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6. The Effect of Creatine Nitrate and Caffeine Individually or Combined on Exercise Performance and Cognitive Function: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial.

Author

Mabrey, Gina, Koozehchian, Majid S., Newton, Andrew T., Naderi, Alireza, Forbes, Scott C., and Haddad, Monoem

Abstract

This study examined the effect of creatine nitrate and caffeine alone and combined on exercise performance and cognitive function in resistance-trained athletes. In a double-blind, randomized crossover trial, twelve resistance-trained male athletes were supplemented with 7 days of creatine nitrate (5 g/day), caffeine (400 mg/day), and a combination of creatine nitrate and caffeine. The study involved twelve resistance-trained male athletes who initially provided a blood sample for comprehensive safety analysis, including tests for key enzymes and a lipid profile, and then performed standardized resistance exercises—bench and leg press at 70% 1RM—and a Wingate anaerobic power test. Cognitive function and cardiovascular responses were also examined forty-five minutes after supplementation. Creatine nitrate and caffeine that were co-ingested significantly enhanced cognitive function, as indicated by improved scores in the Stroop Word–Color Interference test (p = 0.04; effect size = 0.163). Co-ingestion was more effective than caffeine alone in enhancing cognitive performance. In contrast, no significant enhancements in exercise performance were observed. The co-ingestion of creatine nitrate and caffeine improved cognitive function, particularly in cognitive interference tasks, without altering short-term exercise performance. Furthermore, no adverse events were reported. Overall, the co-ingestion of creatine nitrate and caffeine appears to enhance cognition without any reported side effects for up to seven days. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Caffeinated Chewing Gum Improves Bicycle Motocross Time-Trial Performance.

Author

Daneshfar, Amin, Petersen, Carl J., Koozehchian, Majid S., and Gahreman, Daniel E.

Subjects
ATHLETIC ability, CAFFEINE, CENTRAL nervous system, CHEWING gum, CROSSOVER trials, CYCLING, EXPERIMENTAL design, INGESTION, RANDOMIZED controlled trials, BLIND experiment, DATA analysis software, DESCRIPTIVE statistics, PHARMACODYNAMICS
Abstract

This study aimed to identify the acute effects of caffeinated chewing gum (CAF) on bicycle motocross (BMX) time-trial (TT) performance. In a randomized, placebo-controlled, double-blind cross-over design, 14 male BMX riders (age = 20.0 ± 3.3 years; height = 1.78 ± 0.04 m; body mass = 72 ± 4 kg), consumed either (300 mg; 4.2 ± 0.2 mg/kg) caffeinated (300 mg caffeine, 6 g sugars) or a placebo (0 mg caffeine, 0 g sugars) gum, and undertook three BMX TTs. Repeated-measure analysis revealed that CAF has a large ergogenic effect on TT time, F(1, 14) = 33.570, p =.001, η p 2 =.71 ; −1.5% ± 0.4 compared with the placebo. Peak power and maximal power to weight ratio also increased significantly compared with the placebo condition, F(1, 14) = 54.666, p =.001, η p 2 =.79 ; +3.5% ± 0.6, and F(1, 14) = 57.399, p =.001, η p 2 =.80 ; +3% ± 0.3, respectively. Rating of perceived exertion was significantly lower F(1, 14) = 25.020, p =.001, η p 2 =.64 in CAF (6.6 ± 1.3) compared with the placebo (7.2 ± 1.7). Administering a moderate dose (300 mg) of CAF could improve TT time by enhancing power and reducing the perception of exertion. BMX coaches and riders may consider consuming CAF before a BMX race to improve performance and reduce rating of perceived exertion. [ABSTRACT FROM AUTHOR]

Published
2020
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14. Comparison of Two Diet and Exercise Approaches on Weight Loss and Health Outcomes in Obese Women

Author

Lockard, Brittanie, primary, Mardock, Michelle, additional, Oliver, Jonathan M., additional, Byrd, Mike, additional, Simbo, Sunday, additional, Jagim, Andrew R., additional, Kresta, Julie, additional, Baetge, Claire C., additional, Jung, Yanghoon Peter, additional, Koozehchian, Majid S., additional, Khanna, Deepesh, additional, Rasmussen, Chris, additional, and Kreider, Richard B., additional

Published
2022
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16. Effects of Beetroot Juice Supplementation on Cognitive Function, Aerobic and Anaerobic Performances of Trained Male Taekwondo Athletes: A Pilot Study

Author

Miraftabi, Hossein, primary, Avazpoor, Zahra, additional, Berjisian, Erfan, additional, Sarshin, Amir, additional, Rezaei, Sajjad, additional, Domínguez, Raúl, additional, Reale, Reid, additional, Franchini, Emerson, additional, Samanipour, Mohammad Hossein, additional, Koozehchian, Majid S., additional, Willems, Mark E. T., additional, Rafiei, Ramin, additional, and Naderi, Alireza, additional

Published
2021
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17. Acute doses of beetroot juice supplementation on aerobic and anaerobic performance of trained male taekwondo athletes v1

Author

Miraftabi, Hossein, primary, Avazpoor, Zahra, additional, Berjisian, Erfan, additional, Sarshin, Amir, additional, Rezaei, Sajjad, additional, Domínguez, Raúl, additional, Reale, Reid, additional, Franchini, Emerson, additional, Hossein Samanipour, Mohammad, additional, S. Koozehchian, Majid, additional, E.T. Willems, Mark, additional, Rafiei, Ramin, additional, and Naderi, Alireza, additional

Published
2021
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18. Effects of Beetroot Juice Supplementation on Cognitive Function, Aerobic and Anaerobic Performances of Trained Male Taekwondo Athletes: A Pilot Study

Author

Universidad de Sevilla. Departamento de Motricidad Humana y Rendimiento Deportivo, Miraftabi, Hossein, Avazpoor, Zahra, Berjisian, Erfan, Sarshin, Amir, Rezaei, Sajjad, Domínguez Herrera, Raúl, Reid, Reale, Franchini, Emerson, Samanipour, Mohammad Hossein, Koozehchian, Majid S., Willems, Mark E.T., Rafiei, Ramin, Naderi, Alireza, Universidad de Sevilla. Departamento de Motricidad Humana y Rendimiento Deportivo, Miraftabi, Hossein, Avazpoor, Zahra, Berjisian, Erfan, Sarshin, Amir, Rezaei, Sajjad, Domínguez Herrera, Raúl, Reid, Reale, Franchini, Emerson, Samanipour, Mohammad Hossein, Koozehchian, Majid S., Willems, Mark E.T., Rafiei, Ramin, and Naderi, Alireza

Abstract

Studies have shown that nitrate (NO3 −)-rich beetroot juice (BJ) supplementation improves endurance and high-intensity intermittent exercise. The dose–response effects on taekwondo following BJ supplementation are yet to be determined. This study aimed to investigate two acute doses of 400 mg of NO3 − (BJ-400) and 800 mg of NO3 − (BJ-800) on taekwondo-specific performance and cognitive function tests compared with a placebo (PL) and control (CON) conditions. Eight trained male taekwondo athletes (age: 20 ± 4 years, height: 180 ± 2 cm, body mass: 64.8 ± 4.0 kg) completed four experimental trials using a randomized, double-blind placebo-controlled design: BJ-400, BJ-800, PL, and CON. Participants consumed two doses of BJ-400 and BJ-800 or nitrate-depleted PL at 2.5 h prior to performing the Multiple Frequency Speed of Kick Test (FSKT). Countermovement jump (CMJ) was performed before the (FSKT) and PSTT, whereas cognitive function was assessed (via the Stroop test) before and after supplementation and 10 min following PSTT. Blood lactate was collected before the CMJ tests immediately and 3 min after the FSKT and PSST; rating of perceived exertion (RPE) was recorded during and after both specific taekwondo tests. No significant differences (p > 0.05), with moderate and large effect sizes, between conditions were observed for PSTT and FSKT performances. In addition, blood lactate, RPE, heart rate, and CMJ height were not significantly different among conditions (p > 0.05). However, after the PSTT test, cognitive function was higher in BJ-400 compared to other treatments (p < 0.05). It was concluded that acute intake of 400 and 800 mg of NO3 − rich BJ reported a moderate to large effect size in anaerobic and aerobic; however, no statistical differences were found in taekwondo-specific performance.

Published
2021

20. The acute caffeine ingestion improved performance during traditional and cluster‐based resistance training models in resistance‐trained male athletes

Author

Koozehchian, Majid, primary, Sarshin, Amir, additional, Hatami Nasab, Zahra, additional, Naderi, Alireza, additional, Rahimi, Alireza, additional, Feizolahi, Foad, additional, Karayigit, Raci, additional, Berjisian, Erfan, additional, Forbes, Scott, additional, and Candow, Darren, additional

Published
2021
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27. Effects of high carbohydrate or high protein energy-restricted diets combined with resistance-exercise on weight loss and markers of health in women with serum triglyceride levels above or below median values

Author

Oliver Jonathan M, Kresta Julie Y, Byrd Mike, Canon Claire, Mardock Michelle, Simbo Sunday, Jung Peter, Lockard Brittanie, Khanna Deepesh, Koozehchian Majid, Rasmussen Chris, Kerksick Chad, and Kreider Richard

Subjects
Nutrition. Foods and food supply, TX341-641, Sports medicine, RC1200-1245
Published
2010
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33. Effects of Energy and Macronutrient Cycling on Weight Loss, Body Composition, and Markers of Health in Obese Women Participating in a Resistance-Based Exercise Program

Author

Kresta, Julie, primary, Byrd, Mike, additional, Oliver, Jonathan, additional, Baetge, Claire, additional, Mardock, Michelle, additional, Simbo, Sunday, additional, Jung, Y, additional, Koozehchian, Majid, additional, Khanna, Deepesh, additional, Lockard, Brittanie, additional, Dalton, Ryan, additional, Rasmussen, Christopher, additional, and Kreider, Richard, additional

Published
2020
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35. Multi Directional Repeated Sprint Is a Valid and Reliable Test for Assessment of Junior Handball Players

Author

Daneshfar, Amin, Gahreman, Daniel E, Koozehchian, Majid S, Amani Shalamzari, Sadegh, Hassanzadeh Sablouei, Mozhgan, Rosemann, Thomas; https://orcid.org/0000-0002-6436-6306, Knechtle, Beat; https://orcid.org/0000-0002-2412-9103, Nikolaidis, Pantelis T, Daneshfar, Amin, Gahreman, Daniel E, Koozehchian, Majid S, Amani Shalamzari, Sadegh, Hassanzadeh Sablouei, Mozhgan, Rosemann, Thomas; https://orcid.org/0000-0002-6436-6306, Knechtle, Beat; https://orcid.org/0000-0002-2412-9103, and Nikolaidis, Pantelis T

Abstract

The aim of the present study was to examine the validity and reliability of a 10 × (6 × 5 m) multi-directional repeated sprint ability test (RSM) in elite young team handball (TH) players. Participants were members of the Iranian national team ( = 20, age 16.4 ± 0.7 years, weight 82.5 ± 5.5 kg, height 184.8 ± 4.6 cm, body fat 15.4 ± 4.3%). The validity of RSM was tested against a 10 × (15 + 15 m) repeated sprint ability test (RSA), Yo-Yo Intermittent Recovery test Level 1 (Yo-Yo IR1), squat jump (SJ) and countermovement jump (CMJ). To test the reliability of RSM, the participants repeated the testing sessions of RSM and RSA 1 week later. Both RSA and RSM tests showed good to excellent reliability of the total time (TT), best time (BT), and weakest time (WT). The results of the correlation analysis showed significant inverse correlations between maximum aerobic capacity and TT in RSA ( = -0.57, ≤ 0.05) and RSM ( = -0.76, ≤ 0.01). There was also a significant inverse correlation between maximum aerobic capacity with fatigue index (FI) in RSA test ( = -0.64, ≤ 0.01) and in RSM test ( = -0.53, ≤ 0.05). BT, WT, and TT of RSA was largely-to-very largely correlated with BT ( = 0.58, ≤ 0.01), WT ( = 0.62, ≤ 0.01), and TT ( = .65, ≤ 0.01) of RSM. BT in RSM was also correlated with FI in RSM ( = 0.88, ≤ 0.01). In conclusion, based on the findings of the current study, the recently developed RSM test is a valid and reliable test and should be utilized for assessment of repeated sprint ability in handball players.

Published
2018

38. Effects of nine weeks L-Carnitine supplementation on exercise performance, anaerobic power, and exercise-induced oxidative stress in resistance-trained males

Author

Koozehchian, Majid S., primary, Daneshfar, Amin, additional, Fallah, Ebrahim, additional, Agha-Alinejad, Hamid, additional, Samadi, Mohammad, additional, Kaviani, Mojtaba, additional, Kaveh B, Maryam, additional, Jung, Y. Peter, additional, Sablouei, Mozhgan Hassanzadeh, additional, Moradi, Najmeh, additional, Earnest, Conrad P., additional, Chandler, T. Jeff, additional, and Kreider, Richard B., additional

Published
2018
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41. Hematological and Hemodynamic Responses to Acute and Short-Term Creatine Nitrate Supplementation

Author

Dalton, Ryan, primary, Sowinski, Ryan, additional, Grubic, Tyler, additional, Collins, Patrick, additional, Coletta, Adriana, additional, Reyes, Aimee, additional, Sanchez, Brittany, additional, Koozehchian, Majid, additional, Jung, Yanghoon, additional, Rasmussen, Christopher, additional, Greenwood, Mike, additional, Murano, Peter, additional, Earnest, Conrad, additional, and Kreider, Richard, additional

Published
2017
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42. Dose Response to One Week of Supplementation of a Multi-Ingredient Preworkout Supplement Containing Caffeine Before Exercise

Author

Koozehchian, Majid S., primary, Earnest, Conrad P., additional, Jung, Y. Peter, additional, Collins, P. Blaise, additional, O'Connor, Abigail, additional, Dalton, Ryan, additional, Shin, Song Yi, additional, Sowinski, Ryan, additional, Rasmussen, Chris, additional, Murano, Peter S., additional, Greenwood, Mike, additional, and Kreider, Richard B., additional

Published
2017
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43. Efficacy of a randomized trial examining commercial weight loss programs and exercise on metabolic syndrome in overweight and obese women

Author

Baetge, Claire, primary, Earnest, Conrad P., additional, Lockard, Brittanie, additional, Coletta, Adriana M., additional, Galvan, Elfego, additional, Rasmussen, Christopher, additional, Levers, Kyle, additional, Simbo, Sunday Y., additional, Jung, Y. Peter, additional, Koozehchian, Majid, additional, Oliver, Jonathan, additional, Dalton, Ryan, additional, Sanchez, Brittany, additional, Byrd, Michael J., additional, Khanna, Deepesh, additional, Jagim, Andrew, additional, Kresta, Julie, additional, Greenwood, Mike, additional, and Kreider, Richard B., additional

Published
2017
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44. Effects of ingesting a pre-workout dietary supplement with and without synephrine for 8 weeks on training adaptations in resistance-trained males

Author

Jung, Y. Peter, primary, Earnest, Conrad P., additional, Koozehchian, Majid, additional, Cho, Minye, additional, Barringer, Nick, additional, Walker, Dillon, additional, Rasmussen, Christopher, additional, Greenwood, Mike, additional, Murano, Peter S., additional, and Kreider, Richard B., additional

Published
2017
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45. Effects of acute ingestion of a pre-workout dietary supplement with and without p-synephrine on resting energy expenditure, cognitive function and exercise performance

Author

Jung, Y. Peter, primary, Earnest, Conrad P., additional, Koozehchian, Majid, additional, Galvan, Elfego, additional, Dalton, Ryan, additional, Walker, Dillon, additional, Rasmussen, Christopher, additional, Murano, Peter S., additional, Greenwood, Mike, additional, and Kreider, Richard B., additional

Published
2017
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46. Efficacy of Commercial Weight Loss Programs on Metabolic Syndrome

Author

Coletta, Adriana, primary, Baetge, Claire, additional, Murano, Peter, additional, Galvin, Elfego, additional, Rasmussen, Christopher, additional, Greenwood, Mike, additional, Levers, Kyle, additional, Lockard, Brittanie, additional, Simbo, Sunday Y, additional, Jung, Y Peter, additional, Koozehchian, Majid, additional, Cho, Minye, additional, Mardock, Michelle, additional, Kresta, Julie, additional, Oliver, Jonathan, additional, Sanchez, Brittany, additional, Byrd, Mike, additional, Khanna, Deepesh, additional, Jagim, Andrew, additional, Earnest, Conrad P, additional, and Kreider, Richard B, additional

Published
2016
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48. Effects of acute ingestion of a pre-workout dietary surpplement with and without p-synephrine on resting energy expenditure, cognitive function and exercise performance.

Author

Peter Jung, Y., Earnest, Conrad P., Koozehchian, Majid, Galvan, Elfego, Dalton, Ryan, Walker, Dillon, Rasmussen, Christopher, Murano, Peter S., Greenwood, Mike, and Kreider, Richard B.

Subjects
INGESTION disorders, REGULATION of ingestion, DIETARY supplements, EXERCISE, COGNITIVE ability, CREATINE kinase, KETOGLUTARATE dehydrogenase
Abstract

Background: The purpose of this study was to examine the effects of acute ingestion of a pre-workout dietary supplement (PWS) with and without p-synephrine (S) on perceptions of readiness to perform, cognitive function, exercise performance, and markers of safety. Methods: In a randomized, double-blind, and counterbalanced manner; 25 healthy and recreationally active male and female participants ingested a flavored maltodextrin placebo (PLA), a PWS containing beta-alanine (3 g), creatine nitrate as a salt (2 g), arginine alpha-ketoglutarate (2 g), N-Acetyl-L-Tyrosine (300 mg), caffeine (284 mg), Mucuna pruiriens extract standardized for 15% L-Dopa (15 mg), Vitamin C as Ascorbic Acid (500 mg), niacin (60 mg), folate as folic acid (50 mg), and Vitamin B12 as Methylcobalamin (70 mg) with 2 g of maltodextrin and flavoring; or, the PWS with Citrus aurantium (PWS + S) extract standardized for 30% p-synephrine (20 mg). Participants had heart rate (HR), blood pressure, resting energy expenditure (REE), 12-lead electrocardiograms (ECG), perceptions about readiness to perform, cognitive function (Stroop Color-Word test), bench and leg press performance (2 sets of 10 repetitions at 70% of 1RM and 1 set to failure), and Wingate anaerobic capacity (WAC) sprint performance determined as well as donated blood samples prior to and/or following exercise/supplementation. Data were analyzed by MANOVA with repeated measures as well as mean changes from baseline with 95% confidence intervals (CI). Results: No clinically significant differences were observed among treatments in HR, blood pressure, ECG, or general clinical blood panels. There was evidence that PWS and PWS + S ingestion promoted greater changes in REE responses. Participants reported higher perception of optimism about performance and vigor and energy with PWS and PWS + S ingestion and there was evidence that PWS and PWS + S improved changes in cognitive function scores from baseline to a greater degree than PLA after 1 or 2 h. However, the scores in the PWS + S treatment did not exceed PLA or PWS responses at any data point. No statistically significant differences were observed among treatments in total bench press lifting volume, leg press lifting volume or WAC sprint performance. Conclusions: Within the confines of this study, ingestion of PWS and/or PWS + S prior to exercise appears to be well-tolerated when consumed by young, healthy individuals. The primary effects appear to be to increase REE responses and improve perceptions about readiness to perform and cognitive function with limited to no effects on muscular endurance and WAC. The addition of 20 mg of p-synephrine to the PWS provided limited to no additive benefits. Trial registration: This trial (NCT02952014) was retrospectively registered on September 13th 2016. [ABSTRACT FROM AUTHOR]

Published
2017
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