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1,050 results on '"Koroshetz, Walter"'

1. The HEALthy Brain and Child Development Study (HBCD): NIH collaboration to understand the impacts of prenatal and early life experiences on brain development.

Author

Volkow, Nora, Gordon, Joshua, Bianchi, Diana, Chiang, Michael, Clayton, Janine, Klein, William, Koob, George, Koroshetz, Walter, Pérez-Stable, Eliseo, Simoni, Jane, Tromberg, Bruce, Woychik, Richard, Hommer, Rebecca, Spotts, Erica, Xu, Benjamin, Zehr, Julia, Cole, Katherine, Dowling, Gayathri, Freund, Michelle, Howlett, Katia, Jordan, Chloe, Murray, Traci, Pariyadath, Vani, Prabhakar, Janani, Rankin, Michele, Sarampote, Christopher, and Weiss, Susan

Subjects
Brain development, HBCD, Longitudinal, Neuroimaging, Prenatal substance use, Social determinants of health
Abstract

The human brain undergoes rapid development during the first years of life. Beginning in utero, a wide array of biological, social, and environmental factors can have lasting impacts on brain structure and function. To understand how prenatal and early life experiences alter neurodevelopmental trajectories and shape health outcomes, several NIH Institutes, Centers, and Offices collaborated to support and launch the HEALthy Brain and Child Development (HBCD) Study. The HBCD Study is a multi-site prospective longitudinal cohort study, that will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. Influenced by the success of the ongoing Adolescent Brain Cognitive DevelopmentSM Study (ABCD Study®) and in partnership with the NIH Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®, the HBCD Study aims to establish a diverse cohort of over 7000 pregnant participants to understand how early life experiences, including prenatal exposure to addictive substances and adverse social environments as well as their interactions with an individuals genes, can affect neurodevelopmental trajectories and outcomes. Knowledge gained from the HBCD Study will help identify targets for early interventions and inform policies that promote resilience and mitigate the neurodevelopmental effects of adverse childhood experiences and environments.

Published
2024

2. Beyond the symptom: the biology of fatigue.

Author

Raizen, David, Mullington, Janet, Anaclet, Christelle, Clarke, Gerard, Critchley, Hugo, Dantzer, Robert, Davis, Ronald, Drew, Kelly, Fessel, Josh, Fuller, Patrick, Gibson, Erin, Harrington, Mary, Ian Lipkin, W, Klerman, Elizabeth, Klimas, Nancy, Komaroff, Anthony, Koroshetz, Walter, Krupp, Lauren, Kuppuswamy, Anna, Lasselin, Julie, Lewis, Laura, Magistretti, Pierre, Matos, Heidi, Miaskowski, Christine, Miller, Andrew, Nath, Avindra, Nedergaard, Maiken, Opp, Mark, Ritchie, Marylyn, Rogulja, Dragana, Rolls, Asya, Salamone, John, Saper, Clifford, Whittemore, Vicky, Wylie, Glenn, Younger, Jarred, Zee, Phyllis, and Craig Heller, H

Subjects
Humans, Fatigue, Motivation, Biology
Abstract

A workshop titled Beyond the Symptom: The Biology of Fatigue was held virtually September 27-28, 2021. It was jointly organized by the Sleep Research Society and the Neurobiology of Fatigue Working Group of the NIH Blueprint Neuroscience Research Program. For access to the presentations and video recordings, see: https://neuroscienceblueprint.nih.gov/about/event/beyond-symptom-biology-fatigue. The goals of this workshop were to bring together clinicians and scientists who use a variety of research approaches to understand fatigue in multiple conditions and to identify key gaps in our understanding of the biology of fatigue. This workshop summary distills key issues discussed in this workshop and provides a list of promising directions for future research on this topic. We do not attempt to provide a comprehensive review of the state of our understanding of fatigue, nor to provide a comprehensive reprise of the many excellent presentations. Rather, our goal is to highlight key advances and to focus on questions and future approaches to answering them.

Published
2023

3. The All of Us Research Program is an opportunity to enhance the diversity of US biomedical research

Author

Bianchi, Diana W., Brennan, Patricia Flatley, Chiang, Michael F., Criswell, Lindsey A., D’Souza, Rena N., Gibbons, Gary H., Gilman, James K., Gordon, Joshua A., Green, Eric D., Gregurick, Susan, Hodes, Richard J., Kilmarx, Peter H., Koob, George F., Koroshetz, Walter J., Langevin, Helene M., Lorsch, Jon R., Marrazzo, Jeanne M., Pérez-Stable, Eliseo J., Rathmell, W. Kimryn, Rodgers, Griffin P., Rutter, Joni L., Simoni, Jane M., Tromberg, Bruce J., Tucci, Debara L., Volkow, Nora D., Woychik, Rick, Zenk, Shannon N., Kozlowski, Elyse, Peterson, Rachele S., Ginsburg, Geoffrey S., and Denny, Joshua C.

Published
2024
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4. The HEALthy Brain and Child Development Study (HBCD): NIH collaboration to understand the impacts of prenatal and early life experiences on brain development

Author

Volkow, Nora D., Gordon, Joshua A., Bianchi, Diana W., Chiang, Michael F., Clayton, Janine A., Klein, William M., Koob, George F., Koroshetz, Walter J., Pérez-Stable, Eliseo J., Simoni, Jane M., Tromberg, Bruce J., Woychik, Richard P., Hommer, Rebecca, Spotts, Erica L., Xu, Benjamin, Zehr, Julia L., Cole, Katherine M., Dowling, Gayathri J., Freund, Michelle P., Howlett, Katia D., Jordan, Chloe J., Murray, Traci M., Pariyadath, Vani, Prabhakar, Janani, Rankin, Michele L., Sarampote, Christopher S., and Weiss, Susan R.B.

Published
2024
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5. Current directions in tau research: Highlights from Tau 2020

Author

Sexton, Claire, Snyder, Heather, Beher, Dirk, Boxer, Adam L, Brannelly, Pat, Brion, Jean‐Pierre, Buée, Luc, Cacace, Angela M, Chételat, Gaël, Citron, Martin, DeVos, Sarah L, Diaz, Kristophe, Feldman, Howard H, Frost, Bess, Goate, Alison M, Gold, Michael, Hyman, Bradley, Johnson, Keith, Karch, Celeste M, Kerwin, Diana R, Koroshetz, Walter J, Litvan, Irene, Morris, Huw R, Mummery, Catherine J, Mutamba, James, Patterson, Marc C, Quiroz, Yakeel T, Rabinovici, Gil D, Rommel, Amy, Shulman, Melanie B, Toledo‐Sherman, Leticia M, Weninger, Stacie, Wildsmith, Kristin R, Worley, Susan L, and Carrillo, Maria C

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical Sciences, Neurosciences, Psychology, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Acquired Cognitive Impairment, Alzheimer's Disease, Dementia, Aging, Brain Disorders, Neurodegenerative, Alzheimer Disease, Biomarkers, Cognitive Dysfunction, Drug Discovery, Humans, tau Proteins, Alzheimer's, biomarkers, neurodegeneration, tau, therapeutics, Geriatrics, Clinical sciences, Biological psychology
Abstract

Studies supporting a strong association between tau deposition and neuronal loss, neurodegeneration, and cognitive decline have heightened the allure of tau and tau-related mechanisms as therapeutic targets. In February 2020, leading tau experts from around the world convened for the first-ever Tau2020 Global Conference in Washington, DC, co-organized and cosponsored by the Rainwater Charitable Foundation, the Alzheimer's Association, and CurePSP. Representing academia, industry, government, and the philanthropic sector, presenters and attendees discussed recent advances and current directions in tau research. The meeting provided a unique opportunity to move tau research forward by fostering global partnerships among academia, industry, and other stakeholders and by providing support for new drug discovery programs, groundbreaking research, and emerging tau researchers. The meeting also provided an opportunity for experts to present critical research-advancing tools and insights that are now rapidly accelerating the pace of tau research.

Published
2022

6. Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Author

Steinmetz, Jaimie D, Seeher, Katrin Maria, Schiess, Nicoline, Nichols, Emma, Cao, Bochen, Servili, Chiara, Cavallera, Vanessa, Cousin, Ewerton, Hagins, Hailey, Moberg, Madeline E, Mehlman, Max L, Abate, Yohannes Habtegiorgis, Abbas, Jaffar, Abbasi, Madineh Akram, Abbasian, Mohammadreza, Abbastabar, Hedayat, Abdelmasseh, Michael, Abdollahi, Mohammad, Abdollahi, Mozhan, Abdollahifar, Mohammad-Amin, Abd-Rabu, Rami, Abdulah, Deldar Morad, Abdullahi, Auwal, Abedi, Aidin, Abedi, Vida, Abeldańo Zuńiga, Roberto Ariel, Abidi, Hassan, Abiodun, Olumide, Aboagye, Richard Gyan, Abolhassani, Hassan, Aboyans, Victor, Abrha, Woldu Aberhe, Abualhasan, Ahmed, Abu-Gharbieh, Eman, Aburuz, Salahdein, Adamu, Lawan Hassan, Addo, Isaac Yeboah, Adebayo, Oladimeji M, Adekanmbi, Victor, Adekiya, Tayo Alex, Adikusuma, Wirawan, Adnani, Qorinah Estiningtyas Sakilah, Adra, Saryia, Afework, Tsion, Afolabi, Aanuoluwapo Adeyimika, Afraz, Ali, Afzal, Saira, Aghamiri, Shahin, Agodi, Antonella, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Sajjad, Ahmadzade, Amir Mahmoud, Ahmed, Ali, Ahmed, Ayman, Ahmed, Haroon, Ahmed, Jivan Qasim, Ahmed, Luai A, Ahmed, Muktar Beshir, Ahmed, Syed Anees, Ajami, Marjan, Aji, Budi, Ajumobi, Olufemi, Akade, Seyed Esma'il, Akbari, Morteza, Akbarialiabad, Hossein, Akhlaghi, Shiva, Akinosoglou, Karolina, Akinyemi, Rufus Olusola, Akonde, Maxwell, Al Hasan, Syed Mahfuz, Alahdab, Fares, AL-Ahdal, Tareq Mohammed Ali, Al-amer, Rasmieh Mustafa, Albashtawy, Mohammed, AlBataineh, Mohammad T, Aldawsari, Khalifah A, Alemi, Hediyeh, Alemi, Sharifullah, Algammal, Abdelazeem M, Al-Gheethi, Adel Ali Saeed, Alhalaiqa, Fadwa Alhalaiqa Naji, Alhassan, Robert Kaba, Ali, Abid, Ali, Endale Alemayehu, Ali, Liaqat, Ali, Mohammed Usman, Ali, Musa Mohammed, Ali, Rafat, Ali, Shahid, Ali, Syed Shujait Shujait, Ali, Zahid, Alif, Sheikh Mohammad, Alimohamadi, Yousef, Aliyi, Ahmednur Adem, Aljofan, Mohamad, Aljunid, Syed Mohamed, Alladi, Suvarna, Almazan, Joseph Uy, Almustanyir, Sami, Al-Omari, Basem, Alqahtani, Jaber S, Alqasmi, Ibrahim, Alqutaibi, Ahmed Yaseen, Al-Shahi Salman, Rustam, Altaany, Zaid, Al-Tawfiq, Jaffar A, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Al-Worafi, Yaser Mohammed, Aly, Hany, Aly, Safwat, Alzoubi, Karem H, Amani, Reza, Amindarolzarbi, Alireza, Amiri, Sohrab, Amirzade-Iranaq, Mohammad Hosein, Amu, Hubert, Amugsi, Dickson A, Amusa, Ganiyu Adeniyi, Amzat, Jimoh, Ancuceanu, Robert, Anderlini, Deanna, Anderson, David B, Andrei, Catalina Liliana, Androudi, Sofia, Angappan, Dhanalakshmi, Angesom, Teklit W, Anil, Abhishek, Ansari-Moghaddam, Alireza, Anwer, Razique, Arafat, Mosab, Aravkin, Aleksandr Y, Areda, Demelash, Ariffin, Hany, Arifin, Hidayat, Arkew, Mesay, Ärnlöv, Johan, Arooj, Mahwish, Artamonov, Anton A, Artanti, Kurnia Dwi, Aruleba, Raphael Taiwo, Asadi-Pooya, Ali A, Asena, Tilahun Ferede, Asghari-Jafarabadi, Mohammad, Ashraf, Muhammad, Ashraf, Tahira, Atalell, Kendalem Asmare, Athari, Seyyed Shamsadin, Atinafu, Bantalem Tilaye Tilaye, Atorkey, Prince, Atout, Maha Moh'd Wahbi, Atreya, Alok, Aujayeb, Avinash, Avan, Abolfazl, Ayala Quintanilla, Beatriz Paulina, Ayatollahi, Haleh, Ayinde, Olatunde O, Ayyoubzadeh, Seyed Mohammad, Azadnajafabad, Sina, Azizi, Zahra, Azizian, Khalil, Azzam, Ahmed Y, Babaei, Mahsa, Badar, Muhammad, Badiye, Ashish D, Baghdadi, Soroush, Bagherieh, Sara, Bai, Ruhai, Baig, Atif Amin, Balakrishnan, Senthilkumar, Balalla, Shivanthi, Baltatu, Ovidiu Constantin, Banach, Maciej, Bandyopadhyay, Soham, Banerjee, Indrajit, Baran, Mehmet Firat, Barboza, Miguel A, Barchitta, Martina, Bardhan, Mainak, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barrow, Amadou, Bashash, Davood, Bashiri, Hamideh, Bashiru, Hameed Akande, Basiru, Afisu, Basso, João Diogo, Basu, Sanjay, Batiha, Abdul-Monim Mohammad, Batra, Kavita, Baune, Bernhard T, Bedi, Neeraj, Begde, Ahmet, Begum, Tahmina, Behnam, Babak, Behnoush, Amir Hossein, Beiranvand, Maryam, Béjot, Yannick, Bekele, Alehegn, Belete, Melaku Ashagrie, Belgaumi, Uzma Iqbal, Bemanalizadeh, Maryam, Bender, Rose G, Benfor, Bright, Bennett, Derrick A, Bensenor, Isabela M, Berice, Betyna, Bettencourt, Paulo J G, Beyene, Kebede A, Bhadra, Abhishek, Bhagat, Devidas S, Bhangdia, Kayleigh, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhargava, Ashish, Bhaskar, Sonu, Bhat, Ajay Nagesh, Bhat, Vivek, Bhatti, Gurjit Kaur, Bhatti, Jasvinder Singh, Bhatti, Rajbir, Bijani, Ali, Bikbov, Boris, Bilalaga, Mariah Malak, Biswas, Atanu, Bitaraf, Saeid, Bitra, Veera R, Bjørge, Tone, Bodolica, Virginia, Bodunrin, Aadam Olalekan, Boloor, Archith, Braithwaite, Dejana, Brayne, Carol, Brenner, Hermann, Briko, Andrey, Bringas Vega, Maria L, Brown, Julie, Budke, Christine M, Buonsenso, Danilo, Burkart, Katrin, Burns, Richard A, Bustanji, Yasser, Butt, Muhammad Hammad, Butt, Nadeem Shafique, Butt, Zahid A, Cabral, Lucas Scotta, Caetano dos Santos, Florentino Luciano, Calina, Daniela, Campos-Nonato, Ismael R, Cao, Chao, Carabin, Hélène, Cárdenas, Rosario, Carreras, Giulia, Carvalho, Andre F, Castańeda-Orjuela, Carlos A, Casulli, Adriano, Catalá-López, Ferrán, Catapano, Alberico L, Caye, Arthur, Cegolon, Luca, Cenderadewi, Muthia, Cerin, Ester, Chacón-Uscamaita, Pamela R, Chan, Jeffrey Shi Kai, Chanie, Gashaw Sisay, Charan, Jaykaran, Chattu, Vijay Kumar, Chekol Abebe, Endeshaw, Chen, Hui, Chen, Jianqi, Chi, Gerald, Chichagi, Fatemeh, Chidambaram, Saravana Babu, Chimoriya, Ritesh, Ching, Patrick R, Chitheer, Abdulaal, Chong, Yuen Yu, Chopra, Hitesh, Choudhari, Sonali Gajanan, Chowdhury, Enayet Karim, Chowdhury, Rajiv, Christensen, Hanne, Chu, Dinh-Toi, Chukwu, Isaac Sunday, Chung, Eric, Coberly, Kaleb, Columbus, Alyssa, Comachio, Josielli, Conde, Joao, Cortesi, Paolo Angelo, Costa, Vera Marisa, Couto, Rosa A S, Criqui, Michael H, Cruz-Martins, Natália, Dabbagh Ohadi, Mohammad Amin, Dadana, Sriharsha, Dadras, Omid, Dai, Xiaochen, Dai, Zhaoli, D'Amico, Emanuele, Danawi, Hadi A, Dandona, Lalit, Dandona, Rakhi, Darwish, Amira Hamed, Das, Saswati, Das, Subasish, Dascalu, Ana Maria, Dash, Nihar Ranjan, Dashti, Mohsen, De la Hoz, Fernando Pio, de la Torre-Luque, Alejandro, De Leo, Diego, Dean, Frances E, Dehghan, Amin, Dehghan, Azizallah, Dejene, Hiwot, Demant, Daniel, Demetriades, Andreas K, Demissie, Solomon, Deng, Xinlei, Desai, Hardik Dineshbhai, Devanbu, Vinoth Gnana Chellaiyan, Dhama, Kuldeep, Dharmaratne, Samath Dhamminda, Dhimal, Meghnath, Dias da Silva, Diana, Diaz, Daniel, Dibas, Mahmoud, Ding, Delaney D, Dinu, Monica, Dirac, M Ashworth, Diress, Mengistie, Do, Thanh Chi, Do, Thao Huynh Phuong, Doan, Khanh Duy Khanh, Dodangeh, Milad, Doheim, Mohamed Fahmy, Dokova, Klara Georgieva, Dongarwar, Deepa, Dsouza, Haneil Larson, Dube, John, Duraisamy, Senbagam, Durojaiye, Oyewole Christopher, Dutta, Sulagna, Dziedzic, Arkadiusz Marian, Edinur, Hisham Atan, Eissazade, Negin, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, El Nahas, Nevine, El Sayed, Iman, Elahi Najafi, Mohammad Amin, Elbarazi, Iffat, Elemam, Noha Mousaad, Elgar, Frank J, Elgendy, Islam Y, Elhabashy, Hala Rashad, Elhadi, Muhammed, Elilo, Legesse Tesfaye, Ellenbogen, Richard G, Elmeligy, Omar Abdelsadek Abdou, Elmonem, Mohamed A, Elshaer, Mohammed, Elsohaby, Ibrahim, Emamverdi, Mehdi, Emeto, Theophilus I, Endres, Matthias, Esezobor, Christopher Imokhuede, Eskandarieh, Sharareh, Fadaei, Abdolmajid, Fagbamigbe, Adeniyi Francis, Fahim, Ayesha, Faramarzi, Ali, Fares, Jawad, Farjoud Kouhanjani, Mohsen, Faro, Andre, Farzadfar, Farshad, Fatehizadeh, Ali, Fathi, Mobina, Fathi, Saeid, Fatima, Syeda Anum Fatima, Feizkhah, Alireza, Fereshtehnejad, Seyed-Mohammad, Ferrari, Alize J, Ferreira, Nuno, Fetensa, Getahun, Firouraghi, Neda, Fischer, Florian, Fonseca, Ana Catarina, Force, Lisa M, Fornari, Arianna, Foroutan, Behzad, Fukumoto, Takeshi, Gadanya, Muktar A, Gaidhane, Abhay Motiramji, Galali, Yaseen, Galehdar, Nasrin, Gan, Quan, Gandhi, Aravind P, Ganesan, Balasankar, Gardner, William M, Garg, Naval, Gau, Shuo-Yan, Gautam, Rupesh K, Gebre, Teshome, Gebrehiwot, Mesfin, Gebremeskel, Gebreamlak Gebremedhn, Gebreslassie, Haftay Gebremedhin, Getacher, Lemma, Ghaderi Yazdi, Bardiya, Ghadirian, Fataneh, Ghaffarpasand, Fariborz, Ghanbari, Reza, Ghasemi, MohammadReza, Ghazy, Ramy Mohamed, Ghimire, Sailaja, Gholami, Ali, Gholamrezanezhad, Ali, Ghotbi, Elena, Ghozy, Sherief, Gialluisi, Alessandro, Gill, Paramjit Singh, Glasstetter, Logan M, Gnedovskaya, Elena V, Golchin, Ali, Golechha, Mahaveer, Goleij, Pouya, Golinelli, Davide, Gomes-Neto, Mansueto, Goulart, Alessandra C, Goyal, Anmol, Gray, Richard J, Grivna, Michal, Guadie, Habtamu Alganeh, Guan, Bin, Guarducci, Giovanni, Guicciardi, Stefano, Gunawardane, Damitha Asanga, Guo, Hanbing, Gupta, Bhawna, Gupta, Rajeev, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vivek Kumar, Gutiérrez, Reyna Alma, Habibzadeh, Farrokh, Hachinski, Vladimir, Haddadi, Rasool, Hadei, Mostafa, Hadi, Najah R, Haep, Nils, Haile, Teklehaimanot Gereziher, Haj-Mirzaian, Arvin, Hall, Brian J, Halwani, Rabih, Hameed, Sajid, Hamiduzzaman, Mohammad, Hammoud, Ahmad, Han, Hannah, Hanifi, Nasrin, Hankey, Graeme J, Hannan, Md. Abdul, Hao, Junwei, Harapan, Harapan, Hareru, Habtamu Endashaw, Hargono, Arief, Harlianto, Netanja I., Haro, Josep Maria, Hartman, Nicholas Nathaniel, Hasaballah, Ahmed I., Hasan, Faizul, Hasani, Hamidreza, Hasanian, Mohammad, Hassan, Amr, Hassan, Shoaib, Hassanipour, Soheil, Hassankhani, Hadi, Hassen, Mohammed Bheser, Haubold, Johannes, Hay, Simon I, Hayat, Khezar, Hegazy, Mohamed I, Heidari, Golnaz, Heidari, Mohammad, Heidari-Soureshjani, Reza, Hesami, Hamed, Hezam, Kamal, Hiraike, Yuta, Hoffman, Howard J, Holla, Ramesh, Hopf, Kathleen Pillsbury, Horita, Nobuyuki, Hossain, Md Mahbub, Hossain, Md. Belal, Hossain, Sahadat, Hosseinzadeh, Hassan, Hosseinzadeh, Mehdi, Hostiuc, Sorin, Hu, Chengxi, Huang, Junjie, Huda, Md. Nazmul, Hussain, Javid, Hussein, Nawfal R, Huynh, Hong-Han, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Ilaghi, Mehran, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Immurana, Mustapha, Iravanpour, Farideh, Islam, Sheikh Mohammed Shariful, Ismail, Faisal, Iso, Hiroyasu, Isola, Gaetano, Iwagami, Masao, Iwu, Chidozie C D, Iyer, Mahalaxmi, Jaan, Ali, Jacob, Louis, Jadidi-Niaragh, Farhad, Jafari, Mahboobeh, Jafarinia, Morteza, Jafarzadeh, Abdollah, Jahankhani, Kasra, Jahanmehr, Nader, Jahrami, Haitham, Jaiswal, Abhishek, Jakovljevic, Mihajlo, Jamora, Roland Dominic G, Jana, Somnath, Javadi, Nilofer, Javed, Saad, Javeed, Saad, Jayapal, Sathish Kumar, Jayaram, Shubha, Jiang, Heng, Johnson, Catherine Owens, Johnson, Walter D, Jokar, Mohammad, Jonas, Jost B, Joseph, Abel, Joseph, Nitin, Joshua, Charity Ehimwenma, Jürisson, Mikk, Kabir, Ali, Kabir, Zubair, Kabito, Gebisa Guyasa, Kadashetti, Vidya, Kafi, Fatemeh, Kalani, Rizwan, Kalantar, Farnaz, Kaliyadan, Feroze, Kamath, Ashwin, Kamath, Sagarika, Kanchan, Tanuj, Kandel, Amit, Kandel, Himal, Kanmodi, Kehinde Kazeem, Karajizadeh, Mehrdad, Karami, Jafar, Karanth, Shama D, Karaye, Ibraheem M, Karch, André, Karimi, Aliasghar, Karimi, Hanie, Karimi Behnagh, Arman, Kasraei, Hengameh, Kassebaum, Nicholas J, Kauppila, Joonas H, Kaur, Harkiran, Kaur, Navjot, Kayode, Gbenga A, Kazemi, Foad, Keikavoosi-Arani, Leila, Keller, Cathleen, Keykhaei, Mohammad, Khadembashiri, Mohammad Amin, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khajuria, Himanshu, Khalaji, Amirmohammad, Khamesipour, Faham, Khammarnia, Mohammad, Khan, Maseer, Khan, Moien AB, Khan, Yusra H, Khan Suheb, Mahammed Ziauddin, Khanmohammadi, Shaghayegh, Khanna, Tripti, Khatab, Khaled, Khatatbeh, Haitham, Khatatbeh, Moawiah Mohammad, Khateri, Sorour, Khatib, Mahalaqua Nazli, Khayat Kashani, Hamid Reza, Khonji, Mohammad Saeid, khorashadizadeh, Fatemeh, Khormali, Moein, Khubchandani, Jagdish, Kian, Saeid, Kim, Grace, Kim, Jihee, Kim, Min Seo, Kim, Yun Jin, Kimokoti, Ruth W, Kisa, Adnan, Kisa, Sezer, Kivimäki, Mika, Kochhar, Sonali, Kolahi, Ali-Asghar, Koly, Kamrun Nahar, Kompani, Farzad, Koroshetz, Walter J, Kosen, Soewarta, Kourosh Arami, Masoumeh, Koyanagi, Ai, Kravchenko, Michael A, Krishan, Kewal, Krishnamoorthy, Vijay, Kuate Defo, Barthelemy, Kuddus, Md Abdul, Kumar, Ashish, Kumar, G Anil, Kumar, Manasi, Kumar, Nithin, Kumsa, Netsanet Bogale, Kundu, Satyajit, Kurniasari, Maria Dyah, Kusuma, Dian, Kuttikkattu, Ambily, Kyu, Hmwe Hmwe, La Vecchia, Carlo, Ladan, Muhammad Awwal, Lahariya, Chandrakant, Laksono, Tri, Lal, Dharmesh Kumar, Lallukka, Tea, Lám, Judit, Lami, Faris Hasan, Landires, Iván, Langguth, Berthold, Lasrado, Savita, Latief, Kamaluddin, Latifinaibin, Kaveh, Lau, Kathryn Mei-Ming, Laurens, Matthew B, Lawal, Basira Kankia, Le, Long Khanh Dao, Le, Thao Thi Thu, Ledda, Caterina, Lee, Munjae, Lee, Sang-woong, Lee, Seung Won, Lee, Wei-Chen, Lee, Yo Han, Leonardi, Matilde, Lerango, Temesgen L, Li, Ming-Chieh, Li, Wei, Ligade, Virendra S, Lim, Stephen S, Linehan, Christine, Liu, Chaojie, Liu, Jue, Liu, Wei, Lo, Chun-Han, Lo, Warren David, Lobo, Stany W, Logroscino, Giancarlo, Lopes, Graciliana, Lopukhov, Platon D, Lorenzovici, László, Lorkowski, Stefan, Loureiro, Joana A, Lubinda, Jailos, Lucchetti, Giancarlo, Lutzky Saute, Ricardo, Ma, Zheng Feei, Mabrok, Mahmoud, Machoy, Monika, Madadizadeh, Farzan, Magdy Abd El Razek, Mohammed, Maghazachi, Azzam A, Maghbouli, Nastaran, Mahjoub, Soleiman, Mahmoudi, Morteza, Majeed, Azeem, Malagón-Rojas, Jeadran N., Malakan Rad, Elaheh, Malhotra, Kashish, Malik, Ahmad Azam, Malik, Iram, Mallhi, Tauqeer Hussain, Malta, Deborah Carvalho, Manilal, Aseer, Mansouri, Vahid, Mansournia, Mohammad Ali, Marasini, Bishnu P, Marateb, Hamid Reza, Maroufi, Seyed Farzad, Martinez-Raga, Jose, Martini, Santi, Martins-Melo, Francisco Rogerlândio, Martorell, Miquel, März, Winfried, Marzo, Roy Rillera, Massano, João, Mathangasinghe, Yasith, Mathews, Elezebeth, Maude, Richard James, Maugeri, Andrea, Maulik, Pallab K, Mayeli, Mahsa, Mazaheri, Maryam, McAlinden, Colm, McGrath, John J, Meena, Jitendra Kumar, Mehndiratta, Man Mohan, Mendez-Lopez, Max Alberto Mendez, Mendoza, Walter, Mendoza-Cano, Oliver, Menezes, Ritesh G, Merati, Mohsen, Meretoja, Atte, Merkin, Alexander, Mersha, Abera M, Mestrovic, Tomislav, Mi, Tianyue, Miazgowski, Tomasz, Michalek, Irmina Maria, Mihretie, Ephrem Tesfaye, Minh, Le Huu Nhat, Mirfakhraie, Reza, Mirica, Andreea, Mirrakhimov, Erkin M, Mirzaei, Mehdi, Misganaw, Awoke, Misra, Sanjeev, Mithra, Prasanna, Mizana, Biru Abdissa, Mohamadkhani, Ashraf, Mohamed, Nouh Saad, Mohammadi, Esmaeil, Mohammadi, Hiwa, Mohammadi, Shadieh, Mohammadi, Soheil, Mohammadshahi, Marita, Mohammed, Mustapha, Mohammed, Salahuddin, Mohammed, Shafiu, Mohan, Syam, Mojiri-forushani, Hoda, Moka, Nagabhishek, Mokdad, Ali H, Molinaro, Sabrina, Möller, Holger, Monasta, Lorenzo, Moniruzzaman, Md, Montazeri, Fateme, Moradi, Maryam, Moradi, Yousef, Moradi-Lakeh, Maziar, Moraga, Paula, Morovatdar, Negar, Morrison, Shane Douglas, Mosapour, Abbas, Mosser, Jonathan F, Mossialos, Elias, Motaghinejad, Majid, Mousavi, Parsa, Mousavi, Seyed Ehsan, Mubarik, Sumaira, Muccioli, Lorenzo, Mughal, Faraz, Mukoro, George Duke, Mulita, Admir, Mulita, Francesk, Musaigwa, Fungai, Mustafa, Ahmad, Mustafa, Ghulam, Muthu, Sathish, Nagarajan, Ahamarshan Jayaraman, Naghavi, Pirouz, Naik, Ganesh R, Nainu, Firzan, Nair, Tapas Sadasivan, Najmuldeen, Hastyar Hama Rashid, Nakhostin Ansari, Noureddin, Nambi, Gopal, Namdar Areshtanab, Hossein, Nargus, Shumaila, Nascimento, Bruno Ramos, Naser, Abdallah Y, Nashwan, Abdulqadir J J, Nasoori, Hadis, Nasreldein, Ahmed, Natto, Zuhair S, Nauman, Javaid, Nayak, Biswa Prakash, Nazri-Panjaki, Athare, Negaresh, Mohammad, Negash, Hadush, Negoi, Ionut, Negoi, Ruxandra Irina, Negru, Serban Mircea, Nejadghaderi, Seyed Aria, Nematollahi, Mohammad Hadi, Nesbit, Olivia D, Newton, Charles Richard James, Nguyen, Dang H, Nguyen, Hau Thi Hien, Nguyen, Hien Quang, Nguyen, Ngoc-Trinh Thi, Nguyen, Phat Tuan, Nguyen, Van Thanh, Niazi, Robina Khan, Nikolouzakis, Taxiarchis Konstantinos, Niranjan, Vikram, Nnyanzi, Lawrence Achilles, Noman, Efaq Ali, Noroozi, Nafise, Norrving, Bo, Noubiap, Jean Jacques, Nri-Ezedi, Chisom Adaobi, Ntaios, George, Nuńez-Samudio, Virginia, Nurrika, Dieta, Oancea, Bogdan, Odetokun, Ismail A, O'Donnell, Martin James, Ogunsakin, Ropo Ebenezer, Oguta, James Odhiambo, Oh, In-Hwan, Okati-Aliabad, Hassan, Okeke, Sylvester Reuben, Okekunle, Akinkunmi Paul, Okonji, Osaretin Christabel, Okwute, Patrick Godwin, Olagunju, Andrew T, Olaiya, Muideen Tunbosun, Olana, Matifan Dereje, Olatubi, Matthew Idowu, Oliveira, Gláucia Maria Moraes, Olufadewa, Isaac Iyinoluwa, Olusanya, Bolajoko Olubukunola, Omar Bali, Ahmed, Ong, Sokking, Onwujekwe, Obinna E, Ordak, Michal, Orji, Aislyn U, Ortega-Altamirano, Doris V, Osuagwu, Uchechukwu Levi, Otstavnov, Nikita, Otstavnov, Stanislav S, Ouyahia, Amel, Owolabi, Mayowa O, P A, Mahesh Padukudru, Pacheco-Barrios, Kevin, Padubidri, Jagadish Rao, Pal, Pramod Kumar, Palange, Padmavali Nanaji, Palladino, Claudia, Palladino, Raffaele, Palma-Alvarez, Raul Felipe, Pan, Feng, Panagiotakos, Demosthenes, Panda-Jonas, Songhomitra, Pandey, Anamika, Pandey, Ashok, Pandian, Jeyaraj Durai, Pangaribuan, Helena Ullyartha, Pantazopoulos, Ioannis, Pardhan, Shahina, Parija, Pragyan Paramita, Parikh, Romil R, Park, Seoyeon, Parthasarathi, Ashwaghosha, Pashaei, Ava, Patel, Jay, Patil, Shankargouda, Patoulias, Dimitrios, Pawar, Shrikant, Pedersini, Paolo, Pensato, Umberto, Pereira, David M, Pereira, Jeevan, Pereira, Maria Odete, Peres, Mario F P, Perico, Norberto, Perna, Simone, Petcu, Ionela-Roxana, Petermann-Rocha, Fanny Emily, Pham, Hoang Tran, Phillips, Michael R, Pinilla-Monsalve, Gabriel D, Piradov, Michael A, Plotnikov, Evgenii, Poddighe, Dimitri, Polat, Burcu, Poluru, Ramesh, Pond, Constance Dimity, Poudel, Govinda Raj, Pouramini, Alireza, Pourbagher-Shahri, Ali Mohammad, Pourfridoni, Mohammad, Pourtaheri, Naeimeh, Prakash, Peralam Yegneswaran, Prakash, Sanjay, Prakash, V, Prates, Elton Junio Sady, Pritchett, Natalie, Purnobasuki, Hery, Qasim, Nameer Hashim, Qattea, Ibrahim, Qian, Gangzhen, Radhakrishnan, Venkatraman, Raee, Pourya, Raeisi Shahraki, Hadi, Rafique, Ibrar, Raggi, Alberto, Raghav, Pankaja Raghav, Rahati, Meghdad M, Rahim, Fakher, Rahimi, Zahra, Rahimifard, Mahban, Rahman, Md Obaidur, Rahman, Mohammad Hifz Ur, Rahman, Mosiur, Rahman, Muhammad Aziz, Rahmani, Amir Masoud, Rahmani, Shayan, Rahmani Youshanlouei, Hamed, Rahmati, Masoud, Raj Moolambally, Sheetal, Rajabpour-Sanati, Ali, Ramadan, Hazem, Ramasamy, Shakthi Kumaran, Ramasubramani, Premkumar, Ramazanu, Sheena, Rancic, Nemanja, Rao, Indu Ramachandra, Rao, Sowmya J, Rapaka, Deepthi, Rashedi, Vahid, Rashid, Ahmed Mustafa, Rashidi, Mohammad-Mahdi, Rashidi Alavijeh, Mehran, Rasouli-Saravani, Ashkan, Rawaf, Salman, Razo, Christian, Redwan, Elrashdy Moustafa Mohamed, Rekabi Bana, Atefe, Remuzzi, Giuseppe, Rezaei, Nazila, Rezaei, Negar, Rezaei, Nima, Rezaeian, Mohsen, Rhee, Taeho Gregory, Riad, Abanoub, Robinson, Stephen R, Rodrigues, Mónica, Rodriguez, Jefferson Antonio Buendia, Roever, Leonardo, Rogowski, Emma L B, Romoli, Michele, Ronfani, Luca, Roy, Priyanka, Roy Pramanik, Koushik, Rubagotti, Enrico, Ruiz, Milagros A, Russ, Tom C, S Sunnerhagen, Katharina, Saad, Aly M A, Saadatian, Zahra, Saber, Korosh, SaberiKamarposhti, Morteza, Sacco, Simona, Saddik, Basema, Sadeghi, Erfan, Sadeghian, Saeid, Saeed, Umar, Saeed, Usman, Safdarian, Mahdi, Safi, Sher Zaman, Sagar, Rajesh, Sagoe, Dominic, Saheb Sharif-Askari, Fatemeh, Saheb Sharif-Askari, Narjes, Sahebkar, Amirhossein, Sahoo, Soumya Swaroop, Sahraian, Mohammad Ali, Sajedi, Seyed Aidin, Sakshaug, Joseph W, Saleh, Mohamed A, Salehi Omran, Hossein, Salem, Marwa Rashad, Salimi, Sohrab, Samadi Kafil, Hossein, Samadzadeh, Sara, Samargandy, Saad, Samodra, Yoseph Leonardo, Samuel, Vijaya Paul, Samy, Abdallah M, Sanadgol, Nima, Sanjeev, Rama Krishna, Sanmarchi, Francesco, Santomauro, Damian Francesco, Santri, Ichtiarini Nurullita, Santric-Milicevic, Milena M, Saravanan, Aswini, Sarveazad, Arash, Satpathy, Maheswar, Saylan, Mete, Sayyah, Mehdi, Scarmeas, Nikolaos, Schlaich, Markus P, Schuermans, Art, Schwarzinger, Michaël, Schwebel, David C, Selvaraj, Siddharthan, Sendekie, Ashenafi Kibret, Sengupta, Pallav, Senthilkumaran, Subramanian, Serban, Dragos, Sergindo, Mihretu Tagesse, Sethi, Yashendra, SeyedAlinaghi, SeyedAhmad, Seylani, Allen, Shabani, Mohammad, Shabany, Maryam, Shafie, Mahan, Shahabi, Saeed, Shahbandi, Ataollah, Shahid, Samiah, Shahraki-Sanavi, Fariba, Shahsavari, Hamid R, Shahwan, Moyad Jamal, Shaikh, Masood Ali, Shaji, KS, Sham, Sunder, Shama, Adisu Tafari T, Shamim, Muhammad Aaqib, Shams-Beyranvand, Mehran, Shamsi, Mohammad Anas, Shanawaz, Mohd, Sharath, Medha, Sharfaei, Sadaf, Sharifan, Amin, Sharma, Manoj, Sharma, Rajesh, Shashamo, Bereket Beyene, Shayan, Maryam, Sheikhi, Rahim Ali, Shekhar, Shashank, Shen, Jiabin, Shenoy, Suchitra M, Shetty, Pavanchand H, Shiferaw, Desalegn Shiferaw, Shigematsu, Mika, Shiri, Rahman, Shittu, Aminu, Shivakumar, K M, Shokri, Fereshteh, Shool, Sina, Shorofi, Seyed Afshin, Shrestha, Sunil, Siankam Tankwanchi, Akhenaten Benjamin, Siddig, Emmanuel Edwar, Sigfusdottir, Inga Dora, Silva, João Pedro, Silva, Luís Manuel Lopes Rodrigues, Sinaei, Ehsan, Singh, Balbir Bagicha, Singh, Garima, Singh, Paramdeep, Singh, Surjit, Sirota, Sarah Brooke, Sivakumar, Shravan, Sohag, Abdullah Al Mamun, Solanki, Ranjan, Soleimani, Hamidreza, Solikhah, Solikhah, Solomon, Yerukneh, Solomon, Yonatan, Song, Suhang, Song, Yimeng, Sotoudeh, Houman, Spartalis, Michael, Stark, Benjamin A, Starnes, Joseph R, Starodubova, Antonina V, Stein, Dan J, Steiner, Timothy J, Stovner, Lars Jacob, Suleman, Muhammad, Suliankatchi Abdulkader, Rizwan, Sultana, Abida, Sun, Jing, Sunkersing, David, Sunny, Angel, Susianti, Hani, Swain, Chandan Kumar, Szeto, Mindy D, Tabarés-Seisdedos, Rafael, Tabatabaei, Seyyed Mohammad, Tabatabai, Shima, Tabish, Mohammad, Taheri, Majid, Tahvildari, Azin, Tajbakhsh, Ardeshir, Tampa, Mircea, Tamuzi, Jacques JL Lukenze, Tan, Ker-Kan, Tang, Haosu, Tareke, Minale, Tarigan, Ingan Ukur, Tat, Nathan Y, Tat, Vivian Y, Tavakoli Oliaee, Razieh, Tavangar, Seyed Mohammad, Tavasol, Arian, Tefera, Yibekal Manaye, Tehrani-Banihashemi, Arash, Temesgen, Worku Animaw, Temsah, Mohamad-Hani, Teramoto, Masayuki, Tesfaye, Amensisa Hailu, Tesfaye, Edosa Geta, Tesler, Riki, Thakali, Ocean, Thangaraju, Pugazhenthan, Thapa, Rajshree, Thapar, Rekha, Thomas, Nikhil Kenny, Thrift, Amanda G, Ticoalu, Jansje Henny Vera, Tillawi, Tala, Toghroli, Razie, Tonelli, Marcello, Tovani-Palone, Marcos Roberto, Traini, Eugenio, Tran, Nghia Minh, Tran, Ngoc-Ha, Tran, Phu Van, Tromans, Samuel Joseph, Truelsen, Thomas Clement, Truyen, Thien Tan Tri Tai, Tsatsakis, Aristidis, Tsegay, Guesh Mebrahtom, Tsermpini, Evangelia Eirini, Tualeka, Abdul Rohim, Tufa, Derara Girma, Ubah, Chukwudi S, Udoakang, Aniefiok John, Ulhaq, Inam, Umair, Muhammad, Umakanthan, Srikanth, Umapathi, Krishna Kishore, Unim, Brigid, Unnikrishnan, Bhaskaran, Vaithinathan, Asokan Govindaraj, Vakilian, Alireza, Valadan Tahbaz, Sahel, Valizadeh, Rohollah, Van den Eynde, Jef, Vart, Priya, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Vaziri, Siavash, Vellingiri, Balachandar, Venketasubramanian, Narayanaswamy, Verras, Georgios-Ioannis, Vervoort, Dominique, Villafańe, Jorge Hugo, Villani, Leonardo, Vinueza Veloz, Andres Fernando, Viskadourou, Maria, Vladimirov, Sergey Konstantinovitch, Vlassov, Vasily, Volovat, Simona Ruxandra, Vu, Loc Tri, Vujcic, Isidora S, Wagaye, Birhanu, Waheed, Yasir, Wahood, Waseem, Walde, Mandaras Tariku, Wang, Fang, Wang, Shu, Wang, Yanzhong, Wang, Yuan-Pang, Waqas, Muhammad, Waris, Abdul, Weerakoon, Kosala Gayan, Weintraub, Robert G, Weldemariam, Abrha Hailay, Westerman, Ronny, Whisnant, Joanna L, Wickramasinghe, Dakshitha Praneeth, Wickramasinghe, Nuwan Darshana, Willekens, Barbara, Wilner, Lauren B, Winkler, Andrea Sylvia, Wolfe, Charles D A, Wu, Ai-Min, Wulf Hanson, Sarah, Xu, Suowen, Xu, Xiaoyue, Yadollahpour, Ali, Yaghoubi, Sajad, Yahya, Galal, Yamagishi, Kazumasa, Yang, Lin, Yano, Yuichiro, Yao, Yao, Yehualashet, Sisay Shewasinad, Yeshaneh, Alex, Yesiltepe, Metin, Yi, Siyan, Yiğit, Arzu, Yiğit, Vahit, Yon, Dong Keon, Yonemoto, Naohiro, You, Yuyi, Younis, Mustafa Z, Yu, Chuanhua, Yusuf, Hadiza, Zadey, Siddhesh, Zahedi, Mohammad, Zakham, Fathiah, Zaki, Nazar, Zali, Alireza, Zamagni, Giulia, Zand, Ramin, Zandieh, Ghazal G Z, Zangiabadian, Moein, Zarghami, Amin, Zastrozhin, Mikhail Sergeevich, Zeariya, Mohammed G M, Zegeye, Zelalem Banjaw, Zeukeng, Francis, Zhai, Chunxia, Zhang, Chen, Zhang, Haijun, Zhang, Yunquan, Zhang, Zhi-Jiang, Zhao, Hanqing, Zhao, Yang, Zheng, Peng, Zhou, Hengxing, Zhu, Bin, Zhumagaliuly, Abzal, Zielińska, Magdalena, Zikarg, Yossef Teshome, Zoladl, Mohammad, Murray, Christopher J L, Ong, Kanyin Liane, Feigin, Valery L, Vos, Theo, and Dua, Tarun

Published
2024
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7. Current directions in tau research: Highlights from Tau 2020.

Author

Sexton, Claire, Snyder, Heather, Beher, Dirk, Boxer, Adam L, Brannelly, Pat, Brion, Jean-Pierre, Buée, Luc, Cacace, Angela M, Chételat, Gaël, Citron, Martin, DeVos, Sarah L, Diaz, Kristophe, Feldman, Howard H, Frost, Bess, Goate, Alison M, Gold, Michael, Hyman, Bradley, Johnson, Keith, Karch, Celeste M, Kerwin, Diana R, Koroshetz, Walter J, Litvan, Irene, Morris, Huw R, Mummery, Catherine J, Mutamba, James, Patterson, Marc C, Quiroz, Yakeel T, Rabinovici, Gil D, Rommel, Amy, Shulman, Melanie B, Toledo-Sherman, Leticia M, Weninger, Stacie, Wildsmith, Kristin R, Worley, Susan L, and Carrillo, Maria C

Subjects
Alzheimer's, biomarkers, neurodegeneration, tau, therapeutics, Brain Disorders, Aging, Acquired Cognitive Impairment, Alzheimer's Disease, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurosciences, Dementia, Neurodegenerative, Geriatrics, Clinical Sciences
Abstract

Studies supporting a strong association between tau deposition and neuronal loss, neurodegeneration, and cognitive decline have heightened the allure of tau and tau-related mechanisms as therapeutic targets. In February 2020, leading tau experts from around the world convened for the first-ever Tau2020 Global Conference in Washington, DC, co-organized and cosponsored by the Rainwater Charitable Foundation, the Alzheimer's Association, and CurePSP. Representing academia, industry, government, and the philanthropic sector, presenters and attendees discussed recent advances and current directions in tau research. The meeting provided a unique opportunity to move tau research forward by fostering global partnerships among academia, industry, and other stakeholders and by providing support for new drug discovery programs, groundbreaking research, and emerging tau researchers. The meeting also provided an opportunity for experts to present critical research-advancing tools and insights that are now rapidly accelerating the pace of tau research.

Published
2021

8. The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy

Author

Bieniek, Kevin F, Cairns, Nigel J, Crary, John F, Dickson, Dennis W, Folkerth, Rebecca D, Keene, C Dirk, Litvan, Irene, Perl, Daniel P, Stein, Thor D, Vonsattel, Jean-Paul, Stewart, William, Dams-O’Connor, Kristen, Gordon, Wayne A, Tripodis, Yorghos, Alvarez, Victor E, Mez, Jesse, Alosco, Michael L, McKee, Ann C, Group, the TBI CTE Research, Babcock, Debra, Bellgowan, Patrick, Crane, Paul, Edlow, Brian, Huber, Bertrand Russ, Kiernan, Patrick, and Koroshetz, Walter

Subjects
Acquired Cognitive Impairment, Neurodegenerative, Basic Behavioral and Social Science, Brain Disorders, Behavioral and Social Science, Neurosciences, Adult, Aged, Aged, 80 and over, Chronic Traumatic Encephalopathy, Female, Humans, Male, Middle Aged, National Institute of Biomedical Imaging and Bioengineering (U.S.), National Institute of Neurological Disorders and Stroke (U.S.), Neuropathology, Single-Blind Method, United States, Young Adult, Brain trauma, Chronic traumatic encephalopathy, Neurodegenerative disorders, Tauopathy, Traumatic brain injury, TBI/CTE Research Group, Clinical Sciences, Neurology & Neurosurgery
Abstract

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB defined preliminary consensus neuropathological criteria for CTE, including the pathognomonic lesion of CTE as "an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed around small blood vessels at the depths of cortical sulci and in an irregular pattern," based on review of 25 tauopathy cases. In 2016, the consensus panel met again to review and refine the preliminary criteria, with consideration around the minimum threshold for diagnosis and the reproducibility of a proposed pathological staging scheme. Eight neuropathologists evaluated 27 cases of tauopathies (17 CTE cases), blinded to clinical and demographic information. Generalized estimating equation analyses showed a statistically significant association between the raters and CTE diagnosis for both the blinded (OR = 72.11, 95% CI = 19.5-267.0) and unblinded rounds (OR = 256.91, 95% CI = 63.6-1558.6). Based on the challenges in assigning CTE stage, the panel proposed a working protocol including a minimum threshold for CTE diagnosis and an algorithm for the assessment of CTE severity as "Low CTE" or "High CTE" for use in future clinical, pathological, and molecular studies.

Published
2021

9. Erratum: Litvina et al., “BRAIN Initiative: Cutting-Edge Tools and Resources for the Community”

Author

Litvina, Elizabeth, Adams, Amy, Barth, Alison, Bruchez, Marcel, Carson, James, Chung, Jason E, Dupre, Kristin B, Frank, Loren M, Gates, Kathleen M, Harris, Kristen M, Joo, Hannah, Lichtman, Jeff William, Ramos, Khara M, Sejnowski, Terrence, Trimmer, James S, White, Samantha, and Koroshetz, Walter

Subjects
Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Published
2020

10. BRAIN Initiative: Cutting-Edge Tools and Resources for the Community

Author

Litvina, Elizabeth, Adams, Amy, Barth, Alison, Bruchez, Marcel, Carson, James, Chung, Jason E, Dupre, Kristin B, Frank, Loren M, Gates, Kathleen M, Harris, Kristen M, Joo, Hannah, Lichtman, Jeff William, Ramos, Khara M, Sejnowski, Terrence, Trimmer, James S, White, Samantha, and Koroshetz, Walter

Subjects
Brain Disorders, Neurosciences, 1.1 Normal biological development and functioning, Underpinning research, Neurological, Humans, Research, Technology, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

The overarching goal of the NIH BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative is to advance the understanding of healthy and diseased brain circuit function through technological innovation. Core principles for this goal include the validation and dissemination of the myriad innovative technologies, tools, methods, and resources emerging from BRAIN-funded research. Innovators, BRAIN funding agencies, and non-Federal partners are working together to develop strategies for making these products usable, available, and accessible to the scientific community. Here, we describe several early strategies for supporting the dissemination of BRAIN technologies. We aim to invigorate a dialogue with the neuroscience research and funding community, interdisciplinary collaborators, and trainees about the existing and future opportunities for cultivating groundbreaking research products into mature, integrated, and adaptable research systems. Along with the accompanying Society for Neuroscience 2019 Mini-Symposium, "BRAIN Initiative: Cutting-Edge Tools and Resources for the Community," we spotlight the work of several BRAIN investigator teams who are making progress toward providing tools, technologies, and services for the neuroscience community. These tools access neural circuits at multiple levels of analysis, from subcellular composition to brain-wide network connectivity, including the following: integrated systems for EM- and florescence-based connectomics, advances in immunolabeling capabilities, and resources for recording and analyzing functional connectivity. Investigators describe how the resources they provide to the community will contribute to achieving the goals of the NIH BRAIN Initiative. Finally, in addition to celebrating the contributions of these BRAIN-funded investigators, the Mini-Symposium will illustrate the broader diversity of BRAIN Initiative investments in cutting-edge technologies and resources.

Published
2019

11. The NIH BRAIN Initiative: Integrating Neuroethics and Neuroscience

Author

Ramos, Khara M, Grady, Christine, Greely, Henry T, Chiong, Winston, Eberwine, James, Farahany, Nita A, Johnson, L Syd M, Hyman, Bradley T, Hyman, Steven E, Rommelfanger, Karen S, Serrano, Elba E, Churchill, James D, Gordon, Joshua A, and Koroshetz, Walter J

Subjects
Biological Psychology, Psychology, Rare Diseases, Brain Disorders, Neurosciences, Cancer, Brain Cancer, Neurological, Good Health and Well Being, Bioethics, Humans, National Institutes of Health (U.S.), Practice Guidelines as Topic, United States, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

The NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is focused on developing new tools and neurotechnologies to transform our understanding of the brain, and neuroethics is an essential component of this research effort. Coordination with other brain projects around the world will help maximize success.

Published
2019

12. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019

Author

Nichols, Emma, Steinmetz, Jaimie D, Vollset, Stein Emil, Fukutaki, Kai, Chalek, Julian, Abd-Allah, Foad, Abdoli, Amir, Abualhasan, Ahmed, Abu-Gharbieh, Eman, Akram, Tayyaba Tayyaba, Al Hamad, Hanadi, Alahdab, Fares, Alanezi, Fahad Mashhour, Alipour, Vahid, Almustanyir, Sami, Amu, Hubert, Ansari, Iman, Arabloo, Jalal, Ashraf, Tahira, Astell-Burt, Thomas, Ayano, Getinet, Ayuso-Mateos, Jose L, Baig, Atif Amin, Barnett, Anthony, Barrow, Amadou, Baune, Bernhard T, Béjot, Yannick, Bezabhe, Woldesellassie M Mequanint, Bezabih, Yihienew Mequanint, Bhagavathula, Akshaya Srikanth, Bhaskar, Sonu, Bhattacharyya, Krittika, Bijani, Ali, Biswas, Atanu, Bolla, Srinivasa Rao, Boloor, Archith, Brayne, Carol, Brenner, Hermann, Burkart, Katrin, Burns, Richard A, Cámera, Luis Alberto, Cao, Chao, Carvalho, Felix, Castro-de-Araujo, Luis F S, Catalá-López, Ferrán, Cerin, Ester, Chavan, Prachi P, Cherbuin, Nicolas, Chu, Dinh-Toi, Costa, Vera Marisa, Couto, Rosa A S, Dadras, Omid, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, De la Cruz-Góngora, Vanessa, Dhamnetiya, Deepak, Dias da Silva, Diana, Diaz, Daniel, Douiri, Abdel, Edvardsson, David, Ekholuenetale, Michael, El Sayed, Iman, El-Jaafary, Shaimaa I, Eskandari, Khalil, Eskandarieh, Sharareh, Esmaeilnejad, Saman, Fares, Jawad, Faro, Andre, Farooque, Umar, Feigin, Valery L, Feng, Xiaoqi, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Ferrara, Pietro, Filip, Irina, Fillit, Howard, Fischer, Florian, Gaidhane, Shilpa, Galluzzo, Lucia, Ghashghaee, Ahmad, Ghith, Nermin, Gialluisi, Alessandro, Gilani, Syed Amir, Glavan, Ionela-Roxana, Gnedovskaya, Elena V, Golechha, Mahaveer, Gupta, Rajeev, Gupta, Veer Bala, Gupta, Vivek Kumar, Haider, Mohammad Rifat, Hall, Brian J, Hamidi, Samer, Hanif, Asif, Hankey, Graeme J, Haque, Shafiul, Hartono, Risky Kusuma, Hasaballah, Ahmed I, Hasan, M Tasdik, Hassan, Amr, Hay, Simon I, Hayat, Khezar, Hegazy, Mohamed I, Heidari, Golnaz, Heidari-Soureshjani, Reza, Herteliu, Claudiu, Househ, Mowafa, Hussain, Rabia, Hwang, Bing-Fang, Iacoviello, Licia, Iavicoli, Ivo, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Irvani, Seyed Sina Naghibi, Iso, Hiroyasu, Iwagami, Masao, Jabbarinejad, Roxana, Jacob, Louis, Jain, Vardhmaan, Jayapal, Sathish Kumar, Jayawardena, Ranil, Jha, Ravi Prakash, Jonas, Jost B, Joseph, Nitin, Kalani, Rizwan, Kandel, Amit, Kandel, Himal, Karch, André, Kasa, Ayele Semachew, Kassie, Gizat M, Keshavarz, Pedram, Khan, Moien AB, Khatib, Mahalaqua Nazli, Khoja, Tawfik Ahmed Muthafer, Khubchandani, Jagdish, Kim, Min Seo, Kim, Yun Jin, Kisa, Adnan, Kisa, Sezer, Kivimäki, Mika, Koroshetz, Walter J, Koyanagi, Ai, Kumar, G Anil, Kumar, Manasi, Lak, Hassan Mehmood, Leonardi, Matilde, Li, Bingyu, Lim, Stephen S, Liu, Xuefeng, Liu, Yuewei, Logroscino, Giancarlo, Lorkowski, Stefan, Lucchetti, Giancarlo, Lutzky Saute, Ricardo, Magnani, Francesca Giulia, Malik, Ahmad Azam, Massano, João, Mehndiratta, Man Mohan, Menezes, Ritesh G, Meretoja, Atte, Mohajer, Bahram, Mohamed Ibrahim, Norlinah, Mohammad, Yousef, Mohammed, Arif, Mokdad, Ali H, Mondello, Stefania, Moni, Mohammad Ali Ali, Moniruzzaman, Md, Mossie, Tilahun Belete, Nagel, Gabriele, Naveed, Muhammad, Nayak, Vinod C, Neupane Kandel, Sandhya, Nguyen, Trang Huyen, Oancea, Bogdan, Otstavnov, Nikita, Otstavnov, Stanislav S, Owolabi, Mayowa O, Panda-Jonas, Songhomitra, Pashazadeh Kan, Fatemeh, Pasovic, Maja, Patel, Urvish K, Pathak, Mona, Peres, Mario F P, Perianayagam, Arokiasamy, Peterson, Carrie B, Phillips, Michael R, Pinheiro, Marina, Piradov, Michael A, Pond, Constance Dimity, Potashman, Michele H, Pottoo, Faheem Hyder, Prada, Sergio I, Radfar, Amir, Raggi, Alberto, Rahim, Fakher, Rahman, Mosiur, Ram, Pradhum, Ranasinghe, Priyanga, Rawaf, David Laith, Rawaf, Salman, Rezaei, Nima, Rezapour, Aziz, Robinson, Stephen R, Romoli, Michele, Roshandel, Gholamreza, Sahathevan, Ramesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Sathian, Brijesh, Sattin, Davide, Sawhney, Monika, Saylan, Mete, Schiavolin, Silvia, Seylani, Allen, Sha, Feng, Shaikh, Masood Ali, Shaji, KS, Shannawaz, Mohammed, Shetty, Jeevan K, Shigematsu, Mika, Shin, Jae Il, Shiri, Rahman, Silva, Diego Augusto Santos, Silva, João Pedro, Silva, Renata, Singh, Jasvinder A, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Smith, Amanda E, Soshnikov, Sergey, Spurlock, Emma Elizabeth, Stein, Dan J, Sun, Jing, Tabarés-Seisdedos, Rafael, Thakur, Bhaskar, Timalsina, Binod, Tovani-Palone, Marcos Roberto, Tran, Bach Xuan, Tsegaye, Gebiyaw Wudie, Valadan Tahbaz, Sahel, Valdez, Pascual R, Venketasubramanian, Narayanaswamy, Vlassov, Vasily, Vu, Giang Thu, Vu, Linh Gia, Wang, Yuan-Pang, Wimo, Anders, Winkler, Andrea Sylvia, Yadav, Lalit, Yahyazadeh Jabbari, Seyed Hossein, Yamagishi, Kazumasa, Yang, Lin, Yano, Yuichiro, Yonemoto, Naohiro, Yu, Chuanhua, Yunusa, Ismaeel, Zadey, Siddhesh, Zastrozhin, Mikhail Sergeevich, Zastrozhina, Anasthasia, Zhang, Zhi-Jiang, Murray, Christopher J L, and Vos, Theo

Published
2022
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13. Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting

Author

Walsh, Ryan R, Krismer, Florian, Galpern, Wendy R, Wenning, Gregor K, Low, Phillip A, Halliday, Glenda, Koroshetz, Walter J, Holton, Janice, Quinn, Niall P, Rascol, Olivier, Shaw, Leslie M, Eidelberg, David, Bower, Pam, Cummings, Jeffrey L, Abler, Victor, Biedenharn, Judy, Bitan, Gal, Brooks, David J, Brundin, Patrik, Fernandez, Hubert, Fortier, Philip, Freeman, Roy, Gasser, Thomas, Hewitt, Art, Höglinger, Günter U, Huentelman, Matt J, Jensen, Poul H, Jeromin, Andreas, Kang, Un Jung, Kaufmann, Horacio, Kellerman, Lawrence, Khurana, Vikram, Klockgether, Thomas, Kim, Woojin Scott, Langer, Carol, LeWitt, Peter, Masliah, Eliezer, Meissner, Wassilios, Melki, Ronald, Ostrowitzki, Susanne, Piantadosi, Steven, Poewe, Werner, Robertson, David, Roemer, Cyndi, Schenk, Dale, Schlossmacher, Michael, Schmahmann, Jeremy D, Seppi, Klaus, Shih, Lily, Siderowf, Andrew, Stebbins, Glenn T, Stefanova, Nadia, Tsuji, Shoji, Sutton, Sharon, and Zhang, Jing

Subjects
Rare Diseases, Humans, Multiple System Atrophy, Nevada, Patient Advocacy, Research Design, Clinical Sciences, Neurosciences, Cognitive Sciences, Neurology & Neurosurgery
Abstract

Multiple system atrophy (MSA) is a rare neurodegenerative disorder with substantial knowledge gaps despite recent gains in basic and clinical research. In order to make further advances, concerted international collaboration is vital. In 2014, an international meeting involving leaders in the field and MSA advocacy groups was convened in Las Vegas, Nevada, to identify critical research areas where consensus and progress was needed to improve understanding, diagnosis, and treatment of the disease. Eight topic areas were defined: pathogenesis, preclinical modeling, target identification, endophenotyping, clinical measures, imaging biomarkers, nonimaging biomarkers, treatments/trial designs, and patient advocacy. For each topic area, an expert served as a working group chair and each working group developed priority-ranked research recommendations with associated timelines and pathways to reach the intended goals. In this report, each groups' recommendations are provided.

Published
2018

16. Alzheimer's Disease–Related Dementias Summit 2016

Author

Corriveau, Roderick A, Koroshetz, Walter J, Gladman, Jordan T, Jeon, Sophia, Babcock, Debra, Bennett, David A, Carmichael, S Thomas, Dickinson, Susan L-J, Dickson, Dennis W, Emr, Marian, Fillit, Howard, Greenberg, Steven M, Hutton, Michael L, Knopman, David S, Manly, Jennifer J, Marder, Karen S, Moy, Claudia S, Phelps, Creighton H, Scott, Paul A, Seeley, William W, Sieber, Beth-Anne, Silverberg, Nina B, Sutherland, Margaret L, Taylor, Angela, Torborg, Christine L, Waddy, Salina P, Gubitz, Amelie K, and Holtzman, David M

Subjects
Acquired Cognitive Impairment, Vascular Cognitive Impairment/Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Dementia, Brain Disorders, Neurosciences, Alzheimer's Disease Related Dementias (ADRD), Aging, Alzheimer's Disease, Neurodegenerative, 2.1 Biological and endogenous factors, Aetiology, Neurological, Alzheimer Disease, Goals, Humans, Research, United States, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery
Abstract

Goal 1 of the National Plan to Address Alzheimer's Disease is to prevent and effectively treat Alzheimer disease and Alzheimer disease-related dementias by 2025. To help inform the research agenda toward achieving this goal, the NIH hosts periodic summits that set and refine relevant research priorities for the subsequent 5 to 10 years. This proceedings article summarizes the 2016 Alzheimer's Disease-Related Dementias Summit, including discussion of scientific progress, challenges, and opportunities in major areas of dementia research, including mixed-etiology dementias, Lewy body dementia, frontotemporal degeneration, vascular contributions to cognitive impairment and dementia, dementia disparities, and dementia nomenclature.

Published
2017

17. Translational Stroke Research

Author

Bosetti, Francesca, Koenig, James I, Ayata, Cenk, Back, Stephen A, Becker, Kyra, Broderick, Joseph P, Carmichael, S Thomas, Cho, Sunghee, Cipolla, Marilyn J, Corbett, Dale, Corriveau, Roderick A, Cramer, Steven C, Ferguson, Adam R, Finklestein, Seth P, Ford, Byron D, Furie, Karen L, Hemmen, Thomas M, Iadecola, Costantino, Jakeman, Lyn B, Janis, Scott, Jauch, Edward C, Johnston, Karen C, Kochanek, Patrick M, Kohn, Harold, Lo, Eng H, Lyden, Patrick D, Mallard, Carina, McCullough, Louise D, McGavern, Linda M, Meschia, James F, Moy, Claudia S, Perez-Pinzon, Miguel A, Ramadan, Ipolia, Savitz, Sean I, Schwamm, Lee H, Steinberg, Gary K, Stenzel-Poore, Mary P, Tymianski, Michael, Warach, Steven, Wechsler, Lawrence R, Zhang, John H, and Koroshetz, Walter

Subjects
Age Factors, Animals, Chronic Disease, Comorbidity, Disease Models, Animal, Humans, Recovery of Function, Research, Sex Factors, Stroke, Thrombectomy, Thrombolytic Therapy, Translational Research, Biomedical, animal model, biomarker, outcome, recovery, reperfusion, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurosciences, Neurology & Neurosurgery
Published
2017

18. Translational Stroke Research: Vision and Opportunities.

Author

Bosetti, Francesca, Koenig, James I, Ayata, Cenk, Back, Stephen A, Becker, Kyra, Broderick, Joseph P, Carmichael, S Thomas, Cho, Sunghee, Cipolla, Marilyn J, Corbett, Dale, Corriveau, Roderick A, Cramer, Steven C, Ferguson, Adam R, Finklestein, Seth P, Ford, Byron D, Furie, Karen L, Hemmen, Thomas M, Iadecola, Costantino, Jakeman, Lyn B, Janis, Scott, Jauch, Edward C, Johnston, Karen C, Kochanek, Patrick M, Kohn, Harold, Lo, Eng H, Lyden, Patrick D, Mallard, Carina, McCullough, Louise D, McGavern, Linda M, Meschia, James F, Moy, Claudia S, Perez-Pinzon, Miguel A, Ramadan, Ipolia, Savitz, Sean I, Schwamm, Lee H, Steinberg, Gary K, Stenzel-Poore, Mary P, Tymianski, Michael, Warach, Steven, Wechsler, Lawrence R, Zhang, John H, and Koroshetz, Walter

Subjects
Animals, Humans, Disease Models, Animal, Chronic Disease, Thrombolytic Therapy, Thrombectomy, Age Factors, Comorbidity, Sex Factors, Recovery of Function, Research, Stroke, Translational Medical Research, animal model, biomarker, outcome, recovery, reperfusion, Neurology & Neurosurgery, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurosciences
Published
2017

19. Launching Effectiveness Research to Guide Practice in Neurosurgery: A National Institute Neurological Disorders and Stroke Workshop Report

Author

Walicke, Patricia, Abosch, Aviva, Asher, Anthony, Barker, Fred G, Ghogawala, Zoher, Harbaugh, Robert, Jehi, Lara, Kestle, John, Koroshetz, Walter, Little, Roderick, Rubin, Donald, Valadka, Alex, Wisniewski, Stephen, and Chiocca, E Antonio

Subjects
Clinical Trials and Supportive Activities, Neurosciences, Comparative Effectiveness Research, Clinical Research, Academies and Institutes, Biomedical Research, Clinical Trials as Topic, Guidelines as Topic, Humans, Neurosurgery, Neurosurgical Procedures, Research Design, Workshop Participants, Clinical trials, Effectiveness research, Equipoise, Randomized controlled trial, Registry, Clinical Sciences, Neurology & Neurosurgery
Abstract

This workshop addressed challenges of clinical research in neurosurgery. Randomized controlled clinical trials (RCTs) have high internal validity, but often insufficiently generalize to real-world practice. Observational studies are inclusive but often lack sufficient rigor. The workshop considered possible solutions, such as (1) statistical methods for demonstrating causality using observational data; (2) characteristics required of a registry supporting effectiveness research; (3) trial designs combining advantages of observational studies and RCTs; and (4) equipoise, an identified challenge for RCTs. In the future, advances in information technology potentially could lead to creation of a massive database where clinical data from all neurosurgeons are integrated and analyzed, ending the separation of clinical research and practice and leading to a new "science of practice."

Published
2017

22. "Small Blood Vessels: Big Health Problems?": Scientific Recommendations of the National Institutes of Health Workshop.

Author

Bosetti, Francesca, Galis, Zorina S, Bynoe, Margaret S, Charette, Marc, Cipolla, Marilyn J, Del Zoppo, Gregory J, Gould, Douglas, Hatsukami, Thomas S, Jones, Teresa LZ, Koenig, James I, Lutty, Gerard A, Maric-Bilkan, Christine, Stevens, Troy, Tolunay, H Eser, Koroshetz, Walter, and “Small Blood Vessels: Big Health Problems” Workshop Participants

Subjects
“Small Blood Vessels: Big Health Problems” Workshop Participants, Microcirculation, Capillaries, Humans, Cardiovascular Diseases, Coronary Circulation, National Institutes of Health (U.S.), Health, United States, Practice Guidelines as Topic, endothelium, hypertension, imaging, ischemia, microcirculation, remodeling, Cardiorespiratory Medicine and Haematology
Published
2016

23. Worldwide initiatives to advance brain research

Author

Grillner, Sten, Ip, Nancy, Koch, Christof, Koroshetz, Walter, Okano, Hideyuki, Polachek, Miri, Poo, Mu-ming, and Sejnowski, Terrence J

Subjects
Biological Psychology, Psychology, Neurological, Mental health, Biomedical Research, Brain, Brain Diseases, Global Health, Humans, Neurosciences, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

To highlight worldwide efforts to fund neuroscience research and address the growing threat of brain disorders, Nature Neuroscience asked leaders of six global brain initiatives to write about their programs.

Published
2016

24. Field Assessment Stroke Triage for Emergency Destination: A Simple and Accurate Prehospital Scale to Detect Large Vessel Occlusion Strokes.

Author

Lima, Fabricio, Silva, Gisele, Furie, Karen, Frankel, Michael, Lev, Michael, Camargo, Érica, Haussen, Diogo, Singhal, Aneesh, Koroshetz, Walter, Smith, Wade, and Nogueira, Raul

Subjects
cerebrovascular occlusion, scale, stroke, acute, prehospital emergency care, triage, Aged, Aged, 80 and over, Arterial Occlusive Diseases, Brain, Brain Ischemia, Computed Tomography Angiography, Emergency Medical Services, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Sensitivity and Specificity, Severity of Illness Index, Stroke, Triage
Abstract

BACKGROUND AND PURPOSE: Patients with large vessel occlusion strokes (LVOS) may be better served by direct transfer to endovascular capable centers avoiding hazardous delays between primary and comprehensive stroke centers. However, accurate stroke field triage remains challenging. We aimed to develop a simple field scale to identify LVOS. METHODS: The Field Assessment Stroke Triage for Emergency Destination (FAST-ED) scale was based on items of the National Institutes of Health Stroke Scale (NIHSS) with higher predictive value for LVOS and tested in the Screening Technology and Outcomes Project in Stroke (STOPStroke) cohort, in which patients underwent computed tomographic angiography within the first 24 hours of stroke onset. LVOS were defined by total occlusions involving the intracranial internal carotid artery, middle cerebral artery-M1, middle cerebral artery-2, or basilar arteries. Patients with partial, bihemispheric, and anterior+posterior circulation occlusions were excluded. Receiver operating characteristic curve, sensitivity, specificity, positive predictive value, and negative predictive value of FAST-ED were compared with the NIHSS, Rapid Arterial Occlusion Evaluation (RACE) scale, and Cincinnati Prehospital Stroke Severity (CPSS) scale. RESULTS: LVO was detected in 240 of the 727 qualifying patients (33%). FAST-ED had comparable accuracy to predict LVO to the NIHSS and higher accuracy than RACE and CPSS (area under the receiver operating characteristic curve: FAST-ED=0.81 as reference; NIHSS=0.80, P=0.28; RACE=0.77, P=0.02; and CPSS=0.75, P=0.002). A FAST-ED ≥4 had sensitivity of 0.60, specificity of 0.89, positive predictive value of 0.72, and negative predictive value of 0.82 versus RACE ≥5 of 0.55, 0.87, 0.68, and 0.79, and CPSS ≥2 of 0.56, 0.85, 0.65, and 0.78, respectively. CONCLUSIONS: FAST-ED is a simple scale that if successfully validated in the field, it may be used by medical emergency professionals to identify LVOS in the prehospital setting enabling rapid triage of patients.

Published
2016

25. Initiating Long Covid RECOVERy.

Author

Marrazzo, Jeanne, Gibbons, Gary H., and Koroshetz, Walter

Subjects
POST-acute COVID-19 syndrome, SUFFERING
Abstract

The NIH's RECOVER Initiative aims to ease the suffering of those living with Long Covid. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Validity of Acute Stroke Lesion Volume Estimation by Diffusion-Weighted Imaging–Alberta Stroke Program Early Computed Tomographic Score Depends on Lesion Location in 496 Patients With Middle Cerebral Artery Stroke

Author

Schröder, Julian, Cheng, Bastian, Ebinger, Martin, Köhrmann, Martin, Wu, Ona, Kang, Dong-Wha, Liebeskind, David S, Tourdias, Thomas, Singer, Oliver C, Christensen, Soren, Campbell, Bruce, Luby, Marie, Warach, Steven, Fiehler, Jens, Fiebach, Jochen B, Gerloff, Christian, Thomalla, Götz, Albers, Gregory, Davis, Stephen, Donnan, Geoffrey, Fisher, Marc, Furlan, Anthony, Grotta, James, Hacke, Werner, Kidwell, Chelsea, Koroshetz, Walter, Lees, Kennedy R, Lev, Michael, Sorensen, A Gregory, Thijs, Vincent, Wardlaw, Joanna, Wintermark, Max, Hao, Qing, Kim, Jong S, Breuer, Lorenz, Treszl, Andras, Forkert, Nils D, Galinovic, Ivana, Rosenkranz, Michael, Engelhorn, Tobias, Endres, Matthias, and Dousset, Vincent

Subjects
Neurosciences, Stroke, Clinical Research, Brain Disorders, Biomedical Imaging, Aged, Diffusion Magnetic Resonance Imaging, Female, Humans, Infarction, Middle Cerebral Artery, Male, Middle Aged, Tomography, X-Ray Computed, brain ischemia, diffusion magnetic resonance imaging, magnetic resonance imaging, middle cerebral artery, neuroimaging, severity of illness index, stroke, STIR and VISTA Imaging Investigators, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeAlberta Stroke Program Early Computed Tomographic Score (ASPECTS) has been used to estimate diffusion-weighted imaging (DWI) lesion volume in acute stroke. We aimed to assess correlations of DWI-ASPECTS with lesion volume in different middle cerebral artery (MCA) subregions and reproduce existing ASPECTS thresholds of a malignant profile defined by lesion volume ≥100 mL.MethodsWe analyzed data of patients with MCA stroke from a prospective observational study of DWI and fluid-attenuated inversion recovery in acute stroke. DWI-ASPECTS and lesion volume were calculated. The population was divided into subgroups based on lesion localization (superficial MCA territory, deep MCA territory, or both). Correlation of ASPECTS and infarct volume was calculated, and receiver-operating characteristics curve analysis was performed to identify the optimal ASPECTS threshold for ≥100-mL lesion volume.ResultsA total of 496 patients were included. There was a significant negative correlation between ASPECTS and DWI lesion volume (r=-0.78; P

Published
2014

28. Recommendations of the Alzheimer's Disease–Related Dementias Conference

Author

Montine, Thomas J, Koroshetz, Walter J, Babcock, Debra, Dickson, Dennis W, Galpern, Wendy R, Glymour, M Maria, Greenberg, Steven M, Hutton, Michael L, Knopman, David S, Kuzmichev, Andrey N, Manly, Jennifer J, Marder, Karen S, Miller, Bruce L, Phelps, Creighton H, Seeley, William W, Sieber, Beth-Anne, Silverberg, Nina B, Sutherland, Margaret, Torborg, Christine L, Waddy, Salina P, Zlokovic, Berislav V, and Corriveau, Roderick A

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Acquired Cognitive Impairment, Alzheimer's Disease Related Dementias (ADRD), Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Dementia, Aging, Alzheimer's Disease, Brain Disorders, Neurodegenerative, Neurological, Alzheimer Disease, Humans, Research, United States, ADRD 2013 Conference Organizing Committee, Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences
Abstract

The National Alzheimer's Project Act, signed into law in 2011, mandates a National Plan to Address Alzheimer's Disease that is updated annually. In the Plan, the term Alzheimer disease includes not only Alzheimer disease (AD) proper, but also several specified related dementias, namely, frontotemporal, Lewy body, vascular, and mixed dementia. In response to a specific action item in the 2012 National Plan, the National Institute of Neurological Disorders and Stroke, in collaboration with the National Institute on Aging, convened panels of experts and conducted a 2-day public conference to develop research priorities and timelines for addressing Alzheimer disease-related dementias (ADRD) in 5 topic areas: multiple etiology dementias, health disparities, Lewy body dementias including dementia with Lewy bodies and Parkinson disease dementia, frontotemporal dementia and related tauopathies, and vascular contributions to ADRD. By design, the product was up to 8 prioritized research recommendations in each topic area including estimated timelines from when work on a recommendation is started to completion or to full implementation of an ongoing activity, and recognition of shared research themes across recommendations. These included increased education and training of both researchers and health care professionals, addressing health disparities, fundamental neurobiology research, advanced diagnostics, collaborative biosample repositories, and a focus on developing effective interventions to prevent or treat ADRD by the year 2025 as targeted by the National Plan.

Published
2014

29. The conception of the ABCD study: From substance use to a broad NIH collaboration

Author

Volkow, Nora D., Koob, George F., Croyle, Robert T., Bianchi, Diana W., Gordon, Joshua A., Koroshetz, Walter J., Pérez-Stable, Eliseo J., Riley, William T., Bloch, Michele H., Conway, Kevin, Deeds, Bethany G., Dowling, Gayathri J., Grant, Steven, Howlett, Katia D., Matochik, John A., Morgan, Glen D., Murray, Margaret M., Noronha, Antonio, Spong, Catherine Y., Wargo, Eric M., Warren, Kenneth R., and Weiss, Susan R.B.

Published
2018
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30. Implementation Research to Address the United States Health Disadvantage: Report of a National Heart, Lung, and Blood Institute Workshop

Author

Engelgau, Michael M., Narayan, K.M. Venkat, Ezzati, Majid, Salicrup, Luis A., Belis, Deshiree, Aron, Laudan Y., Beaglehole, Robert, Beaudet, Alain, Briss, Peter A., Chambers, David A., Devaux, Marion, Fiscella, Kevin, Gottlieb, Michael, Hakkinen, Unto, Henderson, Rain, Hennis, Anselm J., Hochman, Judith S., Jan, Stephen, Koroshetz, Walter J., Mackenbach, Johan P., Marmot, M.G., Martikainen, Pekka, McClellan, Mark, Meyers, David, Parsons, Polly E., Rehnberg, Clas, Sanghavi, Darshak, Sidney, Stephen, Siega-Riz, Anna Maria, Straus, Sharon, Woolf, Steven H., Constant, Stephanie, Creazzo, Tony L., de Jesus, Janet M., Gavini, Nara, Lerner, Norma B., Mishoe, Helena O., Nelson, Cheryl, Peprah, Emmanuel, Punturieri, Antonello, Sampson, Uchechukwu, Tracy, Rachael L., and Mensah, George A.

Published
2018
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31. Good Outcome Rate of 35% in IV-tPA–Treated Patients With Computed Tomography Angiography Confirmed Severe Anterior Circulation Occlusive Stroke

Author

González, R Gilberto, Furie, Karen L, Goldmacher, Gregory V, Smith, Wade S, Kamalian, Shervin, Payabvash, Seyedmehdi, Harris, Gordon J, Halpern, Elkan F, Koroshetz, Walter J, Camargo, Erica CS, Dillon, William P, and Lev, Michael H

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Biomedical Imaging, Neurosciences, Stroke, Brain Disorders, Clinical Research, Aged, Brain Infarction, Cerebral Angiography, Female, Fibrinolytic Agents, Humans, Infusions, Intravenous, Male, Middle Aged, Prospective Studies, Thrombolytic Therapy, Tissue Plasminogen Activator, Tomography, X-Ray Computed, Treatment Outcome, computed tomography angiography, ischemic stroke, thrombolysis, tissue plasminogen activator, treatment outcome, Cardiorespiratory Medicine and Haematology, Neurology & Neurosurgery, Clinical sciences, Allied health and rehabilitation science
Abstract

Background and purposeTo determine the effect of intravenous tissue plasminogen activator (IV-tPA) on outcomes in patients with severe major anterior circulation ischemic stroke.MethodsProspectively, 649 patients with acute stroke had admission National Institutes of Health stroke scale (NIHSS) scores, noncontrast computed tomography (CT), CT angiography (CTA), and 6-month outcome assessed using modified Rankin scale. IV-tPA treatment decisions were made before CTA, at the time of noncontrast CT scanning, as per routine clinical protocol. Severe symptoms were defined as NIHSS>10. Poor outcome was defined as modified Rankin scale >2. Major occlusions were identified on CTA. Univariate and multivariate stepwise-forward logistic regression analyses of the full cohort were performed.ResultsOf 649 patients, 188 (29%) patients presented with NIHSS>10, and 64 out of 188 (34%) patients received IV-tPA. Admission NIHSS, large artery occlusion, and IV-tPA all independently predicted good outcomes; however, a significant interaction existed between IV-tPA and occlusion (P10 with anterior circulation occlusion, twice the percentage had good outcomes if they received IV-tPA (17 out of 49 patients, 35%) than if they did not (13 out of 77 patients, 17%; P=0.031). The number needed to treat was 7 (95% confidence interval, 3-60).ConclusionsIV-tPA treatment resulted in significantly better outcomes in patients with severely symptomatic stroke with major anterior circulation occlusions. The 35% good outcome rate was similar to rates found in endovascular therapy trials. Vascular imaging may help in patient selection and stratification for trials of IV-thrombolytic and endovascular therapies.

Published
2013

33. A call for transparent reporting to optimize the predictive value of preclinical research

Author

Landis, Story C, Amara, Susan G, Asadullah, Khusru, Austin, Chris P, Blumenstein, Robi, Bradley, Eileen W, Crystal, Ronald G, Darnell, Robert B, Ferrante, Robert J, Fillit, Howard, Finkelstein, Robert, Fisher, Marc, Gendelman, Howard E, Golub, Robert M, Goudreau, John L, Gross, Robert A, Gubitz, Amelie K, Hesterlee, Sharon E, Howells, David W, Huguenard, John, Kelner, Katrina, Koroshetz, Walter, Krainc, Dimitri, Lazic, Stanley E, Levine, Michael S, Macleod, Malcolm R, McCall, John M, Moxley III, Richard T, Narasimhan, Kalyani, Noble, Linda J, Perrin, Steve, Porter, John D, Steward, Oswald, Unger, Ellis, Utz, Ursula, and Silberberg, Shai D

Subjects
Accounting, Auditing and Accountability, Biomedical and Clinical Sciences, Commerce, Management, Tourism and Services, Animals, Publishing, Random Allocation, Research Design, Sample Size, Statistics as Topic, General Science & Technology
Abstract

The US National Institute of Neurological Disorders and Stroke convened major stakeholders in June 2012 to discuss how to improve the methodological reporting of animal studies in grant applications and publications. The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were randomized, whether investigators were blind to the treatment, and the handling of data. We recognize that achieving a meaningful improvement in the quality of reporting will require a concerted effort by investigators, reviewers, funding agencies and journal editors. Requiring better reporting of animal studies will raise awareness of the importance of rigorous study design to accelerate scientific progress.

Published
2012

34. Improved outcome prediction using CT angiography in addition to standard ischemic stroke assessment: results from the STOPStroke study.

Author

González, R Gilberto, Lev, Michael H, Goldmacher, Gregory V, Smith, Wade S, Payabvash, Seyedmehdi, Harris, Gordon J, Halpern, Elkan F, Koroshetz, Walter J, Camargo, Erica CS, Dillon, William P, and Furie, Karen L

Subjects
Humans, Brain Ischemia, Tomography, X-Ray Computed, Cerebral Angiography, Aged, Aged, 80 and over, Middle Aged, Female, Male, Stroke, Tomography, X-Ray Computed, and over, General Science & Technology
Abstract

PurposeTo improve ischemic stroke outcome prediction using imaging information from a prospective cohort who received admission CT angiography (CTA).MethodsIn a prospectively designed study, 649 stroke patients diagnosed with acute ischemic stroke had admission NIH stroke scale scores, noncontrast CT (NCCT), CTA, and 6-month outcome assessed using the modified Rankin scale (mRS) scores. Poor outcome was defined as mRS>2. Strokes were classified as "major" by the (1) Alberta Stroke Program Early CT Score (ASPECTS+) if NCCT ASPECTS was ≤7; (2) Boston Acute Stroke Imaging Scale (BASIS+) if they were ASPECTS+ or CTA showed occlusion of the distal internal carotid, proximal middle cerebral, or basilar arteries; and (3) NIHSS for scores >10.ResultsOf 649 patients, 253 (39.0%) had poor outcomes. NIHSS, BASIS, and age, but not ASPECTS, were independent predictors of outcome. BASIS and NIHSS had similar sensitivities, both superior to ASPECTS (p10/BASIS+ had poor outcomes, versus 21.5% (77/358) with NIHSS≤10/BASIS- (p10/BASIS+ compared to patients who are NIHSS≤10/BASIS-; the odds ratio is 5.4 (95% CI: 3.5 to 8.5) when compared to patients who are only NIHSS>10 or BASIS+.ConclusionsBASIS and NIHSS are independent outcome predictors. Their combination is stronger than either instrument alone in predicting outcomes. The findings suggest that CTA is a significant clinical tool in routine acute stroke assessment.

Published
2012

35. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.

Author

McKhann, Guy M, Knopman, David S, Chertkow, Howard, Hyman, Bradley T, Jack, Clifford R, Kawas, Claudia H, Klunk, William E, Koroshetz, Walter J, Manly, Jennifer J, Mayeux, Richard, Mohs, Richard C, Morris, John C, Rossor, Martin N, Scheltens, Philip, Carrillo, Maria C, Thies, Bill, Weintraub, Sandra, and Phelps, Creighton H

Subjects
Humans, Alzheimer Disease, Disease Progression, Diagnosis, Differential, Diagnostic Imaging, Societies, Medical, United States, Practice Guidelines as Topic, National Institute on Aging (U.S.), Biomarkers, Alzheimer's disease, Dementia, Diagnosis, Magnetic resonance brain imaging, Positron emission tomography, Cerebrospinal fluid, Differential, Societies, Medical, National Institute on Aging, Geriatrics, Neurosciences, Clinical Sciences
Abstract

The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of revising the 1984 criteria for Alzheimer's disease (AD) dementia. The workgroup sought to ensure that the revised criteria would be flexible enough to be used by both general healthcare providers without access to neuropsychological testing, advanced imaging, and cerebrospinal fluid measures, and specialized investigators involved in research or in clinical trial studies who would have these tools available. We present criteria for all-cause dementia and for AD dementia. We retained the general framework of probable AD dementia from the 1984 criteria. On the basis of the past 27 years of experience, we made several changes in the clinical criteria for the diagnosis. We also retained the term possible AD dementia, but redefined it in a manner more focused than before. Biomarker evidence was also integrated into the diagnostic formulations for probable and possible AD dementia for use in research settings. The core clinical criteria for AD dementia will continue to be the cornerstone of the diagnosis in clinical practice, but biomarker evidence is expected to enhance the pathophysiological specificity of the diagnosis of AD dementia. Much work lies ahead for validating the biomarker diagnosis of AD dementia.

Published
2011

37. Meeting Report: Consensus Statement—Parkinson’s Disease and the Environment: Collaborative on Health and the Environment and Parkinson’s Action Network (CHE PAN) Conference 26–28 June 2007

Author

Bronstein, Jeff, Carvey, Paul, Chen, Honglei, Cory-Slechta, Deborah, DiMonte, Donato, Duda, John, English, Paul, Goldman, Samuel, Grate, Stephen, Hansen, Johnni, Hoppin, Jane, Jewell, Sarah, Kamel, Freya, Koroshetz, Walter, Langston, James W, Logroscino, Giancarlo, Nelson, Lorene, Ravina, Bernard, Rocca, Walter, Ross, George W, Schettler, Ted, Schwarzschild, Michael, Scott, Bill, Seegal, Richard, Singleton, Andrew, Steenland, Kyle, Tanner, Caroline M, Van Den Eeden, Stephen, and Weisskopf, Marc

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Brain Disorders, Neurodegenerative, Parkinson's Disease, Prevention, Genetics, Aging, Neurosciences, Aetiology, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, 2.3 Psychological, social and economic factors, Neurological, Cooperative Behavior, Environment, Environmental Pollutants, Humans, Parkinson Disease, Research, cholesterol, coffee, dairy products, diet, dopamine, fatty acids, metals, nonsteroidal anti-inflammatory drugs, Parkinson's disease, pesticides, polychlorinated biphenyls, smoking, statins, urate, Parkinson’s disease, Environmental Sciences, Medical and Health Sciences, Toxicology, Biomedical and clinical sciences, Environmental sciences, Health sciences
Abstract

BackgroundParkinson's disease (PD) is the second most common neurodegenerative disorder. People with PD, their families, scientists, health care providers, and the general public are increasingly interested in identifying environmental contributors to PD risk.MethodsIn June 2007, a multidisciplinary group of experts gathered in Sunnyvale, California, USA, to assess what is known about the contribution of environmental factors to PD.ResultsWe describe the conclusions around which they came to consensus with respect to environmental contributors to PD risk. We conclude with a brief summary of research needs.ConclusionsPD is a complex disorder, and multiple different pathogenic pathways and mechanisms can ultimately lead to PD. Within the individual there are many determinants of PD risk, and within populations, the causes of PD are heterogeneous. Although rare recognized genetic mutations are sufficient to cause PD, these account for < 10% of PD in the U.S. population, and incomplete penetrance suggests that environmental factors may be involved. Indeed, interplay among environmental factors and genetic makeup likely influences the risk of developing PD. There is a need for further understanding of how risk factors interact, and studying PD is likely to increase understanding of other neurodegenerative disorders.

Published
2009

38. Huntington’s Disease

Author

Burke, Tom, Doherty, Colin P., Koroshetz, Walter, Pender, Niall, Hardiman, Orla, editor, Doherty, Colin P., editor, Elamin, Marwa, editor, and Bede, Peter, editor

Published
2016
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39. The case for modality-specific outcome measures in clinical trials of stroke recovery-promoting agents.

Author

Cramer, Steven C, Koroshetz, Walter J, and Finklestein, Seth P

Subjects
Humans, Neuroprotective Agents, Disability Evaluation, Thrombolytic Therapy, Selection Bias, Recovery of Function, Patient Selection, Quality of Life, Outcome Assessment (Health Care), Clinical Trials as Topic, Stroke, clinical trials, outcome measures, stroke recovery, Outcome Assessment, Clinical Sciences, Cardiorespiratory Medicine and Haematology, Neurosciences, Neurology & Neurosurgery
Abstract

Clinical trials for acute stroke treatments have often used composite clinical rating scales as primary outcome measures of treatment efficacy. Recent preclinical and clinical studies highlight the opportunity to administer treatments in the subacute and chronic phase of stroke to promote neurological recovery. Because different neurological deficits recover to different extents at different rates after stroke, putative stroke recovery-promoting treatments may exert differential effects on various functional aspects of stroke recovery. For this reason, we propose that the use of modality-specific outcome measures may be best suited as primary end points in clinical trials of stroke recovery-promoting agents. The use of such end points may result in a more selective labeling of stroke recovery treatments.

Published
2007

40. Beyond the symptom : the biology of fatigue

Author

Raizen, David M., Mullington, Janet, Anaclet, Christelle, Clarke, Gerard, Critchley, Hugo, Dantzer, Robert, Davis, Ronald, Drew, Kelly L., Fessel, Josh, Fuller, Patrick M., Gibson, Erin M., Harrington, Mary, Lipkin, W. Ian, Klerman, Elizabeth B., Klimas, Nancy, Komaroff, Anthony L., Koroshetz, Walter, Krupp, Lauren, Kuppuswamy, Anna, Lasselin, Julie, Lewis, Laura D., Magistretti, Pierre J., Matos, Heidi Y., Miaskowski, Christine, Miller, Andrew H., Nath, Avindra, Nedergaard, Maiken, Opp, Mark R., Ritchie, Marylyn D., Rogulja, Dragana, Rolls, Asya, Salamone, John D., Saper, Clifford, Whittemore, Vicky, Wylie, Glenn, Younger, Jarred, Zee, Phyllis C., Heller, H. Craig, Raizen, David M., Mullington, Janet, Anaclet, Christelle, Clarke, Gerard, Critchley, Hugo, Dantzer, Robert, Davis, Ronald, Drew, Kelly L., Fessel, Josh, Fuller, Patrick M., Gibson, Erin M., Harrington, Mary, Lipkin, W. Ian, Klerman, Elizabeth B., Klimas, Nancy, Komaroff, Anthony L., Koroshetz, Walter, Krupp, Lauren, Kuppuswamy, Anna, Lasselin, Julie, Lewis, Laura D., Magistretti, Pierre J., Matos, Heidi Y., Miaskowski, Christine, Miller, Andrew H., Nath, Avindra, Nedergaard, Maiken, Opp, Mark R., Ritchie, Marylyn D., Rogulja, Dragana, Rolls, Asya, Salamone, John D., Saper, Clifford, Whittemore, Vicky, Wylie, Glenn, Younger, Jarred, Zee, Phyllis C., and Heller, H. Craig

Abstract

A workshop titled “Beyond the Symptom: The Biology of Fatigue” was held virtually September 27–28, 2021. It was jointly organized by the Sleep Research Society and the Neurobiology of Fatigue Working Group of the NIH Blueprint Neuroscience Research Program. For access to the presentations and video recordings, see: https://neuroscienceblueprint.nih.gov/about/event/beyond-symptom-biology-fatigue. The goals of this workshop were to bring together clinicians and scientists who use a variety of research approaches to understand fatigue in multiple conditions and to identify key gaps in our understanding of the biology of fatigue. This workshop summary distills key issues discussed in this workshop and provides a list of promising directions for future research on this topic. We do not attempt to provide a comprehensive review of the state of our understanding of fatigue, nor to provide a comprehensive reprise of the many excellent presentations. Rather, our goal is to highlight key advances and to focus on questions and future approaches to answering them.

Published
2023
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42. Basic science: Bedrock of progress

Author

Collins, Francis S., Anderson, James M., Austin, Christopher P., Battey, James F., Birnbaum, Linda S., Briggs, Josephine P., Clayton, Janine A., Cuthbert, Bruce, Eisinger, Robert W., Fauci, Anthony S., Gallin, John I., Gibbons, Gary H., Glass, Roger I., Gottesman, Michael M., Gray, Patricia A., Green, Eric D., Greider, Franziska B., Hodes, Richard, Hudson, Kathy L., Humphreys, Betsy, Katz, Stephen I., Koob, George F., Koroshetz, Walter J., Lauer, Michael S., Lorsch, Jon R., Lowy, Douglas R., McGowan, John J., Murray, David M., Nakamura, Richard, Norris, Andrea, Perez-Stable, Eliseo J., Pettigrew, Roderic I., Riley, William T., Rodgers, Griffin P., Sieving, Paul A., Somerman, Martha J., Spong, Catherine Y., Tabak, Lawrence A., Volkow, Nora D., and Wilder, Elizabeth L.

Published
2016

46. Causes of Ischemic Stroke

Author

Silva, Gisele S., Koroshetz, Walter J., González, R. Gilberto, Schwamm, Lee H., González, R. Gilberto, editor, Hirsch, Joshua A., editor, Lev, Michael H., editor, Schaefer, Pamela W., editor, and Schwamm, Lee H., editor

Published
2011
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47. Clinical Management of Acute Stroke

Author

Rost, Natalia S., Koroshetz, Walter J., González, R. Gilberto, Schwamm, Lee H., González, R. Gilberto, editor, Hirsch, Joshua A., editor, Lev, Michael H., editor, Schaefer, Pamela W., editor, and Schwamm, Lee H., editor

Published
2011
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50. Hemorrhagic Stroke

Author

Oliveira-Filho, Jamary, Koroshetz, Walter J., O’Donnell, John M., editor, and Nácul, Flávio E., editor

Published
2010
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