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INTRODUCTION: Intracerebral abscess is a health problem that also has a long duration of hospitalization and antibiotic therapy due to the long treatment process after surgery.There are many parameters that can shorten these two periods. The surgical method chosen for abscess excision or aspiration is one of these parameters.In light of our own clinical experience, we compared the method of abscess aspiration with burr-hole accompanied by neuronavigation and the method of abscess excision with craniotomy accompanied by neuronavigation to show the effect of these methods on hospitalization and antibiotic therapy time. METHODS: 48 intracerebral abscess cases operated using these two methods in the last 10 years were retrospectively examined in our clinic. The data of 16 parameters examined separately for both methods were comparatively revealed and their effect on hospitalization and antibiotic therapy times was investigated. RESULTS: In the evaluation of the average duration of antibiotic therapies used by patients while they were hospitalized and after their discharge, it was found that this period was 6.62 weeks (46.34 days) in the group of abscess aspiration with burr-hole accompanied by neuronavigation, and 7.56 weeks (52.92 days) in the other group. The duration of hospitalization of patients was 14.62 days on average in the group of abscess aspiration with burr-hole accompanied by neuronavigation, and 19.18 days on average in the other group. DISCUSSION AND CONCLUSION: In contrast to many studies, patients with burr-hole abscess aspiration accompanied by neuronavigation had higher neurological recovery rates after surgery, and hospitalization times and antibiotic therapy times were shorter than the other method.