1. Innate immune responses against Cryptosporidium parvum infection.
- Author
-
McDonald V, Korbel DS, Barakat FM, Choudhry N, and Petry F
- Subjects
- Animals, Cryptosporidiosis parasitology, Humans, Cryptosporidiosis immunology, Cryptosporidium parvum immunology, Immunity, Innate immunology, Intestinal Diseases, Parasitic immunology, Intestinal Diseases, Parasitic parasitology, Zoonoses parasitology
- Abstract
Cryptosporidium parvum infects intestinal epithelial cells and is commonly the parasite species involved in mammalian cryptosporidiosis, a major health problem for humans and neonatal livestock. In mice, immunologically mediated elimination of C. parvum requires CD4+ T cells and IFN-γ. However, innate immune responses also have a significant protective role in both adult and neonatal mice. NK cells and IFN-γ have been shown to be important components in immunity in T and B cell-deficient mice, but IFN-γ-dependent resistance has also been demonstrated in alymphocytic mice. Epithelial cells may play a vital role in immunity as once infected these cells have increased expression of inflammatory chemokines and cytokines and demonstrate antimicrobial killing mechanisms, including production of NO and antimicrobial peptides. Toll-like receptors facilitate the establishment of immunity in mice and are involved in the development of inflammatory responses of infected epithelial cells and also dendritic cells., (© 2012 Blackwell Publishing Ltd.)
- Published
- 2013
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