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578 results on '"Kosaka, Takashi"'

5. Is Prophylactic Splenectomy Necessary for Proximal Advanced Gastric Cancer Invading the Greater Curvature with Clinically Negative Splenic Hilar Lymph Node Metastasis? A Multi-Institutional Cohort Study (YCOG2003)

Author

Sato, Sho, Kunisaki, Chikara, Kondo, Hiroki, Tsuchiya, Nobuhiro, Tanaka, Yusaku, Takahashi, Masazumi, Sato, Kei, Kimura, Jun, Ono, Hidetaka A., Makino, Hirochika, Tamura, Yuko, Kasahara, Kohei, Kosaka, Takashi, Akiyama, Hirotoshi, and Endo, Itaru

Published
2022
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8. Numerical Analysis of Mechanical Characteristics of Joint Structure of Steel Pipe Sheet Pile Foundation

Author

Miyazaki, Yusuke, Sawamura, Yasuo, Kusaba, Shoma, Kimura, Makoto, Nishihara, Tomohiko, Kosaka, Takashi, Hattori, Masahiro, Maekawa, Kazuhiko, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Barla, Marco, editor, Di Donna, Alice, editor, and Sterpi, Donatella, editor

Published
2021
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10. High postoperative neutrophil–lymphocyte ratio and low preoperative lymphocyte-monocyte ratio predict poor prognosis in gastric cancer patients receiving gastrectomy with positive lavage cytology: a retrospective cohort study

Author

Sato, Sho, Kunisaki, Chikara, Takahashi, Masazumi, Kubo, Hirokazu, Tsuchiya, Nobuhiro, Sato, Kei, Miyamoto, Hiroshi, Tamura, Yuko, Kondo, Hiroki, Tanaka, Yusaku, Kasahara, Kohei, Kosaka, Takashi, Akiyama, Hirotoshi, Saigusa, Yusuke, and Endo, Itaru

Published
2021
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13. The real-world-data of immune-checkpoint inhibitor combination therapy for unresectable or metastatic esophageal cancer: A multi- institutional cohort study

Author

Sato, Sho, primary, Suzuki, Takashi, additional, Chinen, Yakashi, additional, Yamaguchi, Hironori, additional, Suzuki, Yusuke, additional, Hokamura, Nobukazu, additional, Saze, Zenichiro, additional, Kono, Koji, additional, Takahashi, Keita, additional, Yano, Fumiaki, additional, Kunisaki, Chikara, additional, Kosaka, Takashi, additional, Endo, Itaru, additional, Ichikawa, Yasushi, additional, Miyawaki, yutaka, additional, Sato, Hiroshi, additional, and Shimada, Hideaki, additional

Published
2024
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15. ASO Visual Abstract: Is Prophylactic Splenectomy Necessary for Proximal Advanced Gastric Cancer Invading the Greater Curvature with Clinically Negative Splenic Hilar Lymph Node Metastasis? A Multi-Institutional Cohort Study (YCOG2003)

Author

Sato, Sho, Kunisaki, Chikara, Kondo, Hiroki, Tsuchiya, Nobuhiro, Tanaka, Yusaku, Takahashi, Masazumi, Sato, Kei, Kimura, Jun, Ono, Hidetaka A., Makino, Hirochika, Tamura, Yuko, Kasahara, Kohei, Kosaka, Takashi, Akiyama, Hirotoshi, and Endo, Itaru

Published
2022
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18. Comparative Study on Insulation Lifetime of Stator Winding of Dual Inverter Fed Open Winding IPMSM and Single Inverter Fed Star-Connected IPMSM for EV Application

Author

Hayakawa, Teppei, Maeda, Yuto, Matsumori, Hiroaki, Kosaka, Takashi, Matsui, Nobuyuki, Miyoshi, Yoichi, Koga, Kiyotaka, and Saha, Subrata

Abstract

In this paper, the turn-to-turn insulation lifetime of a dual inverter fed open winding interior permanent magnet synchronous motor (OWIPMSM) is compared with a conventional single inverter fed star-connected interior permanent magnet synchronous motor (SCIPMSM) for an EV traction application via an on-line experiment. A twisted pair coil (TP) is connected between the line-to-line terminal of windings of an OWIPMSM and a SCIPMSM without rotor and the effect of the line-to-line terminal surge voltage on the turn-to-turn insulation lifetime using the TP is investigated by generating PWM pulses at the inverter output identical to a variable load traction inverter drive. The turn-to-turn insulation life of the TP windings is approximately estimated by measuring the capacitance of the TP windings at regular time intervals during the on-line testing. Finally, experiment is carried out to detect the partial discharge in the TP windings and understand the physical relationship that exists between the total partial discharge count number and the decrease in capacitance of the TP windings after a specified time-period of insulation life testing. From the present preliminary insulation lifetime testing results using the TP, it is found that for motors with the same ratings, an OWIPMSM could be designed with a lower insulation level winding than the SCIPMSM for an EV traction application.

Published
2024
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22. Attenuated Familial Adenomatous Polyposis

Author

Eizuka, Makoto, primary, Toya, Yosuke, additional, Kosaka, Takashi, additional, Oizumi, Tomofumi, additional, Morishita, Toshifumi, additional, Kasugai, Satoshi, additional, Yanai, Shunichi, additional, Sugai, Tamotsu, additional, and Matsumoto, Takayuki, additional

Published
2023
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26. Long-term Outcomes of Neoadjuvant Chemotherapy With Docetaxel, Cisplatin and S-1 for Stage III Gastric Cancer

Author

KASAHARA, KOHEI, primary, KUNISAKI, CHIKARA, additional, SATO, SHO, additional, KONDO, HIROKI, additional, TAKAHASHI, MASAZUMI, additional, TAMURA, YUKO, additional, TSUCHIYA, NOBUHIRO, additional, TANAKA, YUSAKU, additional, SATO, KEI, additional, KIMURA, JUN, additional, KOSAKA, TAKASHI, additional, ONO, HIDETAKA, additional, MAKINO, HIROCHIKA, additional, AKIYAMA, HIROTOSHI, additional, and ENDO, ITARU, additional

Published
2023
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32. Multicenter phase II study of capecitabine plus cisplatin as first-line therapy for human epidermal growth factor receptor 2-negative advanced gastric cancer: Yokohama Clinical Oncology Group Study YCOG1107

Author

Sato, Kei, Kunisaki, Chikara, Kosaka, Takashi, Takagawa, Ryo, Takahashi, Masazumi, Izumisawa, Yusuke, Miyamoto, Hiroshi, Sato, Sho, Tanaka, Yusaku, Yamaguchi, Naotaka, Kimura, Jun, Ono, Hidetaka A., Makino, Hirochika, Akiyama, Hirotoshi, and Endo, Itaru

Published
2017
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40. Higher intra-tumoral expression of pro-coagulation genes is a predictor of angiogenesis, epithelial mesenchymal transition and worse patient survival in gastric cancer

Author

Oshi, Masanori, Sarkar, Joy, Tokumaru, Yoshihisa, Yan, Li, Kosaka, Takashi, Akiyama, Hirotoshi, Nagahashi, Masayuki, Kunisaki, Chikara, Endo, Itaru, and Takabe, Kazuaki

Subjects
Original Article
Abstract

Coagulation regulates angiogenesis in cancer, and is associated with tumor development and metastasis. To date, there have been no studies quantifying the state of intra-tumoral coagulation. We measured intra-tumoral coagulation gene expression using the “Hallmark-COAGULATION” gene set in the MSigDB, performing gene set variation analysis and then assigning a “coagulation score” to quantify gene expression. Clinical, histologic, and genetic data were analyzed in 807 gastric cancer patients from the TCGA_STAD and GSE84437 databases. Tumors with increased expression of pro-coagulation genes were consistently associated with higher AJCC T-categories (p = 0.018), lymph node metastasis (p = 0.036), and stage (p = 0.006) in both cohorts. Patients with high coagulation scores were found to have worse disease-specific survival and overall survival (OS) (p = 0.019 and 0.011, respectively) in TCGA, and worse OS in GSE84437 cohort (p = 0.012). Higher expression of pro-coagulation genes correlated with increased intra-tumoral angiogenesis, as well as increased proportions of lymphatic and microvascular endothelial cells, endothelial cells, and pericytes, calculated by xCell algorithm. High coagulation scores were significantly associated with low tumor mutation burden, but not with intratumor heterogeneity and homologous recombination deficiency. Gastric cancers with high coagulation scores contained higher amounts of M1 macrophages and dendritic cells, and low numbers of Th1 cells (all P

Published
2022

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