Search

Your search keyword '"Koppen, Arjen"' showing total 145 results
Start Over Author "Koppen, Arjen"
145 results on '"Koppen, Arjen"'

2. PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation

Author

Madsen, Maria Stahl, Broekema, Marjoleine F., Madsen, Martin Rønn, Koppen, Arjen, Borgman, Anouska, Gräwe, Cathrin, Thomsen, Elisabeth G. K., Westland, Denise, Kranendonk, Mariette E. G., Koerkamp, Marian Groot, Hamers, Nicole, Bonvin, Alexandre M. J. J., Pittol, José M. Ramos, Natarajan, Kedar Nath, Kersten, Sander, Holstege, Frank C. P., Monajemi, Houshang, van Mil, Saskia W. C., Vermeulen, Michiel, Kragelund, Birthe B., Cassiman, David, Mandrup, Susanne, and Kalkhoven, Eric

Published
2022
Full Text
View/download PDF

3. Significant increase in the number of occupational exposures reported to the Dutch Poisons Information Centre (2016-2022): the importance of poison centre data in health surveillance

Author

NVIC, NVIC bedrijfsvoering, Other research (not in main researchprogram), Circulatory Health, Medische Staf Intensive Care, Brain, Infection & Immunity, Wijnands, Anja, Thielman, Maël, Hunault, Claudine, Koppen, Arjen, de Lange, Dylan, Rietjens, Saskia, NVIC, NVIC bedrijfsvoering, Other research (not in main researchprogram), Circulatory Health, Medische Staf Intensive Care, Brain, Infection & Immunity, Wijnands, Anja, Thielman, Maël, Hunault, Claudine, Koppen, Arjen, de Lange, Dylan, and Rietjens, Saskia

Published
2024

4. Risk factors for deliberate self-poisoning among children and adolescents in The Netherlands

Author

NVIC, Other research (not in main researchprogram), Medische Staf Intensive Care, NVIC bedrijfsvoering, Brain, Infection & Immunity, Circulatory Health, Thoonen, Ilze M J, Rietjens, Saskia J, van Velzen, Agnes G, de Lange, Dylan W, Koppen, Arjen, NVIC, Other research (not in main researchprogram), Medische Staf Intensive Care, NVIC bedrijfsvoering, Brain, Infection & Immunity, Circulatory Health, Thoonen, Ilze M J, Rietjens, Saskia J, van Velzen, Agnes G, de Lange, Dylan W, and Koppen, Arjen

Published
2024

5. Significant increase in the number of occupational exposures reported to the Dutch Poisons Information Centre (2016–2022): the importance of poison centre data in health surveillance.

Author

Wijnands, Anja, Thielman, Maël, Hunault, Claudine, Koppen, Arjen, de Lange, Dylan, and Rietjens, Saskia

Subjects
POISONS, SERVER farms (Computer network management), OCCUPATIONAL exposure, HAZARDOUS substance exposure, HAZARDOUS substances, POISONING
Abstract

Exposure to hazardous substances in the workplace can result in injuries and fatalities. This study aimed to investigate the characteristics and trend of occupational exposures reported to the Dutch Poisons Information Centre and to investigate whether the COVID-19 pandemic had an impact on the trend. A retrospective analysis of all acute occupational exposures reported to the Dutch Poisons Information Centre between 1 January 2016 and 31 December 2022 was performed. Data on patient and exposure characteristics, symptoms and treatment recommendations were analyzed. Between 2016 and 2022, the Dutch Poisons Information Centre received 5,508 calls regarding acute occupational exposures. The annual number of calls on acute occupational exposures almost doubled over the years studied (from 475 in 2016 to 936 in 2022). During and after the COVID-19 pandemic (March 2020-December 2022), the number of calls stabilized, but the upward trend was not significantly affected. There were an estimated 0.20 calls per 1,000 human exposure calls per month (95 per cent confidence interval: −0.14; 0.53). Victims were often exposed through multiple routes, with inhalation being the most common route (44 per cent), followed by ocular (32 per cent) and dermal contact (30 per cent). Acids (1,138 exposures) and alkalis (912 exposures) were often involved. The Dutch Poisons Information Centre had information on 6,334 patients, although the total number of exposed patients was not known as some victims did not seek medical assistance, or were treated by healthcare professionals who did not consult our Centre. At the time of contact, 13 per cent (n = 795) of the patients reported no symptoms, 76 per cent (n = 4,805) reported mild to moderate symptoms and 3 per cent (n = 183) reported potentially severe symptoms. Information on symptoms was missing for 9 per cent (n = 551) of the patients. Hospital observation and treatment were recommended for 5 per cent (n = 325) of the patients. This study highlights the necessity for poisoning prevention strategies to reduce the number of work-related incidents involving hazardous substances. The continuing increase in the number of workplace incidents involving hazardous substances is of concern. A comprehensive and multidisciplinary approach should be taken to gain a full understanding of occupational exposure to hazardous substances and to identify risk factors. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. An intravenous paracetamol overdose in an eight-day-old neonate

Author

NVIC, Circulatory Health, Medische Staf Intensive Care, NVIC bedrijfsvoering, Brain, Infection & Immunity, Koppen, Arjen, Bekkers, Cecile H J, Slabbers, Gordon H P R, de Lange, Dylan W, Verkooijen, Robbert B T, NVIC, Circulatory Health, Medische Staf Intensive Care, NVIC bedrijfsvoering, Brain, Infection & Immunity, Koppen, Arjen, Bekkers, Cecile H J, Slabbers, Gordon H P R, de Lange, Dylan W, and Verkooijen, Robbert B T

Published
2023

9. Significant Increase in Deliberate Self-Poisonings Among Adolescents During the Second Year of the COVID-19 Pandemic

Author

NVIC, Circulatory Health, NVIC bedrijfsvoering, Other research (not in main researchprogram), Medische Staf Intensive Care, Brain, Infection & Immunity, Koppen, Arjen, Thoonen, Ilze M J, Hunault, Claudine C, van Velzen, Agnes G, de Lange, Dylan W, Rietjens, Saskia J, NVIC, Circulatory Health, NVIC bedrijfsvoering, Other research (not in main researchprogram), Medische Staf Intensive Care, Brain, Infection & Immunity, Koppen, Arjen, Thoonen, Ilze M J, Hunault, Claudine C, van Velzen, Agnes G, de Lange, Dylan W, and Rietjens, Saskia J

Published
2023

10. Estimation of the risk of local and systemic effects in infants after ingestion of low-concentrated weak acids from descaling products

Author

Koppen, Arjen, Hunault, Claudine C, van Kleef, Regina G D M, van Velzen, Agnes G, Westerink, Remco H S, de Vries, Irma, de Lange, Dylan W, Koppen, Arjen, Hunault, Claudine C, van Kleef, Regina G D M, van Velzen, Agnes G, Westerink, Remco H S, de Vries, Irma, and de Lange, Dylan W

Abstract

INTRODUCTION: The accidental ingestion of diluted household descaling products by infants is a phenomenon that poison control centers regularly encounter. Feeding infants with baby milk prepared with water from electric kettles still containing descaler is a common way of exposure. This study aimed to determine the risks related to ingestion of (diluted) descalers by infants.METHODS: pH measurements were performed using acetic acid and three different commercially available electric kettle descalers. The pH of different dilutions was measured in the absence or presence of baby milk powder. In addition, an overview was made of pH values of different electric kettle descalers as given by the product information of the manufacturer. Finally, a simple pharmacokinetic (PK) model was used to predict changes in blood pH in infants after ingestion of acetic acid, which is the most commonly used descaler.RESULTS: Several commercially available electric kettle descalers have a pH <2. Even after diluting such descalers up to 10 times the pH can remain low. The addition of milk powder increases the pH of descalers containing weaker acids, with a pH >1.5, while descalers with stronger acids and pH <1 show little pH increase after the addition of milk powder. Finally, a simple PBPK model for the ingestion of acetic acid predicted that the ingestion of larger amounts of acetic acid (>1000 mg) by an infant could result in relevant changes in blood pH.CONCLUSIONS: Commercially available electric kettle descaling products may pose a health risk to infants in case of accidental ingestion since the pH of some of these products can be very low, even when diluted 10-times or in the presence of baby milk powder. Oral exposure of infants to the common descaler acetic acid, after accidental preparation of baby milk with cleaning vinegar, will probably not result in serious local effects, but changes in blood pH cannot be excluded when larger amounts of ac

Published
2022

11. Estimation of the risk of local and systemic effects in infants after ingestion of low-concentrated weak acids from descaling products

Author

One Health Toxicologie, IRAS OH Toxicology, dIRAS RA-1, Koppen, Arjen, Hunault, Claudine C, van Kleef, Regina G D M, van Velzen, Agnes G, Westerink, Remco H S, de Vries, Irma, de Lange, Dylan W, One Health Toxicologie, IRAS OH Toxicology, dIRAS RA-1, Koppen, Arjen, Hunault, Claudine C, van Kleef, Regina G D M, van Velzen, Agnes G, Westerink, Remco H S, de Vries, Irma, and de Lange, Dylan W

Published
2022

12. Lactic acidosis with elevated osmolal gap after ingestion of a lighter fluid containing dipropylene glycol monomethyl ether (DPGME), a case report

Author

NVIC bedrijfsvoering, Brain, Medische Staf Intensive Care, Infection & Immunity, NVIC, Circulatory Health, Langbroek, Pepijn M, Dreijer, Albert R, de Lange, Dylan W, Moorlag, Rosalie D, Passier, Martijn, van Leer, Bram, Koppen, Arjen, NVIC bedrijfsvoering, Brain, Medische Staf Intensive Care, Infection & Immunity, NVIC, Circulatory Health, Langbroek, Pepijn M, Dreijer, Albert R, de Lange, Dylan W, Moorlag, Rosalie D, Passier, Martijn, van Leer, Bram, and Koppen, Arjen

Published
2022

13. Clinical toxicology of exposures to chemicals from clandestine drug laboratories: a literature review

Author

NVIC, Circulatory Health, Medische Staf Intensive Care, NVIC bedrijfsvoering, Brain, Infection & Immunity, Koppen, Arjen, Wijnands-Kleukers, Anja P G, Gresnigt, Femke M J, de Lange, Dylan W, NVIC, Circulatory Health, Medische Staf Intensive Care, NVIC bedrijfsvoering, Brain, Infection & Immunity, Koppen, Arjen, Wijnands-Kleukers, Anja P G, Gresnigt, Femke M J, and de Lange, Dylan W

Published
2022

14. Estimation of the risk of local and systemic effects in infants after ingestion of low-concentrated weak acids from descaling products

Author

NVIC, Circulatory Health, Other research (not in main researchprogram), NVIC bedrijfsvoering, Medische Staf Intensive Care, Brain, Infection & Immunity, Koppen, Arjen, Hunault, Claudine C., van Kleef, Regina G.D.M., van Velzen, Agnes G., Westerink, Remco H.S., de Vries, Irma, de Lange, Dylan W., NVIC, Circulatory Health, Other research (not in main researchprogram), NVIC bedrijfsvoering, Medische Staf Intensive Care, Brain, Infection & Immunity, Koppen, Arjen, Hunault, Claudine C., van Kleef, Regina G.D.M., van Velzen, Agnes G., Westerink, Remco H.S., de Vries, Irma, and de Lange, Dylan W.

Published
2022

20. Natural killer T cells in adipose tissue prevent insulin resistance

Author

Schipper, Henk S., Rakhshandehroo, Maryam, van de Graaf, Stan F.J., Venken, Koen, Koppen, Arjen, Stienstra, Rinke, Prop, Serge, Meerding, Jenny, Hamers, Nicole, Besra, Gurdyal, Boon, Louis, Nieuwenhuis, Edward E.S., Elewaut, Dirk, Prakken, Berent, Kersten, Sander, Boes, Marianne, and Kalkhoven, Eric

Subjects
T cells -- Physiological aspects, Adipose tissues -- Physiological aspects, Insulin resistance -- Risk factors -- Prevention, Killer cells -- Physiological aspects, Health care industry
Abstract

Lipid overload and adipocyte dysfunction are key to the development of insulin resistance and can be induced by a high-fat diet. CD1d-restricted invariant natural killer T (iNKT) cells have been proposed as mediators between lipid overload and insulin resistance, but recent studies found decreased iNKT cell numbers and marginal effects of iNKT cell depletion on insulin resistance under high-fat diet conditions. Here, we focused on the role of iNKT cells under normal conditions. We showed that iNKT cell-deficient mice on a low-fat diet, considered a normal diet for mice, displayed a distinctive insulin resistance phenotype without overt adipose tissue inflammation. Insulin resistance was characterized by adipocyte dysfunction, including adipocyte hypertrophy, increased leptin, and decreased adiponectin levels. The lack of liver abnormalities in CD1d-null mice together with the enrichment of CD1d-restricted iNKT cells in both mouse and human adipose tissue indicated a specific role for adipose tissue-resident iNKT cells in the development of insulin resistance. Strikingly, iNKT cell function was directly modulated by adipocytes, which acted as lipid antigen-presenting cells in a CD1d-mediated fashion. Based on these findings, we propose that, especially under low-fat diet conditions, adipose tissue-resident iNKT cells maintain healthy adipose tissue through direct interplay with adipocytes and prevent insulin resistance., Introduction More than one-third of the U.S. population has insulin resistance, a condition that is predominantly caused by obesity and is associated with adipocyte dysfunction together with chronic low-grade adipose [...]

Published
2012
Full Text
View/download PDF

24. Profiling of 3696 nuclear receptor-coregulator interactions: A resource for biological and clinical discovery

Author

CMM Sectie Molecular Cancer Research, UMC Utrecht, Child Health, CMM Groep Kalkhoven, NVIC, Circulatory Health, CMM Groep Van Mil, Cancer, Broekema, Marjoleine F., Hollman, Danielle A.A., Koppen, Arjen, Van Den Ham, Henk Jan, Melchers, Diana, Pijnenburg, Dirk, Ruijtenbeek, Rob, Van Mil, Saskia W.C., Houtman, René, Kalkhoven, Eric, CMM Sectie Molecular Cancer Research, UMC Utrecht, Child Health, CMM Groep Kalkhoven, NVIC, Circulatory Health, CMM Groep Van Mil, Cancer, Broekema, Marjoleine F., Hollman, Danielle A.A., Koppen, Arjen, Van Den Ham, Henk Jan, Melchers, Diana, Pijnenburg, Dirk, Ruijtenbeek, Rob, Van Mil, Saskia W.C., Houtman, René, and Kalkhoven, Eric

Published
2018

26. Behandeling van intoxicatie met paracetamol : Rekening houden met dosis, toedienings vorm en risic ofact oren

Author

Koppen, Arjen, Van Riel, Antoinette J.H.P., Van Nugteren-Van Lonkhuyzen, Annette, and De Vries, Irma

Subjects
Medicine(all), organic chemicals, digestive, oral, and skin physiology
Abstract

Paracetamol is the drug for which the Dutch Poisons Information Centre (DPIC) receives the most information requests. The protocol for the treatment of single acute oral paracetamol intoxications is clear, however, ambiguity exists concerning the treatment of intoxications with repeated supratherapeutic doses of paracetamol. Paracetamol intoxications with liquid preparations, extendedrelease tablets, exposure routes other than oral, and repeated supratherapeutic ingestions require a tailored approach. An increased risk of liver damage due to paracetamol intoxication has to be taken into account for patients who consume excessive levels of alcohol, are malnourished or have a preexisting liver condition. The decision tree of the DPIC is a helpful tool to swiftly attain a risk assessment and treatment plan for most types of paracetamol intoxication. Conflict of interest and financial support: none declared.

Published
2017

31. Is it really safe to withhold folinic acid when less than 1000 mg/m(2) methotrexate is ingested?

Author

NVIC, Circulatory Health, Other research (not in main researchprogram), Medische Staf Intensive Care, Koppen, Arjen, Dijkman, Marieke A, Hunault, Claudine C, de Lange, Dylan W, de Vries, Irma, NVIC, Circulatory Health, Other research (not in main researchprogram), Medische Staf Intensive Care, Koppen, Arjen, Dijkman, Marieke A, Hunault, Claudine C, de Lange, Dylan W, and de Vries, Irma

Published
2017

34. Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colonocytes by selective PPARγ modulation

Author

Alex, Sheril, Lange, Katja, Amolo, Tom, Grinstead, Jeffrey S., Szalowska, Ewa, Koppen, Arjen, Mudde, Karin, Haenen, Danielle, Al-Lahham, S., Roelofsen, Han, Houtman, René, Burg, Bart, van den, Bonvin, Alexandre M., Kalkhoven, Eric, Muller, Michael, Hooiveld, Guido, Kersten, Sander, Alex, Sheril, Lange, Katja, Amolo, Tom, Grinstead, Jeffrey S., Szalowska, Ewa, Koppen, Arjen, Mudde, Karin, Haenen, Danielle, Al-Lahham, S., Roelofsen, Han, Houtman, René, Burg, Bart, van den, Bonvin, Alexandre M., Kalkhoven, Eric, Muller, Michael, Hooiveld, Guido, and Kersten, Sander

Abstract

Angiopoietin-like protein 4 (ANGPTL4, also referred to as Fiaf) has been proposed as a circulating mediator between the gut microbiota and fat storage in adipose tissue. Very little is known about the mechanisms of regulation of ANGPTL4 in the colon. Here we show that transcription and subsequent secretion of ANGPTL4 in human T84 and HT-29 colonocytes is highly induced by physiological concentrations of products of bacterial fermentation, the short-chain fatty acids. Short-chain fatty acids induce ANGPTL4 by activating the nuclear receptor PPARγ, as shown by microarray, transactivation assays, coactivator peptide recruitment assay, and use of PPARγ antagonist. At concentrations required for PPARγ activation and ANGPTL4 induction in colonocytes, SCFA do not stimulate PPARγ in mouse 3T3-L1 and human SGBS adipocytes, suggesting that SCFA act as selective PPARγ modulators (SPPARM), which is supported by coactivator peptide recruitment assay and structural modelling. It can be concluded that 1) SCFA potently stimulate ANGPTL4 synthesis in human colonocytes, and 2) SCFA transactivate and bind to PPARγ by serving as selective PPAR modulators. Our data point to activation of PPARγ as a novel mechanism of gene regulation by SCFA in the colon.

Published
2013

35. Short-Chain Fatty Acids Stimulate Angiopoietin-Like 4 Synthesis in Human Colon Adenocarcinoma Cells by Activating Peroxisome Proliferator-Activated Receptor gamma

Author

Sub NMR Spectroscopy, NMR Spectroscopy, Alex, Sheril, Lange, Katja, Amolo, Tom, Grinstead, Jeffrey S., Haakonsson, Anders K., Szalowska, Ewa, Koppen, Arjen, Mudde, Karin, Haenen, Danielle, Al-Lahham, Sa'ad, Roelofsen, Han, Houtman, Rene, van der Burg, Bart, Mandrup, Susanne, Bonvin, Alexandre M. J. J., Kalkhoven, Eric, Muller, Michael, Hooiveld, Guido J., Kersten, Sander, Sub NMR Spectroscopy, NMR Spectroscopy, Alex, Sheril, Lange, Katja, Amolo, Tom, Grinstead, Jeffrey S., Haakonsson, Anders K., Szalowska, Ewa, Koppen, Arjen, Mudde, Karin, Haenen, Danielle, Al-Lahham, Sa'ad, Roelofsen, Han, Houtman, Rene, van der Burg, Bart, Mandrup, Susanne, Bonvin, Alexandre M. J. J., Kalkhoven, Eric, Muller, Michael, Hooiveld, Guido J., and Kersten, Sander

Published
2013

36. CD1d-restricted NKT cell function prevents insulin resistance in lean mice, and is regulated by adipocytes and is regulated by adipocytes

Author

Schipper, Henk S., Rakhshandehroo, Maryam, van de Graaf, Stan F., Venken, Koen, Koppen, Arjen, Stienstra, Rinke, Prop, Serge, Meerding, Jenny, Hamers, Nicole, Besra, Gurdyal, Boon, Louis, Nieuwenhuis, Edward E., Elewaut, Dirk, Prakken, Berent, Kersten, Sander, Boes, Marianne, Kalkhoven, Eric, Schipper, Henk S., Rakhshandehroo, Maryam, van de Graaf, Stan F., Venken, Koen, Koppen, Arjen, Stienstra, Rinke, Prop, Serge, Meerding, Jenny, Hamers, Nicole, Besra, Gurdyal, Boon, Louis, Nieuwenhuis, Edward E., Elewaut, Dirk, Prakken, Berent, Kersten, Sander, Boes, Marianne, and Kalkhoven, Eric

Abstract

Lipid overload and adipocyte dysfunction are key to the development of insulin resistance and can be induced by a high-fat diet. CD1d-restricted invariant natural killer T (iNKT) cells have been proposed as mediators between lipid overload and insulin resistance, but recent studies found decreased iNKT cell numbers and marginal effects of iNKT cell depletion on insulin resistance under high-fat diet conditions. Here, we focused on the role of iNKT cells under normal conditions. We showed that iNKT cell–deficient mice on a low-fat diet, considered a normal diet for mice, displayed a distinctive insulin resistance phenotype without overt adipose tissue inflammation. Insulin resistance was characterized by adipocyte dysfunction, including adipocyte hypertrophy, increased leptin, and decreased adiponectin levels. The lack of liver abnormalities in CD1d-null mice together with the enrichment of CD1d-restricted iNKT cells in both mouse and human adipose tissue indicated a specific role for adipose tissue–resident iNKT cells in the development of insulin resistance. Strikingly, iNKT cell function was directly modulated by adipocytes, which acted as lipid antigen-presenting cells in a CD1d-mediated fashion. Based on these findings, we propose that, especially under low-fat diet conditions, adipose tissue–resident iNKT cells maintain healthy adipose tissue through direct interplay with adipocytes and prevent insulin resistance., Lipid overload and adipocyte dysfunction are key to the development of insulin resistance and can be induced by a high-fat diet. CD1d-restricted invariant natural killer T (iNKT) cells have been proposed as mediators between lipid overload and insulin resistance, but recent studies found decreased iNKT cell numbers and marginal effects of iNKT cell depletion on insulin resistance under high-fat diet conditions. Here, we focused on the role of iNKT cells under normal conditions. We showed that iNKT cell–deficient mice on a low-fat diet, considered a normal diet for mice, displayed a distinctive insulin resistance phenotype without overt adipose tissue inflammation. Insulin resistance was characterized by adipocyte dysfunction, including adipocyte hypertrophy, increased leptin, and decreased adiponectin levels. The lack of liver abnormalities in CD1d-null mice together with the enrichment of CD1d-restricted iNKT cells in both mouse and human adipose tissue indicated a specific role for adipose tissue–resident iNKT cells in the development of insulin resistance. Strikingly, iNKT cell function was directly modulated by adipocytes, which acted as lipid antigen-presenting cells in a CD1d-mediated fashion. Based on these findings, we propose that, especially under low-fat diet conditions, adipose tissue–resident iNKT cells maintain healthy adipose tissue through direct interplay with adipocytes and prevent insulin resistance.

Published
2012

37. Epidermis-type lipoxygenase 3 regulates adipocyte differentiation and peroxisome proliferator-activated receptor gamma activity

Author

Hallenborg, Philip, Jørgensen, Claus, Petersen, Rasmus K, Feddersen, Søren, Araujo, Pedro, Markt, Patrick, Langer, Thierry, Furstenberger, Gerhard, Krieg, Peter, Koppen, Arjen, Kalkhoven, Eric, Madsen, Lise, Kristiansen, Karsten, Hallenborg, Philip, Jørgensen, Claus, Petersen, Rasmus K, Feddersen, Søren, Araujo, Pedro, Markt, Patrick, Langer, Thierry, Furstenberger, Gerhard, Krieg, Peter, Koppen, Arjen, Kalkhoven, Eric, Madsen, Lise, and Kristiansen, Karsten

Abstract

Udgivelsesdato: 2010-Aug, The nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR gamma) is essential for adipogenesis. Although several fatty acids and their derivatives are known to bind and activate PPAR gamma, the nature of the endogenous ligand(s) promoting the early stages of adipocyte differentiation has remained enigmatic. Previously, we showed that lipoxygenase (LOX) activity is involved in activation of PPAR gamma during the early stages of adipocyte differentiation. Of the seven known murine LOXs, only the unconventional LOX epidermis-type lipoxygenase 3 (eLOX3) is expressed in 3T3-L1 preadipocytes. Here, we show that forced expression of eLOX3 or addition of eLOX3 products stimulated adipogenesis under conditions that normally require an exogenous PPAR gamma ligand for differentiation. Hepoxilins, a group of oxidized arachidonic acid derivatives produced by eLOX3, bound to and activated PPAR gamma. Production of hepoxilins was increased transiently during the initial stages of adipogenesis. Furthermore, small interfering RNA-mediated or retroviral short hairpin RNA-mediated knockdown of eLOX3 expression abolished differentiation of 3T3-L1 preadipocytes. Finally, we demonstrate that xanthine oxidoreductase (XOR) and eLOX3 synergistically enhanced PPAR gamma-mediated transactivation. Collectively, our results indicate that hepoxilins produced by the concerted action of XOR and eLOX3 may function as PPAR gamma activators capable of promoting the early PPAR gamma-dependent steps in the conversion of preadipocytes into adipocytes.

Published
2010

38. Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60

Author

Gao, Yuan, primary, Koppen, Arjen, additional, Rakhshandehroo, Maryam, additional, Tasdelen, Ismayil, additional, van de Graaf, Stan F., additional, van Loosdregt, Jorg, additional, van Beekum, Olivier, additional, Hamers, Nicole, additional, van Leenen, Dik, additional, Berkers, Celia R., additional, Berger, Ruud, additional, Holstege, Frank C.P., additional, Coffer, Paul J., additional, Brenkman, Arjan B., additional, Ovaa, Huib, additional, and Kalkhoven, Eric, additional

Published
2013
Full Text
View/download PDF

39. Short-Chain Fatty Acids Stimulate Angiopoietin-Like 4 Synthesis in Human Colon Adenocarcinoma Cells by Activating Peroxisome Proliferator-Activated Receptor γ

Author

Alex, Sheril, primary, Lange, Katja, additional, Amolo, Tom, additional, Grinstead, Jeffrey S., additional, Haakonsson, Anders K., additional, Szalowska, Ewa, additional, Koppen, Arjen, additional, Mudde, Karin, additional, Haenen, Daniëlle, additional, Al-Lahham, Sa'ad, additional, Roelofsen, Han, additional, Houtman, René, additional, van der Burg, Bart, additional, Mandrup, Susanne, additional, Bonvin, Alexandre M. J. J., additional, Kalkhoven, Eric, additional, Müller, Michael, additional, Hooiveld, Guido J., additional, and Kersten, Sander, additional

Published
2013
Full Text
View/download PDF

40. Pmch-Deficiency in Rats Is Associated with Normal Adipocyte Differentiation and Lower Sympathetic Adipose Drive

Author

Mul, Joram D., primary, O’Duibhir, Eoghan, additional, Shrestha, Yogendra B., additional, Koppen, Arjen, additional, Vargoviç, Peter, additional, Toonen, Pim W., additional, Zarebidaki, Eleen, additional, Kvetnansky, Richard, additional, Kalkhoven, Eric, additional, Cuppen, Edwin, additional, and Bartness, Timothy J., additional

Published
2013
Full Text
View/download PDF

44. Epidermis-Type Lipoxygenase 3 Regulates Adipocyte Differentiation and Peroxisome Proliferator-Activated Receptor γ Activity

Author

Hallenborg, Philip, primary, Jørgensen, Claus, additional, Petersen, Rasmus K., additional, Feddersen, Søren, additional, Araujo, Pedro, additional, Markt, Patrick, additional, Langer, Thierry, additional, Furstenberger, Gerhard, additional, Krieg, Peter, additional, Koppen, Arjen, additional, Kalkhoven, Eric, additional, Madsen, Lise, additional, and Kristiansen, Karsten, additional

Published
2010
Full Text
View/download PDF

50. Pmch-Deficiency in Rats Is Associated with Normal Adipocyte Differentiation and Lower Sympathetic Adipose Drive.

Author

Mul, Joram D., O’Duibhir, Eoghan, Shrestha, Yogendra B., Koppen, Arjen, Vargoviç, Peter, Toonen, Pim W., Zarebidaki, Eleen, Kvetnansky, Richard, Kalkhoven, Eric, Cuppen, Edwin, and Bartness, Timothy J.

Subjects
APPETITE stimulants, NEUROPEPTIDES, LABORATORY rats, FAT cells, CELL differentiation, MELANIN-concentrating hormone, HYPOTHALAMUS
Abstract

The orexigenic neuropeptide melanin-concentrating hormone (MCH), a product of Pmch, is an important mediator of energy homeostasis. Pmch-deficient rodents are lean and smaller, characterized by lower food intake, body-, and fat mass. Pmch is expressed in hypothalamic neurons that ultimately are components in the sympathetic nervous system (SNS) drive to white and interscapular brown adipose tissue (WAT, iBAT, respectively). MCH binds to MCH receptor 1 (MCH1R), which is present on adipocytes. Currently it is unknown if Pmch-ablation changes adipocyte differentiation or sympathetic adipose drive. Using Pmch-deficient and wild-type rats on a standard low-fat diet, we analyzed dorsal subcutaneous and perirenal WAT mass and adipocyte morphology (size and number) throughout development, and indices of sympathetic activation in WAT and iBAT during adulthood. Moreover, using an in vitro approach we investigated the ability of MCH to modulate 3T3-L1 adipocyte differentiation. Pmch-deficiency decreased dorsal subcutaneous and perirenal WAT mass by reducing adipocyte size, but not number. In line with this, in vitro 3T3-L1 adipocyte differentiation was unaffected by MCH. Finally, adult Pmch-deficient rats had lower norepinephrine turnover (an index of sympathetic adipose drive) in WAT and iBAT than wild-type rats. Collectively, our data indicate that MCH/MCH1R-pathway does not modify adipocyte differentiation, whereas Pmch-deficiency in laboratory rats lowers adiposity throughout development and sympathetic adipose drive during adulthood. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results