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In a group of 228 patients suffering from asthma-prurigo syndrome the influence of emotional state, permanent residence and season time on dynamic of the clinical symptoms were studied. The evaluation of emotional state in 80 adult patients was carried-out by means of Eysenck Personality Inventory. The emotional state had less negative influence on the exacerbation of the symptoms upon children then in adults (especially on their skin symptoms). It was confirmed that the patients with high level of neurotic symptoms revealed easier the exacerbation of asthma and skin disorders under the influence of emotional stress. The climatic treatment on the sea-side was more efficient for them than any mountain climatic cure, especially in the treatment of airways symptoms. Similarly, the summer season brought the relief of their symptoms from both the respiratory and skin symptoms.

The group of 146 patients suffering from asthma-prurigo syndrome (85 adults and 64 children) have been inquired in many various clinical centers. It was established that in 79.6% of the patients the first symptoms of illness appeared already in infancy and only 28.2% of the patients had negative familiar anamnesis on the allergy. In 73.2% of the patients with asthma-prurigo syndrome the symptoms of atopic dermatitis persisted longer than asthma symptoms and in 89.9% of them asthma-prurigo symptoms accompanied other form of allergic diseases. The most important causal allergens provoking asthma-prurigo symptoms were: house dust (in 64.4% of the patients), chocolate (in 42.2%), cat epithelia (in 40.2%) and cow milk proteins (in 29.5% of the patients).

In a group of 228 patients with Asthma-Prurigo syndrome in 82.5% of patients the onset of skin lesions was earlier than the onset of asthma. It was found that the early onset of atopic dermatitis suggests the greater probability of subsequent asthma. In 88.6% of patients also other allergic diseases were diagnosed, and rhinitis allergica was observed most frequently. In the investigated group of patients urticaria chronica idiopathica or physical urticarias were not observed. Among 228 patients with Asthma-Prurigo syndrome, 74.6% of patients pointed to house dust as one of the most frequent causative factors. The house dust similarly to other inhalant allergens, somewhat more frequently had influence on the course of atopic dermatitis than on the course of asthma. Contrary to this observation according to patients food allergens (milk, eggs, fish, chocolate) aggravated or induced the relapses of skin lesions much more frequently than asthma. It was shown how often patients noticed adverse reactions due to penicillin and sulphonamides.

Oral hyposensitization was carried out in 26 patients with pollinosis and in 67 patients sensitive to house dust with all year symptoms of allergic disease of the skin, airways or conjunctivitis. The patients were hyposensitized with grass pollen extracts and house dust produced by Lab. Sevac. The pollen allergen was administered before the pollinating season, in increasing doses during 18 weeks. The following concentrations were used: 0.1 PNU, 1.0 PNU, 10 PNU, 100 PNU, and 1000 PNU. The house dust allergen was administered in the same manner, using the same concentrations and time during autumn and winter. In the group of patients with plant pollinosis 10 out of 26 did not experience any symptoms of the disease after hyposensitization. In 9 further patients the symptoms were milder. In the group of 44 patients with atopic dermatitis sensitive to house dust, a complete cure was seen in 62% of the patients. In further 25% milder symptoms were observed. In the group of 11 patients allergic to house dust and with the asthma-prurigo syndrome, the respiratory and dermatologic symptoms resolved completely or diminished in 3 and 6 patients respectively. In the group of 7 patients with dermatitis and full year rhinitis, complete resolvement of symptoms was seen in 2 patients and diminished symptoms in 3 cases. In the group of 4 patients with conjunctivitis full resolvement of symptoms was observed in 3, while partial in 1. Only in 3 out of 93 treated subjects intolerance of this therapy was found.(ABSTRACT TRUNCATED AT 250 WORDS)