29 results on '"Korsbæk, Johanne Juhl"'
Search Results
2. Metabolic Dysfunction in New‐Onset Idiopathic Intracranial Hypertension: Identification of Novel Biomarkers.
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Korsbæk, Johanne Juhl, Jensen, Rigmor Højland, Beier, Dagmar, Wibroe, Elisabeth Arnberg, Hagen, Snorre Malm, Molander, Laleh Dehghani, Gillum, Matthew Paul, Svart, Katrine, Hansen, Thomas Folkmann, Kogelman, Lisette J.A., and Westgate, Connar Stanley James
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OPTIC nerve , *BODY mass index , *METABOLIC disorders , *NERVE fibers , *CEREBROSPINAL fluid - Abstract
Objective: Idiopathic intracranial hypertension (IIH) is a neurometabolic disease with an increasing incidence. The pathophysiology is unknown, but improvement of diagnosis and management requires discovery of novel biomarkers. Our objective was to identify such candidate biomarkers in IIH, and secondarily, test for associations between identified metabolites and disease severity. Methods: This is a prospective case–control study with collection of cerebrospinal fluid (CSF), serum, and clinical data from new‐onset, treatment‐naïve patients with IIH (n = 60). Patients were included consecutively from 2 tertiary headache centers in Denmark, and age, sex, and body mass index (BMI) ‐matched healthy controls (n = 35) were recruited. Clinical data were retrieved at ocular remission (n = 55). Samples were analyzed using non‐targeted mass spectrometry. Results: Serum sphingosine 1‐phosphate (S1P), adenosine, and glutamate were 0.46‐fold (q < 0.0001), 0.25‐fold (q = 0.0048), and 0.44‐fold (q < 0.0001) lower, respectively, in IIH. CSF stearoyl‐lysophosphatidylcholine (LysoPC‐18) and 2‐palmitoyl‐lysophosphatidylcholine (LysoPC‐16) were 0.42 (q = 0.0025) and 0.37 (q < 0.001) ‐fold lower. LysoPC‐18 was higher in patients with moderate–severe versus mild papilledema (p = 0.022). LysoPC‐18 correlated positively with retinal nerve fiber layer thickness (p = 0.0012, r = 0.42) and inversely with mean deviation on automated perimetry (p = 0.01, r = −0.35). Higher baseline serum S1P (p = 0.018) and lower CSF LysoPC‐16 (p = 0.003) were associated with optic nerve atrophy at ocular remission. Pathway analysis suggests dysregulated lipid metabolism and redox disturbances in new‐onset IIH. Interpretation: We identify perturbed metabolism in new‐onset IIH. S1P and LysoPC‐16 demonstrate potential prognostic value due to association with subsequent optic nerve atrophy. This association between specific, differential metabolites and outcome provides substantial evidence for novel biomarkers of clinical significance that should be the focus of further targeted studies. ANN NEUROL 2024;96:595–607 [ABSTRACT FROM AUTHOR]
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- 2024
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3. Are the ICHD-3 criteria for headache attributed to idiopathic intracranial hypertension valid? Headache phenotyping and field-testing in newly diagnosed idiopathic intracranial hypertension
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Hansen, Nadja Skadkær, Korsbæk, Johanne Juhl, Yri, Hanne Maria, Jensen, Rigmor Højland, Beier, Dagmar, Hansen, Nadja Skadkær, Korsbæk, Johanne Juhl, Yri, Hanne Maria, Jensen, Rigmor Højland, and Beier, Dagmar
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Background Headache burden is substantial in idiopathic intracranial hypertension. The classification of idiopathic intracranial hypertension headache by the International Classification of Headache Disorders (ICHD) is an important tool for research and clinical purposes. Methods We phenotyped headaches and tested sensitivity and specificity of the ICHD-3 criteria for idiopathic intracranial hypertension headache in a prospective cohort of patients suspected of idiopathic intracranial hypertension at two tertiary headache centers. Results Sensitivity was 93% and specificity was 100% of ICHD-3 criteria for idiopathic intracranial hypertension-related headache validated in idiopathic intracranial hypertension (n = 140) and patients in whom idiopathic intracranial hypertension was suspected but disproven (n = 103). The phenotype of new/worsened headaches related to idiopathic intracranial hypertension suspicion was equally migraine-like (p = 0.76) and tension-type-like (p = 0.08). Lumbar puncture opening pressure was higher (p < 0.0001) and pulsatile tinnitus more frequent (p < 0.0001) in idiopathic intracranial hypertension patients, but neither improved the applicability of the headache criteria, nor did papilledema. Conclusion Headache phenotype is not distinct in idiopathic intracranial hypertension. ICHD-3 criteria for idiopathic intracranial hypertension headache are sensitive and specific, but simplicity can be improved without compromising accuracy. We propose that a new or worsened headache temporally related to active idiopathic intracranial hypertension is a sufficient criterion for idiopathic intracranial hypertension headache regardless of headache phenotype or accompanying symptoms, and that elements of idiopathic intracranial hypertension diagnostics (papilledema and opening pressure) be segregated from headache criteria., Background: Headache burden is substantial in idiopathic intracranial hypertension. The classification of idiopathic intracranial hypertension headache by the International Classification of Headache Disorders (ICHD) is an important tool for research and clinical purposes. Methods: We phenotyped headaches and tested sensitivity and specificity of the ICHD-3 criteria for idiopathic intracranial hypertension headache in a prospective cohort of patients suspected of idiopathic intracranial hypertension at two tertiary headache centers. Results: Sensitivity was 93% and specificity was 100% of ICHD-3 criteria for idiopathic intracranial hypertension-related headache validated in idiopathic intracranial hypertension (n = 140) and patients in whom idiopathic intracranial hypertension was suspected but disproven (n = 103). The phenotype of new/worsened headaches related to idiopathic intracranial hypertension suspicion was equally migraine-like (p = 0.76) and tension-type-like (p = 0.08). Lumbar puncture opening pressure was higher (p < 0.0001) and pulsatile tinnitus more frequent (p < 0.0001) in idiopathic intracranial hypertension patients, but neither improved the applicability of the headache criteria, nor did papilledema. Conclusion: Headache phenotype is not distinct in idiopathic intracranial hypertension. ICHD-3 criteria for idiopathic intracranial hypertension headache are sensitive and specific, but simplicity can be improved without compromising accuracy. We propose that a new or worsened headache temporally related to active idiopathic intracranial hypertension is a sufficient criterion for idiopathic intracranial hypertension headache regardless of headache phenotype or accompanying symptoms, and that elements of idiopathic intracranial hypertension diagnostics (papilledema and opening pressure) be segregated from headache criteria. Trial Registration: ClinicalTrials.gov Identifier: NCT04032379
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- 2024
4. Fundus imaging and perimetry in patients with idiopathic intracranial hypertension—an intermethod and interrater validity study
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Rissan, Zainab, primary, Hansen, Nadja Skadkær, additional, Carlsen, Louise Ninett, additional, Korsbæk, Johanne Juhl, additional, Jensen, Rigmor Højland, additional, Hamann, Steffen, additional, and Schytz, Henrik Winther, additional
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- 2023
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5. Diagnosis of idiopathic intracranial hypertension: A proposal for evidence-based diagnostic criteria
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Korsbæk, Johanne Juhl, primary, Jensen, Rigmor Højland, additional, Høgedal, Lisbeth, additional, Molander, Laleh Dehghani, additional, Hagen, Snorre Malm, additional, and Beier, Dagmar, additional
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- 2023
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6. Retinal vessel dynamics analysis as a surrogate marker for raised intracranial pressure in patients with suspected idiopathic intracranial hypertension
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Hagen, Snorre Malm, primary, Wibroe, Elisabeth Arnberg, additional, Korsbæk, Johanne Juhl, additional, Andersen, Mikkel Schou, additional, Nielsen, Asger Bjørnær, additional, Nortvig, Mathias Just, additional, Beier, Dagmar, additional, Poulsen, Frantz Rom, additional, Jensen, Rigmor Højland, additional, and Hamann, Steffen, additional
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- 2023
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7. Fundus imaging and perimetry in patients with idiopathic intracranial hypertension—an intermethod and interrater validity study
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Rissan, Zainab, Hansen, Nadja Skadkær, Carlsen, Louise Ninett, Korsbæk, Johanne Juhl, Jensen, Rigmor Højland, Hamann, Steffen, Schytz, Henrik Winther, Rissan, Zainab, Hansen, Nadja Skadkær, Carlsen, Louise Ninett, Korsbæk, Johanne Juhl, Jensen, Rigmor Højland, Hamann, Steffen, and Schytz, Henrik Winther
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Background and purpose There is a need to improve the diagnostic process of patients suspected of papilledema. In patients with known or suspected idiopathic intracranial hypertension a fundus imaging and perimetric visual field assessment system (COMPASS) performed at a headache center was validated in comparison to an assessment (Topcon plus OCTOPUS) at a neuroophthalmological clinic. Methods For intermethod assessment, blinded fundus images and perimetry from COMPASS versus Topcon plus OCTOPUS were assessed by a neuroophthalmologist. For interrater assessment, fundus images and perimetry obtained by the COMPASS system were assessed by an untrained medical doctor, a trained neurologist and a trained medical student and compared to the neuroophthalmologist's assessments. Results For the intermethod variation of the presence of papilledema on fundus images, a kappa value of 0.60, sensitivity of 87% and specificity of 73% were found. The interrater variation of the presence of papilledema on fundus images showed kappa values ranging from 0.43 to 0.74, sensitivity values ranging from 70% to 96% and specificity values ranging from 46% to 93% when comparing the assessments made by the headache center staff with neuroophthalmologist's assessments. The COMPASS showed a 59% sensitivity and moderate agreement in detecting visual field defects compared with OCTOPUS. The visual field assessment showed only slight to fair agreement from 0.19 to 0.31 between assessments made by the headache center staff and the neuroophthalmologist. Conclusion The COMPASS system can be used with reasonable sensitivity in the assessment of papilledema in patients suspected of idiopathic intracranial hypertension at a tertiary headache center., Background and purpose: There is a need to improve the diagnostic process of patients suspected of papilledema. In patients with known or suspected idiopathic intracranial hypertension a fundus imaging and perimetric visual field assessment system (COMPASS) performed at a headache center was validated in comparison to an assessment (Topcon plus OCTOPUS) at a neuroophthalmological clinic. Methods: For intermethod assessment, blinded fundus images and perimetry from COMPASS versus Topcon plus OCTOPUS were assessed by a neuroophthalmologist. For interrater assessment, fundus images and perimetry obtained by the COMPASS system were assessed by an untrained medical doctor, a trained neurologist and a trained medical student and compared to the neuroophthalmologist's assessments. Results: For the intermethod variation of the presence of papilledema on fundus images, a kappa value of 0.60, sensitivity of 87% and specificity of 73% were found. The interrater variation of the presence of papilledema on fundus images showed kappa values ranging from 0.43 to 0.74, sensitivity values ranging from 70% to 96% and specificity values ranging from 46% to 93% when comparing the assessments made by the headache center staff with neuroophthalmologist's assessments. The COMPASS showed a 59% sensitivity and moderate agreement in detecting visual field defects compared with OCTOPUS. The visual field assessment showed only slight to fair agreement from 0.19 to 0.31 between assessments made by the headache center staff and the neuroophthalmologist. Conclusion: The COMPASS system can be used with reasonable sensitivity in the assessment of papilledema in patients suspected of idiopathic intracranial hypertension at a tertiary headache center.
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- 2023
8. Diagnosis of idiopathic intracranial hypertension:A proposal for evidence-based diagnostic criteria
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Korsbæk, Johanne Juhl, Jensen, Rigmor Højland, Høgedal, Lisbeth, Molander, Laleh Dehghani, Hagen, Snorre Malm, Beier, Dagmar, Korsbæk, Johanne Juhl, Jensen, Rigmor Højland, Høgedal, Lisbeth, Molander, Laleh Dehghani, Hagen, Snorre Malm, and Beier, Dagmar
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BACKGROUND: Based on expert opinion, abducens nerve palsy and a neuroimaging criterion (≥3 neuroimaging signs suggestive of elevated intracranial pressure) were added to the diagnostic criteria for idiopathic intracranial hypertension. Our objective was to validate this. METHODS: This prospective study included patients with new-onset idiopathic intracranial hypertension for a standardized work-up: interview, neuro-ophthalmological exam, lumbar puncture, neuroimaging. Neuroimaging was evaluated by a blinded neuroradiologist. RESULTS: We included 157 patients classified as idiopathic intracranial hypertension (56.7%), probable idiopathic intracranial hypertension (1.9%), idiopathic intracranial hypertension without papilledema (idiopathic intracranial hypertension-without papill edema; 0%), suggested idiopathic intracranial hypertension-without papill edema (4.5%), or non-idiopathic intracranial hypertension (36.9%). Moderate suprasellar herniation was more common in idiopathic intracranial hypertension than non-idiopathic intracranial hypertension (71.4% versus 47.4%, p < 0.01), as was perioptic nerve sheath distension (69.8% versus 29.3%, p < 0.001), flattening of the globe (67.1% versus 11.1%, p < 0.001) and transverse sinus stenosis (60.2% versus 18.9%, p < 0.001). Abducens nerve palsy was of no diagnostic significance. Sensitivity of ≥3 neuroimaging signs was 59.5% and specificity was 93.5%. CONCLUSION: Moderate suprasellar herniation, distension of the perioptic nerve sheath, flattening of the globe and transverse sinus stenosis were associated with idiopathic intracranial hypertension. We propose that idiopathic intracranial hypertension can be defined by two out of three objective findings (papilledema, opening pressure ≥25 cm cerebrospinal fluid and ≥3 neuroimaging signs).
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- 2023
9. Phenotyping non-idiopathic pseudotumor cerebri syndrome – A prospective cohort study
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Svart, Katrine, primary, Jensen, Rigmor Højland, additional, Høgedal, Lisbeth, additional, Vukovic-Cvetkovic, Vlasta, additional, Beier, Dagmar, additional, and Korsbæk, Johanne Juhl, additional
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- 2022
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10. Psychiatric Comorbidities in Patients With Idiopathic Intracranial Hypertension
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Korsbæk, Johanne Juhl, primary, Beier, Dagmar, additional, Hagen, Snorre Malm, additional, Molander, Laleh Dehghani, additional, and Jensen, Rigmor Højland, additional
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- 2022
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11. Psychiatric Comorbidities in Patients with Idiopathic Intracranial Hypertension:A Prospective Cohort Study
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Korsbæk, Johanne Juhl, Beier, Dagmar, Hagen, Snorre Malm, Molander, Laleh Dehghani, Jensen, Rigmor Højland, Korsbæk, Johanne Juhl, Beier, Dagmar, Hagen, Snorre Malm, Molander, Laleh Dehghani, and Jensen, Rigmor Højland
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Background and Objectives Psychiatric disease is a frequent comorbidity in idiopathic intracranial hypertension (IIH) and has been associated with a poor subjective outcome. No prospective studies have investigated psychiatric comorbidities in new-onset IIH. Our primary aim was to investigate disease severity in IIH depending on comorbid psychiatric disease. Important secondary outcomes were disease severity after 6 months and prevalence of psychiatric diseases in IIH. Methods This prospective, observational cohort study consecutively included patients with clinically suspected, new-onset IIH from 2 headache centers. A standardized diagnostic workup was completed to confirm or exclude IIH according to the revised Friedman criteria: semi-structured interview, neurologic and neuro-ophthalmologic examination, lumbar puncture with opening pressure (OP), and neuroimaging. Exclusion criteria were known IIH, secondary intracranial hypertension, missing data, and pregnancy. Disease severity was evaluated based on papilledema, visual fields, OP, and headache in patients with IIH without psychiatric disease (IIH−P) compared with patients with IIH with psychiatric disease (IIH+P). A blinded neuro-ophthalmologist assessed visual outcomes. Age- and sex-matched prevalence rates of psychiatric diseases in the general population were found in national reports. Results A total of 258 patients were screened; 69 were excluded. A total of 189 patients with clinically suspected IIH were then evaluated with the diagnostic workup and IIH was confirmed in 111 patients (58.7%). A total of 45% of patients with IIH had a psychiatric comorbidity. Visual fields were worse in patients with IIH+P at baseline (−8.0 vs −6.0 dB; p = 0.04) and after 6 months (−5.5 vs −4.0 dB; p < 0.01) compared with IIH−P. Highly prevalent psychiatric disorders were major depressive disorder (24.3%; n = 27), anxiety or stress-related disorders (24.3%; n = 27), and emotionally unstable personality, Background and ObjectivesPsychiatric disease is a frequent comorbidity in idiopathic intracranial hypertension (IIH) and has been associated with a poor subjective outcome. No prospective studies have investigated psychiatric comorbidities in new-onset IIH. Our primary aim was to investigate disease severity in IIH depending on comorbid psychiatric disease. Important secondary outcomes were disease severity after 6 months and prevalence of psychiatric diseases in IIH.MethodsThis prospective, observational cohort study consecutively included patients with clinically suspected, new-onset IIH from 2 headache centers. A standardized diagnostic workup was completed to confirm or exclude IIH according to the revised Friedman criteria: semi-structured interview, neurologic and neuro-ophthalmologic examination, lumbar puncture with opening pressure (OP), and neuroimaging. Exclusion criteria were known IIH, secondary intracranial hypertension, missing data, and pregnancy. Disease severity was evaluated based on papilledema, visual fields, OP, and headache in patients with IIH without psychiatric disease (IIH-P) compared with patients with IIH with psychiatric disease (IIH+P). A blinded neuro-ophthalmologist assessed visual outcomes. Age- and sex-matched prevalence rates of psychiatric diseases in the general population were found in national reports.ResultsA total of 258 patients were screened; 69 were excluded. A total of 189 patients with clinically suspected IIH were then evaluated with the diagnostic workup and IIH was confirmed in 111 patients (58.7%). A total of 45% of patients with IIH had a psychiatric comorbidity. Visual fields were worse in patients with IIH+P at baseline (-8.0 vs -6.0 dB; p = 0.04) and after 6 months (-5.5 vs -4.0 dB; p < 0.01) compared with IIH-P. Highly prevalent psychiatric disorders were major depressive disorder (24.3%; n = 27), anxiety or stress-related disorders (24.3%; n = 27), and emotionally unstable personality disorder (6.3%; n =
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- 2022
12. Phenotyping non-idiopathic pseudotumor cerebri syndrome – A prospective cohort study
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Svart, Katrine, Jensen, Rigmor Højland, Høgedal, Lisbeth, Vukovic-Cvetkovic, Vlasta, Beier, Dagmar, Korsbæk, Johanne Juhl, Svart, Katrine, Jensen, Rigmor Højland, Høgedal, Lisbeth, Vukovic-Cvetkovic, Vlasta, Beier, Dagmar, and Korsbæk, Johanne Juhl
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Objective: To identify the most frequent causes of secondary pseudotumor cerebri syndrome and compare phenotype, clinical presentation, and symptoms of secondary pseudotumor cerebri syndrome to the primary form of pseudotumor cerebri syndrome, idiopathic intracranial hypertension. Methods: The study was a prospective cohort study including patients with new-onset pseudotumor cerebri syndrome. Diagnostic work up was standardized. Patients were diagnosed with secondary pseudotumor cerebri syndrome or idiopathic intracranial hypertension according to the revised Friedman criteria. Secondary pseudotumor cerebri syndrome patients were categorized into five causes: medication, systemic causes, sleep apnea, cerebrovascular causes, and several competing causes. Phenotype, clinical presentation, symptoms and neuroimaging were compared between groups. Results: Out of 278 cases, 28 secondary pseudotumor cerebri syndrome and 120 idiopathic intracranial hypertension patients were included. The most frequent causes of secondary pseudotumor cerebri syndrome were medication (n = 8, 28.6%) and systemic causes (n = 8, 28.6%), followed by sleep apnea (n = 5, 17.9%), cerebrovascular causes (n = 4, 14.3%) and several competing causes (n = 3, 10.7%). Secondary pseudotumor cerebri syndrome and idiopathic intracranial hypertension patients were phenotypically alike and predominately female, premenopausal, and obese. Symptoms and objective findings at disease onset were similar between groups. Conclusion: Secondary pseudotumor cerebri syndrome should be considered in all patients with suspected pseudotumor cerebri syndrome as secondary pseudotumor cerebri syndrome and idiopathic intracranial hypertension patients are phenotypically and clinically alike. A thorough diagnostic workup is needed as treatment of idiopathic intracranial hypertension and secondary pseudotumor cerebri syndrome is markedly different.
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- 2022
13. Diagnosis of idiopathic intracranial hypertension - the importance of excluding secondary causes:A systematic review
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Kilic, Kubra, Korsbæk, Johanne Juhl, Jensen, Rigmor H., Cvetkovic, Vlasta Vukovic, Kilic, Kubra, Korsbæk, Johanne Juhl, Jensen, Rigmor H., and Cvetkovic, Vlasta Vukovic
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Background: Idiopathic intracranial hypertension is characterized by increased intracranial pressure without any pathological findings on neuroimaging, except for signs of high intracranial pressure. Before diagnosing idiopathic intracranial hypertension secondary causes of increased intracranial pressure should be excluded. Objective: to characterize the phenotype of patients with secondary intracranial hypertension and to identify possible risk factors for secondary intracranial hypertension. Methods: We have systematically searched the PubMed database. The publications were analyzed according to the patient phenotype, age, gender, comorbidities, body mass index/weight status, and additional medication. The results are summarized in four categories: medication, infection, hormonal induced intracranial hypertension and miscellaneous groups of diseases related to sIH. Results: We identified 105 eligible papers which included 272 cases. There were 49.6% pediatric cases. Among the adult group,70.9% were women. A total of 40.4% of all cases were obese or overweight, 27% among adults and 13.4% among pediatric cases. Increased BMI and recent weight gain, anemia, renal diseases and hypertension were the most frequent comorbidities related to sIH. Conclusion: Among sIH patients, 40.4% were obese or overweight; two thirds were women. We recommend that even patients with a typical IIH phenotype should be screened for secondary causes.
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- 2022
14. Transorbital sonography:A non-invasive bedside screening tool for detection of pseudotumor cerebri syndrome
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Korsbæk, Johanne Juhl, Hagen, Snorre Malm, Schytz, Henrik W., Vukovic-Cvetkovic, Vlasta, Wibroe, Elisabeth Arnberg, Hamann, Steffen, Jensen, Rigmor H., Korsbæk, Johanne Juhl, Hagen, Snorre Malm, Schytz, Henrik W., Vukovic-Cvetkovic, Vlasta, Wibroe, Elisabeth Arnberg, Hamann, Steffen, and Jensen, Rigmor H.
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Background: Our objective was to assess optic nerve sheath diameter (a marker of elevated intracranial pressure) and optic disc elevation (a marker of papilledema) in pseudotumor cerebri syndrome using transorbital sonography. Methods: The study was a prospective case-control study. We included patients with new-onset pseudotumor cerebri syndrome and matched healthy controls. All had fundoscopy, lumbar puncture with opening pressure and transorbital sonography. Sonography was assessed by a blinded observer. Results: We evaluated 45 patients and included 23 cases. We recruited 35 controls. Optic nerve sheath diameter was larger in pseudotumor cerebri syndrome compared to controls (6.3 ± 0.9 mm versus 5.0 ± 0.5 mm, p < 0.001) and so was optic disc elevation (0.9 ± 0.4 mm versus 0.4 ± 0.1 mm, p < 0.001). The optimal cut-off point for optic nerve sheath diameter was 6 mm with a sensitivity of 74% for prediction of pseudotumor cerebri syndrome and 68% for prediction of elevated opening pressure. Specificity was 94%. The optimal cut-off point for optic disc elevation was 0.6 mm. Sensitivity was 100% and specificity 83% for prediction of pseudotumor cerebri syndrome. Conclusion: Optic disc elevation and optic nerve sheath diameter are increased in new-onset pseudotumor cerebri syndrome. Optic disc elevation achieved high specificity and excellent sensitivity for diagnosis of pseudotumor cerebri syndrome. Transorbital sonography (TOS) is a potential, non-invasive screening tool for pseudotumor cerebri syndrome in headache clinics.
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- 2022
15. Transorbital sonography: A non-invasive bedside screening tool for detection of pseudotumor cerebri syndrome
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Korsbæk, Johanne Juhl, primary, Hagen, Snorre Malm, additional, Schytz, Henrik W, additional, Vukovic-Cvetkovic, Vlasta, additional, Wibroe, Elisabeth Arnberg, additional, Hamann, Steffen, additional, and Jensen, Rigmor H, additional
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- 2022
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16. sj-pdf-2-cep-10.1177_03331024221094293 - Supplemental material for Transorbital sonography: A non-invasive bedside screening tool for detection of pseudotumor cerebri syndrome
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Korsbæk, Johanne Juhl, Hagen, Snorre Malm, Schytz, Henrik W, Vukovic-Cvetkovic, Vlasta, Wibroe, Elisabeth Arnberg, Hamann, Steffen, and Jensen, Rigmor H
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FOS: Psychology ,FOS: Clinical medicine ,170199 Psychology not elsewhere classified ,110319 Psychiatry (incl. Psychotherapy) ,110306 Endocrinology ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified ,110904 Neurology and Neuromuscular Diseases ,Neuroscience - Abstract
Supplemental material, sj-pdf-2-cep-10.1177_03331024221094293 for Transorbital sonography: A non-invasive bedside screening tool for detection of pseudotumor cerebri syndrome by Johanne Juhl Korsbæk, Snorre Malm Hagen, Henrik W Schytz, Vlasta Vukovic-Cvetkovic, Elisabeth Arnberg Wibroe, Steffen Hamann and Rigmor H Jensen in Cephalalgia
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- 2022
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17. sj-pdf-1-cep-10.1177_03331024221094293 - Supplemental material for Transorbital sonography: A non-invasive bedside screening tool for detection of pseudotumor cerebri syndrome
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Korsbæk, Johanne Juhl, Hagen, Snorre Malm, Schytz, Henrik W, Vukovic-Cvetkovic, Vlasta, Wibroe, Elisabeth Arnberg, Hamann, Steffen, and Jensen, Rigmor H
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FOS: Psychology ,FOS: Clinical medicine ,170199 Psychology not elsewhere classified ,110319 Psychiatry (incl. Psychotherapy) ,110306 Endocrinology ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified ,110904 Neurology and Neuromuscular Diseases ,Neuroscience - Abstract
Supplemental material, sj-pdf-1-cep-10.1177_03331024221094293 for Transorbital sonography: A non-invasive bedside screening tool for detection of pseudotumor cerebri syndrome by Johanne Juhl Korsbæk, Snorre Malm Hagen, Henrik W Schytz, Vlasta Vukovic-Cvetkovic, Elisabeth Arnberg Wibroe, Steffen Hamann and Rigmor H Jensen in Cephalalgia
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- 2022
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18. Diagnosis of idiopathic intracranial hypertension - the importance of excluding secondary causes: A systematic review
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Kilic, Kubra, primary, Korsbæk, Johanne Juhl, additional, Jensen, Rigmor H, additional, and Cvetkovic, Vlasta Vukovic, additional
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- 2021
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19. Idiopatisk intrakraniel hypertension
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Korsbæk, Johanne Juhl, Beier, Dagmar, Wegener, Marianne, Hamann, Steffen, Cvetkovic, Vlasta Vukovic, Jensen, Rigmor Højland, Korsbæk, Johanne Juhl, Beier, Dagmar, Wegener, Marianne, Hamann, Steffen, Cvetkovic, Vlasta Vukovic, and Jensen, Rigmor Højland
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Idiopathic intracranial hypertension (IIH) is a challenging disease characterized by an increase in intracranial pressure which occurs without any known cause. The disease is mainly seen in obese females of child-bearing age. While originally described as rare, the incidence is increasing in parallel with pandemic obesity, and clinicians in all fields are increasingly likely to meet patients with IIH. The condition causes major morbidity due to chronic headache and visual loss if untreated. In the past ten years new diagnostic criteria and guidelines for management have been published.
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- 2021
20. Awareness, diagnosis and management of idiopathic intracranial hypertension
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Jensen, Rigmor Højland, Vukovic-Cvetkovic, Vlasta, Korsbaek, Johanne Juhl, Wegener, Marianne, Hamann, Steffen Ellitsgaard, Beier, Dagmar, Jensen, Rigmor Højland, Vukovic-Cvetkovic, Vlasta, Korsbaek, Johanne Juhl, Wegener, Marianne, Hamann, Steffen Ellitsgaard, and Beier, Dagmar
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The diagnosis and management of idiopathic intracranial hypertension (IIH) can be difficult and multiple medical subspecialities are often involved. Several national and international guidelines regarding the investigations and management of IIH have been published in recent years but still there is no consensus about the optimal organization of IIH-care. The objective of this review was to propose and describe a referral pathway and an organization scheme for diagnosis and management of IIH. An extensive search of existing literature was conducted and summarized. In total, 237 IIH-articles were identified and hereof 43 included. The clinical practice in our specialized IIH-clinic is characterized and described. We conclude that an educational campaign involving medical care providers and patients with chronic headaches is necessary. A detailed organizational proposal for a referral pathway and management of IIH patients based on the literature search and our clinical experience from a highly specialized IIH outpatient clinic is suggested and discussed.
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- 2021
21. Diagnosis of idiopathic intracranial hypertension - the importance of excluding secondary causes: A systematic review.
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Kilic, Kubra, Korsbæk, Johanne Juhl, Jensen, Rigmor H, and Cvetkovic, Vlasta Vukovic
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OBESITY complications , *HYPERTENSION , *OBESITY , *SYSTEMATIC reviews , *BODY mass index , *INTRACRANIAL hypertension , *DISEASE complications - Abstract
Background: Idiopathic intracranial hypertension is characterized by increased intracranial pressure without any pathological findings on neuroimaging, except for signs of high intracranial pressure. Before diagnosing idiopathic intracranial hypertension secondary causes of increased intracranial pressure should be excluded.Objective: to characterize the phenotype of patients with secondary intracranial hypertension and to identify possible risk factors for secondary intracranial hypertension.Methods: We have systematically searched the PubMed database. The publications were analyzed according to the patient phenotype, age, gender, comorbidities, body mass index/weight status, and additional medication. The results are summarized in four categories: medication, infection, hormonal induced intracranial hypertension and miscellaneous groups of diseases related to sIH.Results: We identified 105 eligible papers which included 272 cases. There were 49.6% pediatric cases. Among the adult group,70.9% were women. A total of 40.4% of all cases were obese or overweight, 27% among adults and 13.4% among pediatric cases. Increased BMI and recent weight gain, anemia, renal diseases and hypertension were the most frequent comorbidities related to sIH.Conclusion: Among sIH patients, 40.4% were obese or overweight; two thirds were women. We recommend that even patients with a typical IIH phenotype should be screened for secondary causes. [ABSTRACT FROM AUTHOR]- Published
- 2022
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- View/download PDF
22. sj-pdf-1-cep-10.1177_0333102420944866 - Supplemental material for Neurofilament light chain as biomarker in idiopathic intracranial hypertension
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Beier, Dagmar, Korsbæk, Johanne Juhl, Madsen, Jonna Skov, Olsen, Dorte Aalund, Molander, Laleh Dehghani, Hagen, Snorre M, Teunissen, Charlotte, Beier, Christoph P, and Jensen, Rigmor Højland
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FOS: Psychology ,FOS: Clinical medicine ,170199 Psychology not elsewhere classified ,110319 Psychiatry (incl. Psychotherapy) ,110306 Endocrinology ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified ,110904 Neurology and Neuromuscular Diseases ,Neuroscience - Abstract
Supplemental material, sj-pdf-1-cep-10.1177_0333102420944866 for Neurofilament light chain as biomarker in idiopathic intracranial hypertension by Dagmar Beier, Johanne Juhl Korsbæk, Jonna Skov Madsen, Dorte Aalund Olsen, Laleh Dehghani Molander, Snorre M Hagen, Charlotte Teunissen, Christoph P Beier and Rigmor Højland Jensen in Cephalalgia
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- 2020
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23. sj-pdf-2-cep-10.1177_0333102420944866 - Supplemental material for Neurofilament light chain as biomarker in idiopathic intracranial hypertension
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Beier, Dagmar, Korsbæk, Johanne Juhl, Madsen, Jonna Skov, Olsen, Dorte Aalund, Molander, Laleh Dehghani, Hagen, Snorre M, Teunissen, Charlotte, Beier, Christoph P, and Jensen, Rigmor Højland
- Subjects
FOS: Psychology ,FOS: Clinical medicine ,170199 Psychology not elsewhere classified ,110319 Psychiatry (incl. Psychotherapy) ,110306 Endocrinology ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified ,110904 Neurology and Neuromuscular Diseases ,Neuroscience - Abstract
Supplemental material, sj-pdf-2-cep-10.1177_0333102420944866 for Neurofilament light chain as biomarker in idiopathic intracranial hypertension by Dagmar Beier, Johanne Juhl Korsbæk, Jonna Skov Madsen, Dorte Aalund Olsen, Laleh Dehghani Molander, Snorre M Hagen, Charlotte Teunissen, Christoph P Beier and Rigmor Højland Jensen in Cephalalgia
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- 2020
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24. Neurofilament light chain as biomarker in idiopathic intracranial hypertension
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Beier, Dagmar, Korsbæk, Johanne Juhl, Madsen, Jonna Skov, Olsen, Dorte Aalund, Molander, Laleh Dehghani, Hagen, Snorre M., Teunissen, Charlotte, Beier, Christoph P., Jensen, Rigmor Højland, Beier, Dagmar, Korsbæk, Johanne Juhl, Madsen, Jonna Skov, Olsen, Dorte Aalund, Molander, Laleh Dehghani, Hagen, Snorre M., Teunissen, Charlotte, Beier, Christoph P., and Jensen, Rigmor Højland
- Abstract
Background: Damage of the optic nerve is the major complication of idiopathic intracranial hypertension. A biomarker indicative for optic nerve damage would help identifying high-risk patients requiring surgical procedures. Here, we studied the potential of cerebrospinal fluid neurofilament to predict idiopathic intracranial hypertension-induced optic nerve damage. Methods: In two centers, serum and cerebrospinal fluid of 61 patients with clinically suspected idiopathic intracranial hypertension were prospectively collected. Neurofilament concentrations were measured and related to ophthalmological assessment. Results: The average cerebrospinal fluid neurofilament concentration in patients with moderate and severe papilledema was increased compared to patients with minor and no papilledema (1755 ± 3507 pg/ml vs. 244 ± 102 pg/ml; p < 0.001). Cerebrospinal fluid neurofilament concentrations correlated with the maximal lumbar puncture opening pressure (r = 0.67, p < 0.001). In patients fulfilling the Friedman criteria for idiopathic intracranial hypertension with or without papilledema (n = 35), development of bilateral visual field defects and bilateral atrophy of the optic nerve were associated with increased average age-adjusted cerebrospinal fluid neurofilament concentrations. At last follow-up (n = 30), 8/13 of patients with increased, but only 3/17 with normal, cerebrospinal fluid neurofilament had developed bilateral visual field defects and/or bilateral optic nerve atrophy resulting in a sensitivity of 72.7% and a specificity of 73.7% of cerebrospinal fluid neurofilament to detect permanent optic nerve damage. Conclusions: Cerebrospinal fluid neurofilament is a putative biomarker for optical nerve damage in idiopathic intracranial hypertension.
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- 2020
25. Magnetic Resonance Imaging Signs of Idiopathic Intracranial Hypertension.
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Beier, Dagmar, Korsbæk, Johanne Juhl, Bsteh, Gabriel, Macher, Stefan, Marik, Wolfgang, Pemp, Berthold, Yuan, Hsiangkuo, Nisar, Areeba, Høgedal, Lisbeth, Molander, Laleh Dehghani, Hagen, Snorre Malm, Beier, Christoph Patrick, Kristensen, Simon Bang, and Jensen, Rigmor Højland
- Published
- 2024
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26. Neurofilament light chain as biomarker in idiopathic intracranial hypertension
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Beier, Dagmar, primary, Korsbæk, Johanne Juhl, additional, Madsen, Jonna Skov, additional, Olsen, Dorte Aalund, additional, Molander, Laleh Dehghani, additional, Hagen, Snorre M, additional, Teunissen, Charlotte, additional, Beier, Christoph P, additional, and Jensen, Rigmor Højland, additional
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- 2020
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27. Are the ICHD-3 criteria for headache attributed to idiopathic intracranial hypertension valid? Headache phenotyping and field-testing in newly diagnosed idiopathic intracranial hypertension.
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Hansen NS, Korsbæk JJ, Yri HM, Jensen RH, and Beier D
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- Adult, Female, Humans, Male, Middle Aged, International Classification of Diseases, Prospective Studies, Headache diagnosis, Headache classification, Headache etiology, Phenotype, Pseudotumor Cerebri diagnosis, Pseudotumor Cerebri complications, Sensitivity and Specificity
- Abstract
Background: Headache burden is substantial in idiopathic intracranial hypertension. The classification of idiopathic intracranial hypertension headache by the International Classification of Headache Disorders (ICHD) is an important tool for research and clinical purposes., Methods: We phenotyped headaches and tested sensitivity and specificity of the ICHD-3 criteria for idiopathic intracranial hypertension headache in a prospective cohort of patients suspected of idiopathic intracranial hypertension at two tertiary headache centers., Results: Sensitivity was 93% and specificity was 100% of ICHD-3 criteria for idiopathic intracranial hypertension-related headache validated in idiopathic intracranial hypertension ( n = 140) and patients in whom idiopathic intracranial hypertension was suspected but disproven ( n = 103). The phenotype of new/worsened headaches related to idiopathic intracranial hypertension suspicion was equally migraine-like (p = 0.76) and tension-type-like (p = 0.08). Lumbar puncture opening pressure was higher ( p < 0.0001) and pulsatile tinnitus more frequent ( p < 0.0001) in idiopathic intracranial hypertension patients, but neither improved the applicability of the headache criteria, nor did papilledema., Conclusion: Headache phenotype is not distinct in idiopathic intracranial hypertension. ICHD-3 criteria for idiopathic intracranial hypertension headache are sensitive and specific, but simplicity can be improved without compromising accuracy. We propose that a new or worsened headache temporally related to active idiopathic intracranial hypertension is a sufficient criterion for idiopathic intracranial hypertension headache regardless of headache phenotype or accompanying symptoms, and that elements of idiopathic intracranial hypertension diagnostics (papilledema and opening pressure) be segregated from headache criteria. Trial Registration: ClinicalTrials.gov Identifier: NCT04032379., Competing Interests: Declaration of conflicting interestsThe authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: NSH received funding from the Novo Nordic Foundation during the conduction of the work and gave lectures for Pfizer, University of Southern Denmark, and University of Copenhagen. JJK received funding from the Lundbeck Foundation, Rigshospitalet-Glostrup, and Odense University hospital for the duration of the study. HMY received support from Abbvie for participation in non-related courses. RHJ gave lectures for Pfizer, Eli-Lilly, Merck, TEVA, Novartis, Lundbeck and Allergan; was investigator in clinical trials with Eli-Lilly, Novartis and Lundbeck. She is the Director of Danish Headache Center, Lifting The Global Burden of Headache and Founder of Master of Headache Disorders at University of Copenhagen and received research funding from University of Copenhagen, Rigshospitalet, Lundbeck Foundation, The Medical Society in Copenhagen, NovoNordisk Foundation and Tryg Foundation. DB gave lectures for TEVA, Novartis, Pfizer. Received travel support from Allergan, TEVA, Pfizer, Abbvie; was in advisory boards for Novartis, Lilly, Teva, Lundbeck, Pfizer, Abbvie and participated in clinical trials for TEVA, Lundbeck, Novartis, Lilly, Novo Nordic Foundation outside the submitted work. Received grants from Odense University Hospital and Rigshospitalet, University of Copenhagen during the conduction of the work.
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- 2024
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28. [Idiopathic intracranial hypertension].
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Korsbæk JJ, Beier D, Wegener M, Hamann S, Cvetkovic VV, and Jensen RH
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- Female, Humans, Incidence, Intracranial Pressure, Obesity, Vision Disorders, Intracranial Hypertension diagnosis, Intracranial Hypertension etiology, Pseudotumor Cerebri diagnosis, Pseudotumor Cerebri therapy
- Abstract
Idiopathic intracranial hypertension (IIH) is a challenging disease characterized by an increase in intracranial pressure which occurs without any known cause. The disease is mainly seen in obese females of child-bearing age. While originally described as rare, the incidence is increasing in parallel with pandemic obesity, and clinicians in all fields are increasingly likely to meet patients with IIH. The condition causes major morbidity due to chronic headache and visual loss if untreated. In the past ten years new diagnostic criteria and guidelines for management have been published.
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- 2021
29. Awareness, Diagnosis and Management of Idiopathic Intracranial Hypertension.
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Jensen RH, Vukovic-Cvetkovic V, Korsbaek JJ, Wegener M, Hamann S, and Beier D
- Abstract
The diagnosis and management of idiopathic intracranial hypertension (IIH) can be difficult and multiple medical subspecialities are often involved. Several national and international guidelines regarding the investigations and management of IIH have been published in recent years but still there is no consensus about the optimal organization of IIH-care. The objective of this review was to propose and describe a referral pathway and an organization scheme for diagnosis and management of IIH. An extensive search of existing literature was conducted and summarized. In total, 237 IIH-articles were identified and hereof 43 included. The clinical practice in our specialized IIH-clinic is characterized and described. We conclude that an educational campaign involving medical care providers and patients with chronic headaches is necessary. A detailed organizational proposal for a referral pathway and management of IIH patients based on the literature search and our clinical experience from a highly specialized IIH outpatient clinic is suggested and discussed.
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- 2021
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