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KOSECKA, Katarzyna, RUDZIŃSKI, Patryk, CIEŚLIK, Aleksandra, JARGIEŁO, Anna, KOSIERADZKA, Karolina, ADAMOWICZ, Dominik, STAŃCZYK, Justyna, ŁOPUSZYŃSKA, Inga, WOSIŃSKA, Alicja and MELIKSETIAN, Astrik. The potential of using exosomes in modern medicine. Journal of Education, Health and Sport. 2023;25(1):120-133.eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.25.01.011 https://apcz.umk.pl/JEHS/article/view/44854 https://zenodo.org/record/8173588 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2023; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 30.06.2023. Revised: 20.07.2023. Accepted: 20.07.2023. Published: 25.07.2023. The potential of using exosomes in modern medicine Katarzyna Kosecka The National Institute of Medicine of the Ministry of Interior and Administration, Wołoska 137, 02-507 Warszawa https://orcid.org/0009-0001-8434-7030 Patryk Rudziński Orłowski Hospital, ul. Czerniakowska 231, 00-416 Warszawa https://orcid.org/0000-0003-4709-2187 Aleksandra Cieślik Praski Hospital in Warsaw, Aleja Solidarności 67, 03-401 Warszawa https://orcid.org/0009-0007-0272-8045 Anna Jargieło https://orcid.org/0009-0008-9300-4655 Karolina Kosieradzka Praski Hospital, Aleja Solidarności 67, 03-401 Warszawa https://orcid.org/0000-0002-2446-6396 Dominik Adamowicz University Clinical Centre of the Medical University of Warsaw, Banacha 1a, 02-097 Warszawa https://orcid.org/0009-0007-0386-9392 Justyna Stańczyk National Geriatrics, Rheumatology and Rehabilitation Institute, name of prof. Eleonora Reicher in Warsaw, Spartańska 1, 02-637 Warszawa https://orcid.org/0000-0002-6004-4406 Inga Łopuszyńska The National Institute of Medicine of the Ministry of Interior and Administration, Wołoska 137, 02-507 Warszawa https://orcid.org/0000-0002-0002-9917 Alicja Wosińska Marshal Józef Piłsudski Memorial Hospital in Płońsk, Henryka Sienkiewicza 7, 09-100 Płońsk https://orcid.org/0009-0000-8712-6148 Astrik Meliksetian The National Institute of Medicine of the Ministry of Interior and Administration, Wołoska 137, 02-507 Warszawa https://orcid.org/0000-0002-7014-4638 Abstract Introduction and purpose of the work:The purpose of this article is to determine the potential for the application of exosomes in modern medicine, inferring from research directions in world literature. Among other things, this paper considers some of the most recent work in the fields of aesthetic medicine, dermatology and transplantation. Methodology and materials: The search was conducted using PubMed, Google Scholarship, Scopus and Web of Science databases. The search strategy was based on the following terms: exosomes, regenerative medicine, dermatology. The variety of available scientific works on exosomes raises the question in which of the fields of medicine they will be used the fastest and/or most commonly. Given that a significant part of research focuses on their use in skin treatments, it can be expected that it will be dermatology and/or aesthetic medicine, given its exceptional openness to the implementation of new techniques and the constant search for new solutions that allow physiologically or optically to oppose aging. In addition, the use of exosomes is characterized by a relatively low risk of life-threatening complications or permanent damage to health. However, the potential applications of exosomes in other fields of medicine should not be underestimated. Therefore, it can be expected that procedures and therapies using exosomes will also be developed and implemented independently in transplantology, cardiology, or other fields that can use exosomes as drug carriers or markers for early detection of complications or diseases. Keywords: exosomes, regenerative medicine, aesthetic medicine, transplantation, cardiovascular disease. Potencjał zastosowania egzosomów we współczesnej medycynie. Abstrakt Wprowadzenie i cel pracy: Celem pracy jest określenie potencjału zastosowania egzosomów we współczesnej medycynie, w ramach wnioskowania na podstawie kierunków badań naukowych w światowej literaturze. W niniejszym artykule uwzględniono między innymi jedne z najnowszych prac w dziedzinie medycyny estetycznej, dermatologii i transplantologii. Metodyka i materiały: Wyszukiwanie zostało przeprowadzone za pomocą baz danych PubMed, Google Scholarship, Scopus, Web of Science. Strategia wyszukiwania opierała się na następujących terminach: egzosomy, medycyna regeneracyjna, dermatologia. Słowa klucze: Egzosomy, medycyna regeneracyjna,medycyna estetyczna, transplantologia, choroby sercowo-naczyniowe.

Acute central nervous system disorders are a direct threat to life and should therefore be recognized and treated as soon as possible. Brain damage is one of the most common causes of death. Detailed below are detailed symptomatic disease units designed to facilitate rapid diagnosis of the disorder and to decide whether to transport the patient to the appropriate medical center as soon as possible. Diagnostic options for diagnosing a disease such as a cerebral ischemic stroke or subarachnoid hematoma have been significantly developed over the years. Studies such as computer tomography or magnetic resonance imaging are extremely important for making a quick diagnosis. The development of technology and knowledge of the central nervous system has significantly reduced the number of deaths caused by cerebral disorders. The most important link in the procedure is a quick and accurate diagnosis of life threatening symptoms.

Stroke is the major cause of disability and the third leading cause of death among the adult population in Poland. Scientific studies have reported that approx. 60 000 Poles suffer a stroke each year. Approx. 80% of strokes are ischemic strokes. In 1980, the World Health Organization (WHO) has identified stroke as a clinical syndrome characterized by the sudden onset of focal or generalized brain dysfunction, the symptoms of which last longer than 24 hours or are leading to death and have no other cause than vascular one. In recent years, in order to restore patency in the clogged vessel supplying blood to the brain, the thrombolytic therapy with recombinant tissue plasminogen activator (rtPA) or streptokinase. This method, however, has a number of contraindications, therefore thrombectomy is an opportunity for those patients who are not eligible to apply thrombolysis. Thrombectomy is currently used only in patients with ischemic stroke in the 6 hour therapeutic window. It involves mechanical removal of the blockage using a catheter introduced into the cerebral vessels through the artery. The procedure is performed under angiographic control and takes about 40 minutes. This is a direct form of treatment of the disease, at its most advanced stage. Scientific reports say that nearly 90% of thrombectomy implementations is effective in case of acute stroke. Thanks to the progress of medicine, researchers aim at eliminating contraindications against qualifying a patient for thrombectomy treatment.