R., additional, Ruoff, Kathryn L., additional, Rupp, Mark E., additional, Rupprecht, Charles E., additional, Russo, Thomas A., additional, Rutala, William A., additional, Ryan, Edward T., additional, Safdar, Amar, additional, Sajadi, Mohammad M., additional, Salazar, Juan C., additional, Sarria, Juan Carlos, additional, Savoia, Maria C., additional, Sax, Paul E., additional, Scheld, W. Michael, additional, Schiffer, Joshua T., additional, Schlossberg, David, additional, Schneider, Thomas, additional, Schuchat, Anne, additional, Schwebke, Jane R., additional, Sears, Cynthia L., additional, Segal, Leopoldo N., additional, Sendi, Parham, additional, Sepkowitz, Kent A., additional, Septimus, Edward J., additional, Seregin, Alexey, additional, Shulman, Stanford T., additional, Siberry, George K., additional, Siddiqi, Omar K., additional, Sifri, Costi D., additional, Simberkoff, Michael S., additional, Simonetti, Francesco R., additional, Singh, Kamaljit, additional, Singh, Nina, additional, Singh, Upinder, additional, Sinner, Scott W., additional, Sivapalasingam, Sumathi, additional, Slater, Leonard N., additional, Smulian, A. George, additional, Sobel, Jack D., additional, Sohail, M. Rizwan, additional, Soper, David E., additional, Sorrell, Tania C., additional, Steckelberg, James M., additional, Steere, Allen C., additional, Steigbigel, Neal H., additional, Steinberg, James P., additional, Stephens, David S., additional, Sterling, Timothy R., additional, Stevens, David A., additional, Stevens, Dennis L., additional, Strahilevitz, Jacob, additional, Stratton, Charles W., additional, Suffredini, Anthony F., additional, Suh, Kathryn N., additional, Sulkowski, Mark S., additional, Swartz, Morton N., additional, Talbot, Thomas R., additional, Tan, C. Sabrina, additional, Tan, Ming, additional, Thio, Chloe Lynne, additional, Thomas, David L., additional, Thomas, Lora D., additional, Thomas, Stephen J., additional, Thorner, Anna R., additional, María Tobón, Angela, additional, Tramont, Edmund C., additional, Treanor, John J., additional, Trubiano, Jason, additional, Tsibris, Athe M.N., additional, Tunkel, Allan R., additional, Turner, Ronald B., additional, Tyler, Kenneth L., additional, Uluer, Ahmet, additional, van de Beek, Diederik, additional, van der Velden, Walter J.F.M., additional, Vannier, Edouard G., additional, Van, Trevor C., additional, Versalovic, James, additional, Viscoli, Claudio, additional, Wald, Ellen R., additional, Waldor, Matthew K., additional, Walker, David H., additional, Wallace, Richard J., additional, Walsh, Edward E., additional, Walsh, Stephen R., additional, Walzer, Peter D., additional, Wanke, Christine A., additional, Warren, Cirle A., additional, Washburn, Ronald G., additional, Waters, Valerie, additional, Weber, David J., additional, Weiden, Michael D., additional, Weinberg, Geoffrey A., additional, Weisdorf, Daniel J., additional, Weiss, Louis M., additional, Welch, David F., additional, Wellems, Thomas E., additional, Wenzel, Richard P., additional, Wharton, Melinda, additional, White, A. Clinton, additional, Whitley, Richard J., additional, Wilson, Walter R., additional, Wortmann, Glenn W., additional, Wright, William F., additional, Young, Jo-Anne H., additional, Young, Vincent B., additional, Yun, Nadezhda, additional, Zimmerli, Werner, additional, Zinner, Stephen H., additional, and Zurlo, John J., additional
- Published
- 2015
- Full Text
- View/download PDF
45. IFN-γ stimulated murine and human neurons mount anti-parasitic defenses against the intracellular parasiteToxoplasma gondii
- Author
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Chandrasekaran, Sambamurthy, primary, Kochanowsky, Joshua A., additional, Merritt, Emily F., additional, Lagas, Joseph S., additional, Swannigan, Ayesha, additional, and Koshy, Anita A., additional
- Published
- 2021
- Full Text
- View/download PDF
46. Profiling the Peripheral Blood Immune Cell Repertoire in Large-B Cell Lymphoma Patients Treated with CD19 CAR-T
- Author
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Cheloni, Giulia, primary, Kanata, Eleni, additional, Stroopinsky, Dina, additional, Karagkouni, Dimitra, additional, Liegel, Jessica J., additional, Torres, Daniela, additional, Hauser, Joshua, additional, Bindal, Poorva, additional, Koshy, Anita G., additional, Pita-Juarez, Yered, additional, Bot, Adrian, additional, Mattie, Mike, additional, Chou, Justin, additional, Rosenblatt, Jacalyn, additional, Avigan, David, additional, and Vlachos, Ioannis, additional
- Published
- 2021
- Full Text
- View/download PDF
47. Treatment with DC/AML Fusion Vaccine and CD3xCD123 Bi-Specific T-Cell Engager (CD123-CODV-TCE) for Treatment of Acute Myeloid Leukemia
- Author
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Stroopinsky, Dina, primary, Koshy, Anita G., additional, Liegel, Jessica J., additional, Nahas, Myrna, additional, Cheloni, Giulia, additional, Hauser, Joshua, additional, Torres, Daniela, additional, Bindal, Poorva, additional, Rahimian, Maryam, additional, Bisharat, Lina, additional, Fraenkel, Paula, additional, Yildirim, Ozlem, additional, Bonnevaux, Helene, additional, Guerif, Stephane, additional, Kufe, Donald, additional, Rosenblatt, Jacalyn, additional, and Avigan, David, additional
- Published
- 2021
- Full Text
- View/download PDF
48. Phase II Clinical Trial of Abatacept for Steroid-Refractory Chronic Graft Versus Host Disease
- Author
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Koshy, Anita G., primary, Kim, Haesook T., additional, Stroopinsky, Dina, additional, Liegel, Jessica J., additional, Arnason, Jon E., additional, Ho, Vincent T., additional, Antin, Joseph H., additional, Joyce, Robin M., additional, Cutler, Corey, additional, Gooptu, Mahasweta, additional, Nikiforow, Sarah, additional, Logan, Emma K., additional, Elavalakanar, Pavania, additional, Stephenson, Susan, additional, El Banna, Hassan, additional, Bindal, Poorva, additional, Cheloni, Giulia, additional, Avigan, David, additional, Soiffer, Robert J., additional, and Rosenblatt, Jacalyn, additional
- Published
- 2021
- Full Text
- View/download PDF
49. Synergism between CAR-T Cells and a Personalized Tumor Vaccine in Hematological Malignances
- Author
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Cheloni, Giulia, primary, Capelletti, Marzia, additional, Torres, Daniela, additional, Bindal, Poorva, additional, Liegel, Jessica J., additional, Stroopinsky, Dina, additional, Bisharat, Lina, additional, Rahimian, Maryam, additional, Yoo, Seo Yeon, additional, Hauser, Joshua, additional, Koshy, Anita G., additional, Dufort, Kenel, additional, Clohessy, John G., additional, Kufe, Donald, additional, Themeli, Maria, additional, Rosenblatt, Jacalyn, additional, Sadelain, Michel, additional, and Avigan, David, additional
- Published
- 2021
- Full Text
- View/download PDF
50. Post-Transplant Vaccination with a Personalized Dendritic Cell/AML Fusion Cell Vaccine for Prevention of Relapse
- Author
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Liegel, Jessica J., primary, Bindal, Poorva, additional, Stone, Richard M., additional, Soiffer, Robert J., additional, Stroopinsky, Dina, additional, Cheloni, Giulia, additional, Bisharat, Lina, additional, Torres, Daniela, additional, Rahimian, Maryam, additional, Yoo, Seo Yeon, additional, Logan, Emma K., additional, Elavalakanar, Pavania, additional, El Banna, Hassan, additional, Hauser, Joshua, additional, Koshy, Anita G., additional, Romee, Rizwan, additional, Ho, Vincent T., additional, Neuberg, Donna S., additional, Liu, Yiwen, additional, Mendez, Lourdes M., additional, Dias, Ajoy L., additional, Ebert, Benjamin L., additional, Kufe, Donald, additional, Avigan, David, additional, and Rosenblatt, Jacalyn, additional
- Published
- 2021
- Full Text
- View/download PDF
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