Search

Your search keyword '"Kornfeld, Opher S."' showing total 15 results
Start Over Author "Kornfeld, Opher S."
15 results on '"Kornfeld, Opher S."'

1. Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury

Author

Kayagaki, Nobuhiko, Stowe, Irma B., Alegre, Kamela, Deshpande, Ishan, Wu, Shuang, Lin, Zhonghua, Kornfeld, Opher S., Lee, Bettina L., Zhang, Juan, Liu, John, Suto, Eric, Lee, Wyne P., Schneider, Kellen, Lin, WeiYu, Seshasayee, Dhaya, Bhangale, Tushar, Chalouni, Cecile, Johnson, Matthew C., Joshi, Prajakta, Mossemann, Jan, Zhao, Sarah, Ali, Danish, Goldenberg, Neil M., Sayed, Blayne A., Steinberg, Benjamin E., Newton, Kim, Webster, Joshua D., Kelly, Ryan L., and Dixit, Vishva M.

Published
2023
Full Text
View/download PDF

3. NINJ1 mediates plasma membrane rupture during lytic cell death

Author

Kayagaki, Nobuhiko, Kornfeld, Opher S., Lee, Bettina L., Stowe, Irma B., O’Rourke, Karen, Li, Qingling, Sandoval, Wendy, Yan, Donghong, Kang, Jing, Xu, Min, Zhang, Juan, Lee, Wyne P., McKenzie, Brent S., Ulas, Gözde, Payandeh, Jian, Roose-Girma, Merone, Modrusan, Zora, Reja, Rohit, Sagolla, Meredith, Webster, Joshua D., Cho, Vicky, Andrews, T. Daniel, Morris, Lucy X., Miosge, Lisa A., Goodnow, Christopher C., Bertram, Edward M., and Dixit, Vishva M.

Published
2021
Full Text
View/download PDF

6. Correcting mitochondrial fusion by manipulating mitofusin conformations

Author

Franco, Antonietta, Kitsis, Richard N., Fleischer, Julie A., Gavathiotis, Evripidis, Kornfeld, Opher S., Gong, Guohua, Biris, Nikolaos, Benz, Ann, Qvit, Nir, Donnelly, Sara K., Chen, Yun, Mennerick, Steven, Hodgson, Louis, Mochly-Rosen, Daria, and Dorn II, Gerald W.

Subjects
Cellular proteins -- Physiological aspects -- Genetic aspects, Gene mutation -- Research, Cytological research, Mitochondria -- Physiological aspects -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Mitochondria are dynamic organelles that exchange contents and undergo remodelling during cyclic fusion and fission. Genetic mutations in MFN2 (the gene encoding mitofusin 2) interrupt mitochondrial fusion and cause the untreatable neurodegenerative condition Charcot-Marie-Tooth disease type 2A (CMT2A). It has not yet been possible to directly modulate mitochondrial fusion, in part because the structural basis of mitofusin function is not completely understood. Here we show that mitofusins adopt either a fusion-constrained or a fusion-permissive molecular conformation, directed by specific intramolecular binding interactions, and demonstrate that mitofusin-dependent mitochondrial fusion can be regulated in mouse cells by targeting these conformational transitions. On the basis of this model, we engineered a cell-permeant minipeptide to destabilize the fusion-constrained conformation of mitofusin and promote the fusion-permissive conformation, reversing mitochondrial abnormalities in cultured fibroblasts and neurons that harbour CMT2A-associated genetic defects. The relationship between the conformational plasticity of mitofusin 2 and mitochondrial dynamism reveals a central mechanism that regulates mitochondrial fusion, the manipulation of which can correct mitochondrial pathology triggered by defective or imbalanced mitochondrial dynamics., Author(s): Antonietta Franco [1]; Richard N. Kitsis [2]; Julie A. Fleischer [1]; Evripidis Gavathiotis [3]; Opher S. Kornfeld [4]; Guohua Gong [1]; Nikolaos Biris [3]; Ann Benz [5]; Nir Qvit [...]

Published
2016
Full Text
View/download PDF

7. Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection

Author

Bjanes, Elisabet, primary, Sillas, Reyna Garcia, additional, Matsuda, Rina, additional, Demarco, Benjamin, additional, Fettrelet, Timothée, additional, DeLaney, Alexandra A., additional, Kornfeld, Opher S., additional, Lee, Bettina L., additional, Rodríguez López, Eric M., additional, Grubaugh, Daniel, additional, Wynosky-Dolfi, Meghan A., additional, Philip, Naomi H., additional, Krespan, Elise, additional, Tovar, Dorothy, additional, Joannas, Leonel, additional, Beiting, Daniel P., additional, Henao-Mejia, Jorge, additional, Schaefer, Brian C., additional, Chen, Kaiwen W., additional, Broz, Petr, additional, and Brodsky, Igor E., additional

Published
2021
Full Text
View/download PDF

8. IRF2 transcriptionally induces GSDMD expression for pyroptosis

Author

Kayagaki, Nobuhiko, primary, Lee, Bettina L., additional, Stowe, Irma B., additional, Kornfeld, Opher S., additional, O'Rourke, Karen, additional, Mirrashidi, Kathleen M., additional, Haley, Benjamin, additional, Watanabe, Colin, additional, Roose-Girma, Merone, additional, Modrusan, Zora, additional, Kummerfeld, Sarah, additional, Reja, Rohit, additional, Zhang, Yafei, additional, Cho, Vicky, additional, Andrews, T. Daniel, additional, Morris, Lucy X., additional, Goodnow, Christopher C., additional, Bertram, Edward M., additional, and Dixit, Vishva M., additional

Published
2019
Full Text
View/download PDF

15. IRF2 transcriptionally induces GSDMDexpression for pyroptosis

Author

Kayagaki, Nobuhiko, Lee, Bettina L., Stowe, Irma B., Kornfeld, Opher S., O'Rourke, Karen, Mirrashidi, Kathleen M., Haley, Benjamin, Watanabe, Colin, Roose-Girma, Merone, Modrusan, Zora, Kummerfeld, Sarah, Reja, Rohit, Zhang, Yafei, Cho, Vicky, Andrews, T. Daniel, Morris, Lucy X., Goodnow, Christopher C., Bertram, Edward M., and Dixit, Vishva M.

Abstract

Pyroptosis requires the induction of gasdermin D expression by the transcription factor IRF2.

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results