9 results on '"Korhonen, L. (Linda)"'
Search Results
2. Hemolytic uremic syndrome caused by Shiga toxin–producing Escherichia coli in children:incidence, risk factors, and clinical outcome
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Ylinen, E. (Elisa), Salmenlinna, S. (Saara), Halkilahti, J. (Jani), Jahnukainen, T. (Timo), Korhonen, L. (Linda), Virkkala, T. (Tiia), Rimhanen-Finne, R. (Ruska), Nuutinen, M. (Matti), Kataja, J. (Janne), Arikoski, P. (Pekka), Linkosalo, L. (Laura), Bai, X. (Xiangning), Matussek, A. (Andreas), Jalanko, H. (Hannu), and Saxén, H. (Harri)
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Shiga toxin subtypes ,Shiga toxin-producing E.coli (STEC) ,hemic and lymphatic diseases ,Shiga toxins ,Hemolytic uremic syndrome ,Kidney failure ,urologic and male genital diseases - Abstract
Background: Hemolytic uremic syndrome (HUS) is a multisystemic disease. In a nationwide study, we characterized the incidence, clinical course, and prognosis of HUS caused by Shiga toxin (Stx)–producing Escherichia coli (STEC) strains with emphasis on risk factors, disease severity, and long-term outcome. Methods: The data on pediatric HUS patients from 2000 to 2016 were collected from the medical records. STEC isolates from fecal cultures of HUS and non-HUS patients were collected from the same time period and characterized by whole genome sequencing analysis. Results: Fifty-eight out of 262 culture-positive cases developed verified (n = 58, 22%) STEC-HUS. Another 29 cases had probable STEC-HUS, the annual incidence of STEC-HUS being 0.5 per 100,000 children. Eleven different serogroups were detected, O157 being the most common (n = 37, 66%). Age under 3 years (OR 2.4), stx2 (OR 9.7), and stx2a (OR 16.6) were found to be risk factors for HUS. Fifty-five patients (63%) needed dialysis. Twenty-nine patients (33%) developed major neurological symptoms. Complete renal recovery was observed in 57 patients after a median 4.0 years of follow-up. Age under 3 years, leukocyte count over 20 × 10⁹/L, and need for dialysis were predictive factors for poor renal outcome. Conclusions: Age under 3 years, stx2, and stx2a were risk factors for HUS in STEC-positive children. However, serogroup or stx types did not predict the renal outcome or major CNS symptoms.
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- 2020
3. A single genetic locus associated with pediatric fractures:a genome-wide association study on 3,230 patients
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Parviainen, R. (Roope), Skarp, S. (Sini), Korhonen, L. (Linda), Serlo, W. (Willy), Männikkö, M. (Minna), and Sinikumpu, J.-J. (Juha-Jaakko)
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genome-wide association study ,children ,genetics ,cohort ,fractures ,risk - Abstract
The understanding of the biological and environmental risk factors of fractures in pediatrics is limited. Previous studies have reported that fractures involve heritable traits, but the genetic factors contributing to the risk of fractures remain elusive. Furthermore, genetic influences specific to immature bone have not been thoroughly studied. Therefore, the aim of the present study was to identify genetic variations that are associated with fractures in early childhood. The present study used a prospective Northern Finland Birth Cohort (year 1986; n=9,432). The study population was comprised of 3,230 cohort members with available genotype data. A total of 48 members of the cohort (1.5%) had in‑hospital treated bone fractures during their first 6 years of life. Furthermore, individuals without fracture (n=3,182) were used as controls. A genome‑wide association study (GWAS) was performed using a frequentist association test. In the GWAS analysis, a linear regression model was fitted to test for additive effects of single‑nucleotide polymorphisms (SNPs; genotype dosage) adjusting for sex and performing population stratification using genotypic principal components. Using the GWAS analysis, the present study identified one locus with a significant association with fractures during childhood on chromosome 10 (rs112635931) and six loci with a suggested implication. The lead SNP rs112635931 was located near proline‑ and serine‑rich 2 (PROSER2) antisense RNA 1 (PROSER2‑AS1) and PROSER2, thus suggesting that these may be novel candidate genes associated with the risk of pediatric fractures.
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- 2020
4. The association of metal frame construct of ESIN and radiographic bone healing of pediatric forearm fractures
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Korhonen, L. (Linda), Lutz, N. (Nicolas), Sinikumpu, J.-J. (Juha-Jaakko), Korhonen, L. (Linda), Lutz, N. (Nicolas), and Sinikumpu, J.-J. (Juha-Jaakko)
- Abstract
Introduction: The gold-standard surgical procedure of both-bone forearm shaft fracture repair is elastic stable intramedullary nailing (ESIN). Disadvantages effects of ESIN have suggested to be a consequence of inappropriate surgical techniques, while recommendations are not always followed. The purpose of the study was to analyze the effect of inadequate metal frame construct on impaired fracture healing, refracture and changing alignment. Materials and methods: It is a population-based study including all consecutive patients, aged less than 16 years, who had been treated for forearm shaft fracture by ESIN during the ten-year period 2009–2018. Altogether 71 patients were included. Non-union, delayed union, and re-fracture during the following 12 months were taken as the main outcome, while inferior metal frame construct of ESIN and the surgical technique characteristics were taken the explanatory factors. Radiographic loss of reduction was a secondary outcome and a change >5° in alignment at any postoperative follow-up exam was recognized. Results: Two out of 71 fractures (3%) failed to unite, and ossifying operation was needed. Five cases (7%) showed delayed bone healing, but they ossified in five months without any intervention. These seven patients (10%) had been treated more often with larger nails (> 0.7x MCD) (p = 0.027) and by open reduction (p = 0.02), compared with thinner nails and closed reduction, respectively. Two (3%) patients had a second fracture; however, they happened 2 years after the initial injury. Other surgery or fracture related factors didn’t associate with impaired ossifying. Regarding the secondary outcome, altogether 24 (35%) of the analyzed 67 patients showed >5° change in alignment during the postoperative follow-up but only one patient had clinically significant instability that required re-reduction. The alignment changed more usually in distal-third fractures, compared with middle or proximal third fractures (p = 0.019). C
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- 2020
5. Pediatric forearm fractures with special reference to operatively treated shaft fractures and ulnar styloid process nonunion
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Sinikumpu, J. (Juha-Jaakko), Serlo, W. (Willy), Korhonen, L. (Linda), Sinikumpu, J. (Juha-Jaakko), Serlo, W. (Willy), and Korhonen, L. (Linda)
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During childhood, the forearm is the most typical area to succumb to fractures. Of these fractures, shaft fractures and ulnar styloid process (USP) fractures are overwhelmingly associated with impaired union. Elastic stable intramedullary nailing (ESIN) is the preferred surgical treatment method for shaft fractures; yet, the method has its limitations. ESIN is not always performed according to recommendations, resulting in inferior outcomes. Furthermore, there are limitations in traditional methods to measure the function during follow-up, clinically. The rate and risk factors of USP nonunion are mostly unknown. This study aimed to compare the new surgical method, biodegradable intramedullary nailing (BIN), with ESIN. Another aim was to critically analyze the tension metal frame construct of two pre-bended, opposing nails in ESIN. The congruence between the new computer-assisted measuring method and handheld goniometer/dynamometer was aimed to be researched, as well as the rate and long-term morbidity of USP nonunion. Biodegradable nails were produced of poly(L-lactide-co-glycolide) (PLGA) for the purposes of the study. A randomized trial was performed using either BIN or ESIN, and outcomes were evaluated at the two-year mark. The technical deviations of ESIN, as compared with the current recommendations, were studied in a retrospective cohort. E-link was analyzed through comparative study. The rate of USP nonunion in the patients with a previous distal forearm fracture was analyzed with a mean of 11 years of follow-up. The two-year clinical outcomes of forearm shaft fractures were good regardless of the BIN or ESIN treatment option. Two unexpected refractures occurred in adolescents treated with BIN. The recommended tension metal frame in ESIN was not achieved in 79% of the cases. Thicker nails and open reduction were associated with impaired bone healing. The computer-assisted measuring method was feasible in practice but not congruent with the traditiona, Tiivistelmä Lapsilla luun murtumat ovat kaikkein yleisimpiä kyynärvarren alueella. Kyynärvarren murtumista putkiluun keskiosan kahden luun murtumat sekä kyynärluun distaalisen puikkolisäkkeen murtumat ovat alttiita komplikaatioille. Tutkimuksen tavoitteena oli selvittää kyynärvarren keskiosan murtumien hoitoa uudella ydinnaulaustekniikalla käyttäen sulavia ydinnauloja (biodegradable intramedullary nailing, BIN). Lisäksi tavoitteena oli tutkia joustavan ydinnaulauksen (elastic stable intramedullary nailing, ESIN) teknistä onnistumista. Tavoitteena oli tutkia yläraajamurtuman kliinisten myöhäistuloksien mittaamista tietokoneavusteisella menetelmällä sekä selvittää kyynärluun puikkolisäkkeen (ulnar styloid process, USP) luutumattomuutta. Sulavien ydinnaulojen kahden vuoden tuloksia verrattiin titaanisilla joustavilla ydinnauloilla hoidettuihin potilaisiin satunnaistetussa, etenevässä hoitokokeessa. ESIN:n muodostaman jännitteisen, metallisen kaksoiskaaren saavuttamista analysoitiin taannehtivasti sairaalan potilasaineistossa. Tietokoneavusteista mittausmenetelmää tutkittiin vertailevassa työssä ja USP:n luutumattomuudesta seuraavia pitkäaikaistuloksia arvioitiin pitkäaikaisessa (keskimäärin 11 v.) seurantatutkimuksessa. Sulavilla ydinnauloilla hoidettujen potilaiden 2-vuoden liikeala ja puristusvoimat olivat yhtä hyvät kuin titaanisilla nauloilla hoidetuilla. Titaaniset esitaivutetut ydinnaulat oli useimmilla (79 %) potilailla aseteltu vastoin suositusta niin, että ydinnaulat eivät muodostaneet jännitteistä kaksoiskaarikehikkoa. Tietokoneavusteisen mittauksen etuna oli vaivattomuus, mutta mittaustulokset eivät olleet yhtenevät perinteisen kulma- ja puristusvoimamittauksen kanssa. Puikkolisäkkeen luutumattomuus oli yleistä (16 %) rannemurtuman jälkeen, mutta oireita oli harvalla. Puolet puikkolisäkkeen murtumista oli jäänyt alun perin havaitsematta.
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- 2020
6. Non-union of the ulnar styloid process in children is common but long-term morbidity is rare:a population-based study with mean 11 years (9–15) follow-up
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Korhonen, L. (Linda), Victorzon, S. (Sarita), Serlo, W. (Willy), and Sinikumpu, J.-J. (Juha-Jaakko)
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musculoskeletal diseases ,body regions - Abstract
Background and purpose: Fracture of the ulnar styloid process (USP) is common in children in connection with distal radius fracture. The long-term morbidity of USP non-union following a childhood distal radius fracture is unclear. We evaluated long-term clinical and radiographic findings of USP non-union. Patients and methods: All 208 children (< 16 years) who had suffered from distal radius fracture with or without a diagnosed concomitant ulnar fracture during 1992–1999 in the study institution were invited to follow-up at mean of 11 years (9–15) after the injury. Radiographs of both wrists of all 139 participants (67%) were taken; 22 patients showed USP non-union and they made up the study population. Distal radioulnar joint (DRUJ) instability, decreased range of motion (ROM), and weakened grip strength as compared with the uninjured side were the main functional outcomes. Elements of the “Disability of Arm, Shoulder and Hand” questionnaire were used for subjective symptoms. Results: The rate of USP non-union following childhood distal forearm fracture was 16% (22/139) and only 9 of the ulnar styloid fractures were visible in the radiographs primarily. At follow-up wrist flexion–extension ROM and ulnar and radial deviation ranges did not differ between the injured and uninjured sides. Grip strengths were similar. 6 patients reported pain during exercise. 7 had ulna minus (mean 2.3 mm) but none showed degenerative radiographic findings. Interpretation: The long-term clinical results of USP non-union following a childhood wrist fracture were good. However, one-third of the patients with USP non-union had ulnar shortening, which may predispose them to degenerative processes later in life.
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- 2019
7. Recent trends in children’s elbow dislocation with or without a concomitant fracture
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Hyvönen, H. (Hanna), Korhonen, L. (Linda), Hannonen, J. (Juuli), Serlo, W. (Willy), and Sinikumpu, J.-J. (Juha-Jaakko)
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Fracture ,Operative treatment ,Incidence ,Elbow dislocation ,Children ,Non-operative treatment - Abstract
Background: The elbow is the joint that most usually dislocates in children. In contrast to the widely known recent increase in the incidence of upper-extremity fractures and their operative treatment in children, potential trends in elbow dislocation are not clear. In this study we aimed to clarify the recent epidemiology of childhood elbow dislocation, in particular the potential change in incidence and treatment. Methods: A population-based study was performed to evaluate the annual incidence and the characteristics of injury, patients and treatment. All children
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- 2019
8. The incidence and treatment trends of pediatric proximal humerus fractures
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Hannonen, J. (Juuli), Hyvönen, H. (Hanna), Korhonen, L. (Linda), Serlo, W. (Willy), Sinikumpu, J.-J. (Juha-Jaakko), Hannonen, J. (Juuli), Hyvönen, H. (Hanna), Korhonen, L. (Linda), Serlo, W. (Willy), and Sinikumpu, J.-J. (Juha-Jaakko)
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Background: Proximal humerus fractures comprise approximately 2% of all pediatric fractures. In general, upper extremity fractures have increased in children. However, recent trends of proximal humerus fractures are not analyzed yet. The aim was to study the incidence and treatment trends of proximal humerus fractures in children. Methods: All 300 children, aged < 16 years, who suffered from a proximal humerus fracture in the catchment area of Oulu University Hospital, Finland, between 2005 and 2015, were included. Radiographs were reviewed, and patients, injuries, treatments, and outcomes were comprehensively studied. Annual incidence was based on the child population at risk, which changed between 84.500 and 88.100 in the study time. Results: The annual incidence of childhood proximal humerus fractures was mean 31.4/100,000 and no variation trend was found. The majority (92%) was treated nonoperatively, however, there was an increase of operative fixation from 0 to 16% during the study time (Difference 16, 95% CI 0.3 to 34.9%, P = 0.045). Bayonet displacement increased the risk of surgical fixation up to 16-fold (95% CI 4.8–51.4, P < 0.001) in a multivariate analysis when adjusted with other potential risk factors. Higher age was also associated with operative treatment (P = 0.002). The most usual recreational activities were horse riding, downhill skiing, snowboarding, and trampolining. Conclusion: Contrary to most upper extremity fractures in children, proximal humerus fractures did not increase during the long study period. However, their operative treatment increased compared to nonoperative treatment, but the evidence supporting that trend remains unclear.
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- 2019
9. Intramedullary nailing of forearm shaft fractures by biodegradable compared with titanium nails:results of a prospective randomized trial in children with at least two years of follow-up
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Korhonen, L. (Linda), Perhomaa, M. (Marja), Kyrö, A. (Antti), Pokka, T. (Tytti), Serlo, W. (Willy), Merikanto, J. (Juhani), and Sinikumpu, J.-J. (Juha-Jaakko)
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body regions ,integumentary system ,Paediatric ,education ,Forearm shaft fractures ,Intramedullary nailing ,Biodegradable - Abstract
There are disadvantages in Elastic Stable Intramedullary Nailing (ESIN) of forearm-shaft fractures, such as the need of implant removal. Biodegradable Intramedullary Nailing (BIN) is a new technique developed for these fractures. We hypothesized that there is no difference in rotational ROM between the patients treated by BIN vs. ESIN. A randomized, controlled clinical trial included patients, aged 5–15 years, requiring surgery for forearm-shaft fractures. Biodegradable polylactide-co-glycolide (PLGA) nails (Activa IM-Nail™, Bioretec Ltd., Finland) were used in 19 and titanium nails (TEN®, SynthesDePuy Ltd., USA) in 16 patients. Rotational ROM of forearm after two years was the primary outcome. Elbow and wrist ROM, pain and radiographic bone healing were secondary outcomes. Forearm rotation was mean 162° and 151° in BIN and ESIN groups, respectively (P = 0.201). No difference between the groups was found in any other ROMs. Three cases in the ESIN vs. none in the BIN group reported pain (P = 0.113). There was no clinically significant residual angulation in radiographs. Two adolescents in the BIN group vs. none in the ESIN (P = 0.245) were excluded because of implant failure; another two with complete bone union suffered from re-injury. Therefore, satisfactory implant stability among older children needs to be studied.
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- 2018
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