1. [Usefulness of 7 day therapy with cefluprenam in the management of respiratory tract infections]
- Author
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Kaoru SHIMADA, Mitsuhide OHMICHI, Hiroko SASAKI, Akira WATANABE, Kazuo SATO, Kosaku NAGAI, Kazuki KONISHI, Takashi OHTA, Yoshifumi MATSUURA, Hideki IKEDA, Kenichi IGARASHI, Fumihide IWATA, Koichi WADA, Michio MARUYAMA, Shigeyuki HOSHINO, Akira IWASHIMA, Yasutoshi SUZUKI, Osamu SEKINE, Nobuki AOKI, Saburo IZUMI, Toshio NAKAMURA, Toshiki IWABUCHI, Harumi SHISHIDO, Shoko TANOUE, Yuko KOMASE, Iwao SAKURAI, Kenji KASAI, Hiroyuki TERAWAKI, Michihiro TSUKUI, Keita HIRANO, Hiroyuki TANIGUCHI, Junya IKUTA, Akira YAMAGISAWA, Kunihiko GOTOH, Masashi YAMAMOTO, Mitsuo SATO, Akihisa KUMASAWA, Takashi SONODA, Jiro OKIMOTO, Makoto KIMURA, Hirohide YONEYAMA, Takayuki KARINO, Kazue FUJITA, Hideo OHBA, Takashi TSUYA, Akimasa OHUNE, Kohya SHIBA, Akira SAITOH, Hiroyuki KOBAYASHI, Toshiharu MATSUSHIMA, and Shigeru KOHNO
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,medicine.drug_class ,Cephalosporin ,Ceftazidime ,chemistry.chemical_compound ,Internal medicine ,Cefluprenam ,medicine ,Potency ,Humans ,Intensive care medicine ,Infusions, Intravenous ,Respiratory Tract Infections ,Aged ,Respiratory tract infections ,business.industry ,Incidence (epidemiology) ,Bacterial pneumonia ,General Medicine ,Middle Aged ,medicine.disease ,Rash ,Cephalosporins ,chemistry ,Female ,medicine.symptom ,business ,medicine.drug - Abstract
Efficacy and safety of a newer injectable cephalosporin, cefluprenam (CFLP) on cases with bacterial pneumonia and chronic respiratory tract infections were evaluated at a dose of 1g (potency), d.i.d for 7 days. 1. Of 130 cases in total, 116 cases were enrolled for the clinical efficacy evaluation. The efficacy rate (excellent and good responses) was 94.8% (110/116). The efficacy rate was 93.8% (60/64) for cases with bacterial pneumonia, and 96.2% (50/52) for cases with chronic respiratory tract infections. The recurrence was noted in 1.2% (1/82). The bacteriological response rate was 100.0% (32/32) for gram positive cocci, 93.8% (15/16) for gram negative rods and 97.9% (47/48) in total. 2. Adverse drug reactions were noted in 3.9% (5/129), consisting of 2 cases with skin rash, 1 case with drug fever, 1 case with skin rash and skin itching and 1 case with drug fever and headache. The abnormal laboratory changes were noted in 23.6% (30/127), mainly containing the elevation in GPT and GOT, and eosinophylia. The safety rate (no problem evaluation) was 74.8% (95/127). 3. The usefulness rate (very useful and useful evaluations) was 93.1% (108/116). As suggested by the evaluation on the secondary endpoint in the phase III comparative studies with both bacterial pneumonia and chronic respiratory tract infections, it was confirmed that the 7 day therapy of CFLP was promising for treatment of moderate bacterial pneumonia and chronic respiratory tract infections, because the high clinical efficacy was obtained and also the incidence of allergic reactions with CFLP was almost the same as that of ceftazidime (CAZ) evaluated highly safe. Based on these results, it was concluded that CFLP was useful in the management of moderate respiratory tract infections and also the recommended therapeutic period with CFLP was within 7 days.
- Published
- 1997