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2. Comparative analysis of combined spectral and optical tomography methods for detection of skin and lung cancers.

Author

Zakharov VP, Bratchenko IA, Artemyev DN, Myakinin OO, Kornilin DV, Kozlov SV, and Moryatov AA

Subjects
Adult, Aged, Female, Humans, Lung pathology, Male, Middle Aged, Scattering, Radiation, Sensitivity and Specificity, Skin pathology, Image Interpretation, Computer-Assisted methods, Lung Neoplasms diagnosis, Skin Neoplasms diagnosis, Spectrum Analysis, Raman methods, Tomography, Optical Coherence methods
Abstract

Malignant skin tumors of different types were studied in vivo using optical coherence tomography (OCT), backscattering (BS), and Raman spectroscopy (RS). A multimodal method is proposed for early cancer detection based on complex analysis of OCT images by their relative alteration of scattered-radiation spectral intensities between malignant and healthy tissues. An increase in average accuracy of diagnosis was observed for a variety of cancer types (9% sensitivity, 8% specificity) by a multimodal RS-BS-OCT system in comparison with any of the three methods used separately. The proposed approach equalizes the processing rates for all methods and allows for simultaneous imaging and classification of tumors., (© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE))

Published
2015
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