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11. Journey II BCS has a lower revision rates than journey I

Author

Christen, B and Kopjar, B

Subjects
ddc: 610, Journey II, reoperation, comparisons, Revision rates, 610 Medical sciences, Medicine, Journey I
Abstract

Objectives: Aim of this study was to compare early reoperation and revision rate of Journey II bi-cruciate stabilized (BCS) total knee system (TKS) and Journey I BCS TKS. Methods: We conducted a retrospective longitudinal non-concurrent cohort study of 141 Journey II TKAs (average follow-up duration[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2017)

Published
2017
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13. C.02 Predictors of survival in a surgical series of Metastatic Spinal Cord Compression and a complete external validation of 8 models in a prospective multi-centre study

Author

Nater, A, primary, Tetreault, LA, additional, Kopjar, B, additional, Arnold, PM, additional, Dekutoski, MB, additional, Finkelstein, JA, additional, Fisher, CG, additional, France, JC, additional, Gokaslan, ZL, additional, Rhines, LD, additional, Rose, PS, additional, Sahgal, A, additional, Schuster, JM, additional, Vaccaro, AR, additional, and Fehlings, MG, additional

Published
2018
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14. Improving sleep for patients with restless legs syndrome. Part II: meta-analysis of vibration therapy and drugs approved by the FDA for treatment of restless legs syndrome

Author

Burbank F, Buchfuhrer MJ, and Kopjar B

Subjects
mental disorders, lcsh:Neurology. Diseases of the nervous system, lcsh:RC346-429
Abstract

Fred Burbank,1 Mark J Buchfuhrer,2 Branko Kopjar3 1Salt Creek International Women's Health Foundation, San Clemente, CA, 2Stanford University Center for Sleep Sciences, Downey, CA, 3Department of Health Services, University of Washington, Seattle, WA, USA Background: Vibratory stimulation pads have been shown to improve sleep in patients with restless legs syndrome (RLS) to a greater extent than sham therapy. The current gold standard of treatment is drugs approved by the US Food and Drug Administration (FDA) for use in RLS. The aim of this meta-analysis was to compare the efficacy and safety of vibratory stimulation pads, sham pads, and drugs approved by the FDA for use in RLS. Methods: We searched the PubMed, Embase, and clinical trial websites to identify the relevant randomized, double-blind, and placebo-controlled or sham-controlled studies. Fifteen studies including a combined total of 3455 patients with at least moderately severe primary RLS met our search criteria. Efficacy was defined as the standardized mean difference in sleep improvement between treatment and controls. Safety was assessed by comparing the odds ratios of any adverse events and adverse events leading to study withdrawal between treatment and control subjects. Results: Improvement in Medical Outcomes Study (MOS) sleep inventory scores from baseline was significantly greater in patients treated with vibratory stimulation pads than in those receiving sham pads (Hedges's g, standardized mean difference −0.39, P ≤ 0.02). There was no difference in improvement in sleep scores between patients treated with vibratory stimulation pads (−0.39) and those receiving an approved RLS drug (−0.44, P > 0.70). The risk of any adverse event or withdrawal because of an adverse event was not significantly different between patients treated with vibratory stimulation pads and those assigned to sham pads (Mantel-Haenszel odds ratio 2.16 [P > 0.14] and 1.39 [P > 0.80], respectively). The odds ratios for patients reporting any adverse events and adverse events leading to withdrawal were not significantly different between patients treated with vibratory stimulation pads (2.16 and 1.39, respectively) and those who received approved RLS drugs (2.11 [P > 0.89] and 2.07 [P > 0.82], respectively, mixed-effects model). Conclusion: For patients with moderately severe RLS, vibratory stimulation pads were more effective than sham pads for improving sleep, as effective as FDA-approved RLS drugs, and as safe as both sham pads and FDA-approved RLS drugs. Keywords: meta-analysis, restless legs syndrome, sleep, vibration, counterstimulation, drug therapy

Published
2013

15. Sleep improvement for restless legs syndrome patients. Part I: pooled analysis of two prospective, double-blind, sham-controlled, multi-center, randomized clinical studies of the effects of vibrating pads on RLS symptoms

Author

Burbank F, Buchfuhrer MJ, and Kopjar B

Subjects
body regions, lcsh:Neurology. Diseases of the nervous system, lcsh:RC346-429
Abstract

Fred Burbank,1 Mark J Buchfuhrer,2 Branko Kopjar31Salt Creek International Women’s Health Foundation, San Clemente, CA, USA; 2Stanford University Center for Sleep Sciences, Downey, CA, USA; 3Department of Health Services, University of Washington, Seattle, WA, USAPurpose: Pooled data from two randomized, double-blind, prospective clinical trials were analyzed (i) to determine if vibratory stimulation can safely treat patients with moderately severe restless legs syndrome and (ii) to compare two types of shams.Patients and methods: One hundred and fifty-eight patients with at least moderately severe primary restless legs syndrome (a score of 15 or greater on the International Restless Legs Syndrome Study Group rating scale) were enrolled at five investigational sites, between April 20, 2009 and February 12, 2010. Patients were randomly assigned to treatment with a vibrating pad or control (sound-producing or light-emitting sham pad). Patients and investigators were blinded to pad assignment type (treatment pad or sham pad). Efficacy was measured as a change in score from baseline to week 4, on the Medical Outcomes Study Sleep Problems Index II, the Johns Hopkins Restless Legs Syndrome Quality of Life summary scale, and the International Restless Legs Syndrome Study Group rating scale. Clinicians were asked to evaluate the effectiveness of the pad assignment and to guess whether treatment or sham therapy had been assigned. Adverse events related to vibrating pad assignment were tabulated.Results: The Medical Outcomes Study Sleep Problems Index II scores improved significantly more for patients receiving a vibrating pad over those receiving a sham pad (P ≤ 0.02) even when corrected for multiplicity (P ≤ 0.04). Clinician evaluation favored patients assigned vibrating pads, and neither patients nor clinicians accurately guessed which pad was assigned. No significant difference in adverse event rates was observed between the vibrating and sham pad groups. Sound and light sham pads performed comparably with respect to safety and efficacy.Conclusion: Four weeks of treatment with vibrating pads safely improved sleep in patients with restless legs syndrome and both shams functioned comparably.Keywords: restless legs syndrome, vibration therapy, sham-controlled, double-blind, randomized clinical trial

Published
2013

16. The modified Japanese Orthopaedic Association scale: establishing criteria for mild, moderate and severe impairment in patients with degenerative cervical myelopathy

Author

Tetreault, L., Kopjar, B., Nouri, A., Arnold, P., Barbagallo, G., Bartels, R.H.M.A., Qiang, Z., Singh, A., Zileli, M., Vaccaro, A., Fehlings, M.G., Tetreault, L., Kopjar, B., Nouri, A., Arnold, P., Barbagallo, G., Bartels, R.H.M.A., Qiang, Z., Singh, A., Zileli, M., Vaccaro, A., and Fehlings, M.G.

Abstract

Item does not contain fulltext, PURPOSE: We aimed to determine cut-offs between mild, moderate and severe myelopathy on the modified Japanese Orthopedic Association (mJOA) score. METHODS: Between December 2005 and January 2011, 757 patients with clinically diagnosed DCM were enrolled in the prospective AOSpine North America (n = 278) or International (n = 479) study at 26 sites. Functional status and quality of life were evaluated at baseline using a variety of outcome measures. Using the Nurick score as an anchor, receiver operating curve (ROC) analysis was conducted to determine cut-offs between mild, moderate and severe disease. The validity of the identified cut-offs was evaluated by examining whether patients in different severity groups differed in terms of impairment, disability, quality of life and number of signs and symptoms. RESULTS: A mJOA of 14 was determined to be the cut-off between mild and moderate myelopathy and a mJOA of 11 was the cut-off score between moderate and severe disease. Patients in the severe myelopathy group (n = 254) had significantly reduced quality of life and functional status and a greater number of signs and symptoms compared to patients classified as mild (n = 190) or moderate (n = 296). CONCLUSIONS: Mild myelopathy can be defined as mJOA from 15 to 17, moderate as mJOA from 12 to 14 and severe as mJOA from 0 to 11. These categories should be adopted worldwide to standardize clinical assessment of DCM.

Published
2017

17. Does age affect surgical outcomes in patients with degenerative cervical myelopathy? Results from the prospective multicenter AOSpine International study on 479 patients

Author

Nakashima, H., Tetreault, L.A., Nagoshi, N., Nouri, A., Kopjar, B., Arnold, P.M., Bartels, R.H.M.A., Defino, H., Kale, S., Zhou, Q., Fehlings, M.G., Nakashima, H., Tetreault, L.A., Nagoshi, N., Nouri, A., Kopjar, B., Arnold, P.M., Bartels, R.H.M.A., Defino, H., Kale, S., Zhou, Q., and Fehlings, M.G.

Abstract

Contains fulltext : 172337.pdf (Publisher’s version ) (Open Access), BACKGROUND: In general, older patients with degenerative cervical myelopathy (DCM) are felt to have lower recovery potential following surgery due to increased degenerative pathology, comorbidities, reduced physiological reserves and age-related changes to the spinal cord. This study aims to determine whether age truly is an independent predictor of surgical outcome and to provide evidence to guide practice and decision-making. METHODS: A total of 479 patients with DCM were prospectively enrolled in the CSM-International study at 16 centres. Our sample was divided into a younger group (<65 years) and an elderly (>/=65 years) group. A mixed model analytic approach was used to evaluate differences in the modified Japanese Orthopaedic Association (mJOA), Nurick, Short Form-36 (SF-36) and Neck Disability Index (NDI) scores between groups. We first created an unadjusted model between age and surgical outcome and then developed two adjusted models that accounted for variations in (1) baseline characteristics and (2) both baseline and surgical factors. RESULTS: Of the 479 patients, 360 (75.16%) were <65 years and 119 (24.84%) were >/=65 years. Elderly patients had a worse preoperative health status (p<0.0001) and were functionally more severe (p<0.0001). The majority of younger patients (64.96%) underwent anterior surgery, whereas the preferred approach in the elderly group was posterior (58.62%, p<0.0001). Elderly patients had a greater number of decompressed levels than younger patients (p<0.0001). At 24 months after surgery, younger patients achieved a higher postoperative mJOA (p<0.0001) and a lower Nurick score (p<0.0001) than elderly patients. After adjustments for patient and surgical characteristics, these differences in postoperative outcome scores decreased but remained significant. CONCLUSIONS: Older age is an independent predictor of functional status in patients with DCM. However, patients over 65 with DCM still achieve functionally significant improvement aft

Published
2016

18. A Global Perspective on the Outcomes of Surgical Decompression in Patients With Cervical Spondylotic Myelopathy: Results From the Prospective Multicenter AOSpine International Study on 479 Patients

Author

Fehlings, M.G., Ibrahim, A., Tetreault, L., Albanese, V., Alvarado, M., Arnold, P., Barbagallo, G., Bartels, R.H.M.A., Bolger, C., Defino, H., Kale, S., Massicotte, E., Moraes, O., Scerrati, M., Tan, G., Tanaka, M., Toyone, T., Yukawa, Y., Zhou, Q., Zileli, M., Kopjar, B., Fehlings, M.G., Ibrahim, A., Tetreault, L., Albanese, V., Alvarado, M., Arnold, P., Barbagallo, G., Bartels, R.H.M.A., Bolger, C., Defino, H., Kale, S., Massicotte, E., Moraes, O., Scerrati, M., Tan, G., Tanaka, M., Toyone, T., Yukawa, Y., Zhou, Q., Zileli, M., and Kopjar, B.

Abstract

Item does not contain fulltext, STUDY DESIGN: Prospective, multicenter international cohort. OBJECTIVE: To evaluate outcomes of surgical decompression for cervical spondylotic myelopathy (CSM) at a global level. SUMMARY OF BACKGROUND DATA: CSM is a degenerative spine disease and the most common cause of spinal cord dysfunction worldwide. Surgery is increasingly recommended as the preferred treatment strategy for CSM to improve neurological and functional status and quality of life. The outcomes of surgical intervention for CSM have never been evaluated at an international level. METHODS: Between October 2007 and January 2011, 479 symptomatic patients with image evidence of CSM were enrolled in the prospective, multicenter AOSpine CSM-International study from 16 global sites. Preoperative and postoperative clinical status, functional impairment, and quality of life were evaluated using the modified Japanese Orthopaedic Assessment Scale, Nurick Scale, Neck Disability Index, and Short-Form-36v2. Preoperative and 12- and 24-month postoperative outcomes were compared using mixed-model analysis of covariance for repeated measurements. RESULTS: The study cohort consisted of 310 males and 169 females, with a mean age of 56.37 +/- 11.91 years. There were significant differences in age, etiology, and surgical approaches between the regions. At 24 months postoperatively, the mean modified Japanese Orthopaedic Assessment Scale score improved from 12.50 (95% confidence interval [CI], 12.24-12.76) to 14.90 (95% CI, 14.64-15.16); the Neck Disability Index improved from 36.38 (95% CI, 34.33-38.43) to 23.20 (95% CI, 21.24-25.15); and the SF36v2 Physical Component Score and Mental Composite Score improved from 34.28 (95% CI, 33.46-35.10) to 40.76 (95% CI, 39.71-41.81) and 39.45 (95% CI, 38.25-40.64) to 46.24 (95% CI, 44.94-47.55), respectively. The rate of neurological complications was 3.13%. CONCLUSION: Surgical decompression for CSM is safe and results in improved functional status and quality of life in patient

Published
2015

19. 133 International Variations in the Clinical Presentation and Management of Cervical Spondylotic Myelopathy: One-Year Outcomes of the AOSpine Multicenter Prospective CSM-I Study

Author

Fehlings, M.G., Kopjar, B., Kale, S.S., Defino, H., Barbagallo, G., Bartels, R.H.M.A., Zhou, Q., Arnold, P.M., Zileli, M., Tan, G., Moraes, O., Yukawa, Y., Alvarado, M., Scerrati, M., Toyone, T., Tanaka, M., and Bolger, C.

Subjects
Evaluation of complex medical interventions Aetiology, screening and detection [NCEBP 2]
Abstract

Item does not contain fulltext INTRODUCTION: : While cervical spondylotic myelopathy (CSM) is the most common cause of spinal cord impairment worldwide, little is known regarding international variations in clinical presentation, management and outcomes of this condition. To address this key issue, we undertook a prospective multicenter study of CSM patients undergoing surgical treatment. METHODS: : 486 patients with clinically symptomatic CSM were enrolled in 16 sites in Europe, Asia, North and South America. The following outcomes were assessed: modified Japanese Orthopaedic Assessment scale (mJOA), Nurick Score, Neck Disability Index (NDI), short form 36v2, and complications. Data were analyzed using multivariate techniques (SAS 9.2) adjusting for baseline differences in patient populations (age, gender, surgical approach, number of spinal levels and baseline outcome parameter value). RESULTS: : To date, 389 patients have completed the 1-year follow-up. Thirty-five percent were females with an average age of 56.2 yrs (SD 12.4). Patients underwent anterior (58%), posterior (40%) or circumferential (2%) surgery. There were significant differences in the age at presentation and baseline neurological status among the regions, with Asian and Latin American patients being significantly younger and with less neurological impairment. With surgical treatment, there was a significant (P < 0.001) improvement from baseline values to 12 months in all outcome parameters assessed. The amount of improvement varied across the international regions with patients from Asia-Pacific and Latin America reporting comparatively better SF36 PCS and MCS scores for comparatively similar outcomes on the Nurick and mJOA assessments. CONCLUSION: : This large prospective global clinical study shows that surgical treatment for CSM is associated with significant improvements in generic and patient-specific outcome measures at one-year. Interestingly, there are significant variations in clinical presentation and in patient perceptions of the impact of these improvements on their perceptions of quality of life. 01 augustus 2012

Published
2012

27. Immunological status and respiratory findings in furriers

Author

Schachter En, L Stilinović, Eugenija Zuskin, Kopjar B, and Kanceljak B

Subjects
Adult, medicine.medical_specialty, Allergy, Physiology, Animal Population Groups, Pulmonary function testing, Cohort Studies, Atopy, Occupational Exposure, biology.animal, Epidemiology, Respiratory Hypersensitivity, medicine, Animals, Humans, Respiratory system, Mink, Skin Tests, biology, business.industry, Respiratory disease, Public Health, Environmental and Occupational Health, Middle Aged, medicine.disease, Occupational Diseases, Acute Disease, Chronic Disease, Immunology, Female, business, Hair, Cohort study
Abstract

We studied 42 women occupationally exposed in the fur manufacturing industry (mean age: 34 years, mean duration of exposure: 11 years). The highest prevalence of positive immediate skin reactions to antigen of animal hair was found for marten (10%), followed by fox and lamb (7%), mink (5%), and Chinese lamb, domestic fox, and Chinese calf (2%). Precipitating antibodies were demonstrated for lamb (17%), astrakhan (14%), mink, domestic fox and skunk (12%), Chinese lamb (10%), and Chinese calf (7%). Increased total IgE was found in 9.5% of subjects. Chronic symptoms were consistently more prevalent among workers with positive skin tests and positive precipitins than among workers with negative tests. A high prevalence of acute symptoms during the work shift was found among furriers. The prevalence of these symptoms was higher among workers with positive precipitating antibodies than among those with negative studies but not for workers with positive skin tests. Mean acute reductions in ventilatory capacity over the work shift were recorded for most ventilatory parameters. In general, greater drops in respiratory parameters occurred in individuals with positive precipitins (e.g., FEV1: -6.5% vs. -2.8%; positive vs. negative precipitins) but not in those with positive skin tests. Our study suggests that workers in the fur manufacturing industry develop acute and chronic respiratory problems often associated with specific indicators of atopy.

Published
1992

29. Combined Spine Conference of the Canadian Spine Society New Zealand Orthopaedic Spine Society, Spine Society of Australia: Fairmont Château Lake Louise, Lake, Louise, Alberta, Tuesday, Feb. 25 to Saturday, Mar. 1, 20141.1.01 The use of suspension radiographs to predict LIV tilt.1.1.02 Surgical correction of adolescent idiopathic scoliosis without fusion: an animal model.1.1.03 Are full torso surface topography postural measurements more sensitive to change than back only parameters in adolescents with idiopathic scoliosis and a main thoracic curve?1.2.04 Restoration of thoracic kyphosis in adolescent idiopathic kyphosis: comparative radiographic analysis of round versus rail rods.1.2.05 Scoliosis surgery in spastic quadriplegic cerebral palsy: Is fusion to the pelvis always necessary? A 4–18-year follow-up study.1.2.06 Identification and validation of pain-related biomarkers surrounding spinal surgery in adolescents.1.3.07 Cervical sagittal deformity develops after PJK in adult throacolumbar deformity correction: radiographic analysis using a novel global sagittal angular parameter, the CTPA.1.3.08 Impact of obesity on complications and patient-reported outcomes in adult spinal deformity surgery.1.3.09 The T1 pelvic angle, a novel radiographic measure of sagittal deformity, accounts for both pelvic retroversion and truncal inclination and correlates strongly with HRQOL.1.4.10 Determining cervical sagittal deformity when it is concurrent with thoracolumbar deformity.1.4.11 The influence of sagittal balance and pelvic parameters on the outcome of surgically treated patients with degenerative spondylolisthesis.1.4.12 Predictors of degenerative spondylolisthesis and loading translation in surgical lumbar spinal stenosis patients.2.1.13 Mechanical allodynia following disc herniation requires intraneural macrophage infiltration and can be blocked by systemic selenium delivery or attenuation of BDNF activity.2.1.14 The effect of alanyl-glutamine on epidural fibrosis in a rat laminectomy model.2.1.15 Anterior lumbar interbody fusion using recombinant human bone morphogenetic protein-2: a prospective study of complications.2.2.16 2-year results of a Canadian, multicentre, blinded, pilot study of a novel peptide in promoting lumbar spine fusion.2.2.17 Comparative outcomes and cost-utility following surgical treatment of focal lumbar spinal stenosis compared with osteoarthritis of the hip or knee: long-term change in health-related quality of life.2.2.18 Changes in objectively measured walking performance, function, and pain following surgery for spondylolisthesis and lumbar spinal stenosis.2.3.19 A prospective multicentre observational data-monitored study of minimally invasive fusion to treat degenerative lumbar disorders: complications and outcomes at 1-year follow-up.2.3.20 Assessment and classification of subsidence in lateral interbody fusion using serial computed tomography.2.3.21 Predictors of willingness to undergo spinal and orthopaedic surgery after surgical consultation.2.4.22 Indirect foraminal decompression is independent of facet arthropathy in extreme lateral interbody fusion.2.4.23 Cervical artificial disc replacement with ProDisc-C: clinical and radiographic outcomes with long-term follow-up.2.4.24 Tantalum trabecular metal implants in anterior cervical corpectomy and fusion.3.1.25 Hemangiomas of the spine: results of surgical management and prognostic variables for local recurrence and mortality in a multicentre study.3.1.26 Chondrosarcomas of the spine: prognostic variables for local recurrence and mortality in a multicentre study.3.1.27 Risk factors for recurrence of surgically treated spine schwannomas: analysis of 169 patients from a multicentre international database.3.2.28 Survival pattern and the effect of surgery on health related quality of life and functional outcome in patients with metastatic epidural spinal cord compression from lung cancer — the AOSpine North America prospective multicentre study.3.2.29 A biomechanical assessment of kyphoplasty as a stand-alone treatment in a human cadaveric burst fracture model.3.2.30 What is safer in incompetent vertebrae with posterior wall defects, kyphoplasty or vertebroplasty: a study in vertebral analogs.3.3.31 Feasibility of recruiting subjects for acute spinal cord injury (SCI) clinical trials in Canada.3.3.32 Prospective analysis of adverse events in elderly patients with traumatic spinal cord injury.3.3.33 Does traction before surgery influence time to neural decompression in patients with spinal cord injury?3.4.34 Current treatment of individuals with traumatic spinal cord injury: Do we need age-specific guidelines?3.4.35 Current surgical practice for traumatic spinal cord injury in Canada.3.4.36 The importance of “time to surgery” for traumatic spinal cord injured patients: results from an ambispective Canadian cohort of 949 patients.3.5.37 Assessment of a novel coil-shaped radiofrequency probe in the porcine spine.3.5.38 The effect of norepinephrine and dopamine on cerebrospinal fluid pressure after acute spinal cord injury.3.5.39 The learning curve of pedicle screw placement: How many screws are enough?4.1.40 Preliminary report from the Ontario Inter-professional Spine Assessment and Education Clinics (ISAEC).4.1.41 A surrogate model of the spinal cord complex for simulating bony impingement.4.1.42 Clinical and surgical predictors of specific complications following surgery for the treatment of degenerative cervical myelopathy: results from the multicentre, prospective AOSpine international study on 479 patients.4.2.43 Outcomes of surgical management of cervical spondylotic myelopathy: results of the prospective, multicentre, AOSpine international study in 479 patients.4.2.44 A clinical prediction rule for clinical outcomes in patients undergoing surgery for degenerative cervical myelopathy: analysis of an international AOSpine prospective multicentre data set of 757 subjects.4.2.45 The prevalence and impact of low back and leg pain among aging Canadians: a cross-sectional survey.4.3.46 Adjacent segment pathology: Progressive disease course or a product of iatrogenic fusion?4.3.47 Natural history of degenerative lumbar spondylolisthesis in patients with spinal stenosis.4.3.48 Changes in self-reported clinical status and health care utilization during wait time for surgical spine consultation: a prospective observational study.4.3.49 The Canadian surgical wait list for lumbar degenerative spinal stenosis has a detrimental effect on patient outcomes.4.3.50 Segmental lordosis is independent of interbody cage position in XLIF.4.3.51 Elevated patient BMI does not negatively affect self-reported outcomes of thoracolumbar surgery.1.5.52 The Spinal Stenosis Pedometer and Nutrition Lifestyle Intervention (SSPANLI): development and pilot.1.5.53 Study evaluating the variability of surgical strategy planning for patients with adult spinal deformity.1.5.54 Atlantoaxial instability in acute odontoid fractures is associated with nonunion and mortality.1.5.55 Peripheral hypersensitivity to subthreshold stimuli persists after resolution of acute experimental disc-herniation neuropathy.1.5.56 Radiation induced lumbar spinal osteonecrosis: case report and literature review.1.5.57 Comparative outcomes and cost-utility following surgical treatment of focal lumbar spinal stenosis compared with osteoarthritis of the hip or knee: Part 2 — estimated lifetime incremental cost-utility ratios.1.5.58 A predictive model of progression for adolescent idiopathic scoliosis based on 3D spine parameters at first visit.1.5.59 Development of a clinical prediction model for surgical decision making in patients with degenerative lumbar spine disease.2.5.60 Canadian spine surgery fellowship education: evaluating opportunity in developing a nationally based training curriculum.2.5.61 Pedicle subtraction osteotomy for severe proximal thoracic junctional kyphosis.2.5.62 A comparison of spine surgery referrals triaged through a multidisciplinary care pathway versus conventional referrals.2.5.63 Results and complications of posterior-based 3 column osteotomies in patients with previously fused spinal deformities.2.5.64 Orthopaedic Surgical AdVerse Event Severity (Ortho-SAVES) system: identifying opportunities for improved patient safety and resource utilization.2.5.65 Spontaneous spinal extra-axial haematomas — surgical experience in Otago and Southland 2011–2013.2.5.66 Obesity and spinal epidural lipomatosis in cauda equina syndrome.2.5.67 Factors affecting restoration of lumbar lordosis in adult degenerative scoliosis patients treated with lateral trans-psoas interbody fusion.3.6.68 Systematic review of complications in spinal surgery: a comparison of retrospective and prospective study design.3.6.69 Postsurgical rehabilitation patients have similar fear avoidance behaviour levels as those in nonoperative care.3.6.70 Outcomes of surgical treatment of adolescent spondyloptosis: a case series.3.6.71 Surgical success in primary versus revision thoracolumbar spine surgery.3.6.72 The effect of smoking on subjective patient outcomes in thoracolumbar surgery.3.6.73 Modelling patient recovery to predict outcomes following elective thoracolumbar surgery for degenerative pathologies.3.6.74 Outcomes from trans-psoas versus open approaches in the treatment of adult degenerative scoliosis.3.6.75 Lumbar spinal stenosis and presurgical assessment: the impact of walking induced strain on a performance-based outcome measure.

Author

van West, H., primary, Hodgson, B., primary, Parent, E., primary, Samuel, S., primary, Ferland, C., primary, Soroceanu, A., primary, Protopsaltis, T., primary, Radovanovic, I., primary, Amritanand, R., primary, Shamji, M., primary, Haugo, K., primary, Malham, G., primary, Jarzem, P., primary, Rampersaud, Y.R., primary, Tomkins-Lane, C., primary, Manson, N., primary, King, V., primary, Goldstein, C., primary, Fisher, C., primary, Fehlings, M., primary, Wong, E., primary, Sardar, Z., primary, Christie, S.D., primary, Patel, A., primary, Pinkoski, C., primary, Ahn, H., primary, Drew, B., primary, Dvorak, M., primary, Pezeshki, P., primary, Altaf, F., primary, Wilde, P., primary, Sparrey, C., primary, Tetreault, L., primary, Rampersaud, R., primary, Jack, A., primary, Johnstone, R., primary, Fernandes, A., primary, Urquhart, J., primary, Morokoff, A., primary, Manson, N.A., primary, Phan, P., primary, Evaniew, N., primary, Manson, J., primary, Nault, M.-L., primary, St-Pierre, G. Hardy, primary, Larouche, J., primary, Lewis, S., primary, Wilgenbusch, C., primary, Johnson, R., primary, Cushnie, D., primary, Sridharan, S., primary, Street, J., primary, Gregg, C., primary, Missiuna, P., primary, Abraham, E.P., primary, Huang, E., primary, Passmore, S., primary, Mac-Thiong, J.-M., additional, Labelle, H., additional, Moulin, D., additional, Turgeon, I., additional, Roy-Beaudry, M., additional, Bourassa, N., additional, Petit, Y., additional, Parent., S., additional, Chabot, S., additional, Westover, L., additional, Hill, D., additional, Moreau, M., additional, Hedden, D., additional, Lou, E., additional, Adeeb., S., additional, Smith, M., additional, Bridge, C., additional, Hsu, B., additional, Gray., R., additional, Group, PORSCHE Study, additional, Saran, N., additional, Stone, L., additional, Ouellet., J., additional, Protopsaltis, T., additional, Terran, J., additional, Bronsard, N., additional, Smith, J., additional, Klineberg, E., additional, Mundis, G., additional, Hostin, R., additional, Hart, R., additional, Shaffrey, C., additional, Bess, S., additional, Ames, C., additional, Schwab, F., additional, Lafage., V., additional, Lafage, V., additional, Errico., T., additional, Soroceanu, A., additional, Smith, J.S., additional, Burton, D., additional, Errico, T., additional, Kim, H. Jo, additional, Urquhart, J., additional, Gananapathy, V., additional, Siddiqi, F., additional, Gurr, K., additional, Bailey, C., additional, Ravi, B., additional, David, K., additional, Rampersaud., R., additional, Tu, Y.S., additional, Salter., M., additional, Nichol, H., additional, Fourney, D., additional, Kelly., M., additional, Parker, R., additional, Ellis, N., additional, Blecher, C., additional, Chow, F., additional, Claydon., M., additional, Sardar, Z., additional, Alexander, D., additional, Oxner, W., additional, Plessis, S. du, additional, Yee, A., additional, Wai., E., additional, Lewis, S.J., additional, Davey, J.R., additional, Gandhi, R., additional, Mahomed., N., additional, Hu, R., additional, Thomas, K., additional, Hepler, C., additional, Choi, K., additional, Rowed, K., additional, Haig., A., additional, Lam., K., additional, Seex., K., additional, Perruccio, A.V., additional, Program., UHN Arthritis, additional, Goss, B., additional, Ballok., Z., additional, Chan, P., additional, Varma., D., additional, Swart, A., additional, Winder, M., additional, Varga, P. Pal, additional, Gokaslan, Z., additional, Boriani, S., additional, Luzzati, A., additional, Rhines, L., additional, Fisher, C., additional, Chou, D., additional, Williams, R., additional, Dekutoski, M., additional, Quraishi, N., additional, Bettegowda, C., additional, Kawahara, N., additional, Fehlings., M., additional, Versteeg, A., additional, Williams, R.P., additional, Reynolds, J., additional, Fehlings, M., additional, Rhines., L., additional, Zamorano, J., additional, Nater, A., additional, Tetrault, L., additional, Varga, P., additional, Chou., D., additional, Kopjar, B., additional, Vaccaro, A., additional, Arnold, P., additional, Schuster, J., additional, Finkelstein, J., additional, France., J., additional, Whyne, C., additional, Singh, D., additional, Ford., M., additional, Aldebeyan, W., additional, Ouellet, J., additional, Steffen, T., additional, Beckman, L., additional, Weber, M., additional, Jarzem., P., additional, Kwon, B.K., additional, Ahn, H., additional, Bailey, C.S., additional, Fehlings, M.G., additional, Fourney, D.R., additional, Gagnon, D., additional, Tsai, E.C., additional, Tsui, D., additional, Parent, S., additional, Chen, J., additional, Dvorak, M., additional, Noonan, V.K., additional, Rivers, C.S., additional, Network, RHSCIR, additional, Batke, J., additional, Lenehan, B., additional, Street., J., additional, Fox, R., additional, Nataraj, A., additional, Christie, S.D., additional, Duggal, N., additional, Hurlbert, R.J., additional, Townson, A., additional, Attabib, N., additional, Network., RHSCIR, additional, Paquet, J., additional, Johnson, M.G., additional, Shen, T., additional, Drew, B., additional, Fallah, N., additional, Davidson, S., additional, McCann, C., additional, Akens, M., additional, Murphy, K., additional, Sherar, M., additional, Yee., A., additional, Belanger, L., additional, Ronco, J., additional, Dea, N., additional, Paquette, S., additional, Boyd, M., additional, Street, J., additional, Kwon, B., additional, Gonzalvo, A., additional, Fitt, G., additional, Liew, S., additional, de la Harpe, D., additional, Turner, P., additional, Rogers, M., additional, Bidos, A., additional, Fanti, C., additional, Young, B., additional, Puskas., D., additional, Tam, H., additional, Manansala, S., additional, Nosov, V., additional, Delva, M.L., additional, Alshafai, N., additional, Tan, G., additional, Ibrahim, A., additional, Tetrault., L., additional, Sundararajan, K., additional, Eng., S., additional, St-Pierre, G.H., additional, Rosas-Arellano, P., additional, Tallon, C., additional, Gurr, K.R., additional, Bailey, S.I., additional, Rosa-Arellano, P., additional, Bailey, S., additional, Bailey., C., additional, Milili, L., additional, Malham., G., additional, Green, A.J., additional, McKeon, M., additional, Abraham., E.P., additional, Lafave, L., additional, Parnell, J., additional, Rempel, J., additional, Moriartey, S., additional, Andreas, Y., additional, Wilson, P., additional, Ray, H., additional, Hu., R., additional, Ploumis, A., additional, Hess, K., additional, Wood., K., additional, Yarascavitch, B., additional, Madden, K., additional, Ghert, M., additional, Bhandari, M., additional, Kwok, D., additional, Tu, Y.-S., additional, Hadlow., A., additional, Tso, P., additional, Walker, K., additional, Mahomed, N., additional, Coyte., P.C., additional, deGuise, J., additional, Jack, A., additional, Leroux, T., additional, Broad, R., additional, Hall, H., additional, Christie, S., additional, Carey, T., additional, Mehta, V., additional, Wadey., V., additional, Dear, T., additional, Hashem., M., additional, Goldstein, S., additional, Bodrogi, A., additional, Lipkus, M., additional, Keshen, S., additional, Veillette, C., additional, Adams, D., additional, Briggs, N., additional, Lau, J., additional, Lewis, S., additional, Magtoto, R., additional, Marshall, K.W., additional, Massicotte, E., additional, Ogilvie-Harris, D., additional, Sarro, A., additional, Syed, K., additional, Mohamed., N., additional, Perera, S., additional, Taha, A., additional, Cho, R., additional, Swamy, G., additional, Power, C.L., additional, Henari, S., additional, Lenehan., B., additional, McIntosh, G., additional, Hoffman., C., additional, Karachi, A., additional, Pazionis, T., additional, AlShaya, O., additional, Manson., N.A., additional, Murray, J., additional, Suttor, S., additional, Goyal, T., additional, Littlewood, J., additional, Bains, I., additional, Bouchard, J., additional, Jacobs, B., additional, Johnson, M., additional, Pelleck, V., additional, Amad, Y., additional, Ramos, E., additional, and Glazebrook, C., additional

Published
2014
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33. Skader oppstått på skolen hos barn mellom sju og 15 år

Author

Schuller, A A and Kopjar, B

Subjects
Male, Accident Prevention, Injury Severity Score, Schools, Adolescent, Norway, Accidents, Incidence, Athletic Injuries, Humans, Wounds and Injuries, Female, Child
Abstract

This study had two purposes: first, to describe the incidence and characteristics of school injuries among 7 to 15 year old pupils in Norway; second, to identify effective preventive measures. Data on school injuries were taken from the Norwegian National Injury Register (National Institute of Public Health) for the 1995-97 period, n = 2,975. The incidence of school injuries was 29 per 1,000 children-years. Over the nine-year age span, boys had a higher cumulative incidence (292 injuries per 1,000 boys) than girls (239 injuries per 1,000 girls); 1% of the injuries was categorized as severe. Among pupils aged 7-12, 34% of injuries occurred during sports activities; among the 13-15 age group, 60% were related to sports. A literature review was conducted in order to identify preventive measures shown to be effective in reducing school injuries. The databases used were Cochrane Library (issue 4, 1998), Medline (1966-98) and Embase (1980-98). However, no studies found in the literature had evaluated preventive measures. On the basis of our findings, we suggest that preventive measures should emphasise non-sport injuries among the younger pupils and sport injuries among the older pupils. Preventive measures should be evaluated.

Published
2000

34. Canadian Spine Society abstracts1.1.01 Supraspinal modulation of gait abnormalities associated with noncompressive radiculopathy may be mediated by altered neurotransmitter sensitivity1.1.02 Neuroprotective effects of the sodium-glutamate blocker riluzole in the setting of experimental chronic spondylotic myelopathy1.1.03 The effect of timing to decompression in cauda equina syndrome using a rat model1.2.04 Intraoperative waste in spine surgery: incidence, cost and effectiveness of an educational program1.2.05 Looking beyond the clinical box: the health services impact of surgical adverse events1.2.06 Brace versus no brace for the treatment of thoracolumbar burst fractures without neurologic injury: a multicentre prospective randomized controlled trial1.2.07 Adverse event rates in surgically treated spine injuries without neurologic deficit1.2.08 Functional and quality of life outcomes in geriatric patients with type II odontoid fracture: 1-year results from the AOSpine North America Multi-Center Prospective GOF Study1.3.09 National US practices in pediatric spinal fusion: in-hospital complications, length of stay, mortality, costs and BMP utilization1.3.10 Current trends in the surgical treatment of adolescent idiopathic scoliosis in Canada1.3.11 Sagittal spinopelvic parameters help predict the risk of proximal junctional kyphosis for children treated with posterior distraction-based implants1.4.12 Correlations between changes in surface topography and changes in radiograph measurements from before to 6 months after surgery in adolescents with idiopathic scoliosis1.4.13 High upper instrumented vertebra (UIV) sagittal angle is associated with UIV fracture in adult deformity corrections1.4.14 Correction of adult idiopathic scoliosis using intraoperative skeletal traction1.5.01 Cauda equina: using management protocols to reduce delays in diagnosis1.5.02 Predicting the need for tracheostomy in patients with acute traumatic spinal cord injury1.5.03 A novel animal model of cervical spondylotic myelopathy: an opportunity to identify new therapeutic targets1.5.04 A review of preference-based measures of health-related quality of life in spinal cord injury research1.5.05 Predicting postoperative neuropathic pain following surgery involving nerve root manipulation based on intraoperative electromyographic activity1.5.06 Detecting positional injuries in prone spinal surgery1.5.07 Percutaneous thoracolumbar stabilization for trauma: surgical morbidity, clinical outcomes and revision surgery1.5.08 Systemic inflammatory response syndrome in spinal cord injury patients: Does its presence at admission affect patient outcomes?2.1.15 One hundred years of spine surgery — a review of the evolution of our craft and practice in the spine surgical century [presentation]2.1.16 Prevalence of preoperative MRI findings of adjacent segment disc degeneration in patients undergoing anterior cervical discectomy and fusion2.1.17 Adverse event rates of surgically treated cervical spondylopathic myelopathy2.1.18 Morphometricand dynamic changes in the cervical spine following anterior cervical discectomy and fusion and cervical disc arthroplasty2.1.19 Is surgery for cervical spondylotic myelopathy cost-effective? A cost–utility analysis based on data from the AO Spine North American Prospective Multicentre CSM Study2.2.20 Cost–utility of lumbar decompression with or without fusion for patients with symptomatic degenerative lumbar spondylolisthesis (DLS)2.2.21 Minimally invasive surgery lumbar fusion for low-grade isthmic and degenerative spondylolisthesis: 2- to 5-year follow-up2.2.22 Results and complications of posterior-only reduction and fusion for high-grade spondylolisthesis2.3.23 Fusion versus no fusion in patients with central lumbar spinal stenosis and foraminal stenosis undergoing decompression surgery: comparison of outcomes at baseline and follow-up2.3.24 Two-year results of interspinous spacers (DIAM) as an alternative to arthrodesis for lumbar degenerative disorders2.3.25 Treatment of herniated lumbar disc by sequestrectomy or conventional discectomy2.4.26 No sustained benefit of continuous epidural analgesia for minimally invasive lumbar fusion: a randomized double-blinded placebo controlled study2.4.27 Evidence and current practice in the radiologic assessment of lumbar spine fusion2.4.28 Wiltse versus midline approach for decompression and fusion of the lumbar spine2.5.09 The effect of soft tissue restraints following type II odontoid fractures in the elderly — a biomechanical study2.5.10 Development of an international spinal cord injury (SCI) spinal column injury basic data set2.5.11 Evaluation of instrumentation techniques for a unilateral facet perch and fracture using a validated soft tissue injury model2.5.12 Decreasing neurologic consequences in patients with spinal infection: the testing of a novel diagnostic guideline2.5.13 Prospective analysis of adverse events in surgical treatment of degenerative spondylolisthesis2.5.14 Load transfer characteristics between posterior fusion devices and the lumbar spine under anterior shear loading: an in vitro investigation2.5.15 Preoperative predictive clinical and radiographic factors influencing functional outcome after lumbar discectomy2.5.16 A Thoracolumbar Injury Classification and Severity Score (TLICS) of 4: What should we really do?3.1.29 Adverse events in emergent oncologic spine surgery: a prospective analysis3.1.30 En-bloc resection of primary spinal and paraspinal tumours with critical vascular involvement3.1.31 The treatment impact of minocycline on quantitative MRI in acute spinal cord injury3.1.32 Benefit of minocycline in spinal cord injury — results of a double-blind randomized placebo-controlled study3.2.33 Improvement of magnetic resonance imaging correlation with unilateral motor or sensory deficits using diffusion tensor imaging3.2.34 Comparing care delivery for acute traumatic spinal cord injury in 2 Canadian centres: How do the processes of care differ?3.2.35 Improving access to early surgery: a comparison of 2 centres3.3.36 The effects of early surgical decompression on motor recovery after traumatic spinal cord injury: results of a Canadian multicentre study3.3.37 A clinical prediction model for long-term functional outcome after traumatic spinal cord injury based on acute clinical and imaging factors3.3.38 Effect of motor score on adverse events and quality of life in patients with traumatic spinal cord injury3.4.39 The impact of facet dislocation on neurologic recovery after cervical spinal cord injury: an analysis of data on 325 patients from the Surgical Trial in Acute Spinal Cord Injury Study (STASCIS)3.4.40 Toward a more precise understanding of the epidemiology of traumatic spinal cord injury in Canada3.4.41 Access to care (ACT) for traumatic SCI: a survey of acute Canadian spine centres3.4.42 Use of the Spine Adverse Events Severity (SAVES) instrument for traumatic spinal cord injury3.5.17 Does the type of distraction-based growing system for early onset scoliosis affect postoperative sagittal alignment?3.5.18 Comparison of radiation exposure during thoracolumbar fusion using fluoroscopic guidance versus anatomic placement of pedicle screws3.5.19 Skeletal traction for intraoperative reduction in adolescent idiopathic scoliosis3.5.20 Utility of intraoperative cone-beam computed tomography (O-ARM) and stereotactic navigation in acute spinal trauma surgery3.5.21 Use of a central compression rod to reduce thoracic level spinal osteotomies3.5.22 ICD-10 coding accuracy for spinal cord injured patients3.5.23 Feasibility of patient recruitment in acute SCI trials3.5.24 Treatment of adult degenerative scoliosis with DLIF approaches

Author

Shamji, M., primary, Moon, E. Su, primary, Glennie, R.A., primary, Soroceanu, A., primary, Lin, C., primary, Bailey, C.S., primary, Simmonds, A., primary, Fehlings, M., primary, Dodwell, E., primary, Dold, A., primary, El-Hawary, R., primary, Hashem, M., primary, Jones, S., primary, Karadimas, S., primary, Whitehurst, D., primary, Norton, J., primary, Manson, N.A, primary, Kesani, A., primary, Bednar, Drew, primary, Lundine, K., primary, Hartig, D., primary, Fichadi, A., primary, Kim, S., primary, Harris, S.A., primary, Gill, J., primary, Abraham, E., primary, Choi, S., primary, Goldstein, C., primary, Wang, Z., primary, McCabe, M., primary, Noonan, V.K., primary, Nadeau, M., primary, Ferrara, S., primary, Kelly, A., primary, Melnyk, A., primary, Arora, D., primary, Quateen, A., primary, Dea, N., primary, Ranganathan, A., primary, Zhang, Y., primary, Casha, S., primary, Rajamanickam, K., primary, Santos, A., primary, Wilson, J., primary, Street, J., primary, Lewis, R., primary, Egge, N., primary, Schouten, R., primary, Kim, A., primary, Kwon, B., primary, Huang, E., primary, Hwang, P., additional, Allen, K., additional, Jing, L., additional, Mata, B., additional, Gabr, M., additional, Richardson, W., additional, Setton, L., additional, Karadimas, S., additional, Fehlings, M., additional, Fleming, J., additional, Bailey, C.S., additional, Gurr, K., additional, Bailey, S., additional, Siddiqi, F., additional, Lawendy, A., additional, Sanders, D., additional, Staudt, M., additional, Canacari, E., additional, Brown, E., additional, Robinson, A., additional, McGuire, K., additional, Chrysostoum, C., additional, Rampersaud, Y. Raja, additional, Dvorak, M.F., additional, Thomas, K.C., additional, Boyd, M.C., additional, Gurr, K.R., additional, Bailey, S.I., additional, Nadeau, M., additional, Fisher, C.G, additional, Batke, J., additional, Street, J., additional, Boyd, M., additional, Dvorak, M., additional, Fisher, C., additional, Kwon, B., additional, Paquette, S., additional, Vaccaro, A., additional, Chapman, J., additional, Arnold, P., additional, Shaffrey, C., additional, Kopjar, B., additional, Snyder, B., additional, Wright, J., additional, Lewis, S., additional, Zeller, R., additional, El-Hawary, R., additional, Moroz, P., additional, Bacon, S., additional, Jarzem, P., additional, Hedden, D., additional, Howard, J., additional, Sturm, P., additional, Cahill, P., additional, Samdani, A., additional, Vitale, M., additional, Gabos, P., additional, Bodin, N., additional, d’Amato, C., additional, Harris, C., additional, Smith, J., additional, Parent, E., additional, Hill, D., additional, Moreau, M., additional, Mahood, J., additional, Bodrogi, A., additional, Abbas, H., additional, Goldstein, S., additional, Bronstein, Y., additional, Chua, S., additional, Magana, S., additional, Van Houwelingen, A., additional, Halpern, E., additional, Jhaveri, S., additional, Lim, A., additional, Leelapattana, P., additional, Siddiqqi, F., additional, Moon, E. Su, additional, Satkunendrarajah, K., additional, Noonan, V., additional, Bryan, S., additional, Aronyk, K., additional, Fox, R., additional, Nataraj, A., additional, Pugh, J., additional, Elliott, R., additional, McKeon, M., additional, Abraham, E.P., additional, Davis, G., additional, Rogers, M., additional, Staples, M., additional, Quan, G., additional, Shamji, M., additional, Hurlbert, R.J., additional, Jacobs, W.B., additional, Duplessis, S., additional, Casha, S., additional, Jha, N., additional, Hewson, S., additional, Massicotte, E., additional, Mortaz, S., additional, Coyte, P., additional, Rampersaud, Y.R., additional, Andrew, B., additional, Modi, H., additional, Roffey, D., additional, Miles, I., additional, Wai, E., additional, Manson, N., additional, Eastwood, D., additional, Elliot, R., additional, Bains, I., additional, Yong, E., additional, Sutherland, G., additional, Chan, V.W.S., additional, Persaud, O., additional, Koshkin, A., additional, Brull, R., additional, Hassan, N., additional, Petis, S., additional, Kowalczuk, M., additional, Petrisor, B., additional, Drew, B., additional, Bhandari, M., additional, DiPaola, C., additional, McLachlin, S., additional, Bailey, C., additional, Dunning, C., additional, Fehlings, M.G., additional, Wing, P., additional, Itshayek, E., additional, Biering-Sorensen, F., additional, Bradi, A., additional, Pokrupa, R., additional, Kelly, A., additional, Wen, T., additional, Kingwell, S., additional, Chak, J., additional, Singh, V., additional, Cripton, P., additional, Oxland, T., additional, Wali, Z., additional, Yen, D., additional, Alfllouse, A., additional, Alzahrani, A., additional, Jiang, H., additional, Kortbeek, F., additional, Reddy, R., additional, Rampersaud, R., additional, Hurlbert, J., additional, Yong, W., additional, Zygun, D., additional, McGowan, D., additional, Yong, V.W., additional, Mendis, B., additional, Chakraborty, S., additional, Nguyen, T., additional, Tsai, E., additional, Chen, A., additional, Atkins, D., additional, Noonan, V.K., additional, Tsui, D., additional, Townson, A., additional, Craven, C., additional, Ford, M., additional, Ahn, H., additional, Kiss, A., additional, Harrop, J., additional, Grossman, R., additional, Frankowski, R., additional, Guest, J., additional, Aarabi, B., additional, Cheung, A., additional, Sun, B., additional, Marais, L., additional, Queyranne, M., additional, Fourney, D., additional, Johnson, M., additional, Yee, A., additional, Finkelstein, J., additional, Paquet, J., additional, Parent, S., additional, Christie, S., additional, Lange, J., additional, Lapinsky, A., additional, Connolly, P., additional, Eck, J., additional, Rabin, D., additional, Lee, R., additional, Sofia, M., additional, Shin, J., additional, Tung, K., additional, Ghag, R., additional, Goyal, T., additional, Littlewood, J., additional, Cho, R., additional, Thomas, K., additional, and Swamy, G., additional

Published
2012
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38. Occurrence and trends in ski injuries in Norway.

Author

Ueland O, Kopjar B, Ueland, O, and Kopjar, B

Abstract

Objectives: To provide an overview of ski injuries in Norway and to describe the changes between 1990 and 1996.Methods: All ski injuries (7966) treated at four hospitals providing health care to a defined population of about 11% of the Norwegian population were registered prospectively from 1990 to 1996. For this study, 6462 injuries sustained in cross country skiing, downhill skiing, telemark skiing, and snowboarding were selected for further analysis.Results: The relative distribution of ski injuries by type of skiing changed significantly from 1990 to 1996 (p<0.001). Injuries from snowboarding showed the highest relative increase, and those sustained during downhill skiing showed a decline. The proportion of fractures in all types of skiing increased during the study period (p=0.001). The proportion of injuries to knee/lower leg decreased and the proportion to the forearm/wrist/hand increased during the study period (p=0.03). The mean age of the injured skiers differed significantly among the different types of skiing activity (p<0.001): cross country skiers were the oldest followed by telemark skiers, downhill skiers, and snowboarders.Conclusions: Ski injury surveillance results in early detection of changes in temporal injury trends, allowing timely adjustment of injury prevention strategies. Injuries from snowboarding are on the increase in Norway, warranting more effective injury prevention measures. [ABSTRACT FROM AUTHOR]

Published
1998

40. Rationale, design and critical end points for the Riluzole in Acute Spinal Cord Injury Study (RISCIS): a randomized, double-blinded, placebo-controlled parallel multi-center trial

Author

Fehlings, M G, Nakashima, H, Nagoshi, N, Chow, D S L, Grossman, R G, and Kopjar, B

Abstract

Background:Riluzole is a sodium channel-blocking agent used in treating amyotrophic lateral sclerosis. It has been approved by the U.S. Food and Drug Administration, Canadian and Australian authorities, and in many other countries. A phase I trial of riluzole for acute spinal cord injury (SCI) provided safety and pharmacokinetic data and suggested neuroprotective benefits. A phase IIB/III double-blinded randomized controlled trial (RCT) started in January 2014 (https://clinicaltrials.gov, NCT01597518). This article describes the pathophysiological rationale, preclinical experience and design of the phase IIB/III RCT of Riluzole in Acute Spinal Cord Injury Study (RISCIS).Objectives:The primary objective of the trial is to evaluate the superiority of riluzole, at a dose of 100 mg BID in the first 24 h followed by 50 mg BID for the following 13 days post injury, compared with placebo in improving neurological motor outcomes in patients with C4–C8 level, International Standards for Neurological Classification of Spinal Cord Injury Examination (ISNCSCI) grade A, B or C acute (within 12 h post injury) SCI.Setting:Acute trauma centers worldwideMethods:A double-blind, multi-center, placebo-controlled RCT will enroll 351 participants randomized 1:1 to riluzole and placebo. The primary end point is the change between 180 days and baseline in ISNCSCI Motor Score. This study has 90% power to detect a change of nine points in ISNCSCI Motor Score at one-sided α=0.025.Results:Currently enrolling in 11 centers.Conclusion:This study will provide class I evidence regarding the safety and neuroprotective efficacy of riluzole in patients with acute cervical SCI.

Published
2016
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