1. Population-Based Geospatial and Molecular Epidemiologic Study of Tuberculosis Transmission Dynamics, Botswana, 2012-2016.
- Author
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Zetola, Nicola M., Moonan, Patrick K., Click, Eleanor, Oeltmann, John E., Basotli, Joyce, Xiao-Jun Wen, Boyd, Rosanna, Tobias, James L., Finlay, Alyssa, Modongo, Chawangwa, and Wen, Xiao-Jun
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MYCOBACTERIUM tuberculosis , *TUBERCULOSIS , *TANDEM repeats , *RESPIRATORY infections - Abstract
Tuberculosis (TB) elimination requires interrupting transmission of Mycobacterium tuberculosis. We used a multidisciplinary approach to describe TB transmission in 2 sociodemographically distinct districts in Botswana (Kopanyo Study). During August 2012-March 2016, all patients who had TB were enrolled, their sputum samples were cultured, and M. tuberculosis isolates were genotyped by using 24-locus mycobacterial interspersed repetitive units-variable number of tandem repeats. Of 5,515 TB patients, 4,331 (79%) were enrolled. Annualized TB incidence varied by geography (range 66-1,140 TB patients/100,000 persons). A total of 1,796 patient isolates had valid genotyping results and residential geocoordinates; 780 (41%) patients were involved in a localized TB transmission event. Residence in areas with a high burden of TB, age <24 years, being a current smoker, and unemployment were factors associated with localized transmission events. Patients with known HIV-positive status had lower odds of being involved in localized transmission. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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