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280 results on '"Kosenko, E. A."'

20. Assessment of the stress-strain state of machine structural elements made of polymer composite materials with a hybrid matrix by numerical simulation

Author

Kosenko E., Nelyub V., and Zorin V.

Subjects
Environmental sciences, GE1-350
Abstract

The expansion of the fields of application of polymer composite materials (PCM) requires the development of their new compositions, structures, and molding methods. One of the most difficult tasks in the design of PCM products is the selection or development of a polymer matrix that meets a number of technological and operational requirements. The addition of components forming an independent conditionally liquid phase to the composition of the PCM matrix makes it possible to change the set of properties of the composite and ensure its high crack resistance. The paper presents the results of evaluating the stress-strain state of model samples of carbon fiber reinforced plastic with an organosilicon polymer material that forms a hybrid matrix with the base material of the binder. Modeling was carried out for cases of using organosilicon material with low and high modulus of elasticity. Also, modeling of a front-end loader bucket made using carbon fiber with the considered hybrid matrix was performed. The simulation results showed that the use of PCM with organosilicon material in the manufacture of a product can significantly reduce its weight and provide a sufficient margin of safety.

Published
2023
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30. List of Contributors

Author

Beloglazov, D., primary, Finaev, V., additional, Guzik, V., additional, Kosenko, E., additional, Krukhmalev, V., additional, Medvedev, M., additional, Pereverzev, V., additional, Pshikhopov, V., additional, Pyavchenko, A., additional, Saprykin, R., additional, Shapovalov, I., additional, and Soloviev, V., additional

Published
2017
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35. Is NMDA-Receptor-Mediated Oxidative Stress in Mitochondria of Peripheral Tissues the Essential Factor in the Pathogenesis of Hepatic Encephalopathy?

Author

Kosenko E, Tikhonova L, Alilova G, and Montoliu C

Abstract

BACKGROUND: Hepatic encephalopathy (HE) is a neuropsychiatric syndrome of increased ammonia-mediated brain dysfunction caused by impaired hepatic detoxification or when the blood bypasses the liver. Ammonia-activated signal transduction pathways of hyperactivated NMDA receptors (NMDAR) are shown to trigger a cascade of pathological reactions in the brain, leading to oxidative stress. NMDARs outside the brain are widely distributed in peripheral tissues, including the liver, heart, pancreas, and erythrocytes. To determine the contribution of these receptors to ammonia-induced oxidative stress in peripheral tissues, it is relevant to investigate if there are any ammonia-related changes in antioxidant enzymes and free radical formation and whether blockade of NMDARs prevents these changes.; METHODS: Hyperammonemia was induced in rats by ammonium acetate injection. Oxidative stress was measured as changes in antioxidant enzyme activities and O2- and H2O2 production by mitochondria isolated from the tissues and cells mentioned above. The effects of the NMDAR antagonist MK-801 on oxidative stress markers and on tissue ammonia levels were evaluated.; RESULTS: Increased ammonia levels in erythrocytes and mitochondria isolated from the liver, pancreas, and heart of hyperammonemic rats are shown to cause tissue-specific oxidative stress, which is prevented completely (or partially in erythrocyte) by MK-801.; CONCLUSIONS: These results support the view that the pathogenesis of HE is multifactorial and that ammonia-induced multiorgan oxidative stress-mediated by activation of NMDAR is an integral part of the disease and, therefore, the toxic effects of ammonia in HE may be more global than initially expected.

Published
2022

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