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Your search keyword '"Kosaka, Kenshi"' showing total 13 results
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13 results on '"Kosaka, Kenshi"'

5. Bicytopenia in Primary Lung Melanoma Treated with Nivolumab

Author

Takahashi, Ayumu, primary, Kubo, Akihito, additional, Mizuno, Shohei, additional, Kasai, Kenji, additional, Asai, Nobuhiro, additional, Yonezawa, Toshiyuki, additional, Kosaka, Kenshi, additional, Nishimura, Masaki, additional, Tanaka, Hiroyuki, additional, Yokoe, Norihito, additional, Tsuzuki, Toyonori, additional, Takami, Akiyoshi, additional, and Yamaguchi, Etsuro, additional

Published
2019
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6. Prognostic impact of serum procalcitonin in non-small cell lung cancer

Author

Kajikawa, Shigehisa, Ohashi, Wataru, Kato, Yasutaka, Fukami, Masaya, Yonezawa, Toshiyuki, Sato, Mika, Kosaka, Kenshi, Kato, Toshio, Tanaka, Hiroyuki, Ito, Satoru, Yamaguchi, Etsuro, and Kubo, Akihito

Abstract

Introduction: Increased serum procalcitonin (PCT), a well-known biomarker for sepsis, has been reported in several cancer types. We aimed to investigate the prognostic impact of PCT in non-small cell lung cancer (NSCLC).Methods: Medical records of 51 consecutive patients with NSCLC (Aichi Medical University Hospital) admitted between July 2017 and July 2018 were retrospectively reviewed. The patients were divided into PCT-low (PCT < 0.1 ng/mL) and PCT-high (PCT ⩾ 0.1 ng/mL) groups, and their clinical characteristics and survival were compared.Results: In contrast to the PCT-low group (n = 24), the PCT-high group (n = 27) showed significantly worse Performance Status (PS) and overall survival (OS) (PS 0–2/3–4, 16/8 versus 12/15, p= 0.034; median OS, not reached versus 127 days, p< 0.001), irrespective of the presence of infection (p= 0.785). Multivariate analysis showed that the disease stage (IV versus I–III) and high PCT level (⩾0.1 versus <0.1 ng/mL) were significantly worse prognostic factors with hazard ratios of 3.706 (p= 0.023) and 3.951 (p= 0.010), respectively.Conclusion: The results suggest that serum PCT in NSCLC was elevated regardless of the presence of infection. Higher PCT levels are associated with poor PS and shorter OS in NSCLC.

Published
2021
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8. Clinical significance of serum anti-GM-CSF autoantibody levels in autoimmune pulmonary alveolar proteinosis

Author

Nishimura, Masaki, primary, Yamaguchi, Etsuro, additional, Takahashi, Ayumu, additional, Asai, Nobuhiro, additional, Katsuda, Eisuke, additional, Ohta, Toyohiro, additional, Ohtsuka, Yoshinori, additional, Kosaka, Kenshi, additional, Matsubara, Ayako, additional, Tanaka, Hiroyuki, additional, Yokoe, Norihito, additional, Kubo, Akihito, additional, Konno, Satoshi, additional, and Baba, Kenji, additional

Published
2018
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10. Interstitial Lung Disease after Pleurodesis for Malignant Pleural Effusion

Author

Yokoe, Norihito, primary, Katsuda, Eisuke, additional, Kosaka, Kenshi, additional, Hamanaka, Rie, additional, Matsubara, Ayako, additional, Nishimura, Masaki, additional, Tanaka, Hiroyuki, additional, Asai, Nobuhiro, additional, Takahashi, Ayumu, additional, Kawamura, Toshiki, additional, Ishiguchi, Tsuneo, additional, Yamaguchi, Etsuro, additional, and Kubo, Akihito, additional

Published
2017
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11. The ATS/ERS/JRS/ALAT Statement “IPF by HRCT” could Predict Acute Exacerbation of Interstitial Lung Disease in Non-small Cell Lung Cancer

Author

Asai, Nobuhiro, primary, Katsuda, Eisuke, additional, Hamanaka, Rie, additional, Kosaka, Kenshi, additional, Matsubara, Ayako, additional, Nishimura, Masaki, additional, Tanaka, Hiroyuki, additional, Yokoe, Norihito, additional, Takahashi, Ayumu, additional, Yamaguchi, Etsuro, additional, and Kubo, Akihito, additional

Published
2016
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12. Therapeutic and preventive antiemetic effect of aprepitant in Japanese patients with thoracic malignancies who truly need it

Author

Ito, Sumiyo, primary, Tsukiyama, Ikuto, additional, Ando, Masahiko, additional, Katakami, Masayo, additional, Hamanaka, Rie, additional, Kosaka, Kenshi, additional, Matsubara, Ayako, additional, Nishimura, Masaki, additional, Tanaka, Hiroyuki, additional, Asai, Nobuhiro, additional, Yokoe, Norihito, additional, Takahashi, Ayumu, additional, Baba, Kenji, additional, Matsuura, Katsuhiko, additional, Yamaguchi, Etsuro, additional, and Kubo, Akihito, additional

Published
2014
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13. [Four cases of bevacizumab-related gastrointestinal perforation].

Author

Uchino T, Mishima H, Kimura K, Mori D, Ando K, Nagata H, Kondo R, Kosaka K, Ohashi N, Ito N, Arikawa T, Miyachi M, Suzumura K, Sano T, and Nonami T

Subjects
Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Bevacizumab, Female, Humans, Intestinal Perforation chemically induced, Intestinal Perforation therapy, Male, Middle Aged, Antibodies, Monoclonal, Humanized adverse effects, Colorectal Neoplasms drug therapy, Intestinal Perforation surgery, Lung Neoplasms drug therapy
Abstract

We report 4 cases of gastrointestinal perforation associated with systemic administration of bevacizumab. Case 1: A 51- year-old man with colorectal cancer (CRC) received mFOLFOX+bevacizumab (Bev). A small intestinal perforation occurred 7 days after Bev administration (Bev-a) and was successfully treated with omental packing. Case 2: A 50-year-old woman with CRC received capecitabine+Bev. A small intestinal perforation was detected 5 days after Bev-a, and was successfully treated with primary suture and an omental flap. Case 3: A 74-year-old man with CRC received CapeOX+Bev. A duodenal perforation occurred on the same day as Bev-a, but could be treated conservatively. Case 4: A 57-year-old man with lung cancer received DTX+Bev. A small intestinal perforation occurred 13 days after Bev-a, but this could be managed with primary suture and an omental flap. The gastrointestinal perforation presented with mild abdominal pain and was detected within 14 days after Bev-a in each of these 4 cases. Three patients were successfully treated with only minimal surgical procedures and 1 patient could be managed with conservative treatment for a perforated duodenal ulcer.

Published
2014

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