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1. Electromagnetic Interference in Patients with Implanted Cardioverter-Defibrillators and Implantable Loop Recorders

Author

de Sousa, Marcos, Klein, Gunnar, Korte, Thomas, Niehaus, Michael, Singh, Balbir, Lokhandwala, Yash, Francis, Johnson, and Gupta, Anup

Subjects
JOURNALS: Indian Pacing and Electrophysiology Journal, Indian Pacing and Electrophysiology Journal
Abstract

Modern life exposes us all to an ever-increasing number of potential sources of electromagnetic interference (EMI) and patients with Implantable rhythm devices (IRD) like pacemakers, implantable cardioverter defibrillators or implantable loop recorders often ask about the use of microwave ovens, walking through airport metal detectors and the use of cellular phones. Electromagnetic interference occurs when electromagnetic waves emitted by one device impede the normal function of another electronic device. The potential for interaction between implanted pacing systems and cardioverter-defibrillators (electromagnetic interference, EMI) has been recognized for years.1,2,3,4. It has been shown that EMI can produce clinically significant effects on patients with implanted pacemakers and ICDs. For these reasons the following text discusses the influence of several EMI generating devices on IRD .

Published
2002

5. Supplementary Figure 1 from Loss of the Ceramide Transfer Protein Augments EGF Receptor Signaling in Breast Cancer

Author

Heering, Johanna, primary, Weis, Nicole, primary, Holeiter, Monika, primary, Neugart, Felix, primary, Staebler, Annette, primary, Fehm, Tanja N., primary, Bischoff, Annabell, primary, Schiller, Jürgen, primary, Duss, Stephan, primary, Schmid, Simone, primary, Korte, Thomas, primary, Herrmann, Andreas, primary, and Olayioye, Monilola A., primary

Published
2023
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6. Supplementary Figure 3 from Loss of the Ceramide Transfer Protein Augments EGF Receptor Signaling in Breast Cancer

Author

Heering, Johanna, primary, Weis, Nicole, primary, Holeiter, Monika, primary, Neugart, Felix, primary, Staebler, Annette, primary, Fehm, Tanja N., primary, Bischoff, Annabell, primary, Schiller, Jürgen, primary, Duss, Stephan, primary, Schmid, Simone, primary, Korte, Thomas, primary, Herrmann, Andreas, primary, and Olayioye, Monilola A., primary

Published
2023
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7. Supplementary Figure 4 from Loss of the Ceramide Transfer Protein Augments EGF Receptor Signaling in Breast Cancer

Author

Heering, Johanna, primary, Weis, Nicole, primary, Holeiter, Monika, primary, Neugart, Felix, primary, Staebler, Annette, primary, Fehm, Tanja N., primary, Bischoff, Annabell, primary, Schiller, Jürgen, primary, Duss, Stephan, primary, Schmid, Simone, primary, Korte, Thomas, primary, Herrmann, Andreas, primary, and Olayioye, Monilola A., primary

Published
2023
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8. Supplementary Figure 6 from Loss of the Ceramide Transfer Protein Augments EGF Receptor Signaling in Breast Cancer

Author

Heering, Johanna, primary, Weis, Nicole, primary, Holeiter, Monika, primary, Neugart, Felix, primary, Staebler, Annette, primary, Fehm, Tanja N., primary, Bischoff, Annabell, primary, Schiller, Jürgen, primary, Duss, Stephan, primary, Schmid, Simone, primary, Korte, Thomas, primary, Herrmann, Andreas, primary, and Olayioye, Monilola A., primary

Published
2023
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9. Supplementary Figure 5 from Loss of the Ceramide Transfer Protein Augments EGF Receptor Signaling in Breast Cancer

Author

Heering, Johanna, primary, Weis, Nicole, primary, Holeiter, Monika, primary, Neugart, Felix, primary, Staebler, Annette, primary, Fehm, Tanja N., primary, Bischoff, Annabell, primary, Schiller, Jürgen, primary, Duss, Stephan, primary, Schmid, Simone, primary, Korte, Thomas, primary, Herrmann, Andreas, primary, and Olayioye, Monilola A., primary

Published
2023
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10. Supplementary Figure Legends 1-6 from Loss of the Ceramide Transfer Protein Augments EGF Receptor Signaling in Breast Cancer

Author

Heering, Johanna, primary, Weis, Nicole, primary, Holeiter, Monika, primary, Neugart, Felix, primary, Staebler, Annette, primary, Fehm, Tanja N., primary, Bischoff, Annabell, primary, Schiller, Jürgen, primary, Duss, Stephan, primary, Schmid, Simone, primary, Korte, Thomas, primary, Herrmann, Andreas, primary, and Olayioye, Monilola A., primary

Published
2023
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11. Supplementary Methods from Loss of the Ceramide Transfer Protein Augments EGF Receptor Signaling in Breast Cancer

Author

Heering, Johanna, primary, Weis, Nicole, primary, Holeiter, Monika, primary, Neugart, Felix, primary, Staebler, Annette, primary, Fehm, Tanja N., primary, Bischoff, Annabell, primary, Schiller, Jürgen, primary, Duss, Stephan, primary, Schmid, Simone, primary, Korte, Thomas, primary, Herrmann, Andreas, primary, and Olayioye, Monilola A., primary

Published
2023
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12. Supplementary Figure 2 from Loss of the Ceramide Transfer Protein Augments EGF Receptor Signaling in Breast Cancer

Author

Heering, Johanna, primary, Weis, Nicole, primary, Holeiter, Monika, primary, Neugart, Felix, primary, Staebler, Annette, primary, Fehm, Tanja N., primary, Bischoff, Annabell, primary, Schiller, Jürgen, primary, Duss, Stephan, primary, Schmid, Simone, primary, Korte, Thomas, primary, Herrmann, Andreas, primary, and Olayioye, Monilola A., primary

Published
2023
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14. Cartilage Engineering

Author

Libera, Jeanette, Ruhnau, Klaus, Baum, Peter, Lüthi, Ursus, Schreyer, Thomas, Meyer, Ulrich, Wiesmann, Hans Peter, Herrmann, Andreas, Korte, Thomas, Pullig, Oliver, Siodla, Vilma, Meyer, Ulrich, editor, Handschel, Jörg, editor, Wiesmann, Hans Peter, editor, and Meyer, Thomas, editor

Published
2009
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17. Visualization of Marek’s Disease Virus Genomes in Living Cells during Lytic Replication and Latency

Author

Vychodil, Tereza, Wight, Darren, Nascimento, Mariana, Jolmes, Fabian, Korte, Thomas, Herrmann, Andreas, Kaufer, Benedikt B., Vychodil, Tereza, Wight, Darren, Nascimento, Mariana, Jolmes, Fabian, Korte, Thomas, Herrmann, Andreas, and Kaufer, Benedikt B.

Abstract

Visualization of the herpesvirus genomes during lytic replication and latency is mainly achieved by fluorescence in situ hybridization (FISH). Unfortunately, this technique cannot be used for the real-time detection of viral genome in living cells. To facilitate the visualization of the Marek’s disease virus (MDV) genome during all stages of the virus lifecycle, we took advantage of the well-established tetracycline operator/repressor (TetO/TetR) system. This system consists of a fluorescently labeled TetR (TetR-GFP) that specifically binds to an array of tetO sequences. This tetO repeat array was first inserted into the MDV genome (vTetO). Subsequently, we fused TetR-GFP via a P2a self-cleaving peptide to the C-terminus of the viral interleukin 8 (vIL8), which is expressed during lytic replication and latency. Upon reconstitution of this vTetO-TetR virus, fluorescently labeled replication compartments were detected in the nucleus during lytic replication. After validating the specificity of the observed signal, we used the system to visualize the genesis and mobility of the viral replication compartments. In addition, we assessed the infection of nuclei in syncytia as well as lytic replication and latency in T cells. Taken together, we established a system allowing us to track the MDV genome in living cells that can be applied to many other DNA viruses., Peer Reviewed

Published
2022

24. Yeast Sphingolipid-Enriched Domains and Membrane Compartments in the Absence of Mannosyldiinositolphosphorylceramide

Author

Oliveira, Andreia, Santos, Filipa, Trigo Marquês, Joaquim, Paulo, Pedro, Korte, Thomas, Herrmann, Andreas, Marinho, H. Susana, and De Almeida, Rodrigo

Subjects
sphingolipids, fluorescence lifetime imaging microscopy (FLIM), membrane compartments, 570 Biologie, Can1p, fluorescence spectroscopy, inositolphosphorylceramides, Saccharomyces cerevisiae, Pma1p, fungal plasma membrane, giant unilamellar vesicles (GUVs), ddc:570, lipids (amino acids, peptides, and proteins)
Abstract

The relevance of mannosyldiinositolphosphorylceramide [M(IP)2C] synthesis, the terminal complex sphingolipid class in the yeast Saccharomyces cerevisiae, for the lateral organization of the plasma membrane, and in particular for sphingolipid-enriched gel domains, was investigated by fluorescence spectroscopy and microscopy. We also addressed how changing the complex sphingolipid profile in the plasma membrane could influence the membrane compartments (MC) containing either the arginine/ H+ symporter Can1p (MCC) or the proton ATPase Pma1p (MCP). To achieve these goals, wild-type (wt) and ipt1Δ cells, which are unable to synthesize M(IP)2C accumulating mannosylinositolphosphorylceramide (MIPC), were compared. Living cells, isolated plasma membrane and giant unilamellar vesicles reconstituted from plasma membrane lipids were labelled with various fluorescent membrane probes that report the presence and organization of distinct lipid domains, global order, and dielectric properties. Can1p and Pma1p were tagged with GFP and mRFP, respectively, in both yeast strains, to evaluate their lateral organization using confocal fluorescence intensity and fluorescence lifetime imaging. The results show that IPT1 deletion strongly affects the rigidity of gel domains but not their relative abundance, whereas no significant alterations could be perceived in ergosterol-enriched domains. Moreover, in these cells lacking M(IP)2C, a clear alteration in Pma1p membrane distribution, but no significant changes in Can1p distribution, were observed. Thus, this work reinforces the notion that sphingolipid-enriched domains distinct from ergosterol-enriched regions are present in the S. cerevisiae plasma membrane and suggests that M(IP)2C is important for a proper hydrophobic chain packing of sphingolipids in the gel domains of wt cells. Furthermore, our results strongly support the involvement of sphingolipid domains in the formation and stability of the MCP, possibly being enriched in this compartment.

Published
2020

50. Differential effects of PER2 phosphorylation: Molecular basis for the human familial advanced sleep phase syndrome (FASPS)

Author

Vanselow, Katja, Vanselow, Jens T., Westermark, Pal O., Reischl, Silke, Maier, Bert, Korte, Thomas, Herrmann, Andreas, Herzel, Hanspeter, Schlosser, Andreas, and Kramer, Achim

Subjects
Circadian rhythms -- Research, Drosophila -- Physiological aspects, Drosophila -- Research, Phosphorylation -- Analysis, Biological sciences
Abstract

Mathematical modeling is used to predict that differential PERIOD (PER) phosphorylation events can result in opposite period phenotypes. The interference with specific aspects of mPER2 phosphorylation leads to either short or long periods in oscillating fibroblasts and this concept describes not only the familial advanced sleep phase syndrome phenotype, but also the effect of the tau mutation in hamster as well as the doubletime mutants in Drosophila.

Published
2006

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