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24 results on '"Korecka, Joanna A."'

1. Contributors

Author

Abdulai-Saiku, Samira, primary, Appel, Stanley H., additional, Arnold, Arthur P., additional, Arnold, Lisa M., additional, Arnold, Robert M., additional, Bacha, Alexa, additional, Backonja, Miroslav “Misha”, additional, Bailey, Zinzi D., additional, Bateman, Lucinda, additional, Beers, David R., additional, Berti, Anna, additional, Bhatnagar, Mamta, additional, Binder, Devin K., additional, Boido, Marina, additional, Boldrini, Maura, additional, Borsook, David, additional, Breakefield, Xandra O., additional, Brown, Robert H., additional, Burstein, Rami, additional, Butelman, Eduardo R., additional, Caplan, Louis R., additional, Chen, S., additional, Chesselet, Marie-Françoise, additional, Clemens, Stefan, additional, Clemens, Paula R., additional, Coyle, Joseph T., additional, DeWitt, John C., additional, Dubal, Dena B., additional, Dubljević, Veljko, additional, Feldman, Eva L., additional, Fischer, Beth A., additional, Flux, M.C., additional, Fortin, J.S., additional, Frasca, Angelisa, additional, Garbarini, Francesca, additional, Gasser, Thomas, additional, Gillespie, Charles F., additional, Gold, Michael S., additional, Gold, Stefan M., additional, Hagerman, Randi, additional, Hamel, Regan, additional, Haney, Craig, additional, Harris, James C., additional, Hassani, Sara, additional, Haughey, Norman J., additional, Heng, Vibol, additional, Horn, J., additional, Ionescu, Rosana-Bristena, additional, Iorio, Raffaele, additional, Irwin, David J., additional, Kaminski, Henry J., additional, Khammash, Dalia, additional, Khurana, Vikram, additional, Kilstrup-Nielsen, Charlotte, additional, Kim, Bhumsoo, additional, Kim, Boram, additional, Klein, Marieke, additional, Koen, Nastassja, additional, Konopaske, Glenn T., additional, Korecka, Joanna A., additional, Kornum, Birgitte Rahbek, additional, Kreek, Mary Jeanne, additional, Kristensson, Krister, additional, Krzak, Grzegorz, additional, Kusner, Linda L., additional, Landsberger, Nicoletta, additional, Lee, Edward B., additional, Li, Tong, additional, Liberski, Paweł P., additional, Lochner, Christine, additional, Lowry, Christopher A., additional, Mann, J. John, additional, Marincowitz, Clara, additional, Mayer, E.A., additional, Mayer, E.D., additional, McCall, Iris Coates, additional, McCullough, Louise D., additional, Meaney, Michael J., additional, Melo de Gusmao, Claudio, additional, Menesgere, Abhishek L., additional, Mignot, Emmanuel, additional, Mobley, William C., additional, Montalvo, Mayra, additional, Moreland-Capuia, Alisha R., additional, Neppi-Modona, Marco, additional, Nicaise, Alexandra M., additional, Nishi, Rae, additional, O'Toole, Orna, additional, Overk, Cassia, additional, Ozelius, Laurie, additional, Parsons, Matthew P., additional, Penticoff, H.B., additional, Peruzzotti-Jametti, Luca, additional, Peters, Owen M., additional, Peterson, Allison, additional, Phan, Jessica M., additional, Pittock, Sean J., additional, Pluchino, Stefano, additional, Polk, Thad A., additional, Puwanant, Araya, additional, Rajagopal, Shreya K., additional, Ravindranath, Vijayalakshmi, additional, Raymond, Lynn A., additional, Reed, Brian, additional, Ressler, Kerry J., additional, Ritchie, Diane L., additional, Rubin, Leah H., additional, Sakowski, Stacey A., additional, Saporta, Mario A., additional, Savonenko, Alena V., additional, Scharfman, Helen E., additional, Shapiro, Bruce K., additional, Sharma, Nutan, additional, Shaw, Cayce K., additional, Shy, Michael E., additional, Sikorska, Beata, additional, Silverman, Ethan J., additional, Simon, Roger P., additional, Simonyan, Kristina, additional, Sims-Robinson, Catrina, additional, Smeyne, Richard Jay, additional, Smith, Clay, additional, Smith, Colin, additional, Srinivasan, Sharan R., additional, Stein, Dan J., additional, Stephen, Christopher D., additional, Subramanian, Indu, additional, Szabo, Edina, additional, Thomas, Alissa A., additional, Tovar-y-Romo, Luis B., additional, Vahabzadeh, Arshya, additional, Vercelli, Alessandro, additional, Viera-Ortiz, Ashley, additional, Wallin, Mitchell T., additional, Werling, Donna M., additional, Wichmann, Thomas, additional, Wiley, Clayton A., additional, Williams, David R., additional, Willis, Cory, additional, Wong, Philip C., additional, Yuferov, Vadim, additional, Zhao, Weihua, additional, Zigmond, Michael J., additional, and Živković, Saša A., additional

Published
2023
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5. Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons

Author

Cronin, Shane J.F., primary, Yu, Weonjin, additional, Hale, Ashley, additional, Crabtree, Mark, additional, Korecka, Joanna, additional, Sealey, Marco, additional, Licht-Mayer, Simon, additional, Turnes, Bruna, additional, da Luz Scheffer, Debora, additional, Somlyay, Mate, additional, Cikes, Domagoj, additional, Nagy, Vanja, additional, Wolf, Alexandra, additional, Reither, Harald, additional, Weidinger, Adelheid, additional, Chabloz, Antoine, additional, Kavirayani, Anoop, additional, Rao, Shuan, additional, Andrews, Nick, additional, Latremoliere, Alban, additional, Costigan, Michael, additional, Kozlov, Andrey, additional, Douglas, Gillian, additional, Freitas, Fernando Cini, additional, Pifl, Christian, additional, Konrat, Robert, additional, Mahad, Don J., additional, Bagby, Stefan, additional, Isacson, Ole, additional, Walz, Roger, additional, Hallett, Penelope, additional, Latini, Alexandra, additional, Woolf, Clifford J., additional, Je, Shawn, additional, Channon, Keith, additional, Penninger, Josef, additional, Tretiakov, Evgenii, additional, Onji, Masahiro, additional, An, Meilin, additional, Fox, Jesse, additional, Gomez-Diaz, Carlos, additional, and Harkany, Tibor, additional

Published
2023
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11. Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity

Author

Brekk, Oeystein R., primary, Korecka, Joanna A., additional, Crapart, Cecile C., additional, Huebecker, Mylene, additional, MacBain, Zachary K., additional, Rosenthal, Sara Ann, additional, Sena-Esteves, Miguel, additional, Priestman, David A., additional, Platt, Frances M., additional, Isacson, Ole, additional, and Hallett, Penelope J., additional

Published
2020
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14. Small Scale Production of Recombinant Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System

Author

Verhaagen, J., Hobo, B., Ehlert, Erich M E, Eggers, R., Korecka, Joanna A, Hoyng, Stefan A, Attwell, Callan L, Harvey, Alan R, Mason, Matthew R J, and Netherlands Institute for Neuroscience (NIN)

Subjects
Journal Article
Abstract

Adeno-associated viral vectors have numerous applications in neuroscience, including the study of gene function in health and disease, targeting of light-sensitive proteins to anatomically distinct sets of neurons to manipulate neuronal activity (optogenetics), and the delivery of fluorescent protein to study anatomical connectivity in the brain. Moreover several phase I/II clinical trials for gene therapy of eye and brain diseases with adeno-associated viral vectors have shown that these vectors are well tolerated by human patients. In this chapter we describe a detailed protocol for the small scale production of recombinant adeno-associated viral vectors. This protocol can be executed by investigators with experience in cell culture and molecular biological techniques in any well-equipped molecular neurobiology laboratory. With this protocol we typically obtain research batches of 100-200 μL that range in titer from 5 × 1012 to 2 × 1013 genomic copies/mL.

Published
2018

15. Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson's Disease

Author

Korecka, Joanna A., primary, Moloney, Elizabeth B., additional, Eggers, Ruben, additional, Hobo, Barbara, additional, Scheffer, Sanny, additional, Ras-Verloop, Nienke, additional, Pasterkamp, R. Jeroen, additional, Swaab, Dick F., additional, Smit, August B., additional, van Kesteren, Ronald E., additional, Bossers, Koen, additional, and Verhaagen, Joost, additional

Published
2017
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16. Repulsive guidance molecule a (RGMa) induces neuropathological and behavioral changes that closely resemble parkinson’s disease

Author

Korecka, Joanna A, Moloney, Elizabeth B., Eggers, Ruben, Hobo, Barbara, Scheffer, Sanny, Ras-Verloop, Nienke, Jeroen Pasterkamp, R., Swaab, Dick F., Smit, August B, van Kesteren, Ronald E., Bossers, Koen, Verhaagen, Joost, Korecka, Joanna A, Moloney, Elizabeth B., Eggers, Ruben, Hobo, Barbara, Scheffer, Sanny, Ras-Verloop, Nienke, Jeroen Pasterkamp, R., Swaab, Dick F., Smit, August B, van Kesteren, Ronald E., Bossers, Koen, and Verhaagen, Joost

Published
2017

17. Repulsive guidance molecule a (RGMa) induces neuropathological and behavioral changes that closely resemble parkinson’s disease

Author

UMC Utrecht, TN groep Pasterkamp, Brain, Regenerative Medicine and Stem Cells, Korecka, Joanna A, Moloney, Elizabeth B., Eggers, Ruben, Hobo, Barbara, Scheffer, Sanny, Ras-Verloop, Nienke, Jeroen Pasterkamp, R., Swaab, Dick F., Smit, August B, van Kesteren, Ronald E., Bossers, Koen, Verhaagen, Joost, UMC Utrecht, TN groep Pasterkamp, Brain, Regenerative Medicine and Stem Cells, Korecka, Joanna A, Moloney, Elizabeth B., Eggers, Ruben, Hobo, Barbara, Scheffer, Sanny, Ras-Verloop, Nienke, Jeroen Pasterkamp, R., Swaab, Dick F., Smit, August B, van Kesteren, Ronald E., Bossers, Koen, and Verhaagen, Joost

Published
2017

20. Human neuroma contains increased levels of semaphorin 3A, which surrounds nerve fibers and reduces neurite extension in vitro

Author

Tannemaat, Martijn R, Korecka, Joanna, Ehlert, Erich M E, Mason, Matthew R J, van Duinen, Sjoerd G, Boer, Gerard J, Malessy, Martijn J A, Verhaagen, J., Tannemaat, Martijn R, Korecka, Joanna, Ehlert, Erich M E, Mason, Matthew R J, van Duinen, Sjoerd G, Boer, Gerard J, Malessy, Martijn J A, and Verhaagen, J.

Abstract

Neuroma formation after peripheral nerve injury is detrimental to functional recovery and is therefore a significant clinical problem. The molecular basis for this phenomenon is not fully understood. Here, we show that the expression of the chemorepulsive protein semaphorin 3A (sema3A), but not semaphorin 3F, is increased in human neuroma tissue that has formed in severe obstetric brachial plexus lesions. Sema3A is produced by fibroblasts in the epineurial space and appears to be secreted into the extracellular matrix. It surrounds fascicles, minifascicles, or single axons, suggesting a role in fasciculation and inhibition of neurite outgrowth. Lentiviral vector-mediated knock-down of Neuropilin 1, the receptor for sema3A, leads to increased neurite outgrowth of F11 cells cultured on neuroma tissue, but not of F11 cells cultured on normal nerve tissue. These findings demonstrate the putative inhibitory role of sema3A in human neuroma tissue. Our observations are the first demonstration of the expression of sema3A in human neural scar tissue and support a role for this protein in the inhibition of axonal regeneration in injured human peripheral nerves. These findings contribute to the understanding of the outgrowth inhibitory properties of neuroma tissue.

Published
2007

22. Human Neuroma Contains Increased Levels of Semaphorin 3A, Which Surrounds Nerve Fibers and Reduces Neurite Extension In Vitro.

Author

Tannemaat, Martijn R., Korecka, Joanna, Ehlert, Erich M. E., Mason, Matthew R. J., Van Duinen, Sjoerd G., Boer, Gerard J., Malessy, Martijn J. A., and Verhaagen, Joost

Subjects
*NEUROMAS, *SEMAPHORINS, *NERVE fibers, *PERIPHERAL nervous system, *BRACHIAL plexus
Abstract

Neuroma formation after peripheral nerve injury is detrimental to functional recovery and is therefore a significant clinical problem. The molecular basis for this phenomenon is not fully understood. Here, we show that the expression of the chemorepulsive protein semaphorin 3A (sema3A), but not semaphorin 3F, is increased in human neuroma tissue that has formed in severe obstetric brachial plexus lesions. Sema3A is produced by fibroblasts in the epineurial space and appears to be secreted into the extracellular matrix. It surrounds fascicles, minifascicles, or single axons, suggesting a role in fasciculation and inhibition of neurite outgrowth. Lentiviral vector-mediated knock-down of Neuropilin 1, the receptor for sema3A, leads to increased neurite outgrowth of F11 cells cultured on neuroma tissue, but not of F11 cells cultured on normal nerve tissue. These findings demonstrate the putative inhibitory role of sema3A in human neuroma tissue. Our observations are the first demonstration of the expression of sema3A in human neural scar tissue and support a role for this protein in the inhibition of axonal regeneration in injured human peripheral nerves. These findings contribute to the understanding of the outgrowth inhibitory properties of neuroma tissue. [ABSTRACT FROM AUTHOR]

Published
2007
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23. Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons.

Author

Cronin SJF, Yu W, Hale A, Licht-Mayer S, Crabtree MJ, Korecka JA, Tretiakov EO, Sealey-Cardona M, Somlyay M, Onji M, An M, Fox JD, Turnes BL, Gomez-Diaz C, da Luz Scheffer D, Cikes D, Nagy V, Weidinger A, Wolf A, Reither H, Chabloz A, Kavirayani A, Rao S, Andrews N, Latremoliere A, Costigan M, Douglas G, Freitas FC, Pifl C, Walz R, Konrat R, Mahad DJ, Koslov AV, Latini A, Isacson O, Harkany T, Hallett PJ, Bagby S, Woolf CJ, Channon KM, Je HS, and Penninger JM

Abstract

Dopa-responsive dystonia (DRD) and Parkinson's disease (PD) are movement disorders caused by the dysfunction of nigrostriatal dopaminergic neurons. Identifying druggable pathways and biomarkers for guiding therapies is crucial due to the debilitating nature of these disorders. Recent genetic studies have identified variants of GTP cyclohydrolase-1 (GCH1), the rate-limiting enzyme in tetrahydrobiopterin (BH4) synthesis, as causative for these movement disorders. Here, we show that genetic and pharmacological inhibition of BH4 synthesis in mice and human midbrain-like organoids accurately recapitulates motor, behavioral and biochemical characteristics of these human diseases, with severity of the phenotype correlating with extent of BH4 deficiency. We also show that BH4 deficiency increases sensitivities to several PD-related stressors in mice and PD human cells, resulting in worse behavioral and physiological outcomes. Conversely, genetic and pharmacological augmentation of BH4 protects mice from genetically- and chemically induced PD-related stressors. Importantly, increasing BH4 levels also protects primary cells from PD-affected individuals and human midbrain-like organoids (hMLOs) from these stressors. Mechanistically, BH4 not only serves as an essential cofactor for dopamine synthesis, but also independently regulates tyrosine hydroxylase levels, protects against ferroptosis, scavenges mitochondrial ROS, maintains neuronal excitability and promotes mitochondrial ATP production, thereby enhancing mitochondrial fitness and cellular respiration in multiple preclinical PD animal models, human dopaminergic midbrain-like organoids and primary cells from PD-affected individuals. Our findings pinpoint the BH4 pathway as a key metabolic program at the intersection of multiple protective mechanisms for the health and function of midbrain dopaminergic neurons, identifying it as a potential therapeutic target for PD., Competing Interests: Declaration of interest The authors declare no conflict of interest.

Published
2023
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24. Small Scale Production of Recombinant Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System.

Author

Verhaagen J, Hobo B, Ehlert EME, Eggers R, Korecka JA, Hoyng SA, Attwell CL, Harvey AR, and Mason MRJ

Subjects
Brain Diseases genetics, Eye Diseases genetics, Eye Diseases therapy, HEK293 Cells, Humans, Injections, Intraocular methods, Nervous System metabolism, Plasmids, Brain Diseases therapy, Dependovirus genetics, Gene Transfer Techniques, Genetic Therapy methods, Genetic Vectors
Abstract

Adeno-associated viral vectors have numerous applications in neuroscience, including the study of gene function in health and disease, targeting of light-sensitive proteins to anatomically distinct sets of neurons to manipulate neuronal activity (optogenetics), and the delivery of fluorescent protein to study anatomical connectivity in the brain. Moreover several phase I/II clinical trials for gene therapy of eye and brain diseases with adeno-associated viral vectors have shown that these vectors are well tolerated by human patients. In this chapter we describe a detailed protocol for the small scale production of recombinant adeno-associated viral vectors. This protocol can be executed by investigators with experience in cell culture and molecular biological techniques in any well-equipped molecular neurobiology laboratory. With this protocol we typically obtain research batches of 100-200 μL that range in titer from 5 × 10 12 to 2 × 10 13 genomic copies/mL.

Published
2018
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