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504 results on '"Kordon C"'

2. Ghrelin: From GH Control to Feeding Behaviour and Sleep Regulatio

Author

Bluet-Pajot, M.-T., Tolle, V., Bassant, M.-H., Kordon, C., Zizzari, P., Poindessous-Jazat, F., Tomasetto, C., Rio, M. C., Estour, B., Foulon, C., Dardennes, R., Epelbaum, J., Kordon, Claude, editor, Robinson, Iain, editor, Hanoune, Jacques, editor, Dantzer, Robert, editor, and Christen, Yves, editor

Published
2003
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5. Ghrelin: From GH Control to Feeding Behaviour and Sleep Regulatio

Author

Bluet-Pajot, M.-T., primary, Tolle, V., additional, Bassant, M.-H., additional, Kordon, C., additional, Zizzari, P., additional, Poindessous-Jazat, F., additional, Tomasetto, C., additional, Rio, M. C., additional, Estour, B., additional, Foulon, C., additional, Dardennes, R., additional, and Epelbaum, J., additional

Published
2002
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8. Multifactorial regulation of growth hormone

Author

Berthelier, C., Bertrand, P., Bluet-Pajot, M. T., Clauser, H., Durand, D., Enjalbert, A., Epelbaum, J., Rerat, E., Kordon, C., MÜller, Eugenio E., editor, Cocchi, Daniela, editor, and Locatelli, Vittorio, editor

Published
1989
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10. The effect of neuropeptides on human trust and altruism: a neuroeconomic perspective

Author

Pfaff, D, Kordon, C, Chanson, P, Christen, Y, Pfaff, D ( D ), Kordon, C ( C ), Chanson, P ( P ), Christen, Y ( Y ), Fehr, Ernst; https://orcid.org/0000-0001-6325-7821, Pfaff, D, Kordon, C, Chanson, P, Christen, Y, Pfaff, D ( D ), Kordon, C ( C ), Chanson, P ( P ), Christen, Y ( Y ), and Fehr, Ernst; https://orcid.org/0000-0001-6325-7821

Published
2008

18. Twins and the fetal origins hypothesis: an application to growth data

Author

Boomsma, D.I., Willemsen, G., de Geus, E.J.C., Kupper, H.M., Posthuma, D., IJzerman, R.G., Heijmans, B.T., Slagboom, P.E., Beem, A.L., Dolan, C.V., Kordon, C., Gaillard, R.C., Christen, Y., Biological Psychology, and Functional Genomics

Subjects
Netherlands Twin Register (NTR)
Published
2005

22. Decreased expression of the two D2 dopamine receptor isoforms in bromocriptine-resistant prolactinomas

Author

Laure Caccavelli, Feron F, Morange I, Rouer E, Benarous R, Dewailly D, Jaquet P, Kordon C, and Enjalbert A

Subjects
Adenoma, Adult, Male, Adolescent, Base Sequence, Receptors, Dopamine D2, Molecular Sequence Data, Drug Resistance, Gene Expression, Polymerase Chain Reaction, Alternative Splicing, Growth Hormone, Humans, Female, Pituitary Neoplasms, Prolactinoma, Bromocriptine, Adenylyl Cyclases
Abstract

Bromocriptine or other dopamine agonists are usually effective for the treatment of prolactin-secreting adenomas. Five to 18% of prolactinomas, however, do not respond to such therapy. We have shown previously that such resistance to bromocriptine correlates with reduced binding to the D2 receptor subtype of dopamine, the major PRL inhibiting factor. In the present work, we demonstrated that reduced binding actually corresponds to decreased expression of the gene coding for the D2 receptor in the pituitary from bromocriptine-resistant patients, as shown by 4-fold lower levels of the corresponding mRNAs compared to those coding for actin. The existence of two D2 receptor isoforms, D2S and D2L generated by alternative splicing, has been described in several tissues, including the pituitary. Both are negatively coupled to adenylyl cyclase and inhibit prolactin secretion, but, in addition, the shortest one (D2S) is more efficiently coupled to phospholipase C. Consequently, we also investigated whether expression of a particular D2 receptor isoform was preferentially affected in resistant adenomas. The proportion of messengers corresponding to the short receptor isoform (D2S) was lower in resistant compared to responsive adenomas: D2S/D2L = 0.74 +/- 0.08 and 1.00 +/- 0.07, respectively. In parallel, much lower levels of D2 receptor mRNAs were found in growth hormone-secreting adenomas, with a D2S/D2L ratio comparable to those of both normal human pituitary and bromocriptine-sensitive prolactinomas (1.05 +/- 0.11). Thus, resistance to bromocriptine therapy seems to involve defects in D2 dopamine receptor expression and possibly in posttranscriptional splicing.

Published
1994

23. Selective effect of a diet-induced decrease in the arachidonic acid membrane-phospholipid content on in vitro phospholipase C and adenylate cyclase-mediated pituitary response to angiotensin II

Author

Aléssio, M.L.M., Léger, C.L., Rasolonjanahary, R., Wandscheer, D.E., Clauser, H., Enjalbert, A., KORDON, C., Institut francilien recherche, innovation et société (IFRIS), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)-Institut National de la Recherche Agronomique (INRA)-École des hautes études en sciences sociales (EHESS)-OST-Université Paris-Est Marne-la-Vallée (UPEM)-ESIEE Paris-Centre National de la Recherche Scientifique (CNRS), and Institut National de la Recherche Agronomique (INRA)-École des hautes études en sciences sociales (EHESS)-OST-Université Paris-Est Marne-la-Vallée (UPEM)-Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)-ESIEE Paris-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1994

25. Central Neuropeptide Receptors Involved in Water Balance: Application to Apelin.

Author

Conn, Michael, Kordon, Claude, Christen, Yves, Iturrioz, X., Reaux-Le Goazigo, A., Hus-Citharel, A., Mota, N., Bodineau, L., Frugière, A., Messari, S., Chartrel, N., Kordon, C., Beaudet, A., Vaudry, H., Moos, F., and Llorens-Cortes, C.

Abstract

Because G-protein-coupled receptors (GPCRs) constitute excellent putative therapeutic targets, functional characterization of orphan GPCRs through identification of their endogenous ligands has great potential for drug discovery. In an attempt to identify a receptor specific for angiotensin III, we have cloned, by homology from a rat brain cDNA library, a GPCR that shares 90% amino acid sequence identity with the human orphan APJ (putative receptor protein related to the angiotensin receptor AT1) receptor and 31% with the rat AT1A angiotensin receptor. In 1998, the endogenous ligand for the human orphan APJ receptor, i.e., apelin, was isolated from bovine stomach extracts. Apelin, a bioactive peptide, naturally occurs in the brain and plasma as 13 (pE13F) and 17 amino acid (K17F) fragments of a 77 amino acid precursor. The APJ receptor binds with high affinity K17F and pE13F but not the shorter N-terminal-deleted apelin fragments. This receptor is negatively coupled to adenylate cyclase and internalizes following stimulation with K17F and pE13F. Apelin and its receptor are both widely distributed in the brain and are highly expressed in the supraoptic and paraventricular hypothalamic nuclei. Dual labeling studies demonstrate that, within these two types of nuclei, apelin and its receptor co-localize with vasopressin (AVP) in magnocellular neurons. In lactating rodents, characterized by increases in synthesis and release of AVP, central injection of apelin inhibits the phasic electrical activity of AVP neurons and reduces the secretion of AVP in the bloodstream, resulting in aqueous diuresis. Apelin may thus be considered as a natural inhibitor of the anti-diuretic effect of AVP. Moreover, water deprivation, which increases systemic AVP release, decreases plasma apelin concentrations and induces apelin storage inside magnocellular neurons, thereby avoiding the inhibitory action of apelin on AVP release. Thus apelin and AVP are conversely regulated to optimize systemic AVP release and prevent additional water loss at the kidney level. In addition, apelin and its receptor are present in the cardiovascular system, i.e., in heart, kidney and vessels. Given systemically, apelin reduces arterial blood pressure, increases cardiac contractility and reduces cardiac loading. Apelin may therefore play a crucial role in the control of body fluid homeostasis and cardiovascular functions. A clinical study in healthy volunteers to determine whether apelin controls water balance in humans is in progress. If this hypothesis is confirmed, the development of non-peptide agonists of the apelin receptor may therefore represents new therapeutic avenues for the treatment of water/sodium retention, heart and kidney failure. [ABSTRACT FROM AUTHOR]

Published
2006
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29. GnRH signalling pathways and GnRH-induced homologous desensitization in a gonadotrope cell line (αT3-1)1Preliminary reports of these data were presented at the 2nd Colloque de la Société des Neurosciences (Poulin et al., 1995) and at the 27th meeting of the Society for Neuroscience (Drouva et al., 1997).1

Author

Poulin, B, primary, Rich, N, additional, Mas, J.-L, additional, Kordon, C, additional, Enjalbert, A, additional, and Drouva, S.V, additional

Published
1998
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43. Molecular pharmacology of somatostatin receptors

Author

Viollet, C., primary, Prévost, G., additional, Maubert, E., additional, Faivre-Bauman, A., additional, Gardette, R., additional, Kordon, C., additional, Loudes, C., additional, Slama, A., additional, and Epelbaum, J., additional

Published
1995
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50. A second endogenous molecular form of mammalian hypothalamic luteinizing hormone-releasing hormone (LHRH), (hydroxyproline9)LHRH, releases luteinizing hormone and follicle-stimulating hormone in vitro and in vivo

Author

Gautron, J.P., primary, Leblanc, P., additional, Bluet-Pajot, M.T., additional, Pattou, E., additional, L'Héritier, A., additional, Mounier, F., additional, Ponce, G., additional, Audinot, V., additional, Rasolonjanahary, R., additional, and Kordon, C., additional

Published
1992
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